Medicine / Healthcare: general issues / topics Books

Book SynopsisAn approachable, scientific look at the development of Covid-19 over the course of 2020. This book takes a unique look at a truly unique year.Trade Review‘A tour-de-force from the brilliant mind of Dr Justin Stebbing’ -- David Sinclair, Harvard professor and author of Lifespan‘An extraordinary piece of research, tense, exciting, a vivid account of the most important and thrilling story of our time. It’s an exemplar of humanity at its worst but, thank the lord, scientific collaboration at its best.’ -- Sir Michael Parkinson CBE‘No one can have followed the Covid-19 pandemic more closely than Justin Stebbing, who absorbs scientific research the way the rest of us inhale air. His diary of the plague year is a gripping illustration of how scientific knowledge is really acquired.' -- Niall Ferguson, Milbank Family Senior Fellow, the Hoover Institution, Stanford‘A startling and thought-provoking journey into the greatest health emergency of our time.’ -- Baroness Joanna Shields, CEO of BenevolentAI‘Justin’s ability to go deep on the science AND to connect the dots at an incredible speed gives him a unique viewpoint. Our frequent discussions on SARS-CoV-2 were always insightful. His daily updates were part of my daily routine to keep learning about the virus and Covid-19 disease.’ -- Stéphane Bancel, CEO of Moderna

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Book SynopsisThe Complete Guide to Nutrition in Primary Care Edited by Darwin Deen, MD, MS Lisa Hark, PhD, RD Clinicians and patients agree that primary care office visits should include routine nutrition assessment and counseling. But how do you fit it into an already crowded consultation? And what is the most up-to-date advice? With The Complete Guide to Nutrition in Primary Care, Drs. Deen and Hark provide the necessary tools. This comprehensive overview of nutrition answers your questions on: Nutrition as Preventive Medicine Nutrition through the Lifecycle Improving Health by Changing Diet and Lifestyle Behaviors Vitamins, Minerals, Dietary Supplements, and the Alternative Successful Changes to the Environment This timely paperback contains everything the primary care clinician needs to counsel patients on diet and lifestyle issues. Keep it close at hand for the frequent consultation it is sure to receive. DrTrade Review“This work is intended for practicing primary physicians, nurses, and those going into these fields. It is meant as a general overview for those who need to include a routine nutrition assessment into their patients' visits. It would be a welcome addition in health care collections.” (American Reference Books Annual, Vol. 39 (2008)) "Due for release in July, this guide arms health professionals and consumers with nutritional information for preventing obesity-related diseases. Essential for expanding knowledge and research into preventative medicine." (Optimum Nutrition, Summer 2007) “The authors note…the unique contributions that registered dietitians can make in the…prevention and management of chronic disease.” (Doodys Review)Table of ContentsEditors vii Contributors viii Preface xi Section 1 Nutrition as preventive medicine 1 Nutrition and the primary care clinician 3Darwin Deen and Katherine Margo 2 Changing the office culture to make it work 15Arlo Kahn and Jane White 3 Methods of weight control 31Cathy Nonas, Jennifer Williams, and Valentine J Burroughs Section 2 Nutrition through the life-cycle 4 Growing up healthy 57Susan Konek and Diane Barsky 5 Feeding the mother-to-be 85James M Nicholson, Catherine Sullivan and Morghan B Holt 6 Staying healthy in later life 109Connie Watkins Bales and Heidi K White Section 3 Improving health by changing diet and lifestyle behaviors 7 Dyslipidemia, hypertension and metabolic syndrome 135Frances Burke and Philippe Szapary 8 Diabetes, pre-diabetes and hypoglycemia 161Marion J Franz and Richard Wender 9 Gastrointestinal disorders 179Marianne Aloupis and Thomas Faust 10 Everything else 201Marion Vetter and Katherine Chauncey Section 4 Vitamins, minerals, supplements and alternative nutrition 11 Vitamins 223Randee Silverman and Jeremy Brauer 12 Minerals 249Randee Silverman and Jeremy Brauer 13 Dietary and nutritional supplements 275Joel S Edman and Elizabeth Horvitz 14 Considering the alternatives 293Benjamin Kligler, Joel S Edman and Mary Beth Augustine Section 5 Successful changes to the environment 15 It’s all about changing behaviors 311Darwin Deen and Alice Fornari 16 Community counts 327Kathryn M Kolasa 17 Cultural considerations 341Kim M Gans and Charles B Eaton Appendices 365 Review questions 385 Review answers 428 Index 435

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Book SynopsisUltra Medicine: Essential Preparation for Medical Finals provides a one-stop resource for senior medical students preparing for their final exams. The book is divided into four parts. Part 1 contains a random selection of questions, mimicking actual exam questions covering clinical medicine. The assessment includes 120 multiple choice questions (MCQs) and a further 24 extended matching questions (EMQs) for written exam preparation. Detailed, fully explanatory answers are provided in Part 2, making this text a really useful learning resource. This enables you to check and refresh your understanding and is perfect to help you identify the weaker aspects of your knowledge. Part 3 reflects upon the history and examination routines and is neatly divided into the various body systems. The final part contains 50 objective structured clinical examinations (OSCEs) for clinical assessment and provides the best hints and tips for House Officer skills.<Trade Review"Regardless of the structure of your exams, this is a useful tool especially when mock exams or past papers are in short supply." Sharp, St George's Medical School Gazette, May 2005Table of ContentsContents. Preface. Normal values. Part 1 Practice Papers. Paper 1 Questions. Paper 2 Questions. Paper 3 Questions. Paper 4 Questions. Part 2 Answers. Paper 1 Answers. Paper 2 Answers. Paper 3 Answers. Paper 4 Answers. Part 3 History and Examination Routines. Cardiovascular System. Respiratory System. The Chest Radiograph Routine. Gastrointestinal System. Neurological System. Dermatological System. Part 4 OSCEs. Introduction. OSCEs. House Officer Skills for the OSCE. Index

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Book SynopsisPromises to remodel the way cardiovascular medicine is practised * Written and edited by two pioneers in this area * Specially selected material for the practising clinician * Must-have reference to this developing field to ensure up-to-date patient care .Trade Review"An excellent guide for developing, reviewing, or updating a keen understanding of genetics and its future in medicine. The book should find wide readership." Doodys ReviewTable of ContentsContributors. Foreword. Introduction. 1 The gene in the twenty-first century. Choong-Chin Liew, Victor J. Dzau. Part I: Cardiovascular single gene disorders. 2 Monogenic hypercholesterolemia. Ruth McPherson. 3 Hypertrophic cardiomyopathy. Ali J. Marian. 4 Dilated cardiomyopathy and other cardiomyopathies. Mitra Esfandiarei, Robert Yanagawa, Bruce M. McManus. 5 The long QT syndrome. Sabina Kupershmidt, Kamilla Kelemen, Tadashi Nakajima. Part II: Cardiovascular polygenic disorders. 6 Atherosclerosis. Päivi Pajukanta, Kiat Tsong Tan, Choong-Chin Liew. 7 Heart failure. Markus Meyer, Peter VanBuren. 8 The implications of genes on the pathogenesis, diagnosis and therapeutics of hypertension. Kiat Tsong Tan, Choong-Chin Liew. Part III: Therapies and applications. 9 Gene therapy for cardiovascular disease: inserting new genes, regulating the expression of native genes, and correcting genetic defects. Ion S. Jovin, Frank J. Giordano. 10 Stem cell therapy for cardiovascular disease. Emerson C. Perin, Guilherme V. Silva. 11 Pharmacogenetics and personalized medicine. Julie A. Johnson, Issam Zineh. 12 The potential of blood-based gene profiling for disease assessment. Steve Mohr, Choong-Chin Liew. Index. Colour plates

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Book SynopsisFollowing the GMC's call for greater social and behavioural science input into undergraduate medical education, this brand new title in the Lecture Notes series provides an understanding of how education, social class, family, economics and occupational circumstances, as well as cultural and ethnic influences, shape patients and health professionals alike. A deeper appreciation and understanding of these issues can have a positive effect on clinical diagnosis and practice. Emphasising clinical relevance at all times, the book features photographs and line drawings to illustrate key points, and case studies that provide real-life illustrations of the points discussed. It also contains ''points of view'' boxes which encourage critical thinking and challenge the reader to come up with their own explanations for the phenomena described. Lecture Notes: The Social Basis of Medicine provides information and materials useful not only for undergraduate medical studTrade Review"This book is written in an easy to understand style and contains case studies to illustrate the points made In the text. This helps make it accessible and allows the reader to dip into Individual of sections and chapters of the book for quick reference." (AfPP, June 2009) "The Social Basis of Medicine is a user-friendly, engaging introduction to a topic that even the most hardened surgeon-to-be would appreciate." (Times Higher Education, February 2010)Table of ContentsPreface. Acknowledgements. 1 The social basis of medicine. 2 Beliefs about health, ill health and the body. 3 Health and health care in the popular sector. 4 Health and health care in the professional sector. 5 Health and health care in the folk sector: complementary and alternative medicine. 6 The consultation. 7 Health inequalities. 8 Sex and gender, race and ethnicity in health and health care. 9 Mental health, illness and health care. 10 Disability and society. 11 Promoting health. 12 Chronic illness. 13 Death and dying. 14 International health. Glossary

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Book SynopsisThis is a vital text to help you with the competency assessment in the UK Foundation Programme giving practical advice in an easy to follow format.Table of ContentsPart 1 Clinical and Communication skills . 1 Professionalism. 2 The consultation. 3 Health promotion. 4 Clinical reasoning. 5 Communication with colleagues. 6 Medical records. 7 Prioritising time. Part 2 Legal and Ethical Issues in Healthcare . 8 Capacity and consent. 9 The Mental Health Act and common law. 10 Confidentiality. 11 Death certification and the coroner. 12 Fitness to drive. 13 Adult and child protection. 14 Ethical principles in healthcare. 15 Advance directives. 16 End of life issues. 17 NHS complaints procedure. Part 3 Clinical Governance and Patient Safety. 18 Why things go wrong. 19 Human factors. 20 Safe prescribing. 21 Infection control. 22 Use of evidence and guidelines. 23 Audit. Part 4 Teaching and Training. 24 Learning about learning. 25 Teaching large groups. 26 Teaching small groups. 27 Presentations. 28 Teaching a skill. 29 How to give feedback. 30 How doctors are assessed. Index

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Book SynopsisThis concise, easy to understand and learner-friendly book invites the readers to actively particpate in the understanding of medical statistical concepts that are frequently used in health care research and evidence-based practice worldwide. Knowing that the best way to learn statistical concepts is to use them, the authors employ real examples and articles from health science literature, complete with the complexities that real life presents, in an approach that will help bring researchers and clinicians one step closer towards being statistical savvy and better able to critically read research literature and interpret the results. A practical hands-on workbook for individual or group exercises Teaches how to understand statistical methods when reading journals, and how to use them in clinical research Emphasizes the use of statistics in evidence-based research Relevant for anyone needing to use statistics, this workbook is an ideal reTable of ContentsContents. Foreword. By Virginia A. Moyer. Introduction. Overview. UNIT 1 Hypothesis testing and estimation. UNIT 2 Incidence and prevalence rates. UNIT 3 Comparing proportions. UNIT 4 Relative risk and odds ratio. UNIT 5 Clinical trials. UNIT 6 Comparing mean values. UNIT 7 Correlation and regression. UNIT 8 Follow-up studies. UNIT 9 Survival analyses. UNIT 10 Diagnostic and screening statistics. Answers. Glossary. Index

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Book SynopsisNot sure how to interpret the wealth of data in front of you? Do you lack confidence in applying the results of investigations to your clinical decision making? Then this pocket-sized, quick reference guide to data interpretation may be just right for you. The Hands-on Guide to Data Interpretation is the perfect companion for students, doctors, nurses and other health care professionals who need a reference guide on the ward or when preparing for exams. It focuses on the most common investigations and tests encountered in clinical practice, providing concise summaries of how to confidently interpret investigative findings and, most importantly, how to apply this to clinical decision making. The benefits of this book include: An overview of the normal ranges of test results, followed by a consideration of the differential diagnoses suggested by variance from these values Arranged by system to allow quick acTrade ReviewWhether as a medical student or junior doctor, clinical data is ubiquitous within medicine. The quantity of data that we are required to interpret can often make it seem as though we are in a race to the top of Everest – especially when a well-intentioned consultant thrusts an ECG in front of you and asks you to interpret it... There is nothing worse than being unable to interpret findings in an OSCE or whilst on whirlwind ward rounds. Conversely, being able to understand and use knowledge to interpret clinical information can be thoroughly rewarding. “The Hands-on Guide to Data Interpretation” is the perfect companion and tutor for all data interpretation needs. The Hands-on Guide covers all the main laboratory, clinical and radiological tests used by doctors in the investigation and management of patients. The book is systems based and split into 16 chapters which include specific chapters on microbiology, genetics and imaging. Included at the start of the book is a comprehensive collection of reference ranges including those for hormones and tumour markers. There are also conversion tables for different units for those of us who can’t remember how to change pounds into kilograms. The final chapter on patient data provides practical advice for clerking on the wards. This section places emphasis on the holistic care of patients and demonstrates how knowledge can be applied by bringing specialities together. This 247 page handbook is highly visual and well laid out. It is concise but thorough. The authors have kept the student in mind throughout and have employed a variety of techniques to help make the contents digestible and memorable. Such techniques include the use of mnemonics, tables, graphs, flowcharts, diagrams and clinical images. Mnemonics are used broadly throughout each chapter. They include widely used favourites such as GET SMASHED for the causes of Acute Pancreatitis. Arguably they are used a bit too extensively throughout the book. However, they act to support learning rather than standing as the sole method of learning. Despite their extensive use the layout of such mnemonics prevents them from becoming tedious. Tables are frequently used by the authors to summarise information or to compare and contrast key pathologies. An example which I found particular useful was the comparison between Crohn’s disease and Ulcerative Colitis. The table was concise and provided more detail than was taught in lectures. The information was easy to retain and recall. I’m particularly fond of the table’s ability to make me sound pseudo-intelligent on ward rounds! Graphs are used to emphasise information covered in the text. They are well used throughout and include patterns such as flow-volume loops. Flowcharts are use similarly but also provide greater depth to the information in the text and are excellent in displaying quite complex conceptual data. Particularly useful is a detailed flow chart for adrenal steroid synthesis which all endocrinologists seem to have tattooed on their eyelids! Diagrams are clear and well presented. The majority assist information in tables and the text. Such diagrams are utilised well in presenting dermatomes and myotomes in neurology which support textual information that describes distribution and action in more detail. A unique selling point of this book is the helpful tip boxes which might not be found in a standard text. These handy tip boxes are found in every section and highlight salient points. For a pocket-sized book the contents are particularly impressive. The authors always endeavour to explain key pathology and relate these to findings and patterns in data. Where appropriate, important elements of clinical examination are included, such as the cranial nerve examination. Chapters are further completed by severity scores such as the CURB-65 score for community acquired pneumonia and by risk assessment measures such as the Well’s score for the probability of pulmonary emboli. As alluded to earlier, like many others, I often struggle to understand ECGs. This book covers all the key principles of ECGs thoroughly and includes a simple but detailed 10 step guide to interpretation. There are enough examples to emphasise the points covered but perhaps not enough to become adept at pattern recognition. I similarly feel that examples of x-rays are limited. However, key pathological changes are all excellently described and accompanied by examples. It is also arguable that more examples might have hindered the book’s usefulness as a pocket guide. In both incidences this book proves excellent as a revision tool but is not quite as useful when approaching these modalities for the first time. Other modalities are similarly explained in great detail but are lacking in examples. A separate microbiology chapter is a real advantage of this book. The content is simple and understandable. Flowcharts describe gram staining and identification of bacteria whilst tables are used to cover the general sensitivities of bacteria to antibiotics. I was also particularly impressed by a table offering an introduction to oncological chemotherapeutics. The table succinctly classifies agents and states the most common side effects for each. In conclusion “The Hands-on Guide” is very useful as an introductory text to data interpretation. However, the real strength of this book is apparent when the reader has some previous knowledge of the desired system or is using the book for revision. I feel that the book is an unmatched text in this respect and highly recommend it. (Owen Hibberd, 3rd year medical student, UEA) "It provides an excellent reminder of background physiology with clear explanations of how this relates to tests and their clinical application. For those doctors in primary care, it is also a useful tool and will be particularly helpful in interpreting those slightly aberrant results that fall into your inbox." (InnovAit, 2 February 2012) Format: Softbound text consisting of preface, summary of text abbreviations, and 16 chapters, including index. Audience: Students in medicine and health sciences, interns, residents, physicians, nurses, and other medical professionals for which clinical data interpretation is critical to patient care and management. Purpose: This is a pocket-sized reference containing supporting information appropriate to clinical application. The use of investigative resources and input by experts in specific medical disciplines help focus the use of data to support and minimize challenges associated with required clinical decision efforts. Content: The text is divided into 16 chapters addressing clinical data associated with normal ranges (clinical/physiological normals), the cardiovascular system, the respiratory system, gastroenterology, endocrinology, the renal system, neurology, hematology, rheumatology, obstetrics and gynecology, ophthalmology, oncology, microbiology, genetics, imaging, and patient data. Except for the first chapter on normal clinical ranges, all chapters follow the same presentation format. While materials are comprehensive and well structured, references to established sources are only incorporated as adaptations. This textbook is a clinical guide that can be carried during clinical rotations in hospital settings. The textbook is well written, as topic coverage supports differential diagnostic parameters leading to sound conclusions. Usability: All chapters cover topics in a clear and articulate manner, with consistent formatting that supports introductory information with specific subtopics in the chapter. Each chapter is replete with normal ranges; reference data including diagrams, images, charts, tables, physiological ranges; and notes from specialists within the areas covered. As noted above, tabular data are adaptations from sources, but there is no comprehensive bibliographic section provided. The price of the edition is appropriate and well within reach of students, practitioners, and professionals. Highlights: The single strength of this textbook is the amount of important and practical data packed into a small, portable textbook. Text presentations are concise and clearly written, supporting practicality in real-world applications. The final chapter addressing patient data is a welcome enhancement to the diverse medical specialties covered in preceding chapters, allowing for effective charting sorely needed for accurate presentation of data in the clinical arena. Limitations: The material presented is directly aligned with the purpose and intent of the authors. This reviewer finds no limitations associated with the text. However, a listing of additional primary references at the end of each chapter would serve to enhance the quality of the materials presented. Reviewer's Summary: After reviewing the amount of information provided and comparing it to the intent of the authors, I highly recommend the text to those who require a concise and practical reference source in medical practices. While this textbook serves the clinical informational needs of diverse medical audiences, interpretation and action taken in response to clinical data leading to differential diagnosis should be conducted under the guidance of an experienced medical practitioner. The authors and contributors are to be commended on an excellent job in preparing this textbook." (Peter D. Frade PhD, Wayne State University, in The Annals of Pharmacotherapy, April 2011) "I found it a useful reference tool in dealing with all those haematology and biochemistry results that we see in our daily practice. . .Overall, an absoloute must for every GP's bookshelf, but also a pertinent book for medical students." (General Practitioner, 16 September 2011) "This book has been written by a group of junior doctors who chose to address interpretation of the vast amounts of clinical data that clinicians encounter every day. I found it a useful reference tool in dealing with all those haematology and biochemistry results that we see in our daily practice. It is pocket-sized, yet comprehensive. With care of more complicated medical conditions being transferred to the community, this sort of book will be very useful for GPs. Clinical scenarios The book is divided into systems and the approach is logical. What I find most impressive is that the authors have been intelligent in the topics they have included, selecting the most common conditions as well as clinical scenarios doctors tend to struggle with. At the start of each chapter is a summary of the topics covered. It is written in a readable and simplistic style and the format is clear and concise. There is a plethora of tables, diagrams and charts. I particularly liked the flowchart to differentiate between Gram-positive and Gram-negative bacteria, the summary of antibiotics and the tables for interpreting the minefield that LFTs can be. Scattered throughout the book are the various mnemonics that we all learnt at medical school, such as 'GET SMASHED' for the causes of acute pancreatitis. This is just the sort of handbook I wish I had had at medical school and during my clinical training. It is a very succinct synopsis of the common things that clinicians encounter, explaining various clinical examination findings, interpretation of blood results and other investigations, including radiology, ECGs, pleural, ascitic and lumbar puncture fluid. The beauty of this book is that it effectively simplifies the subject matter and gives you an at-a-glance approach to the task in hand. Overall, an absolute must for every GP's bookshelf, but also a pertinent book for medical students. I wait with anticipation for an iPhone app." (Dr Mathukia, a GP principal in Ilford, Essex, for GPonline.com) "What is good about this book? The aim of this book is to provide a quick reference guide to interpreting the wealth of data that we as doctors come across in our daily working lives. It focuses on common investigations and tests, providing summaries of how to interpret the results and apply them in the clinical setting. Divided into 16 short chapters, it encompasses the major medical and surgical specialties and is easy to use with bullet point sections, clear headings and a full index that aids in rapid retrieval of information. A specialist has reviewed each chapter, and the book includes two GP registrars and a foundation year doctor among its authors, making it highly relevant to the junior doctor working in either hospitals or the community. This book is set apart from other texts in its field by an extensive use of clear concise physiological explanations for both diseases and tests in the clinical chapters. This works particularly well in specialties such as neurology and haematology, where the complex is made simple. The section on the neurological examination, for example, includes clear easy-to-access diagrams of dermatomes, reflexes and visual fields, and there is a useful guide for how to approach neurological disorders. While the section on the interpretation of the full blood count and its abnormalities appears rather dry, it is helpful for focused retrieval of information. Good use has been made of tables of blood results, with abnormal results listed alongside the normal together with explanations of their relevance and suggested causes. The liver function, hepatitis B, thyroid function and bone profile tables are excellent, combining large amounts of often complicated data into clear summaries which are invaluable desk or bedside tools. The chapter on genetics, which is a frequently neglected knowledge area, is brief but thorough and serves well as an aide-mémoire for patterns of disease inheritance. It also provides useful templates for genetic diagrams, which could be used to aid explanations during consultations with patients. What is bad about this book? The book can be over-complicated for such a compact reference guide and seems to lose its way at times, including an excessive amount of physiological theory or background detail. This is evident in the discussion of lung volumes and Gram staining. Keen chemists will recognize the Henderson–Hasselbach equation in the respiratory chapter, but this too seems an unnecessary inclusion of theory that adds little for the reader. The cardiology section appears dense and difficult to follow and readers may be advised to turn to a more straightforward guide for reminders on this investigation and its interpretation. Similarly, different cancers are discussed briefly in relevant speciality chapters and a separate oncology chapter tries to cover this vast and complicated subject with lengthy specific cancer staging examples, which readers may prefer to explore in other books. Some diagrams have been included with little accompanying explanation and require further reference to the text, which detracts from the ability of the book to act as a quick reference guide. The ophthalmology section also suffers from having only black and white retinal images. Finally, the book can at times read like revision notes (from where the authors state that they took inspiration) and there is some unnecessary repetition; the anion gap appears in both the respiratory and the renal chapters, for example, and a description of the histological findings in inflammatory bowel disease is repeated within the same chapter. In conclusion, this is a book largely written for the medical student or hospital-based junior doctor, and overall, it is a succinct and thorough reference guide. It provides an excellent reminder of background physiology with clear explanations of how this relates to tests and their clinical application. For those doctors in primary care, it is also a useful tool and will be particularly helpful in interpreting those slightly aberrant results that fall into your inbox." (Dr Alexandra Davidson, GP Registrar and Academic Fellow, University College London, for InnovAiT, June 2011) Table of ContentsPreface. Acknowledgements. Abbreviations. 1. Normal Ranges. 2. Cardiovascular. 3. Respiratory. 4. Gastrointestinal. 5. Endocrinology. 6. Renal. 7. Neurology. 8. Haematology. 9. Rheumatology. 10. Obstetrics & Gynaecology. 11. Ophthalmology. 12. Oncology. 13. Microbiology. 14. Genetics. 15. Imaging. 16. Patient Data.

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Book SynopsisCurrent heart failure therapeutics affects symptoms without appreciably reducing the mortality rate of 50% in five years -- suggesting a failure in treating the underlying mechanism. This book proposes a new mechanism for heart failure; immune mediated cardiac remodelling for cardiac dysfunction.Table of ContentsContributors. Preface. About the Editors. Part I Immune dysfunction leading to. heart disease: induction by. physiological changes. 1 Immunosuppression by ultraviolet light-B. radiation: amediator of cardiac remodeling. Sherma Zibadi (The University of Arizona), Douglas F. Larson (Sarver Heart Center In the School of Medicine) & Ronald. Ross Watson (Sarver Heart Center in the School of Medicine). 2 Immune mechanisms in pediatric. cardiovascular disease. Wendy A. Luce (Childrens Research Institute), Mandar S. Joshi (Center for Cardiovascular Medicine, Columbus), Timothy M. Hoffman, Timothy (Columbus Children's Heart Center), F. Feltes (Childrens Research Institute) & John Anthony. Bauer (Wexner Child Hospital, Ohio State University). 3 Heart failure–role of autoimmunity. Urs Eriksson (Universitatsspital). 4 Immune basis of hypertension in humans. Katherine Horak (Sarver Heart Center, The University of Arizona) & Douglas F. Larson (Sarver Heart Center In the School of Medicine). 5 Immune dysregulation: potential mediator of. metabolic syndrome-induced cardiac. remodeling. Sherma Zibadi (The University of Arizona), Douglas F. Larson (Sarver Heart Center In the School of Medicine) & Ronald. Ross Watson (Sarver Heart Center in the School of Medicine). 6 T helper 2 cell cytokines in remodeling of. aortic wall. W. L. Chan (William Harvey Research Institute). 7 Effects of TNF- on cardiac function. Bo Yang (University of Arizona) & Douglas F. Larson (Sarver Heart Center In the School of Medicine). 8 Immunosuppression in promotion of cardiac. allograft vasculopathy. Farzad Moien-Afshari (University of British Columbia), Jonathan Choy (Department of Pharmacology and Therapeutics), Bruce. M. McManus (Department of Pharmacology and Therapeutics) & Ismail Laher (University of British Columbia). 9 Immunotherapy for left. ventricular dysfunction after. heart transplantation. Charles E. Canter (Washington University School of Medicine). Part II Immune dysfunction promoting. CVD: induction by transplantation. drugs. 10 Immunomodulating therapy in chronic heart. failure. Lars Gullestad (Department of Cardiology, University of Oslo, N-0027 Oslo, Norway). , Jan Kristian Dam°as (Research Institute for Internal Medicine),. Arne Yndestad (Research Institute for Internal Medicine, University of Oslo) & P°al Aukrust (Rikshospitalet). 11 Statins in atherosclerosis: role of immune. regulation. Claire Arnaud & Fran¸cois Mach (Foundation for Medical Research). 12 ACE inhibitors as immunomodulators:. treatment of cardiovascular disease. Christina Grothusen (Dept. of Cardiology and Angiology) & Bernhard Schieffer (Department of Cardiology and Angiology). 13 Treatment of heart failure by anticytokine. therapies. Donna L. Vredevoe (University of California, Los Angeles) & Julia R. Gage (Kendle International, Inc., Thousand Oaks, CA). Part III Immune dysfunction leading to. heart dysfunction: induction or. prevention by cardiotherapeutic. drugs. 14 Pathogenesis of cardiovascular complications. in the acquired immunodeficiency. syndrome. Giuseppe Barbaro (University “La Sapienza”). 15 Cytokines and T cell-mediated responses in. autoimmune myocarditis. Jin Zhang (The Proctor and Gamble Company). 16 Drugs of abuse: accentuation of. immunomodulation of viral myocarditis. Oana Madalina Petrescu (Caritas St. Elizabeth's Medical Center, Boston) & James P. Morgan (Department of Medicine). Part IV Immune dysfunction leading to. heart disease: induction by. pathogens. 17 Osteopontin: the link between the immune. system and cardiac remodeling. Samira Najmaii (Sarver Heart Center, The University of Arizona), Qianli Yu (Sarver Heart Center) & Douglas. F. Larson (Sarver Heart Center In the School of Medicine). 18 Inflammatory immune activation in heart. failure patients: therapeutic implications. Mohammad Abraham Kazemizadeh Gol (University of Minnesota) &. Mohsen Araghi-Niknam (CRM Clinical Research). 19 Role of innate immune dysregulation in. diabetic heart failure. Betsy B. Dokken (University of Arizona School of Medicine) & Paul F. McDonagh (Allan C. Hudson and Helen Lovaas Endowed Chair of Vascular Biology and Coagulation). 20 Tolerance in heart transplantation: current. and future role. Kimberly Gandy (University of Arizona), Jos Domen (Department of Surgery) & Jack. Copeland (Department of Surgery). 21 Neutralization of Th2 cytokines in therapy of. cardiovascular pathology. A. Mandel (Director of Fundamental & Medical Research) & A. E. Bolton (Vasogen Ireland Limited). 22 Anti-inflammatory immune therapy in heart. disease. David Chen (The Methodist DeBakey Heart Center), Christian Assad-Kottner (The Methodist DeBakey Heart Center),. Francisco J. Cordova (The Methodist DeBakey Heart Center), Carlos Orrego (The Methodist DeBakey Heart Center) &. Guillermo Torre-Amione (The Methodist DeBakey Heart Center). 23 Cholesterol, interleukin-6 inflammation, and. atherosclerosis—role of statins,. bisphosphonates, and plant polyphenols in. atherosclerosis and other diseases of. aging. Sota Omoigui (L. A. Pain Clinic - medcinehouse.com). 24 Autoimmune myocarditis: treatment with. anti-T-cell antibodies. Zofia T. Bilin´ska & Witold Ruzytto. 25 Immunosuppressive therapy to counter. cardiac allograft vasculopathy. Carl V. Leier (Division of Cardiovascular Medicine). 26 Role of oral pathogens in the pathogenesis of. coronary heart disease. Palle Holmstrup (University of Copenhagen, Department of Periodontology). 27 Myocardial regenerative potential by stem cell. transplant. Yinhong Chen (Geron Corporation), Catherine A. Priest (Geron Corporation) &. Joseph D. Gold (Director of Stem Cell Biology and Research Questions). 28 Bioflavanoids and dietary anti-inflammatory. actions: role in cardiovascular diseases. Simin Bolourchi-Vaghefi (University of North Florida College of Health) & Amy Galena (Clinical dietitian). Index

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Book SynopsisThis lively handbook on the fundamentals of Evidence-based Medicine (EBM) leads the reader, step by step, through a process that proceeds from a patient's medical history, via information searches and critical appraisal of the literature, to recommendations for treatment. Using a simple four-step approach, the author illustrates how to develop better questions and more effective searches, resulting in objective and clinically relevant information that can be evaluated and implemented in day-to-day practice. Sherlock Holmes and Dr Watson, the famous fictional detectives, assist throughout, drawing parallels between criminal and medical investigation, and simplifying the processes and themes of EBM. Evidence-Based Medicine in Sherlock Holmes' Footsteps is a concise, accessible and instructive introduction to EBM for medical students, health care trainees, doctors and allied health professionals, and a valuable resource for anyone wanting to improve their ability tTrade Review"A useful and introductory book … Small and easy to read. The arrangement and layout of the book are easy on the eye … Some interesting examples used to explain some of the basic concepts." (Evidence Based Medicine, August 2008) "Small enough to read on the bus to placement but contains enough 'meat' to keep you entertained. It is clearly set out, and using Sherlock Holmes' steps really makes it a novel and interesting read. I think it's the best evidence based decision making book I have read." (The Placebo Effect, HYMS Gazette) “Based on a solid foundation…concise…handbook that learners and practitioners alike could easily carry around…In this regard, the book is quite a success.” (Canadian Medical Association Journal) Reviews of the original Swedish publication ”The entertaining analogy between critical appraisal and Sherlock Holmes´detective work, with well-found and appropriate quotations, makes the reading a pure pleasure.” (Läkartidningen 2004; 40:3100-1) ”The book is a little pearl and is warmly recommended.” (Ugeskrift for Laeger 2004; 18 October:43) ”The author has succeeded in creating a comprehensive, relevant and at times witty book. It is a useful and readable introduction [to EBM] that is warmly recommended.” (Tidskrift for den Norske Laegeforening 2005;1:125) ”[The author]has written an ingenious book, a compact EBM textbook in a light format, with a twinkle in his eye. The subject has been packaged for easy digetion – fish liver oil encapsulated in candy.” (Lääkärilehti 2005;3:322) ”This book written by Surgery Professor J.N. is a little pearl! Not only is it tasteful, humorous and well structured; it is also comprehensive, nutritious and – most importantly- understandable in an area where other more voluminous books fail.” (Svensk Bibliotekstjänst 2004:15)Table of ContentsFOREWORD. INTRODUCTION. STEP 1 FORMULATE AN ANSWERABLE QUESTION. Information Sources. Choosing the Appropriate Database. Systematic Reviews/Meta-Analysis. Meta-Search Engines. Clinical Practice Guidelines. Critically Appraised Topics (CATs). Primary Information Sources. Library Resources. Other EBM Portals. STEP 2 INFORMATION SEARCH. Make a Wide Search with High Sensitivity. Principal Database Search Strategy. Limit Your Search Results/Increase Your Specificity. Use a Good Hit for Further Searches. STEP 3 REVIEW OF INFORMATION AND CRITICAL APPRAISAL. Quality Assessment of Information. Evaluation of the Scientific Quality. Quality of Evidence. STEP 4 EMPLOY THE RESULTS IN YOUR DAILY PRACTICE. Applicability. Balance between Benefit and Harm. Strength of Recommendation. Patient’s Perceptions. Make a Recommendation. Communicating the Evidence to Your Patient. DEDUCTION, ANALYSIS AND MEDICINE. REFERENCES. SUMMARY OF INFORMATION SOURCES AND SEARCH ENGINES. INTERNET-BASED SPREADSHEETS. SHERLOCK HOLMES REFERENCES. LIST OF ILLUSTRATIONS. RECOMMENDED EBM LITERATURE. GLOSSARY. INDEX

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Book SynopsisCatheter Ablation of Atrial Fibrillation Edited by Etienne Aliot, MD, FESC, FACC, FHRS Chief of Cardiology, Hopital Central, University of Nancy, France Michel Haissaguerre, MD Chief of Electrophysiology, Hopital Cardiologique du Haut-Leveque, France Warren M.Table of ContentsPart 1 Fundamental concepts of atrial fibrillation. Chapter 1 Anatomy of the left atrium relevant to atrial fibrillation ablation. Chapter 2 Mechanisms and significance of fractionated electrograms recorded during atrial fibrillation. Chapter 3 Computer simulation studies of atrial fibrillation. Chapter 4 Experimental and theoretical insights into fundamental mechanisms of antiarrhythmic drug actions on atrial fibrillation: prospects for improved pharmacotherapy. Chapter 5 Mechanisms of atrial fibrillation in animals and humans. Chapter 6 Three-dimensional images in catheter ablation of atrial fibrillation. Chapter 7 Signal processing of fibrillatory electrograms. Part 2 Practical approaches in atrial fibrillation. Chapter 8 Emerging technologies in the treatment of atrial fibrillation. Chapter 9 Techniques targeting the pulmonary veins. Chapter 10 Techniques of linear lesion for atrial fibrillation ablation. Chapter 11 Ablation strategies in paroxysmal atrial fibrillation. Chapter 12 Ablation strategies in chronic atrial fibrillation. Part 3 Special challenges in atrial fibrillation. Chapter 13 Diagnostic algorithm of atrial tachycardia following atrial fibrillation ablation: importance of localized reentries. Chapter 14 Catheter ablation of atrial fibrillation in patients with heart failure. Chapter 15 Morbidity and mortality of ablation versus drugs. Chapter 16 Atrial mechanical function after atrial fibrillation ablation. Chapter 17 Surgery for atrial fibrillation: from scalpel to catheter . . . and back?. Chapter 18 Electrogram-guided approach to ablation of atrial fibrillation

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Book SynopsisAccurate interpretation of the ECG is an essential skill for all health professionals. Using a unique self-assessment format, this book presents a comprehensive, incremental approach to ECG interpretation, progressing from basic to advanced concepts in electrocardiography. Amply illustrated with electrocardiograms both in the main text and the self-assessments, ECG Interpretation is a must-have practical guide that features: An appealing, user-friendly format that will help with exam preparation Clearly defined learning objectives to guide readers efficiently through the intricacies of ECG interpretation Numerous practical examples of ECG strips to illustrate important concepts, including clean ECG strips to practice skills Multiple-choice questions to consolidate learning and emphasize pertinent facts This second edition has been thoroughly revised from the original 12-lead ECG Interpretation: The Self-Assessment Approach, with fullTable of Contents1 Complexes and intervals. 2 Mean QRS axis determination. 3 The normal electrocardiogram. Self-Assessment Test One. 4 Intraventricular conduction defects. 5 Myocardial ischemia and infarction. Self-Assessment Test Two. 6 Chamber enlargement and hypertrophy. 7 Acute pericarditis. 8 Sinus rhythm and its discontents. Self-Assessment Test Three. 9 Atrioventricular block. 10 Atrial arrhythmias. Self-Assessment Test Four. 11 Supraventricular re-entrant tachycardia. 12 The Wolff–Parkinson–White syndrome. Self-Assessment Test Five. 13 Junctional arrhythmias. 14 Ventricular arrhythmias. 15 The channelopathies. 16 Electronic pacing. Self-Assessment Test Six. Further reading. Answers to self-assessment tests. Index

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Book SynopsisContains over one thousand practice questions - worked examples, quick tests, 2 full BMAT-style sample test papers, and 2 full UKCAT-style sample test papers. With the use of admissions tests becoming an increasingly more common part of the selection process for entrance to medical school, BMAT and UKCAT Uncovered is a comprehensive yet accessible guide to the two main tests used by UK medical schools. Written by recent Cambridge graduates, the authors'' experience lies in taking these exams themselves and teaching students how to pass them. They combine key strategies for tackling the specific skills tested by the BioMedical Admissions Test and the UK Clinical Aptitude Test, along with practice questions and tests, with worked answers, in the style of the BMAT and UKCAT exams. The simple, informal teaching style, highlighting key practice areas, with the minimal use of jargon, means BMAT and UKCAT Uncovered is an essential tool for all medical scTable of ContentsForeword. Preface. 1. Quantitative Analysis for the BMAT and the UKCAT. 2. Critical Analysis for the BMAT and the UKCAT. 3. Scientific Knowledge and Application for the BMAT. 4. The Writing Task for the BMAT. 5. Abstract Reasoning for the UKCAT. 6. Decision Analysis for the UKCAT. 7. BMAT Practice Papers. 8. UKCAT Practice Papers. 9. Solutions. Index

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Book SynopsisThis book brings the recent dramatic changes in the field of cardiovascular imaging into the clinical setting to enable the clinician to best use the technology at hand. Novel Techniques for Imaging the Heart opens with three chapters reviewing the general considerations and fundamentals of imaging, followed by a series of chapters that address clinical applications of CT and CMR, including critical review of imaging approaches for diagnosis and prognosis of CAD evaluating the patient with new onset heart failure evaluating the patient before non-cardiac surgery evaluating the patient before interventional electrophysiology novel assessment of vascular flow and valvular disease relative merits of CTA and MRA for coronary artery imaging The final section deals with advanced applications of CT and MR imaging, considers technical advances and future prospects of high field MRI, and concludes with a chapter Trade Review"This book will provide evidence and update the interested reader on two non-invasive, and often complimentary, exciting advanced imaging techniques: cardiac MR and cardiac CT." (Cardiology News, 1 December 2011)Table of ContentsContributors. Preface. Forewords. PART I General Considerations and Fundamentals of Imaging. 1 Principles of CT and MRI (Leon Axel and Danny Kim). 2 Clinical Considerations on the Use of Contrast Agents for CT and MRI (Federico E. Mordini and Robert R. Edelman). 3 Radiation Dose Considerations in Cardiac CT (Mannudeep K. Kalra and Suhny Abbara). 4 Safety Considerations of Current and Evolving CMR Techniques and Hardware (Saman Nazarian, Henry R. Halperin, and David A. Bluemke). PART II Clinical Applications of CT and CMR Imaging. 5 Evaluating the Symptomatic Patient with Suspected CAD (Bernhard L. Gerber). 6 Evaluation of Atherosclerotic Plaques with CT and MRI (Ilan Gottlieb and Jo˜ao A.C. Lima). 7 Evaluating Chest Pain in Patients with Known CAD (Amit R. Patel and Christopher M. Kramer). 8 Evaluating the Patient with LV Dysfunction for Potential Revascularization (Michael Salerno, Han W. Kim, and Raymond J. Kim). 9 Role of Hybrid Imaging: PET/CT and SPECT/CT (Marcelo F. Di Carli). 10 Critical Review of Imaging Approaches for the Diagnosis and Prognosis of CAD (Rory Hachamovitch and George A. Beller). 11 Evaluating the Patient with New Onset Heart Failure (Joseph B. Selvanayagam and Theodoros D. Karamitsos). 12 Evaluating the Patient before Noncardiac Surgery (William O. Ntim, Rahul Aggarwal, and W. Gregory Hundley). 13 Evaluating the Patient before Interventional Electrophysiology (Riple J. Hansalia and Mario J. Garcia). 14 Assessment of Blood Flow and Heart Valve Disease by CMR (Philip J. Kilner). 15 Relative Merits of CTA and MRA for Coronary Artery Imaging (Xin Liu, James C. Carr, and Debiao Li). 16 Can Atherosclerosis Imaging Improve Patient Management? (Allen J. Taylor and Robert O. Bonow). PART III Advanced Applications of CT and CMR Imaging. 17 Atherosclerosis Imaging: A Biological and Clinical Perspective (Peter Libby). 18 Stem Cell Imaging (Dara L. Kraitchman). 19 Myocardial Imaging in CAD: Beyond Ischemia and Viability (Susan H. Kwon, Henry Wu, and Raymond Y. Kwong). 20 Technical Advances and the Future Prospects of High Field Strength MRI (Ahmed M. Gharib, Matthias Stuber, and Roderic I. Pettigrew). 21 Technical Advances in MDCT for Imaging Coronary Artery Stenoses and Physiology (Humberto Wong, Elsie T. Nguyen, and Geoffrey D. Rubin). 22 Imaging of Myocardial Mechanics (Hiroshi Ashikaga and Elliot R. McVeigh). 23 Cardiovascular Interventional MRI (Colin Berry and Robert J. Lederman). Index. A companion CD-ROM with video clips is included at the back of the book.

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Book SynopsisBiomarkers in Heart Disease is the first title in the AHA Clinical Series and is aimed at meeting the needs of clinicians, providing cardiologists, internists, emergency physicians, laboratorians, and other healthcare providers with a clear understanding of the role of biomarkers in contemporary cardiovascular medicine.Trade Review“A vital contribution to a high-interest and emerging field, this comprehensive but concise discussion of the role of biomarkers in contemporary cardiovascular medicine focuses both on indications for biomarkers in current use as well as on new biomarkers. It is an essential read for anyone interested in the use of biomarkers in clinical practice. The quality and content of the book is excellent. It is a valuable resource for cardiovascular physicians, midlevel providers, or students in a rapidly changing field of cardiovascular medicine.” Doodys ReviewsTable of ContentsPart I Biomarkers for the Evaluation of Patients with Ischemic Heart Disease. 1 Protocols for Diagnosing Myocardial Infarction. 2 Troponin and Other Markers of Necrosis for Risk Stratification in Patients with Acute Coronary Syndromes. 3 Challenges Interpreting Cardiac Troponin Values. 4 Natriuretic Peptides and Inflammatory Markers for Risk Stratification in Patients with Ischemic Heart Disease. 5 Novel Markers in Patients with Suspected ACS. Part II Biomarkers for Evaluation of Patients with Heart Failure. 6 Use of Natriuretic Peptides in the Diagnosis of Heart Failure. 7 Biomarkers for Risk Stratification in Patients with Heart Failure. 8 Natriuretic Peptides for Disease Monitoring in Patients with Chronic Heart Failure. Part III Biomarkers for Screening in the Ambulatory Populations. 9 CRP. 10 Newer Markers for Population Screening. Part IV A Look to the Future. 11 Moving Toward Personalized Medicine.

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Book SynopsisChronic pain is a very common problem, impacting on many patients. Assessment and management can be challenging. The ABC of Pain focuses on the pain management issues often encountered in primary care.Table of ContentsContributors vii Preface ix 1 Epidemiology of Chronic Pain 1 Blair H Smith and Nicola Torrance 2 Pain Mechanisms 5 Carole Torsney and Susan Fleetwood-Walker 3 Evaluation of the Patient in Pain 11 Dennis C Turk and Kimberly S Swanson 4 Chronic Musculoskeletal Pain 16 Paul Dieppe 5 Management of Low Back Pain 20 James Campbell and Lesley A Colvin 6 Neuropathic Pain 25 Lesley A Colvin and Suzanne Carty 7 Visceral Pain 31 James Maybin and Michael G Serpell 8 Post-surgical Pain 37 Susan Nimmo and Lesley Dickson 9 Headache and Orofacial Pain 42 Anne MacGregor and Joanna M Zakrzewska 10 Cancer Pain 48 Marie Fallon 11 Treating Pain in Patients with Drug-dependence Problems 54 Jane C Ballantyne 12 Pain in Children 60 Suellen M Walker 13 Pain in Older Adults 65 Debra K Weiner 14 Pain in Pregnancy 69 George R Harrison 15 Psychological Aspects of Chronic Pain 73 David Gillanders 16 Interventional Procedures in Pain Management 79 Dominic Hegarty and Damian Murphy 17 The Role of Physiotherapy in Pain Management 86 Paul J Watson 18 The Role of Transcutaneous Electrical Nerve Stimulation (TENS) in Pain Management 91 Mark I Johnson 19 Complementary and Alternative Strategies 99 Margaret Cullen and Fiona MacPherson 20 Opioids in Chronic Non-malignant Pain 103 Eija Kalso Index 109

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Book SynopsisSyncope is one of the most important causes of transient loss of consciousness, and is such a common event that it may be encountered by practitioners in virtually any field of medicine. As such, a broad spectrum of healthcare professionals may be involved in its assessment and management. Edited by distinguished individuals whose pioneering work in syncope highlights careers devoted to improving patient care, this book provides: Succinct, practical and up-to-date guidance on the optimal clinical evaluation and treatment of patients with syncope and transient loss of consciousness in a multidisciplinary framework Evidence-based recommendations founded on comprehensive literature review and extensive clinical experience by expert contributors Meaningful clinical tips for appropriate use of guidelines in clinical practice Key recent citations Building on the European Society of Cardiology Syncope Guidelines, this book provides a clear evTable of ContentsContributors. Preface. Part 1 Syncope and TLOC overview. 1 Definition and classification of syncope and transient. loss of consciousness. Jean-Jacques Blanc. 2 Epidemiologic aspects of transient loss of consciousness/syncope. Robert S Sheldon, Anna Serletis. 3 Pathophysiology of syncope: postural, neurally-mediated,. and arrhythmic. W Wieling. 4 Cerebral perfusion in syncope. J Gert van Dijk, Roland D Thijs. 5 Risk stratification—impact on diagnostic strategy. Brian Olshansky. Part 2 Clinical evaluation strategies. 6 Value and limitations of clinical history in assessing cause of syncope. Paolo Alboni, Maurizio Dinelli. 7 Emergency department evaluation of transient loss of consciousness/. syncope. Franc¸ois P Sarasin. 8 The essential autonomic assessment for evaluating the. cause of syncope. Carlos A Morillo, Juan C Guzman. 9 Neurally-mediated reflex syncope: recognition by history and. clinical testing. Anna Serletis, Robert S Sheldon. 10 Value and limitations of ambulatory electrocardiographic monitoring. Andrew D Krahn. 11 Recording ambulatory blood pressure in the syncope and. TLOC evaluation. Dietrich Andresen. 12 Electrophysiologic testing: value and limitations in the transient loss of. consciousness/syncope evaluation. Suneet Mittal. 13 Intolerance to upright posture in autonomic failure and the postural. tachycardia syndrome: assessment and treatment strategies. Christopher J Mathias. 14 Improving tolerance to upright posture: current status of tilt-training. and other physical maneuvers. Hugo Ector, Tony Reybrouck. 15 Syncope in patients with bundle-branch block and other conduction. system abnormalities. Angel Moya. Part 3 Specific conditions. 16 Treatment strategies in neurally-mediated reflex syncope: effectiveness of. drugs, pacing, and physical maneuvers. Richard Sutton. 17 Structural heart disease, syncope, and risk of sudden death: selection of. patients for implantable cardioverter-defibrillator therapy. Kathy L Lee, Hung-Fat Tse, Chu-Pak Lau. 18 Channelopathies as a cause of syncope. T Boussy, Pedro Brugada. 19 Distinguishing seizures and pseudosyncope from syncope. Adam P Fitzpatrick. 20 Syncope and transient loss of consciousness in children and adolescents:. congenital and acquired conditions. Hugh Calkins. 21 Transient loss of consciousness, syncope, and falls in the elderly. Rose Anne Kenny. 22 Drug-induced (iatrogenic) syncope. Gerald V Naccarelli. Part 4 Economic and research aspects. 23 Syncope and the competitive athlete: recommendations for evaluation. and permission to compete. Franco Giada, Antonio Raviele (Ospedale Umberto I). 24 Role of syncope management units. Win K Shen, Michele Brignole (Ospedali del Tigullio). 25 The impact of syncope and transient loss of consciousness on. quality of life. Blair P Grubb. Part 5 Current controversies and future directions. 26 Driving and flying restrictions for the syncope and/or implanted. cardiac device patient. Christina M Murray, Dwight W Reynolds. 27 Clinical trials landscape: what’s new, what’s ongoing, what do. we need. Michele Brignole (Ospedali del Tigullio), David G Benditt (University of Minnesota Medical School), Wouter Wieling (Academic Medical Centre). 28 Syncope and transient loss of consciousness: multidisciplinary. management. A John Camm. 29 Syncope practice guidelines initiative. David G Benditt (University of Minnesota Medical School). Appendix: syncope consortium members. Index

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Book SynopsisTHE AHA CLINICAL SERIES ELLIOTT ANTMAN, MD, SERIES EDITOR The strategic driving force behind the American Heart Association's mission of healthier lives free of cardiovascular disease and stroke is to change practice by providing information and solutions to healthcare professionals.Trade Review“This thorough book addresses the topic in a concise manner. It can be used as a quick reference by busy practitioners or as a teaching guide for students.” (Doody's Reviews, June 2009)Table of ContentsPart I Concepts in Platelet Physiology, Function and Measurement. 1 Platelet physiology and the role of the platelet in ischemic heart disease. Robert F. Storey . 2 Laboratory assessment of platelet function and the effects of antiplatelet agents. Alan D. Michelson, A.L. Frelinger . Part II Pharmacology of Oral Antiplatelet Agents. 3 Cyclooxygenase inhibitors. Nina Chetty Raju, John W. Eikelboom . 4 Aspirin response variability and resistance. Wai-Hong Chen, Daniel I. Simon . 5 P2Y12 inhibitors: Thienopyridines and direct oral inhibitors. Jean-Philippe Collet, Boris Aleil, Christian Gachet, Gilles Montalescot . 6 Thienopyridine response variability and resistance. Udaya S. Tantry, Thomas A. Suarez, Paul A. Gurbel . Part III Pharmacology of Intravenous Antiplatelet Agents. 7 Pharmacology of intravenous glycoprotein IIb/IIIa antagonists. James C. Blankenship, Peter B. Berger . 8 Intravenous P2Y12 inhibitors. Steven P. Dunn, Steven R. Steinhubl . 9 Antiplatelet effects of thrombin inhibitors and fibrinolytic agents. Nicolai Mejevoi, Anjum Tanwir, Marc Cohen . Part IV Clinical Use of Antiplatelet Agents in Cardiovascular Disease. 10 Antiplatelet therapy in acute coronary syndrome with ST elevation. Christian W. Hamm . 11 Antiplatelet therapy in ST-elevation myocardial infarction. Michelle O'Donoghue, Marc S. Sabatine . 12 Antiplatelet therapy in chronic artery disease. Kamran I. Muhammed, Deepak L. Bhatt . 13 Antiplatelet therapy in peripheral arterial disease. Esther S. Kim, Heather L. Gornik . 14 Clinical use of antiplatelet agents in cardiovascular disease: cerebrovascular diseases. Larry B. Goldstein . Part V Special Circumstances. 15 Antiplatelet therapy and coronary bypass surgery: risks and benefits. A. Burdess, N.L. Cruden, K.A. Fox . 16 Management of antiplatelet therapy for non-cardiac surgery. Nisheeth Goel, John F. Canales, James J. Ferguson . 17 Antiplatelet therapy and coronary stents. Alanna Coolong, Laura Mauri

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Book SynopsisReaching a provisional diagnosis is the most difficult part of any General Practitioner (GP) consultation. The subsequent formulation of a management plan is often straightforward. This book focuses entirely on formulating likely diagnoses rather than the investigation or management of them.Trade Review"I liked the layout as it is easy on the eye and simple to find what you are looking for if you are searching for a particular symptom. The index is searchable by symptom and by disease" (Royal College of General Practitioners, 1 May 2011) “This is a highly useful book to keep readily available in the outpatient office as a memory aid when confronted with a less-than-textbook presentation of symptoms.” (Doody’s , August 2009)Table of ContentsAcknowledgements vi Preface vii List of Abbreviations and Symbols viii Chapter 1: Head and Neck 1 Chapter 2: Ophthalmology 7 Chapter 3: Ear, Nose and Throat 14 Chapter 4: Thorax 24 Chapter 5: Abdomen 37 Chapter 6: Urinary Tract 58 Chapter 7: Women’s Health 65 Chapter 8: Men’s Health 81 Chapter 9: Musculoskeletal 90 Chapter 10: Skin, Hair and Nails 109 Chapter 11: Mental Health 137 Chapter 12: Miscellaneous 144 Index 167

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Book SynopsisWritten, reviewed, and edited in a collaborative effort by cardiology fellows and faculty of one of the most prestigious academic centers in the country, this concise volume gives cardiology fellows the book they have long needed.Trade Review“Practical and easily accessible at the time of decision making, the book relays important concepts through concise and to-the-point pearls and by utilizing algorithm charts and illustrations.” (Kingbook73's Medical Ebook and Video Collection, 15 October 2014) "This is a very good source of general information about current cardiovascular practice on a basic level. It is easy to read and follow with a special focus on contemporary guidelines and practices. What makes this book attractive is that it is easy to read." (Doody's, 27 January 2012) "An accurately titled short reference work, this book is leading out in seven sections of 29 chapters dealing with prevention, clinical aspects of a heart attack, heart failure, valvular disease and vascular disease, arrhythmias and sudden cardiac death, cardiovascular disease in special population and specialised testing and therapeutics." (British Journal of Cardiology, 2011)Table of ContentsContributors, viii List of Abbreviations, xi Foreword, xv Section I Preventive Cardiology. Chapter 1 Prevention of Cardiovascular Disease, 3 Maulik Shah and Reza Ardehali Chapter 2 Dyslipidemia, 11 Karim Sallam and Reza Ardehali Chapter 3 Hypertension, 21 Christopher Woods and Richard Lafayette Section II Coronary Artery Disease. Chapter 4 Stable Angina, 35 Joshua Lehrer and William F. Fearon Chapter 5 Unstable Angina and Non-ST Elevation Myocardial Infarction, 43 Joshua Lehrer and David P. Lee Chapter 6 ST-Elevation Myocardial Infarction, 53 Yen Tibayan Section III Heart Failure. Chapter 7 Care of the Cardiomyopathic Patient, 69 Nicholas J. Leeper, Reza Ardehali, and Michael Fowler Chapter 8 Pulmonary Hypertension and Right Heart Failure, 81 Matthew T. Wheeler and Roham T. Zamanian Chapter 9 Heart Transplantation, 94 Jesus Almendral, Robert Maranda, and Sharon Hunt Section IV Valvular and Vascular Disease. Chapter 10 Valvular Heart Disease, 119 Reza Ardehali and Ingela Schnittger Chapter 11 Diseases of the Aorta, 139 Michael Ho and David Liang Chapter 12 Peripheral Vascular Disease, 154 Andrew Wilson, Reza Ardehali, and John Cooke Section V Arrhythmias and Sudden Cardiac Death. Chapter 13 Atrial Fibrillation and Flutter, 165 Marco Perez and Amin Al-Ahmad Chapter 14 Supraventricular Tachycardia, 177 Marco Perez and Paul Zei Chapter 15 Ventricular Tachycardia, 194 Jeffrey Hsing and Henry Hsia Chapter 16 Bradycardia, 204 Jeffrey Hsing and Paul Wang Chapter 17 Syncope, 212 Farheen Shirazi and Karen Friday Section VI Cardiovascular Disease in Special Populations. Chapter 18 Congenital Heart Disease, 227 Patrick Yue Chapter 19 Cardiology Consultation and Management of Perioperative Complications, 239 Azar Mehdizadeh and Stanley G. Rockson Chapter 20 Management of Pre- and Post-Cardiac Surgery Patients, 248 Mohammad Haghdoost and Ramin Beygui Section VII Specialized Testing and Therapeutics. Chapter 21 Adult Advanced Cardiac Life Support, 263 Anurag Gupta and Amin Al-Ahmad Chapter 22 ECG Interpretation, 272 Marco Perez and Victor F. Froelicher Chapter 23 Transthoracic and Transesophageal Echocardiography, 283 Shahriar Heidary and Ingela Schnittger Chapter 24 Noninvasive Stress Testing, 293 Arvindh Kanagasundram and Victor F. Froelicher Chapter 25 Cardiac MRI and CT, 303 Chandra Katikireddy and Michael V. McConnell Chapter 26 Clinical Cardiac Hemodynamics, 326 Shirley Park and Euan Ashley Chapter 27 Percutaneous Interventions, 340 Aiden O'Loughlin and Alan Yeung Chapter 28 Pacemakers and ICD Troubleshooting, 360 Marco Perez and Paul Wang Chapter 29 Introduction to Electrophysiology Studies, 370 Ronald Lo and Henry Hsia Index, 381

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Book SynopsisNow that state of the art equipment can be carried in ambulances, prehospital emergency staff are able to perform an ECG soon after arrival on scene, enabling the EMS provider to gather important diagnostic information that can not only guide prehospital therapy but also direct hospital-based treatment.Table of ContentsList of Contributors ix Foreword xi Preface xiii Section 1 The ECG in Prehospital Patient Care 1 1 Clinical applications of the electrocardiogram (ECG) 3 Robert C. Schutt William J. Brady and Steven H. Mitchell 2 Clinical impact of the electrocardiogram (ECG) 7 Robert C. Schutt William J. Brady and Steven H. Mitchell 3 Interpretation of the electrocardiogram – single-, multi-, and 12-lead analysis 12 Robert C. Reiser Robert C. Schutt and William J. Brady 4 Variants of the normal, lead misplacement, and electrocardiographic artifact encountered in clinical practice 17 Robert C. Reiser Robert C. Schutt and William J. Brady Section 2 Cardiac Rhythms and Cardiac Dysrhythmias 23 5 Cardiac rhythms with normal rates 25 Korin B. Hudson and William J. Brady 6 Narrow QRS complex tachycardia 29 Courtney B. Saunders and Jeffrey D. Ferguson 7 Wide QRS complex tachycardia 37 Michael Levy and Francis X. Nolan Jr 8 Bradycardia 44 Korin B. Hudson J. Aidan Boswick and William J. Brady 9 Atrioventricular conduction block 50 Steven H. Mitchell Korin B. Hudson and William J. Brady 10 Intraventricular conduction block: bundle branch block and other conduction abnormalities 54 Steven H. Mitchell Richard B. Utarnachitt and William J. Brady 11 Atrial and ventricular ectopic beats 62 Jeffrey D. Ferguson Michael Levy J. Aidan Boswick and William J. Brady Section 3 Acute Coronary Syndrome and the 12-Lead ECG 67 12 Ischemic heart disease: anatomic and physiologic considerations 69 Peter Pollak Peter Monteleone Kelly Williamson David Carlberg and William J. Brady 13 Historical development of the prehospital electrocardiogram (ECG) 76 Erik Iszkula David Carlberg and William J. Brady 14 Electrocardiographic findings in acute coronary syndrome 79 Peter Monteleone Peter Pollak David Carlberg and William J. Brady Section 4 Special Populations High-Risk Presentation Scenarios and Advanced Electrocardiographic Techniques 95 15 The electrocardiogram in the pediatric patient 97 Robert Rutherford Robin Naples and William J. Brady 16 The electrocardiogram in the poisoned patient 104 Steven H. Mitchell Christopher P. Holstege and William J. Brady 17 The electrocardiogram in hyperkalemia 112 Steven H. Mitchell and William J. Brady 18 Life-threatening electrocardiographic patterns 117 Steven H. Mitchell Richard B. Utarnachitt and William J. Brady 19 The electrocardiogram in patients with implanted devices 122 Amita Sudhir and William J. Brady 20 Electrocardiographic tools in prehospital care 127 Robin Naples Alvin Wang and William J. Brady 21 Wolff-Parkinson-White syndrome 134 William J. Brady 22 Cardiac arrest rhythms 138 Amita Sudhir and William J. Brady Section 5 Electrocardiographic Differential Diagnosis of Common ECG Presentations 145 23 Electrocardiographic differential diagnosis of narrow complex tachycardia 147 Megan Starling and William J. Brady 24 Electrocardiographic differential diagnosis of wide complex tachycardia 152 Amita Sudhir and William J. Brady 25 Electrocardiographic differential diagnosis of bradyarrhythmia 161 Megan Starling and William J. Brady 26 Electrocardiographic differential diagnosis of ST segment elevation 165 Megan Starling and William J. Brady 27 Electrocardiographic differential diagnosis of ST segment depression 176 Amita Sudhir and William J. Brady 28 Electrocardiographic differential diagnosis of T wave abnormalities: the prominent T wave and T wave inversions 183 Amita Sudhir and William J. Brady Index 195

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Book SynopsisThe need for evidence-based decisions that take account of both effectiveness and economics is greater now than ever. Using case studies and illustrative examples throughout the authors describe how the activities and outputs of evidence synthesis, systematic review, economic analysis and decision-making interact within and across different spheres of health and social policy and practice. Expanding on the first edition the book now covers approaches to evidence synthesis that combine economics and systematic review methods in the applied fields of social welfare, education and criminal justice, as well as health care. Written by economists and health services researchers closely involved in developing evidence-based policy and practice it showcases current state-of-the-art methodology and will be an invaluable read for all policy-makers and practitioners using evidence to inform decisions, analysts conducting research to support decisions and students discovering the need for evidTable of ContentsPreface 1. From effectiveness to efficiency? An introduction to evidence-based decisions and economics for health care, social welfare, education and criminal justice (Miranda Mugford, Ian Shemilt, Luke Vale, Kevin Marsh, Cam Donaldson, Jacqueline Mallender). 2. The role of review and synthesis methods in decision models (Kevin Marsh). 3. The role of economic perspectives and evidence in systematic review (Rob Anderson, Ian Shemilt). 4. The role of economic evidence in formulation of public policy and practice (Sarah Byford, Barbara Barrett, Richard Dubourg, Jennifer Francis, Jane Sisk). 5. Generalisability, transferability, complexity and relevance (Damian G Walker, Yot Teerawattananon, Rob Anderson, Gerry Richardson). 6. Equity, efficiency and research synthesis (David McDaid, Franco Sassi). 7.Searching for evidence for cost-effectiveness decisions (Julie Glanville, Suzy Paisley). 8. Identifying and reviewing health state utility values for populating decision models (John Brazier, Diana Papaioannou, Anna Cantrell, Suzy Paisley, Kirsten Herrmann). 9. Use of evidence in decision models (Doug Coyle, Karen M Lee, Nicola J Cooper). 10. Grading economic evidence (Massimo Brunetti, Francis Ruiz, Joanne Lord, Silvia Pregno, Andrew D Oxman). 11. Meta-regression models of economics and medical research (TD Stanley). 12. From evidence-based economics to economics-based evidence: using systematic review to inform the design of future research (Ed Wilson, Keith Abrams). 13. Complex problems or simple solutions? Enhancing evidence-based economics to reflect reality (Chantale Lessard, Stephen Birch). 14. Evidence-based decisions and economics: lessons for practice (Luke Vale). 15. Evidence-based decisions and economics: an agenda for research (Michael Drummond). 16. Glossary (Asmaa Abdelhamid, Ian Shemilt). Index.

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Book SynopsisWhen you are ready to implement measures to improve patient safety, this is the book to consult. Charles Vincent, one of the world''s pioneers in patient safety, discusses each and every aspect clearly and compellingly. He reviews the evidence of risks and harms to patients, and he provides practical guidance on implementing safer practices in health care. The second edition puts greater emphasis on this practical side. Examples of team based initiatives show how patient safety can be improved by changing practices, both cultural and technological, throughout whole organisations. Not only does this benefit patients; it also impacts positively on health care delivery, with consequent savings in the economy. Patient Safety has been praised as a gateway to understanding the subject. This second edition is more than that it is a revelation of the pervading influence of health care errors, and a guide to how these can be overcome. ... The beauty of this book is thaTrade Review“Therefore I believe that this book should be read by anyone involved in, or responsible for healthcare.” (Bulletin Royal College of Path, 1 July 2011) “This is a superb book. I can strongly recommend it to all doctors, to medical students, to other clinical staff and to managers who have to try and make sense of the chaotic complexity of healthcare. The author's expertise is demonstrated throughout, and his examples are drawn from UK, American, European healthcare systems, with appropriate comparison across to other industries where they are useful.” (Dr. Nicholas P. G. Davies (Halifax, UK) posted January 1, 2011) "This book is a tremendous asset in advancing the field of patient safety. The book is well-referenced and current and provides a comprehensive yet very readable summary of patient safety. It will serve well anyone who is involved in patient care. In describing this book, the words, "expert", "indispensable", and "worthwhile" come to mind. This is a significant update of the previous edition." (Doody's, 7 October 2011) "The sections on ‘designing out' hospital acquired infection are helpful for infection control staff and architects. Prescribers and pharmacists benefit from seeing how IT can reduce medication errors". (ENT & Audiology News, 1 July 2011)"This book is an outstanding comprehensive overview an summary of the key issues relating to patient safety, as one might hope and expect from one of the leading international experts and researchers in this field." (Casebook, 1 May 2011) "I would recommend this book to all occupational health professionals working in health care, particularly those who sit on clinical risk, infection prevention control or health and safety committees." (Occupational Medicine, 4 June 2011) "This book is highly recommended or anyone in health care with an interest in patient safety. Every practitioner will get something from it." (The Association For Perioperative Practice, 1 March 2011) "This book is directed to those involved in health care and patient safety. It can be used in the classroom setting to illustrate human error and correction methods to provide a safer patient experience. In the institutional setting, this text would be a useful addition to the medical library, as well as personal libraries of physicians, pharmacists, nurses, or other health-care providers interested in patient safety." (The Journal of Pharmacy Technology, 1 March 2011)"This book is essential reading for everyone in health care, but in particular it is a must read for those starting out, training to be the future doctors, nurses, managers and other health-care practitioners." (British Journal of Hospital Medicine, 1 January 2011)Table of ContentsPreface ix The nature of the book xi Inspiration acknowledgements and thanks xiii Section One The Evolution of Patient Safety Chapter 1 Medical harm: a brief history 3 Chapter 2 The emergence of patient safety 14 Chapter 3 Integrating safety and quality 31 Section Two The Hazards of Healthcare Chapter 4 The nature and scale of error and harm 49 Chapter 5 Reporting and learning systems 75 Chapter 6 Measuring safety 96 Section Three From Accident Analysis to System Design Chapter 7 Human error and systems thinking 119 Chapter 8 Understanding how things go wrong 141 Section Four The Aftermath Chapter 9 Caring for patients harmed by treatment 171 Chapter 10 Supporting staff after serious incidents 192 Section Five Design Technology and Standardization Chapter 11 Clinical interventions and process improvement 211 Chapter 12 Design for patient safety 230 Chapter 13 Using information technology to reduce error 246 Section Six People Create Safety Chapter 14 Creating a culture of safety 269 Chapter 15 Patient involvement in patient safety 290 Chapter 16 Procedures violations and migrations 307 Chapter 17 Safety skills 321 Chapter 18 Teams create safety 341 Section Seven The Journey to Safety Chapter 19 Safe organizations: bringing it all together 371 Chapter 20 High performing healthcare systems 390 Index 405

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Book SynopsisA handy, well illustrated aide memoire for any disaster situation Provides rapid access to 80 easy to remember rules for a multiple casualty event Presents each rule followed by concise yet authoritative, evidence-based explanations and guidance A companion to the popular Trauma Rules, 2nd edition (9780727916495) .Trade Review"In twelve short chapters, this excellent and concise pocke-sized book presents 80 ‘disaster rules' concerning triage after chemical, biological, radiological and nuclear incidents". (Emergency Nurse, 1 March 2011)Table of ContentsIntroduction. Chapter 1 Golden Rules. Chapter 2 Command and Control Rules. Chapter 3 Safety Rules. Chapter 4 Communication Rules. Chapter 5 Assessment Rules. Chapter 6 Triage Rules. Chapter 7 Treatment Rules. Chapter 8 Transport Rules. Chapter 9 Hospital Rules. Chapter 10 Mass Gatherings Rules. Chapter 11 Special Incidents Rules. Chapter 12 The Last Rule. Index.

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Book SynopsisCelebrating more than twenty years as the single best source in the field, this Fifth Edition has now expanded into two cornerstone volumes with 53 fully inclusive chapters and 73 renowned contributors that comprehensively address every topic and trend relevant to the identification, diagnosis, and management of endocrine and endocrine-related disorders in children. Substantially revised, the Fifth Edition reflects the current state of the field and analyzes the frequent clinical ailments affecting children. The partner volume covers obesity, diabetes, and insulin resistance and hypoglycemia. This text is devoted to the diseases of the endocrine glands, including disorders of growth, the adrenal cortex and medulla, as well as sexual differentiation, thyroid, and parathyroid conditions and fluid balance alterations.Trade Review"…Pediatric Endocrinology is characterized by an exceptional blend of rigorous scholarship and pragmatism….I congratulate Dr. Lifshitz on admirable accomplishing the monumental task of editing…a textbook of this magnitude and complexity and ensuring that each chapter meets his exacting standards of scholarship, clinical relevance, and clarity of exposition."-Joseph I. Wolfsdorf, Children's Hospital Boston, and Professor of Pediatrics, Harvard Medical School, Boston, Massachusetts, U.S.A. (from the foreword)"…this [textbook] provides the reader with…an update on the latest developments in the field of pediatric endocrinology whil also providing practical information on how this knowledge can be applied to patient care."-Janet Silverstein, Professor of Pediatrics, University of Florida College of Medicine, Gainesville, U.S.A. (from the foreword) "...guides the clinician through thoughtful discussions of the various clinical manifestations of hormone imbalances... This outstanding textbook is of interest to both practicing endocrinologists and general pediatricians. Both groups will be informed and stimulated by its content."-New England Journal of Medicine(for previous edition)"...a useful clinical guide and entry into the field for pediatricians and house staff; it should be a part of every pediatric department library."-Yale Journal of Biology and Medicine (for previous edition)"…a textbook worth the investment, and handy to have on the shelf for both pediatricians and pediatric endocrinologists alike."-Trends in Endocrinology and Metabolism (for previous edition)tbook worth the investment, and handy to have on the shelf for both pediatricians and pediatric endocrinologists alike."-Trends in Endocrinology and Metabolism (for previous edition)Table of ContentsGROWTH & GROWTH DISORDERS. Worrisome Growth. Idiopathic Short Stature. Hypopituitarism and Other Disorders of the Growth Hormone (GH) Insulin Like Growth Factors-I (IGF-I) Axis. Growth Hormone Deficiency in the Adult. Transition from Adolescence to Adulthood. Growth Hormone Treatment. The Skeletal Dysplasias. Overgrowth Syndromes: Evaluation & Management of the Child with Excessive Growth. ADRENAL DISORDERS & SEXUAL DEVELOPMENT ABNORMALITIES. Adrenal Cortex: Hypo and Hyperfunction. An Update of Congenital Adrenal Hyperplasia. Disorders of the Adrenal Medulla- Catecholamine Producing Tumors in Childhood. Puberty & Its Disorders. Turner Syndrome. Polycystic Ovary Syndrome & Hirsutism. Menstrual Disorders in Adolescents. Disorders of Sexual Differentiation. THYROID DISORDERS. Thyroid Disorders of Infancy. Hypothyroidism. Hyperthyroidism. Thyromegaly. Thyroid Nodules and Cancers in Children. DISORDERS OF CALCIUM & MINERAL METABOLISM. Calcium Disorders in Children. Neonatal Calcium. Phosphorus & Magnesium Disorders. Rickets & Osteoporosis. Syndromes with Brittle Bones, Hyperostotic Bone Diseases & Fibrous Dysplasia of Bone. MISCELLANEOUS DISORDERS. Abnormal Endocrine Test Results Due to Non-endocrine Conditions. Autoimmune Endocrinopathies. Multiple Endocrine Neoplasias. Endocrine Tumors. Disorders of Water Homeostasis. Endocrine Disorders after Cancer Therapy. SPECIAL CONSIDERATIONS & RESOURCES. Radiation Terrorism. Using the Web to Obtain Information on Genetic and Hormone Disorders. Hormonal Dynamic Tests & Genetic Tests Used in Pediatric Endocrinology

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Book SynopsisExtracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Addiction and the Medical Complications of Drug Abuse explores the physiological and psychological phenomenon of addiction including the nature of dependence, the dependence potential of drugs, and the importance of motivation. Contributions analyze the practice of substitute prescribing and detail the immediate and long term benefits of their use in maintenance or controlled withdrawal from opioids, stimulants, and benzodiazepines. It considers the use of methadone, buprenorphine, adrenergic agonists, and naltrexone for detoxification. Practitioners will benefit from the expert instruction on the management of common comorbidities, including diagnosis and pharmaceutical treatment of psychological disorders. Additional information covers the physiological effects of each drug and the emergency management of several drug related disordersTable of ContentsThe Principles of Addiction Medicine, Substitute Prescribing: Opioid-Specific Prescribing, Substitute Prescribing: Buprenorphine Maintenance Prescribing, Treatment of Withdrawal Symptoms, Replacement Prescribing, Management of Comorbidity’s, Toxicologic Issues, Medical Aspects of Drug Abuse, Emergency Management of Drug Abuse-Related Disorders

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Book SynopsisWritten by a team of leading authorities in pathogenesis, diagnostic techniques, and clinical management strategies in myelodysplastic syndrome (MDS), this text provides a concise, easy-to-follow review of the advances in the science, classification, diagnosis, and management of the condition. An ideal source for hematologists, oncologists, and cancer researchers, this Second Edition features: a new eight-page color insert 200 color and black-and-white illustrations reworked content organized into three sections: MDS epidemiology and biology; diagnosis, classification, and prognosis; and MDS therapy thoroughly updated chapters reflecting a shift from the topical focus as dictated by the evolution of the field New topics in Myelodysplastic Syndrome include: del(5q) and 5q-syndrome, CMML, and MDS-MPD overlap syndrome the reborn DNA meTable of Contents1. Myelodysplastic Syndrome: Historical Aspects and Classification. 2. Epidemiology of MDS. 3. Cytogenetics & Molecular Biology of MDS. 4. Global Genomic Approaches to MDS. 5. The Role of Apoptosis in MDS. 6. The Role of Mitochondria in MDS. 7. Defects in Iron Metabolism and Iron Overload in MDS. 8. Therapy-Related MDS and Myeloid Leukemia. 9. Diagnosis of MDS: Criteria and Challenges. 10. Hypocellular MDS and Hypocellulcar Acute Myeloid Leukemias: Relationship to Aplastic Anemia. 11. Diagnostic Utility of Flow Cytometry. 12. Deletion 5q and 5q-Syndrome in MDS. 13. CMML and MDS-MPD Overlap Syndromes. 14. MDS in Children. 15. Prognostic Factors in the Assessment of Patients with MDS. 16. Therapeutic Strategies: The Approsch to Care of Patients w/ MDS, and Criteria for Response. 17. Management of Cytopenias in MDS. 18. Immune Dysregulation And The Role For Immunotherapy in Myelodysplastic Syndrome (MDS). 19. Lenalidomide Therapy in MDS. 20. DNA Methyltransferase Inhibitor Therapy in MDS. 21. Intensive Chemotherapy and Stem Cell Transplantation in MDS.

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