Medicine / Healthcare: general issues / topics Books

Book SynopsisBehçet's Disease (BD) is one of the most-studied systemic disorders characterized by an occlusive vasculopathy of multiple organs. The etiology and pathogenesis of BD are still unclear, but there is evidence for genetic, immunologic and infectious factors in the onset and throughout the course of the disease. Immunology of Behçet's Disease highlights various aspects of BD. After an epidemiological overview, the clinical presentation of ocular and non-ocular symptoms of BD are summarized. The immunopathological changes reflect a chronic vasculitis of arterioles, venules and capillaries. The role of T-cells, but also of NK-T-cells, secreted cytokines and neutrophils is covered. For years microorganisms have been under investigation as initiating BD and, in particular, immune reactions against various microbial heat shock proteins could be an important etiological factor. It has been shown that the pathogenic gene involved in the development of BD is pinpointed to HLA-B51. Finally, the treatment of BD is discussed in detail, including new options like anti-TNF-alpha-antibodies and interferon-alpha. Immunology of Behçet's Disease summarizes our knowledge regarding the most important factors that induce or trigger BD and will stimulate research in the field and help to initiate new ideas.Table of Contents1. Epidemiology of Adamantiades-Behçet's Disease 2. A Proposal to Study the Frequency of Rare Diseases 3. Non-Ocular Manifestations 4. Ocular Manifestations in Behçet's Disease 5. Immunohistopathology of Behçet's Disease 6. T Cells in Behçet's Disease 7. Nk and Nk-T Cells Possibly Involved in Behçet's Disease 8. Cytokines in Behçet's Disease 9. Autoimmunity in Behçet's Disease 10. An Attempt To Create A Behçet's Disease Model In Mice 11. Neutrophil Hyperfunction in Behçet's Disease 12. Role of Infectious Organisms in Behçet's Disease 13. The Role of Heat Shock Proteins in Behçet's Disease 14. Association of HLA-B51 Suballeles with Behçet's Disease in Patients of German and Turkish Origin 15. Peptide Motif of HLA-B*5101 and the Linkage To Behçet's Disease 16. Microsatellite Mapping of the Pathogenic Gene of Behçet's Disease 17. The Treatment of Behçet 18. The Efficacy of Anti-TNF-Alpha Antibody in the Treatment of Uveitis Patients with Behçet's Disease 19. Use of Interferon-a in Behçet's Disease 20. Type I Interferon Treatment of Experimental Autoimmune Uveoretinitis

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Book SynopsisThis title primarily focuses on the functional mechanisms and roles of Ca2+ channels in the central nervous system, and the effects of Ca antagonists on cytosolic CA2+ by blocking voltage sensitive channels. These findings are an important contribution to understanding the mechanisms of brain dysfunctions, including Alzheimer's disease, cerebral ischemia and affective disorders, as well as the effects of cytosolic CA2+ modulators on neuronal cell death. In addition the results of clinical trials are reported using typical and atypical Ca antagonists in the treatment of neuropsychiatric diseases.An essential reference to some of the most current and vital research into Ca antagonists as therapeutic agents, this monograph is invaluable for all clinical and pre-clinical researchers active in the multidisciplinary fields of neuroscience, including: psychopharmacology, molecular biology, behavioral pharmacology, neuropharmacology, and electrophysiology and immunology. Investigators of Ca2+ dynamics and brain dysfunction especially will find this book useful in the development of novel drugs to treat neuropsychiatric diseases.

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Book SynopsisThe Idea of Consciousness examines the problem of how the working of synaptic connections might give rise to consciousness, and describes the current neuroscientific concepts and techniques used to identify and explore those parts of the brain that may be involved. This book will serve as an invaluable and stimulating introduction to the subject. Beautifully illustrated, it is a must for anyone who is curious about consciousness.Table of Contents1. An Introduction to Consciousness and the Brain 2. Syntax, Sematics and Qualia in Consciousness 3. The holistic Nature of Consciousness 4. The Consciousness of Muscular Effort and Movement 5. The Distortion of Consciousness 6. The Evolution of Consciousness 7. Consciousness and Quantum Mechanics An Epilogue: Blade Runner or Einstein?

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Book SynopsisEstrogen and the Vessel Wall marks the start of a new era in understanding the cardiovascular actions of estrogen. It examines the hypothesis, derived from a growing body of epidemiological data, that estrogen acts directly upon the vessel wall to produce beneficial effects in the cardiovascular system.Inspired by a satellite symposium of the IX International Vascular Biology Meeting, additional topics have been included, covered by leading experts. All subjects have been brought together here to produce an outstanding and integral publication, a milestone in the field of Vascular Research.Table of ContentsPart I - Regulation of Gene Expression by the Estrogen Receptor Part II - Vascular Endothelium 1. Role of Estrogen in Endothelial Cell Behaviour 2. Modulation of Cellular Adhesion Molecules and Endothelial Nitric Oxide Synthase by Estrogen 3. Non-Genomic Actions of Estrogens: Estrogens as Antioxidants Lipoprotein Metabolism in the Vessel Wall 4. Estrogen and Vasomotor Tone 5. Endothelium-Dependent Vasoconstrictors Part III - Lipoproteins, Hemostasis and Leukocytes 1. Estradiol and Accelerated Transplant Atherosclerosis 2. Statistical Analysis of Ionic Channel Current Fluctuations 3. Natural Variability in the Geometry of Dendritic Branching Patterns 4. The Multiple Equivalent Cylinder Model 5. Parameter Estimation Algorithms for the Shunt Cable Model 6. Determination of Cable Parameters for Neurons with Gap Junctions 6. Ionic Current Modeling of Neurons in the Outer Retina 7. Ephatic Interactions Between Neurons Part IV - Regulation of Vasomotor Function 1. Estrogens and Coronary Artery Reactivity in 2. Estrogen Receptor in the Cardiovascular System Part V - Atherosclerosis and Vascular Diseases 1. Atherosclerotic Monkeys 2. Cloning Expression and Function of a Novel Estrogen Receptor

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Book SynopsisMonoclonal antibodies have had their impact on biomedical research for more than a decade. Beside their exuberant use as reagents, quite a number of diagnostic and therapeutic approaches have been followed and an impressive number of technological improvements, e.g., humanization, recombinant miniantibodies, have been elaborated to strengthen the principle. With respect to clinical applications, the first generation of antibody 'drugs' is yielding promising results while second and third generation antibody constructs are already underway. The book reviews the status of technological development and brings this into the perspective of clinical results. A rapidly growing amount of clinical data is collected in an expanding number of indications. Hence, the review of clinical study results has been grouped according to the fields of oncology and of chronic and acute inflammation. This book will be of interest to scientists working in the fields of oncology, immunology, internal medicine and clinical chemistry.Table of ContentsPreface to the Series, Preface, Contributors, 1 Recombinant Antibodies: Construction and Production, 2 Bispecific Antibodies, 3 Targeted Cytotoxicity: Antibody-Drug and Antibody-Toxin Conjugates, 4 Selective Drug Delivery Using Targeted Enzymes for Prodrug Activation, 5 Immunoscintigraphy and Radioimmunotherapy, 6 Clinical Studies in Oncology, 7 Clinical Studies in Acute and Chronic Inflammation, 8 Marrow Purging and Stem Cell Preparation, Index

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Book SynopsisHighlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, risk factors such as ApoE, and transgenic animal models. Some of the latest developments in Alzheimer's disease research, including the effect of presenilin knock outs on amyloid -peptide generation, are also included.Table of Contents1. The Tau Proteins in Alzheimer's Disease 2. The Genetics of Familial Alzheimer's Disease 3. Mutations in Three Genes Are Associated with Early Onset Alzheimer's Disease 4. The Molecular Biology of Presenilin 1 5. Molecular Biology of Presenilin 2 6. Presenilin Proteins and Their Role in Development and Notch Signaling 7. Transgenic Animal Models in the Development of Therapeutic Strategies for Alzheimer's Disease 8. Amyloid Morphology and Pathology of Alzheimer's Disease 9. The Biological Activities and Function of the Amyloid Precursor Protein of Alzheimer's Disease 10. Transgenic Models of Alzheimer's Disease

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Book SynopsisThis concise, introductory handbook discusses the basic principles of medical ethics, and includes practical, realistic guidance on how to evaluate and manage common ethical problems, focusing on the care of elderly patients Typical scenarios faced in clinical practice, such as issues of mental capacity and consent, resuscitation, near death decisions, quality of life, and health care expenditure, are discussedTable of ContentsPrinciples of medical ethics; determining mental capacity and competence; informed consent; advance directives; decisions on life-sustaining therapy - nutrition and fluid; cardiopulmonary resuscitation; achieving "a good death"; the use of physical restraints; ethical issues in dementia; ethical issues in stroke management; quality of life in health care decisions; ethical issues and expenditure on health and social care.

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Book SynopsisBiological Clocks introduces the subject of human chronobiology. It describes biological clocks; why we have clocks; how biological clocks relate to sleep disorders, depression, and jet lag; and how the reader can measure his/her own rhythms.Table of ContentsBIOLOGICAL RHYTHMS: Fooling Around With Time. More Seriously. Methods of Rhythm Measurement. Entrainment. Freeruns. More Related to Freeruns. Resetting. Can Clock Be Stopped? Temperature and Chemicals. Seasons and Photoperiodism. Circarhythms. Biological Clockworks. Human Rhythms. The End of the Whole Mess. APPNEDICES: Glossary. Societies. Journals. Software. Bibliogrphy. MEASURE YOUR OWN CIRCADIAN RHYTHM.

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Book SynopsisThis book is intended for specialists of B-cell immunology. It investigates such topics as movement of a monoclonal antibody from the laboratory into the clinic, the field of Fc receptors, and the impact of monoclonal antibodies on the diagnosis and treatment of human diseases.Table of ContentsIntended for specialists in B cell immunology, this volume investigates such topics as the movement of a monoclonal antibody from the laboratory into the clinic, the field of Fc receptors, the impact of monoclonal antibodies on the diagnosis and treatment of human cancer, and detailed analyses of specific antibody systems: mouse lambda and human kappa.

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Book SynopsisMost brain related activity has focussed on specialized interests within individual disciplines. Recent multidisciplinary activity has provided the impetus to break down these boundaries and encourage a freer exchange of information across disciplines. This text reflects these developments. It spans the landscape of brain science to provide core information from 12 disciplines (including evolution, philosophy, anatomy, chemistry, computer science, brain dynamics, psychology, neurology, psychiatry, psychotherapy and brain imaging).In outlining how and why it is now possible to realistically model aspects of the brain's dynamics from such a wide range of intellectual endeavors, this book will prove itself useful to undergraduates, postgraduates and all those seeking a contemporary perspective and evaluation of the current status and future directions in the brain sciences.Table of Contents1. Integrative Neuroscience: The Big Picture 2. Overview of Chapters 3. Evolution of the Human Brain 4. The Mind-Brain Problem 5. A Cellular Perspective of Neural Networks 6. The Brain's Chemistry 7. The Brain's Anatomy 8. Sensory-Motor Models of the Brain 9. Computer Models of the Brain 10. Brain Dynamics: Modeling the Whole Brain in Action 11. Brain Dynamics: Brain Chaos and Intentionality 12. Models of the Brain in Neurology 13. Models of the Brain in Psychology 14. Models of the Brain in Psychiatry 15. Brain-Mind in Psychotherapy 16. Human Brain Imaging Technologies

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Book SynopsisThe past few years have seen considerable advances in our understanding of the molecular basis underlying cutaneous cell adhesion mechanisms. Co-authored by a number of leading experts in the field ^Cell Adhesion and Migration in Skin Disease provides a comprehensive overview of the critical role played by cell adhesion in determining the structure and function of both healthy and diseased human skin. The book is divided into three main sections, with each one addressing a principal function of adhesion molecules.The first part focuses on the epidermis, which as the skin's outermost layer, acts as the human body's primary barrier of defence. Roles played by cytoskeletal intermediate filaments and junctional complexes in cutaneous cell adhesion are emphasised with descriptions of blistering skin diseases that can arise if these molecules malfunction.The second part describes the macromolecular interactions responsible for the anchorage of cells to the underlying extracellular basement membrane. The experimental approaches detailed in the text not only reveal how the molecular components of the dermal-epidermal junction have been elucidated, but also highlight how mutations in the genes which encode these molecules are responsible for many heritable skin diseases. Leukocytes continually infiltrate the skin and patrol it for potentially harmful pathogens. Control of leukocyte adhesion to resident cells within the skin and to the extracellular matrix plays a key role in controlling these processes. These mechanisms constitute the primary focus of the final section. The pivotal role of leukocytes is examined in conjunction with the chronic inflammatory diseases which arise when components of the skin's finely tuned defence strategy go awry and the potential for these anomalies to be pinpointed as important immunotherapeutic targets for skin diseases.Table of Contents1. Cell-Cell Attachment 2. The Cornified Cell Envelope 3. Keratins and Keratin Disorders 4. Desmosomes 5. Cell-Matrix Attachment 6. Protein-Protein Interactions at the Dermal-Epidermal BMZ 7. Biology and Pathology of Hemidesmosomes 8. Dermal-Epidermal Adhesion 9. Leukocyte Trafficking in Skin Diseases 10. Skin Homing Lymphocytes 11. T-cell Accessory Molecules 12. Animal Models of Skin Inflammation 13. Langerhans Cell Migration 14. Leukocyte Adhesion and Accessory Molecules as Therapeutic Targets for Inflammatory Skin Diseases

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Book SynopsisIn the last decade the use of interstitial microwave antennas to deliver localized and controlled power to deep-seated tumours has been explored in institutes around the world. Simultaneously the field of brachytherapy also progressed as clinicans began to develop new implantation approaches for a variety of tumour sites, thereby promoting the insertion of catheters which could serve as conduits for the insterstitial microwave applicators. Although the challenges presented by deep-seated tumours have not been solved, the developments in the field of brachytherapy and the implantation of interstitial applicators for hyperthermia are such that a volume dedicated to this approach is warranted. This third volume in the series Hyperthermia and Oncology provides insight in and updated information on various aspects of interstitial hyperthermia. It aims to serve as a guide for clinicians who are either already working in the field or who wish to implement this treatment. It also provides basi

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Book SynopsisTo correctly diagnose a human organism with the help of acoustic waves is impossible without knowledge of the physics of acoustic waves interaction with the issues of the organism. This book is dedicated to the given problem. It consists of four sections, the first of which deals with physical models of the biological issues used in ultrasonic diagnostics. In the other sections the basic stages of ultrasonic diagnostics (sound radiation, sound scattering, depictions visualization) are studied. It is shown how different bodies and issues of a human organism scatter acoustic waves and how, using the scattered wave, one learns about what happens with some body or issue.Trade ReviewVery didactically organized, with ample attention for mathematical detail, which nowhere becomes so complicated that it obscures the physics behind it [...] The first three chapter give a thorough but accessible description of the physics of ultrasonic pulse-echo imaging, while the fourth discusses the possible methods to apply these data for 2D, 3D or time-dependent imagery [...] This book is a useful addition to the ultrasonic imaging literature, stepping into the - rather large - gap between more engineering-oriented texts and theoretical works. G. van Soest, PhD; Biomedical Engineering, Thorax center, Erasmus MC Rotterdam, the NetherlandsTable of ContentsINTRODUCTION Chapter 1. MODEL 1.1. Biological Tissue as a Homogeneous Continuum 1.2. Types of Biological Continua 1.3. Organism as a Heterogeneous Continuum 1.4. Equations of Motion of Biological Continua 1.5. Physical Nature of Ultrasonic Diagnostics Chapter 2. EMISSION 2.1. Unbounded Plane Emitter 2.2. Point Emitter (Monopole) 2.3. Bounded Plane Emitter 2.4. Point Emitter (Dipole) 2.5. Generation of Acoustic Oscillations Chapter 3. SCATTERING 3.1. Nature of a Scattered Wave 3.2. Immobile Large-Scale Inhomogeneities 3.3. Immobile Large-Scale Inhomogeneities with Boundary Layer 3.4. Immobile Small-Scale Inhomogeneities 3.5. Immobile Mesoscale Inhomogeneities 3.6. Mobile Inhomogeneities 3.7. Systems of Scatterers Chapter 4. VISUALIZATION 4.1. What Is Visualization? 4.2. Modes of Visualization 4.3. Defects of Acoustic Images AFTERWORD

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Book SynopsisBiomaterials are produced in situ and in vivo in the body using mainly hydration reactions, that is, reactions between phosphates, silicates or aluminates, and water. The nanostructural integration of these biomaterials in the body is controlled by six mechanisms. This book describes the new biomaterials based on nanostructural chemically bonded bioceramics and discusses their general and specific properties. It presents an overview of the nanostructural chemically bonded bioceramics, including their processing aspects, properties, integration with tissues, relation to other bioceramics and biomaterials, and nanostructural integration in different dental and orthopaedic applications. Trade Review"This book describes a new family of in situ in vivo produced bioceramics with high potential within dentistry and orthopedics. The importance of nanostructural properties is thrilling, and thoroughly described." —Prof. Roger Narayan, North Carolina State University, USA"This book is an excellent introduction to the field of bionanomaterials for the researcher as well as the newcomer to the field. It introduces readers to the structure and characteristics of new bioceramics, chemically bonded nanobioceramics, and their interaction with tissues in vivo and in vitro, posing the question: What determines the biocompatibility and the toxicity of such new inserts in human bodies? The book thoroughly explains chemically bonded bioceramics from a chemical composition and mineralogy point of view and early tissue response, providing researchers with comprehensive knowledge about nanobioceramics for practical applications."—Walid M. Daoush, Helwan University, EgyptTable of ContentsIntroduction to Nanostructural Chemically Bonded Bioceramics. Classification of Bioceramics. General Properties. Specific Properties. Nanostructural Mechanisms and Integration to Hard Tissue. Nanostructures Including Nanoporosity. Applications. Future Trends.

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Book SynopsisNanoparticles may be used in industrial processes, incorporated into consumer products, or applied as biomedical agents. Isotopic (radio)labeling is one of the most powerful methods for nanoparticle tracing in experimental studies. This book presents an introduction to some commonly used nanomaterials, describes various methods with which they may be radiolabeled, and provides illustrative examples of applications of the labeled particles. Finally, it discusses the use of nanomaterials in radiotherapy, the stable isotope labeling technique, and operational health and safety aspects related to the manipulation of nanoparticles in controlled areas. The book will appeal to anyone involved in nanotechnology, molecular imaging, radiochemistry, and nanomedicine. Trade Review"This book is very comprehensive and timely, particularly because nanomaterials are being more widely used in numerous applications across society. It endeavors to be a comprehensive resource for scientists at all levels in the fields of nanomaterials and radiochemistry—and those who wish to learn about them. It is artfully constructed and leads us through available labeling strategies and the associated complexities of the multiple methods available for the preparation of radiolabeled nanomaterials. I fully recommend this book."—Dr. Jason S. Lewis, Memorial Sloan Kettering Cancer Center, USA"This book is an excellent companion for everybody who works with radioisotopes and nanomaterials, or who wants to start in this emerging field. The book gives a comprehensive overview from the basics of nanomaterial preparation, over radiolabeling procedures, to biomedical applications and imaging. Each reader, from senior researcher to graduate students, will enjoy this book as reference work or as study book, respectively."—Prof. Dr. Tobias L. Ross, Hannover Medical School, GermanyTable of ContentsIntroduction. Inorganic Nanoparticles. Oxide and Bioceramic Nanoparticles. Graphene, Carbon Nanotubes, and BCN Nanostructures. Polymeric Nanoparticles: Description, Synthesis, and Applications. A Brief Overview of Radioactivity. In vivo Evaluation of Nanoparticle Pharmacokinetics by Molecular Imaging: Technical Aspects. Radiolabelling of NPs Using Radiometals: 99mTc, 68Ga, 67Ga, 89Zr, and 64Cu. Radiolabelling of Nanoparticles Using Radiohalogens, 13N, and 11C. Radiolabelling of liposomes. Direct Ion-Beam Activation of Nanoparticles. Neutron Activation of Nanoparticles. 7-Beryllium-Recoil Labelling of Nanoparticles. Calculation Tools for Isotope Production by Beam Activation. Synthesis and Applications of Alpha/Beta Emitter-Labelled Nanoparticles. Radiochemical Stability Studies of Radiolabelled Nanoparticles. Labelling Nanoparticles with Non-radioactive Isotopes. Health and Safety Considerations for Radiolabelled Nanoparticles.

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Book SynopsisThis book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy, or precision medicine, or personalized medicine is becoming a standard treatment for many diseases, including cancer. However, how much do we know about the personalized medicine approach? This lucid book helps undergraduate and graduate students, professional researchers, and clinicians to better understand the key concept of personalized medicine.The most up-to-date topics on personalized medicine in this book cover the recent trends in and updates on lung, gastric, liver, breast, and other types of cancers. Circulating tumor cell, cell-free circulating DNA, and microRNAs are discussed as new diagnostic and prognostic markers for cancer. The avatar mouse model is also discussed for maximizing treatment efficacy and prognosis prediction, and so is microenvironment as a drug resistance mechanism. With classical and new pathological approaches, the book provides a systemic overview of personalized immunotherapies and hyperthermic intraperitoneal chemotherapy, followed by new emerging fields of hereditary cancer, thereby equipping readers to eventually contribute in developing more advanced tools and therapies for curing cancer.Trade Review"Likely as the recent Cancer Moonshot Initiative highlights, this book well describes the importance of genetics/genomics-based personalized therapies to improve cancer treatments. This field is growing rapidly, and it is certain that many scientists should obtain professional knowledge of ‘cancer precision medicine’ to cure more cancer patients."—Prof. Yusuke Nakamura, University of Chicago, USA"At a time when an explosive increase in data has combined with rapidly evolving treatment paradigms, it has become particularly challenging for modern clinicians and medical researchers alike to put these advances in knowledge and practice into a proper context. It is in light of this predicament that this new volume edited by Dr. Il-Jin Kim provides a much-needed organization and harmonic understanding to the cacophony of information regarding the elusive realm of precision medicine. Covering an exhaustive array of topics ranging from the basic science of tumor modeling to the biology of tumor microenvironments to the horizon of cancer immunotherapy and advances for specific cancer types, this clearly written and very readable compilation provides a solid foundation for comprehending the rapidly advancing dawn of a truly new, personalized, precision approach to the treatment and, hopefully, the cure of cancer."—Prof. Michael J. Mann, University of California, San FranciscoTable of ContentsPersonalized Medicine for Cancer: Introduction and Overview of the Book. Personalized Medicine in Lung Cancer. Genome-Based Personalized Medicine in Liver Cancer. Applications of Circulating DNA Analysis in Personalized Medicine. Circulating Tumor Cells and Personalized Medicine. Mouse Models in Personalized Cancer Medicine. Tumor Microenvironment, Therapeutic Resistance, and Personalized Medicine. Personalized Immune Therapy. Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Peritoneal Malignancies. Personalized Medicine in Hereditary Cancer Syndromes. Pathology in the Era of Personalized Medicine. MicroRNAs in Human Cancers. Pharmacogenomics of Tamoxifen.

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Book SynopsisThis book is the first in a series compiling highly cited articles in nanomedicine recently. The series is edited by Lajos P. Balogh, a prominent nanotechnology researcher and journal editor. The first book content is about nanotechnology in cancer research. It also includes a wide variety of must-know topics that will appeal to any researcher involved in nanomedicine, macromolecular science, cancer therapy, and drug delivery research. These 31 articles collected here have already acquired more than 3500 citations (i.e., over a hundred on average), highlighting the importance and recognized professional interest of the scientists working in this field. Table of ContentsNanotechnology Platforms and Physiological Challenges for Cancer Therapeutics. Nanostructure-Mediated Drug Delivery. Nanoparticles: A Boon to Drug Delivery, Therapeutics, Diagnostics and Imaging. Emerging Nanopharmaceuticals. Significance of Synthetic Nanostructures in Dictating Cellular Response. Electrospun Bioscaffolds That Mimic the Topology of Extracellular Matrix. Preparation of Drug-Loaded Polymeric Nanoparticles. In vivo Tumor Suppression Efficacy of Mesoporous Silica Nanoparticle-Based Drug Delivery System: Enhanced Efficacy by Folate Modification. Update on Nanoparticle-Mediated Immune Mechanisms for Dendritic Cell-Based Targeted Immunity and Cancer. Curcumin-Loaded γ-Cyclodextrin Liposomal Nanoparticles as Delivery Vehicles for Osteosarcoma. Influence of Purity and Surface Oxidation on Cytotoxicity of Multiwalled Carbon Nanotubes with Human Neuroblastoma Cells. Hollow Chitosan-Alginate Multilayer Microcapsules as Drug Delivery Vehicle: Doxorubicin Loading and in vitro and in vivo Studies. ZnO Nanorod-Induced Apoptosis in Human Alveolar Adenocarcinoma Cells via p53, Survivin and bax/bcl-2 Pathways: Role of Oxidative Stress. Camptothecin in Sterically Stabilized Phospholipid Micelles: A Novel Nanomedicine. Photoablation of Glioblastoma Stem Cells by Single-Walled Carbon Nanotubes Functionalized with CD133 Antibody. Surface Chemistry Influences Cancer Killing Effect of TiO2 Nanoparticles. Endocytosis of Titanium Dioxide Nanoparticles in Prostate Cancer PC-3M Cells. Multi-Walled Carbon Nanotube Exposure Alters Protein Expression in Human Keratinocytes. Carbon Nanotubes as Functional Excipients for Nanomedicines: I. Drug Delivery and Biocompatibility Issues. Carbon Nanotubes as Functional Excipients for Nanomedicines: II. Pharmaceutical Properties. Fluorescence Intensity and Lifetime Imaging of Free and Micellar-Encapsulated Doxorubicin in Living Cells. Doxorubicin-Loaded Solid Lipid Nanoparticles to Overcome Multidrug Resistance in Cancer Therapy. PEGylated PLGA Nanoparticles for the Improved Delivery of Doxorubicin. Gold–Doxorubicin Nanoconjugates for Overcoming Multidrug Resistance. In vitro Evaluation of Novel Polymer-Coated Magnetic Nanoparticles for Controlled Drug Delivery. Targeting of Albumin-Embedded Paclitaxel Nanoparticles to Tumors. Viral Nanoparticles as Platforms for Next-Generation Therapeutics and Imaging Devices. Beta-Casein Nanovehicles for Oral Delivery of Chemotherapeutic Drugs. Classification of Lung Cancer Histology by Gold Nanoparticle Sensors. Enhancement of Radiation Effects by Gold Nanoparticles for Superficial Radiation Therapy. Radioactive Gold Nanoparticles in Cancer Therapy: Therapeutic Efficacy Studies of GA-198AuNP Nanoconstruct in Prostate Tumor–Bearing Mice. The Present and Future of Nanotechnology in Human Health Care.

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Book SynopsisThis book focuses on the conventional and emerging applications of radiations, which include radio waves and ultraviolet and gamma radiations. It discusses new techniques in radiation therapy and the effects of ionizing radiations on biological systems. The applications of radiations in the synthesis and use of nanoparticles along with the effects of hypergravity indicate a new trend. The book offers a concise account of the latest studies carried out so far and shows the new initiatives to be undertaken in the field of medicine and biology. It covers the medical use of radiations, such as ferrous sulfate–benzoic acid–xylenol orange dosimetry, Co-60 tomotherapy, radio-electro-chemotherapy, and fractional radiotherapy, and radiobiological effects, such as the effects of cell phone radiations on human health parameters and the combined effects of radiations and hypergravity on plants.Trade Review"I congratulate all involved in this book for taking a step that has the potential to show direction to young physicists what lies ahead, a vast ocean indeed, when they enter the arena of bio-medical sciences. Happy reading."—Dr. Madan M. Rehani, Massachusetts General Hospital, Harvard Medical School, USA"I am immensely impressed with the wide range of frontline topics covered in this fascinating book devoted to cancer radiotherapy. Needless to say, the rich contents of the book will prove to be a good reference and will help catalyze future advances in the improvement of the radiation therapy of cancer patients."—Dr. K. P. Mishra, Former Senior Scientist and Head, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, India"This book provides an updated outlook on the conventional applications of radiation, from radio waves to UV and gamma-ray, in the context of therapy and effects of ionizing radiation to biological systems. As part of this update, the medical use of radiation such as DBX dosimetry, cobalt-60 tomotherapy, RF electrotherapy, fractional radiotherapy, and radiobiological effects are also covered. Two new contributions made by this edited book are the discussions on emerging applications of nanoparticles and hypergravity."−Silvano Donati, University of Pavia, Italy Table of ContentsGeneration of Bremsstrahlung Radiation from Different Low- to High-Z Targets for Medical Applications: A Simulation Approach. The Investigation of Cobalt-60 Tomotherapy. Ferrous Sulfate–Benzoic Acid–Xylenol Orange Chemical Dosimetry System in Radiotherapy. Radiobiological Effects in Fractionated Radiotherapy of Head and Neck Squamous Cell Carcinoma Patients. Radio-Electro-Chemotherapy of Cancer: New Perspectives for Cancer Treatment. Motivation to Explore New Techniques for Synthesis of Metal Nanoparticles and Their Immense Importance in Biological and Medicinal Applications. Gold Nanoparticle–Assisted Radiation Therapy. The Combined Effect of Hyper-Gravity and Gamma-Irradiation on Physiology of Wheat Seedlings. The Study of the Effect of UV-C Radiation on the Current–Voltage Characteristics of Chitosan Membranes. Investigating Effects of Radiation Due to Cell Phones on Health Parameters of Youngsters during Continuous Conversation.

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Book SynopsisPart ?: Clinical conundrums.- 1. Reversible cause of coma in a previously healthy adult : The miraculous recovery.- 2. A Group of People Presenting with Gastrointestinal Symptoms and Blurring of Vision: Mass Casualty.- 3. Patient presenting with vomiting, hypovolemia, Kussmaul’s breathing and normal blood sugars – Pratik decides to party!.- 4. Sudden Death in Polar Climes : The Arctic Trek.- 5. Rash and neuropathy in an adult male: The retreat by the Ganges.- 6. Fatigue and gait disturbance: The failed assassination.- 7. Cluster of Unexplainable Symptoms: The Hysterical Wife.- 8. Adult male with muscle ache& difficulty in moving - Heavy Fuel.- 9. Young woman with agoraphobia, anxiety and difficulty in ambulation: Frankenstein’s sister.- 10. Dysphagia in a young male with no pallor or lymphadenopathy – Hard to Swallow.- 11. Adult male presenting with anxiety, palpitations and diaphoresis - Anxious Allen.- 12. Cluster of Patients with Unexplained Jaundice : The Great Indian Wedding.- 13. Adult Male Presenting with Left Foot Drop and Tingling Numbness both Feet: Nervous Norman.- 14. Sudden loss of consciousness in a fit, young patient: The cricketer who collapsed.- 15. Tachycardia, Hypotension and Agitation in A Post-Partum Mother: The Mother in Distress.- 16. Young lady with abdominal cramps and difficulty in breathing : The shy bride.- 17. Adult male admitted to intensive care unit with tachycardia, hypertension and agitation : It’s where my demons hide.- 18. Fever, rash and arthritis in a young female: Andrea is angry!.- 19. Young female with polyuria: The painful co-passenger.- 20. Disproportionate Fatigue and Abdominal Pain in An Adult Male with Cirrhosis     and Portal Hypertension - Sometimes The Hoofbeats Are Zebras.- 21. Subacute onset of Apathy and fatigue in a previously well male: The apathetic attender.- 22. Hirsutism in women : Hairy Harini.- 23. Commonly Missed Diagnoses in The Elderly : The Quiet Grandma.- 24. Dizziness, Blurred Vison and Slurred Speech : The Depressed Decorator.- 25. Middle aged male with burning sensation at fingertips and rash – The Alpha gal and her husband.- 26. Bone, skin and GI symptoms in a young female : The bachelorette party.- 27. Fever and rash in a traveller: The catastrophic rash.- 28. Loose Stools, Breathlessness and Blurring of Vision in a Previously Healthy Person: The Girl who Felt Guilty.- 29. Face swelling and abdominal pain in a young female – Anagha’s absenteeism.- 30. Family clustering of vague symptoms and neurological signs : The depressed worker.- 31. Blurring of Vision and Eye Pain in A Young Male: The Man from Myanmar.- 32. Loose Stools and Constipation in a Stressed Executive – cut it out.- 33. Daytime sleepiness , anemia and hepatomegaly in a middle aged female : Shauli’s somnolence.- 34. Loss of Libido in a Previously Healthy Male : The Unfulfilled Wife.- 35. Elderly male with backache & restricted movement :The Security Guard Who Always Stood Straight.- 36. Polydipsia, polyuria and pruritus – the paan chewing Babu.- 37. Gum bleeding, tinnitus and fatigue: The bloody apple.- 38. Elderly Patient with Pruritus, Splenomegaly and Constitutional Symptoms: Itchy Ignatius.- 39. Low mood and multiple disparate somatic complaints : Morose Monroe.- 40. An adult male with diverse haematological, skeletal and skin anomalies - Thimma with thrombocytopenia.- 41. Life threatening disease acquired in the wilderness : the sick spelunker.- 42. Collapse while standing at a live performance – the deadly laugh.- 43. Acneiform Eruptions and oral ulcers in a Young Adult Male - Acne Angst.- 44. Elderly male with difficulty in swallowing, unsteadiness of gait and slurred speech : The sad reunion.- 45. Headache, Diplopia and Drowsiness in a previously Healthy Young Female: The Pernicious Pimple.- 46. Post Coital headache - Not tonight, John.- 47. Subacute confusion in the previously well : the muddled model.- 48. Acute confusion in an elderly gentleman : Grandad in the department store.- 49. Headache and seizures in a previously healthy female: The Sceptical Husband.- 50. Complicated course of an adult patient admitted with hiccup, vomiting, and altered sensorium - Pass the salt please.- Part ?I: Call the Lab.- 51. Monitoring glycemic status in patients with end stage renal disease.- 52. High Creatinine and Very High Urea : The Risk of Roadside Munchies.- 53. Fatigue & hiccup in an elderly lady : weakness is not a symptom of normal aging!.- 54. Patient on regular MHD presents with carpopedal spasm : Post-holiday blues.- 55. Fever, Body Ache And Decreased Urine Output : The Flu That Wasn’t A Flu.- 56. Young Lady With Possible Drug Overdose Admitted With High Anion Gap Metabolic Acidosis : Danger in the dormitory.- 57. Sudden deterioration in malnourished female : The Peril of Good Intentions.- 58. Anemia , rash and jaundice in a young woman.- 59. Patient admitted with exacerbation of bronchial asthma does not improve : lab report trends are more important than numbers.- 60. Lung cancer with bone metastasis : unexpectedly normal calcium values.- Part ?II: Short Puzzles.- 61. Fluctuating somatic and psychological complaints in a new mother - The Worried Grandmom.- 62. Hypoglycemia not reverting with sugar: The unexplained hypos.- 63. Ascending weakness with no sensory signs in a 5 year old girl – Holiday blues.- 64. Middle aged male meets with an accident while driving on a straight well-lit empty road : The improbable accident.- 65. Middle aged male concerned about verruca - Just a wart?.- 66. Transfusion dependent adolescent presents with rhinorrhoea and epistaxis : The Troubled teen.- 67. Weakness of limbs and difficulty in swallowing after an attack of gastroenteritis :  Supercilious Sanjay.- 68. Cardiovascular deterioration after sexual intercourse : The happy couple.- 69. Middle aged male with varicocele – The bag of worms.- 70. Altered Behaviour and Agitation in a Post Operative Patient : The Bike accident.- 71. Refractory shock after trauma –  the bloody biker.

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Book SynopsisHelping the Stork The sourcebook for all the information parents-to-be need to know about the choices and challenges of donor insemination Each year donor insemination (DI) offers a pathway to parenthood for the hundreds of thousands who turn to family-building alternatives. Although DI is considered as often as adoption, couples facing male infertility, as well as single women and lesbian couples, have had few places to turn for information about this method, which has been shrouded in secrecy. In Helping the Stork, parents-to-be, as well as friends and family, doctors, and counselors, can explore the choices and challenges raised by this alternative to overcoming childlessness. This comprehensive handbook moves through each step of the process: reaching a solid decision about whether donor insemination is the best choice for a family's future; handling the difficult issue of privacy; selecting a donor and getting started; and learning to thrive as a family meeting DI's added challengTable of ContentsA Note on Terminology. Introduction. Chapter One--Family Building: DI as an Option. Chapter Two--Facing Tough Choices. Chapter Three--Understanding Your Donor Options. Chapter Four--Getting Started. Chapter Five--Trying Times: When Donor Insemination Takes Its Time. Chapter Six--Becoming Pregnant: Shock, Relief, Fear, and Joy. Chapter Seven--Growing with DI. Chapter Eight--Changing Families, Different Challenges. Chapter Nine--Guiding Those Who Care: Advice for Confidants. Chapter Ten--Humor in Hindsight. Resources. Endnotes. Bibliography. Index.

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Book SynopsisBringing together colorful historical vignettes, social and anthropological theory, and quantitative analyses, this title examines these interactions between the Khmer, Cham, and Vietnamese of Cambodia and the French, documenting the differences in their understandings of medicine.Trade Review"Mixed Medicines is just the sort of book that the field of colonial medicine has been clamoring for. It offers much more than a study of the imposition of French colonial medicine on the Khmer people of Cambodia; it show us why people 'mix' health care practices in ways that make sense to them but baffle others. This brilliant book will inform scholars and policymakers alike." (Ken Alder, Northwestern University)"

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Book SynopsisExplores some of the mysteries and complexities of medicine while untangling the inherent conundrums of scientific research and highlighting its vagaries. This book considers the prevalence of tonsillectomies, the placebo effect and randomized control trials, bogus doctors, efficacy of vitamin C in fighting cancer and the chronic fatigue syndrome.Trade Review"Collins and Pinch carefully tease out key conflicts in the way that medical knowledge is constructed and used and endeavor to show how necessarily complicated medical decision making must be....The authors neither jump on the critical bandwagon nor apologize for medicine's failings, rather they show that the inherent discrepancy between the pace of medical discovery and the need for immediate succour is one that must be addressed jointly by physician and patient." - Noah Raizman, Lancet "The writing is interested, intelligent, and explanatory....Much of the book's quality comes from its steady, generally clear-sighted explanation of some of the ordinary within medicine." - Druin Burch, Times Literary Supplement"

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Book SynopsisHelps you explore how practitioners established a new style of practice, at the center of which lies the cancer clinical trial. Far from mere testing devices, this book features trials that have become full-fledged experiments that have redefined the practices of clinicians, statisticians, and biologists.

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Book SynopsisThrough engaging narratives of illness, medical work, and nursing in which people choose to act in ways that affirm their humanity, this book depicts the transformation of demoralized medicine into caring relationships through generosity - generosity towards both others and oneself. It demonstrates how generosity is renewed through dialogue.Trade Review"Frank's vision of how a lost sense of story could be restored to medicine is both lucid and profound.... In his new book, The Renewal of Generosity, he examines clinical situations in which health care workers who do bring a sense of narrative to bear have transformative effects." - Melanie Thernstrom, New York Times Magazine "This reflection is starkly honest and never pedantic or condescending.... Through a rich telling of stories and reflection on them, Frank conducts a complex symphony of ideas about medicine with writing from a wide range of authors that models how readers might enact and experience the complex, subtle meaning of generosity and gratitude in their own practices.... Physicians should rush to read this book, and I hope that patients will join them." - George J. Agich, New England Journal of Medicine"

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Book SynopsisTraces how disabled people came to be viewed as biologically deviant. This book explains how disabled people are instrumental to charting the passage from a disciplinary society to one based upon regulation of the self. The author reveals cracks in the social production of human variation as aberrancy.

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Book SynopsisThrough a combination of interviews with nurses, doctors, and chaplains across the United States and close observation of their daily routines, the author takes readers inside major academic medical institutions to explore how today's doctors and hospitals address prayer and other forms of religion and spirituality.Trade Review"The blend of historical, archival research, in-depth interviews and participant observation, and visual analysis of archaeology and design is powerful. Wendy Cadge's attempts to make sense of this peculiar yet dominant social world will be enthusiastically received." (Elizabeth M. Armstrong, Princeton University)"

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a huge range and FREE tracked UK delivery on ALL orders.

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Book SynopsisTrade ReviewDonna Dickenson's book offers a compelling and overarching framework for interpreting new trends in biomedical science, such as gene biobanks, pharmacogenetics, and the banking of cord blood. It forces the reader to ask whether every new technological advance in medicine truly betters the field-and for whom. -- Sheldon Krimsky, Tufts University Few words have as much ethical clout these days as that of 'choice,' a word that can be construed as the centrality of 'me.' Donna Dickenson's splendid book shows how deeply the 'me' has become embedded in medicine and abetted by the seemingly unchallengeable ethical concept of autonomy. What we have lost is the importance of 'we.' Using personalized medicine as her point of departure, she brilliantly works her way through a range of recent medical developments to show the damage the dominance of 'me' can bring. Her book can help restore the 'us' that has been diminished. -- Daniel Callahan, cofounder and president emeritus of The Hastings Center and author of The Roots of Bioethics: Health, Progress, Technology, Death In this timely book, Dickenson levels trenchant criticism at the poster child of the twenty-first-century biomedical establishment: 'personalized medicine.' Analyzing an impressive array of practices in the new life sciences, she makes a persuasive argument that, as personalized medicine unfolds, market values and individualism are trumping the ideals of public health. This book comes at a critical moment. As we reappraise the social contract of health care, this book helps better direct research and development towards the common good. -- David Winickoff, University of California, Berkeley Donna Dickenson's book is a seminal philosophical examination of the enthusiastic embrace of 'personalized medicine,' questioning easy assumptions about its benefits for patient care and for public health. Dickenson sounds powerful warnings about the extent to which personalized medicine risks confusion with individual self-interest and the devotion of biotechnology for private gain. -- Leslie Francis, University of Utah, co-author of The Patient as Victim and Vector: Bioethics and Infectious Disease Recognizing that there are trade-offs in how we conceptualize medicine as either driven and developed for the common good or specialized for the individual, Dickenson offers an important examination of contemporary medicine and a beautifully written account of what is at stake when the common good is overlooked. Hands down, she is one of the most insightful contributors to law and medicine discourse, and this book is a must-read for everyone concerned about the future of biotechnology. -- Michele B. Goodwin, University of Minnesota, and editor of Baby Markets: Money and the New Politics of Creating Families If you are wondering what to make of personalized medicine's grand claims, let Dickenson be your guide. Turning her keen scientific and political intelligence to biotech visions of individually tailored drugs, consumer gene tests, enhancement technologies, and more, she finds tidbits of hope for improving health care among scads of hype-some of it dangerous. This must-read book makes a powerful case for taming market domination and 'me-centeredness' and for renewing our commitments to public health and the common good. -- Marcy Darnovsky, executive director, Center for Genetics and Society Dickenson's mapping out of this vital fork in the road is valuable. Publishers Weekly This book is filled with clearly explained, hard science, giving equal treatment to the benefits and problems of personalized medicine... I recommend expending the necessary reading effort not only for healthcare workers but for the general public. New York Journal of Books Dickenson's greatest achievement in this book is that she largely succeeds in creating a coherent, compelling narrative across the five disparate case studies and that she does so incorporating insights from a range of domains including sociology, ethics, philosophy, law and biomedicine. -- Michael Morrison New Genetics and SocietyTable of ContentsPreface 1. A Reality Check for Personalized Medicine 2. "Your Genetic Information Should Be Controlled by You": Personalized Genetic Testing 3. Pharmacogenetics: One Patient 4. "Your Birth Day Gift": Banking Cord Blood 5. Enhancement Technologies: Feeling More Like Myself 6. "The Ancient, Useless, Dangerous, and Filthy Rite of Vaccination": Public Health 7. Reclaiming Biotechnology for the Common Good Notes Bibliography Index

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Book SynopsisFrom the author of the landmark bestseller The-Thirty-Six-Hour-Day comes a lucid, engaging, and nuanced treatment of one of the essential questions in science, medicine, and life: "Why?"Trade ReviewPeter Rabins shows incredible breadth of knowledge and his thesis-that there are three distinct approaches to causation, appropriate for different types of questions-is compelling. His writing is engaging, and the subject matter is deeply relevant. -- Simon Levin, Princeton University, author of Fragile Dominion: Complexity and the Commons Peter Rabin's book draws upon science, statistics, philosophy, and religion to stretch readers' thinking about the 'why' and 'how' of what happens. It provides a remarkably lucid synthesis of diverse ideas about causality based on superb scholarship and is always entertaining. I heartily recommend it. -- David Reuben, MD, David Geffen School of Medicine, University of California, Los Angeles From the two year old child's endlessly nested 'why' questions to the Old Testament and the modern scientist, and through many philosophers in between, Peter Rabins takes us on a fascinating quest in search of answers to that seemingly simplest of all questions: Why? Simple but enigmatic because, like the two year old, how do we know when to be satisfied and how do we know when we know? Throughout The Why of Things, Rabins examines fundamental aspects of how we know-or don't. In his erudite yet accessible book, readers will learn everything from philosophical categorization to nonlinear dynamics in a way that will suddenly make sense, even if they never do find out exactly why. -- Stuart Firestein, Columbia University, author of Ignorance: How It Drives Science if you're looking to learn how to better reason things out through logic and comparative analysis, then this one may be for you. Lifelong Dewey Blog Quite simply, wow. This is one of the most complex, mind-boggling and ultimately satisfying books I have read in a very long time. The Garden Window Blog A most enjoyable read and source of inspiration. The book constitutes a noteworthy addition to Professor Rabins' academic production... Philosophers of science - and perhaps more specifically philosophers interested in causality, explanation, or medicine - would gain a lot in reading it. MetascienceTable of ContentsPreface Introduction 1. Historical Overview: The Four Approaches to Causality 2. The Three-Facet Model: An Overview 3. The Answer Is Either "No" or "Yes": Causality as a Categorical Concept 4. Probabilities 5. A Third Model of Causality: The Emergent 6. Empirical: The Physical Sciences 7. Empirical: The Biological Sciences 8. Empirical: Epidemiology 9. Narrative Truth: The Empathic Method 10. Cause in the Ecclesiastic Tradition 11. Seeking the Why of Things: The Model Applied References Index

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Book SynopsisFrom the author of the landmark bestseller The-Thirty-Six-Hour-Day comes a lucid, engaging, and nuanced treatment of one of the essential questions in science, medicine, and life: "Why?"Trade ReviewPeter Rabins shows incredible breadth of knowledge and his thesis-that there are three distinct approaches to causation, appropriate for different types of questions-is compelling. His writing is engaging, and the subject matter is deeply relevant. -- Simon Levin, Princeton University, author of Fragile Dominion: Complexity and the Commons Peter Rabin's book draws upon science, statistics, philosophy, and religion to stretch readers' thinking about the 'why' and 'how' of what happens. It provides a remarkably lucid synthesis of diverse ideas about causality based on superb scholarship and is always entertaining. I heartily recommend it. -- David Reuben, MD, David Geffen School of Medicine, University of California, Los Angeles From the two year old child's endlessly nested 'why' questions to the Old Testament and the modern scientist, and through many philosophers in between, Peter Rabins takes us on a fascinating quest in search of answers to that seemingly simplest of all questions: Why? Simple but enigmatic because, like the two year old, how do we know when to be satisfied and how do we know when we know? Throughout The Why of Things, Rabins examines fundamental aspects of how we know-or don't. In his erudite yet accessible book, readers will learn everything from philosophical categorization to nonlinear dynamics in a way that will suddenly make sense, even if they never do find out exactly why. -- Stuart Firestein, Columbia University, author of Ignorance: How It Drives Science if you're looking to learn how to better reason things out through logic and comparative analysis, then this one may be for you. Lifelong Dewey Blog Quite simply, wow. This is one of the most complex, mind-boggling and ultimately satisfying books I have read in a very long time. The Garden Window Blog A most enjoyable read and source of inspiration. The book constitutes a noteworthy addition to Professor Rabins' academic production... Philosophers of science - and perhaps more specifically philosophers interested in causality, explanation, or medicine - would gain a lot in reading it. MetascienceTable of ContentsPreface Introduction 1. Historical Overview: The Four Approaches to Causality 2. The Three-Facet Model: An Overview 3. The Answer Is Either "No" or "Yes": Causality as a Categorical Concept 4. Probabilities 5. A Third Model of Causality: The Emergent 6. Empirical: The Physical Sciences 7. Empirical: The Biological Sciences 8. Empirical: Epidemiology 9. Narrative Truth: The Empathic Method 10. Cause in the Ecclesiastic Tradition 11. Seeking the Why of Things: The Model Applied References Index

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Book SynopsisA leading bioethicist explores the intractable threats to our well-being that persist despite the multigenerational effort to defeat them.Trade ReviewThis book is a wide-ranging, sincere, and syncretic attempt to identify and analyze the greatest threats to the planet today. It is a work of tremendous breadth of vision, with an earnest concern about some of the most serious problems of our time. Callahan is a master of clear communication. -- Donna Dickenson, author of Me Medicine vs. We Medicine: Reclaiming Biotechnology for the Common Good Daniel Callahan's powerful, lucid book offers a sober confrontation with some of the most serious problems facing the world today, asking us to change our ideas of progress to mitigate the catastrophic consequences of how we have come to live. -- Michael Roth, Wesleyan University Callahan, a pioneer in bioethics, has written a thoughtful meditation on our most recalcitrant worldly challenges, from the health of our bodies to the wellbeing of our planet. Well-written and accessible, The Five Horsemen of the Modern World demonstrates how the complex mix of technology, politics, and media have slowed progress and calls for a more productive partnership with sustainable businesses to chart a path forward. -- Paul Sabin, author of The Bet: Paul Ehrlich, Julian Simon and Our Gamble Over Earth's Future Callahan is subtle in expressing his point of view-you never feel like he is pushing an ideology or a single-minded solution at the reader. He lets the data speak first, and then he sets the path. -- Sheldon Krimsky, author of Stem Cell Dialogues: A Philosophical and Scientific Inquiry Into Medical Frontiers Callahan's analysis of the evolution of global problems is instructive and accessible; his use of data, clear and persuasive. A work of impressive scope. -- Steve Cohen, Columbia University It is hard enough to write a wise book on a single major social problem, but Daniel Callahan has written a wise book about five of them, ultimately proposing important suggestions for moving forward. The Five Horsemen should be mandatory reading for anyone interested in climate change, food distribution, the water supply, chronic illness or obesity-in other words, all of us. This book challenges us to look at the global and local ramifications of everything we know and do. -- Barron H. Lerner, MD, PhD, Author of The Good Doctor: A Father, A Son and the Evolution of Medical Ethics Pragmatic and measured. Nature Recommended. CHOICETable of ContentsPreface Acknowledgments I. Mapping an Irregular Terrain 1. Our Overheating, Fraying Planet 2. Feeding a Growing Population: How, and with What Kind of Food? 3. Water: Not Everywhere and Not Always Fit to Drink 4. Chronic Illness: Rich or Poor, Few Escape 5. Obesity: The Scourge of Bad Diets and Sedentary Habits II. Examining the Pathways Through the Thickets 6. Always More People and Ever More Elderly: Caring and Paying 7. The Technology Fix: A Way Out? 8. A Volatile Mix: Public Policy, the Media, and Public Opinion 9. Law and Governance: Managing Our Public Planet and Our Private Bodies III. Toward the Future: Progress, Hope, and Fear 10. Progress and Its Errant Children: More Is Never Enough 11. The Necessary Coalition: Social Movements, Legislatures, and Business Notes Index

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Book SynopsisWritten for the educated patient and health care provider, Conquering Lyme Disease gives an up-to-the-minute overview of the science that is transforming the way we address this complex illness. Brian A. Fallon and Jennifer Sotsky argue forcefully that the expanding plague of Lyme and other tick-borne diseases can be confronted successfully.Trade ReviewLyme disease is a more complicated and nuanced illness than has been previously recognized. Fallon and Sotsky's experience with the neuropsychological manifestations of Lyme, combined with their insights into the current patient experience, make this book a significant addition to the literature. A well-organized, comprehensive treatment of Lyme disease and the associated issues that patients face. -- John Aucott, Johns Hopkins University School of Medicine, Lyme Disease Research CenterTable of ContentsAcknowledgmentsPreface Basic Terminology1. What Is Lyme Disease?2. The Early History and Epidemiologic Surveillance3. What Are the Symptoms and Signs of Lyme Disease?4. What Do the Diagnostic Tests Tell Us?5. The Great Divide and the Lyme Wars6. Why Would Symptoms Persist After Antibiotic Treatment?7. What Are the Treatments for Lyme Disease? 8. Other Tick-Borne Infections9. What Other Non-infectious Diseases Cause Lyme-Like Symptoms?10. Lyme Disease Prevention and Transmission11. Suggestions to the Patient Seeking Evaluation or Treatment12. The Experience of the Patient with Chronic Symptoms13. Frequently Asked Questions14. The Good News Emerging from Lyme Disease ResearchGeneric (Brand) Drug NamesGlossary of TermsReferencesIndex

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Book SynopsisWritten for the educated patient and health care provider, Conquering Lyme Disease gives an up-to-the-minute overview of the science that is transforming the way we address this complex illness. Brian A. Fallon and Jennifer Sotsky argue forcefully that the expanding plague of Lyme and other tick-borne diseases can be confronted successfully.Trade ReviewA lucid and important book, filled with moving case histories and vignettes, about an infectious illness that is threatening many lives. -- Siddhartha Mukherjee, author of The Emperor of All Maladies: A Biography of Cancer and The Gene: An Intimate History Lyme disease is a more complicated and nuanced illness than has been previously recognized. Fallon and Sotsky’s experience with the neuropsychological manifestations of Lyme, combined with their insights into the current patient experience, make this book a significant addition to the literature. A well-organized, comprehensive treatment of Lyme disease and the associated issues that patients face. -- John Aucott, director, Johns Hopkins Lyme Disease Clinical Research CenterConquering Lyme Disease is a balanced and factual synthesis of what is known and unknown about Lyme disease. Written in a clear and understandable way for a lay audience as well as medical professionals, it is a rich source of information on this complex subject, explaining the science behind current treatments and future directions for research. -- Stephen W. Barthold, University of California, DavisAn enlightening, informative, and up-to-date account of the key issues surrounding the complexity, controversy, prevention, diagnosis and treatment of Lyme borreliosis, especially the persistent form of the disease. Written by an outstanding and well-respected physician with tremendous experience, Conquering Lyme Disease will help to bridge the great divide and offer new hope in our fight against this debilitating disease. A must read for all interested in Lyme and associated diseases. -- Ying Zhang, MD, Johns Hopkins University, Bloomberg School of Public HealthA sturdy reference on an illness whose varied presentations can bedevil patients and caregivers alike. * Publishers Weekly *In Conquering Lyme Disease, colleagues and coauthors Fallon and Sotsky push readers to grapple with some underlying scientific principles. Readers will have a better sense of where the research is today, where treatment falls short, and what the future may hold. * Library Journal *What is science’s role in turning the corner on what some have labelled a 'public health failure'? Physicians Brian Fallon and Jennifer Sotsky tackle this question in their insightful study Conquering Lyme Disease, in which they journey beyond the history, biology and symptoms of the illness. Their greatest accomplishment, by far, is delivering multiple viewpoints with minimal bias and great sensitivity: the clinician’s, the researcher’s and, particularly, the patient’s. -- James G. Logan * Nature *Highly suggested to everyone. -- Anna Maria Polidori * Articles and more... *By presenting an accessible, measured examination of the disease and synthesizing current research, the authors offer readers a great service...Highly recommended. * Choice *Fallon and colleagues have produced a valuable book combining humanistic Forster-type narratives and scientific Fisher-like elements to examine the human condition of chronic illness while describing current research in the complexities of Lyme disease. -- Paul Auwaerter * The Lancet Infectious Diseases *A timely new book. * CMRubinWorld *Table of ContentsAcknowledgmentsPreface Basic Terminology1. What Is Lyme Disease?2. The Early History and Epidemiologic Surveillance3. What Are the Symptoms and Signs of Lyme Disease?4. What Do the Diagnostic Tests Tell Us?5. The Great Divide and the Lyme Wars6. Why Would Symptoms Persist After Antibiotic Treatment?7. What Are the Treatments for Lyme Disease? 8. Other Tick-Borne Infections9. What Other Non-infectious Diseases Cause Lyme-Like Symptoms?10. Lyme Disease Prevention and Transmission11. Suggestions to the Patient Seeking Evaluation or Treatment12. The Experience of the Patient with Chronic Symptoms13. Frequently Asked Questions14. The Good News Emerging from Lyme Disease ResearchGeneric (Brand) Drug NamesGlossary of TermsReferencesIndex

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