Magnetic resonance Books

Book SynopsisFor those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage.

Read more less

Book SynopsisFor those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage.Table of ContentsTheoretical and physical aspects of nuclear shielding; Applications of nuclear shielding; Theoretical aspects of spin-spin couplings; Applications of spin-spin coupling; Nuclear spin relaxation in liquids and gases; Solid-state NMR spectroscopy; NMR of proteins and nucleic acids; NMR of carbohydrates, lipids and membranes; Synthetic macromolecules; NMR in living systems; Oriented molecules

Read more less

Book SynopsisThe term magnetic resonance covers a wide range of techniques, spectroscopy, relaxation and imaging. In turn, these areas are evolving and leading to various new applications of NMR and ESR in food science and nutrition. This book is part of the continuing series of proceedings of the biennial conferences on applications of magnetic resonance to food science. As always, the aim of the book is to bring the reader up-to-date with the state-of-the-art of the subject. The speakers came from Europe, North and South America, Asia and Australasia giving a global perspective to the event. The range of the conference was broad covering sensory science, authenticity, functionality, solid state methods and new methods. Magnetic Resonance in Food Science is a global survey written by leading authorities. It provides readers with an awareness of current activity in the field and potential applications.Table of ContentsNew Techniques; Chapter 1: High resolution NMR analysis of complex mixtures; Chapter 2: The quantitative impact of water suppression on NMR spectra for compositional analysis of alginates; Chapter 3: NMR-based metabonomics approaches for the assessment of the metabolic impact of dietary polyphenols on humans; Chapter 4: 1H HR MAS NMR: profiling metabolites in single cereal kernels (of wheat and barley); Chapter 5; Microstructure investigation of concentrated dairy gels by real-time NMR diffusion experiments; Chapter 6: Developments in time domain and single sided NMR; Chapter 7: Investigation of sodium ions in cheeses by Na NMR spectroscopy; Chapter 8 Applications of field cycling relaxometry to food characterization; Chapter 9; A low resolution 1H NMR study to investigate the protective mechanism of sorbitol during vacuum drying of a probiotic micro-organism; Chapter 10: A low-field-NMR capillary rheometer; Chapter 11: Development of a rheo-NMR system to study the crystallisation of bulk lipids under shear flow; Chapter 12: NMR-based Multi Parametric Quality Control of Fruit Juices; Food Systems and Processing; Chapter 13: Effect of soy addition on microwavable parbaked frozen doughs; Chapter 14: Identification and quantification of phosphorus in cheeses - methodological investigations by solid-state 31P NMR spectroscopy; Chapter 15: Using MRI to study tomato fruit; Chapter 16: SNIF-NMR and chemometric methods applied to 1H NMR in the study of brazilian brandy authenticity; Chapter 17: Identification and quantification of major triacylglycerols in selected South African vegetable oils by 13C NMR spectroscopy; Chapter 18: Pomodoro di pachino: an authentication study using 1H-NMR and chemometrics - protecting its P.G.I. European certification; Chapter 19: 1D and 2D 1H-NMR analysis of taste compounds extracted from raw or fried Allium Cepa l. Tissues. Methodological questions; Chapter 20: Analysis of butter and margarine by high-resolution 1H NMR; Chapter 21: Spin-lattice relaxation time measurements as a probe for triacylglycerol polymorphism and crystal size; ESR and Other Techniques; Chapter 22: ESR for food irradiation detection; Chapter 23: Applications of CW-EPR in food quality control and R&D; Chapter 24: Application of electron spin resonance to study food anitoxidative and prooxidative activities; Chapter 25: Water/biopolymer interactions: comparison of NMR with other techniques; Fish and Meat; Chapter 26: Low field NMR study on wild and farmed atlantic cod (Gadus Morhua); Chapter 27: A look at NMR relaxometry applications in meat science - recent advances in coupling NMR relaxometry with spectroscopic, thermodynamic, microscopic and sensory measurements; Chapter 28: Sodium MRI as a tool for optimization of salting processes

Read more less

Book SynopsisReflecting the growing volume of published work in this field, researchers will find this book an invaluable source of information on current methods and applications.Table of ContentsBiological free radicals; time-resolved electron paramagnetic resonance studies in organic photochemistry; radiation damage to DNA and related biomolecules; spin trapping - recent developments and applications; EPR and ENDOR studies of metalloproteins; pulsed ESR of microporous and mesoporous oxide materials; advanced EPR in millimetre bands and very high fields; electron transfer kinetics studied by by EPR/ESR and related methods.

Read more less

Book SynopsisFor those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage.Table of ContentsNMR books and reviews, G. Webb; theoretical and physical aspects of nuclear shielding, Cynthia Jameson; applications of nuclear shielding, M. Yamaguchi; theoretical aspects of spin-spin couplings, H. Fukui; applications of spin-spin coupling constants, K. Kamienska-Trela and James Wojcik; nuclear spin relaxation in liquids and gases, H. Weingartner; solid state NMR, M. Anderson; multiple pulse NMR, L. Lian; natural macromolecules, J. Arnold and J. Fisher; synthetic macromolecules, A. Fawcett; conformational analysis, J. Barker and B. Wood; nuclear magnetic resonance spectroscopy of living systems, M. Prior; nuclear magnetic resonance imaging, S. Williams; NMR of paramagnetic species, R. Sharp; NMR of liquid crystals and micellar solutions, A. Khan.

Read more less

Book SynopsisFor those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage.Table of ContentsNMR books and reviews; theoretical and physical aspects of nuclear shielding; applications of nuclear shielding; theoretical aspects of spin-spin couplings; applcations of spin-spin coupling; nuclear spin relaxation in liquids; solid state NMR; multiple pulse NMR; NMR ofnatural macromolecules; synthetic macromolecules; conformational analysis; nuclear magnetic resonance spectroscopy of living systems; nuclear magnetic resonance imaging; NMR of paramagnetic species; NMR of liquid crystals and micellar solutions.

Read more less

Book SynopsisReflecting the growing volume of published work in this field, researchers will find this book an invaluable source of information on current methods and applications.Table of ContentsFree Radicals in Biomolecular Injury and Disease; Recent Developments in EPR Spin-trapping; Time-resolved EPR Studies of Transient Organic Radicals; Spin Labeling in High-field EPR; Techniques and Applications of EPR Imaging; EPR of Exchange Coupled Oligomers; EPR of Paramagnetic Centres on Solid Surfaces; EPR of Radical-Intermediates in Flavoenzymes; Progress in High-field EPR; Iron Coordination in Metalloproteins: Structural and Electronic Aspects; Author Index.

Read more less

Book SynopsisFor those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage.Table of ContentsNMR books and reviews; theoretical and physical aspects of nuclear shielding; applications of nuclear shielding; theorectical aspects of spin-spin couplings; applications of spin-spin couplings; nuclear spin relaxation in liquids and gases; solid state NMR; multiple pulse NMR; NMR of natural macromolecules; synthetic macromolecules; conformational analysis; nuclear magnetic resonance spectroscopy of living systems; nuclear magnetic resonance imaging; NMR of paramagnetic species.

Read more less

Book SynopsisFor those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage.Table of ContentsNMR reviews; theoretical aspects of nuclear shielding; applications of nuclear shielding; theoretical aspects of spin-spin couplings; applications of spin-spin couplings; nuclear spin relaxation in liquids and gases; solid state NMR; multiple resonance; natural macromolecules; synthetic macromolecules; confomational analysis; high resolution of NMR living systems; nuclear magnetic resonance imaging; NMR of paramagnetic systems; liquid crystals and micellar structures.

Read more less

Book SynopsisFor those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage.Table of ContentsNMR books and reviews, W. Schilf; theoretical and physical aspects of nuclear shielding, C.J. Jameson, A.C. de Dios; applications of nuclear shielding, M. Yamaguchi; theoretical aspects of spin-spin couplings, H. Fukui; applications of spin-spin couplings, K. Kamienska-Trela, Jacek Wojcik; nuclear spin relaxation in liquids and gases, R. Ludwig; solid state NMR, M.E. Smith; multiple pulse NMR, I. Barsukov; NMR of nucleic acids and proteins, P.C. Driscoll et al; NMR of carbohydrates, lipids and membranes, E.F. Hounsell; synthetic macromolecules, H. Kurosu, T. Yamanobe; nuclear magnetic resonance spectroscopy of living systems, M.J.W. Prior; nuclear magnetic resonance imaging, T. Watanabe; oriented molecules, C.L. Khetrapal et al.

Read more less

Book SynopsisFor those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage.Trade Review"Volumes in this series are extremely well referenced and incorporate a tremendous amount of information on NMR..." Carbohydrate Polymers, 39 (1999), pp 291-292"Table of ContentsNMR books and reviews; theoretical and physical aspects of nuclear shielding; applications of nuclear shielding; theoretical aspects of spin-spin couplings; applications of spin-spin couplings; nuclear spin relaxation in liquids and gases; solid state NMR spectroscopy; multiple pulse NMR; NMR of nucleic acids and proteins; NMR of carbohydrates, lipids and membranes; synthetic macromolecules; NMR in living systems; nuclear magnetic resonance imaging; paramagnetic NMR; NMR of liquid crystals and micellar solutions.

Read more less

Book SynopsisFor those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage.Table of ContentsNuclear magnetic resonance books and reviews; theoretical and physical aspects of nuclear shielding; applications of nuclear shielding; theoretical aspects of spin-spin couplings; applications of spin-spin couplings; nuclear spin relaxation in liquids and gases; solid state nuclear magnetic resonance spectroscopy; multiple pulse nuclear magnetic resonance; nuclear magnetic resonance of nucleic acids and proteins; nuclear magnetic resonance of carbohydrates, lipids and membranes; synthetic macromolecules; nuclear magnetic resonance in living systems; nuclear magnetic resonance imaging; oriented molecules

Read more less

Book SynopsisFor those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage.Table of ContentsNMR books and reviews; theoretical and physical aspects of nuclear shielding; applications of nuclear shielding; theoretical aspects of spin-spin couplings; applications of spin-spin couplings; nuclear spin relaxation in liquids and gases; solid state NMR spectroscopy; multiple pulse NMR; NMR of nucleic acids and proteins; NMR of carbohydrates, lipids and membranes; synthetic macromolecules; NMR in living systems; nuclear magnetic resonance imaging; oriented molecules.

Read more less

Book SynopsisFor those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage.Trade Review"Volumes in this series are extremely well referenced and incorporate a tremendous amount of information on NMR ..." * Carbohydrate Polymers, 39 (1999), pp 291-292 *Table of ContentsNMR Books and Reviews; Theoretical and Physical Aspects of Nuclear Shielding; Theoretical Aspects of Spin-Spin Couplings; Applications of Spin-Spin Couplings; Nuclear Relaxation in Liquids and Gases; Solid State NMR Spectroscopy; Multiple Pulse NMR; NMR of Proteins and Nucleic Acids; NMR of Carbohydrates, Lipids and Membranes; Synthetic Macromolecules; NMR in Living Systems; Nuclear Magnetic Resonance Imaging; Oriented Molecules; NMR of Liquid Crystals and Micellar Solutions

Read more less

Book SynopsisFor those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage.Table of ContentsNMR Books and Reviews; Theoretical and Physical Aspects of Nuclear Shielding; Application of Nuclear Shielding; Theoretical Aspects of Spin-Spin Couplings; Applications of Spin-Spin Couplings; Nuclear Spin Relaxation in Liquids and Gases; Solid State NMR Spectroscopy; Multiple Pulse NMR; NMR of Proteins and Nucleic Acids; NMR of Carbohydrates, Lipids and Membranes; Synthetic Macromolecules; NMR in Living Systems; Nuclear Magnetic Resonance Imaging; NMR of Liquid Crystals and Micellar Solutions; Paramagnetic NMR

Read more less

Book SynopsisFor those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage.Table of ContentsChapter 1: Theoretical and physical aspects of nuclear shielding; Chapter 2: Applications of nuclear shielding; Chapter 3: Theoretical aspects of spin-spin couplings; Chapter 4: Applications of spin-spin couplings; Chapter 5: Nuclear spin relaxation in liquids and gases; Chapter 6: Solid state NMR spectroscopy; Chapter 7: Multiple pulse NMR; Chapter 8: NMR of proteins and nucleic acids; Chapter 9: NMR of carbohydrates, lipids and membranes; Chapter 10: Synthetic macromolecules; Chapter 11: NMR in living systems; Chapter 12: Nuclear magnetic resonance imaging; Chapter 13: NMR of liquid crystals and micellar solutions

Read more less

Book SynopsisThe term magnetic resonance covers a wide range of techniques, spectroscopy, relaxation and imaging. In turn, these areas are evolving and leading to various new applications of NMR and ESR in food science and nutrition. From assessment of meat quality, through to a study of beer components and the effect of microwaves on potato texture, Magnetic Resonance in Food Science: Latest Developments provides an account of the state of the art in this lively area. Coverage includes: recent developments in magnetic resonance; human aspects of food; structure and dynamics in food; and food quality control. With contributions from international experts, this book is essential reading for academics and industrialists in food science. It is the latest in a series of titles in this area published by the RSC.Trade ReviewA must for all researchers with a genuine and cosmopolitan interest in all aspects of magnetic resonance. * Journal of the Science of Food and Agriculture, July 2004 (I M Morrison) *The comprehensive, yet specialised nature of this book suggests that it will be of primary interest to academics, material scientists or to forward looking plant managers. * Food Australia 58 (3) - March 2006 (Dr Robert Sleigh) *"... it succeeds admirably in updating the researcher with progress in NMR applications for food science, and in opening up further application possibilities." * Chemistry and Industry, 6 October 2003 *"... of interest to academics and industrialists in food science... " * Carbohydrate Polymers, 55, 2004, 333 *Table of ContentsMagnetic Resonance - The Developing Scene; Food: The Human Aspect; Food: Structure & Dynamics; Food Quality Control; Subject Index.

Read more less

Book SynopsisThis unique book describes the latest information in the fundamental understanding of the biophysics and biochemistry of articular cartilage using the state-of-the-art practices in NMR and MRI. This is the first book of its kind, written by physicists and chemists on this important tissue, whose degradation contributes to osteoarthritis and related joint diseases. Connecting the fundamental science with the clinical imaging applications, the experts Editors provide an authoritative addition to the literature. Ideal for practising physical scientists and radiologists with an interest in the fundamental science as well as instrument manufacturers and clinical researchers working with articular cartilage.Table of ContentsPart One – Introduction: Introduction to Cartilage; Osmotic Properties of Cartilage; Introduction to NMR and MRI; The Magic Angle Effect in NMR and MRI of Cartilage; Part Two – Physical Properties of Cartilage by Relaxation Anisotropy; Experimental NMR and MRI Techniques for Cartilage Research: Physical Properties of Cartilage by Relaxation Anisotropy; Chemical Properties of Cartilage Studied Using Charged Ions; Quantification of Articular Cartilage Microstructure by the Analysis of the Diffusion Tensor; Sodium and Other Exotic Methods in NMR and MRI of Cartilage; Multi-Quantum Filtered NMR and MRI of Cartilage; Solid-State NMR Techniques to Study the Molecular Dynamics in Cartilage; Ultrashort Echo Time Imaging of Articular Cartilage; Low-Field and Field-Cycling NMR and MRI of Cartilage; The Influence of Specimen and Experimental Conditions on NMR and MRI of Cartilage; Part Three – Biomechanical Properties of Cartilage by NMR and MRI; Diffusion MRI and Poroelastic Biomechanics of Articular Cartilage; Combining Multi-Modal MRI and Biomechanical Modeling to Investigate the Response of Cartilage and Chondrocytes to Mechanical Stimuli; Loading-Induced Changes in Cartilage Studied by NMR and MRI; Part Four– Applications and the Future of Cartilage Research by NMR and MRI; The Critical Role of the Imaging Resolution in MRI of Cartilage – The MRI Microscope; Multi-Component Relaxations in MRI of Cartilage; Uni- and Multi-Parametric Magnetic Resonance Analysis of Cartilage; Magnetic Resonance in the Assessment of Tissue Engineered Cartilage; Complementary Imaging in MRI of Cartilage; Quantitative MRI for Detection of Cartilage Damage; Challenges for the Early Detection of Degenerative; Cartilage Changes Using Magnetic Resonance Imaging In vivo in Humans; Ultrahigh-Field Whole-Body MRI for Cartilage Imaging: Technical Challenges

Read more less

Book SynopsisThis volume focuses on solution and solid-state NMR of carbohydrates, glycoproteins, glyco-technologies, biomass and related topics. It is estimated that at least 80% of all proteins are glycoproteins. Because of the complexity, heterogeneity and flexibility of the sugar chains, the structural biology approaches for glycoconjugates have been generally avoided. NMR techniques although well established for structural analyses of proteins and nucleic acids, cannot be simply applied to this complex class of biomolecules. Nonetheless, recently developed NMR techniques for carbohydrates open the door to conformational studies of a variety of sugar chains of biological interest. NMR studies on glycans will have significant impact on the development of vaccines, adjuvants, therapeutics, biomarkers and on biomass regeneration. In this volume, the Editors have collected the most up-to-date NMR applications from experts in the field of carbohydrate NMR spectroscopy. Timely and useful, not only for NMR specialists, it will appeal to researchers in the general field of structural biology, biochemistry and biophysics, molecular and cellular biology and material science.Table of ContentsIntramolecular Hydrogen Bonding in Glycans in Aqueous Solution; NMR Spin-Couplings in Saccharides: Relationships between Structure, Conformation and the Magnitudes of JHH, JCH and JCC Values; Insights into Carbohydrate Recognition by 3D Structure Determination of Protein-Carbohydrate Complexes using NMR; Paramagnetic, RDC and RCSA Constraints in the Structural Analysis of Glycans; Lanthanide-Chelating Carbohydrate Conjugates to Detect Carbohydrate-Protein Interactions; NMR Characterization of the Conformations, Dynamics, and Interactions of Glycosphingolipids; NMR Analysis of Glycosyltransferases; Stable Isotope Labeling of Glycoproteins for NMR Study; Quantifying Carbohydrate Motions Through Solution Measurements: Applications to Immunoglobulin G Fc; Analysis of Glycosaminoglycans by 15N-NMR Spectroscopy; NMR Studies of Protein-Glycosaminoglycan Interactions; Solid-state NMR Analysis of Mannose Recognition by Pradimicin A; Structure and Dynamics of Polysaccharides in Plant Cell Walls From Solid-State NMR; New Methods for the Analysis of Heterogeneous Polysaccharides: Lessons Learned from the Heparin Crisis; NMR Chemical Shift Predictions and Structural Elucidation of Oligo- and Polysaccharides by the Computer Program CASPER; NMR Databases for Plant Cell Wall Biopolymers; Polysaccharides as Major Carbon Sources in Environmental Biodiversity

Read more less

Book SynopsisMagnetic resonance systems are used in almost every academic and industrial chemistry, physics and biochemistry department, as well as being one of the most important imaging modalities in clinical radiology. The design of such systems has become increasingly sophisticated over the years. Static magnetic fields increase continuously, large-scale arrays of receive elements are now ubiquitous in clinical MRI, cryogenic technology has become commonplace in high resolution NMR and is expanding rapidly in preclinical MRI, specialized high strength magnetic field gradients have been designed for studying the human connectome, and the commercial advent of ultra-high field human imaging has required new types of RF coils and static shim coils together with extensive electromagnetic simulations to ensure patient safety. This book covers the hardware and engineering that constitutes a magnetic resonance system, whether that be a high-resolution liquid or solid state system for NMR spectroscopy, a preclinical system for imaging animals or a clinical system used for human imaging. Written by a team of experts in the field, this book provides a comprehensive and instructional look at all aspects of current magnetic resonance technology, as well as outlooks for future developments.Table of ContentsThe principles of magnetic resonance and associated hardware; Magnets; Radiofrequency Coils; B0 Shimming Technology; Magnetic Field Gradients; Radiofrequency amplifiers for NMR/MRI; The MR receiver chain; Electromagnetic modelling;

Read more less

Book SynopsisBeginning with a review of the important areas of mathematics, this book then covers many of the underlying theoretical and practical aspects of NMR and MRI spectroscopy from a maths point of view. Competence in algebra and introductory calculus is needed but all other maths concepts are covered. It will bridge a gap between high level and introductory titles used in NMR or MRI spectroscopy. Uniquely, it takes a very careful and pedagogical approach to the mathematics behind NMR and MRI. It leaves out very few steps, which distinguishes it from other books in the field. The author is an NMR laboratory manager and is sympathetic to the frustrations of trying to understand where some of the fundamental equations come from hence his desire to either explicitly derive all equations for the reader or direct them to derivations. This is an essential text aimed at graduate students who are beginning their careers in NMR or MRI spectroscopy and laboratory managers if they need an understanding of the theoretical foundations of the technique.Trade ReviewExcellent for many aspects of NMR spectroscopy, including the treatment of product operator formalism and density matrix. -- Gianluigi Veglia * University of Minnesota *The tallest hurdle faced by practitioners of NMR and MRI, is an understanding of the high level mathematics needed to describe the techniques.There are many papers and books on magnetic resonance which present either over-simplistic explanations, in order to avoid the detailed mathematics, or provide very detailed descriptions without an adequate explanation of the mathematics employed. Essential Mathematics for NMR and MRI Spectroscopists is the first book to addresses these problems in a comprehensive manner. The only prerequisites for the reader are an undergraduate level of mathematics and a general familiarity of the fundamentals of NMR spectroscopy. With the end goal being a detailed understanding of NMR and MRI, the first third of the book introduces all of the necessary mathematics required to understand the chapters thereafter. Those with a good undergraduate foundation in mathematics will find most of this to be a useful review but will likely learn more. The concepts of complex numbers, vectors, matrices, linear algebra, calculus, probability and statistics are reviewed in detail. With very few exceptions, all derivations are explicit and easy to follow. Frequent reference is made to a very well written appendix providing details for identities, theorems and concepts used. After the mathematics is introduced, classical and quantum mechanics are described in sufficient detail to understand their relevance and application to the theory of NMR spectroscopy which is the subject of all but the last of the remaining chapters of the book. The last chapter is devoted to electronics – a subject of much relevance to NMR laboratory technical staff. Very detailed descriptions of the Bloch equations, angular momentum, Hamiltonian operators, density matrices, product operators, coherence transfer, relaxation, nuclear Overhauser effects and magnetic resonance imaging are given for which the reader will have a new appreciation and greater understanding from a mathematical perspective. This well written book is a valuable resource for graduate students, post-doctoral fellows, university faculty members and NMR practitioners in search of a deeper understanding of magnetic resonance theory. It is ideally suited as a textbook for graduate level courses in NMR theory and must certainly be added as additional reading for any other course in NMR spectroscopy. Unlike many books on mathematics and physics, this book is relatively easy to read. The author has sprinkled the text generously with insightful (and often amusing) footnotes bringing a personal perspective to the material. -- Glenn A. Facey, NMR Facility Manager, University of OttawaTable of ContentsComplex Numbers; Matrices; Vectors; Vector Calculus; Tensor Analysis; Probability and Statistics; Waves; Fourier Transforms; Classical Mechanics; Special Relativity; Electric and Magnetic Fields; The Magnetic Moment and the Bloch Equations; Quantum Mechanics; The Hamiltonians of NMR; The Quantum Mechanics of Angular Momentum; NMR Rotation Operators; Density Operators; The Product Operator Formalism; Relaxation and the NOE; Data Processing; Coherence Transfer; Electronics; Appendices

Read more less

Book SynopsisNuclear magnetic resonance has proved a uniquely versatile and powerful spectroscopic technique, with applications across chemistry, physics and medicine. The success of NMR and its constant redevelopment means that the literature is vast and wide-ranging. Each chapter in this volume is a distillation of the key recent literature in different areas covering the spectrum of NMR theory and practice, and including solution-state, solid-state and in-vivo NMR. These reports will be invaluable both for new researchers wishing to engage with literature for the first time, and for seasoned practitioners, particularly service managers, wishing to keep in touch with the ever-expanding ways in which NMR is used.Table of ContentsTheory and Computation of Nuclear Shielding; Theoretical and Practical Aspects of Indirect Spin-Spin Couplings; Nuclear Spin Relaxation; Solid-State NMR Spectroscopy; Recent Development and Applications of NMR in Industry; NMR of Soft Matter Systems; NMR of Proteins and Nucleic Acids; NMR in Living Systems

Read more less

Book SynopsisParamagnetic NMR is a growing technique that represents an increasingly important tool for the investigation of biomolecules. This book presents an update and overview of the paramagnetic NMR phenomena and effects as well as guidelines for practical implementation of state-of-the-art experiments. All experiments are supported by a solid theoretical foundation. Areas mentioned are the development of solid state NMR, the use of paramagnetic tags providing information on the structure and mobility of the investigated systems, and dynamic nuclear polarization to increase sensitivity. Compiled by experts in the field, this book has international appeal for researchers as well as students interested in magnetic resonance and structural biology who require experimental support and accessible information.Table of ContentsNMR Consequences of the Nucleus-Electron Spin Interactions; Intrinsic and Extrinsic Paramagnetic Probes; Structural and Dynamic Characterization of Protein Domains Using Paramagnetic Data; Treating Biomacromolecular Conformational Variability; Protein-Protein Interactions; Solid-State NMR of Paramagnetic Proteins; Relaxometry and Contrast Agents; Dynamic Nuclear Polarization; Paramagnetic NMR in Drug Discovery; Small Paramagnetic Co-solute Molecules; Subject Index

Read more less

Book SynopsisGels are used in a large variety of commercial and scientific products from drug delivery systems and food science to biomedical sensors. They also are invaluable in MRI physics research where they mimic biological tissue and in radiotherapy quality assurance where they are used to capture the three dimensional radiation dose distribution. This unique book discusses the state-of-the-art of NMR and MRI techniques in studying the physics and chemistry of gel systems, in their application as MRI phantoms and as three dimensional radiation dosimeters. The first part of the book will cover the fundamental physical concepts of gels and the NMR techniques to study gel systems. The second part is dedicated to the application of gels in the life sciences and in the medical practice to validate radiotherapy and new MRI techniques. Filling the gap in literature, this volume provides the scientific reader with an extensive overview of possible techniques and methods to study the interesting properties and applications of gels. For the MRI researcher and medical physicist, the book will be a valuable resource in using gel phantoms for validating contemporary MRI techniques and radiotherapy treatments.Table of ContentsGels; NMR Spectroscopy in the Study of the Structure and Dynamics of Gels; NMR Diffusion Measurements; Magnetic Resonance Micro-Imaging of Hydrogels; NMR of Supramolecular Gels; Multinuclear and Solid State NMR of Gels; Cells in Gels: NMR Studies; NMR in Food Technology; Gel based Radiation Dosimetry using Quantitative MRI; Gel Phantoms for MRI Quality Assurance and Testing; Gel Phantoms for Diffusion MRI Studies; Gel Phantoms for Dynamic Contrast Enhanced MRI and Fluor-19 MRI Oximetry

Read more less

Book SynopsisField-cycling NMR relaxometry is evolving into a methodology of widespread interest with recent technological developments resulting in powerful and versatile commercial instruments. Polymers, liquid crystals, biomaterials, porous media, tissue, cement and many other materials of practical importance can be studied using this technique. This book summarises the expertise of leading scientists in the area and the editor is well placed, after four decades of working in this field, to ensure a broad ranging and high quality title. Starting with an overview of the basic principles of the technique and the scope of its use, the content then develops to look at theory, instrumentation, practical limitations and applications in different systems. Newcomers to the field will find this book invaluable for successful use of the technique. Researchers already in academic and industrial settings, interested in molecular dynamics and magnetic resonance, will discover an important addition to the literature.Table of ContentsPrinciple, Purpose and Pitfalls of Field-cycling NMR Relaxometry; Essentials of the Theory of Spin Relaxation as Needed for Field-cycling NMR; New Trends in Field-cycling NMR Technology; Broadband Fast Field-cycling Relaxometer: Requirements, Instrumentation and Verification; Specific Aspects of the Design of Field-cycling Devices; Signal Enhancement for Fast Field-cycling Relaxometry by Dynamic Nuclear Polarization: Basic Principles, Hardware and Methods; Relaxometry at Very Low Frequencies by Rotating-frame Techniques for Complementing the Frequency Domain Explored by Field Cycling; Application of Field-cycling 1H NMR Relaxometry to the Study of Translational and Rotational Dynamics in Liquids and Polymers; Nuclear Magnetic Relaxtion Dispersion of Water-Protein Systems; Environmental Applications of Fast Field-cycling NMR Relaxometry; NMR Relaxometry in Liquid Crystals: Molecular Organization and Molecular Dynamics Interrelation; Interfacial and Intermittent Dynamics of Water in Colloidal Systems as Probed by Fast Field-cycling Relaxometry; Field-cycling Relaxometry of Polymers; Techniques and Applications of Field-cycling Magnetic Resonance in Medicine; High-resolution Applications of Shuttle Field-cycling NMR; Quantum Molecular Tunnelling Studied by Field-cycling NMR; Paramagnetic Complexes and Superparamagnetic Systems; Probing the Dynamics of Petroleum Fluids in Bulk and Confinement by Fast Field-cycling Relaxometry; Applications of Field-cycling NMR Relaxometry to Cement Materials; Application of Fast Field-cycling NMR Relaxometry to Soil Material; Fast Field-cycling NMR Experiments with Hyperpolarized Spins; Subject Index

Read more less

Book SynopsisIn-cell NMR spectroscopy is a relatively new field. Despite its short history, recent in-cell NMR-related publications in major journals indicate that this method is receiving significant general attention. This book provides the first informative work specifically focused on in-cell NMR. It details the historical background of in-cell NMR, host cells for in-cell NMR studies, methods for in-cell biological techniques and NMR spectroscopy, applications, and future perspectives. Researchers in biochemistry, biophysics, molecular biology, cell biology, structural biology as well as NMR analysts interested in biological applications will all find this book valuable reading.Table of ContentsIn-cell NMR Spectroscopy: From 2001 to Now; Protein NMR in Escherichia coli; In-cell NMR in Eukaryotic Cells - I (Introduction from Outside of Cells); In-cell NMR in Eukaryotic Cells - II (Direct Protein Expression); Protein Structure Determination in Living Cells from NOE-derived Distance Restraints; In-cell Structure Determination Using Paramagnetic NMR Spectroscopy; Bioreactor System for In-cell NMR Observation; 19F In-cell NMR; Cellular Solid-state NMR Spectroscopy; In-cell EPR; In-cell NMR: Spectral Optimization and Population Adjustment by Rational Protein Engineering; Protein Stability and Weak Intracellular Interactions; Protein Folding, Maturation and Redox State; All-atom Molecular Dynamics Simulation of Proteins in Crowded Environments; Primary Drug Screening by In-cell NMR Spectroscopy; In-cell NMR Spectroscopy of Nucleic Acids

Read more less

Book SynopsisSince the introduction of FT-NMR spectroscopy around five decades ago, NMR has achieved significant advances in hardware and methodologies, accompanied with the enhancement of spectral resolution and signal sensitivity. Rapid developments in the polymers field mean that accurate and quantitative characterization of polymer structures and dynamics is the keystone for precisely regulating and controlling the physical and chemical properties of the polymer. This book specifically focuses on NMR investigation of complex polymers for the polymer community as well as NMR spectroscopists, and will push the development of both fields. It covers the latest advances, for example high field DNP and ultrafast MAS methodologies, and show how these novel NMR methods characterize various synthetic and natural polymers.Table of ContentsApplications of NMR in Polymer Characterization - An Introduction; Application of STD NMR in Organic/Inorganic Polymer Materials; Diffusion and Relaxometry to Study Carbohydrates Dissolved in Ionic Liquids; High Resolution Magic Angle Spinning (HRMAS) Pulse Field Gradient (PFG) NMR Diffusometry Studies of Swollen Polymers; Application of On-line SEC-NMR and DOSY for Practical Polymer Characterization; Dynamics of Polymer Systems Studied by NMR Field-cycling Relaxometry; HR-MAS NMR Characterization of Thermo-responsive Polymer Gels: Network Collapse Dynamics and Intermolecular Interactions; Rubber-state NMR Spectroscopy; Polymer Blends, Nanocomposites, Rubbers and p-Conjugated Polymers; NMR Investigations of Interfaces in Tapered and Inverse-tapered Copolymers in the Solid State; Nanostructures, Conformations, and Intermolecular Interactions in Natural Biopolymers Revealed by Solid-state NMR Spectroscopy; Chain Proximity of Polystyrene in Bulk Polymer, Polymer Blend and Nanocomposites; Dipolar Based NMR Methods for Probing Intermediate Regime Motions in Polymers; Structure and Molecular Dynamics of Semicrystalline Polymers as Studied by Solid-state NMR; Solid-state NMR of Organic Electronics; Molecular Chain Packing and Conformation in p-Conjugated Polymers from Solid-state NMR; Applications of Solid-state NMR in Crystalline Solid Polymer Electrolytes; NMR Characterization of Silk; Solid-state NMR and Membrane Proteins: Key Interactions in Biomacromolecules; Development of Sulfur-33 Nuclear Magnetic Resonance for Structural Study of Crosslinked Rubber; Very Fast MAS NMR >60 kHz for Structural Elucidation; Structural Investigations of Polymer Materials by Dynamic Nuclear Polarisation Solid-state NMR

Read more less

Book SynopsisThe idea that a long-lived form of spin order, namely singlet order, can be prepared from nuclear spin magnetisation first emerged in 2004. The unusual properties of singlet order–its long lifetime and the fact that it is NMR silent but interconvertible into other forms of NMR active order—make it a ‘smart tag’ that can be used to store information for a long time or through distant space points. It is not unexpected then, that since its first appearance, this idea has caught the attention of research groups interested in exploiting this form of order in different fields of research spanning from biology to materials science and from hyperpolarisation to quantum computing. This first book on the subject gives a thorough description of the various aspects that affect the development of the topic and details the interdisciplinary applications. The book starts with a section dedicated to the basic theories of long-lived spin order and then proceeds with a description of the state-of-the-art experimental techniques developed to manipulate singlet order. It then concludes by covering the generalization of the concept of singlet order by introducing and discussing other forms of long-lived spin order.Table of ContentsLong-lived States in Nuclear Magnetic Resonance: An Overview; Symmetry and Long-lived Spin Order; Relaxation Theory of Long-lived Spin Order; Design and Synthesis of Molecules Supporting Long-lived Spin Order; Manipulation of Singlet Order by Field-cycling; Manipulating Singlet Order by Chemical Reactions; Manipulating Spin Order by J-synchronised Echo Schemes; Manipulating Singlet Order by Spin-lock Induced Crossing; Manipulating Singlet Order with Adiabatic Pulses; Filters for Long-lived Spin Order; Converting Spin Order from Singlet to Heteronuclear Magnetisation; Long-lived States-based Determination of Ligand Affinity for a Target Protein; Applications of Singlet Order to the Study of Biomolecules and Molecular Interactions; Singlet-assisted Exchange NMR Spectroscopy; Singlet-assisted Diffusion NMR; Q-space Singlet NMR; Long-lived Singlet State: From NMR Quantum Information Perspectives; Singlet Spin Order Originating from Para-H2; Long-lived Spin Order Coupled to SABRE; Long-lived Coherences; Long-lived Spin Order in Methyl Groups; Long-lived Spin Order in CH2D Groups; Singlet Order in Heteronuclear Spin Systems

Read more less

Book SynopsisThe medical MRI community is by far the largest user of diffusion NMR techniques and this book captures the current surge of methods and provides a primary source to aid adoption in this field. There is a trend to adapting the more advanced diffusion encoding sequences developed by NMR researchers within the fields of porous media, chemical engineering, and colloid science to medical research. Recently published papers indicate great potential for improved diagnosis of the numerous pathological conditions associated with changes of tissue microstructure that are invisible to conventional diffusion MRI. This book disseminates these recent developments to the wider community of MRI researchers and clinicians. The chapters cover the theoretical basis, hardware and pulse sequences, data analysis and validation, and recent applications aimed at promoting further growth in the field. This is a fast moving field and chapters are written by key MRI scientists that have contributed to the successful translation of the advanced diffusion NMR methods to the context of medical MRI, from global locations.Table of ContentsDiffusion Encoding with General Gradient Waveforms; Diffusion Anisotropy and Tensor-valued Diffusion Encoding; Restricted Diffusion and Spectral Content of the Gradient Waveforms; Disentangling Intercompartment Exchange from Restricted Diffusion; Resolving Incoherent Flow from Diffusion Using Velocity-compensated Diffusion Encoding; Estimating Chemical and Microstructural Heterogeneity by Correlating Relaxation Rates and Diffusion Tensors; Hardware for Generating Modulated Gradient Waveforms with High Precision; Pulse Sequences Combining Advanced Diffusion Encoding and Image Read-out; Diagnosing and Alleviating Imaging Artifacts from Eddy Currents and Concomitant Gradients; Nonparametric Inversion of Advanced Diffusion Data; Model-based Analysis of Advanced Diffusion Data; Phantoms for Validating Advanced Diffusion Sequences; Correlating Advanced Diffusion MRI with Histology

Read more less

Book SynopsisThis book details the latest research and development in the use of magnetic resonance imaging and spectroscopy as tools to give quantitative insights concerning late stage pharmaceutical formulation, tablet manufacturing and drug dissolution behaviour.

Read more less

Book SynopsisWith applications across chemistry, physics and medicine, nuclear magnetic resonance is a proven, uniquely versatile and powerful spectroscopic technique. The success of NMR and its constant redevelopment means that the literature is vast and wide-ranging. Each chapter in this volume is a distillation of the key recent literature in different areas, covering the spectrum of NMR theory and practice, and including theory and computation of nuclear shielding, NMR of soft matter, hyperpolarisation techniques and NMR of living systems. These reports are invaluable both for new researchers wishing to engage with literature for the first time, and for seasoned practitioners, particularly service managers, needing to keep in touch with the ever-expanding ways in which NMR is used.Table of ContentsTheory and computation of nuclear shielding;Theoretical and practical aspects of indirect spin–spin couplings; Nuclear spin relaxation;Advances in NMR spectroscopy of small molecules in solution;Solid-state NMR spectroscopy;Hyperpolarisation techniques;NMR of soft matter systems;NMR of proteins and nucleic acids;NMR in living systems

Read more less

Book SynopsisModern research in biology increasingly relies on multiple techniques for describing structures and mechanisms. This book provides an overview of the contemporary integrated biology approaches for solving structures and understanding mechanisms of complex biological systems. It includes several methodology chapters discussing the current developments in the areas of cryo-electron microscopy (EM) and cryo-electron tomography (ET), computational biophysics, solution NMR spectroscopy, solid-state NMR spectroscopy and dynamic nuclear polarization (DNP), electron paramagnetic resonance (EPR), (photo-)chemically induced dynamic nuclear polarization (CIDNP), X-ray crystallography and small-angle X-ray and neutron scattering (SAXS/SANS). Several subsequent chapters demonstrate how these methods are used in synergy to address problems at the forefront of structural biology, with particular emphasis on examples where individual techniques are insufficient. Examples of biological systems include membrane proteins, viral protein assemblies, cytoskeleton protein assemblies, photosynthetic reaction centers, large enzyme complexes and whole cells. The book is targeted to both the current practitioners of structural biology and scientists who are interested in entering the fields of structural biology or biophysical chemistry.Table of ContentsDecoding Atomic Addresses: Solution NMR Resonance Assignment of Proteins;Solid-state NMR Spectroscopy and Dynamic Nuclear Polarization;Electron Paramagnetic Resonance in Structural Biology;Cryo-electron Microscopy and Tomography: Going for Atomic Resolution in Macromolecular Assemblies and Entire Cells;In-cell Structural Biology Through the Integration of Solution NMR Spectroscopy and Computational Science;Solid-state NMR Based Integrative Structural Methods for Protein and Viral Assemblies;Time-resolved Crystallography on Protein Photoreceptors and Enzymes;Integrative Structural Biology of Enzyme Active Sites;Mechanistic Studies of Membrane Proteins Using Integrated Solid-state NMR and Computational Approaches;Structural Elucidation Based on Photo-CIDNP NMR;Unsupervised Refinement of Protein Structures;RNA Heterogeneity Visualized Under AFM

Read more less

Book SynopsisNMR spectroscopy has found a wide range of applications in life sciences over recent decades. Providing a comprehensive amalgamation of the scattered knowledge of how to apply high-resolution NMR techniques to biomolecular systems, this book will break down the conventional stereotypes in the use of NMR for structural studies. The major focus is on novel approaches in NMR which deal with the functional interface of either protein-protein interactions or protein-lipid interactions. Bridging the gaps between structural and functional studies, the Editors believe a thorough compilation of these studies will open an entirely new dimension of understanding of crucial functional motifs. This in turn will be helpful for future applications into drug design or better understanding of systems. The book will appeal to NMR practitioners in industry and academia who are looking for a comprehensive understanding of the possibilities of applying high-resolution NMR spectroscopic techniques in probing biomolecular interactions.Table of ContentsTheory and Applications of NMR Spectroscopy in Bio Molecular Structures and Dynamics of Proteins; Multi-state Structures and Dynamics at Atomic Resolution Using Exact NOEs; Protein Backbone and Side-chain 15N Spin Relaxation Techniques to Study Biomacromolecular Interactions; Lineshape Analysis as a Tool for Probing Functional Motions at Biological Interfaces; Monitoring Interfaces of Thermo- and pH-responsive Polymers using Solvent Relaxation; NMR-based Ligand–Receptor Interaction Studies under Conventional and Unconventional Conditions; Multi-frequency Saturation Transfer Difference NMR to Characterize Weak Protein–Ligand Complexes; Structural Insight into the Slowly Exchanging Dark States at the Functional Interaction Interface; Dynamics of Protein–Nanoparticle Interactions Using NMR; NMR Structures, Dynamics and Interactions of Protein Complexes in B2 Integrins; Describing Dynamic Chaperone–Client Complexes by Solution NMR Spectroscopy; Methyl-TROSY NMR Spectroscopy in the Investigation of Allosteric Cooperativity in Large Biomolecular Complexes; Characterizing Conformational Diversity of G Protein-coupled receptors by Solution NMR Spectroscopy; Characterising Intrinsically Disordered Proteins using NMR Spectroscopy and Molecular Dynamics Simulations; Structure- and Dynamics-guided Drug Development Using NMR and its Application to Diverse Pharmaceutical Modalities; Locating Hydrogen Atoms Using Fast-MAS Solid-state NMR and MicroED; Membranes, Minerals and Magnets: Application of NMR Spectroscopy to Biological Interfaces; Solid-state NMR Shows that the Structure and Dynamics of Specific Residues in the Membrane Receptor CXCR1 are Altered by Interactions with Specific Residues in its Agonist IL-8; High-resolution NMR Studies of Antibiotics in Membranes; New Concepts for the Mechanisms of Action of Antimicrobial Peptides from Solid-state NMR Investigations; Structure and Dynamics of Native Biological Materials by Solid-state NMR Spectroscopy; The Lipid Phase of the Stratum Corneum Studied by Solid-state NMR: A Not So Rigid Barrier

Read more less

Book SynopsisMolecular chaperones are critical to control protein quality in all living cells. Understanding chaperone function at the atomic level, and in particular its mode of interaction with client proteins, is crucial to understanding the fundamental roles chaperones play in biology. This book fills a gap in the literature by comprehensively summarizing and discussing new advanced experimental techniques for their analysis. Providing a comprehensive overview of advanced biophysical methods for the characterization of molecular mechanisms of molecular chaperones, the majority of the contributions are NMR methodology. This is the method of choice for atomic resolution studies of such systems. Additional notable biophysical approaches are considered to present all relevant current developments in exploring chaperone function and the transient and dynamic interactions with their client proteins. The book is targeted at both current practitioners of structural biology and biophysical chemistry and scientists who are interested in entering the field. It could be useful for graduate students as supplementary reading.Table of ContentsIntroduction: Molecular Chaperones and Protein Quality Control;Structural Disorder in Chaperone Functions Probed by NMR;Solution NMR Approaches for Studying Molecular Chaperones;Solution NMR Studies of Chaperone–Client Systems;Preparing Chaperone–Client Protein Complexes for Biophysical and Structural Studies;NMR Study of Structure and Dynamics of Chaperone–Client Complexes;Single Molecule Fluorescence Methods for Molecular Chaperones and their Client Interactions;Visualization of Chaperone Mediated Protein Folding Using X-ray Crystallography;Studying Molecular Chaperones and their Client Interactions by Nanometer Distance Restraints from Electron Paramagnetic Resonance Spectroscopy;EPR Studies of Chaperone Interactions and Dynamics;Probing Single Chaperone Substrates;Integrative Methods to Investigate Chaperones in Regulating Protein Phase Separation and Aggregation;Structural Biology in Cells by In-cell NMR

Read more less

Book SynopsisNuclear magnetic resonance has proved a uniquely versatile and powerful spectroscopic technique, with applications across chemistry, physics and medicine. The success of NMR and its constant redevelopment means that the literature is vast and wide-ranging. Each chapter in this volume is a distillation of the key recent literature in different areas covering the spectrum of NMR theory and practice, and including solution-state, solid-state and in-vivo NMR. These reports will be invaluable both for new researchers wishing to engage with literature for the first time, and for seasoned practitioners, particularly service managers, wishing to keep in touch with the ever-expanding ways in which NMR is used.Table of ContentsTheory and Computation of Nuclear Shielding; Theoretical and Practical Aspects of Indirect Spin–Spin Couplings; Nuclear Spin Relaxation; Solid State NMR Spectroscopy; Hyperpolarisation Techniques; NMR of Soft Matter Systems; NMR of Proteins and Nucleic Acids; NMR in Living Systems

Read more less

Book SynopsisWritten by active investigators in the field, this book describes state-of-the-art methods that can accelerate the acquisition of 2D NMR spectra in solution-state NMR. The acquisition of fast multi-dimensional NMR data has motivated numerous ground-breaking developments in NMR pulse sequences and associated data processing methods. These in turn have revolutionized the way 2D NMR acquisitions are performed, at the same time broadening the scope of applications of 2D NMR. The first part of the book provides an in-depth description of the concepts and implementation of major fast 2D NMR methods. The second part follows with illustrations of how such methods can be used in applications that require the acquisition of fast 2D NMR spectra, from reaction monitoring to hyperpolarization, including applications to a broad variety of samples and experimental conditions. Appealing to readers from both the methodology and applications communities, this title will fill a gap in the market for a book focused on small molecule NMR, and researchers from both academia and industry will find a rich plethora of knowledge.Table of ContentsThe Role of Pulsed Field Gradients in Modern NMR Pulse Sequence Design;Top Resolution in 2D NMR Spectroscopy Using Spectral Aliasing; Fast Pulsing 2D NMR Methods;Multi-FID Detected 2D NMR;The Non-uniform Sampling of 2D NMR Data;Signal Processing for Highly Resolved 2D NMR;Ultrafast 2D NMR;Pure Shift 2D NMR Spectroscopy;Fast 2D NMR for Reaction and Process Monitoring;Fast 2D NMR to Investigate Dynamic Events in Biomolecules;Application of Fast 2D NMR Methods in the Pharmaceutical Industry;Fast 2D NMR and Hyperpolarization;Fast 2D NMR for Metabolomics;Fast Multi-dimensional NMR for In Vivo Spectroscopy;Combining Fast 2D-NMR Methods and Oriented Media;Fast 2D NMR in Inhomogeneous Magnetic Fields;Fast 2D NMR to Study Microstructures

Read more less

Book SynopsisResidual dipolar couplings (RDCs) are NMR measurements widely used to determine structural and dynamic information in small molecules and large macromolecules. This book provides a broad view of RDCs, from basic principles to advanced applications in organic molecules and biomolecules. Exploring the newest developments in RDC measurement and analysis through authoritative accounts written by leaders in the field, this book provides a comprehensive overview on the fundamentals, analysis and applications in one place for the first time. The versatility and accuracy of RDCs have found a large range of applications in NMR, and their measurement and analysis are major research areas. Readers, be they experts or students, will receive a strong understanding of the fundamentals of RDCs and their applications to their research projects.Table of ContentsIntroduction to Residual Dipolar Coupling;Theoretical Aspects of Residual Dipolar Couplings;External Media for Inducing Weak Alignment in Biomacromolecules;Generating Independent RDCs Using Paramagnetic Tags;Prediction of Weak Alignment from Molecule Structure;NMR Experiments for Measuring RDCs in Biomolecules;Study of Biomolecular Structure and Dynamics with Xplor-NIH;RDC for Membrane Proteins;Consistent Protein Structure Determination Using Sparse NMR Data;RNA Conformational Ensembles from NMR Residual Dipolar Couplings;Structure Determination of Organic Molecules Using RDCs (and RCSAs);Using RDCs and PCSs to Study Structure, Dynamics, and Interactions of Carbohydrates;Anisotropic NMR Methods: Orthogonal Verification of Novel and Complex Natural Product Structures

Read more less

Book SynopsisThis book is devoted to presenting current progress in the NMR studies of molecular chirality.

Read more less

Book SynopsisThis book consists of a series of lectures introducing what the author believes to be the theoretical minimum for the understanding of nuclear spin dynamics, the branch of physics underpinning magnetic resonance techniques such as NMR and MRI. Spin dynamics ultimately concern the study of the state and time evolution of systems made by a large collection of particles possessing spin, one of the most subtle and indeed fascinating concepts in relativistic quantum mechanics and whose understanding requires a mix of quantum mechanics, Hamiltonian dynamics and advanced mathematics. Written in the concise and direct style appropriate for university lectures, this book is addressed to both undergraduate and postgraduate students who are approaching magnetic resonance studies and want to reach the theoretical minimum required to understand the wider topic and its main applications. The book is suitable for researchers who work in the field of magnetic resonance and want to know more about its theoretical fundamentals. Finally, built as a complete set of 12 lectures and 4 workshops, the book can act as a solid reference to lecturers of magnetic resonance university modules. Trained in a world-leading research laboratory internationally recognised for its contributions to the NMR field, the author has a track record in theoretical and methodological developments of nuclear spin dynamics. In this book, he tries to merge his passion for the understanding of physics through its mathematical rendering with his personal quest for the elegance of a clean, clear and satisfactory explanation.Table of ContentsLecture 1: Operator and Superoperator Algebra; Lecture 2: Spin; Lecture 3: The Quantum Description of an Isolated Spin-1/2; Lecture 4: Irreducible Spherical Tensors; Lecture 5: Perturbation Methods; Lecture 6: The Spin Hamiltonian; Lecture 7: The Radiofrequency Hamiltonian and the Rotating Frame; Lecture 8: The Dynamics of an Isolated Spin-1/2; Lecutre 9: The Density Operator; Lecture 10: The Dynamics of a Single Spin-1/2 Ensemble; Lecture 11: The Dynamics of an Ensemble of Coupled Spin-1/2 Pairs; Lecture 12: A Relaxation Theory of Nuclear Spin States; Workshop 1: Spin States and Operators; Workshop 2: Spherical Tensors and Spin Hamiltonians; Workshop 3: The Dynamics of Single Spin-1/2 Systems; The Dynamics of an Ensemble of Spin-1/2 Pairs and Spin Relaxation

Read more less

Book SynopsisWith applications across chemistry, physics and medicine, nuclear magnetic resonance is a proven, uniquely versatile and powerful spectroscopic technique. The success of NMR and its constant redevelopment means that the literature is vast and wide-ranging. Each chapter in this volume is a distillation of the key recent literature in different areas, covering the spectrum of NMR theory and practice, and including solid-state NMR, solution NMR of small molecules and NMR of living systems. These reports are invaluable both for new researchers wishing to engage with literature for the first time, and for seasoned practitioners, particularly service managers, needing to keep in touch with the ever-expanding ways in which NMR is used.Table of ContentsTheory and computation of nuclear shielding;Theoretical and practical aspects of indirect spin–spin couplings;Nuclear spin relaxation;Advances in NMR spectroscopy of small molecules in solution;Solid-state NMR spectroscopy;Hyperpolarisation techniques;NMR of soft matter systems;NMR of proteins and nucleic acids;NMR in living systems

Read more less

Book SynopsisAs a spectroscopic method, nuclear magnetic resonance (NMR) has seen spectacular growth, both as a technique and in its applications. Today's applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive coverage of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules, which is covered in two reports: NMR of Proteins and Nucleic Acids and NMR of Carbohydrates, Lipids and Membranes. For those wanting to become rapidly aquainted with specific areas of NMR, Nuclear Magnetic Resonance provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an invaluable source of current methods and applications.Table of ContentsPreface; Books and Reviews; Theoretical and Physical Aspects of Nuclear Shielding; Applications of Nuclear Shielding; Theoretical Aspects of Spin-Spin Couplings; Applications of Spin-Spin Couplings; Solid State NMR Spectroscopy; NMR of Proteins and Nucleic Acids; NMR of Carbohydrates, Lipids and Membranes; Synthetic Macromolecules; NMR in Living Systems; Nuclear Magnetic Resonance Imaging; NMR of Liquid Crystals and Micellar Solutions; Oriented Molecules

Read more less

Book SynopsisAs a spectroscopic method, nuclear magnetic resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive coverage of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: ""NMR of Proteins and Nucleic Acids"" and ""NMR of Carbohydrates, Lipids and Membranes"". For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an invaluable source of current methods and applications.Table of ContentsNMR books and reviews; Theoretical and physical aspects of nuclear shielding; Applications of nuclear shielding; Theoretical aspects of spinspin couplings; Decomposition of Jinto orbital contributions using orbital currents and partial spin polarization method; Computational study of CC spinspin coupling constants; Applications of spinspin couplings; Solidstate NMR spectroscopy; NMR of proteins and nucleic acids; NMR of carbohydrates lipids and membranes; Synthetic macromolecules; NMR in living systems; Nuclear magnetic resonance imaging; NMR of liquid crystals and micellar solutions; Nuclear spin relaxation in liquids and gases; Selected applications of nuclear spin relaxation

Read more less

Book SynopsisAs a spectroscopic method, nuclear magnetic resonance (NMR) has seen spectacular growth, both as a technique and in its applications. Today's applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive coverage of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules, which is covered in two reports: NMR of Proteins and Nucleic Acids and NMR of Carbohydrates, Lipids and Membranes. In his foreword to the first volume, the then editor, Professor Robin Harris announced that the series would be a discussion on the phenomena of NMR and that articles will be critical surveys of the literature. This has certainly remained the case throughout the series, and in line with its predecessors, Volume 40 aims to provide a comprehensive coverage of the relevant NMR literature. For the current volume this relates to publications appearing between June 2009 and May 2010 (the nominal period of coverage in volume 1 was July 1970 to June 1971). Compared to the previous volume there are some new members of the reporting team. Theoretical Aspects of Spin-Spin Couplings are covered by J. Jazwinski, while E. Swiezewska and J.W¾jcik provide an account of NMR of Carbohydrates, Lipids and Membranes.Trade ReviewThe fields chosen are all very active, ranging over physical, organic, analytical and biological chemistry.the volume proves a useful snapshot of the work done in a particularfield and thus it is a helpful entry into the literatureThis reference work is produced to a high quality The book provides a comprehensive compilation of the literature over the designated 12-month period the volume proves a useful snapshot of the work done in a particular field and thus it is a helpful entry into the literature from which more infonnation could be obtained. Given the diverse subject matter of the various chapters. This reference work is produced to a high quality -- John C. Lindon * Chromatographia (2012) 75:559-560 DOl 10. 1007/s 10337-012-2209-5 *This volume is a compilation and summary of the nuclear magnetic resonance (NMR) spectroscopy literature from June 2009 to May 2010 and is the latest in a long line of similar volumes, the first being published in 1972. Selected aspects of NMR spectroscopy are chosen for each volume, because it would indeed be impossible to cover the whole of the NMR literature for even one year in a single volume. In this edition, the first chapter lists NMR books and reviews for the period in question, these alone providing 635 references. The next two chapters describe research into theoretical and physical aspects of nuclear shielding (the property giving rise to the chemical shift) including full tensor calculations and isotope shifts, followed by applications of nuclear shielding, covering comprehensively all of the various nuclides that give rise to NMR spectra. Similarly the next two chapters cover theoretical aspects of spin-spin couplings (by this is meant only the indirect or J-coupling, although there is a short section on residual dipolar couplings as seen in oriented samples), again covering a wide range of nuclear pairs and also anisotropy in the J tensor, followed by applications of spin-spin couplings for many pairs of nuclides, listing interactions over one, two, three and more bonds, plus through-space effects and couplings across hydrogen bonds. One section lists new pulse methods for obtaining J-coupling values. Next comes an excellent critical review chapter on nuclear spin relaxation in liquids and gases covering theory, experimental methods and selected applications. This is followed by a chapter on solid state NMR spectroscopy, describing new experimental methods, determination of NMR parameters for both spin one-half and quadruple nuclei, and applications ranging over organic and inorganic systems, amino acids, peptides and proteins, biomedical and pharmaceutical systems, coals, polymers, glasses, porous solids and surfaces. There are also subsequent chapters on applications of NMR spectroscopy to proteins and nucleic acids, carbohydrates, lipids and membranes, synthetic macromolecules, liquid crystals and micellar solutions and finally NMR in Jiving systems, including new methodologies. The fields chosen are all very active, ranging over physical, organic, analytical and biological chemistry, with much research being undertaken across the world. The coverage of the literature has resulted in thousands of citations just in these selected fields, with several chapters providing over 400 references. Whilst the book provides a comprehensive compilation of the literature over the designated 12-month period (with one chapter covering 24 months from June 2008), in general there is not a great deal of critical review of the papers cited and of course by the time the book is published even the latest references are already more than a year old. Nevertheless, the volume proves a useful snapshot of the work done in a particular field and thus it is a helpful entry into the literature from which more information could be obtained. Given the diverse subject matter of the various chapters, most scientists would probably be interested in only one chapter. This reference work is produced to a high quality but in this age of online literature searching and electronic journals, it is unlikely that this volume will be bought by many individuals, and it is suspected that institutional libraries will be the chief purchasers. -- John C. Lindon * Chromatographia (2012) 75:559-560 DOl 10. 1007/s 10337-012-2209-5 *Table of ContentsPreface; Books and reviews; Theoretical and physical asepcts of nuclear shielding; Applications of nuclear shielding; Theoretical aspects of spin-spin couplings; Applications of spin-spin couplings; Nuclear spin relaxation in liquids and gases; Solid-state NMR spectroscopy; NMR of proteins and nucleic acids; NMR of carbohydrates, lipids and membranes; Synthetic macromolecules; NMR of liquid crystals and micellar solutions; NMR in living systems

Read more less

Book SynopsisThe Clermont-Ferrand-Theix Institut National de la Recherche Agronomique (INRA) was proud to organize the 10th International Conference on the applications of Magnetic Resonance in Food Science to celebrate its 10th anniversary. This scientific event was held from 13 to 15 September 2010 in Clermont-Ferrand. The conference attracted 90 participants from 14 countries from all over the world. The conference included 7 invited lectures, 19 oral presentations and 27 oral poster presentations. Moreover, before the scientific sessions, two postgraduate sessions were given in parallel every morning. The conference was divided in 6 sessions covering i) Data processing, ii)New developments/food system, iii) New developments/NMR, iv) Nutrition, v) Metabolomic and vi) Imaging. The book follows the form of the conference. This year's meeting corresponded to its 10th anniversary. The first international conference was held in 1992 at the University of Surrey in Guilford on Professor Peter Belton's and Professor Graham Webb's initiative. During the last 20 years, a lot of developments were performed and the next 20 years are also very exciting. This meeting presentations were focused on the new developments in NMR techniques: hardware as well software with metabolomic and imaging without the new applications of NMR tools in food of course and now in nutrition.Table of ContentsData processing; New developments/food system; New developments/NMR; Nutrition; Metabolomic and imaging.

Read more less

Book SynopsisAs a spectroscopic method, nuclear magnetic resonance (NMR) has seen spectacular growth, both as a technique and in its applications. Today's applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive coverage of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules, which is covered in two reports: NMR of Proteins and Nucleic Acids and NMR of Carbohydrates, Lipids and Membranes. In his foreword to the first volume, the then editor, Professor Robin Harris announced that the series would be a discussion on the phenomena of NMR and that articles will be critical surveys of the literature. This has certainly remained the case throughout the series, and in line with its predecessors, Volume 40 aims to provide a comprehensive coverage of the relevant NMR literature. For the current volume this relates to publications appearing between June 2009 and May 2010 (the nominal period of coverage in volume 1 was July 1970 to June 1971). Compared to the previous volume there are some new members of the reporting team. Theoretical Aspects of Spin-Spin Couplings are covered by J. Jazwinski, while E. Swiezewska and J.Wojcik provide an account of NMR of Carbohydrates, Lipids and Membranes.Table of ContentsPreface; NMR Books and Reviews; Theoretical and Physical Aspects of Nuclear Shielding; Theoretical Aspects of Spin-Spin Couplings; Applications of Spin-Spin Couplings; Solid-State NMR Spectroscopy; NMR of Carbohydrates, Lipids and Membranes; Nuclear Spin Relaxation in Liquids and Gases; Synthetic Macromolecules; Oriented Molecules; NMR of Proteins and Nucleic Acids

Read more less