Maturation and ageing Books
HarperCollins Publishers Whisky Made Me Do It
Book Synopsis60 wonderful whisky and bourbon cocktails
£12.34
Oxford University Press, USA Engineering the Human Germline An Exploration of the Science and Ethics of Altering the Genes We Pass to Our Children
Book SynopsisThis book gives an overview of the potential and the practical details that need to be resolved to make human germline engineering possible. Chapters present the ethical and social concerns and implications of the fast-approaching capability to alter the human germline and take an active role in the future evolution of the species.Trade ReviewThe book should be commended for bringing to the fore the possibilityof germline manipulation within the next decade * New Genetics & Society *...interesting reading. * Heredity *The participants, mostly drawn from Us academic institutions, fall into three categories: eminent practising scientists; panelists, including James Watson, the co-discoverer of the structure of DNA; and commentators- scientists, ethcicists and theologians * Nature *Table of ContentsSection One ; 1. A vision for human germline engineering ; 2. The human genome project - launch pad for human genetic engineering ; 3. Ethics and Safety ; 4. Human germline gene therapy: how and why ; 5. A new front in the battel against disease ; 6. Aging as a target for genetic engineering ; 7. Reprogenetics: how reproductive and genetic technolgies will be combined to provide new opportunities for people to reach their reproductive goals ; Section Two ; Panel: The road ahead ; Section Three"R ; 1. Other voices - Introduction ; 2. Parental choices ; 3. Thoughts on the... ; 4. The psycho-social limits on human germline modification ; 5. Do we know ourselves well enough to be engineering humans? ; 6. Germline manipulation ; 7. Maximize parental choice ; 8. Our societal obligations for keeping human nature untouched ; 9. The question of purpose ; 10. Gene modification technology ; 11. Justice and the germline ; 12. Human germ line intervention: What's the fuss about? ; 13. Germline culture: The genetics of hubris ; 14. Liberty, equality, and solidarity in our genetically engineered future ; 15. Would humanity be better off...Or, what would it be better for? ; 16. Human dignity should not keep us from genetically engineering our children ; 17. Universal bioethics for the human germline ; 18. Multi-jurisdiction regulation of germline intervention 'A policy with neither virtue nor prospect of success ; Section 4. Chapter Contributors and Essay Contributors
£41.79
Cognella, Inc Understanding Communication and Aging: Developing Knowledge and Awareness
Book SynopsisThis book explores communication in older adulthood, particularly in the areas of interpersonal, intercultural, and mass communication, and includes coverage of communication using new technology. The book synthesises existing research and builds a case for more positive attitudes towards aging and for the power of communication to shape such attitudes.A succinct mix of the conceptual and the practical, the authors acknowledge the importance of theory yet also emphasise that communication and aging is inherently an applied field of study. Chapters include profiles of older adults and their significant achievements, literary and artistic depictions of aging, and information boxes that discuss myths about aging and keys to aging successfully. There are also numerous exercises and activities to help engage readers.While retaining the structure of previous editions, the content of this version has been substantially updated, including the addition of the Communicative Ecology Model of Successful Aging (CEMSA) in Chapter 4. The authors provide enhanced coverage of diversity of race, culture, age, and sexual orientation as well as more diverse ways of "doing aging." There is also more focus in this edition on older adults' romantic lives, spirituality, and their use of media and technology.Forward thinking in approach and coverage, this book is ideal for courses in communication, gerontology, nursing, and family studies.
£76.00
Little, Brown & Company Aging Well
Book SynopsisSurprising guideposts to a happier life from the landmark Harvard Study of Adult DevelopmentTrade ReviewA smart, important book about human development....everything about it is profoundly, provocatively new. * SAN FRANCISCO Chronicle *
£14.24
Hachette Australia Prime Time
Book SynopsisHit podcast host and bestselling author of How to Have an Epic Retirement Bec Wilson presents the ultimate guide to modern midlife. We're now living longer, saving smarter, working more flexibly and seeking more meaning. Bec guides you in 27 practical lessons on money, health, work, purpose, family and travel, so you can make your Prime Time count.
£15.19
Headline Publishing Group Whos That Woman in the Mirror The Art of Ageing
Book Synopsis''Age is irrelevant, unless you happen to be a bottle of wine'' Joan CollinsKeren Smedley is passionate about altering outdated stereotypes about age and helping people to change their beliefs and attitudes to ageing. As a professional life coach - for Saga among other organizations - she has been asked every kind of question you could imagine, and some you couldn''t, about the uncertainties and problems of today''s baby boomer. Whether it''s about sexuality, money, relationships, health, friends, planning for the future, the best selection of those questions is contained here in WHO''S THAT WOMAN IN THE MIRROR? You will be impressed by the wisdom of the answers - and the endless variety of the questions. Like an extended problem page for baby boomers, this book will inform as it entertains.
£10.99
Taylor & Francis Inc Aging is a GroupSelected Adaptation
Book SynopsisAlthough books exist on the evolution of aging, this is the first book written from the perspective of again as an adaptive program. It offers an insight into the implications of research on aging genetics, The author proposes the Demographic Theory of Senescence, whereby aging has been affirmatively selected because it levels the death rate over time helping stabilize population dynamics and prevent extinctions.Table of ContentsIntroduction. Hormesis. The Diverse Demography of Aging. Aging is not caused by accumulated damage. Three Prevailing Theories, and Their Failings. Aging is Very Old. Population Control. How Might Aging Have Evolved as an Adaptation? Implications and Directions. A New Paradigm for Medical Research.
£99.75
Pan Macmillan Australia Staying Alive
Book Synopsis
£17.99
Bonnier Books Ltd The Joy of Big Knickers: (or learning to love the
Book SynopsisThe Sunday Times Top Ten BestsellerTV and radio presenter Kate Garraway has a lot on her mind. She's turned 50, and suddenly seems to have MANY questions about EVERYTHING. Should she get plastic surgery? Will the menopause ruin her life? What's the secret to making love last? Can anyone really deal with the idea of death? And why, oh why, did nobody tell her how important big knickers would be?! As she tries to find what's useful amongst the deluge of advice we are bombarded with, Kate discovers a lesson on why women in their midlife and beyond should be loved and celebrated, especially by themselves...
£8.54
John Wiley & Sons Inc Protein Oxidation and Aging
Book SynopsisAs the lifespan of humans increases, research into aging and its related pathological conditions is gaining momentum. This book is the first to explain protein oxidation and the aging process, focusing on the connection between protein disturbances and the oxidative stress that cells continually undergo.Trade Review“With its discussion of current concepts linked to protein oxidation and its impact on aging and the pathology of certain age-related diseases, this book is an important contribution to the field. Students, researchers, scientists, and even clinicians will benefit from it.” (Doody’s, 10 January 2013) “The format and compartmentalised writing style make this an excellent compendium of knowledge for any researcher interested in assessing our state of knowledge of protein oxidation and ageing. It is easy to find out about the current state of knowledge about a specific reaction, product, method, and/or disease and follow this up by accessing the extensive list of references.” (Chemistry & Industry, 1 July 2013)Table of ContentsIntroduction to the Wiley Series on Protein and Peptide Science xi Preface xiii 1 Oxidative Stress and Protein Oxidation 1 1.1 The Large Variety of Protein Oxidation Products, 7 1.1.1 Primary Protein Oxidation Products, 7 1.1.1.1 Carbon-Centered Radicals, 9 1.1.1.2 Thiyl Radicals, 13 1.1.1.3 Aromatic Ring-Derived Radicals, 13 1.1.1.4 Transfer between Sites, 16 1.1.2 Reactive Compounds Mediating in Protein Oxidation, 18 1.1.2.1 Hydroxyl Radical, 20 1.1.2.2 Superoxide Radicals, 21 1.1.2.3 Hydrogen Peroxide, 24 1.1.2.4 Lipid Peroxyl Radicals, 24 1.1.2.5 Alkoxyl Radicals, 24 1.1.2.6 •NO and Peroxynitrite, 25 1.1.2.7 Hypochlorous Acid, 30 1.1.3 Enzymatic Systems Playing a Role in Protein Oxidation, 31 1.1.3.1 NADPH Oxidase, 32 1.1.3.2 Lipoxygenases, 35 1.1.3.3 Protein Kinases, 35 1.1.3.4 Mixed-Function Oxidases, 36 1.1.3.5 Nitric Oxide Synthetase (NOS), 38 1.1.3.6 Myeloperoxidase, 41 1.1.3.7 Cyclooxygenase, 42 1.1.4 Protein Oxidation in Cells and Cellular Structures, 43 1.1.4.1 Protein Oxidation in Blood and Blood Cells, 43 1.1.4.2 Protein Oxidation of Glycolytic Enzymes and Mitochondria, 46 1.1.4.2.1 Glycolytic Enzymes, 48 1.1.4.2.2 Aconitase, 49 1.1.4.2.3 Carnitine Palmitoyltransferase-1, 49 1.1.4.3 Cytochrome P450 Enzymes, 49 1.1.4.4 Protein Oxidation in the Nucleus and Chromatin, 50 1.1.4.4.1 Histone Modifi cation, 50 1.1.4.5 Protein Oxidation in the Endoplasmic Reticulum, 52 1.1.4.6 Protein Oxidation in Peroxisomes, 54 1.2 Reversible Oxidative Modifi cations, 55 1.2.1 Methionine Sulfoxides and Methionine Modifi cations, 55 1.2.2 Cysteine Modifi cations and Disulfi de Bond Formation, 61 1.2.3 Surface Hydrophobicity Modifi cations, 64 1.3 Irreversible Oxidation Products, 64 1.3.1 Protein Oxidation and Enzymatic Posttranslational Modifications, 65 1.3.2 Deamidation and Transamination, 66 1.3.3 Protein Glycation and AGEs, 67 1.3.3.1 Receptor for Advanced Glycation End Products (RAGE), 75 1.3.3.2 Nε-Carboxymethyllysine and Nε-Carboxyethyllysine, 76 1.3.3.3 Pentosidine, 76 1.3.4 Racemization, 77 1.3.5 Nitrosylation, 77 1.3.6 Tyrosyl Radicals and Nitrotyrosines, 78 1.3.6.1 Dityrosines, 79 1.3.7 Protein Carbonyls, 80 1.3.8 Aldehyde–Protein Reactions, 81 1.3.8.1 MDA-Protein Adducts, 82 1.3.8.2 4-Hydroxy-2,3-Nonenal-Protein Adducts, 82 1.3.9 Cross-Linking of Proteins, 82 1.4 The Oxidation of Extracellular Matrix, Membrane and Cytoskeletal Proteins, 83 1.4.1 Collagen, 84 1.4.2 Elastin, 95 1.4.3 The Oxidation of Membrane Proteins, 97 1.4.4 Band 3, 97 1.4.5 Actin, 99 1.5 Mechanism and Factors Influencing the Formation of Protein Oxidation Products, 100 1.5.1 Redox Status, 101 1.5.2 Protein Turnover, 106 1.5.3 Metal-Catalyzed Oxidation (MCO), 107 1.5.4 Heat Shock Proteins, 109 1.6 Protein Aggregates: Formation and Specific Metabolic Effects, 111 1.6.1 Accumulation of Oxidized Proteins, 113 1.6.2 Lipofuscin and Ceroid, 115 1.7 Methods to Measure Protein Oxidation Products in Research Laboratories, 119 1.7.1 Determination of Methionine Sulfoxide Reduction and Methionine Oxidation, 120 1.7.2 Determination of Protein Glycation and Adducts, 121 1.7.3 Analysis of Isoaspartate Formation, 122 1.7.4 Measurement of Fragmentation, 122 1.7.5 Measurement of Tyrosine Oxidation, 123 1.7.6 Protein Carbonyl Measurement, 124 1.7.7 Radioactive Labeling Protocols for Proteolysis and Aggregation Measurements, 128 1.7.8 Standard Chromatographic Methods for the Measurement of Protein Modifi cations, 132 1.7.9 Liquid Chromatography Techniques Supported by Mass Spectrometry, 133 1.7.10 GC/MS, 134 1.7.11 Analysis of Protein-Bound 3-Nitrotyrosine by a Competitive ELISA Method, 134 1.7.12 Protein Oxidation Products as Biomarkers in Clinical Science, 135 References, 139 2 Removal of Oxidized Proteins 215 2.1 The Limited Repair of Some Oxidized Proteins, 216 2.1.1 Thiol Repair, 216 2.1.2 Methionine Sulfoxide Reductases, 219 2.2 Proteolysis, 221 2.2.1 The Proteasomal System and Its Role in the Degradation of Oxidized Proteins, 222 2.2.1.1 The Ubiquitin–Proteasome System (UPS), 222 2.2.1.2 The Components of the UPS, 222 2.2.1.2.1 The 20S Proteasome, 222 2.2.1.2.2 The Inducible Forms of the Proteasome and Their Function, 227 2.2.1.2.3 The 11S Regulator, 231 2.2.1.2.4 The 19S Regulator and the UPS, 233 2.2.1.2.5 The PA200 Regulator Protein, 238 2.2.1.2.6 Cellular Proteasome Inhibitors, 239 2.2.1.3 Low-Molecular-Weight Proteasome Inhibitors, 239 2.2.1.4 Cellular Function of the UPS, 241 2.2.1.5 The Degradation of Oxidized Proteins: A Function of the 20S Proteasome, 243 2.2.1.5.1 Early Studies on the Turnover of Oxidized Proteins, 244 2.2.1.5.2 In Vitro Studies and the Recognition of Oxidized Proteins by the Proteasome, 244 2.2.1.5.3 Cellular and In Vivo Studies of the Degradation of Oxidized Proteins, 248 2.2.1.5.4 The Inhibition of the Proteasome by Cross-Linked Oxidized Proteins and Proteasomal Regulation during Oxidative Stress, 251 2.3 The Role of Other Proteases in the Fate of Oxidized Proteins, 254 2.3.1 Lysosomal Degradation of Oxidized Proteins and the Role of Autophagy, 254 2.3.2 Mitochondrial Degradation of Oxidized Proteins and the Lon Protease, 256 2.3.3 The Uptake of Extracellular Oxidized Proteins and the Role of the Proteasome in Their Degradation, 258 2.3.4 Calpains and the Degradation of Oxidized Proteins, 259 2.4 Role of Heat Shock Proteins in Protein Degradation, 260 2.5 Conclusion, 262 References, 262 3 Protein Oxidation and Aging: Different Model Systems and Affecting Factors 295 3.1 Protein Oxidation during Aging: Lower Organisms and Cellular Model Systems, 297 3.1.1 Yeast, 297 3.1.1.1 Saccharomyces cerevisiae, 297 3.1.1.2 Schizosaccharomyces pombe, 301 3.1.2 Podospora anserina, 301 3.1.3 Bacteria, 302 3.1.3.1 Escherichia coli, 302 3.1.4 Cell Cultures, 304 3.2 Nonmammalian Model Systems and the Accumulation of Oxidized Proteins during Aging, 308 3.2.1 Caenorhabditis elegans, 308 3.2.2 Drosophila melanogaster, 310 3.2.3 Aquatic Systems, 313 3.2.4 Plants, 315 3.2.5 Amphibians, 317 3.3 Age-Related Protein Oxidation in Humans and Mammals, 317 3.3.1 Humans, 317 3.3.2 Animals, 319 3.3.2.1 Rabbits, 323 3.3.2.2 Mice, 324 3.3.2.3 Rats, 327 3.3.2.4 Gerbils, 329 3.3.2.5 Primates, 330 3.4 Inherited Factors Influencing Protein Oxidation during Aging, 331 3.4.1 Genetic Instability, Mutations, and Polymorphism, 331 3.4.2 Gender, 333 3.4.3 Vitagenes, 334 3.4.4 Signal Transduction and Transcription Factors, 335 3.4.5 Ion Channels, 340 3.5 Age-Related Protein Aggregate Formation in Model Systems, 341 3.6 Environmental Factors Affecting Healthy Aging, 342 3.6.1 UV-Induced Skin Photoaging and Skin Aging, 344 3.6.2 Pesticides, 348 3.6.3 Exercise, 349 3.6.4 Dietary Factors and Prevention Strategies, 351 3.6.4.1 Melatonin, 353 3.6.4.2 Growth Hormone, 354 3.6.4.3 Biotrace Metal Elements: Zinc, 356 3.6.4.4 Ascorbic Acid, 357 3.6.4.5 Vitamin E, 360 3.6.4.6 Carnitine and Acetyl-L-Carnitine, 361 3.6.4.7 Homocysteine, 362 3.6.4.8 Ubiquinone, Coenzyme Q10, 363 3.6.4.9 Carnosine, 363 3.6.4.10 Lipoic Acid, 364 3.6.4.11 N-Acetyl-L-Cysteine, 365 3.6.5 Pharmacological Response and Biotransformation in Aging, 365 3.6.5.1 Plant Extracts, 366 3.6.5.2 Polyphenols and Flavonoids, 366 3.6.5.3 Resveratrol, 367 3.6.5.4 AGE and ALE Inhibitors, 368 3.6.6 Caloric Restriction, 369 3.7 Repair and Degradation of Oxidized Proteins during Aging, 370 References, 372 4 Protein Oxidation in Some Age-Related Diseases 417 4.1 Protein Oxidation during Neurodegeneration and Neurological Diseases, 417 4.1.1 Brain Aging, 418 4.1.2 Alzheimer’s Disease, 420 4.1.3 Parkinson’s Disease, 424 4.1.4 Huntington’s Disease, 425 4.1.5 Stroke, 427 4.1.6 Amyotrophic Lateral Sclerosis, 427 4.2 Protein Oxidation in Cardiac Diseases, 429 4.2.1 Ischemia–Reperfusion, 429 4.2.2 Atherosclerosis, 430 4.3 Protein Oxidation in Diabetes, 431 4.4 Protein Oxidation in Degenerative Arthritis, 434 4.5 Protein Oxidation in Muscle Wasting and Sarcopenia, 435 4.6 Protein Oxidation in Destructive Eye Diseases, 437 4.6.1 Age-Related Macular Degeneration, 437 4.6.2 Cataract, 438 4.7 Protein Oxidation in Osteoporosis, 440 4.8 Protein Oxidation in Cancer, 441 4.8.1 Proteasome Inhibitors in Cancer Therapy, 444 4.9 Other Diseases, 446 4.9.1 Premature Aging Diseases Progeria and Werner’s Syndrome, 446 4.9.2 Renal Failure and Hemodialysis in Elderly People, 447 4.9.3 Obesity, 447 4.9.4 Idiopathic Pulmonary Fibrosis, 448 4.9.5 Presbycusis (Age-Related Hear Loss), 448 References, 448 List of Abbreviations 479 Index 493
£135.80
Rutgers University Press Our Aging Bodies
Book SynopsisProvides a clear, scientifically based explanation of what happens to all the major organ systems and bodily processes - such as the cardiovascular and digestive systems - as people age. Throughout the book, Gary F. Merrill weaves in personal anecdotes and stories that help clarify and reinforce the facts and principles of the underlying scientific processes and explanations.Trade Review"Professor Merrill has written an important book on how various parts of the body change with aging. He has taught human systems physiology for some forty years and is very knowledgeable. An important 'take-home' message is that we can live a longer, healthier life if we treat our bodies carefully, and he tells us what we have to do. A point he makes is that many new medications advertised to treat various symptoms should be taken with caution. An expert on the inflammatory response, he discusses its negative impact on aging." -- David Denhardt * professor emeritus of Cell Biology and Neuroscience, Rutgers University *"Gary F. Merrill, a professor of cell biology and neuroscience at Rutgers University, presents abundantly fascinating scientific information about the human aging process. Written for a lay audience, this book describes in detail the adverse effects of unhealthy choices on human longevity. Our Aging Bodies explains how the human body develops, matures, ages, and declines and will benefit those interested in improving their health, well-being, and longevity." * Foreword Reviews *"A book that will pique the interest of those seeking to know about the human aging process … Highly recommended." * CHOICE *"Rutgers University cardiovascular physiologist Merrill authoritatively spells out how getting older changes the body’s major organs. This veteran of four decades of teaching sprinkles his informative guide with fascinating tidbits. A recurring theme: stay slim and don’t overeat, because restricting calories appears to extend longevity. Merrill [offers] a good, scientifically sound addition to the growing number of books on aging." * Booklist *"Professor Merrill has written an important book on how various parts of the body change with aging. He has taught human systems physiology for some forty years and is very knowledgeable. An important 'take-home' message is that we can live a longer, healthier life if we treat our bodies carefully, and he tells us what we have to do. A point he makes is that many new medications advertised to treat various symptoms should be taken with caution. An expert on the inflammatory response, he discusses its negative impact on aging." -- David Denhardt * professor emeritus of Cell Biology and Neuroscience, Rutgers University *"A book that will pique the interest of those seeking to know about the human aging process … Highly recommended." * CHOICE *"Gary F. Merrill, a professor of cell biology and neuroscience at Rutgers University, presents abundantly fascinating scientific information about the human aging process. Written for a lay audience, this book describes in detail the adverse effects of unhealthy choices on human longevity. Our Aging Bodies explains how the human body develops, matures, ages, and declines and will benefit those interested in improving their health, well-being, and longevity." * Foreword Reviews *"Rutgers University cardiovascular physiologist Merrill authoritatively spells out how getting older changes the body’s major organs. This veteran of four decades of teaching sprinkles his informative guide with fascinating tidbits. A recurring theme: stay slim and don’t overeat, because restricting calories appears to extend longevity. Merrill [offers] a good, scientifically sound addition to the growing number of books on aging." * Booklist *Table of ContentsTable of Contents 1 How We Age2 The Aging Nervous System3 The Aging Endocrine System4 The Aging Immune System5 The Aging Reproductive System6 The Aging Urinary System7 The Aging Gastrointestinal System8 The Aging Musculoskeletal System9 The Aging Cardiovascular System10 The Aging Respiratory System
£25.19
John Wiley and Sons Ltd The Encyclopedia of Adulthood and Aging 3 Volume
Book Synopsis This authoritative reference work contains more than 300 entries covering all aspects of the multi-disciplinary field of adult development and aging Brings together concise, accurate summaries of classic topics as well as the most recent thinking and research in new areas Covers a broad range of issues, from biological and physiological changes in the body to changes in cognition, personality, and social roles to applied areas such as psychotherapy, long-term care, and end-of-life issues Includes contributions from major researchers in the academic and clinical realms 3 Volumes www.encyclopediaadulthoodandaging.comTrade Review"This three-volume encyclopedia set includes a diversity of topics focused on the understanding the physical, mental, and social aspects of aging adults.....the set will serve well as a desk reference for professionals and is an up-to-date addition to academic library reference collections." (Choice Connect 2016)Table of ContentsVolume IAlphabetical List of Entries viiThematic List of Entries xiiiAbout the Editors xixContributors xxiiiIntroduction xcviiAdulthood and Aging A–Volume IIAdulthood and Aging –Volume IIIAdulthood and Aging –ZIndex
£422.10
John Wiley and Sons Ltd Mental Health Intellectual Disabilities and the
Book SynopsisMental Health, Intellectual Disabilities, and the Aging Process Edited by Philip W. Davidson, Vee P. Prasher and Matthew P. Janicki This book is the third in a series with the International Association for the Scientific Study of Intellectual Disabilities (Series Editor: Matthew P. Janicki).Table of ContentsOverview of Aging, Emotional Health and Behaviour. Section I: Prevalence and Diagnosis. Prevalence of Mental, Behavioural and Neurobehavioral Disorders among Older People with Intellectual Disabilities. Psychopathology and Older Age. General Etiological Issues. Assessment of Behavioural and Psychiatric Disorders. Depression in Adults and Aging Individuals with Intellectual Disabilities. Cognitive Decline and Aging. Behavioural and Psychiatric Overlays from Physical and Medical Conditions. Emotional Health and Aging in Adults with Down Syndrome. Section II Treatments and Interventions. Psychotherapy and Other Psychological Interventions. Aging-Related Behavioural Interventions. Psychotropic Medications. Dynamics of Bereavement and Grief Reactions. Section III Service System Issues. Community Mental Health and Support Services: Planning Principles and Models. Prevention Strategies and Community Education. Future Directions and Challenges
£55.05
Edward Elgar Publishing Ltd State and Local Retirement Plans in the United
Book SynopsisState and Local Retirement Plans in the United States explains how economic and political events have shaped the development of pension plans in the last century, and it argues that changes in the structure and generosity of these plans will continue to shape policy and funding in the future. It also brings to bear a new rationale to the policies behind public sector pension plans. The authors use the history of how early public pension plans were established, how they matured and how they have grown in generosity to analyse what changes may be expected in years to come. Unique in its scope, this comprehensive history of the development of public sector pension plans in the United States during the twentieth century expands upon current ideas relating to the changing economic environment, the passage and evolution of social security and the expansion of the public sector. With the exception of military pension plans, which date from the eighteenth century, the first public sector plans, dating from the late nineteenth century, were established to cover teachers, police officers and firefighters in large cities. Over time, these retirement plans were extended to other public sector workers and the local plans were often merged with plans for state workers; all of these date from the twentieth century. Here, the authors show just how pension coverage for public sector workers expanded steadily, through the first half of the twentieth century, so that by the 1960s the vast majority of public sector workers were covered by a plan. This analysis demonstrates how economic events and shifts in public policy at the federal, state and local levels helped to shape public sector retirement plans. The authors also compare public plans with private sector plans, and the final chapter focuses on recent changes in public pensions in response to the `Great Recession', concurrent sharp declines in equity markets and the aging of the public workforce. Scholars and students of economics, history and public policy, public administrators, policymakers and all those with an interest in policy development will find the analyses discussed and conclusions drawn here of significance.Trade Review‘In their recent book State and Local Retirement Plans in the United States, authors Robert L. Clark, Lee A. Craig and John Sabelhaus have provided a valuable and comprehensive history of the development of public pension plans in the 20th century. . . this book represents an important contribution to economists’ historical understanding of state and local pension plans, and I learned a great deal from reading it.’ -- Joshua Rauh, Journal of Pension Economics and Finance‘This book provides a fine source for further research and public discussions about state and local government pension programs. Highly recommended.’ -- J.L. Mikesell, ChoiceTable of ContentsContents: 1. Public Pension Plans in the Twentieth Century 2. Public Sector Pension Plans on the Eve of the Great Depression 3. State and Local Pension Plans During the Great Depression 4. State and Local Pension Plans and the Evolution of Social Security: 1940–1975 5. Pension Plans for Public School Teachers 6. Maturing State Pension Plans: 1975–2000 7. Maturing Local Pension Plans: 1975–2000 8. Comparing Trends in Public Pensions to Those in the Private Sector 9. Financial Status of Public Sector Retirement Plans 10. Public Pensions in the Twenty-first Century References Index
£94.00
Springer International Publishing AG Biochemistry and Cell Biology of Ageing: Part III
Book SynopsisThis book provides a state-of-the-art overview of key areas of subcellular aging research in human cells. The reader is introduced to the historical development and progress in biomedical aging research and learns, for example, about the role of microRNAs, circRNAs, mitochondria and extracellular vesicles in cellular senescence. The reader will also learn more about how gap junctions, the nuclear pore complex and the proteasome are affecting the ageing processes. In addition, novel therapeutic opportunities through modulation of cellular senescence are discussed. The book follows on from Parts I and II of Biochemistry and Cell Biology of Ageing (Volumes 90 and 91 of the Subcellular Biochemistry book series) by covering interesting and significant biomedical ageing topics not included in the earlier volumes. Comprehensive and cutting-edge, this book is a valuable resource for experienced researchers and early career scientist alike, who are interested in learning more about the fascinating and challenging question of why and how our cells age.Table of ContentsSee Attachments
£142.49
Springer International Publishing AG Artificial Intelligence for Healthy Longevity
Book SynopsisThis book reviews the state-of-the-art efforts to apply machine learning and AI methods for healthy aging and longevity research, diagnosis, and therapy development. The book examines the methods of machine learning and their application in the analysis of big medical data, medical images, the creation of algorithms for assessing biological age, and effectiveness of geroprotective medications.The promises and challenges of using AI to help achieve healthy longevity for the population are manifold. This volume, written by world-leading experts working at the intersection of AI and aging, provides a unique synergy of these two highly prominent fields and aims to create a balanced and comprehensive overview of the application methodology that can help achieve healthy longevity for the population.The book is accessible and valuable for specialists in AI and longevity research, as well as a wide readership, including gerontologists, geriatricians, medical specialists, and students from diverse fields, basic scientists, public and private research entities, and policy makers interested in potential intervention in degenerative aging processes using advanced computational tools. Table of ContentsAI in longevity.- Automated reporting of medical diagnostic imaging for early disease and aging biomarkers detection.- Risk forecasting tools based on the collected information for two types of occupational diseases.- Obtaining longevity footprints in DNA methylation data using different machine learning approaches.- The role of assistive technology in regulating the behavioural and psychological symptoms of dementia.- Epidemiology, genetics and epigenetics of Biological Aging: one or more aging systems?.- Temporal relation prediction from Electronic Health Records using Graph Neural Networks and Transformers Embeddings.- In silico screening of life-extending drugs using machine learning and omics data.- An overview of kernel methods for identifying genetic association with health-related traits.- Artificial Intelligence approaches for skin anti-aging and skin resilience research.- AI in genomics and epigenomics.- The utility of information theory based methods in the research of aging and longevity.- AI for Longevity: getting past the Mechanical Turk model will take Good Data.- Leveraging algorithmic and human networks to cure human aging: Holistic understanding of Longevity via Generative Cooperative Networks, Hybrid Bayesian/Neural/Logical AI and Tokenomics-Mediated Crowdsourcing.
£151.99
Taylor & Francis Ltd The Menstrual Cycle Women and Psychology
a huge range and FREE tracked UK delivery on ALL orders.
£37.99
Cambridge University Press The Biology of Human Ageing 25 Society for the Study of Human Biology Symposium Series Series Number 25
a huge range and FREE tracked UK delivery on ALL orders.
£33.24
Cambridge University Press Human Senescence Evolutionary and Biocultural Perspectives 36 Cambridge Studies in Biological and Evolutionary Anthropology Series Number 36
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£36.87
Cambridge University Press Human Senescence Evolutionary and Biocultural Perspectives 36 Cambridge Studies in Biological and Evolutionary Anthropology Series Number 36
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£120.65
Cambridge University Press The Clock of Ages
a huge range and FREE tracked UK delivery on ALL orders.
£41.79
Hay House Inc Beyond Longevity
Book Synopsis
£16.14
