Medical toxicology Books
Johns Hopkins University Press My House Is Killing Me
Book SynopsisWhether you have allergies or asthma, or you just want to avoid exposures to indoor contaminants and allergens, this book will teach you how to have a healthier home. In this thoroughly revised edition of My House Is Killing Me! Jeffrey C. and Connie L. May draw on the dramatic personal stories of their clients to help readers understand the links between indoor environmental conditions and human health. Explaining how air conditioning, finished basements, and other home features affect indoor air quality, the authors offer a step-by-step approach to identifying, controlling, and even eliminating the sources of indoor pollutants and allergens. This new edition includes more than 60 color photographs expanded coverage on the dangers posed by volatile organic compounds (VOCs) produced by such common items as paint, carpet, and household cleaning products up-to-date information on the potential risks of installing spray polyurethane foam (SPF) insulation completely new case studies of pTrade ReviewThe May's continue to be masterful storytellers, using their work with clients to help solve problems and increase education of their indoor spaces.—Healthy IndoorsTable of ContentsForeword, by Jonathan M. Samet, MD, and Elizabeth Matsui, MD, MHSAppreciationIntroduction Part I. The Stage of Our LivesChapter 1. Seeing the InvisibleChapter 2. Cast of Small Characters—Read This Chapter If You Dare!Chapter 3. "Trojan Horse" AllergensChapter 4. Creepy Crawlers (Apologies for the Title!)Chapter 5. The Three Ps—Pets, Pests, and PeopleChapter 6. The SetPart II. Daily LifeChapter 7. Living Rooms, Family Rooms, and Dining AreasChapter 8. Rooms with Water—The BathroomChapter 9. Rooms with Water—The KitchenChapter 10. Rooms with Water—The LaundryChapter 11. BedroomsChapter 12. Attached Garages, Bulkheads, Porches, and DecksChapter 13. The ExteriorChapter 14. Indoor Air Quality in Multi-Unit BuildingsPart III. Below and AboveChapter 15. Unfinished Basements and Crawl SpacesChapter 16. Finished BasementsChapter 17. AtticsPart IV. Heating and CoolingChapter 18. Heating and Cooling with DuctsChapter 19. Heating and Cooling without DuctsChapter 20. More on Heating, Cooling, and FuelPart V. Clean It Up—Inside and OutChapter 21. Renovation and New ConstructionChapter 22. More Environmental HazardsChapter 23. Testing and RemediationChapter 24. CleaningClosing Remarks: Take ChargeNotesGlossaryResource GuideIndex
£42.75
Johns Hopkins University Press My House Is Killing Me
Book SynopsisWhether you have allergies or asthma, or you just want to avoid exposures to indoor contaminants and allergens, this book will teach you how to have a healthier home. In this thoroughly revised edition of My House Is Killing Me! Jeffrey C. and Connie L. May draw on the dramatic personal stories of their clients to help readers understand the links between indoor environmental conditions and human health. Explaining how air conditioning, finished basements, and other home features affect indoor air quality, the authors offer a step-by-step approach to identifying, controlling, and even eliminating the sources of indoor pollutants and allergens. This new edition includes more than 60 color photographs expanded coverage on the dangers posed by volatile organic compounds (VOCs) produced by such common items as paint, carpet, and household cleaning products up-to-date information on the potential risks of installing spray polyurethane foam (SPF) insulation completely new case studies of pTrade ReviewThe May's continue to be masterful storytellers, using their work with clients to help solve problems and increase education of their indoor spaces.—Healthy IndoorsTable of ContentsForeword, by Jonathan M. Samet, MD, and Elizabeth Matsui, MD, MHSAppreciationIntroduction Part I. The Stage of Our LivesChapter 1. Seeing the InvisibleChapter 2. Cast of Small Characters—Read This Chapter If You Dare!Chapter 3. "Trojan Horse" AllergensChapter 4. Creepy Crawlers (Apologies for the Title!)Chapter 5. The Three Ps—Pets, Pests, and PeopleChapter 6. The SetPart II. Daily LifeChapter 7. Living Rooms, Family Rooms, and Dining AreasChapter 8. Rooms with Water—The BathroomChapter 9. Rooms with Water—The KitchenChapter 10. Rooms with Water—The LaundryChapter 11. BedroomsChapter 12. Attached Garages, Bulkheads, Porches, and DecksChapter 13. The ExteriorChapter 14. Indoor Air Quality in Multi-Unit BuildingsPart III. Below and AboveChapter 15. Unfinished Basements and Crawl SpacesChapter 16. Finished BasementsChapter 17. AtticsPart IV. Heating and CoolingChapter 18. Heating and Cooling with DuctsChapter 19. Heating and Cooling without DuctsChapter 20. More on Heating, Cooling, and FuelPart V. Clean It Up—Inside and OutChapter 21. Renovation and New ConstructionChapter 22. More Environmental HazardsChapter 23. Testing and RemediationChapter 24. CleaningClosing Remarks: Take ChargeNotesGlossaryResource GuideIndex
£19.47
Johns Hopkins University Press Toxic Exposure
Book SynopsisA behind-the-scenes look inside three key trials involving Monsanto's weed killer Roundup, cancer, and the search for justicewritten by an expert witness medical oncologist who lived it all. For years, Monsanto declared that their product Roundup, the world's most widely used weed killer, was safe. But that all changed in 2015, when the International Agency for Research on Cancer (IARC) analyzed data from scientific studies and concluded that glyphosate, the active ingredient in Roundup, is probably carcinogenic.The Environmental Protection Agency (EPA) disagreed, other regulatory agencies got involved, and scientists clamored to understand the link between glyphosate and cancer. Toxic Exposure tells the true story of numerous patients who developed non-Hodgkin lymphoma, a form of cancer, after using Roundup and their ensuing trials against Monsanto (now owned by Bayer, one of the largest agrochemical companies in the world). Written by Chadi Nabhan, MD, MBA, a cancer specialist, tTrade ReviewThe author describes keeping his compassion for patients front and center despite tough grilling by Monsanto's lawyers and sharpening his resolve by remembering that he was there to help ameliorate suffering.Readers are invited along for the ride: sweating on the witness stand, hanging on the lawyers' every word, hoping for the truth to prevail.—Civil EatsTable of ContentsAuthor's NotePrefaceChapter 1. The Phone CallChapter 2. The First MeetingChapter 3. The EPAChapter 4. Meeting Mr. JohnsonChapter 5. The Night Before the Daubert HearingChapter 6. Coming to AmericaChapter 7. Daubert DayChapter 8. The Johnson Trial BeginsChapter 9. My Trial TestimonyChapter 10. The Johnson VerdictChapter 11. HardemanChapter 12. The Second Trial BeginsChapter 13. VerdictsChapter 14. PilliodsChapter 15. The Third Trial BeginsChapter 16. Another Day in CourtChapter 17. JudgmentChapter 18. EndingsGlossaryResourcesAcknowledgments
£22.50
Duke University Press Infertile Environments Epigenetic Toxicology and
Book SynopsisDrawing on fieldwork in a Chinese toxicology lab that studies the influence of toxins on male reproductive and developmental health, Janelle Lamoreaux investigates how epigenetic research conceptualizes and configures environments.Table of ContentsPreface ix Acknowledgments xv Introduction 1 1. The National Environment 21 2. The Hormonal Environment 35 3. The Dietary Environment 52 4. The Maternal Environment 64 5. The Laboratory Environment 77 Coda 92 Epilogue 97 Notes 103 References 109 Index 129
£62.90
Duke University Press Infertile Environments
Book SynopsisDrawing on fieldwork in a Chinese toxicology lab that studies the influence of toxins on male reproductive and developmental health, Janelle Lamoreaux investigates how epigenetic research conceptualizes and configures environments.Table of ContentsPreface ix Acknowledgments xv Introduction 1 1. The National Environment 21 2. The Hormonal Environment 35 3. The Dietary Environment 52 4. The Maternal Environment 64 5. The Laboratory Environment 77 Coda 92 Epilogue 97 Notes 103 References 109 Index 129
£18.04
University Press of Mississippi Scorpions of Medical Importance
Book SynopsisThis publication is an account of the distribution, morphology, biology and classification of those scorpions considered to be of medical importance. The book also contains information on the clinical aspects of scorpion envenomation, and on methods for scorpion control.Though the scope of this book is clearly delineated by its title, Scorpions of Medical Importance, Professor Keegan does consider those genera and species of scorpions that are not of medical importance, but commonly occur in association with man, and are often greatly feared. He has done so because of the scorpion's potential as a stimulus for entomophobia. While this fear, created in part by folklore, dramatic but inaccurate literature, and television and motion picture sequences, is useful in areas where dangerously venomous scorpions exist, it has also created much needless apprehension. It will surely be a revelation to many readers that of approximately 800 species that have been described, only about 50 have been reported as being dangerous to man.A valuable feature of Scorpions of Medical Importance is the outstanding drawings that have been used to illustrate the species. It is not often that one comes across drawings so striking in their precision and attention to even the most minute details.As one of the very few books dealing solely with the general subject of scorpions of medical importance, this publication should be a useful reference for all of those interested in the distribution, biology, and control of dangerously venomous scorpions, and in clinical aspects of scorpion envenomation.The book also contains an index, bibliography, and pertinent references to related species not discussed in the book.
£22.46
CABI Publishing Nematodes as Model Organisms
Book SynopsisNematodes are small multicellular organisms that have been used as biological models since the 1960s. For example, Caenorhabditis elegans is a free-living nematode worm, about 1mm in length, that lives in temperate soil environments. It is made up of about 1000 cells, and has a short life cycle of only two weeks. It was the first multicellular organism to have its whole genome sequenced. The book summarizes the importance of nematodes as model organisms in the fields of genetics, developmental biology, neurobiology, pharmacology, nutrition, ecology and parasitology. Of interest to a broad audience across a wide spectrum of disciplines, this book is useful for biologists working on comparative studies to investigate biological processes across organisms; medical scientists and pharmacologists for exploration of drugs and medicine (including the use of genome editing to eliminate diseases); ecologists considering nematodes as indicators for environment changes; and parasitologists for host-parasite interactions. Many other researchers can use this book as a benchmark for the broad implications of nematology research on other aspects of science.Table of ContentsPart 1: Biological Systems Chapter 1: The genus Pristionchus: a model for phenotypic plasticity, predatory behavior, self-recognition and other complex traits Chapter 2: Aging Chapter 3: Entomopathogenic nematodes as a model for probing the insect immune system Chapter 4: The use of the root-knot nematodes, Meloidogyne spp., for studying biotrophic parasitic interactions Chapter 5: Nematodes as a model for symbiosis Chapter 6: Nematode pharmacology: neurotransmitters, receptors and experimental approaches Part 2: Ecology and Toxicology Chapter 7: Nematodes as ecological and environmental Indicators Chapter 8: Use in soil agro-ecology Chapter 9: Stress and survival mechanisms Chapter 10: Molecular toxicology in Caenorhabditis elegans Chapter 11: Nematode use for testing theoretical models of behavioral ecology Chapter 12: Entomopathogenic nematodes as models For inundative biological control Chapter 13: Parasitic nematodes and their symbiosis with bacteria: model systems for studying parasitism and pathogenesis Chapter 14: Genetic improvement of beneficial organisms
£88.92
Springer Nature Switzerland AG Toxicology of Organophosphate Poisoning: New
Book SynopsisThis book addresses the consequences of high agricultural pesticide use over the last few decades in the form of organophosphate poisoning. The authors provide a background overview of organophosphate compounds, their environmental toxicity, non-target exposures and cases of human poisoning. The authors also compile and analyze data from the last two decades to demonstrate the toxicological aspects of organophosphates, and how they can pose a threat to human health. Readers will learn about the clinical manifestation of organophosphate exposure in humans, as well as the enzymatic pathways and mechanisms by which organophosphates are processed in the body and cause harm. The book concludes by providing techniques, practices and recommendations for how to manage organophosphate exposure and poisoning. It will be useful for clinicians and public health professionals, scientists, medical practitioners, researchers and environmental toxicologists. Table of ContentsChapter 1: Overview of organophosphate compounds.- Chapter 2: Toxicology of Organophosphate poisoning in humans.- Chapter 3: Enzymatic Targets of organophosphates.- Chapter 4: Computational insights of human acetylcholinesterase inhibition.- Chapter 5: New insights in Prophylactic approaches of human poisoning.- Chapter 6: Management of human Organophosphate poisoning.- Chapter 7: Summary.
£104.49
Springer Nature Switzerland AG Nanotoxicology in Humans and the Environment
Book SynopsisThe book covers the area of ‘Nanotoxicology’ but primarily from the point of view of nanotoxicology at the interface with other disciplines including human toxicology; environmental toxicology; characterization, dose and transformations; regulation; public and elite group perceptions; and interactions with innovation.Nanotoxicology in Humans and the Environment is written for researchers in nanotoxicology in academia, industry, government, and research students. Given the rapid development, the maturing of the discipline and its importance in current regulation and industry development (eg REACH, TSCA), the book is very timely.Table of ContentsChapter 1 Overview of nanotoxicology in humans and the environment; developments, challenges and impacts Stephen J. Evans, Paul M. Vecchiarelli, Martin J. D. Clift, Shareen H. Doak, Jamie R. Lead, Chapter 2 The potential adverse effects of engineered nanomaterial exposure to human health following pulmonary, oral and dermal exposure Ali Kermanizadeh, Flemming R. Cassee & Wim de Jong Chapter 3 Nanotoxicology in the environment Yueyang Zhang and Greg Goss, University of Alberta Chapter 4 Nano-enabled consumer products – inventories, release, and exposures. SF Hansen, A Makevica, MS Hull Chapter 5 Factors affecting nanoparticle dose–exposure and cell response Sandor Balog, Barbara Rothen-Rutishauser, and Alke Petri-Fink Chapter 6 Mapping Exposure onto Nanoscale Toxicity Measures D. Vallero, Duke University Chapter 7 Nanotoxicology and risk perception among public and elite groups Barbara Herr Harthorn, Terre Satterfield, Nick Pidgeon Chapter 8 EU Regulations and Nanotechnology Innovation.
£108.17
Springer Nanotechnology
Book SynopsisGreen-synthesized nanoparticles and their ecotoxicity in aquatic organisms.- Nanotechnology to mitigate toxicology effect on aquatic biota and human life.- Green Nanomaterials for Environmental Mitigation.- Nanoinsecticides: Nanomaterials to Combat Insects.- Development of Nanoparticles for use in Immunotherapy. Nanoimmunomodulators (NIM).- Nano-based bioinks for Biomedical Applications.- Nanomaterials for Capturing and Storing CO2: A Sequestration Approach.- Gas Sensing Application of Nanomaterials.- Nanomaterials for water splitting and hydrogen generation.- Integrating Nanoscience in the Realm of Renewable Energy.- Revolutionizing Water Purification through Nanotechnology.- Nano-Based Adsorbents for Wastewater Treatment.- Nano Based Green Adsorbent for Treatment of Waste Water.- Carbon Nanostructures for Nanoremediation Technology.- Carbon Nanostructures for Nanoremediation Technology.- An Insight into Recent Advances in Nanocatalysts for Photodegradation of Organic and Inorganic Pollutants.
£116.99
De Gruyter Natural Poisons and Venoms: Animal Toxins
Book SynopsisThis book series is based on the book "Biogene Gifte", 3. Edition, published 2010 by Wissenschaftliche Verlagsgesellschaft Stuttgart in German language. Because of the enormous increase in knowledge in the field of natural poisons and venoms the topic is now covered in 5 volumes in English language. The focus of this volume is on the toxic ingredients of animal poisons and venoms, their chemical structures, their effects and modes of actions in target organisms, and on the biology of poisonous or venomous animals. It highlights the symptoms of poisoning or envenoming in humans or animals, cite case reports were available, and gives hints on poisoning prevention and on potential treatments.
£58.65
Springer Verlag, Singapore Toxicology and Human Health: Environmental Exposures and Biomarkers
Book SynopsisThis contributed volume brings out a comprehensive collection of information on environmental toxicology, its impact on living organisms in general and human health in particular. The main focus of this book is to address human health issues and risk assessment. Toxicological studies help in understanding the impact of harmful substances including both natural and synthetic chemicals on organisms and their environment. Contributions in the title include both laboratory and field based studies with a focus on human health. Moreover, day by day, there is an increase in the range of chemicals from pharmaceutical and other industries, agricultural runoffs, medicine, and many other sources which continuously contribute to the earth's chemical load. Almost all the countries are facing great difficulties in responding to the crucial and immediate need for effective management of such contaminants. The title compiles studies in regards to environmental toxicology and its effect on human health. This book provides critical information and knowledge that can be used by regulatory agencies, decision-makers, policy makers, graduate and post-graduate students, researchers, environmental toxicologists, etc, and others to put programs and policies in place to limit our exposures to these substances thereby preventing or reducing the likelihood that a disease or other negative health outcomes would occur.Table of ContentsAttached
£116.99
£39.99
Taylor & Francis Ltd Total Exposure Health An Introduction Environmental and Occupational Health Series
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£128.25
Taylor & Francis Ltd Jet Fuel Toxicology
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£58.89
Taylor & Francis Ltd Cardiovascular Toxicology Target Organ Toxicology
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£56.99
Taylor & Francis Ltd Toxicology and Regulatory Process
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£58.89
Taylor & Francis Ltd Air Pollutants and the Respiratory Tract
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£56.99
Taylor & Francis Ltd Reviews in Food and Nutrition Toxicity Volume 2
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£58.89
Taylor & Francis Ltd Carbon Monoxide Toxicity
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£58.89
Taylor & Francis Ltd Principles Of Clinical Toxicology
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£56.99
Taylor & Francis Ltd Genetically Engineered Toxins
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£41.99
Taylor & Francis Ltd Synthetic Pesticide Use in Africa
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£175.75
Taylor & Francis Ltd Guide to Cytochromes P450
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£58.89
Taylor & Francis Ltd Ophthalmic Toxicology
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£56.04
Taylor & Francis Ltd Principles of Cardiac Toxicology
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Taylor & Francis Ltd Statistics for Toxicologists
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Taylor & Francis Ltd Depleted Uranium Properties Uses and Health Consequences
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£56.04
Taylor & Francis Ltd Reviews in Food and Nutrition Toxicity Volume 4 04
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£56.04
Taylor & Francis Ltd Control of Foodborne Microorganisms World of Work
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£56.04
Taylor & Francis Ltd Target Organ Toxicity in Marine and Freshwater Teleosts Organs New Perspectives Toxicology and the Environment
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£56.04
Taylor & Francis Ltd Ibuprofen A Critical Bibliographic Review
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£56.04
Taylor & Francis Ltd Biotechnology And Safety Assessment
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Taylor & Francis Ltd Total Exposure Health
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£47.49
Taylor & Francis Ltd The Charnoly Body
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£43.69
Taylor & Francis Kingship and Masculinity in Late Medieval England
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£37.99
Taylor & Francis Kingship and Masculinity in Late Medieval England
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£137.75
Taylor & Francis StateLed Privatization in China
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£142.50
Taylor & Francis Ltd Toxicology of the Human Environment The Critical Role of Free Radicals
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£166.25
Taylor & Francis Analytical and Practical Aspects of Drug Testing in Hair
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£175.75
Taylor & Francis Ltd The Toxic Microbiome
Book SynopsisGut microbiomes are dynamic communities varying from population to population and throughout life. In Western societies, a toxic metabolic shift of gut microbiomes is a driver and underestimated risk factor for the development of many noncommunicable chronic pathologies. This book identifies the root cause of these deleterious microbial changes. During the last several decades, increased consumption of animal products, coinciding and correlating with global climate change, has been a contributing cause of undesirable gut microbiome changes.Key Features Establishes a connection between poor gut microbiome health and chronic disease and cancer development Demonstrates how animal products and low-fiber diet patterns induce a detrimental metabolic transition of the gut microbiome from a human health-maintaining towards a disease-promoting state Discusses the opportunity of a toxic microbial metabolic signatTable of ContentsTable of Contents Dedication Preface Introduction Chapter 1: Diet related chronic diseases are the most critical health problem of modern societies – how did that happen? Chapter 2: The "industrialized" microbiome - a caution label for a global epidemic Missing microbes - does it matter? Chapter 3: The subtle problems of microbiome research Is the microbiome "oversold"? Is microbiome science heading in the wrong direction? Chapter 4: The gut microbiome: a new perspective Our microbiome is a metabolic organ Functional omes: metabolites over species Finding a new definition for a "healthy" microbiome and "dysbiosis" Chapter 5: Shaping the microbial behavior Diet: the master educator of the gut microbiome Starving the microbial self: a foundation for developing a chronic disease Chapter 6: The toxic microbiome "It’s not the fiber, it’s the animal protein" Protein fermentation Fat toxicity Secondary bile acids Heme iron TMAO: the way to a man’s heart is through his gut microbiota Toxicomicrobiomics A toxic microbiome: useful for predicting chronic diseases? Chapter 7: How to build a healthy gut microbiome and prevent chronic diseases The "true" human diet: are humans really omnivores? "The Paleo diet is a myth" Protein concerns: Do we get enough on plants? Feeding microbes for disease prevention and treatment Chapter 8: "Fixing" the microbiome - Can we restore a healthy microbiome by other means than diet? Probiotics – hype or hope? Fecal microbial transplantation or "The Power of Poop" The "Wild West" of microbiome science: drugging the microbiome and personalized nutrition Glossary Abbreviations Literature
£39.99
Cambridge University Press Supplementary Mutagenicity Tests
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£24.99
Elsevier Science Publishing Co Inc Biomarkers in Toxicology
Book SynopsisTable of ContentsPart I. Toxicity Testing Models and Biomarkers1. Introduction2. Rodent Models for Toxicity Testing and Biomarkers3. The Göttingen Minipig as large animal model in toxicology4. Nonhuman primates in preclinical research5. Biomarkers of toxicity in zebrafish6. Mechanistic Toxicology Biomarkers in Caenorhabditis elegans7. Drosophila melanogaster, Eisenia fetida, and Daphnia magna for toxicity testing and Biomarkers 8. Alternative animal toxicity testing and biomarkers9. Adverse outcome pathways and biomarkers Part II. Systems Toxicity Biomarkers10. Central nervous system toxicity biomarkers11. Peripheral nervous system toxicity biomarkers12. Cardiovascular toxicity biomarkers13. Respiratory toxicity biomarkers14. Hepatic toxicity biomarkers15. Conventional and emerging renal biomarkers16. Gastrointestinal toxicity biomarkers17. Reproductive toxicity biomarkers18. Biomarkers of toxicity in human placenta19. Early Biomarkers of Acute and Chronic Pancreatitis20. Skeletal muscle toxicity biomarkers21. Ocular biomarkers in diseases and toxicities22. Biomarkers of Ototoxicity23. Blood and bone marrow toxicity biomarkers24. Immunotoxicity biomarkers Part III. Chemical Agents, Solvents and Gases Toxicity Biomarkers25. Bisphenol A (BPA) Biomarkers and Biomonitoring26. Insecticides27. Herbicides and fungicides28. Polychlorinated biphenyls, polybrominated biphenyls, and brominated flame retardants29. Polycyclic aromatic hydrocarbons30. Metals31. Melamine 32. Biomarkers of petroleum products toxicity 33. Biomarkers of chemical mixture toxicity34. Biomarkers of toxic solvents and gases Part IV. Biotoxins Biomarkers35. Freshwater cyanotoxins 36. Mycotoxins37. Poisonous plants: biomarkers for diagnosis Part V. Pharmaceuticals and Nutraceuticals Biomarkers38. Biomarkers of drug toxicity and safety evaluation 39. Risk Assessment, Regulation and the Role of Biomarkers for the Evaluation of Dietary Ingredients present in Dietary Supplements40. Nutriphenomics in rodent models: Impact of dietary choices on toxicological biomarkers Part VI. Nanomaterials and Radiation41. Engineered nanomaterials: Biomarkers of exposure and effect42. Biomarkers of Exposure and Responses to Ionizing Radiation Part VII. Carcinogens Biomonitoring and Cancer Biomarkers43. Biomonitoring exposures to carcinogens44. Genotoxicity biomarkers: Molecular basis of genetic variability and susceptibility45. Epigenetic biomarkers in toxicology46. Breast cancer biomarkers47. Pancreatic and ovarian cancer biomarkers48. Prostate cancer biomarkers Part VIII. Disease Biomarkers49. Biomarkers of Alzheimer’s disease50. Biomarkers of Parkinson’s disease51. Biomarkers for drugs of abuse and neuropsychiatric disorders: Models and mechanisms52. Osteoarthritis biomarkers53. Pathological biomarkers in toxicology54. Oral pathology biomarkers Part IX. Special Topics55. Biomarkers of mitochondrial dysfunction and toxicity 56. Biomarkers of blood-brain barrier dysfunction57. Biomarkers of oxidative/nitrosative stress and neurotoxicity58. Cytoskeletal disruption as a biomarker of developmental neurotoxicity59. Membrane transporters and transporter substrates as biomarkers for drug pharmacokinetics, pharmacodynamics, and toxicity/adverse events60. Citrulline: Pharmacological perspectives and role as a biomarker in diseases and toxicities Part X. Applications of Biomarkers in Toxicology61. Analysis of toxin- and toxicant-induced biomarker signatures using microarrays62. Biomarkers detection for toxicity testing using metabolomics63. Transcriptomic biomarkers in safety and risk assessment of chemicals64. Percellome toxicogenomics project as a source of biomarkers of chemical toxicity65. Proteomics in biomarkers of chemical toxicity66. Biomarkers for Testing Toxicity and Monitoring Exposure to Xenobiotics67. Biomarkers in epidemiology, risk assessment and regulatory toxicology
£215.00
The University of Chicago Press Choked
Book Synopsis
£28.50
Little Brown and Company Most Delicious Poison
Book Synopsis
£14.05
Johns Hopkins University Press The Mold Survival Guide
Book SynopsisWith clear scientific explanations and expert advice, The Mold Survival Guide is a valuable resource for anyone worried about a common household problem that can have serious consequences.Trade ReviewWhat molds are, why and where they grow, and how to rid our living spaces of these dangerous fungal microorganisms. The authors furnish clear explanations, examples from actual situations, and valuable advice... A storehouse of knowledge presented in a readable style. Library Journal Mold is a hot issue today, but the problem dates back to biblical times. Jeffrey May, author of My House is Killing Me, is a recognized authority on indoor pollution who focuses here on mold-how it prospers, how it affects one's health, and how it can be remediated. Science News Their handbook delivers both scientific explanations and expert advice. The most common problems can be headed off or corrected once the homeowner understands the life cycle of mold. That alone is worth the price of the book. Boston Globe Magazine A good job on a subject most of us would find less than stimulating... Were I actively listing and selling homes, I would keep this book handy as a reference and I would take every opportunity to see how the issue is playing out at the local level. Home inspectors would obviously be a great source of information, both academic and practical. -- Dr. Kenneth W. Edwards Real Estate Professional 2004 The Mold Survival Guide details mold problems and eradication methods and includes photographs-some in color-that show what water damage and mold infestation look like. -- Jim Watkins Washington Times Mold. It's a scary, mystifying and shudder inducing word... The Mays explore what mold is, where and why it grows, how it flourishes, and how it may or may not cause health problems. Readers learn how to identify mold, how to prevent it from spreading and when to call an expert. Baltimore Sun Recommended particularly for concerned homeowners and renovation architects, The Mold Survival Guide: For Your Home and for Your Health outlines the causes of moisture problems in old and new buildings... Leading you through his most tried-and-true forensic methodologies, Jeff May gives you the tools to root out the causes of the bedeviling musty odors that have forced homeowners to flee their homes. -- Courtney Miller ArchitectureBoston This book will help you make sensible decisions and cut through the 'fear factor' language in a lot of advertising. -- Holly Hayes San Jose Mercury NewsTable of ContentsPrefaceAcknowledgementsPart I: The World of MoldChapter 1. The Indispensable Kingdom of FungiChapter 2. Watering Mold and Spreading SporesChapter 3. How Mold Affects Our HealthChapter 4. Mold Wages Battle: Then and NowPart II: The Search For MoldChapter 5. What Lurks BelowChapter 6. Mold in the MechanicalsChapter 7. The Spaces We Live InChapter 8. The Spaces We Don't Live InChapter 9. Testing for MoldPart III: The CleanupChapter 10. Small-Scale Cleanup JobsChapter 11. Professional RemediationConclusionResource GuideIndex
£25.64
Brigham Young University Press On Poisons and the Protection against Lethal
Book SynopsisWritten in 1199 at the request of al-Qadi al-Fadil, the famous counselor and secretary to Saladin, On Poisons and the Protection against Lethal Drugs is distinguished rabbi Moses Maimonides' guide to emergency first aid and readily available antidotes. This book includes critical editions of the medieval Hebrew and Latin translations.
£999.99
John Wiley & Sons Inc Stem Cells in Toxicology and Medicine
Book SynopsisA comprehensive and authoritative compilation of up-to-date developments in stem cell research and its use in toxicology and medicine Presented by internationally recognized investigators in this exciting field of scientific researchProvides an insight into the current trends and future directions of research in this rapidly developing new fieldA valuable and excellent source of authoritative and up-to-date information for researchers, toxicologists, drug industry, risk assessors and regulators in academia, industry and governmentTable of ContentsList of Contributors xx Preface xxvi Acknowledgements xxvii PART I 1 1 Introduction 3 Saura C. Sahu References 4 2 Application of Stem Cells and iPS Cells in Toxicology 5 Maria Virginia Caballero, Ramon A. Espinoza‐Lewis, and Manila Candiracci 2.1 Introduction 5 2.2 Significance 6 2.3 Stem Cell (SC) Classification 7 2.4 Stem Cells and Pharmacotoxicological Screenings 8 2.5 Industrial Utilization Showcases Stem Cell Technology as a Research Tool 8 2.6 Multipotent Stem Cells (Adult Stem Cells) Characteristics and Current Uses 9 2.7 Mesenchymal Stem Cells (Adult Stem Cells) 10 2.8 Hematopoietic Stem Cells (Adult Stem Cells) 11 2.9 Cardiotoxicity 12 2.10 Hepatotoxicity 15 2.11 Epigenetic Profile 17 2.12 Use of SC and iPSC in Drug Safety 18 2.13 Conclusions and Future Applications 19 Acknowledgments 19 References 19 3 Stem Cells: A Potential Source for High Throughput Screening in Toxicology 26 Harish K Handral, Gopu Sriram, and Tong Cao 3.1 Introduction 26 3.2 Stem Cells 27 3.3 High Throughput Screening (HTS) 31 3.4 Need for a Stem Cell Approach in High Throughput Toxicity Studies 37 3.5 Role of Stem Cells in High Throughput Screening for Toxicity Prediction 38 3.6 Conclusion 40 Acknowledgement 41 Disclosure Statement 41 Author’s Contribution 41 References 41 4 Human Pluripotent Stem Cells for Toxicological Screening 50 Lili Du and Dunjin Chen 4.1 Introduction 50 4.2 The Biological Characteristics of hPSCs 51 4.3 Screening of Embryotoxic Effects using hPSCs 52 4.4 The Potential of hPSC‐Derived Neural Lineages in Neurotoxicology 55 4.5 The Potential of hPSC ‐Derived Cardiomyocytes in Cardiotoxicity 60 4.6 The Potential of hPSC‐Derived Hepatocytes in Hepatotoxicity 62 4.7 Future Challenges and Perspectives for Embryotoxicity and Developmental Toxicity Studies using hPSCs 65 Acknowledgments 66 References 67 5 Effects of Culture Conditions on Maturation of Stem Cell‐Derived Cardiomyocytes 71 Deborah K. Hansen, Amy L. Inselman, and Xi Yang 5.1 Introduction 71 5.2 Lengthening Culture Time 75 5.3 Substrate Stiffness 76 5.4 Structured Substrates 78 5.5 Conclusions 82 Disclaimer 82 References 83 6 Human Stem Cell‐Derived Cardiomyocyte In Vitro Models for Cardiotoxicity Screening 85 Tracy Walker, Kate Harris, Evie Maifoshie, and Khuram Chaudhary 6.1 Introduction 85 6.2 Overview of hPSC‐Derived Cardiomyocytes 88 6.3 Human PSC‐CM Models for Cardiotoxicity Investigations 90 6.4 Conclusions and Future Direction 112 References 112 7 Disease‐Specific Stem Cell Models for Toxicological Screenings and Drug Development 122 Matthias Jung, Juliane‐Susanne Jung, Jovita Schiller, and Insa S. Schroeder 7.1 Evidence for Stem Cell‐Based Drug Development and Toxicological Screenings in Psychiatric Diseases, Cardiovascular Diseases and Diabetes 122 7.2 Disease‐Specific Stem Cell Models for Drug Development in Psychiatric Disorders 127 7.3 Stem Cell Models for Cardiotoxicity and Cardiovascular Disorders 132 7.4 Stem Cell Models for Toxicological Screenings of EDCs 133 References 135 8 Three‐Dimensional Culture Systems and Humanized Liver Models Using Hepatic Stem Cells for Enhanced Toxicity Assessment 145 Ran‐Ran Zhang, Yun‐Wen Zheng, and Hideki Taniguchi 8.1 Introduction 145 8.2 Hepatic Cell Lines and Primary Human Hepatocytes 146 8.3 Embryonic Stem Cells and Induced Pluripotent Stem‐Cell Derived Hepatocytes 147 8.4 Ex Vivo: Three‐Dimensional and Multiple‐Cell Culture System 148 8.5 In Vivo: Humanized Liver Models 149 8.6 Summary 150 Acknowledgments 150 References 150 9 Utilization of In Vitro Neurotoxicity Models in Pre‐Clinical Toxicity Assessment 155 Karin Staflin, Dinah Misner, and Donna Dambach 9.1 Introduction 155 9.2 Current Models of Drug‐Related Clinical Neuropathies and Effects on Electrophysiological Function 159 9.3 Cell Types that Can Potentially Be Used for In Vitro Neurotoxicity Assessment in Drug Development 162 9.4 Utility of iPSC Derived Neurons in In Vitro Safety Assessment 167 9.5 Summary of Key Points for Consideration in Neurotoxicity Assay Development 170 9.6 Concluding Remarks 172 References 172 10 A Human Stem Cell Model for Creating Placental Syncytiotrophoblast, the Major Cellular Barrier that Limits Fetal Exposure to Xenobiotics 179 R. Michael Roberts, Shinichiro Yabe, Ying Yang, and Toshihiko Ezashi 10.1 Introduction 179 10.2 General Features of Placental Structure 180 10.3 The Human Placenta 180 10.4 Human Placental Cells in Toxicology Research 182 10.5 Placental Trophoblast Derived from hESC 183 10.6 Isolation of Syncytial Areas from BAP‐Treated H1 ESC Colonies 185 10.7 Developmental Regulation of Genes Encoding Proteins Potentially Involved in Metabolism of Xenobiotics 185 10.8 Concluding Remarks 191 Acknowledgments 192 References 192 11 The Effects of Endocrine Disruptors on Mesenchymal Stem Cells 196 Marjorie E. Bateman, Amy L. Strong, John McLachlan, Matthew E. Burow, and Bruce A. Bunnell 11.1 Mesenchymal Stem Cells 196 11.2 Endocrine Disruptors 198 11.3 Pesticides 201 11.4 Alkyl Phenols and Derivatives 206 11.5 Bisphenol A 211 11.6 Polychlorinated Biphenyls 216 11.7 Phthalates 221 11.8 Areas for Future Research 225 11.9 Conclusions 226 Abbreviations 226 References 228 12 Epigenetic Landscape in Embryonic Stem Cells 238 Xiaonan Sun, Nicholas Spellmon, Joshua Holcomb, Wen Xue, Chunying Li, and Zhe Yang 12.1 Introduction 238 12.2 DNA Methylation in ESCs 239 12.3 Histone Methylation in ESCs 240 12.4 Chromatin Remodeling and ESCs Regulation 241 12.5 Concluding Remarks 242 Acknowledgements 243 References 243 PART II 247 13 The Effect of Human Pluripotent Stem Cell Platforms on Preclinical Drug Development 249 Kevin G. Chen 13.1 Introduction 249 13.2 Core Signaling Pathways Underlying hPSC Stemness and Differentiation 250 13.3 Basic Components of In Vitro and Ex Vivo hPSC Platforms 251 13.4 Diverse hPSC Culture Platforms for Drug Discovery 252 13.5 Representative Analyses of hPSC‐Based Drug Discovery 255 13.6 Current Challenges and Future Considerations 257 13.7 Concluding Remarks 260 Acknowledgments 260 References 260 14 Generation and Application of 3D Culture Systems in Human Drug Discovery and Medicine 265 H. Rashidi and D.C. Hay 14.1 Introduction 265 14.2 Traditional Scaffold‐Based Tissue Engineering 266 14.3 Scaffold‐Free 3D Culture Systems 269 14.4 Modular Biofabrication 270 14.5 3D Bioprinting 270 14.6 Tissue Modelling and Regenerative Medicine Applications of Pluripotent Stem Cells 272 14.7 Applications in Drug Discovery and Toxicity 275 14.8 Conclusions 278 References 278 15 Characterization and Therapeutic Uses of Adult Mesenchymal Stem Cells 288 Juliann G. Kiang 15.1 Introduction 288 15.2 MSC Characterization 289 15.3 MSCs and Tissue or Organ Therapy 293 15.4 Conclusions 298 Acknowledgments 298 References 298 16 Stem Cell Therapeutics for Cardiovascular Diseases 303 Yuning Hou, Xiaoqing Guan, Shukkur M. Farooq, Xiaonan Sun, Peijun Wang, Zhe Yang, and Chunying Li 16.1 Introduction 303 16.2 Types of Stem/Progenitor Cell‐Derived Endothelial Cells 304 16.3 EPC and Other Stem/Progenitor Cell Therapy in CVDs 306 16.4 Strategies and Approaches for Enhancing EPC Therapy in CVDs 306 16.5 Concluding Remarks 315 Acknowledgments 316 References 316 17 Stem‐Cell‐Based Therapies for Vascular Regeneration in Peripheral Artery Diseases 324 David M Smadja and Jean‐Sébastien Silvestre 17.1 Sources of Stem Cells for Vascular Regeneration 325 17.2 Canonic Mechanisms Governing Vascular Stem Cells Therapeutic Potential 329 17.3 Stem‐Cell‐Based Therapies in Patients with Peripheral Artery Disease 333 References 337 18 Gene Modified Stem/Progenitor‐Cell Therapy for Ischemic Stroke 347 Yaning Li, Guo‐Yuan Yang, and Yongting Wang 18.1 Introduction 347 18.2 Gene Modified Stem Cells for Ischemic Stroke 348 18.3 Gene Transfer Vectors 354 18.4 Unsolved Issues for Gene‐Modified Stem Cells in Ischemic Stroke 356 18.5 Conclusion 356 Abbreviations 356 Acknowledgments 357 References 357 19 Role of Stem Cells in the Gastrointestinal Tract and in the Development of Cancer 363 Pengyu Huang, Bin Li, and Yun‐Wen Zheng 19.1 Introduction 363 19.2 GI Development and Regeneration 365 19.3 GI Tumorigenesis and Stemness Gene Expression 367 19.4 Toxicants and Other Stress Trigger Epigenetic Changes, Dedifferentiation, and Carcinogenesis 368 19.5 Summary and Perspective 369 Acknowledgments 369 References 370 20 Cancer Stem Cells: Concept, Significance, and Management 375 Haseeb Zubair, Shafquat Azim, Sanjeev K. Srivastava, Arun Bhardwaj, Saravanakumar Marimuthu, Mary C. Patton, Seema Singh, and Ajay P. Singh 20.1 Introduction 375 20.2 Stem Cells and Cancer: Historical Perspective 376 20.3 Cancer Stem Cells 377 20.4 Identification and Isolation of CSCs 382 20.5 Pathological Significance of Cancer Stem Cells 388 20.6 Pathways Regulating Cancer Stem Cells 389 20.7 Therapeutic Strategies Targeting Cancer Stem Cells 394 20.8 Conclusion and Future Directions 399 References 400 21 Stem Cell Signaling in the Heterogeneous Development of Medulloblastoma 414 Joanna Triscott and Sandra E. Dunn 21.1 Brain Tumor Cancer Stem Cells 414 21.2 Medulloblastoma 416 21.3 Hijacking Cerebellar Development 417 21.4 Molecular Classification of MB 420 21.5 Mouse Models and Cell of Origin 424 21.6 Additional Drivers of MB 425 21.7 Repurposing Off‐Patent Drugs 426 21.8 Emerging Therapies for MB 428 21.9 Conclusion 429 Acknowledgments 429 References 429 22 Induced Pluripotent Stem Cell‐Derived Outer-Blood‐Retinal Barrier for Disease Modeling and Drug Discovery 436 Jun Jeon, Nathan Hotaling, and Kapil Bharti 22.1 Introduction 436 22.2 The Outer Blood‐Retinal Barrier 437 22.3 iPSC‐Based Model of the Outer-Blood‐Retinal-Barrier 439 22.4 iPSC Based OBRB Disease Models 442 22.5 Applications of iPSC‐Based Ocular Disease Models for Drug Discovery 448 22.6 Conclusion and Future Directions 451 References 451 23 Important Considerations in the Therapeutic Application of Stem Cells in Bone Healing and Regeneration 458 Hoda Elkhenany, Shawn Bourdo, Alexandru Biris, David Anderson, and Madhu Dhar 23.1 Introduction 458 23.2 Stem Cells, Progenitor Cells, Mesenchymal Stem Cells 459 23.3 Scaffolds 461 23.4 Animal Models in Bone Healing and Regeneration 464 23.5 Conclusions and Future Directions 472 References 472 24 Stem Cells from Human Dental Tissue for Regenerative Medicine 481 Junjun Liu and Shangfeng Liu 24.1 Introduction 481 24.2 Dental Stem Cells 482 24.3 Potential Clinical Applications 488 24.4 Safety 492 24.5 Dental Stem Cell Banking 493 24.6 Conclusions and Perspective 494 References 495 25 Stem Cells in the Skin 502 Hongwei Wang, Zhonglan Su, Shiyu Song, Ting Su, Mengyuan Niu, Yaqi Sun, and Hui Xu 25.1 Introduction 502 25.2 Stem Cells in the Skin 503 25.3 Isolation and the Biological Markers of Skin Stem Cells 506 25.4 Skin Stem Cell Niches 508 25.5 Signaling Control of Stem Cell Differentiation 510 25.6 Stem Cells in Skin Aging 514 25.7 Stem Cells in Skin Cancer 516 25.8 Medical Applications of Skin Stem Cells 518 25.9 Conclusions and Future Directions 520 References 521 Author Index 527 Subject Index 529
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