Medical diagnosis Books

Book SynopsisSelected as a Doody's Core Title for 2022!Continuing a legacy of excellence that spans nearly five decades, Bates’ Nursing Guide to Physical Examination and History Taking, 3rd Edition, adapts the proven techniques and vibrant visuals of Bates’ gold-standard assessment text specifically for the needs of today’s nursing students. Thoroughly updated, evidence-based coverage emphasizes the healthy patient and clearly details common findings and diseases to help students develop and practice key skills in physical examination and history taking. Content is logically organized by Foundations, Body Systems, and Special Lifespan Considerations, incorporating essential review of anatomy and physiology, as well as critical practice in health history review, recording findings, and health promotion. Reflecting the latest research in the field, including emerging issues such as vaping, the opioid crisis, and the COVID-19 pandemic, the 3rd Edition combines trusted approaches with current clinical perspectives to equip your students for success throughout their nursing careers. Table of Contents Unit 1—Foundations Chapter 1. Intro to Health Assessment and Social Determinants of Health Chapter 2. Critical Thinking and Clinical Judgement in Health Assessment Chapter 3. Interviewing and Communication Chapter 4. The Health History Chapter 5. Cultural and Spiritual Assessment Chapter 6. Physical Examination: Let’s Get Started Chapter 7. Beginning the Physical Examination: General Survey, Vital Signs, and Pain Chapter 8. Nutrition and Hydration Unit 2—Body Systems Chapter 9. The Integumentary System Chapter 10. The Head and Neck Chapter 11.The Eyes Chapter 12. Ears, Nose, Mouth, and Throat Chapter 13. The Respiratory System Chapter 14. The Cardiovascular System Chapter 15. The Peripheral Vascular System and Lymphatic System Chapter 16. The Gastrointestinal and Renal Systems Chapter 17. The Breasts and Axillae Chapter 18. The Musculoskeletal System Chapter 19. Mental Status and Mental Health Assessment Chapter 20. The Nervous System Chapter 21. Reproductive Systems Chapter 22. Putting the Physical Examination All Together Unit 3—Special Lifespan Chapter 23. Assessing Children: Infancy Through Adolescence Chapter 24. Assessing Older Adults Glossary

Read more less

Book SynopsisContinuing a legacy of excellence that spans nearly five decades, Bates’ Nursing Guide to Physical Examination and History Taking, 3rd Edition, adapts the proven techniques and vibrant visuals of Bates’ gold-standard assessment text specifically for the needs of today’s nursing students. Thoroughly updated, evidence-based coverage emphasizes the healthy patient and clearly details common findings and diseases to help students develop and practice key skills in physical examination and history taking. Content is logically organized by Foundations, Body Systems, and Special Lifespan Considerations, incorporating essential review of anatomy and physiology, as well as critical practice in health history review, recording findings, and health promotion. Reflecting the latest research in the field, including emerging issues such as vaping, the opioid crisis, and the COVID-19 pandemic, the 3rd Edition combines trusted approaches with current clinical perspectives to equip your students for success throughout their nursing careers.

Read more less

Book SynopsisClearly written, colorfully designed, and updated with the most current, evidence-based nursing considerations, Health Assessment in Nursing, 7th Edition helps students develop the comprehensive knowledge base and expert nursing assessment skills to confidently perform accurate, timely health assessments in a variety of healthcare settings. This popular, student-friendly text is known for its innovative 2- and 3-column design and intuitive organization, presenting in-depth assessment information alongside dynamic visuals to make concepts easy to understand. Powerful learning tools in the text and available online further hone students’ data collection capabilities and cultivate the critical thinking skills students need to analyze data and detect client problems. Reflecting the latest trends and topical issues facing today’s practicing nurses — including opioid use and human trafficking — this 7th Edition equips students with the assessment, documentation, and analytical skills to meet the clinical challenges ahead and ensure successful client outcomes throughout their nursing careers.

Read more less

Book SynopsisAwarded second place in the 2023 AJN Book of the Year Awards in the Medical-Surgical Nursing category. Combining the fundamental coverage of a traditional nursing assessment text with a modern, student-friendly presentation and an enhanced emphasis on clinical judgment, Nursing Health Assessment: A Clinical Judgment Approach, 4th Edition, helps students easily develop the understanding, critical thinking, and decision-making skills to excel in any clinical setting. A consistent, two-column format presents normal and abnormal findings and guides students progressively through realistic clinical case scenarios, instilling the nursing knowledge to observe and assess situations, prioritize patient concerns, and generate the best possible solutions. Case-based Next Generation NCLEX® (NGN) style questions throughout the text (and answers with rationales in an appendix) align with the NCSBN Clinical Judgment Model (NCJMM) to prepare students for success on the Next Generation NCLEX® and to help them confidently deliver safe patient care in any clinical setting. New and Updated Features for the 4th Edition NEW! 180 case-based Next Generation NCLEX® (NGN) style questions (and answers with rationales) boost students’ exam readiness and test-taking confidence. NEW! NCSBN Clinical Judgment Measurement Model (NCJMM) cues, hypotheses, and evaluation components incorporated into case studies throughout the text strengthen students’ critical thinking and decision-making capabilities. UPDATED! New and revised content familiarizes students with social determinants of health, incorporates unbiased language, and reflects current infection and source control measures. UPDATED! Diagnoses incorporate International Classification for Nursing Practice [ICNP] language to clarify challenging terminology.

Read more less

Book SynopsisCombining the fundamental coverage of a traditional nursing assessment text with a modern, student-friendly presentation and an enhanced emphasis on clinical judgment, Nursing Health Assessment: A Clinical Judgment Approach, 4th Edition, helps students easily develop the understanding, critical thinking, and decision-making skills to excel in any clinical setting. A consistent, two-column format presents normal and abnormal findings and guides students progressively through realistic clinical case scenarios, instilling the nursing knowledge to observe and assess situations, prioritize patient concerns, and generate the best possible solutions. Case-based Next Generation NCLEX® (NGN) style questions throughout the text (and answers with rationales in an appendix) align with the NCSBN Clinical Judgment Model (NCJMM) to prepare students for success on the Next Generation NCLEX® and to help them confidently deliver safe patient care in any clinical setting. New and Updated Features for the 4th Edition NEW! 180 case-based Next Generation NCLEX® (NGN) style questions (and answers with rationales) boost students’ exam readiness and test-taking confidence. NEW! NCSBN Clinical Judgment Measurement Model (NCJMM) cues, hypotheses, and evaluation components incorporated into case studies throughout the text strengthen students’ critical thinking and decision-making capabilities. UPDATED! New and revised content familiarizes students with social determinants of health, incorporates unbiased language, and reflects current infection and source control measures. UPDATED! Diagnoses incorporate International Classification for Nursing Practice [INCP] language to clarify challenging terminology.

Read more less

Book SynopsisConfidently provide best practices in patient care, with the newly updated Lippincott® Nursing Procedures, 9th Edition. More than 400 entries offer detailed, evidence-based guidance on procedures ranging from the most basic patient care to assisting with intricate surgeries. The alphabetical organization allows you to quickly look up any procedure by name, and benefit from the clear, concise, step-by-step direction of nursing experts. Whether you’re a nursing student, are new to nursing, or are a seasoned practitioner, this is your go-to guide to the latest in expert care and positive outcomes. Ensure a high level of nursing expertise with this practical, quick-reference guide. This edition offers: NEW entries with evidence-based direction on: Ankle-brachial index calculation Biohazardous waste handling Cultural assessment Elastomeric pump use Hazardous drug preparation and handling Hazardous drug spill management Nasal decolonization Opioid withdrawal management Post-traumatic stress disorder assessment Prone positioning for the awake patient Sepsis emergency patient care Wound photography Colored letter tabs at the top of each page that allow quick-and-easy locating of any entry Full-color photos and diagrams that illustrate procedure steps with a quick-read, bulleted format that walks you through each procedure Practices based on clinical evidence—recent studies supporting best practices are cited Colorful, eye-catching special alerts: Nursing Alerts – Potentially dangerous actions or clinically significant findings related to a procedure Pediatric Alerts – Special precautions to take while treating infants, young children, and adolescents Elder Alerts – Elder patient special needs Hospital-Acquired Condition Alerts – Conditions the Centers for Medicare and Medicaid Services have identified as events that may occur during hospitalization Procedures presented in a structured how-to format: Equipment – Types of equipment needed for procedure Preparation of equipment – Guidance on preparing any needed equipment for procedure Implementation – Step-by-step guidance for performing procedure Special considerations – Factors to keep in mind that can affect the procedure Troubleshooting – Methods for troubleshooting equipment issues, with step-by-step interventions Patient teaching – Helpful tips, reminders, and follow-up instructions before patient discharge Complications – Procedure-related complications to watch for Documentation – Everything needed to document the procedure fully

Read more less

Book SynopsisBates’ Guide to Physical Examination and History Taking 14th Edition is the trusted resource for mastering patient assessment, carefully tailored to meet the evolving needs of students, educators, and healthcare practitioners. Whether you’re beginning your career in healthcare or seeking to enhance your clinical skills, this updated edition has been thoughtfully updated to address the evolving needs of today’s healthcare landscape. By focusing on enhancing clinical reasoning through the integration of common symptoms with high-yield health history questions, it empowers users to conduct more accurate and effective patient evaluations. With a refined two-column layout, new high-quality images, and expanded tables, the content is both comprehensive and accessible. The inclusion of point-of-care ultrasound (POCUS) techniques in regional physical examination chapters, where they correlate with specific PE findings, further enriches the learning and diagnostic process. Additionally, the text incorporates inclusive language and thoughtfully addresses health disparities, ensuring a holistic approach to patient care. This edition is an indispensable resource for those committed to mastering patient assessment and excelling in today’s healthcare environment. NEW! Common symptoms with high-yield health history questions are integrated throughout, emphasizing that clinical reasoning skills are at the core of effective interviewing and PE techniques. NEW! POCUS techniques and a dedicated ultrasound chapter provide an understanding of how ultrasound can elevate PE skills, improving diagnostic accuracy and confidence. NEW! Tables on PE modifications for patients with clinical devices and procedures, ensuring comprehensive and accurate assessments in complex cases. NEW! Clinical reasoning-focused interpretation of sample documentations, enhancing the practical application of diagnostic skills. UPDATED! Inclusive language and non-stigmatizing terminology are employed throughout, with health disparities framed within the context of Social Determinants of Health (SDH). Teaching and Learning Support: UPDATED! Integration with Connect Courseware, providing seamless access to interactive learning modules, customizable course content, and progress tracking tools. 

Read more less

Book SynopsisDesigned to help health care professionals who are looking for a simple, step-by-step approach to math calculations, Dosage Calculations Made Incredibly Easy! 6th edition is a fully illustrated guide that offers the complete how-to on calculating dosages for all drug forms and administration routes. It explains how to work with different formulas such as ratios, proportions, ratio proportions, and the 'Desired Over Have' formula. Whether you have a little or a lot of experience working with formulas, conversions, or rounding numbers, the information in this book will help you apply medication administration principles in the clinical setting. Topics include: math basics such as fractions, decimals, and percentages measurement systems and conversions calculating oral, topical, liquid, and rectal drug dosages calculating parenteral injections and IV infusions calculating pediatric, obstetric, and critical car

Read more less

Book SynopsisOver the last decade, technical advances have allowed genomic testing which provides a great opportunity for diagnosis but also an increased chance of uncertain or unexpected findings. This book addresses many of the questions that arise in this context and summarizes the essential concepts in diagnostic genetic testing in an easy-to-read manner. It also covers some broad context for the practical and ethical implications of examining human DNA sequences. The book starts with a general introduction to the field, providing enough background to allow readers without any previous education in genetics to comprehend the material in the subsequent chapters. The main part explores differing aspects of human genetics and the wider implications of testing in these areas. The author covers not only single gene inheritance, but also genetic testing of cancers and how testing benefits the patients. Special emphasis is also given to the questions of genetics and identity. The concluding part then draws the main themes together and summarises the wider significance of genetics. It also explores the gap between promises made for the impact of advances in genetics, and the actual benefits to patients. The book is written for everyone interested to learn about the process of genetic testing and the broader implications. Moreover, it is aimed at health professionals with an interest in genetics, at students or scientific trainees looking for an introduction to diagnostic genetics, and at professionals in health policy or health journalism.Table of ContentsChapter 1: Genetic testing, some themes and some basics· Brief introduction to genetic testing. · Themes o Complexity o Risk and uncertainty o DNA and identities o Future promises and limitations · Genetic basics o Information storage and copying o Chromosomes and inheritance patterns o Genes in genomes (nuclear and mitochondrial) o Transcription, translation and the genetic code o Mutation · Basic techniques of genetic testing o DNA extraction o Hybridisation o PCR and DNA amplification o Electrophoresis o DNA sequencing Chapter 2: Huntington disease, a severe autosomal recessive disorder · Huntington disease (HD) · Mutation mechanism and gain of function · Trinucleotide repeat expansions · Penetrance and genotype/phenotype correlation · Anticipation · Testing for HD and test metrics · Rationales for testing · Laboratory error · Ethical problems (sharing information) Chapter 3: Autosomal recessive inheritance and cystic fibrosis · Cystic fibrosis (CF) · Spectrum of mutations · Recessive disorders in populations (founder effect) · Testing for CF · Rationales for testing including neonatal screening · Prenatal diagnosis and ethical issues · Genetics and therapy for CF · Risk and uncertainty Chapter 4: X-linked inheritance: a question of gender · Chromosome number / balance (XX vs. XY) and X-inactivation · DNA methylation and epigenetics · DMD/BMD (genotype/phenotype correlation) · Mosaicism · Sharing genetic information · Androgen receptor gene and different phenotypes · Genetics and gender Chapter 5: Cancer genetics: acquired and inherited mutations · Cancer as a genetic disease · Tumour suppressors and oncogenes in the control of growth · Somatic/germline distinction · Genetic stratification and cancer treatment · Uncertainties and predictive testing · Future possibilities: liquid biopsy / ctDNA Chapter 6: Genes and identity · Forensic and laboratory identity testing · Uses of short tandem repeat markers in diagnostic genetics · DNA as a measure of identity · Relationships within and outside humanity · Problems with the concept of personal identity Chapter 7: Genome scale testing · Development of methods from chromosome analysis to next generation sequencing · Testing strategies (whole genome, whole exome, gene panels) · Utility of genome testing (many genes examined simultaneously, new causes identified, NIPD, cancer testing, de novo changes) · Assigning pathogenicity · Polygenic / multifactorial inheritance · Limitations and the ethics of inflated claims Chapter 8: DNA testing- pulling the strands together · Fundamentals of genetic testing and access to testing · Consent · Autonomy · Avoiding harm · Uncertainty, risk and biases · Benefits of genetics · The language of genetics (in the genetic code and in everyday language) Appendix: List of technical terms with page references to a definition in the text

Read more less

Book SynopsisThis textbook helps nurses, physician assistants, medical students and residents to order appropriate tests and understand how to interpret them to improve their diagnostic reasoning. Children are not like adults, and interpreting of the results of their diagnostic laboratory tests requires knowledge of the biochemical and metabolic differences. Using a combination of information, questions and case studies, the book allows readers to gain an understanding of the key concepts of sensitivity, specificity, and positive and negative predictive values, as well as the indications for diagnostic lab tests. This textbook presents the state of art in testing across body systems and guidance on how to order and interpret diagnostic laboratory tests in pediatric patients. Each chapter includes learning objectives, tables and figures, as well as questions and references for further learning. This textbook provides an update for clinicians and is a valuable learning tool for students and new clinicians. . Table of Contents1. Pediatric Diagnostic Lab Tests: An Overview 2. Laboratory Screening and Diagnostic Testing in Antepartum Care 3. Care of the Newborn 4. The Well Pediatric Primary Care Visit and Screening Laboratory Tests 5. PointofCare Testing in Primary Care 6. Care of the Child with an Infectious Disease or Immunological Defect 7. Genetics and Pediatric Patient 8. Hematology 9. Care of the Child with a Gastrointestinal Disorder 10. Care of the Child with a Renal Problem 11. Care of the Child with a Pediatric Endocrine Disorder 12. Care of the Child with a Possible Rheumatological Disorder

Read more less

Book SynopsisThis book is the first comprehensive text dedicated to risk assessment in the primary prevention of atherosclerotic cardiovascular disease. It provides an overview of current evidence regarding approaches to risk assessment, traditional and emerging risk factors, and atherosclerosis imaging for refinement of risk estimation. The volume seeks to provide an essential resource for professionals in the field to assess their patients for risk of cardiovascular disease. The book is divided into five sections, starting off with an overview of current best practices to risk assessment in primary prevention around the world. The second section discusses traditional risk factors, such as hypercholesterolemia, hypertension, diabetes, smoking, and obesity. The third section reviews the newly introduced concept of ‘Risk Enhancers’. The fourth section offers insight on novel risk factors, with in-depth discussion regarding lipoprotein(a), high-sensitivity CRP, apolipoprotein B, social determinants of health, stress and cardiovascular disease. and polygenic risk scores. The final section covers the use of non-invasive atherosclerosis imaging (computed tomography and ultrasound-based techniques) as a tool to refine risk estimates. Throughout the book, readers will find multiple tables, figures, and illustrations that complement the text. Up-to-date, evidence-based, and clinically oriented, Cardiovascular Risk Assessment in Primary Prevention is a must-have resource for physicians, residents, fellows, and medical students in cardiology, endocrinology, primary care, and health promotion and disease prevention.Table of ContentsSection 1General Principles and Approach to Risk Assessment in Primary Prevention – Anne Marie Navar (Duke University)U.S. Guidelines – Roger Blumenthal (Johns Hopkins University)European Guidelines – Salim Virani (Baylor College of Medicine)Canadian Guidelines – Robert Hegele (Robarts Research Institute; Ontario, Canada)Asian Guidelines – Mariko Harada-Shiba (National Cerebral and Cardiovascular Center; Japan)Section 2 - Traditional Risk FactorsHypercholesterolemia – Christie Ballantyne (Baylor College of Medicine)Hypertension – Ron Blankstein (Brigham and Women’s Hospital)Diabetes – Mikhail Kosiborod (University of Missouri – Kansas City)Smoking – Pamela Morris (Medical University of South Carolina)Obesity - Jamie Ard (Wake Forest University School of Medicine)Section 3 - Risk EnhancersFamily history of premature atherosclerotic cardiovascular disease – Amit Khera (UT Southwestern)Conditions Specific to Women – Martha Gulati (University of Arizona – Phoenix)Ethnic Factors – Pam Taub (UC San Diego)Triglyceride Rich Lipoproteins – Sergio Fazio (Oregon Health & Science University)Inflammatory Diseases – Erin Michos (Johns Hopkins University)Chronic Kidney Disease – Barry Freedman (Wake Forest University School of Medicine)Metabolic Syndrome – Harold Bays (Louisville Metabolic and Atherosclerosis)Ankle Brachial Index – Peter Toth (CGH Medical Center)Section 4 – Novel Risk FactorsLipoprotein(a) – Mike Blaha (Johns Hopkins University)High-sensitivity C-Reactive Protein - Paul Ridker (Brigham and Women’s Hospital)Apolipoprotein B – Seth Martin (Johns Hopkins University)Social Determinants of Health – Keith Ferdinand (Tulane University)Clonal Hematopoiesis of Indeterminate Potential – Pradeep Natarajan (Massachusetts General Hospital)Polygenic Risk Scores – Amit Khera (Massachusetts General Hospital)Metabolomics – David Herrington (Wake Forest University School of Medicine)Section 5 – Atherosclerosis Imaging as a Tool to Refine Risk EstimatesCoronary Artery Calcium Score – Khurram Nasir (Houston Methodist Debakey Heart Center)Coronary Computed Tomography Angiography – Kavitha Chinnaiyan (Beaumont Health)Carotid Intima-Media Thickness – Jim Stein (University of Wisconsin)

Read more less

Book SynopsisNow in its second edition, this atlas serves as an easy-to-use diagnostic guide for the analysis of the human karyotype. Split in four parts, it starts with a comprehensive introduction covering the molecular cytogenetic basics, the role of ethic committees and international quality control in the field of diagnostics. The main parts II and III show the spectrum of different types of chromosomal abnormalities by a combination of karyogram and ideogram. They compare the significance of different banding techniques, give the karyotype formula and describe morphological peculiarities of each case presented. The final part provides a detailed description of non-coding DNA variants and focuses on potential problems in the detection of aberrations. It also mentions necessary additional investigations and peculiarities to be considered when counselling carriers of a chromosomal aberration or their relatives. Given its comprehensive scope and practical approach, this atlas is an indispensable resource for researchers, clinicians and practitioners working in the field of cytogenetics and clinical genetics.Table of ContentsContents Preface Part I: Introduction 1 Social Attitude towards Disabled People – Historical and Cultural Aspects 1.1 Monstrosities: Consequence of Sin versus Play of Nature 1.2 „Cripples“: The Power of Imagination, Crippled Mind and Show Business 1.3 Changing Social Attitude 2 The Role of Ethics Committees 3 Quality Control in the Field of Diagnostics 4 Types of Chromosome Mutations 4.1 Intrachromosomal Rearrangements 4.1.1 Inversions 4.1.1.1 Pericentric Inversions 4.1.1.2 Paracentric Inversions 4.1.2 Deletions 4.1.3 Duplications 4.1.4 Ring Chromosomes 4.1.5 Isochromosomes 4.2 Interchromosomal Rearrangements 4.2.1 Translocations 4.2.1.1 Reciprocal Translocations 4.2.1.2 Robertsonian Translocations or Centric Fusions 4.2.2 Insertions 4.2.3 Complex Chromosome Rearrangements (CCR) 4.2.4 Marker Chromosomes (Chromosome Derivates) 5 Heteromorphisms 5.1 Euchromatic Variants 5.2 Satellites 5.3 Nucleolus Organising Regions (NOR-Region) 5.4 Pericentromeric Heterochromatin 5.5 Centromere 5.6 Heterochromatic Blocks Part II: Single Case Presentations of Intrachromosomal Rearrangements 6 Inversions 7 Deletions 8 Duplications 9 Ring Chromosomes 10 Isochromosomes Part III: Single Case Presentations of Interchromosomal Rearrangements 11 Translocations 12 Insertions 13 Complex Chromosome Rearrangements (CCR) 14 Marker Chromosomes 15 Mutations in Non-Coding DNA Regions 15.1 Euchromatic Variants 15.2 Satellites 15.3 Nucleolus Organising Regions (NOR-Regions) 15.4 Pericentromeric Heterochromatin 15.5 Centromeres 15.6 Heterochromatic Blocks Part IV: Guidelines 16 Genetic Counseling Procedures 16.1 Overview 16.2 Case Reports 16.2.1 Carrier of Unbalanced Translocation 16/21 de novo 16.2.2 Familial Translocation Y/22 16.2.3 Familial Translocation 4/22 16.2.4 Homologous Translocation 2/2 de novo 16.2.5 Mosaic Translocation Trisomy 21 17 Life Courses 17.1 Overview 17.2 Case Reports 17.2.1 Carrier of Interstitial Deletion 9q de novo 17.2.2 Carrier of Unbalanced Translocation 14/21 17.2.3 Carrier of a Duplication 3q derived from a Familial Translocation 17.2.4 Carrier of an Interstitial Duplication 3q de novo 17.2.5 Carrier of a Terminal Deletion 18q de novo 18 Support Groups 19 Diagnostic Procedere 20 Outlook References Acknowledgement

Read more less

Book SynopsisThis book helps nursing students increase the quality of their clinical reasoning and therefore the quality of care. It teaches students to recognize when clinical reasoning is needed, and what reasoning is involved, and to avoid reasoning errors. This is important for nurses, since good quality of their clinical reasoning leads to a good quality of their decisions. Thus, it is directly connected to better nursing care. This volume is based on current knowledge about learning complex cognitive skills. From this knowledge, four sets of standard questions have been formulated that allow students to develop cognitive scripts for reasoning about diagnosis, etiology, prognosis, and interventions. Special attention is payed to diversity-sensitive reasoning in this English edition. From the 4C/ID model, a scientific educational whole task model for learning and developing and complex cognitive skills, complexity levels, learning tasks and subtask exercises are included. Learning clinical reasoning is supported with case videos and flash lectures, among other things. It consists of three parts: the first part, on clinical reasoning, is written for first- and second-year bachelor students in nursing. Part two, on evidence-based practice (EBP), is also suitable for later years. It teaches students to read and critically appraise scientific articles, and to assess whether they can be used in their own practice. Part three contains more in-depth information, extra explanations, examples, and material that teachers can use in a flexible way. This book is illustrated with videos.The translation from Dutch to English was done with the help of artificial intelligence (machine translation by the service DeepL.com). The authors have subsequently revised the text further in an endeavour to refine the work stylistically.Table of ContentsPart 1 Clinical reasoning1. Background knowledge 2. Decision on diagnosis: what is the problem?3. Decision on etiology: what caused the problem?4. Decision on prognosis: what can be achieved?5. Decision on therapy: what can we do about the problem?Part 2 Evidence-based practice6. Clinical reasoning and evidence-based practice7. What is the problem: how to appraise scientific articles on diagnostic tests?8. What caused the problem: how to appraise scientific articles on etiological factors?9. What can be achieved: how to appraise scientific articles on prognostic research?10. What can we do about the problem: how to appraise scientific articles on interventions?11. How to reach a better understanding of the patients' perspective: reading and appraising qualitative researchPart 3 Extra's12. this part is one chapter with many short paragraphs related to, and deepening the content related to the previous chapters. E.g. clinical examples and elaborations.13. Education about clinical reasoning and evidence-based practice.

Read more less

Book Synopsis

Read more less

Book SynopsisThis book provides a practical and secure guide through the complexity of Autoimmune Diagnostics and Diagnostic Pathways. It contains an overview of significant aspects of Autoimmune Diagnostics, a standard procedure for indirect immunofluorescence and describes all important autoimmune diseases in terms of their diagnostic. In step with actual practice the innovative concept of Diagnostic Pathways leads from symptoms through all steps and branches to diagnosis.

Read more less

Book SynopsisToday most of immunochemistry methods for the determination of proteins, peptides, drugs, and many small molecules are fully automated, with good precision, excellent sensitivity and short reaction time. However, inaccuracy due to poor standardization and the presence of interfering substances in biological samples is still a serious and life-threatening issue. Proper validation of methods and quality assurance have little effect on frequency of occurrence of false positive or false negative results, which, if unrecognized, may lead to patient's misdiagnosis, unnecessary treatment or even unnecessary surgery. Deep knowledge of basic principles of immunochemical methods (antigen-antibody reaction, standardization, matrix effect, limit of detection, cross-reactivity, etc.), sources of analyte-independent interferences (preanalitycal errors, the presence of binding proteins, the presence of autoantibodies) and analyte-dependent interferences (presence of heterophilic antibodies, high-dose effect) are very important to understand, detect, reduce and/or eliminate the interferences. This book helps to reduce false results and, at the same time, improve patient's care and patient's safety.Table of ContentsImmunodiagnostics and patient safety Table of contents1. Overview of immunochemistry (basic principles, standardization, limit of detection, cross-reactivity, ect)2. Interferences in immunochemistrya. Matrix effectsb. Preanalitycal factorsc. Binding proteinsd. Macroforms of proteinse. High-dose effectf. Heterophilic antibodyg. Anti-animal antibodyh. Autoantibody3. Methods of detection and reduction of interferences 4. The impact of interferences on patients safety - examples

Read more less

Book SynopsisBlood transfusion is considered a life-saving therapy since ancient times, but, at the same time, a high-risk procedure. Nowadays the common perception is that infection is the greatest risk, even if the blood has never been safer from this point of view. Currently, the residual risk of transfusion must be related mainly to immunological mechanisms underlying to AB0 and minor blood systems, to compatibility of blood transfused and to development of irregular antibodies in transfused patients. "Transfusion Medicine and Patient Safety" aims to provide the basic of immunohematology to readers and to analyze the transfusional process highlighting the most critical points, thus more exposed to errors. Screening on blood and blood components for infectious diseases along with the surveillance action on emerging viruses results in the drastic reduction of post-transfusion infection, together with the potential to further increase the level of security from infection through the inactivation of blood components.The text also describes the major diagnostic systems and organizational models that modern technology provides us with a correct immunohematological diagnosis and an appropriate trasfusional therapy.

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book SynopsisThe Third Edition of this up-to-date and user friendly workbook helps medical students, sonographers, residents, and radiologists gain a fundamental grasp of the application of color duplex ultrasound by reviewing normal findings, important pathologic conditions, scanning techniques, and the role and importance of color duplex ultrasound in detecting and assessing various disease states. Topics include: Basic physical and technical principles Innovative techniques and ultrasound contrast agents (e.g., power Doppler, SieScape imaging, clarify vascular enhancement, tissue Doppler, precision upsampling, arterial stiffness, eTracking) Vascular surgery: peripheral arterial occlusive disease, venous insufficiency and thrombosis, AV fistulae, and aneurysms Endocrinology: thyroid gland Internal medicine: abdominal organs, lymph nodes, TIPSS Nephrology: kidneys and renal allografts Neurology: intra- and extracranial cerebral arteries Cardiology: B- and M-mode imaging, cardiac anomalies, wall motion analysis Urology: testicular torsion, tumors, erectile dysfunction Obstetrics and gynecology: tumors, anomalies, fetal perfusion defects Teaching Manual of Color Duplex Sonography is well known for its highly educational approach and user-friendly features which include: Over 500 excellent illustrations -- ideal for visually oriented learners Diagrams that illustrate the correct way to handle the transducer and position the scan plane Self-test question & answers Tips, tricks, and common pitfalls Checklists and tables of normal values on sturdy pocket-sized cards for hospital and office use

Read more less

Book SynopsisDifferential Diagnosis in Ultrasound Imaging, Second Edition, is a complete revision and extension of this best-selling Thieme title, bringing it up to date with the very latest clinical and technological standards. With a specific focus on general abdominal, genitourinary, and thyroid pathologies, it guides readers systematically through the process of sonographic differential diagnosis. The inclusion of images with variant courses and atypical sonographs ensures comprehensive coverage of this highly efficient diagnostic tool. Key features of the second edition: More than 1,100 new high-quality images, bringing the total number of illustrations to over 2,800 Draws upon the full spectrum of modern ultrasound modalities, including contrast-enhanced ultrasound (CEUS), Doppler, color Doppler, and elastography Navigational flow charts included in each chapter summarize possible diagnoses at a glance to ensure swift access to key information Clear layout with color-coded text boxes and tips, tricks, and pitfalls to help guide readers through the differential diagnosis process This new edition will be an essential reference for all residents and physicians using ultrasound on a day-to-day basis for diagnostic purposes, including practicing radiologists, internists, and ultrasound technicians.Table of Contents1 Vessels 2 Liver 3 Biliary Tree and Gallbladder 4 Pancreas 5 Spleen 6 Lymph Nodes 7 Gastrointestinal Tract 8 Peritoneal Cavity 9 Kidneys 10 Adrenal Glands 11 Urinary Tract 12 Prostate, Seminal Vesicles, Testis, Epididymis 13 Female Genital Tract 14 Thyroid Gland 15 Pleura and Chest Wall 16 Lung

Read more less

Book SynopsisA practical approach to the early detection and management of breast cancer This atlas provides radiologists with essential information for the differential diagnosis of breast diseases on the basis of clinical presentation, mammography, and ultrasound. It begins with chapters on tumor biology, prognostic factors, and histology. The authors then provide a thorough evaluation of various methods for early detection and accurate diagnosis, including analog and digital mammography, ultrasound, MR imaging, PET/CT, and interventional procedures. They discuss in detail the strengths and limitations of each imaging modality, aspects of quality control, test intervals, peri- and postoperative management principles, and follow-up care. Highlights: Presentation of difficult cases that effectively demonstrate the diagnostic hurdles and forensic pitfalls in breast diagnosis Special sections on breast cancer in men and young women, with discussion of women who are pregnant or lactating Color-coded practical tips and clinical notes for optimal comprehension of the material Extensive Q&A sections for self-testing in two major chapters More than 1,700 high-quality illustrations, including clinical color photographs, ultrasound images, and mammograms Trade Review"I believe that this outstanding modern book will be highly valued by radiologists, oncologists, surgeons and many other specialists."—British Journal of Radiology "Every page contains an opportunity to increase the user's knowledge,."—Radiologic TechnologyTable of Contents1 Introduction 2 Aspects of Tumor Biology Causes, Growth Factors, Endocrine and Exocrine Influences Hormone Replacement Therapy in Menopause Predisposing Genetic Factors Case-Control Study on Sports and Breast Cancer Summary 3 Prognostic Factors Growth Rate, Tumor Size, Lymph Node Involvement, and Prognosis 4 Macroanatomy, Histology, Radiography, and Ultrasound Anatomy of the Breast: Lobes, Lobules, and the Terminal Duct Lobular Unit (TDLU) Terminal Duct Lobular Unit: Microradiography, Mammography, and Sonography Conclusions 5 Early Detection and Appropriate Treatment Diagnostic Options Possibilities and Limitations of Complementary Investigations Therapy and Perioperative Management Postoperative Changes and Follow-Up Answers 6 Summary

Read more less

Book SynopsisNow in a greatly expanded and updated new edition: The essential pocketbook for rapid and correct differentiation and interpretation of signs and symptoms of neurological and neurosurgical diseases and conditions.Key Features: Exhaustive range of neurologic and neurosurgical disease and conditions covered Vital information presented in short texts, high-yield lists, and concise tables, for maximum efficiency in diagnostic work-ups Clinical and neuroimaging findings, guidelines and classifications, summarized in readily accessible tabular form Statistic overviews (common vs. rare, etc.) help guide diagnostic thought processes Special chapters highlight epidemiology, pediatric disorders, neuroradiology Differential Diagnosis in Neurology and Neurosurgery is ideal as a quick reference in your daily practice, or as an exam preparation guide. This wealth of easily accessed information makes it inv

Read more less

Book SynopsisThe third updated and revised edition of Differential Diagnosis in Conventional Radiology provides essential information to make conventional x-ray an effective tool in diagnosing disorders affecting the bones and joints and the thoracic and abdominal body segments. The book is organized according to classifications of radiologic findings rather than disease, enabling the reader to approach diagnosis in a way that reflects the actual clinical situation. Concise and comprehensive tables outline key information on diagnosis and differential diagnosis. Highlights: The unique organization of chapters based on radiologic findings mirrors the situations encountered in daily clinical practice Easy-to-reference tables classifying findings, diagnosis, and differential diagnosis and providing important clinical data are perfect for an at-a-glance review More than 2000 radiographs and schematic diagrams help to guide the reader toward the most likely diagnoses The third edition of Differential Diagnosis in Conventional Radiology contains an updated and revised section on radiology of the abdomen combined with the complete text from the recently published books Bone and Joint Disorders and The Chest X-Ray by the same authors. An exceptional reference work to have on hand, Differential Diagnosis in Conventional Radiology will benefit radiologists and specialists seeking to improve their skills in diagnostic imaging and will also be of great interest to residents preparing for their specialist examinations.Trade ReviewEach section is richly illustrated with good examples of the abnormality. The authors should be congratulated on amassing such a fine collection of radiographs...an excellent book that is simple to use and has beautiful images. The logical arrangement and the ease with which the tables can be read make this one of the classic radiology books...This is certainly a must-have for any radiology department.--Radiology[This edition is] enrichd by a new, up-to-date, and enlarged section dealing with the radiological imaging of the abdomen...Easy to read...All the chapters are enriched by clear tables...Richly illustrated...Will be of great aid to the junior residents in radiology...Could definitely be used as a refresher course before the board exam.-- Clinical ImagingTable of ContentsBone 1 Osteopenia 2 Osteosclerosis 3 Periosteal Reactions 4 Trauma and Fractures 5 Localized Bone Lesions 6 Joint Diseases 7 Joint and Soft-Tissue Calcification 8 Skull 9 Orbits 10 Nasal Fossa and Paranasal Sinuses 11 Jaws and Teeth 12 Spine and Pelvis 13 Clavicles, Ribs, and Sternum 14 Extremities 15 Hands and Feet Chest 16 Cardiac Enlargement 17 Mediastinal or Hilar Enlargement 18 Pleura and Diaphragm 19 Intrathoracic Calcification 20 Alveolar Infiltrates and Atelectasis 21 Interstitial Lung Disease 22 Pulmonary Edema and Symmetrical Bilateral Infiltrates 23 Pulmonary Nodules and Mass Lesions 24 Pulmonary Cavitary and Cystic Lesions 25 Hyperlucent Lung Abdomen 26 Abnormal Abdominal Gas Patterns and Dilatation and Motility Disorders in the Gastrointestinal Tract 27 Abdominal Calcifications 28 Abnormal Mucosal Pattern in the Gastrointestinal Tract 29 Narrowing in the Gastrointestinal Tract 30 Filling Defects in the Gastrointestinal Tract 31 Ulcers, Diverticula, and Fistulas in the Gastrointestinal Tract 32 Gallbladder and Bile Duct Abnormalities 33 Abnormal Renal Papillae and Calices 34 Filling Defects in the Urinary Tract 35 Urinary Tract Obstruction and Dilatation

Read more less

Book SynopsisHighlights the importance and benefit of mass spectrometry-based metabolomics for identifying biomarkers that accurately screen for potential biomarkers of diseases Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of human disease. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines comprehensively presents the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics such as metabolites analysis, biomarker discovery, technical challenges, discovery of natural product, mechanism interpretation of action, discovery of active ingredients, clinical application and precision medicine, and enhancing their biomedical value in a real world of biomedicine, shedding light on the potential for spectrometry-based metabolomics. It highlights the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. Each chapter has been laid out with introduction, method, up-to-date literature, identification of biomarker, and applications Covers the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics in the discovery of biomarker, active ingredients, natural product, etc. Constitutes a unique and indispensable practical guide for any phytochemistry or related laboratory, and provides hands-on description of new techniques Provides a guide for new practitioners of pharmacologists, pharmacological scholars, drug developers, botanist, researchers of traditional medicines. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines provides a landmark of mass spectrometry-based metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all biomedical science fields.Table of ContentsPreface xiii 1 Current State of the Art of High-Throughput Metabolomics 1Aihua Zhang, Qiang Yang, Hui Sun, and Xijun Wang 1.1 Introduction 1 1.2 Metabolomics 1 1.3 Mass Spectrometry Technology 2 1.4 Recent Advancements and Applications 4 1.4.1 Disease Diagnoses and Metabolism 4 1.4.2 Metabolic Mechanisms 6 1.4.3 Drug Efficacy 7 1.4.4 Nutrition 7 1.4.5 Plant Biology 8 1.5 Limitation 8 1.6 Conclusions and Future Perspectives 9 Acknowledgments 9 References 9 2 Innovations in Analytical Techniques of Metabolomics 19Ling Kong, Aihua Zhang, Shi Qiu, and Xijun Wang 2.1 Introduction 19 2.2 Current Analytical Technologies of Metabolomics 20 2.3 Chromatography Platform 21 2.3.1 Gas Chromatography Technique 21 2.3.2 Liquid Chromatography Technique 21 2.3.3 Supercritical Fluid Chromatography Technique 22 2.3.4 Capillary Electrophoresis Chromatography Technique 22 2.4 Mass Spectrometry Platform 23 2.4.1 GC–MS Technique 23 2.4.2 LC–MS Technique 24 2.4.3 SFC–MS Technique 24 2.4.4 CE–MS Technique 24 2.5 Nuclear Magnetic Resonance Platform 25 2.6 Comprehensive and Multidimensional Analytical Platform 25 2.7 Conclusions 25 Acknowledgments 26 References 26 3 Sample Preparation Method for Mass Spectrometry-Based Metabolomics 33Shi Qiu, Aihua Zhang, Hui Sun, and Xijun Wang 3.1 Introduction 33 3.2 Sample Collection and Storage 34 3.2.1 Urine 34 3.2.2 Plasma and Serum 35 3.2.3 Cerebrospinal Fluids 35 3.2.4 Tissue Homogenates 35 3.2.5 Saliva 36 3.3 Sample Preparation and Processing 36 3.4 Application 37 3.5 Future Development 38 Acknowledgments 38 References 38 4 Multivariate Data Analysis Approach for Mass Spectrometry-Based Metabolomics 45Junling Ren, Aihua Zhang, Ling Kong, and Xijun Wang 4.1 Introduction 45 4.2 Separation-Based MS Techniques 46 4.2.1 Gas Chromatography–Mass Spectrometry 46 4.2.2 Liquid Chromatography–Mass Spectrometry 46 4.2.2.1 Reversed-Phase Liquid Chromatography–Mass Spectrometry 47 4.2.2.2 Hydrophilic Interaction Chromatography–Mass Spectrometry 47 4.2.2.3 Supercritical Fluid Chromatography–Mass Spectrometry 48 4.2.3 Capillary Electrophoresis–Mass Spectrometry 48 4.2.4 Ion Mobility–Mass Spectrometry 49 4.3 Separation-Free MS Techniques 49 4.3.1 Direct Infusion–Mass Spectrometry 49 4.3.2 Matrix-Assisted Laser Desorption Ionization–Mass Spectrometry 50 4.3.3 Mass Spectrometry Imaging 50 4.3.4 Direct Analysis in Real Time–Mass Spectrometry 51 4.4 Tools for MS Result Analysis 51 4.5 Multivariate Statistical Analysis Approach for Data Analysis 53 4.6 Limitations and Challenges 57 4.7 Conclusions and Future Perspectives 58 Acknowledgments 60 References 60 5 Mass Spectrometry-Driven Metabolomics for Metabolites and Metabolic Pathway Analysis 67Aihua Zhang, Hui Sun, Shi Qiu, and Xijun Wang 5.1 Introduction 67 5.2 Mass Spectrometry-Driven Metabolomics for Biomarker Discovery 69 5.3 Data Extraction and Analysis for Metabolites and Metabolic Pathway 69 5.4 Biomarker Identification 70 5.5 Applications 70 5.6 Conclusions 73 Acknowledgments 73 References 73 6 Metabolomics as Drivers for Biomarker Discovery and Mechanism Interpretation 81Wanying Wang, Aihua Zhang, Hui Sun, Guangli Yan, and Xijun Wang 6.1 Introduction 81 6.2 Metabolomics for Biomarker Discovery 82 6.3 Metabolomics for Mechanism Interpretation 83 6.4 Application 85 6.5 Current Trends and Future Perspectives 88 6.6 Conclusions 89 Acknowledgments 89 References 89 7 Current Status of Technical Challenges in Mass Spectrometry-Driven Metabolomics 97Shi Qiu, Aihua Zhang, Hui Sun, and Xijun Wang 7.1 Introduction 97 7.2 Metabolic Fingerprinting and Profiling 98 7.3 Non-targeted or Targeted Metabolomics 99 7.4 Metabolite Identification Bottleneck 99 7.5 Quality Control Bottleneck 101 7.6 Mass Spectrometry Techniques 102 7.6.1 LC–MS 102 7.6.2 GC–MS 103 7.6.3 NMR–MS 104 7.7 Prospects 105 7.8 Conclusions 105 Acknowledgments 105 References 106 8 The Application of Metabolomics in Cancer Management 113Aihua Zhang, Hui Sun, and Xijun Wang 8.1 Introduction 113 8.2 Epidemiology and Diagnosis 114 8.3 Prospective Biomarkers 114 8.4 Metabolomics Screening Biomarkers 117 8.5 Conclusions and Future Directions 117 Acknowledgments 118 References 118 9 Metabolomics in Coronary Heart Disease: From Biomarker Identification to Pathomechanism Insights 123Hui Sun, Aihua Zhang, Shi Qiu, and Xijun Wang 9.1 Introduction 123 9.2 Predicament 126 9.3 Metabolomics for CHD 126 9.4 Biomarker Dilemma 127 9.5 Lipid Metabolism 128 9.6 Treatment of Herbal Medicine 128 9.7 Conclusions and Future Direction 129 Acknowledgments 129 References 130 10 Metabolomics Applications in Neurological Disease 135Shi Qiu, Ying Han, Aihua Zhang, Hui Sun, and Xijun Wang 10.1 Introduction 135 10.2 CSF Sampling 136 10.3 Application of Metabolomics in CNS 136 10.4 Future Direction 137 10.5 Conclusions 138 Acknowledgments 139 References 139 11 Metabolomics Toward Precision Medicine 143Aihua Zhang, Shi Qiu, Hui Sun, Guangli Yan, and Xijun Wang 11.1 Introduction 143 11.2 Precision Medicine: A New Era of Medicine 144 11.3 Precision Biomarkers 145 11.4 Metabolomics as a Powerful Tool for Potential Biomarkers 146 11.5 Practical Application of Metabolomics 147 11.6 Precision Medicine for Herbal Medicine 148 11.7 Conclusions and Future Perspectives 150 Acknowledgments 151 References 151 12 Mass Spectrometry-Based Metabolomics Toward Biological Function Analysis 157Shi Qiu, Wanying Wang, Aihua Zhang, and Xijun Wang 12.1 Introduction 157 12.2 Current Trend and Challenge of Disease Phenotype 158 12.3 Advances in Mass Spectrometry Analytic Technique 158 12.4 Advantages of Mass Spectrometry-Based Metabolomics 159 12.5 Mass Spectrometry-Based Metabolomics for Biological Function 159 12.6 Limitations of MS-Based Metabolomics 165 12.7 Future Perspectives 165 12.8 Conclusions 166 Acknowledgments 166 References 166 13 Mass Spectrometry-Driven Active Ingredients Discovery from Herbal Medicine 171Wanying Wang, Aihua Zhang, Shi Qiu, and Xijun Wang 13.1 Introduction 171 13.2 An Overview of Herbal Medicine 172 13.3 Mass Spectrometry to Identify the Chemical Constituents 173 13.4 Mass Spectrometry for Constituent Analysis In Vivo 173 13.5 Mass Spectrometry-Based Chinmedomics Strategy 175 13.6 Application 175 13.7 Conclusions and Future Perspectives 176 Acknowledgments 177 References 177 14 Metabolomics Application in Herbal Medicine 185Wanying Wang, Aihua Zhang, Hui Sun, and Xijun Wang 14.1 Introduction 185 14.2 Metabolomic Dissection of Herbal Medicine 186 14.3 Application in Herbal Medicine 189 14.3.1 Effect Evaluations 189 14.3.2 Mechanism Explorations 192 14.3.3 Quality Control Analyses 193 14.4 Conclusions 194 Acknowledgments 194 References 194 15 Mass Spectrometry-Based Metabolomics Insights into the Mode of Action of Natural Products 199Junling Ren, Aihua Zhang, Hui Sun, and Xijun Wang 15.1 Introduction 199 15.2 Metabolomics: An Overview 200 15.2.1 Comprehensive Metabolomics for Metabolites Detection 200 15.2.2 Understanding Pharmacological Effects 200 15.2.3 Discovery of Biomarkers and Targets 201 15.2.4 Screen Bioactive Natural Products 201 15.3 Superiority of MS-Based Metabolomics 201 15.3.1 Enhanced MS Coverage for Small-Molecule Metabolites 202 15.3.2 MS-Based Metabolomics Guided Biochemical Analysis 202 15.3.3 Identify Molecular Mechanisms by Integrating MS with Databases 202 15.4 Mass Spectrometry Techniques Employed in Metabolomics 202 15.4.1 Gas Chromatography–Mass Spectrometry 203 15.4.2 Liquid Chromatography–Mass Spectrometry 203 15.4.3 Capillary Electrophoresis–Mass Spectrometry 203 15.4.4 Ion Mobility–Mass Spectrometry 204 15.4.5 Mass Spectrometry Imaging 204 15.4.6 New Challenges in MS-Based Metabolomics 204 15.5 Challenges of Natural Products 205 15.6 Herbal Ingredients: Current Research and Applications 205 15.6.1 Various Analytical Strategies for Herbal Ingredients 205 15.6.2 Effective Constituents In Vitro and In Vivo 206 15.7 MS in Natural Product 206 15.7.1 Qualitative Analysis 206 15.7.2 Quantitative Analysis 207 15.7.3 Mechanism Analysis of Action 207 15.8 MS-Based Metabolomics in Bioactive Ingredients 208 15.8.1 Reveal Efficacy of HMs 208 15.8.2 High-Throughput Analysis of HMs 209 15.8.3 Discovery of Quality Markers 209 15.8.4 Toxicity Explorations 211 15.8.5 Potential Impacts on Drug Discovery 211 15.9 Conclusions and Future Perspective 212 Acknowledgment 212 References 213 16 Mass Spectrometry-Driven Lipidomics for Biomarker, Molecular Mechanism, and Therapy 223Qiang Yang, Shi Qiu, Aihua Zhang, and Xijun Wang 16.1 Introduction 223 16.2 Lipidomics Method 223 16.2.1 Targeted Lipidomics 224 16.2.2 Non-targeted Lipidomics 225 16.3 Sample Preparation 225 16.4 Analytical Techniques in Lipidomics 227 16.4.1 Liquid Chromatography–Mass Spectrometry 227 16.4.2 Gas Chromatography–Mass Spectrometry 228 16.4.3 Supercritical Fluid Chromatography–Mass Spectrometry 228 16.4.4 Ion Mobility–Mass Spectrometry 228 16.4.5 Mass Spectrometry Imaging 229 16.4.6 Shotgun Lipidomics 229 16.5 Lipidomics for Biomarker Discovery 229 16.6 Application of MS-Based Lipidomics 230 16.6.1 Efficacy Analysis 230 16.6.2 Food Science 231 16.6.3 Environment 231 16.6.4 Clinical Biomarker Discovery 232 16.6.5 Pharmacological Research 232 16.6.6 Toxicology Analysis 232 16.7 Future Perspectives 233 16.8 Conclusions 234 Acknowledgments 234 References 234 17 Potential Application of Mass Spectrometry-Based Lipidomics for Herbal Medicine 245Ying Cai, Aihua Zhang, Hui Sun, and Xijun Wang 17.1 Introduction 245 17.2 Lipidomics Method 246 17.2.1 Sample Preparation 246 17.2.1.1 Classical Method 246 17.2.1.2 Green Technologies 247 17.2.2 Data Collection and Analysis of Lipidomics 248 17.2.2.1 Untargeted Lipidomics 248 17.2.2.2 Targeted Lipidomics 249 17.2.2.3 Pseudotargeted Lipidomics 249 17.3 Mass Spectrometry Technique in Lipidomics 250 17.3.1 Ionization Technology 250 17.3.2 Mass Analyzer 251 17.3.3 Tandem Mass Spectrometry 252 17.3.4 Ion Mobility–Mass Spectrometry 252 17.3.5 Mass Spectrometry Imaging 253 17.4 Application of Mass Spectrometry-Based Lipidomics for Herbal Medicine 253 17.5 Conclusions 255 Acknowledgments 255 References 255 Index 263

Read more less

Book SynopsisEn esta obra, el doctor De la Fuente, a partir de su vasta experiencia profesional, describe en 60 pasos el MÉtodo de interpretaciÓn clÍnica para problemas complejos que busca facilitar la labor diagnÓstica del mÉdico en su camino de descubrimiento. Con sencillez y profundidad a la vez, el autor ahonda en aspectos estratÉgicos como son la informaciÓn que se tiene que recabar, las preguntas a las que tiene que responder, la forma en la que hay que analizarla, los juicios que hay que hacer, las relaciones que hay que establecer y el cÓmo integrar el resultado final. Todo esto con el objetivo de brindar al paciente un diagnÓstico certero y oportuno de la enfermedad que padece, el cual es indispensable para emprender un tratamiento adecuado.In this work, Dr. De la Fuente shares his medical expertise and describes 60 steps to clinical interpretation that can help facilitate medical diagnoses. The content is both simple and profound, and the author delves into strategies that help medical professionals ask the right questions and properly analyze their patients’ responses. He discusses judgment calls and how to establish a good doctor-patient relationship, all of which aids in achieving positive results. He aims to provide patients with accurate diagnoses, and catching them as early as possible in order to provide the most adequate treatment available.

Read more less

Book Synopsis

Read more less

Book SynopsisConciso, portátil y fácil de usar, Manual Washington de especialidades clínicas. Neumología proporciona acceso rápido a la información esencial necesaria para evaluar a los pacientes con neumopatías. La 2.ª edición ofrece el contenido más actualizado sobre el diagnóstico, la investigación y el tratamiento de las neumopatías agudas y crónicas más comunes, incluyendo la cobertura de tecnologías avanzadas y fármacos más recientes. Ideal para estudiantes de medicina en rotaciones y residentes, el manual también es útil como recurso de primera línea para internistas y otros proveedores de atención primaria. Características principales: Desarrollo ampliado de pruebas diagnósticas y tratamientos Reorganización del formato para una búsqueda rápida y sencilla de la información Información clínica práctica para diagnosticar y tratar a una amplia variedad de pacientes Cobertura integral de asma, EPOC, enfermedad pulmonar intersticial, hipertensión pulmonar, fibrosis quística, infecciones pulmonares, trasplante de pulmón, trastornos respiratorios del sueño y otras afecciones pulmonares comunes Síntomas, signos y problemas encontrados en la práctica diaria en un formato de referencia rápida con viñetas Referencias actualizadas para información adicional sobre un tema en particular. Escrito por becarios y profesores junior de la Facultad de Medicina de la Washington University para abordar de manera efectiva las experiencias clínicas de la vida real

Read more less

Book SynopsisManual Washington® de especialidades clínicas. Endocrinología presenta a los estudiantes de medicina, médicos internos y residentes los principios para la atención de las afecciones que alteran la función endocrina, así como su manejo intrahospitalario y ambulatorio. El texto recoge los principales abordajes para evaluar y tratar al paciente, con el fin de ayudar a perfeccionar las habilidades diagnósticas del lector, darle a conocer un mayor número de opciones terapéuticas y ayudarle a mejorar los resultados del tratamiento. Las secciones centrales tratan temas como la diabetes, la enfermedad tiroidea, y las alteraciones hipofisarias y óseas. Los capítulos sobre la obesidad, la vitamina D, los lípidos el VIH/sida y los síndromes poliglandulares complementan los capítulos principales. Características Principales: Cada capítulo aborda los principios generales, epidemiología, patología, exploración física, opciones de tratamiento y seguimiento Formato tradicional en viñetas para acceder a la información útil de forma rápida y objetiva Contenido revisado y actualizado para reflejar los últimos hallazgos en la fisiopatología y el tratamiento de los trastornos endocrinos Presentación dos colores para una mejor visualización de tablas, gráficos e ilustraciones Perlas clínicas destacadas en negritas, que transmiten información experta recogida por clínicos de amplia experiencia Dosificaciones farmacológicas para mantenerse al día con las últimas indicaciones y estándares

Read more less

Book SynopsisManual Washington. Guía esencial para sobrevivir al internado es una indispensable herramienta con orientación práctica, médica y profesional para los estudiantes que inician el internado. El asesoramiento se presenta en un formato conciso, estructurado con viñetas que permiten una rápida comprensión del material y que les facilitará el aprendizaje básico de los problemas logísticos y la comunicación entre pacientes y colegas, así como los aspectos básicos en las rotaciones clínicas.Características especiales: Punto a punto, explicaciones actualizadas de los 10 diagnósticos más comunes Incluye el historial de claves, lo que no debe olvidar y cuándo pedir ayuda Listas de verificación, con acción útiles que no debe pasar por alto Incluye lo que se debe hacer y lo que no se puede hacer, como la admisión y el alta de pacientes y la comunicación con otros miembros del equipo médico Los temas médicos cubren la seguridad del paciente, la mitigación de riesgos, la gestión de fluidos, el funcionamiento de dispositivos comunes como los electrocardiogramas (ECG), así como una descripción general de las principales especialidades clínicas

Read more less

Book SynopsisManual Washington de especialidades clínicas. Enfermedades infecciosas ofrece el contenido más avanzado sobre diagnóstico, investigación y tratamiento de una larga variedad de enfermedades infecciosas. Es la referencia principal para estudiantes de medicina, internos, residentes y otros practicantes que necesitan tener acceso rápido a información clínica práctica para diagnosticar y tratar a pacientes con este tipo de afecciones. El campo de las enfermedades infecciosas es excitante y está en constante evolución. Desde la publicación de la última edición de este manual han surgido nuevas enfermedades, nuevos métodos de diagnóstico y nuevos desafíos en el tratamiento con el desarrollo de organismos resistentes a múltiples fármacos. Por ello, esta 3.ª edición ha sido actualizada con patógenos de nueva aparición, diagnósticos moleculares rápidos y nuevas estrategias terapéuticas preventivas. Asimismo, se han añadido dos capítulos sobre la optimización antimicrobiana, los arbovirus y las fiebres hemorrágicas.

Read more less

Book SynopsisManual Washington® de especialidades clínicas: Nefrología presenta a los estudiantes de medicina, médicos internos y residentes los principios para la atención de las afecciones que alteran la función renal, así como su manejo intrahospitalario y ambulatorio. El texto recoge, en el popular formato de la serie Washington®, los principales abordajes para evaluar y tratar a los pacientes, con el fin de ayudar a perfeccionar las habilidades diagnósticas del lector, darle a conocer un mayor número de opciones terapéuticas y ayudarle a mejorar los resultados del tratamiento. En los distintos capítulos de esta 4.ª edición se cubren el abordaje general de las enfermedades renales, las alteraciones electrolíticas y acidobásicas, las lesiones renales agudas, el tratamiento de depuración extrarrenal continua, las causas de la enfermedad renal, el embarazo y la nefrolitiasis, y la enfermedad renal crónica.

Read more less

Book SynopsisWallach. Interpretación clínica de pruebas diagnósticas 11 edición, continúa siendo un excelente recurso para ordenar e interpretar las pruebas clínicas de manera adecuada, rápida y efectiva para lograr un diagnóstico preciso. En un formato portable y con una estructura fácil de usar este manual completamente revisado proporciona información práctica sobre estados de enfermedades comunes y poco comunes y su diagnóstico mediante pruebas de laboratorio.   El objetivo principal de este libro es enfatizar el uso más preciso y eficiente de las pruebas de laboratorio clínico. En el primer capítulo se incluye una amplia tabla de las pruebas ordenadas con mayor frecuencia. En el segundo se encuentran las pruebas clínicas ordenadas alfabéticamente con la misma estructura: definición, uso, interpretación y limitaciones. Los siguientes capítulos detallan las pruebas en enfermedades infecciosas, enfermedades autoinmunes, trastornos cardiovasculares, enfermedades del sistema nervioso central, enfermedades digestivas, enfermedades endocrinas, desordenes del sistema genitourinario, trastornos ginecológicos y obstétricos, hemopatías, enfermedades hereditarias y genéticas, enfermedades infecciosas, enfermedades renales, trastornos respiratorios, metabólicos y acidobásicos, toxicología y vigilancia farmacológica, medicina de transfusión.  Como en ediciones anteriores, este libro está dirigido a médicos de atención primaria, subespecialistas, residentes, enfermeras practicantes y estudiantes de medicina y enfermería.

Read more less

Book SynopsisManual Washington® de especialidades clínicas: Gastroenterología presenta a médicos residentes de gastroenterología y a estudiantes de medicina en rotaciones clínicas los principios para la atención de las afecciones que alteran la función gastrointestinal, así como su manejo intrahospitalario y ambulatorio. El texto recoge, en el popular formato de la serie Washington®, los principales abordajes para evaluar y tratar a los pacientes, con el fin de ayudar a perfeccionar las habilidades diagnósticas del lector, darle a conocer un mayor número de opciones terapéuticas y ayudarle a mejorar los resultados del tratamiento.Los distintos capítulos de esta 4.ª edición, redactados por especialistas de la Washington University, se dividen en dos amplias secciones. La primera aborda la sintomatología más frecuente de los problemas digestivos (disfagia, náusea y vómito, diarrea, estreñimiento, etc.). En la segunda sección se cubren las afecciones gastrointestinales más frecuentes organizadas por región anatómica.

Read more less