Medicine / Healthcare: general issues / topics Books

Book SynopsisThis reference presents cutting-edge basic and clinical research on all forms of interferon (IFN) involvement in the management of multiple sclerosis (MS)-detailing topics from IFN-receptor molecular interactions to synergy and interference with other agents such as cytotoxic drugs and chemotherapy. Features detailed research findings on IFN ß -1a (Avonex) and IFN -1b (Betaseron).Trade Review"…an excellent reference for anyone interested in the basic mechanisms of action of the interferons and the clinical chapters provide a clear account of their role in the current management of patients with multiple sclerosis."-The Canadian Journal of Neurological Sciences, 1998Table of ContentsThe Molecular Biology of Interferon-ß from Receptor Binding to Transmembrane Signaling, Lawrence M. Pfeffer and Stefan N. ConstantinescuThe Molecular Biology of Type I Interferons (Interferon- /ß) (Gene Activation, Promoters, Proteins Induced), Thomas DeckerPharmacokinetics of Interferon-ß and the Biological Markers It Induces, Patricia L. WittInterferons and the Central Nervous System Glia, Timothy VartanianEffects of Interferon on the Central Nervous System, Nachum Dafny, Bertha Prieto-Gomez, and Cruz Reyes-VazquezNeuropsychological Effects of Interferon Therapy, Neil H. Pliskin, Anthony T. Reder, and Diane S. GoldsteinThe Effects of Interferon-ß on Cytokines and Immune Responses, Peter RieckmannThe Pathogenetic Role of Interferon- in Multiple Sclerosis, Gianvito Martino and Luigi M. E. GrimaldiThe Effects of Interferons and Other Cytokines on Experimental Autoimmune Encephalomyelitis, Hubertine Heremans and Alfons BilliauEffects of Oral Administration of Type I Interferons on Experimental Autoimmune Encephalomyelitis, Staley A. BrodInterferon- in the Treatment of Multiple Sclerosis, Lorne F. Kastrukoff and Joel J.-F. OgerRecombinant Interferon- in the Treatment of Multiple Sclerosis: Effects on Exacerbation Rate, Magnetic Resonance Imaging of Lesion Activity, and Cytokines, Luca DurelliInteferon ß-1a Treatment of Multiple Sclerosis, Robert M. HerndonInteferon ß-1b (Betaseron) Treatment of Multiple Sclerosis, Robert L. KnoblerEffects of Inteferon ß-1b on Multiple Sclerosis Lesions Evaluated by Magnetic Resonance Imaging and Other Magnetic Resonance Techniques, Robert A. Koopmans, David K. B. Li, Guo Jun Zhao, Elana Brief, Alex MacKay, Irene Vavasour, Ken Whittall, and Donald W. PatyAdverse Effects of Interferons, Richard Cirelli, Kathleen B. Herne, Monica L. McCrary, and Stephen K. TyringInterferon-t: A Potential Treatment for Inflammatory Central Nervous System Disease, Jeanne M. Soos, Joel Schiffenbauer, Howard M. Johnson, and Carol H. PontzerClinical Trials of Multiple Sclerosis, Jeremy C. Hobart and Alan J. ThompsonThe Incidence and Clinical Significance of Antibodies to Interferon-a, Kjell Öberg and Rachel M. McKennaQuantitation and Characterization of Multiple Sclerosis Patient Antibodies to Interferon-ß, Eirik Nestaas, James G. Files, Jeffrey W. Nelson, and Erno Pungor, Jr.

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Book SynopsisSynthesizing disparate information into a readily accessible format, this insightful volume presents state-of-the-art reviews on the basic and clinical features of pulmonary diseases in HIV-infected individuals-informing critical decision making as well as suggesting avenues for future research. A beneficial compendium for those dealing with pulmonary complications of HIV infection, Human Immunodeficiency Virus and the Lungsurveys current knowledge on the epidemiology of HIV infection examines HIV''s effects on lung cells in addition to immune functions within the lung details individual pulmonary infections in terms of etiology, clinical presentation, diagnosis, treatment, and prophylaxis emphasizes the indications and limitations of various diagnostic techniques, including invasive and noninvasive testing and screening considers noninfectious pulmonary complications from neoplastic and inflammatory to immunological disorTable of ContentsOverview of HIV Infection Overview of Respiratory Disease in HIV Infection, Mark J. RosenHIV Infection in Europe: An Overview of Epidemiology and Pulmonary Complications, Court Pedersen, Thomas L. Benfield, and Jens D. LundgrenHIV and Injecting Drug Users, Don C. Des Jarlais and Samuel R. FriedmanIntensive Care for Patients with HIV Infection, Vera A. De PaloEffects of HIV on the Lung HIV Biology and Infection of Lung Cells, Elizabeth A. RichHIV and Lung Lymphocyte Function, Carlo Agostini and Gianpietro SemenzatoHIV and Alveolar Macrophage Function, Homer L. Twigg IIIDiagnosis of Pulmonary Disorders Bronchoscopic and Other Invasive Sampling Techniques in the Diagnosis of Pulmonary Complications of HIV Infection, Steve H. SalzmanNoninvasive Diagnostic Tests, Roslyn F. SchneiderPulmonary Illness in HIV-Infected Adults: Screening and Case Finding, Roslyn F. Schneider and Paul A. KvalePulmonary Infections Bacterial Pneumonia in the Setting of Human Immunodeficiency Virus Infection, Robert E. Hirschtick and Jeffrey GlassrothPneumocystis carinii Pneumonia, John D. StansellHIV and Tuberculosis, Bonita T. Mangura and Lee B. ReichmanViral Infections of the Lung in HIV Infection, Jeanne Marie WallaceFungal Pneumonias Complicating HIV Infection, Scott F. Davies and George A. SarosiPulmonary Toxoplasmosis, Frank L. AcerraPulmonary Cryptosporidiosis, Emanuel I. WurmStrongyloidiasis, Juan Carlos CeledónNoninfectious Pulmonary Disorders Neoplastic Diseases, Dorothy A. WhiteInflammatory Disorders: Spectrum, Pathogenesis, and Pathology, William D. TravisLymphocytic Interstitial Pneumonitis, Deborah M. Ushkow and Roslyn F. SchneiderNonspecific Interstitial Pneumonitis, Frederick P. OgnibenePrimary Pulmonary Hypertension and HIV Infection, Jeffrey I. KuritzkyInfection ControlInfection Control for the Pulmonary Specialist, Beth G. Raucher

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Book SynopsisFocusing on how increased understanding of brain function affects clinical neuroscience, this title explores the interface between neuroscience advances and clinical neuroscience advances by examining the hypotheses that drive this evolution. It reviews the relevant underpinnings of neurosurgical techniques, treatments, and conceptual approaches.Table of ContentsNeuroscience Hypotheses and Translation into Neurosurgery Practice. Clinical Prospects for Neural Grafting Therapy for Cortical Lesions. Spinal Cord and Peripheral Nerve Regeneration. Cellular Brain Ischemia and Stroke: Neuroprotection, Metabolism and New Strategies for Brain Recovery. Imaging and Functional Mapping of Local Circuits and Epilepsy. Pre-ictal Seizure Detection and Demand Epilepsy Treatment Strategies. Neuroprosthetics and Clinical Realization of Brain-Machine Interfaces. Novel Treatments in Movement Disorders. Advanced in Therapy for High Grade Gliomas. Spinal Dysraphism: The Search for Magic. elayed Cerebral Vasospasm: Hypotheses and Advances. Endovascular Treatment Advances. Neuroscience ICU Therapeutics and Diagnostics.New Directions and Therapeutics in Spine Treatment. Clinical Research in Surgery. Neurosurgery Teaching Techniques.

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Book SynopsisProvides Insight into How Cytokine Action Impacts the Physiology and Pathology of the CNS. As with the first edition of Cytokines and the CNS, this completely updated and revised edition introduces neurobiologists to cytokine biology and immunologists to the unique functions of cytokines in CNS physiology. The dramatically accelerating interest in cytokines and cytokine/chemokine signaling over the past several years has encouraged an explosion of literature on cytokines. The similarity between factors involved in inflammation or immunity, and those implicated in neural development, physiology, and repair has become so apparent that familiarity with cytokines must now be considered an essential element in the neurobiologist's cognitive tool-kit. Conversely, for immunobiologists, the concepts elaborated by neurobiologists to understand developmental patterning and networked organ function continue to evolve in such a way that comprehension of cytokine action in the CNS Table of ContentsThe CNS: Cells, Tissues and Reactions to Insult. Cytokines – Wherefrom and Whereto. Cytokine Receptors. Cytokines and Signaling. Inflammatory Complexities in the CNS: New Insights into the Effects of Intracellular Redox State and Viral Infection in Modulating the Biology of Oligodendrocytes and Their Precursor Cells. Cytokines and Development of the Nervous System. Cytokines and CNS Inflammation. Cytokines and Immune Regulation in the Nervous System. Cytokines and Neurodegeneration. Cytokine Expression and Signaling in Brain Tumors. Cytokines and Defense Pathology of the CNS. Cytokines and Multiple Sclerosis. Cytokines in Brain Trauma and Spinal Cord Injury. Cytokine-Based Therapeutics for Intrinsic CNS Disease Processes.

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Book SynopsisLaboratory automation is an increasingly important part of the job description of many laboratory scientists. Although many laboratory scientists understand the methods and principles involved in automation, most lack the necessary engineering and programming skills needed to successfully automate or interface equipment in the lab. A step-by-step, how-to reference and guide, Practical Pharmaceutical Laboratory Automation explores the processes needed to automate the majority of tasks required in research today. The author discusses topics ranging from automated mathematical analysis to robotic automation of chemical processes, to combinations of these and other processes. He presents a detailed discussion of high throughput screening and assay development and takes an in-depth look at Visual Basic as the primary programming language used in laboratories. The text has a dedicated web site (http://www.pharmalabauto.com) that contains all the sample code and examples contained witTable of ContentsIntroduction. Microsoft Excel Visual Basic Macros Running VBA Macros in Excel. Advanced Microsoft Excel VB Macro Techniques. Robotic Automation Using Visual Basic. Low Level Hardware Interfacing Using VB. Electronics for Automation. Robust Data Analysis Using Origin Lab's Origin. Agilent (HP) Chemstation Macro Writing. Appendices.

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Book SynopsisThe ballooning body of research devoted to hyaluronan (HA) reflects its enormous potential for various medical applications. There have been many successes of varying degrees in the development of medical products based on HA, but also some setbacks. While there is obviously ample information available on the chemistry and various properties of this macromolecule, Practical Aspects of Hyaluronan Based Medical Products is the first book devoted to systematically applying this knowledge to product development.Based on the author''s extensive experience working with HA, this book explores in detail the chemistry, composition, formulation, testing, safety, effectiveness, quality control, and regulatory approval of HA medical products. It begins with a survey of the historical development and recent products based on hyaluronan. Subsequent chapters detail the rheological properties of the molecule and explore the chemical principles and methods forming the technical basis of productTable of ContentsOverview. Chemistry. Rheological Properties of Hyaluronan as Related to Its Structure, Size, and Concentration. Standards, Tests, and Analytical Methods. Safety of Hyaluronan-Based Medical Products in Their Indicated Applications. Clinical Performance, Mechanism of Action, and Product Characteristics. Index.

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Book SynopsisThis authoritative volume contains 179 chapters by international experts on recent developments in our understanding of amyloid proteins, protein folding disorders, and new and proposed clinical trials in amyloidosis. Topics include detection and characterization techniques; biological functions; genetics; disorders, diagnosis, and treatments, including organ transplants and drug therapies; results from extensive clinical studies; and epidemiology. This is a valuable resource for clinicians who care for patients with systemic and localized forms of amyloidosis, and for researchers in biochemistry, neurobiology, and cell biology.Table of ContentsAmyloid Fibrillogenesis: AL Amyloidosis. AA Amyloidosis. Familial Amyloidosis. Central Nervous System Amyloidosis. Localized Amyloidosis. Therapeutics. Satellite Symposium, Neurochem Inc.

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Book SynopsisContinuing the tradition set by the first and second editions, each a bestseller in its own right, the third edition of Immunotoxicology and Immunopharmacology provides reviews of environmental agents, updated to reflect the latest information on how these agents influence immune system function and health. For the first time in the book's history, an entire section covers the phylogeny and ontogeny of the immune system, spanning levels of biological complexity from earthworms to marine mammals.Table of ContentsImmunotoxicology and Hazard Identification. Immunopharmacology and Immunotoxicology of Therapeutics. Environmental Agents. Immunotoxicology in the Lung. Developmental Immunotoxicity. Wildlife Immunotoxicology. Autoimmunity and Autoimmune Diseases. Neuroimmunology. Allergy and Hypersensitivity.

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Book SynopsisThis comprehensive publication draws together the important aspects of carcinogen-cell interaction. This interesting work describes the regulation of normal cell proliferation, cellular responses to carcinogen damage, the biologic consequences of cellular DNA modification, the structural and genomic changes resulting from carcinogen insult, and the possible involvement of such changes in the conversion of normal human fibroblasts to malignant cells. It presents current reviews with up-to-date literature references and provides critical information from leading investigators that is essential in understanding the biology of human cell transformation. This volume is especially useful to advanced students in genetic toxicology, molecular biologists, and all who are interested in the molecular and macromolecular changes in human cells leading to neoplasia.Table of ContentsPreface. Variations in Susceptibility to Initiation of Carcinogenesis During the Cell Cycle. Cell Cycle Regulation of DNA Repair Enzymes and Pathways. DNA Repair and Poly(ADP-ribose) Synthesis in Human Fibroblasts and Other Cell Types. Repair of O-Alkylation Damage in Human Cells. Ultraviolet Radiation-Induced Transformation of Human Cells. Biological Characterization and Quantitation of Markers of Transformation of Human Fibroblasts. Mechanisms for Cell Transformation and Carcinogenesis by Genotoxic and Nongenotoxic Agents: Role of Sodium Saccharin. Relationship Between Bulky Carcinogen-DNA Modification: Carcinogenesis and Mutagenesis. Metabolism of Polyaromatic Hydrocarbons by Human Fibroblasts. DNA Adducts and Human Cell Transformation. Cytotoxicity and Cell Culture. Mechanisms by Which Phorbol Ester Tumor Promoters Affect Gene Expression in Human Cells. Changes in Gene Expression Associated with Neoplastic Transformation of Human Fibroblasts: The Abundant Cellular Proteins. Differential Repair of Damage in Specific DNA Sequences of Human Cells. Index.

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Book SynopsisInnovative Leukemia and Lymphoma Therapy provides a complete and up-to-date overview of the exciting new treatment modalities in leukemia and lymphoma that are being introduced in the clinic today. Written by international experts in the field, this volume examines clinical studies on topics such as: tyrosine kinase inhibitors, histon deacetylase inhibitors, and farnesyl transferase inhibitors radioimmunotherapy, gene-directed therapy, and immunotherapy by vaccination monoclonal antibodies anti-angiogenesis approaches Within each chapter, this well-illustrated, comprehensive source provides a summary of the rationale for treatment, the pathways that are involved, and the translational research to students, scientists, and clinicians. In addition, this book focuses on the concerns of conventional but novel anticancer agents, modulation of classical multidrug resistance, and modulators of single agent drug r

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Book SynopsisThe objective of this book is to review and summarize recent developments in our understanding of iron transport and storage in living systems. It includes an overview of the evolutionary aspects of iron metabolism and bacterial iron transport, as well as a detailed discussion of molecules with specific roles in iron metabolism in higher organisms. It also presents relationships between intracellular iron metabolism and cell proliferation. Iron Transport and Storage addresses the comparative aspects of iron transport and storage in different tissues. This essential volume is very useful for hematologists, physical and biological chemists, cell and molecular biologists, physiologists, and clinicians with an interest in the biology and metabolism of iron.Table of ContentsIRON IN BIOORGANIC EVOLUTION. An Introduction to the Nature of Iron Transport and Storage. Iron-Dependent Enzymes in Mammalian Systems. Parallels in the Mode of Regulation of Iron Assimilation in All Living Species. Iron and Oxygen: A Dangerous Mixture. STRUCTURE OF PROTEINS OF IRON STORAGE AND TRANSPORT. Transferrin and Lactoferrin. Ferritin. MOLECULAR BIOLOGY OF PROTEINS OF IRON TRANSPORT AND STORAGE. Molecular Biology of the Transferrins. Molecular Analysis of the Transferrin Receptor and Its Gene. Ferritin Gene Structure and Expression. ROLE OF IRON AND PROTEINS OF IRON METABOLISM IN CELL PROLIFERATION AND MALIGNANCY. Iron-Transferrin Requirements and Transferrin Receptor Expression in Proliferating Cells. Ribonucleotide Reductase. Ferritin in Malignant Cells. IRON METABOLISM IN SPECIFIC TISSUES. Comparative Aspects of Iron Transport and Storage in Different Tissues. Developmental Changes in Iron Storage (the Ferritins) and Iron Transport (the Transferrins and Transferrin Receptors). Intestinal Iron Metabolism and Absorption. Erythroid Cell Iron Metabolism and Heme Synthesis. Iron Metabolism in the Reticuloendothelial System. Modulation of the Availability of Intracellular Iron. Iron and Proteins of Iron Metabolism in the Central Nervous System.

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Book SynopsisThis book represents a comprehensive update on pulmonary surfactant by merging classical knowledge with new information. Topics include surfactant secretion and alveolar processing and recycling; physical bases and different theoretical models of the physiological mechanism for pulmonary surfactant action; recent findings on surfactant-like material in other organs; developmental processes and multifactorial regulation; etiology and physiopathology of neonatal respiratory distress; and modern methods for functional explorations of the lung in neonates and experimental models in animals. The book also contains a discussion on the management of hyaline membrane disease, from both the experimental and clinical points of view.Table of ContentsChapter 1 Pulmonary Surfactant — An Overview, Chapter 2 The Type II Pneumocyte, Chapter 3 Nature, Function, and Biosynthesis of Surfactant Lipids, Chapter 4 Structure, Function, and Regulation of Pulmonary Surfactant Proteins, Chapter 5 The Biology of the Surfactant-Associated Proteins, Chapter 6 Comparative Aspects of Pulmonary Surfactant, Chapter 7 Secretion, Alveolar Processing, and Turnover of Pulmonary Surfactant, Chapter 8 Physiological Mechanisms for the Action of Pulmonary Surfactant, Chapter 9 Role of Surfactant in Other Organs, Chapter 10 Developmental Aspects of the Alveolar Epithelium and the Pulmonary Surfactant System, Chapter 11 Fibroblast Pneumonocyte Factor, Chapter 12 Etiology of Neonatal Respiratory Distress Syndrome and the Assessment of Lung Maturity, Chapter 13 Functional Exploration of the Lung in Neonatal Respiratory Distress Syndrome. Use of Animal Models for the Study of Respiratory Distress, Chapter 14 Exogenous Surfactant in the Management of Hyaline Membrane Disease, Index

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Book SynopsisWith molecular imaging becoming one the fastest growing topics in medical schools, Informa Healthcare presents Molecular Imaging in Oncology, the first comprehensive reference on molecular imaging in oncology.Giving clinicians and researchers a greater understanding of the current field, this text covers: instrumentation and techniques cancer imaging probe design molecular genetic imaging cellular processes clinical translation Filled with over 500 images, of which more than 50 are in color, illustrating diagnostic and therapeutic capabilities of molecular imaging in cancer, this text outlines all procedures for radiologists, radiology physicists, and radiation oncologists in a cTable of ContentsForeword. A Word on Molecular Imaging. Preface. Tumor Biology. Introduction to Molecular Biology. Methods in Molecular Biology. The Analysis of Complex Datasets: Challenges and Opportunities. Molecular PET Imaging Instrumentation and Techniques. Molecular SPECT Imaging Instrumentation and Techniques. Ultrasound Instrumentation and Techniques. Oncological Applications of MR Spectroscopy. Physiological and Functional Imaging with CT: Techniques and Applications. Multi-Modality Imaging Instrumentation and Techniques. Targeted Agents for MRI. High-throughput Screening for Probe Development. Radiopharmaceuticals for SPECT. Radionuclides for Therapy. CEST Contrast Agents. Optical Imaging Probes. Nanoparticles in Molecular Imaging. Long-lived and Unconventional PET Radionuclides. The Design of New Imaging Agents Using Positron Emitting Radionuclides as the Reporter. Targeted Radiolabeled Receptor-avid Peptides. Targeted Ultrasound Contrast Agents. Quantification in Small Animal PET and SPECT Imaging. In Vivo Imaging Mouse Models of Breast Cancer. Basics of Small Animal Handling for In Vivo Imaging. Imaging Cellular Networks and Protein-Protein Interactions In Vivo. Novel Reporter Probes for HSV1-tk Gene Expression. Clinical Potential of Gene Expression Imaging. Overview of Molecular-genetic Imaging. Imaging Angiogenesis. Imaging Apoptosis. Imaging Cell Trafficking with MR Imaging. General Considerations for Labeling and Imaging of Cells. Molecular Imaging of the Extracellular Matrix and Lymphatic Phenomena in Tumors. Nuclear Imaging of Adoptive Cell Therapies. Optical Techniques for Imaging of Cell Trafficking. Radioimmunotherapy of Cancer. Monoclonal Antibody Imaging. Advanced MRI Imaging in Cancer: Translating Basic Science to Practice. Molecular Imaging of Breast Carcinoma. FDG PET/CT Imaging. Clinical uses and opportunities. Molecular Imaging of Prostate Cancer. Anticancer Drug Development with Optical Imaging. Drug Development with Radiopharmaceutica

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Book SynopsisThe only available reference to comprehensively discuss the common and unusual types of rickettsiosis in over twenty years, this book will offer the reader a full review on the bacteriology, transmission, and pathophysiology of these conditions. Written from experts in the field from Europe, USA, Africa, and Asia, specialists analyze specific pathogens at the epidemiological, microbiological, and molecular levels, and discuss the latest advancements in the diagnosis, management, and treatment of rickettsial diseases.Table of ContentsRICKETTSIA AND HUMAN RICKETTSIOSES. Bacteriology, Taxonomy and Phylogeny of Rickettsia. Physiopathology, Pathology and Immunity. Arthropods and Rickettsia. Animals and Rickettsia. Murine Typhus. Louse-Borne Epidemic Typhus. Rickettsialpox. Flea-Borne Spotted Fever. Tick-Borne Rickettsioses. Rocky Mountain Spotted Fever. African Tick-Bite Fever. Mediterranean Spotted Fever. Other Tick-Borne Rickettsioses. Rickettsias of Unknown Pathogenicity. ANAPLASMATACEAE AND HUMAN ANAPLASMOSIS AND EHRLICHIOSES. Bacteriology and Phylogeny of Anaplasmataceae. Vectors and Reservoir Hosts. Ehrlichioses in Human Beings. Anaplasmosis in Human Being. ORIENTIA TSUTSUGAMUSHI AND SCRUB TYPHUS. Orientia Tsutsuganushi and Scrub Typhus. COXIELLA BURNETII AND Q FEVER. Bacteriology. Pathophysiology of Q Fever. Epidemiology. Clinical Aspects, Diagnosis and Treatment. WOLBACHIA AND HELMINTIC DISEASES IN HUMAN BEINGS. Wolbachia and Helmintic Diseases in Human Beings. GENOMICS OF RICKETTSIAL AGENTS. Genomics of Rickettsial Agents. DIAGNOSTIC STRATEGY OF RICKETTSIAL DISEASES. Diagnostic Strategy of Rickettsial Diseases. ANTIMICROBIAL SUCEPTIBILITY OF RICKETTSIAL AGENTS. Antimicrobial Susceptibility of Rickettsial Agents

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Book SynopsisFocusing on a public health problem affecting millions of people of all ages, the second edition of Concussive Brain Trauma: Neurobehavioral Impairment and Maladaptation reflects Dr. Rolland S. Parker''s more than 25 years of neuropsychological practice and research in traumatic brain injury and stress, and his prior experience as a clinical psychologist. Unique in its coverage of the personality changes, family dysfunction, and stress that often occur in the wake of concussive brain trauma, this book uses case examples to illustrate persistent and acute alterations of consciousness, as well as cognitive, mood, personality, and social effects of head injury in order to guide appropriate treatment. With six additional chapters, this edition covers: Post-concussive syndrome, biomechanical causes of trauma, and acute and chronic phases of co-morbid brain and somatic injTable of ContentsConcussion: Not Always "Minor" Head Injury. Introduction to the Postconcussion Syndrome. The Central Nervous System: Organization of Behavior. Acute Alterations of Consciousness. The Internal Milieu: Brain and Body. Biomechanics and Tissue Injuries. Acute Brain and Somatic Injury. The Acute Stress Response. Chronic Posttraumatic Stress: Injury, Disease, and Burnou. Comorbid Posttraumatic Stress Disorder and Concussion. Disorders of Sensation, Motion, and Body Schema. Vocal Motor Disorders. Chronic Pain and Posttraumatic Headaches. Chronic Posttraumatic Disorders of Consciousness. Cognition, Language, and Intelligence. Posttraumatic Personality Disorders . Children’s Brain Trauma. Outcome and Treatment: Concussive Trauma

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Book SynopsisAs our population continues to grow, more and more patients are becoming dependent on long-term ventilatory support. Therefore, the need for quality options such as home mechanical ventilation is fast becoming a necessity. Ventilatory Support For Chronic Respiratory Failure (CRF) is the first resource to authoritatively address the needs of the acute or chronic respiratory patient through the transition from the hospital to the home-care setting. This reference covers best practices in the management of CRF patients who are: clinically stable ventilator dependent in an institutional setting transitioning back to the community likely to require home-based care Covering ethical and economic management issues, as well as perspectives from renowned national and international specialists, this guide:Table of ContentsPreface. Foreword. Chronic Respiratory Failure. Principles of Positive Pressure Mechanical Ventilatory Support. Chronic Respiratory Failure As A Global Issue. The difficult to wean patient in the ICU setting. Causes of difficult weaning: Which mechanisms are associated with long-term ventilator dependence? Size of the Problem, What Constitutes Prolonged Mechanical Ventilation, Natural History, Epidemiology. Weaning protocols - including NIV. Weaning Units - The U.S. Perspective. Weaning in a Specialized Facility. Rehabilitation in the intensive care unit. Organization Of Rehabilitaiton In The ICU. Indications and Physiological Basis of Rehabilitation in the ICU. Peripheral and respiratory muscle training. Innovative Approaches in Muscle Training: Transcutaneous Electrical Muscle Stimulation. Psychological Aspects and Interventions in Patients with Chronic Respiratory Failure. Chronic Ventilatory Assistance In the hospital (non ICU). Definition and indications. Clinical Settings For Ventilator-Assisted Individuals - When And Why - LTAC-SNF-CAVC. The Multidisciplinary Team-Training and Experience. Clinical Experience in CAVC Unit. Long term mechanical ventilation in the community. Indications, Definitions, Guidelines and Outcomes in Restriction and Obstruction. Choice of Devices, Ventilators, Interfaces and Monitors. Training the Home Health Team. Sending the Ventilated Patient Home. Health-related Quality of Life. Mechanical Ventilation-Legal and Ethical Issues. Special Considerations. Pharmacological Treatment for Patients with Chronic Respiratory Failure. Patient-Ventilator Interfaces for Invasive and Noninvasive Ventilation. Tracheostomy Weaning from Longer Term Ventilation. Communication Alternatives. Diaphragmatic Pacing in Chronic Respiratory Failure. Secretion Management. The Importance of Overnight Monitoring in the Management of Chronic Respiratory Failure. Management of Respiratory Infections. Nutrition in the ICU. Skin Integrity, Bowel and Bladder Care.

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Book SynopsisOsteoporosis, a growing epidemic among women in North America, Europe, and Japan, is a painful, costly disease that has presented a treatment challenge to healthcare professionals. Until recently, therapies have focused on agents that slow bone resorption, and have had only limited success at increasing bone mass.However, exciting new developments are on the verge of changing the treatment of this debilitating disorder. Two anabolic agents, the parathyroid hormone (PTH) and the fluoride ion, show tremendous promise as tools for building and retaining bone - with no adverse side effects. Anabolic Treatments for Osteoporosis is a comprehensive account of the latest studies that have been carried out on these two agents, and a thorough assessment of their prospects as osteoporosis therapeutics. This unique book combines basic science and up-to-date clinical data to present a complete picture of this breakthrough in the treatment of a globally significant health issue.Table of ContentsOsteoporoses: Their Nature and Therapeutic Targets. Osteoporosis - Mechanisms and Models. PTH: Skeletal Effects in the Ovariectomized Rat Model for Postmenopausal Bone Loss. Parathyroid Hormone: The Clinical Experience and Prospects. Adenylyl Cyclase-Activating Anabolic Agents: Parathyroid Hormone and Prostaglandins E. Bone Formation May Be Uncoupled from Resorption, as Demonstrated by a New Class of hPTHrP-(1-34) Analogues in Both Rapid and Slow Turnover Models of Osteopenia. Commercial Exploitation of Parathyroid Hormone Therapy for the Treatment of Postmenopausal Osteoporosis. The Insulin-Like Growth Factors: Potential Anabolic Agents for the Skeleton. Osteogenic Actions of Fluoride: Its Therapeutic Use for Established Osteoporosis. Index. NTI/Sales Copy

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Book SynopsisMammalian Neuroendocrinology presents a concise examination of how the nervous and endocrine systems interact to regulate physiological processes. Selected experimental results are presented to illustrate the current understanding of neuroendocrine processes. Neural influences and endocrine feedback mechanisms related to the secretion of adenohypophysial hormones are summarized for each hormone. The book's concise nature and readable style are highly suited for use as a graduate textbook.There are also chapters devoted to each of the following topics: neurohypophysis, pineal gland, adrenal medulla, hormones and behavior, and neuroendocrine immunology. Comparisons are made among species of mammals, including laboratory rodents, domesticated ungulates, and primates. Agricultural and/or clinical aspects relevant to these topics are covered when appropriate. Mammalian Neuroendocrinology is excellent for students and professionals in neuroendocrinology, neuroscience, endocrinology, rTable of ContentsChapter 1. Principles of Neuroendocrinology, Chapter 2. Neuroendocrine Morphology, Chapter 3. Neurohypophysis, Chapter 4. Neural Controi of Adenohypophysis, Chapter 5. Miscellaneous Neuropeptides, Chapter 6. Corticotropin and Melanotropin, Chapter 7. Thyrotropin, Chapter 8. Somatotropin, Chapter 9. Prolactin, Chapter 10. Pineal Gland, Chapter 11. Gonadotropins in the Male, Chapter 12. Gonadotropins in the Female, Chapter 13. Adrenal Medulla, Chapter 14. Hormones and Behavior, Chapter 15. Neuroendocrine Immunology, Index

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Book SynopsisLung cancer is the leading cause of cancer death in the United States, but IGRT (image guided radiation therapy) offers the possibility of more aggressive and enhanced treatments. The only available source on the subject that emphasizes new imaging techniques, and provides step-by-step treatment guidelines for lung cancer, this source helps clinicians locate and target tumors with enhanced speed, improve the accuracy of radiation delivery, and correctly target cancerous masses while avoiding surrounding structures.Edited by radiation oncology experts from the renowned M.D. Anderson Cancer Center, this guide: focuses on novel approaches using IGRT, particularly PET/CT, SPECT, 4-D CT, stereotactic body radiation therapy, IMRT and proton radiotherapy, and offers expert guidance on the dose, fractionation, target volume delineation (including recommended margins with and without respiratory gating based on our new 4-D CT study), and normal tissue tolerTrade Review"This is the best IGRT lung cancer book available. I would recommend it without reservation to any of my colleagues." —Nate Bittner, MD (University of Washington Medical Center), Doody’s Reviews Table of ContentsRadiotherapy Guidelines and Techniques for Nsclc. Introduction. Stage Based Radiotherapy Guidelines. Radiotherapy Guidelines in Small Cell Lung Cancer. Introduction. Stages Based Radiotherapy Guidelines. Image-Guided Staging, Treatment Planning and Clinical Outcome Prediction/ Evaluation Using PET/CT, SPECT. Imaging Based Lung Cancer Staging. Where to Target and Where to Spare: Incorporation of Pet/Ct and SPECT Imaging Into Treatment Planning. Who Will Recur and Who Will Suffer From Complication: Evaluation and Prediction Based On Imagines. Tumor Motion Consideration: 4-D Ct Based Radiotherapy Planning and Delivery. How Much Lung Cancer Moves Based On 4-D Ct Study. What Is Individualized Optimal Treatment Planning and Delivery, What Is The Optimal Margins. On-Board Imaging Evaluation. Implanted Fiducials and Respiratory Gated Radiotherapy. Indication and Limitation. Reduced Margin Using Implanted Fiducials and On-Board Imaging. Stereotactic Body Radiation Therapy (Sbrt) In Stage I, Selective Stage Ii and Isolated Peripheral Recurrent Nsclc. Radiobiology. Indications and Contra-Indications. Dose and Fractionation Regiments. Image-Guided Sbrt Planning and Delivery. Normal Tissue Tolerance. Clinical Outcome: Local Control, Survival and Toxicity. IMRT In Selective Locally Advanced Nsclc. Indications and Contraindications. Optimizing IMRT Planning In Lung Cancer, IMRT Quality Control. Clinical Outcome. Image-Guided Proton Radiotherapy. What Is Proton Beam. Image-Guided Proton Beam Treatment Planning. Image-Guided Dose Escalation/Acceleration Of Proton Radiotherapy In Stage I Nsclc. Image-Guided Concurrent Chemotherapy and Dose Escalated Proton Therapy In Stage Iii Nsclc. Pre-Clinical and Clinical Outcome. Future Development: Deformable Registration to Track Tumor Motion and 4-D Radiotherapy Planning and Verification. What Is Deformable Registration, How To Track Tumor Motion. 4-D Radiotherapy Planning Based On Tumor Motion. Future Development of 4-D Delivery. Future Development: 4-D Ct Based Lung Ventilation Study: Potential Role In Radiotherapy Planning.

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Book SynopsisAssembling, reviewing, and synthesizing state-of-the-art information on translational research and therapies of melanoma into one convenient source, Melanoma: Translational Research and Emerging Therapies provides clinicians and researchers the necessary context and perspective to intergrate and effectively deploy cutting-edge therapies into daily practice.This source: synthesizes the scientific principles, clinical trial results, and clinical implications of emerging and translational melanoma therapies covers the entire range of translational research and therapies, including pathogenesis, progression pathways, immunotherapy, gene therapy, adjuvant therapy, surgical staging, and metastatic disease provides context and perspective to enable the clinician to select and use new therapies effectively and knowledgeably Table of Contents1. UV radiation in melanoma development and pathogenesis. 2. Overview of molecular pathways in melanoma. 3. CHALLENGING MELANOCYTIC NEOPLASMS:SPITZOID MELANOMA VERSUS SPITZ NEVUS. 4. Melanoma genomics: Techniques and implications for therapy. 5. Ras signaling in melanoma development and prevention. 6. Targeting BRAF activity as a novel paradigm for melanoma therapy. 7. Therapeutic targeting of the melanoma stem cell population. 8. Pigmentation pathways and Microphtalmia-Associated Transcription Factor as new targets in melanoma. 9. Understanding interferon: Translating biologic advances into clinical progress. 10. Interferon and autoimmunity. 11. New approaches for optimizing melanoma vaccines. 12. Adoptive T cell immunotherapy. 13. Procurement of human melanoma specimens for translational research: Practical and legal considerations. Glossary of clinical and scientific terms.

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Book SynopsisAs the third leading cause of death in the United States, stroke accounts for one in every fifteen deaths and is the major cause of disability in the country. Compiled by a renowned editorial team, this reference bridges the gap between basic science and patient care protocols, and collects 43 expertly written chapters that range from laboratory-based research on animal models to the progression, mechanisms, treatment, and prognosis of diseases such as subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), focal ischemic stroke, and global cerebral ischemia.Trade Review"…The guiding philosophy of the present volume, assembled under the wise editorship of Drs. Bhardwaj, Alkayed, Kirsch, and Traystman, is to emphasize translationally important topic areas in cerebrovascular disease, where advances at the bench lead to advances at the bedside….Taken together, the contributors to this timely volume offer the reader a rich menu to savor. Clinician-investigators will benefit from its breadth and depth."-Myron D. Ginsberg, M.D., University of Miami Miller School of Medicine, Florida, U.S.A. (from the foreword)Table of ContentsSUBARACHNOID HEMORRHAGE (SAH). Animal Models of Subarachnoid Hemorrhage. Pathogenesis of Cerebral Aneurysmal Growth and Rupture. Pathogenesis of Cerebral Vasospasm. Surgical Management of Aneurysmal Subarachnoic Hemorrhage. Endovascular Management of a Patient After SAH. Intra-operative Management of Aneurysmal SAH. Medical Management of Subarachnoid Hemorrhage. Clinical Trials in SAH. Prognosis and Outcomes Following Aneurysmal Subarachnoid Hemorrhage. INTRACEREBRAL HEMORRHAGE (ICH). Animal Models of Intracerebral Hemorrhage. Pathophysiologic Mechanisms of Brain Injury Following Intracerebral. Surgical Management of an Intracerebral Hemorrhage. Medical Management of Intracerebral Hemorrhage. Clinical Trials in Intracerebral Hemorrhage. Prognosis and Outcomes Following Intracerebral Hemorrhage. FOCAL ISCHEMIC STROKE. Animal Models of Ischemic Stroke. Pathogenesis of Brain Injury Following Ischemic Stroke. Neuroimaging in Ischemic Stroke. Thrombolytic Therapy for Acute Ischemic Stroke. Medical Management of Acute Ischemic Stroke. Clinical Neuroprotectve Trials in Ischemic Stroke. Prognosis and Outcomes Following Ischemic Stroke. Venous Strokes and Venous Sinus Thrombosis. GLOBAL CEREBRAL ISCHEMIA. Animal Models of Global Cerebral Ischemia. Pathogenic Mechanisms of Brain Injury Following Global Cerebral Ischemia. Management of Brain Injury Following Cardiopulmonary Arrest. Prognosis and Neurologic Outcomes Following Cardiopulmonary Arrest. DOGMAS, CONTROVERSIES AND FUTURE DIRECTIONS. Failure of Neuroprotective Agents to Show Benefit in Clinical Trials. Ischemic Preconditioning. Therapeutic Potential of Hypothermia in Acute Stroke. Decompressive Hemicraniectomy for Stroke: An Old Therapy Revisited. Blood-Pressure Management in Subarachnoid Hemorrhage, Acute Ischemic Stroke, and Intracerebral Hemorrhage. Diagnosis and Treatment of Cerebral Arteriovenous Malformations (AVM). Endovascular Therapy for Carotid Stenosis. Acute Stroke Care Units: A Critical Appraisal. Telemedicine Applied to Stroke Care. Multimodality Neuromonitoring in Acute Stroke. Gender Differences in Stroke Pathobiology: Therapeutic Implications. Ultrasonography in the Management of Acute Stroke. Acute Stroke in the Young. Functional Recovery After Stroke with Cell-based Therapy. Brain Attack

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Book SynopsisThe changing role of managed care can be a daunting challenge to both experienced clinicians and students entering into the practice for the first time. Managed care seems to have come out of nowhere and has affected the psychotherapy community so strongly that private-practice clinicians are finding that they must reinvent their practices in order to work well with managed care systems.The Textbook of Behavioral Managed Care presents, in a well organized and comprehensive manner, the basic definitions of managed care; its effects on clinicians; and most importantly, how clinicians can respond to the pressures of managed care and still maintain the quality of their practices. For experienced clinicians, the information in this volume will prove invaluable in adapting to the ever increasing role of managed care; for the student entering into practice, the book is an essential tool for understanding the forces that managed care has brought into play.The better managed carTable of ContentsIntroduction: Clinician's Guide: Using The Book As A Practice Management System. The Rise of Third Party Payors: Functional and Systemic Impacts. The Defining Concepts of Managed Care: Set I. The Defining Concepts of Managed Care: Set II. Preauthorization to Intake. Assessment to Diagnosis. Goal Setting. Treatment. Reauthorization, Treatment, and Post Termination.

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Book SynopsisGynaecological cancers represent the second most common group of cancers and the most common cause of cancer death in woman, but the needs of women with gynaecological cancer are frequently unrecognised and often neglected. A diagnosis of gynaecological cancer can threaten a woman's body image, fertility, sexuality, femininity, relationships, and various roles in life. Nurses and other health professionals who care for women with gynaecological cancer require a resource that covers a range of issues in depth and breadth if they are to provide comprehensive care. This book offers a rich resource of material - presented in a stimulating style. It provides expert, practical, person-centred, evidence-based advice for nurses and other health professionals who care for women with gynaecological cancer.

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Book SynopsisGreenfield's is the worldâs leading neuropathology reference. It provides a comprehensive account of the pathological findings in neurological disease, their biological basis, and their clinical manifestations. The two-volume work provides a remarkable text which is clear, comprehensive and precise with exceptional illustrations. This is a tried and tested reference for scientists, clinicians, researchers and students who wish to learn more about neurological disease.Volume One is available as a single purchase as well as within the set, and it covers General Pathology of the Nervous System, Cerebrovascular Disorders, Developmental Neuropathology and Metabolic Disorders, Epilepsy, Neuroinflammatory Disorders and Neurodegenerative Disorders.The tenth edition features fully updated sections throughout. Global coverage from an international team of editors and contributors. Fully downloadable and easily useable e-version included.Table of ContentsVolume One. Section 1: General Pathology of the Nervous System. Diseases of brain synapses and neuronal architecture. Astrocyte functions in health and disease. Oligodendrocytes. Microglia. Ependymal cells and choroid plexus. Cellular inclusions and artefacts. Basic Pathophysiology. Section 2: Cerebrovascular Disorders.Vascular disease, hypoxia and consequences. Section 3: Developmental Neuropathology and Metabolic Disorders. Normal development of the nervous system. Acquired disorders of childhood. Malformations. Metabolic and degenerative disorders of childhood. Lysosomal disorders. Peroxisomal disorders,Mitochondrial disorders. Section 4: Epilepsy.Epilepsy pathology. Section 5: Neuroinflammatory Disorders Multiple sclerosis and other demyelinating conditions. Other immune-related disorders affecting the nervous system.Section 6: Neurodegenerative disorders.Neurodegenerative diseases: classification. Pathogenesis and concepts. Movement disorders. Degenerative ataxic disorders. Motor neuron disorders. Cognitive decline. Neurodegenerative proteinopathies: PrP proteinopathies. Neurodegenerative proteinopathies: Alzheimer’s disease (A-beta and Tau proteinopathy). Neurodegenerative proteinopathies: Synuclein proteinopathies. Neurodegenerative proteinopathies:Tau proteinopathies. Neurodegenerative proteinopathies: TDP-43 proteinopathies. Neurodegenerative proteinopathies: FUS/FET proteinopathies. Neurodegenerative proteinopathies: Trinucleotide repeat disorders. Miscellaneous proteinopathies and neurodegenerative conditions. Ageing-related pathologies of the brain. Mixed pathologies of the ageing and neurodegenerating brain.Diagnostic approach to the neuropathology of neurodegenerative diseases.

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Book SynopsisThis text details the techniques and procedures now needed in gynecology, with a special focus on reconstructive vaginal, hysteroscopic, laparoscopic, robotic, and laparotomic surgery, including that designed to preserve or enhance fertility. Residents, clinicians, and surgeons can now understand pathogenesis, appropriate imaging and investigation, and application of surgical and nonsurgical strategies and techniques for such common problems as fibroids and endometriosis. The two volumes of this second edition contain over 20 new chapters and over 140 instructional videos; each chapter features Key Point summaries.Table of ContentsEditors Contributors Introduction VOLUME 1: FUNDAMENTALS AND CONDITIONS1. Anatomy and surgical dissection of the female pelvis: For the gynecologic surgeonAndrew I. Brill, Robert M. Rogers, Jr., and Victor Gomel2. Reproductive physiology for the gynecological surgeonVictor Gomel, Malcolm G. Munro, and Peter F. McComb3. Energy-based surgical devicesAndrew I. Brill and Malcolm G. Munro4. Principles of laparoscopic surgerySukhbir S. Singh, Olga Bougie, and Malcolm G. Munro5. Principles of microprocessor-assisted laparoscopic ("robotic") surgeryErica Dun, Vadim Morozov, and Ceana Nezhat6. Principles of laparotomic and vaginal surgeryVictor Gomel and Malcolm G. Munro7. Principles of hysteroscopic surgeryBarry H. Sanders and Malcolm G. Munro8. Imaging for the gynecologic surgeonCaterina Exacoustos and Margit Dueholm9. Preservation of fertility in gynecologic surgery: Strategies and techniquesVictor Gomel, Mohamed A. Bedaiwy, and Recai Pabuççu10. Complications of surgery of the female reproductive tractNyia Noel, Christina Alicia Salazar, Keith Isaacson, and Malcolm G. Munro11. Congenital anomalies of the female reproductive tractJoseph S. Sanfilippo and Kathryn D. Peticca12. Ectopic pregnancyVictor Gomel and Malcolm G. Munro13. Endometrial polypsMarit Lieng and Jason A. Abbott14. Adenomyosis: Uterus-sparing treatmentGrigoris F. Grimbizis and Themistoklis Mikos15. Endometriosis: General principlesSukhbir S. Singh, Catherine Allaire, and David L. Olive16. Uterine leiomyomasLevent Mutlu, Kimberly W. Keefe, and Hugh S. Taylor17. Pathogenesis of pelvic floor disordersGeoffrey W. Cundiff18. Pelvic infections and their sequelaeJorma Paavonen19. Fallopian tube disordersVictor Gomel20. Postoperative adhesionsVictor Gomel and Philippe R. Koninckx21. Pathogenesis, pathology, and clinical significance of intrauterine adhesionsMiriam M.F. Hanstede, Mark Hans Emanuel, and Jason A. Abbott22. MalignancyDenis Querleu23. Chronic pelvic painFred M. Howard and Malcolm G. Munro24. Abnormal uterine bleedingMalcolm G. Munro25. The adnexal massDenis Querleu26. Diagnosis, investigation, and nonsurgical management of pelvic organ prolapse and urinary incontinenceYaël Levy-Zauberman and Hervé Fernandez27. Infertility: Mechanisms and investigationVictor Gomel28. Recurrent pregnancy loss: A new strategy for evaluation based on genetic testingWilliam H. Kutteh, Carolyn R. Jaslow, Paul R. Brezina, Raymond W. Ke, Amelia P. Bailey, and Mary D. StephensonVOLUME TWO: GYNECOLOGICAL SURGERY29. Surgery for congenital anomalies: Hysteroscopic, laparoscopic, laparotomic, and vaginalJoseph S. Sanfilippo, Kathryn D. Peticca, and Fabiola Balmir30. Surgery for vulvar disordersHoward T. Sharp31. Endometrial sampling and uterine curettageYaël Levy-Zauberman, Perrine Capmas, and Hervé Fernandez32. Management of endometrial polypsJason A. Abbott and Marit Lieng33. Endometrial ablationMalcolm G. Munro34. Surgery for intrauterine adhesionsMark Hans Emanuel and Miriam M.F. Hanstede35. Leiomyomas I: Hysteroscopic and other transvaginal approachesBarry H. Sanders and Malcolm G. Munro36. Leiomyomas II: Abdominal approachesWilliam H. Parker, Tommaso Falcone, and Malcolm G. Munro37. Leiomyomas III: Image-guided surgery and proceduresScott Chudnoff, Sukrant Mehta, and Eleanor Hawkins38. HysterectomyJon Ivar Einarsson and Mobolaji O. Ajao39. Reconstructive surgery of the fallopian tubeVictor Gomel40. Ectopic pregnancy: Surgical managementVictor Gomel41. Ovarian surgeryVictor Gomel and Mohamed A. Bedaiwy42. Endometriosis I: Surgery for endometriosis associated with painNicola Berlanda and Paolo P. Vercellini43. Endometriosis II: Surgical treatment of endometriosis associated with infertilityDavid L. Olive and Mauro Busaca44. Endometriosis III: Deep infiltrating endometriosisSukhbir S. Singh and Sugandha Agarwal45. Procedures specific for chronic pelvic painFred M. Howard46. Surgical treatment of urinary incontinenceYaël Levy-Zauberman, Xavier Deffieux, and Hervé Fernandez47. Management of pelvic organ prolapseGeoffrey W. Cundiff48. Surgery during intrauterine pregnancyMichel Canis, Nicolas Bourdel, Céline Houlle, Benoit Rabischong, Revaz Botchorishvili, and Jean L. Pouly49. Preservation of fertility in malignancyDenis Querleu, Sophie Deutsch-Bringer, and Alejandra Martínez50. Oocyte and embryo cryopreservation for fertility preservationAna Cobo and José RemohiIndex

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Book SynopsisThe Manual of Venous and Lymphatic Diseases constitutes a concise but comprehensive and contemporary description of the nature and management of venous and lymphatic diseases. This innovative book instructs the post-graduate trainee in phlebology and is also valuable to undergraduate students wishing to gain a broader knowledge than is available in general surgical texts. Addtionally, it is a useful reference for practising phelebologists, vascular surgeons and imaging specialists. The text covers basic principles, diagnosis and treatment of chronic venous disease, venous thrombo-embolism, lymphoedema and vascular malformations.Table of ContentsBasic. Embryology.Anatomy Physiology, Chronic venous disease. Pathology.Clinical features and investigation. Management and outcome. Support management. Sclerotherapy. Endovenous thermal ablation.Venous adhesive closure. Surgery for varicose veins.Chronic deep venous disease.Hepato-portal venous diseases.Other chronic venous disorders. Venous thromboembolism.Pathogenesis.Superficial thrombophlebitis.Deep vein thrombosis.Pulmonary and paradoxical embolism. Investigation. Prevention and treatment. Lymphatic disorders. Lymphoedema. Vascular malformations

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Book SynopsisThe most common abnormal growth of the female reproductive system, fibroids, are thought to affect the majority of women at some point during their reproductive years. This text from leading fibroid experts looks at the latest evidence on how the problem impinges on reproduction and the most up-to-date management and treatment options available to help patients with fibroids hoping to conceive.Print versions of this book also include access to the eBook version with links to procedural videos.Table of Contents1. Fibroids and Reproduction: A Bird’s-Eye View. 2. Fibroids and Assisted Reproduction Technology. 3. Fibroids and Endometrial Receptivity/Embryo Implantation. 4. Uterine Fibroids and Recurrent Pregnancy Loss. 5. Fibroids in Pregnancy. 6. Medical Options for Uterine Fibroids in the Context of Reproduction. 7. Fibroid Preoperative Imaging: Ultrasound. 8. Fibroid Preoperative Imaging: Magnetic Resonance Imaging. 9. Interventional Procedures. 10. Hysteroscopic Myomectomy. 11. Laparoscopic and Robotic-Assisted Myomectomy.

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Book SynopsisThis new edition of a groundbreaking book is now in two volumes, on ''Fundamentals, Symptoms, and Conditions on ''Reconstructive and Fertility Preserving Surgery and Procedures. From a distinguished editorial team and internationally recognized contributors the text educates surgeons on the techniques and procedures now needed in gynecology, with a special focus on reconstructive vaginal, hysteroscopic, laparoscopic, and laparotomic surgery, including that designed to preserve or enhance fertility. The reader can now more readily understand pathogenesis, appropriate investigation, and application of both surgical and nonsurgical strategies and techniques. The two volumes contain over 20 new chapters and in the integral ebook, over 140 instructional videos; each chapter has Key Points summarized.

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Book SynopsisThis new edition of a groundbreaking book is now in two volumes, on ''Fundamentals, Symptoms, and Conditions on ''Reconstructive and Fertility Preserving Surgery and Procedures. From a distinguished editorial team and internationally recognized contributors the text educates surgeons on the techniques and procedures now needed in gynecology, with a special focus on reconstructive vaginal, hysteroscopic, laparoscopic, and laparotomic surgery, including that designed to preserve or enhance fertility. The reader can now more readily understand pathogenesis, appropriate investigation, and application of both surgical and nonsurgical strategies and techniques. The two volumes contain over 20 new chapters and in the integral ebook, over 140 instructional videos; each chapter has Key Points summarized.Table of ContentsEditors Contributors Introduction VOLUME 1: FUNDAMENTALS AND CONDITIONS1. Anatomy and surgical dissection of the female pelvis: For the gynecologic surgeonAndrew I. Brill, Robert M. Rogers, Jr., and Victor Gomel2. Reproductive physiology for the gynecological surgeonVictor Gomel, Malcolm G. Munro, and Peter F. McComb3. Energy-based surgical devicesAndrew I. Brill and Malcolm G. Munro4. Principles of laparoscopic surgerySukhbir S. Singh, Olga Bougie, and Malcolm G. Munro5. Principles of microprocessor-assisted laparoscopic ("robotic") surgeryErica Dun, Vadim Morozov, and Ceana Nezhat6. Principles of laparotomic and vaginal surgeryVictor Gomel and Malcolm G. Munro7. Principles of hysteroscopic surgeryBarry H. Sanders and Malcolm G. Munro8. Imaging for the gynecologic surgeonCaterina Exacoustos and Margit Dueholm9. Preservation of fertility in gynecologic surgery: Strategies and techniquesVictor Gomel, Mohamed A. Bedaiwy, and Recai Pabuççu10. Complications of surgery of the female reproductive tractNyia Noel, Christina Alicia Salazar, Keith Isaacson, and Malcolm G. Munro11. Congenital anomalies of the female reproductive tractJoseph S. Sanfilippo and Kathryn D. Peticca12. Ectopic pregnancyVictor Gomel and Malcolm G. Munro13. Endometrial polypsMarit Lieng and Jason A. Abbott14. Adenomyosis: Uterus-sparing treatmentGrigoris F. Grimbizis and Themistoklis Mikos15. Endometriosis: General principlesSukhbir S. Singh, Catherine Allaire, and David L. Olive16. Uterine leiomyomasLevent Mutlu, Kimberly W. Keefe, and Hugh S. Taylor17. Pathogenesis of pelvic floor disordersGeoffrey W. Cundiff18. Pelvic infections and their sequelaeJorma Paavonen19. Fallopian tube disordersVictor Gomel20. Postoperative adhesionsVictor Gomel and Philippe R. Koninckx21. Pathogenesis, pathology, and clinical significance of intrauterine adhesionsMiriam M.F. Hanstede, Mark Hans Emanuel, and Jason A. Abbott22. MalignancyDenis Querleu23. Chronic pelvic painFred M. Howard and Malcolm G. Munro24. Abnormal uterine bleedingMalcolm G. Munro25. The adnexal massDenis Querleu26. Diagnosis, investigation, and nonsurgical management of pelvic organ prolapse and urinary incontinenceYaël Levy-Zauberman and Hervé Fernandez27. Infertility: Mechanisms and investigationVictor Gomel28. Recurrent pregnancy loss: A new strategy for evaluation based on genetic testingWilliam H. Kutteh, Carolyn R. Jaslow, Paul R. Brezina, Raymond W. Ke, Amelia P. Bailey, and Mary D. StephensonVOLUME TWO: GYNECOLOGICAL SURGERY29. Surgery for congenital anomalies: Hysteroscopic, laparoscopic, laparotomic, and vaginalJoseph S. Sanfilippo, Kathryn D. Peticca, and Fabiola Balmir30. Surgery for vulvar disordersHoward T. Sharp31. Endometrial sampling and uterine curettageYaël Levy-Zauberman, Perrine Capmas, and Hervé Fernandez32. Management of endometrial polypsJason A. Abbott and Marit Lieng33. Endometrial ablationMalcolm G. Munro34. Surgery for intrauterine adhesionsMark Hans Emanuel and Miriam M.F. Hanstede35. Leiomyomas I: Hysteroscopic and other transvaginal approachesBarry H. Sanders and Malcolm G. Munro36. Leiomyomas II: Abdominal approachesWilliam H. Parker, Tommaso Falcone, and Malcolm G. Munro37. Leiomyomas III: Image-guided surgery and proceduresScott Chudnoff, Sukrant Mehta, and Eleanor Hawkins38. HysterectomyJon Ivar Einarsson and Mobolaji O. Ajao39. Reconstructive surgery of the fallopian tubeVictor Gomel40. Ectopic pregnancy: Surgical managementVictor Gomel41. Ovarian surgeryVictor Gomel and Mohamed A. Bedaiwy42. Endometriosis I: Surgery for endometriosis associated with painNicola Berlanda and Paolo P. Vercellini43. Endometriosis II: Surgical treatment of endometriosis associated with infertilityDavid L. Olive and Mauro Busaca44. Endometriosis III: Deep infiltrating endometriosisSukhbir S. Singh and Sugandha Agarwal45. Procedures specific for chronic pelvic painFred M. Howard46. Surgical treatment of urinary incontinenceYaël Levy-Zauberman, Xavier Deffieux, and Hervé Fernandez47. Management of pelvic organ prolapseGeoffrey W. Cundiff48. Surgery during intrauterine pregnancyMichel Canis, Nicolas Bourdel, Céline Houlle, Benoit Rabischong, Revaz Botchorishvili, and Jean L. Pouly49. Preservation of fertility in malignancyDenis Querleu, Sophie Deutsch-Bringer, and Alejandra Martínez50. Oocyte and embryo cryopreservation for fertility preservationAna Cobo and José RemohiIndex

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Book SynopsisSonography has emerged as a substantial diagnostic tool today. This handbook aims to cover ultrasound physics, abdominal and obstetric sonography, color Doppler, high resolution sonography and USG guided interventions with multiple choice questions and case reports for practical orientation.Trade Review"This overview is well-suited for those at the beginning of their ultrasound training and for those wish-ing to refresh their basic knowledge."Emily Skelton, research sono-grapher, King’s College London.Table of Contents1) ULTRASOUND PHYSICS. 2) LIVER. 3) GALL BLADDER. 4) BILIARY TREE. 5) SPLEEN. 6) PANCREAS. 7) KIDNEY, URETER AND BLADDER (GENITOURINARY TRACT, GUT). 8) ADRENAL GLANDS. 9) AORTA AND IVC. 10) PELVIC USG (UTERUS AND OVARIES). 11) PROSTATE. 12) PERITONEUM AND RETROPERITONEUM. 13) CHEST. 14) CRITICAL CARE ULTRASOUND-- INCLUDING FAST. 15) ACUTE ABDOMEN AND ABDOMINAL TUBERCULOSIS. 16) INTRODUCTION. 17) FIRST TRIMETER. 18) SECOND TRIMESTER. 19) THIRD TRIMESTER. 20) FETAL MALFORMATIONS. 21) PLACENTA. 22) AMNIOTIC FLUID. 23) UMBILICAL CORD & BIOPHYSICAL PROFILE. 24) GTN (Gestation Trophoblastic Neoplasia). 25) ECTOPIC PREGNANCY. 26) MULTIFETAL PREGNANCY. 27) HYDROPS & INTRA UTERINE FETAL DEATH (IUFD). 28) INCOMPETENT CERVIX. 29) INFERTILITY. 30) Pc PNDT ACT. 31) BASIC TERMINOLOGY. 32) OBSTETRIC DOPPLER. 33) CAROTID DOPPLER. 34) DOPPLER IN PORTAL HYPERTENSION. 35) RENAL DOPPLER. 36) PERIPHERAL VESSEL DOPPLER. 37) HEAD & NECK WITH THYROID. 38) BREAST. 39) ANTERIOR ABDOMINAL WALL. 40) SKIN (CELLULITIS). 41) GASTROINTESTINAL SYSTEM. 42) SCROTUM. 43) MISCELLANEOUS. 44) USG GUIDED INTERVENTIONS. 45) RECENT ADVANCES IN SONOGRAPHY.

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Book SynopsisQuality measures and outcomes are receiving greater attention by the lay and medical communities. The occurrence or mismanagement of complications often results in poor outcomes, increased cost, and significant morbidity. Answering the call for transparency and improvement requires action by all involved in the care of patients. The collection of objective data and quality measures enables the provision of optimal care and desired outcomes while identifying areas for improvement. This text presents the current knowledge of outcomes, as well as the techniques for minimizing and managing complications from the common diseases and procedures within colorectal surgery. Trade Review"This is a well-done publication with clear, well-written chapters and a shortread with high clinical yield. It compares well to other books in the field."Irena Gribovskaja-Rupp, MD (University of Iowa Hospitals and Clinics)Table of ContentsForeword to Improved Outcomes Preface Editors Contributors 1. Preexisting conditions Arida Siripong and Farouq Manji 2. Preoperative bowel preparation Aaron L. Klinger and David A. Margolin 3. Anesthesia and intraoperative positioning W. David Sumrall, III and David E. Beck 4. Sepsis Jennifer S. Beaty and Moriah E. Wright 5. Intraoperative anastomotic challenges David E. Beck 6. Other intraoperative challenges Jesus Flores and Sharon G. Gregorcyk 7. Optimizing use of electronic health records Allison B. McCoy and Genevieve B. Melton-Meaux 8. Postoperative anastomotic complications Traci L. Hedrick 9. General postoperative complications J. Marcus Downs and Kristina K. Booth 10. Care paths and optimal postoperative management Benjamin D. Shogan and Heidi K. Chua 11. Limitations of anorectal physiology testing Thomas E. Cataldo and Syed G. Husain 12. Limitations of colorectal imaging studies Andrew C. Matthews and Charles C. Matthews 13. Transanal endoscopy Aaron L. Klinger and Brian R. Kann 14. Laparoscopy for colorectal disease Bradley R. Davis and Kevin R. Kasten 15. Medical legal issues Terry C. Hicks and David E. Beck 16. Miscellaneous conditions Alexander T. Hawkins and M. Benjamin Hopkins 17. Outcomes and quality Shaun R. Brown and Kurt G. Davis 18. Hemorrhoidal surgery Jeffery Mino and Massarat Zutshi 19. Nonoperative therapy for hemorrhoidal disease Joseph C. Adongay and Scott A. Brill 20. Surgery and nonoperative therapy of perirectal abscess and anal fistulas Mohammed Iyoob Mohammed Ilyas and Craig A. Reickert 21. Surgery and nonoperative therapy of anal fissure Mary T. O’Donnell and Cary B. Aarons 22. Surgery for pilonidal disease and hidradenitis suppurativa John D. Hunter and Leander M. Grimm Jr. 23. Surgical treatment of fecal incontinence Nicole M. Saur and Joshua I.S. Bleier 24. Surgery for rectal prolapse Steven R. Hunt 25. Management of diverticulitis David E. Beck, H. David Vargas, and Molly M. Ford 26. Abdominal surgery for colorectal cancer Jason F. Hall and Rocco Ricciardi 27. Abdominal restorative surgery for rectal cancer Charles C. Vining and Nijjia N. Mahmoud 28. Transanal approaches to rectal cancer Charles B. Whitlow and Lara McKean Basté 29. Abdominoperineal resection W. Brian Perry and Huisar Dao Campi 30. Management of rectal cancer after complete clinical response to neoadjuvant chemoradiotherapy Rodrigo O. Perez and Laura Melina Fernandez 31. Indications and outcomes for treatment of recurrent rectal cancer and colorectal liver/lung metastases Luanne M. Force and David J. Maron 32. Evaluation and management of peritoneal metastatic disease James Fleshman and Katerina O. Wells 33. Chemotherapy for colon and rectal cancer Jonathan Lu and Marc R. Matrana 34. Adjunctive treatment of rectal cancer with radiation and the adverse effects of radiation exposure of the rectum Roland Hawkins 35. Surgical management of ulcerative colitis Shannon McChesney and Brian R. Kann 36. Surgery for Crohn disease Emily Steinhagen and Sharon L. Stein 37. Evaluation and management of lower gastrointestinal bleeding Arjun N. Jeganathan and Skandan Shanmugan 38. Ostomies Danielle Pickham and Supriya S. Patel 39. Operative and nonoperative therapy for chronic constipation Robert J. Sinnott, Michelle C. Julien, and Daniel E. Sarmiento 40. Colorectal trauma Alison Althans and Scott R. Steele 41. Prevention and management of urologic complications after colorectal surgery Jacob A. McCoy, J. Christian Winters, and Scott E. Delacroix Jr.Index

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Book SynopsisComprehensive book on mitral stenosis not only compiles the existing published knowledge and literature about mitral stenosis in a succinct manner but also has input from experts having years of experience in this field. It will serve as an authentic reference and a ready reckoner for cardiology fellows, practicing cardiologists, academics and researchersTable of ContentsForeword Preface Glossary Contributors PART 1. PATHOPHYSIOLOGY AND CLINICAL FEATURES 1. The history of mitral stenosis Balram Bhargava and Neeraj Parakh2. Epidemiology and the natural history of mitral stenosis Anita Saxena3. The etiology of mitral stenosis Anunay Gupta and Sandeep Singh4. The pathophysiology of mitral stenosis Sudheer Arava, Kusuma Harisha, and Ruma Ray5. Clinical features of mitral stenosis Jaganmohan A. Tharakan6. Complications of mitral stenosis Senguttuvan Nagendra Boopathy and Ambuj RoyPART 2. INVESTIGATIONS 7. Electrocardiogram, chest radiograph, and ancillary investigations Arun Sharma, Kanika Bhambri, Gurpreet S. Gulati, and Neeraj Parakh8. Echocardiogram Vivek Chaturvedi9. Cardiac catheterization Raghgav Bansal and Ganesan KarthikeyanPART 3. MANAGEMENT 10. Assessment of severity and treatment strategy Ravi S. Math11. Medical management Rajnish Juneja and Neeraj Parakh12. Percutaneous transvenous mitral commissurotomy: Techniques and hardware Neeraj Parakh and Ravi S. Math13. Challenges in percutaneous transvenous mitral commissurotomy Ravi S. Math and Cholenahally Nanjappa Manjunath14. Surgical treatment Shiv Kumar Choudhary and Amol BhojePART 4. SPECIAL SITUATIONS 15. Juvenile mitral stenosis Arima Nigam and Ravi S. Math16. Pregnancy and mitral stenosis Raghav Bansal, Preeti Yadav, and Sivasubramanian Ramakrishnan17. Lutembacher syndrome Kikkeri Hemannasetty Srinivas and Anand Subramaniam18. Atrial fibrillation and other arrhythmias Neeraj Parakh and Vivek Chaturvedi19. Congenital mitral stenosis Danny Manglani and Saurabh Kumar Gupta20. Degenerative mitral stenosis Neeraj Parakh21. Mitral bioprosthetic valve dysfunction Neeraj ParakhPART 5. MISCELLANEOUS 22. Pulmonary hypertension in mitral stenosis Ravi S. Math23. Left-ventricular dysfunction in mitral stenosis Ravi S. Math24. Subvalvular deformity in mitral stenosis Vivek ChaturvediIndex

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