Manufacturing industries Books

Book SynopsisTable of Contents1. What is Pharmacology? 2. How Different Tissues Process Drug Response 3. Drug–Receptor Theory 4. Pharmacological Assay Formats: Binding 5. Drug Targets and Drug-Target Molecules 6. Agonists: The Measurement of Affinity and Efficacy in Functional Assays 7. Orthosteric Drug Antagonism 8. Allosteric Modulation 9. The Optimal Design of Pharmacological Experiments 10. Pharmacokinetics 11. Safety Pharmacology 12. The Drug Discovery Process 13. Selected Pharmacological Methods

Read more less

Book SynopsisThe years since the global financial crisis have seen something of a renaissance in the manufacturing industry. The United States has launched its Advanced Manufacturing Partnership, and China owes much of its spectacular economic boom in the last decades to its being the ''world''s factory''. Is there room for the EU in this landscape? This timely new book explores Europe's role in this evolving environment. It argues that on the one hand, in terms of sheer numbers, the role of the manufacturing industry in the EU is on a par with other major global economies. However, the book also states that Europe falls short of its global competitors (the USA in particular) in terms of its involvement in the most innovative manufacturing sectors. The volume therefore argues that this creates the opportunity for a new European industrial policy. Exploring the development of current EU policy, the book puts forward suggestions as to how the EU can improve in terms of the competitiveness of its tTrade Review"I think the book by Franco Mosconi can contribute to raise the awareness of the urgency of such line of policy. It gathers all the most important documents and position papers by the EU and other sources dealing with the issue; it offers a relevant statistical background in support of the arguments developed and, above all, it makes a good reading, clear and complete, for anyone who needs or wants to be acquainted with the matter."Professor Vera Zamagni, University of Bologna and Johns Hopkins University Bologna Center"This book provides a thorough overview of the European Union’s industrial and technology policies. Based on a empirical approach with relevant examples and figures, the author analyzes how European industrial champions have emerged. It also outlines the various tools that have been developed by the European authorities with the aim of fostering competitiveness and innovation capacities. A timely and essential book on a strategic issues concerning the future of Europe."Jean-Christophe Defraigne, Professor of Economics, Institute for European Studies & Louvain School of Management, UCLouvain Saint-Louis Bruxelles"The New European Industrial Policy is a readily accessible, clear and compelling argument about the connections between EU policy, state responses, and the manufacturing industries. As Franco Mosconi explains, governmental support and policies (both at EU- and state-level) matter in shaping the productive capacities of states. In particular, the book provides an excellent explanation for the rise of European Champions in the Single Market, as well as for the resilience of SMEs."Hiroshi Nakazato, Associate Professor of the Practice in International Studies and Associate Director of the International Studies Program, Boston College"At a time when industrial policy is once again a focus of policy agendas globally, this book comparatively analyses the situation in Europe from both theoretical and practical angles. One of the foremost experts in the field, Franco Mosconi, puts European industrial policy in perspective vis-à-vis competition from the USA and East Asia."Murat Yülek, Rector, OSTIM Technical University, AnkaraTable of ContentsI. The New European Industrial Policy: An Overview II. The New European Oligopoly: The Role of the "European Champions" III. Industrial Policy and "Models of Capitalism" IV. Drawing the Third Side of the Triangle: Reshaping EU "Technology Policy" V. State and Market in Today’s Europe: A Journey Across the EU and Nation-States Epilogue. The Time of Coincidence

Read more less

Book SynopsisThis collection breaks new ground by investigating applications of degrowth in a range of geographic, practical and theoretical contexts along the food chain. Degrowth challenges growth and advocates for everyday practices that limit socio-metabolic energy and material flows within planetary constraints. As such, the editors intend to map possibilities for food for degrowth to become established as a field of study.International contributors offer a range of examples and possibilities to develop more sustainable, localised, resilient and healthy food systems using degrowth principles of sufficiency, frugal abundance, security, autonomy and conviviality. Chapters are clustered in parts that critically examine food for degrowth in spheres of the household, collectives, networks, and narratives of broader activism and discourses. Themes include broadening and deepening concepts of care in food provisioning and social contexts; critically applying appropriate technologies;Trade Review"Food for Degrowth: Perspectives and Practices, edited by A. Nelson and F. Edwards, is an effort to understand the social and territorial expressions of the degrowth principles as applied to different areas of the food system (production, distribution, consumption). Building on fourteen diverse empirical cases, it takes the reader on a journey to discover how degrowth principles can shape alternative food practices and what are the practical limitations of implementing degrowth in our food systems toward more sustainability and justice … . Both accessible and thought-provoking, this book will be of interest to urban geographers interested in degrowth, how degrowth can shape cities and urban-rural relations, and the governance of urban transformations more broadly." – Louise Guibrunet, Geography Institute, National Autonomous University of Mexico, Mexico City, Mexico"Food for Degrowth is one more rich contribution to the Degrowth debates. As a multi-layered and multi-dimensional movement, Degrowth offers inspiring and complementary solutions from a large diversity of perspectives. After Housing for Degrowth, Food for Degrowth brings one more strong pillar showing that degrowth is not only necessary, not only possible, but mostly desirable and already happening here and around." - Vincent Liegey, Degrowth researcher and practitioner, co-author of Exploring Degrowth: A Critical Guide (2020) and coordinator of Cargonomia — a centre for research and experimentation on degrowth, a social cooperative for sustainable logistical solutions and local food distribution using cargo-bikes in Budapest"The book’s strength lies in the diversity of its contributors, with a good mix of academics, activists and grassroots workers… The book sets a tone for more works on degrowth in the future. It can be useful for students working on food sustainability cutting across Sociology, Social Anthropology, Food Studies and Environmental Studies."-- Rituparna Patgiri, excerpt from a review in Doing Sociology.orgTable of Contents1. Food for degrowth, Anitra Nelson and Ferne Edwards Part 1 Frugal abundance 2. Replacing growth with belonging economies: A neopeasant response, Patrick Jones and Meg Ulman 3. Quietly degrowing: Food self-provisioning in Central Europe, Petr Daněk and Petr Jehlička 4. Learning degrowth from women’s food knowledge and care in Kenya, Meike Brückner 5. Caring dachas: Food self-provisioning in Eastern Europe through the lens of care, Lilian Pungas Part 2 Degrowth collectives 6. Germinating degrowth? On-farm adaptation and survival in Hungarian alternative food networks, Logan Strenchock 7. Nourishing self-planned socio-ecological transformations: Glocal community supported agriculture in Veneto, Italy, Silvio Cristiano, Marco Auriemma, Paolo Cacciari, Manola Cervesato, Domenico Maffeo, Paola Malgaretto and Francesco Nordio 8. Sustaining caring livelihoods: Agroecological cooperativism in Catalonia, Patricia Homs, Gemma Flores-Pons and Adrià Martín Part 3 Degrowth networks 9. Co-creation for transformation: Food for degrowth in Budapest Food City Lab initiatives, Diana Szakál and Bálint Balázs 10. Technology for degrowth: Implementing digital platforms for community supported agriculture, Ferne Edwards and Ricard Espelt 11. Institutionalising degrowth: Exploring multi-level food governance, Ferne Edwards, Sérgio Pedro and Sara Rocha Part 4 Narratives: Degrowth contexts and futures 12. Recycling old ideals? A utopian reading of ‘circular’ food imaginaries, Deborah Lambert 13. Degrowth, decolonisation and food sovereignty in the Cree Nation of Chisasibi, Ioana Radu, Émilie Parent, Gabriel Snowboy, Bertie Wapachee and Geneviève Beaulieu 14. Food waste or surplus? Reading between the lines of discourse and action, Constanza Hepp 15. A degrowth scenario: Can permaculture feed Melbourne?, Terry Leahy 16. Future research directions: Food for degrowth, Ferne Edwards and Anitra Nelson

Read more less

Book SynopsisRevised to reflect significant advances in pharmaceutical production and regulatory expectations, Handbook of Validation in Pharmaceutical Processes, Fourth Edition examines and blueprints every step of the validation process needed to remain compliant and competitive. This book blends the use of theoretical knowledge with recent technological advancements to achieve applied practical solutions. As the industry's leading source for validation of sterile pharmaceutical processes for more than 10 years, this greatly expanded work is a comprehensive analysis of all the fundamental elements of pharmaceutical and bio-pharmaceutical production processes. Handbook of Validation in Pharmaceutical Processes, Fourth Edition is essential for all global health care manufacturers and pharmaceutical industry professionals.Key Features: Provides an in-depth discussion of recent advances in sterilization Identifies obstacles tTable of Contents1. Why Validation?, 2. Facility Design for Validation, 3. Modular Facilities – Meeting the Need for Flexibility, 4. Commissioning and Qualification, 5. Design & Quaification of Controlled Environments, 6. Validation of Pharmaceutical Water Systems, 7. Validation of Critical Utilities, 8. Calibration and Metrology, 9. Risk Management and Thermal Validation, 10. Change Control, 11. MICROBIOLOGY OF STERILIZATION PROCESSES, 12. Biological Indicators, 13. Steam Sterilization in Autoclaves, 14. Validation of Terminal Sterilization, 15. Steam Sterilization-in-Place Technology and Validation, 16. Dry Heat Sterilization, 17. Depyrogenation by Inactivation and Removal, 18. Ethylene Oxide Sterilization, 19. Validation of chlorine dioxide Sterilization, 20. Liquid Phase Sterilization, 21. Vapor Sterilization and Decontamination, 22. Validation of the Radiation Sterilization of Pharmaceuticals, 23. Validation of Sterilizing Grade Filters, 24. Disinfecting Agents: The Art of Disinfection, 25. Cleaning and Disinfecting Laminar Flow Workstations, Bio Safety Cabinets and Fume Hoods, 26. Contamination Control for Component Introduction to Classified Areas, 27. Aseptic Processing for Dosage Form Manufacture, 28. Validation of Manual Aseptic Processes, 29. Validation of Aseptic Processing for Bulk Pharmaceutical Chemicals, 30. Qualification and Validation of Advanced Aseptic Processing Technologies, 31. Total Particle Monitoring, 32. Environmental Monitoring, 33. Validation of Container Component Preparation, 34. Validation of Lyophilization, 35. Validation of Packaging Processes for Sterile Products, 36. Validation of Active Pharmaceutical Ingredients, 37. Cell Culture Process Validation including Cell Bank Qualification, 38. Validation of Recovery and Purification Processes, 39. Validation of Process Chromatography, 40. Single Use Technologies and Systems, 41. Considerations for Process Validation for Cell and Gene Therapies, 42. Validation of Solid Dosage Forms, 43. Validation of Validation of Oral / Topical Liquids & Semi-Solids, 44. Validation of Non-Sterile Packaging Operations, 45. Validation of Cleaning Processes, 46. Validation of Training, 47. Vendor Qualification and Validation, 48. Validation of Clinical Trial Manufacturing, 49. Validation of New Products, 50. Retrospective / Continuous Process Validation, 51. Validation & 6 Sigma, 52. Validation and Contract Manufacturing, 53. Computerized Systems Validation, 54. Risk Based Validation of Laboratory Information Management Systems, 55. Control Systems Validation, 56. Process Analytical Technology and Validation, 57. Validation of Analytical Procedures and Physical Methods, 58. Validation of Microbial Methods, 59. "Rapid Methods for Aseptic Processing and Their Validation", 60. Extractables and Leachables in Drug Products: An Overview, 61. Evolution and Implementation of Validation in the United States, 62. Validation in Europe - What are the Differences?, 63. Japanese Approach to Validation, 64. Organization of Validation in a MultiNational Pharmaceutical Company, 65. Validation in a Small Pharmaceutical Company, 66. Regulatory Aspects of Process Validation in the United States, 67. The Future of Validation

Read more less

Book SynopsisThe second installment of the Fisher Investments On series is a comprehensive guide to the Materials sector. Fisher Investments on Materials can benefit both new and seasoned investors, covering everything from Materials sector basics to specific industry insights to practical investing tactics, including common pitfalls to avoid.Table of ContentsForeword ix Preface xi Acknowledgments xv Part I Getting Started in Materials 1 Chapter 1 Materials Basics 3 Materials 101 4 Commodity Pricing Basics 9 The Production Process 13 Chapter 2 A Brief History of Materials 29 The Industrial Revolution 29 Structural Shifts in Metals Since the Industrial Revolution 33 Industrialization of the Emerging Markets 37 Chapter 3 Materials Sector Drivers 41 Key Drivers 42 Drivers at Work 46 Case Study: Copper 51 Part II Next Steps: Materials Details 63 Chapter 4 Materials Sector Breakdown 65 Global Industry Classification Standard (GICS) 66 Global Materials Benchmarks 67 Metals & Mining Industry 74 Chemicals 88 Construction Materials 96 Paper & Forest Products 96 Containers & Packaging 98 Chapter 5 Staying Current: Tracking Sector Fundamentals 101 What to Watch 102 Chapter 6 Case Study: The 2003 to 2007 Bull Market in Materials 117 The Backdrop 119 Demand Growth 120 Supply Constraints 130 The Growth of Mergers and Acquisitions 136 Part III Thinking Like a Portfolio Manager 139 Chapter 7 The Top-Down Method 141 Investing is a Science 141 The Top-Down Method 144 Top-Down Deconstructed 150 Managing Against a Materials Benchmark 157 Chapter 8 Security Analysis 163 Make Your Selection 164 A Five-Step Process 165 Important Questions to Ask 173 Chapter 9 Materialize Your Portfolio: Investing Strategies 181 Strategy 1: Adding Value at the Industry and Sub-industry Level 182 Strategy 2: Adding Value at the Security Level 189 Strategy 3: Adding Value in a Materials Sector Downturn 190 Strategy 4: Investing in Commodities 191 Appendix A: Materials Sector Resources 195 Appendix B: Top 10 Materials Firms by Industry 199 Notes 203 Glossary 217 About the Authors 223 Index 225

Read more less

Book SynopsisWhat makes a restaurant hot? Whose name do you need to drop to get a table? Why is one place booked solid for the next nine months while somewhere equally delicious is as empty and inhospitable as the Gobi desert?Welcome to the restaurant business, where the hours are punishing, the conditions are brutal and the Chef''s Special has been languishing at the back of the fridge for the past three days.This is an industry plagued with obsessives. Why else do some chefs drive themselves crazy in pursuit of elusive Michelin stars, when in reality all they''re doing is ''making someone else''s tea''?Nothing is left to chance: the lighting, the temperature or even the cut of the salmon fillet. There''s even a spot of psychology behind the menu. What do they want you to order? What makes them the most money? And why should you really hold back on those side dishes? In Restaurant Babylon, Imogen Edwards-Jones and her anonymous industry insider lift the lid onTrade ReviewA glorious behind-the-scenes account of London's debauched hospitality business. * Observer *Shocking and at times jaw-dropping, this is a must-read for any Babylon fans or those who like eating out. **** * Heat *Edwards-Jones gets away with stories far more bizarre than anything you would believe in a novel. Sometimes you laugh out loud at the outrageousness of it all...[her] mission is to amuse and entertain -- Marcus Berkmann * Daily Mail *What's not to like? -- David Sexton * Evening Standard *Very thoroughly researched * Observer Food Monthly, Books of the Year *

Read more less

Book SynopsisAustin, Hillman, Morris, Standard and Wolseley were a handful of the myriad marques that once constituted Britain''s indigenous motor industry. Born in 1896 into the high summer of Victorian prosperity, the native British industry survived until the collapse of The Rover Group in 2005. Jonathan Wood chronicles this industry''s 109-year life, from its production of hand-made bespoke automobiles for the fortunate few to the arrival of mass production to provide cars for the many. He looks at the factories and the people who worked in them, and examines the role played by the component manufacturers that serviced the industry. Wood also offers explanations as to why motor manufacturing followed the British motorcycle, bicycle and cotton industries into oblivion.Table of ContentsBirth of an Industry, 1896–1914 /Morris Leads the Way, 1918–29 /March of the Big Battalions, 1930–45 /Cars for World Markets, 1945–58 /Boom then Bust, 1959–74 /Epilogue: 1975 to Date /Further Reading /Places to Visit /Index

Read more less

Book SynopsisWine tourism is a rapidly growing field of industry and academic interest with changes in the consumer markets in recent years, showing an enormous interest in ''experiential'' travel. Wine Tourism Around the World is therefore an invaluable text for both students and practitioners alike and provides:* The first comprehensive introduction to wine tourism from a business, social science and policy perspective* An international perspective on wine tourism and includes detailed examples from Australia, Canada, France, Greece, Hungary, New Zealand, Portugal, South Africa, Spain, Switzerland, UK and the USA * Detailed information on the growth and development of wine tourism from both supply, demand, marketing and management perspectives Academic researchers and students in tourism and hospitality fields, as well as anyone connected with the wine industry, will find this book an essential guide to understandinTrade Review"... an invaluable text for both students and practitioners alike ... very diverse ... something for everyone with an interest in this field. The book is clearly laid out and contains an interesting mixture of illustrations, figures, tables and other statistical data."- International Journal of Hospitality ManagementTable of ContentsWine tourism: an introduction; The maturing wine tourism product: an international overview; The development of wine tourism in France; Meeting the winemaker: a case study of wine tourism product development in an emerging wine region; Wine routes in South Africa; Wine tourism and consumer behaviour; Influences on cellar door sales and determinants of wine tourism success: results from Texas wineries; Wine tourism in New Zealand; Wine tourism in the United Kingdom; Vasse Felix winery development; Wine tourism as a component of destination marketing, promotion and regional development; The development of a national wine tourism plan: wine tourism organizations and development in Australia; The Northeast wine route: wine in Ontario, Canada and New York State; Cycle trails and wine tourism in Europe; The Napa Valley, California: a model of wine region development; The future of wine tourism.

Read more less

Book SynopsisThe prevalence of naturally occurring toxins in plant and animal foods represents one of the most significant food safety issues, drawing the attention of both scientists and regulators alike. This unexplored area related to food quality is indeed a big concern for consumers, various regulatory authorities, and food industries. Apart from essential nutrients, several food crops are capable of producing a vast array of nonnutritious secondary metabolic products. These toxins produced as secondary metabolites have the potential to exhibit both beneficial and deleterious effects in both human beings and animals. Nevertheless, there has been huge progress in agricultural practices and food processing technologies, but still the number of nonnutritive substances and naturally derived toxins persist in our diet. Handbook of Plant and Animal Toxins in Food: Occurrence, Toxicity, and Prevention, focuses on various selected toxins in foods derived from plants as wTable of ContentsAn overview on Food Toxins. Phytates. Tannins. Solanine & chaconine. Oxalates. Goitrogens. Gossypol. Erucic Acid. Saponins. Cynogenic Glycoside. Phytohaemagglutinin. Enzymatic inhibitors (Protease inhibitors, Amylase inhibitors, Cholinesterase inhibitors). Glycyrrhizic Acid. BOAA: A neurotoxin. Toxic Amino Acids & Fatty Acids. Paralytic Shellfish Toxins. Maitotoxin: The Marine Toxin. Palytoxin. Gonyautoxin. Dendrotoxin. Batrachotoxin. Conotoxin. Toxins in Sea Anemone. Biogenic Amines. Emerging food toxins and contaminants.

Read more less

Book SynopsisOver three editions, this book described the contents of food raw materials and products, the chemistry/biochemistry of food components, as well as the changes occurring during post-harvest storage and processing affecting the quality of foods. The fourth edition of Chemical and Functional Properties of Food Components discusses the role of chemical compounds in the structure of raw materials and the formation of different attributes of food quality, including nutritional value, safety, and sensory properties. This new edition contains four new chapters: âœNon-Protein Nitrogenous Compoundsâ; âœProoxidants and Antioxidants in Foodâ; âœNon-Nutritive Bioactive Compounds in Food of Plant Originâ; and âœAnalytical Methods Used for Assessing the Quality of Food Products.âThese chapters have been included because new research results have brought increasing knowledge on the effect of non-protein nitrogenous compounds, especially bioactive peptides, nucleic acids, and biogenic amines on the biological properties of foods; the role of natural and added prooxidants and antioxidants in the processing and biological impact of foods; numerous beneficial and harmful effects of bioactive components of plant foods; and new systems for control of food composition and the safety of foods.Features: Stresses the effect of the chemical/biochemical reactions on the selection of optimum parameters of food processing without presenting details of the technological processes Describes naturally occurring elements and compounds as well as those generated during food handling in view of health hazards they may bring to consumers Discusses the risks and benefits of reactions occurring during food handling The knowledge of the chemistry and biochemistry of the components and their interactions presented in this book aids food scientists in making the right decisions for controlling the rate of beneficial and undesirable reactions, selecting optimal storage and processing parameters, as well as the best use of food raw materials.

Read more less

Book SynopsisAnxiety, Gut Microbiome and Nutraceuticals: Recent Trends and Clinical Evidence is focused on understanding the role of gut microbiomes on anxiety and how it can be treated using various nutraceuticals. It covers recent trends and clinical evidence in application of nutraceuticals in treating anxiety and related disorders.Table of Contents1. Nutraceuticals and its applications –recent trends and challenges. 2. Anxiety disorders: background, anatomy and pathophysiology. 3. Diagnosis and management of anxiety disorders. 4. Anxiety disorders: Symptoms and causes. 5. Pharmacology of human anxiety. 6. Gut Microbiota and Mental Health: The Gut Brain Axis. 7. Inflammation and the gut microbiome in depression and anxiety. 8. Stress, depression, diet, and the gut microbiota: human–bacteria Interactions at the core of psychoneuroimmunology and nutrition. 9. Effects of Psychological, Environmental, and Physical Stressors on the Gut Microbiota. 10. Translating evidence to real-world reproducibility and specific evidence for Nutraceuticals. 11. Nutraceuticals as modulators of gut microbiota: Role in therapy! 12. Stress disorder and gut microbiota. 13. Polyphenolic Nutraceuticals to Combat Oxidative Stress Through. 14. The Role of Functional Foods and Nutraceuticals in Gastrointestinal Health. 15. Traditional therapy of prebiotics and probiotics as treatment for anxiety and stress. 16. Oral β-Lactamase Therapies Designed for the Prevention of Antibiotic-Induced Disruption of the Gut Microbiome. 17. Recent trends in the role of the human gut microbiome in neurological function and brain disorders. 18. Synbiotic: Traditional Approach, Present Status and Future Outlook. 19. Interplay between nutraceuticals and gut microbiota some clinical evidences. 20. Manipulation of Gut Microbiome to Improve Mental Health. 21 Functional Constituents of Yacon (Smallanthus sonchifolius) for gut rejuvenation.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

Book SynopsisWhile disease is inevitable in humankind, the current century has been burdened with many chronic diseases, most of which are lifestyle mediated and, which in part can be controlled by consuming foods with specific functions. Functional Foods and Nutraceuticals for Chronic Diseases: Two Volume Set explores the role functional foods and nutraceuticals have in the development and maintenance of health, and how these can assist the body in its battle against inflammation and chronic illnesses.Volume I focuses on the clinical evidence of functional foods and nutraceuticals and chronic diseases; and Volume II discusses the molecular mechanisms, and the researches on the role of functional foods/nutraceuticals in preventing and treating chronic diseases through epigenetic modulation.Contributors hail from different geographical locations around the world and have many years of research and scholarly experience in functional foods, nutraceuticals, and biology. These volumes are a great reference for practitioners, scientists, and clinicians in the management of chronic diseases.

Read more less

Book SynopsisA hybrid methodology, Lean Six Sigma (LSS) is designed to accommodate global challenges and constraints by capitalizing on Six Sigma and Lean Thinking. LSS incorporates best practices from programs such as the International Organization for Standardization (ISO), Capability Maturity Model, and Total Quality Management.International LSS practitioners must understand the dynamics of LSS, along with its cultural aspects and regulations. Lean Six Sigma: International Standards and Global Guidelines provides this understanding.This book assumes that the overall goal of operational excellence is to ensure that organizational tasks and activities are being performed to the best of their process capabilities. It defines continuous improvement as activities that support and empower environments to make flexible decisions that lead to ongoing improvement and effectiveness. Coverage includes: New global LSS standards InternatioTable of ContentsPreface. Acknowledgments. Author. SECTION I NEW GLOBAL STANDARDS. 1 ISO 13053 International Standard for Six Sigma. 2 Lean Project Management. 3 Lean Government in the United States. SECTION II LEAN SIX SIGMA, OPERATIONAL EXCELLENCE, AND CONTINUOUS IMPROVEMENT. 4 Core Knowledge. 5 Lean Six Sigma Basics. 6 Analytical Problem-Solving Tools. 7 DMAIC Basics. 8 Define. 9 Measure. 10 Analyze. 11 Improve. 12 Control. 13 Summary of DMAIC. SECTION III INTERNATIONAL IMPLEMENTATION OF PROCESS IMPROVEMENT PROGRAMS. 14 Additional Lean Six Sigma Tools. 15 Quick Start Guide. 16 Leadership Challenge. 17 Change Management. 18 Training Modules: Using Instructional Systems Design for Lean Six Sigma Training. SECTION IV LEAN SIX SIGMA APPLICATIONS. 19 Lean Six Sigma in Healthcare: Medical Facilities. 20 Lean Six Sigma and the Medical Device Industry. 21 From Efficiency to Intelligence: Unleashing the Power of Lean Six Sigma in AI. 22 Lean Six Sigma in Innovative Thinking and Design. SECTION V INTERNATIONAL LEAN SIX SIGMA AREAS OF COMPETENCY AND RESOURCE MATERIALS. Appendix One A Brief History of Lean Six Sigma. Appendix Two Pandemic Proofing the Future with Lean Six Sigma. Appendix Three Competency Models. Reference Materials. Index.

Read more less

Book SynopsisHow to Hedge Metals is an important resource for all traders, whether new graduates or seasoned directors, and is written in simple, precise, and clear terms. It is engaging and accessible a good read rather than a reference book and provides solutions to the problems caused by metal price volatility. It walks through the entire hedging process, starting long before the first futures trade, with a discussion on risk tolerance and appetite. It explains how the world's major futures exchanges work; but more importantly, it explains how futures and options can solve physical trading problems. Written entirely from a hedger's perspective, How to Hedge Metals answers questions on issues such as Quotational Periods, option premiums, and backwardations. The aim of the book is not to promote hedging; some companies will learn how to minimise risk by changing their physical contracts, while others may conclude that the level of risk they face is acceptable. For those

Read more less

Book SynopsisWith a new subtitle to reflect its global perspective and a new author, this book continues the mission of earlier editions to describe stages of food development in detail, beginning with sources of ideas and moving through development, final screening, and introduction into the marketplace. Every chapter contains one or more case studies. New chapters address the tools available for food industry and manufacturers to select, sharpen, fine tune and support new food products launches. More attention is given to the influence of global concerns about the deteriorating environment, and here particularly, the role and responsibility of the food industry and those working on new food products.Key Featuresâ Adds the perspective from single product or product range development to the overall portfolio managementâ Explains strategies for successful management of unpredictable, uncertain, and complex conditions in new food product developmentâ Chapters contain on

Read more less

Book SynopsisThis result-oriented primer provides a practical guide to key approaches, methodologies and tools for designing, modelling and simulating chromatographic processes. With an emphasis on real-world applications, this is a must-have for practitioners and researchers working in chemical, biochemical, food and pharmaceutical engineering.Table of Contents1. An approach to modeling chromatographic processes; 2. Linear chromatography: the Russian Lego; 3. Non-linear chromatography: equilibrium theory; 4. Fluid-solid phase equilibria; 5. Mass transfer; 6. Hydrodynamics of chromatographic columns; 7. Simulating chromatographic columns; 8. Counter-current systems; 9. Presentation of chromatographic modes and their optimization; 10. Addressing a few industrial problems; 11. Conclusion.

Read more less

Book SynopsisTable of ContentsIntroduction ix Part I The Change Imperative 1 Chapter 1 Success Through Change 3 Chapter 2 What Is Bridgestone Americas? 7 Chapter 3 Recognizing a Need for Change 23 Part Ii the Six Lessons for Change 49 Chapter 4 A Prelude for Change 51 Chapter 5 Leadership: Lesson #1 55 Chapter 6 Vision: Lesson #2 95 Chapter 7 Culture: Lesson #3 107 Chapter 8 People: Lesson #4 123 Chapter 9 Alignment: Lesson #5 149 Chapter 10 Focused Execution: Lesson #6 161 Chapter 11 Restoring an Iconic Brand with the Six Lessons 171 Acknowledgments 177 About the Author 181 Index 183

Read more less

Book SynopsisCreo Parametric Modeling with Augmented Reality Tutorial-based introduction to 3D Modeling with Creo Parametric, including images to be scanned and viewed using an AR mobile app Using a tutorial approach, Creo Parametric Modeling with Augmented Reality provides an introduction to the modeling techniques and functionality of Creo Parametric, beginning with an overview of parametric design and Creo's sketching capabilities and 3D tools; proceeding through design methods and skills related to patterns, dimensions, sections, assemblies, and tolerances and GD&T; and concluding by connecting Creo's capabilities to the more specialized skills of Finite Element Analysis, mechanism animation, and sheet metal design. Each chapter includes highly visual, step-by-step examples that readers can follow to develop their modeling skills. The tutorials can be used on their own or in conjunction with an AR mobile app that allows select images to be viewed as 3D images that can be rotated, scaled, and eTable of Contents1 Introduction to Parametric Design 1 1.1 Introduction 1 1.1.1 What is Creo Parametric? 2 1.1.2 Definitions 2 1.2 Introduction to Computer-Aided Design 3 1.2.1 Design Process 3 1.2.2 Free Creo Download and Installation (Student Version) 4 1.2.3 Creo Installation 5 1.2.4 Starting Creo Parametric 7 1.2.5 Augmented Reality Companion Application and Image Targets 9 2 Introduction to Sketch 11 2.1 Introduction 11 2.1.1 Select Working Directory 12 2.1.2 Starting New Project 13 2.1.3 Start New Sketch 15 2.1.4 Add Constraints 17 2.1.5 Define and Modify Dimensions 18 2.1.6 Create Holes with Sketch 20 2.1.7 Fillet Command 22 2.1.8 Finish and Extrude the Sketch 24 2.1.9 Sketch Counterbore 25 Chapter Problems 27 3 Revolve and Sweep 31 3.1 Introduction 31 3.1.1 Start New Sketch 34 3.1.2 Select Centerline 34 3.1.3 Define and Modify Dimensions 36 3.1.4 Revolve 38 3.1.5 Start New Sketch 40 3.1.6 Create the Flap Flanges 46 3.1.7 Start New Sketch 49 3.1.8 Revolve Center Hub and Handle 51 3.1.9 Central Hub Support Modeling 52 3.1.10 Sweep Support Bar 54 3.1.11 Radial Pattern Handlebar Supports 55 Chapter Problems 57 4 3D Features/Modifiers 61 4.1 Introduction 61 Chapter Problems 82 5 Introduction to Drawing 85 5.1 Introduction 85 5.1.1 Drawing Format/Template 85 Chapter Problems 105 6 Drawing Tools 109 6.1 Introduction 109 6.1.1 Planar Section 112 6.1.2 Radial Datum Axis Circle 115 6.1.3 Part Orientation 118 6.1.4 Detail View 120 6.1.5 Offset Section Drawing 125 6.1.6 Adding Text onto the Dimensional Values 129 6.1.7 Adding an Auxiliary View 131 Chapter Problems 132 7 Assemblies 135 7.1 Introduction 135 7.1.1 Start Assembly 137 7.1.2 Start Assembly 151 7.1.3 Pattern Assembling 157 Chapter Problems 168 8 Assembly Drawings 177 8.1 Introduction to ASM Drawings 177 8.1.1 Table of Report 188 8.1.2 Create Isometric view 194 Chapter Problems 197 9 Geometric Dimensioning and Tolerancing GD&T 199 9.1 Introduction 199 9.1.1 GD&T Symbols 201 9.1.2 Dimension Tolerance 206 9.1.3 Add Datum References 209 9.1.4 Knowledge Check Activity 211 Chapter Problems 214 10 Finite Element Analysis (FEA) 217 10.1 Introduction 217 10.1.1 Simulation Lite Add-On Installation 218 10.1.2 Design Revision for FEA 230 10.1.3 Design Revision from FEA 231 10.1.4 Independent Challenge Activity 235 Chapter Problems 235 11 Mechanism Assembly 237 11.1 Introduction 237 11.1.1 Mechanism Animation 245 Chapter Problems 258 12 Sheetmetal Modeling 261 12.1 Introduction 261 12.1.1 Sheetmetal Drawing 277 Chapter Problems 281 Appendix – Augmented Reality Companion Application and Image Targets 285 Index 289

Read more less

Book SynopsisPolicy analysis is a dynamic process of discovery rather than a passive exercise of memorizing facts and conclusions. This text provides opportunities to practice the craft of policy analysis by engaging the reader in realistic case studies and problem-solving scenarios that require the selection and use of applicable investigative techniques. US Agricultural and Food Policies will assist undergraduate students to learn how policy choices impact the overall performance of agricultural and food markets. It encourages students to systematically investigate scenarios with appropriate positive and normative tools. The book emphasizes the importance of employing critical thinking skills to address the complexities associated with the design and implementation of twenty-first-century agricultural and food policies. Students are asked to suspend their personal opinions and emotions, and instead apply research methods that require the careful consideration of both facts and values. TTrade Review‘An ambitious, comprehensive examination of U.S. agricultural and food policies initiated with extensive historical backgrounds, explained with strong statistical rigor, and employing a diverse collection of economic models and graphical illustrations. The text identifies key issues facing both policy makers and subjects today through applications to appropriate scenarios with arguments based on a broad collection of classic and contemporary economic literature.’ — Dr. C. Robert Stark, Jr., Professor of Agriculture Economics and Extension Economist, School of Agriculture, University of Arkansas at Monticello, USA.Table of ContentsPrefaceChapter 1: An introduction to policy analysisChapter 2: Twenty-first-century trends, opportunities, and challenges for US agriculture and food systemsChapter 3: A policy analysis toolbox: methods to investigate agricultural and food market scenariosChapter 4: Analyzing economic consequences of farm safety net programs in the 2014 Farm BillChapter 5: The Food Safety Modernization Act (FSMA): evaluating costs and benefitsChapter 6: US agricultural and food sector connections to the global economyChapter 7: Analyzing effects of USDA nutrition programs on hunger and food security in the USChapter 8: Economic choices and outcomes for agriculture, natural resources, and the environmentChapter 9: Research, technology, and the growth of sustainable agricultural productionChapter 10: Exploring the multi-dimensional aspects of food securityChapter 11: Twenty-first-century perspectives on rural developmentChapter 12: Current developments and new dynamics influencing agricultural and food policy Chapter 13: When policies work at cross-purposes: addressing challenges and pursuing opportunities

Read more less

Book SynopsisProviding detailed analysis of the thermal comfort assessment of clothing as the basis for developing standards, this book discusses the thermal protective role of clothing as a way of modelling heat transfer from the body, general thermal regulation of humans, and the importance of globally accepted test methods and standards to improve quality. New materials and discoveries in the study of thermal comfort necessitate the need for standard improvements and update. The development of international standards and the unification of testing methods is of crucial significance to ensure cost reduction and health protection. The book promotes instruments, methods, implementation of unified specifications, and the definition of standards so that a clear quality management system can be established, for both production systems and testing methods. It discusses standards in ergonomics of the thermal environment, clothing thermal characteristics, and subjective assessment of thermal coTrade Review"This book shows the importance of modeling heat losses from the human body as an important factor in optimizing the comfort of clothing, as well as the need for assessment of thermal comfort and standardization of the related testing methods…Except for chapters 2 and 3, where some quantitative analysis is presented, the treatment here is straightforward and descriptive. The book is just right for interested general readers with some knowledge of physics."--S. D. El Wakil, emeritus, University of Massachusetts Dartmouth, CHOICE Table of Contents1. Introduction. 2. Behind the Scenes: Thermal Regulation in Humans. 3. Modelling the Heat Losses from the Human Body. 4. The Importance of Globally Accepted Test Methods and Standards. 5. The Standardization on Thermal Comfort. 6. Who Creates Standards? 7. The Standardisation on Thermal Comfort. 8. The Distribution of Standards on Thermal Comfort. 9. The Overview of the Most Significant Standards on Thermal Comfort. 10. Conclusion. 11. References. 12. Dictionary: Basic Terms and Units.

Read more less

Book SynopsisTransform your ideas into commercial biomedical products, and start your own business, with this updated second edition. Containing over 25% brand new material, this book combines real-world case studies with industry tips to walk you step-by-step through the process of commercialization.Trade Review'The first edition of the book was one of the first textbooks related to commercialization of biomedical products and it also provided the most comprehensive coverage related to this topic at the time. This second edition is a timely update of this work and also includes content related to starting new ventures.' Juergen Hahn, Professor and Department Head, Department of Biomedical Engineering, Department of Chemical & Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute and Leader of the Biomedical Engineering Society's Council of Chairs 2023'This long-awaited 2nd edition is a must-read for anyone wishing to successfully lead, manage and support the highly regulated development process for biomedical innovation. The book illustrates in a systematic and structured way the technical and business aspects required for the commercialization of new biomedical technologies. Read this book - and learn from one of the best!' Heidrun Flaadt Cervini, Director and Founder of Center of Advanced Studies on Entrepreneurship in BioMedicine (CASE BioMed), Università della Svizzera italiana, Lugano, Switzerland'Bringing early-stage life science innovations from the lab to the market, and into the hands of patients, is both critically important and fraught with risk. This book is a comprehensive resource that should help many of these innovations cross the so-called 'valley of death' more quickly and effectively.' Orin Herskowitz, Senior Vice President for Applied Innovation and Industry Partnerships for Columbia University, Executive Director of Columbia Technology Ventures (CTV) and Adjunct Professor at Columbia's Business and Engineering Schools'It was thrilling to see that a book of this nature and sophistication exists. I wish I had been able to read it before I transitioned from academia to the private sector. It should be required reading for anyone thinking of starting a biotechnology company, and it is a useful reference for many of the subtleties and complexities of this industry that most participants in the past have had to learn from the school of hard knocks.' Charles Cantor, Professor Emeritus, University of BostonTable of Contents1. The biomedical device and drug industry and their markets learning points; 2. Markets of interest and market research steps learning points; 3. Starting up your company; 4. Intellectual property and licensing; 5. New product development (NPD); 6. The regulated market: gateway through the FDA learning points; 7. Manufacturing; 8. Reimbursement, marketing, sales, and product liability learning points.

Read more less

Book Synopsis

Read more less

Book SynopsisFirst flown in 1969, Concorde was the first supersonic aircraft to go into commercial service in 1976 and made her final flight in 2003. She was operated primarily by British Airways and Air France. British Airways'' Concordes made just under 50,000 flights and flew more than 2.5 million passengers supersonically. A typical London to New York crossing would take a little less than three and a half hours compared to around eight hours for a subsonic flight. In November 1986 a Concorde flew around the world, covering 28,238 miles in 29 hours, 59 minutes.Today, Concordes can be viewed at museums across US, including in New York, Seattle, and Washington D.C. However, there have been recent reports suggest that a Concorde may start operating commercially again. Through a series of key documents the book tells the story of how the aircraft was designed and developed, as well as ground-breaking moments in her commercial history.

Read more less

Book SynopsisFrom large-scale cattle farming to water pollution, meat— more than any other food—has had an enormous impact on our environment. Historically, Americans have been among the most avid meat-eaters in the world, but long before that meat was not even considered a key ingredient in most civilizations’ diets. Labor historian Wilson Warren, who has studied the meat industry for more than a decade, provides this global history of meat to help us understand how it entered the daily diet, and at what costs and benefits to society.Spanning from the nineteenth century to current and future trends, Warren walks us through the economic theory of food, the discovery of protein, the Japanese eugenics debate around meat, and the environmental impact of livestock, among other topics. Through his comprehensive, multifaceted research, he provides readers with the political, economic, social, and cultural factors behind meat consumption over the last two centuries. With a special focus on East Asia, Meat Makes People Powerful reveals how national governments regulated and oversaw meat production, helping transform virtually vegetarian cultures into major meat consumers at record speed.As more and more Americans pay attention to the sources of the meat they consume, Warren’s compelling study will help them not only better understand the industry, but also make more informed personal choices. Providing an international perspective that will appeal to scholars and nutritionists alike, this timely examination will forever change the way you see the food on your plate.

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book SynopsisDemocratizing Technology provides a much-needed fresh perspective on the regulation of chemicals, and an important contribution to green thinking about technology.Caroline Lucas, Green Party MEP. This book is an excellent critique of the current risk-based approach to technology. By exploring the philosophical underpinnings and the practical applications of current policy on science and technology, Chapman exposes the serious flaws in allowing economic considerations to dominate the agenda in this area. Her proposals for reform are expertly constructed and deserve urgent and serious consideration by policy-makers.Dr Stuart Parkinson, Executive Director, Scientists for Global Responsibility. In this important book Anne Chapman argues that decisions about technology should answer a republican question: what kind of public world should we create through technology? Democratizing Technology deserves to be read widely. John ONeill, Professor of Political Economy, University of Manchester, UK A welcome addition to the new, more empirical and applied literature in philosophy of technology. This book will be essential reading for a variety of scholars and for the general reader intent on understanding, and criticizing, our chemically made world.Andrew Light, Interim Director, Program on the Environment, University of Washington, US What is technology? How do humans use it to build and modify the world? What are the relationships between technology, science, economics and democratic governance? What, if any, are our ethical and political responsibilities and choices in how we develop, deploy and control technology in democratic states? Democratizing Technology sets out to answer these questions. Focusing on the most widespread and pervasive technology - chemicals - this groundbreaking volume peels apart the critical technology debate to look at the relationship between humans, technology and the biological world. Attention is given to the immensely important new regulations, REACH (Registration, Evaluation, Authorization and restriction of Chemicals), the EUs largest ever legal framework, discussing the problems that are likely to occur in REACHs reliance on risk assessment methods and suggesting an alternative way forward for the regulation of chemicals. Providing much-needed clarity and insight into the heart of key debates in science and technology, risk analysis and mitigation, and domestic and international law, this volume arrives as a breath of fresh air.Trade Review'Democratizing Technology is an interesting book with contorversial opinions and proposals. [...] The book is a good candidate for the start of many interesting discussions in and out the classroom. Recommended.' R.E. Buntrock, formerly, University of Maine, USA 'Where the book excels is the thoughtful exploration of questions of profound relevance to public health, such as divergence between our understanding, our behaviours and public policies with respect to risk and responsibility. The analysis provides innovative insights for behaviouralists, policy development in both theoretical and practical spheres, ethicists, political analysts, environmental health scholars and all who encounter technology, and wonder about how we personally and collectively respond to technology in our midst.' Australian and New Zealand Journal of Public Health 'An interesting book with controversial opinions and proposals... Recommended' ChoiceTable of ContentsPreface * Acknowledgements * Introduction * What is Technology? * Technology as World-Building * Technology, Science and the Economy * The Regulation of Chemicals * Risk * Assessing Risks from Chemicals * The Ethical and Political Framework of Regulation * Responsibility * Making Decisions about Technology * Index

Read more less

Book SynopsisThe straight eight engine, also known as the inline eight engine, was the driving force behind some of the most fascinating luxury vehicles of the first half of the twentieth century. From its introduction in the 1920s through its demise in the 1950s, the straight eight graced a number of upmarket vehicles from makers like Pontiac, Packard, and Daimler, and even appeared under the hood of the hyper-exclusive Rolls-Royce Phantom IV, of which only eighteen models were produced. Although it was eventually replaced by the V8 engine, the straight eight engine can be found in some of the most valuable and sought-after vehicles of all time. Keith Ray's The Straight Eight Engine is the first volume to be published about this extraordinary mechanism. Featuring four hundred images, the book is a lush tribute to an automotive component likely to never be equaled for smoothness and refinement.Table of ContentsPrefaceIntroductionWhy the Straight Eight?Technical Problems with Straight Eight Engine DesignThe Straight Eight: A Kiss Of Death?The Birth of the Straight Eight AutomobileAn Overview of the ManufacturersAlfa RomeoAlvisAmilcarArrol-AsterAuburnBalboaBallotBentleyBeverley-BarnesBrennaborBrough SuperiorBugattiBuickBurneyChandlerChenard et WalckerChryslerCordDaimlerDe Dion BoutonDe SotoDelageDianaDiattoDodgeDuesenbergDupontElcarEssexFerrari (Auto Avio 815)FiatFNFrontenacGardnerGraf & StiftGraham-PaigeHamptonHartzHillmanHorchHudsonHupmobileIsotta FraschiniJensenJordanKenworthyKisselLa SalleLanchesterLeylandLocomobileMarendazMarmonMaseratiMathisMcFarlanMercedes BenzMillerMinervaMoonNashOldsmobileOpelPackardPanhard LevassorPeerlessPierce ArrowPontiacRailtonRallyRenaultReoRickenbackerRoamerRohrRolland PilainRolls-RoyceRuxtonSalmsonSkodaStearns-KnightStoewerStudebakerStutzSunbeamTriumphWeigelWindsorWolseleyZis & ZilStraight Eights in the Air and on the WaterStraight Eight AdvertisingIndex

Read more less

Book SynopsisThe concept of mobile ice cream factories, having been brought to Britain by the ice cream industry, but by body-builders, Smiths Delivery Vehicles of Gateshead, is one of the most intriguing stories in the British motor industry. This book charts the roller coaster history of the Mister Softee brand through successive owners.

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book SynopsisThis practical guide for advanced students and decision-makers in the pharma and biotech industry presents key success factors in R&D along with value creators in pharmaceutical innovation. A team of editors and authors with extensive experience in academia and industry and at some of the most prestigious business schools in Europe discusses in detail the innovation process in pharma as well as common and new research and innovation strategies. In doing so, they cover collaboration and partnerships, open innovation, biopharmaceuticals, translational medicine, good manufacturing practice, regulatory affairs, and portfolio management. Each chapter covers controversial aspects of recent developments in the pharmaceutical industry, with the aim of stimulating productive debates on the most effective and efficient innovation processes. A must-have for young professionals and MBA students preparing to enter R&D in pharma or biotech as well as for students on a combined BA/biomedical and natural sciences program.Table of ContentsList of Contributors XVII Foreword XXI 1 Introduction to the Book 1Alexander Schuhmacher, Oliver Gassmann, and Markus Hinder Reference 8 2 Global Epidemiological Developments 11Stephan Luther and Peter Schmitz 2.1 Introduction 11 2.2 Model of Epidemiological Transition 12 2.3 Global Burden of Diseases 15 2.3.1 Trends in the Distribution of Disease Burden 16 2.4 Infectious Diseases 20 2.4.1 (Re-)emerging Infectious Diseases 23 2.4.2 Neglected Tropical Diseases 26 2.5 Noncommunicable Diseases 29 2.6 Antimicrobial Resistance 32 2.7 Dynamics 35 References 38 3 The Value of Pharmaceutical Innovation: Concepts and Assessment 45Sam Salek and Paul Kamudoni 3.1 Introduction 45 3.2 Concepts and Definitions of Value 46 3.3 Stakeholder’s Perspectives on Value 47 3.3.1 Drug Regulatory Agencies 47 3.3.2 Health Technology Assessment 47 3.3.3 Patients 49 3.3.4 Prescribers/Clinicians 49 3.4 Recent Developments Influencing the Definition and Assessment of Value 50 3.5 Recommendations: Implications for R&D 51 3.6 Discussion 52 3.7 Conclusion 56 References 57 4 A Review of the Pharmaceutical R&D Efficiency: Costs, Timelines, and Probabilities 61Alexander Schuhmacher, Oliver Gassmann, and Markus Hinder 4.1 Introduction 61 4.2 The Historical Perspective 62 4.3 The R&D Phase Model 63 4.4 The Low R&D Success Rates 63 4.5 The Long R&D Time Intervals 67 4.6 The High Cost of Pharmaceutical R&D 71 4.7 The Reduced R&D Efficiency 73 4.8 Can an Increase in R&D Value Compensate the Reduced R&D Efficiency? 76 References 78 5 Financing Pharmaceutical Innovation 81Sviataslau Sivagrakau 5.1 Introduction 81 5.2 Measuring Innovation: Categories of New Drugs 84 5.3 Productivity of Pharmaceutical Industry throughout Time 86 5.4 Measuring the Cost of Developing New Medicines 87 5.5 Funding Drug Development: a Global Endeavor 91 5.6 Public and Private Funds: Complementary Finance for Drug Development 95 5.7 How Commercial Drug Development Projects Are Financed Today: Big Firms, Small Firms, andTheir Cooperation 97 5.8 Public Health Economics and Financing Pharmaceutical Innovation 99 5.9 Conclusion 101 Acknowledgment 102 References 102 6 Challenges and Options for Drug Discovery 107Werner Kramer 6.1 Introduction 107 6.2 Paradigm Shifts of R&D Organizations 108 6.3 Productivity of Drug Discovery 109 6.4 IsThere an Innovation Gap in Biomedical Research? 111 6.4.1 To Go for First in Class or Best in Class 112 6.4.2 HowWe Define Medical Innovation? 112 6.5 Why Did Drug Candidates Fail? 113 6.5.1 Why Is the Dropout Rate So High in Early Clinical Development? 115 6.5.1.1 Drug Behavior In Vivo: Role of Transport Proteins 115 6.5.1.2 Hypes and Lack of Scientific Thoroughness 116 6.6 Implications from the "Lessons Learnt" for Future Drug Discovery Research 123 6.6.1 Organization of Drug Discovery and Development 123 6.6.2 Elucidation of the Physiological Validity of a Target for the Human Disease 125 6.6.2.1 Extensive Inquiry of (All) Published Data of a Target or Pathway 125 6.6.2.2 Integrative Knowledge Management 127 6.6.2.3 Demonstration of the Involvement of a Target in Human Disease 128 6.6.2.4 A Stringent and Comprehensive Test Sequence 132 6.6.2.5 Translational Clinical Trials 135 Acknowledgment 136 References 136 7 Translational Medicine: Enabling the Proof of Concepts 141Gezim Lahu and John Darbyshire 7.1 Introduction 141 7.2 Translational Medicine and Its Role/Value in Early Development 143 7.3 Knowledge Generation 144 7.4 Types of Data, Experiments, and Tools Needed to Move from Basic Research to Early Clinical Development 144 7.4.1 Dose Selection 145 7.4.2 Animal Models 146 7.4.3 Fraction of NOAEL and Efficacious Dose 149 7.4.4 Allometric Scaling and PBPK 150 7.4.5 Physiologically Based Pharmacokinetic Models PBPK 151 7.4.6 Pharmacokinetic and Pharmacodynamic Modeling 151 7.5 FIM (Dose Escalation and MTD) 153 7.6 Proof of Concept (PoC) 154 Summary 156 References 157 8 Preclinical Safety and Risk Assessment 161Paul Germann and Rob Caldwell 8.1 Introduction 161 8.2 Test Systems 161 8.2.1 In Silico Analysis 161 8.2.2 In Vitro Experiments 162 8.3 Case Study: hERG Assay 163 8.3.1 In Vivo Experiments 164 8.4 The Preclinical "Package" during the Development of an NME 165 8.5 Factors Influencing the Preclinical Data Set 166 8.5.1 Timing and Costs 167 8.5.2 Intended Clinical Application Route 167 8.5.3 Treatment Duration and Treatment Frequency 167 8.5.4 Clinical Indication 167 8.5.5 Ongoing Changes of the Regulatory Landscape 168 8.5.6 New Drug Formats 168 8.6 Translation into Humans:The "TherapeuticWindow" 169 8.7 Influence of Intended Therapeutic Use on the Risk Assessment (RA) 169 8.8 Deep Dive Case Study: Safety Assessment of Biological Drug Formats 170 8.9 NBE Case Study 1 175 8.10 NBE Case Study 2 175 8.11 Carcinogenicity Risk Assessment for Marketed Drugs 176 8.12 Treatment Duration 178 8.13 Conclusion – the "Art" of Preclinical Safety: Summarizing the Concept of Hazard Identification and Description, Risk Assessment, and Risk Management 179 Acknowledgment 179 Disclosures 180 References 180 9 Developing Commercial Solutions for Therapeutic Proteins 183Galina Hesse 9.1 Introduction 183 9.2 Developing Commercial Solutions for Therapeutic Proteins 184 9.2.1 Defining a Target Product Profile 184 9.2.2 Developing Formulations for Therapeutic Proteins 186 9.2.3 Testing Formulations for Therapeutic Proteins 188 9.2.4 Development of Primary Containers 188 9.2.5 Development of Application Systems 190 9.3 Quality by Design 192 9.4 Examples for Innovations in Manufacture of Sterile Pharmaceutical Products 194 9.5 Summary 197 List of FDA/ICH Guidances Referenced 198 Disclaimer 199 References 199 10 The Evolution of Clinical Development: From Technical Success to Clinical Value Creation 203Markus Hinder and Alexander Schuhmacher 10.1 Introduction 203 10.2 CD: Changes and Challenges 204 10.2.1 Clinical Endpoints: From Symptom-Oriented Endpoints to Hard and Predefined Endpoints 204 10.2.2 Determination and Quantification of Risks 205 10.2.3 Assessment of Medical Progress in Context of Available Therapeutic Options 206 10.2.3.1 EbM 206 10.2.3.2 Health Economics, Pharmacoeconomics, and the Fourth Hurdle 207 10.2.3.3 Results of These Changes and Challenges 208 10.3 Technical Success and Clinical Value Creation in CD in the Future 208 10.3.1 Established and Novel Approaches to Determine the Dose–Exposure–Response Relationship 210 10.3.2 Comparators 212 10.3.3 Patient Stratification to Increase Treatment Response and Benefit and Reduce Risk 212 10.3.4 New Operational Tools to Succeed in Trials with Increased Complexity, Special Populations, or Large Size 213 10.3.5 Collaboration and Outsourcing as Tools toWork in Networks 214 10.3.6 Collaboration across Sectors and Industries to Boost the NextWave of Innovation 215 Disclaimer 218 References 218 11 Translational Development 225Nigel McCracken 11.1 Introduction 225 11.1.1 Legacy 226 11.2 Translational Development 227 11.2.1 TP 228 11.2.2 Translational Toolkit 229 11.3 Dose Optimization 230 11.3.1 Physicochemical Properties 231 11.3.2 Target Affinity and Selectivity 231 11.3.3 Clearance 231 11.3.4 Prediction of Human Dose 232 11.4 Pharmacogenomics 233 11.4.1 Patient Segmentation 233 11.4.2 Disease Segmentation 234 11.4.3 Utility 237 11.5 Biomarker Development 238 11.5.1 Biomarker Activities 239 11.5.2 Assessing the Opportunity 239 11.6 Systems Pharmacology 240 11.7 Rational Drug Development 241 11.8 Concluding Remarks 242 References 242 12 Forty Years of Innovation in Biopharmaceuticals – Will the Next 40 Years Be as Revolutionary? 245Mathias Schmidt, Sanjay Patel, Petter Veiby, Qiang Liu, and Michael Buckley 12.1 Introduction 245 12.1.1 The Value Proposition of Biologics 246 12.1.1.1 The Patient Perspective 246 12.1.1.2 The Pharmaceutical Industry’s Perspective 248 12.1.2 Biosimilars: A Blessing or aThreat to Innovation? 250 12.1.3 Further Innovation in Biologics – Incremental or Revolutionary? 252 12.2 The Evolution of Biologics Manufacturing 252 12.2.1 Introduction 252 12.2.2 CHO Cells: The Industry Workhorse 253 12.2.3 Protein Production Strategies 253 12.2.4 The Impact of Increasing Titers on Manufacturing Facilities 255 12.2.5 Protein Purification Platforms 256 12.2.6 Conclusion: WhatWill the Next 40 Years of Innovation Bring? 258 12.3 The Evolution of Alternative Scaffolds 259 12.3.1 Novel Small Protein Scaffolds 260 12.3.2 Single-Chain Fragment Variables and Diabodies 260 12.3.3 Single-Domain Antibodies 261 12.3.4 Nonantibody Scaffolds 261 12.3.5 Bispecific Single-Chain Fragment Variables and Diabodies 263 12.3.6 Other Bispecific Antibody Formats 264 12.4 Antibody-Drug Conjugates 265 12.5 The Next Wave of Biologics 270 12.5.1 Orally Available Biologics 271 12.5.2 Biologics That Enter the Cytoplasm 271 12.5.3 Biologics That Pass the Blood–Brain Barrier 272 12.5.4 Translational Medicine as Driver of Innovation 272 Disclaimer 273 References 273 13 Vaccines: Where Inertia, Innovation, and Revolution Create Value, Simultaneously and Quietly 277Pierre A. Morgon and Hannah Nawi 13.1 Introduction 277 13.2 TheWorld of Vaccines 278 13.2.1 What Are Vaccines? 278 13.2.2 Current Vaccines Are Mainly Prophylactic: Curative Vaccines Are Emerging 278 13.2.3 Drivers to Immunize: Individual and Collective 280 13.2.4 The Pivotal Role of Recommendations 280 13.3 The Vaccine Market: Substantial, Fast Growing, with Intense and Concentrated Competition 281 13.4 The Vaccine Industry: Domination of the Heavyweights, for Now… 282 13.4.1 Barriers to Entry: From R&D Risk to Capital Intensiveness 290 13.4.2 Five Forces Analysis: Competitive Intensiveness and Downstream Hurdles 291 13.4.2.1 Acceptability 291 13.4.2.2 Accessibility 292 13.4.2.3 Availability 293 13.4.2.4 Affordability 293 13.5 New Vaccine Developments: Strategic Trends and Why Innovation Is Needed All along the Value Chain 295 13.5.1 Where Is Innovation Needed? R&D 296 13.5.2 Where Is Innovation Needed? Manufacturing and Product Improvement 301 13.5.3 Where Is Innovation Needed? Acceptability 301 13.5.4 Where Is Innovation Needed? Accessibility, Both as a Function of Supply (Availability) and Logistics 302 13.5.5 Affordability and Sustainability 303 13.6 WhereWill Innovation Come from? Strategy and Players 304 13.6.1 Take-Home Messages 305 References 306 14 The Patient-Centric Pharma Company: Evolution, Reboot, or Revolution? 309Pierre A. Morgon 14.1 Introduction 309 14.2 Health, Always… 310 14.3 The Mission of the Healthcare Industry 310 14.4 Megatrends Affecting the Strategic Scorecard of the Healthcare Industry 312 14.5 Focus on the Societal Trends and Their Consequences for the Management of Healthcare Innovation 314 14.6 The DNA of the Healthcare Industry: R&D and the Management of Innovation 316 14.7 Societal Expectations for Personalized Medicine 318 14.8 New Players Contributing to Information Management to Substantiate Value Propositions for NovelTherapies 319 14.9 The Role of the Key Stakeholders in Shaping a New Regulatory Framework 323 14.10 The Consequences for the Healthcare Industry in Terms of Governance and Capabilities 325 14.11 The Sustainable Path Forward for the Healthcare Industry 329 14.11.1 Take-Home Messages 331 References 332 15 The Pharmaceutical Industry is Opening Its R&D Boundaries 335Alexander Schuhmacher and Ulrich A. K. Betz 15.1 Introduction 335 15.2 Open Innovation versus Closed Innovation 336 15.3 Business Models in an Open Innovation Framework 341 15.4 Open Innovation Processes 342 15.5 Capabilities and Attitudes Enabling Open Innovation 344 15.6 Open Innovation in the Pharmaceutical Industry 345 15.6.1 The More Traditional Elements of Open Innovation 345 15.6.1.1 Target Scouting 345 15.6.1.2 Research Collaborations 346 15.6.1.3 Drug Licensing 346 15.6.1.4 Outsourcing 348 15.6.1.5 Joint Ventures 349 15.6.2 The Newer Concepts of Open Innovation 349 15.6.2.1 New Frontier Science 350 15.6.2.2 Drug Discovery Alliances 350 15.6.2.3 Private–Public Partnerships 351 15.6.2.4 Innovation Incubator 351 15.6.2.5 Virtual R&D 352 15.6.2.6 Crowdsourcing 353 15.6.2.7 Open Source Innovation 355 15.6.2.8 Innovation Camps 355 15.6.2.9 Fluctuating Open Teams 356 15.7 New Business Models in View of the Potential of Open Innovation 356 15.7.1 General Trends in the Pharmaceutical Industry 356 15.8 Outlook 358 References 359 16 Out-Licensing in Pharmaceutical Research and Development 363Oliver Gassmann, Carol A. Krech, Martin A. Bader, and Gerrit Reepmeyer 16.1 Introduction 363 16.2 Performance-Based R&D Collaborations on the Rise 364 16.3 The Impact of Collaborations on the Value Chain 365 16.4 Generating Value from Pipeline Assets by Out-Licensing 367 16.5 Pharmaceutical Companies’ Resistance toward Out-Licensing 372 16.6 Managing Out-Licensing at Novartis: A Case Study 372 16.6.1 Out-Licensing as a 10-Step Process 373 16.6.2 Out-Licensing Contract Design 375 16.6.3 Structure of the Out-Licensing Collaboration with Speedel 375 16.7 Future Directions and Trends 377 References 378 17 Trends and Innovations in Pharmaceutical R&D Outsourcing 383Antal K. Hajos 17.1 Introduction 383 17.2 Drivers to the Use of Outsourcing 383 17.2.1 Overview on the CRO Market 383 17.2.2 Core versus Noncore Activities 387 17.3 Genesis of Outsourcing in the Twentieth Century: From Commodity to Contribution 388 17.3.1 Outsourcing Portfolio and the Move to Full-Service Provision 388 17.3.2 Globalization and the Emerging Market Hype 389 17.3.3 Procurement Takes over the Outsourcing Function 391 17.4 Current and Future Trends in Outsourcing: From Contribution to Innovation 392 17.4.1 How Has Outsourcing Itself Innovated and What Are the Future Trends? 392 17.4.2 How Does andWill Outsourcing Contribute to Innovation? 394 17.5 Discussion and Conclusion 395 References 398 18 New Innovation Models in Pharmaceutical R&D 401Alexander Schuhmacher, Oliver Gassmann, and Markus Hinder 18.1 Introduction 401 18.2 Some AttemptsThatWere Recommended in the Past 402 18.3 The Increasing Pipeline Size 403 18.4 The Reduction of R&D Investments 404 18.5 The Opening of the R&D Processes 407 18.6 The Challenge with the Return on Investment 411 18.7 Changing the R&D Processes Is Not Enough 412 18.8 What Is the Best R&D Model? 413 References 414 19 The Influence of Leadership Paradigms and Styles on Pharmaceutical Innovation 416Aubyn Howard 19.1 Introduction 417 19.2 What Is Your Concept or Model of Good Leadership? 419 19.3 Approaches to Leadership Modeling and Profiling 420 19.3.1 Personality Types 421 19.3.2 Behavioral Preferences 421 19.3.3 Developmental Stages 421 19.3.4 Competency Frameworks 421 19.4 The Developmental Approach to Leadership Paradigms and Styles 422 19.5 Inner and Outer Leadership 424 19.6 Dynamics of How Leadership Paradigms Evolve 425 19.6.1 Magic–Animistic 426 19.6.2 Impulsive–Egocentric 427 19.6.3 Conformist–Absolutist 428 19.6.4 Achievement–Multiplistic 429 19.6.5 Pluralistic–Relativistic 430 19.6.6 Evolutionary–Systemic 432 19.7 Leadership at Different Levels within Pharma 433 19.8 Optimizing Innovation in Different Organizational Models and Cultures 437 19.9 How DoWe Support the Development of Evolutionary Leaders? 439 19.10 What Does It Mean to Operate from the Evolutionary Paradigm? 440 19.11 Leadership and Personal Mastery 441 19.12 Building an Evolutionary Bridge to Release Innovation 442 19.13 Conclusions 445 References 446 20 The Role of Modern Portfolio Management in Pharma Innovation 449Joachim M. Greuel and Axel Wiest 20.1 Introduction 449 20.2 Challenges in R&D and the Origin of Pharmaceutical Portfolio Management 450 20.3 Goals and Metrics of Portfolio Management 451 20.4 Portfolio Management as Enabler of Innovation 456 20.5 Modern Portfolio Management Integrates In-House R&D, Business Development, and M&A 457 References 458 21 Patent Management Throughout the Innovation Life Cycle 461Martin A. Bader and Oliver Gassmann 21.1 Introduction 461 21.2 The Changing Role of Patents: From Legal to Strategic 462 21.3 The Patent Life Cycle Management Model 467 21.3.1 Exploration 468 21.3.2 Generation 469 21.3.3 Protection 469 21.3.4 Optimization 470 21.3.5 Decline 470 21.4 Example: Managing IP Rights at Bayer 471 21.5 Concluding Remarks 472 References 473 Index 475

Read more less

Book SynopsisAi Hisano reveals how the food industry capitalized on color, fashioning a visual vocabulary that shapes what we think of the food we eat. Our perceptions of what food should look like have changed dramatically as scientists, farmers, food processors, regulators, and marketers established a new, and highly engineered, version of the “natural.”Trade ReviewRichly textured and full of colorful characters, Ai Hisano’s Visualizing Taste shows us that what many consider ‘natural’ about food is in fact historically and culturally constructed. This book highlights how central the history of the senses is to the development of capitalism and modern consumption. Original, fascinating, and eye-opening. -- Daniel Horowitz, author of Happier? The History of a Cultural Movement That Aspired to Transform AmericaAn intriguing analysis that establishes food color as a critical example of how twentieth-century business strategies deployed the human senses. Visualizing Taste makes us think about what color means, to producers and to consumers. -- Susan Strasser, author of Satisfaction Guaranteed: The Making of the American Mass MarketSeeing is believing, right? Not so fast. In this nuanced and highly original history of the ‘capitalism of the senses,’ Ai Hisano shows how the American food industry taught consumers to associate particular food colors with freshness, authenticity, and safety. In colonizing perception to suit business needs, food marketers radically changed the way we think about nature, health, beauty, and truth itself. -- Warren Belasco, author of Appetite for Change: How the Counterculture Took On the Food IndustryVisualizing Taste makes a major contribution to business history and the history of the senses by investigating the multiple factors, including government regulation, that have shaped the visual presentation of today’s comestibles. Through Ai Hisano’s critical interrogation of the color code, this book will refresh your palate. -- David Howes, Concordia UniversityHisano’s book provides a compelling historical perspective on contemporary debates on sensory marketing and branding. -- John Quelch, Miami Business SchoolHisano examines how the appearance of everyday foods has changed from 1870 to 1970 in the United States…Natural dyes were common before synthetic alternatives offered an extensive spectrum of artificial colors. This fundamentally changed not only the color of processed foods like Jell-O and meats but also of fresh foods like fruits and vegetables—all at the behest of corporate interests. The author reveals the irony that growers, producers, and retailers redefined these ‘artificial’ colors as ‘fresh’ and ‘natural.’ -- Barkha Kagliwal * Technology and Culture *

Read more less

Book SynopsisThe global electronics industry is one of the most innovation-driven and technology-intensive sectors in the contemporary world economy. From semiconductors to end products, complex transnational production and value-generating activities have integrated diverse macro-regions and national economies worldwide into the "interconnected worlds" of global electronics. This book argues that the current era of interconnected worlds started in the early 1990s when electronics production moved from systems dominated by lead firms in the United States, Western Europe, and Japan towards increasingly globalized and cross-macro-regional electronics manufacturing centered in East Asia. By the 2010s, this co-evolution of production network complexity transformed global electronics, through which lead firms from South Korea, Taiwan, and China integrated East Asia into the interconnected worlds of electronics production across the globe. Drawing on literature on the electronics industry, new empirical material comprising custom datasets, and extensive personal interviews, this book examines through a "network" approach the co-evolution of globalized electronics production centered in East Asia across different national economies and sub-national regions. With comprehensive analysis up to 2021, Yeung analyzes the geographical configurations ("where"), organizational strategies ("how"), and causal drivers ("why") of global production networks, setting a definitive benchmark into the dynamic transformations in global electronics and other globalized industries. The book will serve as a crucial resource for academic and policy research, offering a conceptual, empirically driven grounding in the theory of these networks that has become highly influential across the social sciences.Trade Review"Henry Wai-chung Yeung provides a comprehensive and fascinating analysis of the decisive role of global production networks in driving the shift of global electronics industry to East Asia in the early 21st century. The book features rich and detailed firm level data, an excellent resource for both teaching and research. It is a must-read for anyone seeking to understand the dominance of East Asia in the industry."—Yuqing Xing, Professor of Economics, National Graduate Institute for Policy Studies"Henry Wai-chung Yeung's highly original and insightful book provides us understanding of a deeper and wider form of global production integration than that of global value chains. These are interconnected worlds of global production. The interdependencies that he captures shed light on new possibilities for global development, but also deep challenges and risks for global development policy, as well as global business."—Michael Storper, Professor of Economic Geography, London School of Economics; Distinguished Professor of Regional and International Development, UCLA"From startling revelations about the centrality of semiconductors in modern manufacturing to current debates on deglobalization, decoupling and the reshoring of global supply chains, the electronics industry has moved to center stage in public awareness. Interconnected Worlds could not be more timely in unpacking the regional roots of global electronics and bridging academic, firm strategy and policy domains."—Gary Gereffi, Emeritus Professor and Director of the Global Value Chains Center at Duke University, Durham, NC"This book is Yeung's remarkable update on his long-time study on electronic industry in Asia and the globe, comprising semi-conductors, cell phones, PCs and displays. It reflects his intellectual journey from his early focus on inter-national political economy to a new network approach on inter-firm and intra-firm production activities across national boundaries. It is timely and extremely helpful to understand the nature of the disruptions in global value chains since the US-China trade conflicts and the Covid-19, and also to derive effective responses to them."—Keun Lee, Distinguished Professor, Seoul National University; winner of the 2014 Schumpeter Prize"Yeung [has] made a significant contribution to our understanding of how the globe's most important technology-based industries are evolving."—Robert Huggins and Andrew Johnston, Eurasian Geography and Economics"[Interconnected Worlds] offers an empirical, grounded study that will inform research on the reconfiguration of global electronics production networks in the decades to follow... No doubt it will represent a 'benchmark for assessing changes in the early 2020s and beyond'."—Chun Yang, Regional Studies"Interconnected Worlds makes an excellent contribution to explaining the evolution of electronics GPNs by the integration of companies in East Asian [sic] or, alternatively, by tracking the shift of electornics GPNs to East Asia. It is a thorough and exhaustive piece of work and easily the most complete analysis of the electronics sector in East Asia and its integration with electronics GPNs."—Seamus Grimes, Economic GeographyTable of Contents1. Worlds of Electronics: From National Innovations to Global Production 2. Changing Fortunes in Global Electronics: A Brief History 3. Global Production Networks: A Theory of Interconnected Worlds 4. Geographical Configurations of Global Electronics Centered in East Asia 5. Firm Strategies and Organizational Innovations in Production Networks 6. Explaining Production Networks: Causal Drivers and Competitive Dynamics 7. Whither (De-)Globalized Electronics Production in the 2020s? Current Trajectories and Future Agendas

Read more less

Book SynopsisThrough the lens of Chinese food, the authors address recent theories in social science concerning cultural identity, ethnicity, boundary formation, consumerism and globalization, and the invention of local cuisine in the context of rapid culture change in East and Southeast Asia.

Read more less

Book SynopsisFew entrepreneurs can claim to have actually changed the way we live, but Ray Kroc is one of them. His revolutions in food service automation, franchising, shared national training and advertising have earned him a place beside the men who founded not merely businesses but entire new industries. This book tells his story.

Read more less

Book SynopsisIn this thoroughly updated second edition, Matthias Herdegen provides a comprehensive and contemporary assessment of the regulation of biotechnology processes and products from an international and comparative perspective, complete with analysis of intricate legal and ethical debates.Trade Review‘The 2nd edition of this magisterial work remains an essential reference work on the international law of biotechnology, now updated with the latest developments. The book is and remains a must-read for anyone interested in biotechnology law and a valuable reference guide for experts working in this field.’ -- Prof. Dr. Claudia Seitz, M.A. (London), Professor for Public Law, European Law, International Law and Life Sciences Law at the Faculty of Law of the Private University in the Principality of LiechtensteinTable of ContentsContents: Preface 1. Introduction: regulation of biotechnology, between anxieties and trust in scientific progress 2. Law and ethics: an intriguing interplay 3. Risks, perceptions and the law: regulatory approaches to risk 4. The biotech challenge to human dignity, life and freedom of choice: human rights 5. From test tube babies to human clones: salient issues in the international law of biomedicine 6. GMOs, crops and precaution: biotechnology and international protection of the environment 7. Combating biopiracy: access to genetic resources 8. Phantom risks and legitimate concerns: biotechnology and international trade law 9. Inventors’ claims to life: intellectual property rights and biotechnological inventions 10. Conclusion: legal values, individual rights and democratic choices in a pluralist world Index

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book SynopsisFrom the minute it opened-on Christmas Day in 1865-it was Chicago's must-see tourist attraction, drawing more than half a million visitors each year. Families, visiting dignitaries, even school groups all made trips to the South Side to tour the Union Stock Yard. There they got a firsthand look at the city's industrial prowess as they witnessed cattle, hogs, and sheep disassembled with breathtaking efficiency. At their height, the kill floors employed 50,000 workers and processed six hundred animals an hour, an astonishing spectacle of industrialized death. Slaughterhouse tells the story of the Union Stock Yard, chronicling the rise and fall of an industrial district that, for better or worse, served as the public face of Chicago for decades. Dominic A. Pacyga is a guide like no other-he grew up in the shadow of the stockyards, spent summers in their hog house and cattle yards, and maintains a long-standing connection with the working-class neighborhoods around them. Pacyga takes readers through the packinghouses as only an insider can, covering the rough and toxic life inside the plants and their lasting effects on the world outside. He shows how the yards shaped the surrounding neighborhoods and controlled the livelihoods of thousands of families. He looks at the Union Stock Yard's political and economic power and its sometimes volatile role in the city's race and labor relations. And he traces its decades of mechanized innovations, which introduced millions of consumers across the country to an industrialized food system. Although the Union Stock Yard closed in 1971, the story doesn't end there. Pacyga takes readers to present day, showing how the manufacturing spirit lives on. Ironically, today the site of the legendary stockyard stench is now home to some of Chicago's most successful green agriculture companies. Marking the hundred-and-fiftieth anniversary of the opening of the stockyards, Slaughterhouse is an engrossing story of one of the most important-and deadliest-square miles in American history.

Read more less

Book SynopsisJunkers Military Aircraft of World War Two

Read more less

Book SynopsisThis is a story of how work gets done. It is also a study of how field service technicians talk about their work and how that talk is instrumental in their success. In his innovative ethnography, Julian E. Orr studies the people who repair...Trade ReviewHow ironic, at an historic moment when technology has assumed a taken-for-granted status in the workplace, that scholarship on organizations, work, and technology has only recently begun to find its feet. With this splendid ethnography of work practices by technicians who service photocopy machines, Julian Orr has made a major incursion into this territory, producing a volume that bridges disciplinary boundaries by joining the literature of organizations, occupations, and work with that of science and technology studies. -- Diane Vaughn * Administrative Science Quarterly *This book should be of value to anyone interested in studies of work practice, and to those who study technical work in particular. -- Bonalyn J. Nelsen * Industrial and Labor Relations Review *

Read more less