Immunology Books
Springer Us Genetics of the Immune Response 55 Nobel Foundation Symposia
Book SynopsisThe 55th Nobel Symposium entitled "Genetics of the Immune Response" took place in Saltsjobaden, Sweden, June 15 - 17, 1982. The symposium was sponsored by the Nobel Foundation and its Nobel Symposium Committee through grants from the Tercentenary Fund of the Bank of Sweden and the Knut & Alice Wallenberg Foundation.Table of ContentsSession I: Antibody V Genes.- The Formation of Antibody Variable Region Genes.- Discussion.- Session II: Antibody C Genes.- Organization and Reorganization of Constant Region Genes of Immunoglobulin Heavy Chains: Genetic Basis for Class Switching.- Discussion.- Session III: MHC Genes.- Molecular Analysis of MHC Antigens.- Discussion.- Session IV: MHC Antigens and T Cell Function.- Immunological Surveillance: T Cell Repertoire and the Biological Function of MHC Antigen.- Discussion.- Session V: Induction and Effector Functions of T Cells.- Induction and Effector Function of T Cells.- Discussion.- Session VI: T Cell Regulation.- T-Cell Growth Factor, A Lymphocytotropic Hormone.- Discussion.- Session VII: B Cell Differentiation.- Stimulation of a B Cell Subset by Anti-Immunoglobulin and T Cell-Derived Regulatory Molecules.- Discussion.- Session VIII: B Cell Regulation I.- The Degree of Clonal Elimination in Immunological Tolerance and Regulation of Heavy Chain Class.- Discussion.- Session IX: B Cell Regulation II.- Factors Determining Virgin and Postantigenic Repertoires of B Cell Population and Its Subsets.- Discussion.- Session X: Immune Networks.- Is the Network Theory Tautologic?.- Discussion.- List of Participants.
£42.74
Chicago Review Press Wits Guts Grit: All-Natural Biohacks for Raising
Book SynopsisWits Guts Grit is inspired by the many questions acclaimed science writer and mother Jena Pincott explored about the natural forces that shape children’s minds and health. What if we identify the microbes that support stress resilience and find ways to expose our kids to them? What if we reintroduce the mineral magnesium, deficient in almost every child’s diet? Would it reduce anxiety and increase bounce back, as the science now suggests? What if memory and learning could improve measurably after eating certain foods—such as blueberries—high in plant chemicals called flavonols, or after certain forms of exercise? These and many more questions led Pincott to simple, all-natural “biohacks”—experiments inspired by current research and theory—complete with instructions on how to undertake them to help your own children strengthen their wits, guts, and grit. Explaining the science and her own experimentation with her two gung-ho daughters in a lively, accessible way, Pincott shows parents how the underlying ingredients of the traits we all want for our kids—resilience, focus, perseverance, working memory, and more—may be all around us in the natural world, ready to be harnessed.Trade Review"The brilliant Jena Pincott has done it again with Wits Guts Grit . A must read for every parent, teacher, psychologist, social worker, pediatrician and childcare provider. Five Stars." Louann Brizendine MD, neuropsychiatrist and author of the New York Times bestsellers The Female Brain and The Male Brain"If you are the kind of parent who reads the latest studies on resilience and achievement and wonder how they might really apply to your own kids, Jena Pincott's Wits Guts Grit is the book for you. Pincott breaks down the science in an entertaining and accessible wayand then offers a series of remarkable step-by-step "biohacks," or at-home experiments, to show parents how they can use the very world around them to help guide their kids grow into the most resilient, focused, and thoughtful version of themselves." Kayt Sukel, author of The Art of Risk: The New Science of Courage, Caution & Chance and This is Your Brain on Sex"Jena Pincott is a science writer who doesn't just ask questions and search for answers, she also applies the best of what she learns in her life. This book is the result of an evident passion for sharing her applied knowledge, and it will no doubt influence many lives for the better. It's a fantastic example of what I call 'science-help' in its truest form." David DiSalvo, author of What Makes Your Brain Happy and Why You Should Do the Opposite" Wits Guts Grit will be a sought-after addition for any public library parenting collection." Booklist"Accessibly informative, with thoughtful and thought-provoking observational commentary, Wits Guts Grit: All-Natural Biohacks for Raising Smart, Resilient Kids is fully and unreservedly recommended for both community and academic library Parenting instructional reference collections and supplemental studies lists." Midwest Book Review
£12.71
Scribe Publications Immune: stay healthy and take good care of your
Book SynopsisLearn how to strengthen your immune system, for life. Our immune system is our body’s fortress — without it, we would be vulnerable to all sorts of infections and diseases. Yet misinformation about how to boost the immune system is everywhere. In Immune, Dr Servaas Bingé breaks through those myths, translating the latest scientific findings on immunity into clear advice with which you can optimise your lifestyle. Using no-nonsense language with a touch of humour and lots of creative thinking, Bingé takes us on a fascinating journey through our immune system. He explains how we become ill and how best to protect against it, providing superb guidance for the most important thing you can do — stay healthy.
£11.04
Springer Epigenetics and Rare Diseases
Book SynopsisPreface.- 1. From Genetics to Epigenetics: The Steps of a Path.- 2. Molecular basis of epigenetic mechanisms.- 3. Epigenetics and Endocrine Disruptors.- 4. New insights into the fetal programming hypothesis of the linkage between neurodevelopmental disorders and impaired neurogenesis.- 5. The Placenta and the development of human health.- 6. Epigenetics and cancer.- 7. Epigenetics in Autoimmune Diseases.- 8. Epigenetics and Systemic Vasculitis.- 9. Epigenetics and Allergic Diseases.- 10. The Role of Epigenetics in Autoinflammatory Diseases.- 11. Epigenetics and immune-mediated diseases.- 12. Epigenetics and Inherited Metabolic Disorders.- 13. Epigenetics and Psychiatric Diseases.- 14. The metabolomics revolution toward personalized medicine: the case of gestational diabetes.- 15. Epigenetics and Microbiome.- Index.
£98.99
Urban & Fischer/Elsevier BASICS Immunologie
Book Synopsis
£24.30
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Lunge und Atemwege
Book SynopsisDer Band aus der Reihe „Module Innere Medizin“ ermöglicht Lernenden den Blick aufs Ganze. Systematisch stellen die Autoren das gesamte Organsystem Lunge und Atemwege dar: von der Anatomie über die Physiologie bis zur Diagnostik und Therapie von Erkrankungen. Wegen seiner Praxisnähe eignet sich der Band nicht nur für Studierende, sondern auch für Ärzte in der pneumologischen Aus- und Weiterbildung.Trade Review“... Das Buch lohnt sich vor allem für den klinischen Abschnitt. Der Text ist gut verständlich geschrieben udn wird ergänzt durch zahlreiche anatomische Zeichnungen, Röntgen- und CT-Bilder und ähnlichen. Die Gliederung ist klar und fasst die wichtigsten Erkrankungen gut zusammen.” (in: AirMediPlus, Heft 4, 2015)“... Es ist kurz und praktisch zusammengefasst und man kann sich in kurzer Zeit einen guten Überblick verschaffen. ... Diagnostische Methoden werden sehr gut beschrieben und auch mit vielen Bildern verständlich gemacht. Die in Farbe hervorgehobenen Kästchen mit wichtigen Informationen sind sehr hilfreich und nicht zu häufig. Alles in allem wird man mit diesem Kurzlehrbuch gut für den Klinikalltag vorbereitet und kann damit auch die dazugehörigen Prüfungen bewältigen ...” (in: Fachschaft Medizin LMU München, fachschaft-medizin.de, Dezember 2015)“ ... ist das Buch wirklich sehr übersichtlich gegliedert und angenehm zu lesen ... Als Basic-Lehrbuch ist dieses Werk wirklich toll um sich kurz und bündig in das gesamte Spektrum der Pneumologie einzulesen und gut vorbereitet in die Famulatur oder ins KPJ zu starten ...” (Bösch, Dennis, in: Medizinische Universität Innsbruck, skalpell.at, 11. März 2015)"... sehr übersichtlich gegliedert und angenehm zu lesen. ... Als Basic-Lehrbuch ist dieses Werk wirklich toll um sich kurz und bündig in das gesamte Spektrum der Pneumologie einzulesen ..." (Katharina Greber, in: Der Medicus, Heft 1, 2015)“… gibt es viele anatomische Zeichnungen, die z.B. bei der Auskultation die Punkte zeigen, auf denen das Stethoskop aufgelegt werden sollte, um optimal abhören zu können. Also gibt es viele Röntgen- und CT-Bilder, welche schließlich zur Basisdiagnostik von Lungenerkrankungen gehören (neben der Anamnese und körperlichen Untersuchung) ...“ (in: Fachschaft Medizin Münster, fsmed-muenster.de, 2. Januar 2015)“... Das Buch ist laut Vorwort speziell für Medizinstudenten und junge Assistenten in Weiterbildung verfasst, jedoch auch Kollegen in Weiterbildung zu verschiedenen Facharzt- oder Spezialtiteln und erfahrene Fachärzte dürfen sich jederzeit eines Repetitoriums erfreuen, denn auch das kann das Buch bieten. ... Mit zahlreichen Tabellen, Graphiken und Abbildungen aus der Klinik wird man durch das Buch geführt. ... Der Lehrtext lässt sich flüssig lesen und ist verständlich nachzuvollziehen ...“ (Veronika Gebhardt, in: webcritics.de, 15. Januar 2015)“... übersichtlich gegliedert, mit Grafiken, Tabellen und Infoboxen ansprechend gestaltet und schön illustriert. ... Das Buch vermittelt zunächst alle grundlegenden Informationen zur Anatomie und Physiologie der Lunge, um diese wieder in Erinnerung zu rufen. ... Ätiologie und Pathophysiologie erklärt werden und zu denen jeweils die Diagnostik – gut illustriert - und die Therapie vorgestellt werden. ... als tolles Lehrbuch, das dieses Thema vor allem gut verständlich und sehr übersichtlich vermittelt ...“ (in: Veasyte, Wintersemester/2014-2015, S. 60 f.) “... Der Text ist gut verständlich geschrieben und wird ergänzt durch zahlreiche anatomische Zeichnungen,Schemata, Röntgen- und CT-Bilder und ähnlichen. Die Gliederung ist klar und fasst die wichtigesten Erkrankungen gut zusammen. Wichtige Inhalte sind nochmal in farbigen Abschnitten zusammengefasst oder in Tabellen wiedergegeben ...“ (in: FiMM Fachschaftsinitiative Medizin Mannheim FiMM-online.de, September 2014)“... Das Buch lohnt sich vor allem für den klinischen Abschnitt ... Der Text ist gut verständlich geschreiben[sic] und wird ergänzt durch zahlreiche anatomische Zeichnungen, Röntgen- und CT-Bilder und ähnlichen. Die Gliederung ist klar und fasst die wichtigesten Erkrankungen gut zusammen. ...wer schonmal unterwegs lernt (in Zug oder Stadtpark) und nicht immer das dicke Standardwerk Innere Medizin mit sich schleppen möchte, für den ist dieses Buch eine gute Alternative.“ (JohannaBS, in: Amazon.de, 15. September 2014)Table of Contents1. Anatomie und Physiologie der Lunge und Atemwege.- 2. Pneumologische Diagnostik.- 3. Epidemiologie pneumologischer Ekrankungen - Prävalenz, Risikofaktoren und Prävention.- 4. Obstruktive Atemwegs- und Lungenerkrankungen.- 5. Infektiöse Atemwegs- und Lungenerkrankungen.- 6. Diffuse Lungenparenchymerkrankungen.- 7. Lungengefäßerkrankungen.- 8.Lungen- und Bronchialtumoren.- 9. Pleuraerkrankungen.- 10. Atmungsstörungen und Atemregulationsstörungen.- 11. Tabakentwöhnung.
£32.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Intracellular Antibodies: Development and Applications
Book SynopsisRecent advances in the field of recombinant antibodies have permitted the manipulation of genes encoding specific antibodies, thus allowing their ectopic expression in a wide variety of non-lymphoid cells. This volume describes how the ectopic expression of antibodies, as secreted or as intracellularly retargeted molecules, can be exploited to block biological functions or to confer new phenotypic traits (e.g. resistance to a virus). This is the first book describing this emerging technology, which is receiving increasing attention for application in many different fields and biological systems - from human gene therapy to plant biotechnology.Table of Contents1. Intracellular and Intercellular Immunization.- 2. Current Methods for Genotypic and Phenotypic Knock-Outs in Mammalian Cells.- 3. Recombinant Antibodies for Ectopic Expression.- 4. Assembly and Folding of Antibodies in Natural and Artificial Environments.- 5. Protein Sequence Motifs Involved in Intracellular Trafficking.- 6. Intercellular Immunization.- 7. Intracellular Immunization.- 8. Gene Therapy and Research Applications of Intrabodies for Human Infectious Diseases.- 9. Plantibodies: Immunomodulation and Immunotherapeutic Potential.- 10. From Phage Libraries to Intracellular Immunization.- 11. Perspectives and Conclusions.
£42.74
Taylor & Francis Ltd Molecular Genetics of Drug Resistance
Book SynopsisDrug resistance is a growing problem in today's society. Successful drugs are constantly being developed but there is always the risk that a small percent of the drug's target will be immune. These survivors can then lead to a new population, resistant to the action of this drug. New drugs are continuously under development to combat this problem, but these can, in turn, lead to new resistant populations. This problem is universal whether the target is to destroy a deadly virus, or an insect which is ravaging crop production. Development of new drugs is difficult and time consuming so it is of crucial importance that we understand the processes behind drug resistance. "Molecular Genetics of Drug Resistance" forms a vital and timely review of the genetic processes behind drug resistance. Starting with an overview of the area, each chapter focuses on a particular target with important sections on drug resistance in malaria and in cancer. Each chapter has been written by an acknowledged expert in the field and the careful work of the editors has ensured a consistent approach and presentation. Table of ContentsNatural selection and drug resistance; drug and pesticide resistance in fungi; viral drug resistance; herbicide resistance; drug resistance in insects; the mechanisms of drug action and resistance in malaria; multidrug resistance in mammalian cells mediated by members of the ATP-binding cassette superfamily; drug resistance in cancer chemotherapy; oxidative stress responses in mammalian cells; modulation and circumvention of drug resistance.
£210.00
Intechopen Systemic Sclerosis
£89.25
Pan Stanford Publishing Pte Ltd Immune Aspects of Biopharmaceuticals and
Book SynopsisThe enormous advances in the immunologic aspects of biotherapeutics and nanomedicines in the past two decades has necessitated an authoritative and comprehensive reference source that can be relied upon by immunologists, biomedical researchers, clinicians, pharmaceutical companies, regulators, venture capitalists, and policy makers alike. This text provides a thorough understanding of immunology, therapeutic potential, clinical applications, adverse reactions, and approaches to overcoming immunotoxicity of biotherapeutics and nanomedicines. It also tackles critical, yet often overlooked topics such as immune aspects of nano-bio interactions, current FDA regulatory guidances, complement activation-related pseudoallergy (CARPA), advances in nanovaccines, and immunogenicity testing of protein therapeutics. Trade Review"This outstanding volume represents a review of the various effects of biopharmaceuticals and nanomedicines on the immune system: immunotherapy, vaccines, and drug delivery; challenges and overcoming translational barriers stemming from immunotoxicity; strategies to designing more immunologically friendly formulations." —África González-Fernández, PhD, MD, Professor of Immunology and President of the Spanish Society of Immunology, University of Vigo, Spain "For those who are specialists, and for those interested in a broader understanding of biologics and nanomedicines, this is a superb book, with internationally accomplished contributors. It serves both as a reference and as a practical guide to the newest advances in these important fields. Highly recommended!"—Carl R. Alving, MD, Emeritus Senior Scientist, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA "A skillfully produced book that addresses an often-missed topic: immune aspects of biologicals and nanoscale therapeutics, with an emphasis on clinical relevance and applications." —Rajiv R. Mohan, PhD, Professor and Ruth M. Kraeuchi Missouri Endowed Chair Professor, University of Missouri, Columbia, USA"An indispensable masterpiece! It represents a rich source of information on interactions of biologics and nanodrugs with the immune system—all critical for medical applications. Volume 3, once again, achieves the series’ high standards."—László Rosivall, MD, PhD, DSc Med, Med habil., Széchenyi Prize Laureate and Professor, Faculty of Medicine, Semmelweis University, Budapest, Hungary "Hats off to Dr. Bawa for producing yet another impressive volume in terms of scope, timeliness, and relevance. With expert contributions from around the globe, this book addresses topics germane to researchers, clinicians, drug and biotherapeutic companies, regulators, policymakers, and patients." —Sara Brenner, MD, MPH, Associate Professor and Assistant Vice President, SUNY Polytechnic Institute, Albany, New York, USA"Marvelous! This timely book shows clearly that while an immune reaction to "nano-exposure" is usually unwanted, the same response also bears an immense potential." —Silke Krol, PhD, IRCCS Istituto Tumori "Giovanni Paolo II" and Fondazione IRCCS Istituto Neurologico "Carlo Besta," ItalyThe enormous advances in the immunologic aspects of biotherapeutics and nanomedicines in the past two decades has necessitated an authoritative and comprehensive reference source that can be relied upon by immunologists, biomedical researchers, clinicians, pharmaceutical companies, regulators, venture capitalists, and policy makers alike. This text provides a thorough understanding of immunology, therapeutic potential, clinical applications, adverse reactions, and approaches to overcoming immunotoxicity of biotherapeutics and nanomedicines. It also tackles critical, yet often overlooked topics such as immune aspects of nano-bio interactions, current FDA regulatory guidances, complement activation-related pseudoallergy (CARPA), advances in nanovaccines, and immunogenicity testing of protein therapeutics. Table of ContentsList of Corresponding Authors, Foreword, My Life with Biologicals and Nanodrugs: A Twenty-Year Affair, 1. Current Immune Aspects of Biologics and Nanodrugs: An Overview, 2. Immunological Issues with Medicines of Nano Size: The Price of Dimension Paradox, 3. Immunotherapy and Vaccines, 4. Site-Specific Antibody Conjugation for ADC and Beyond, 5. Current Understanding of Interactions between Nanoparticles and the Immune System, 6. Auto-antibodies as Biomarkers for Disease Diagnosis, 7. The Acceleated Blood Clearance Phenomenon of PEGylated Nanocarriers, 8. Anti-PEG Immunity Against PEGylated Therapeutics, 9. Complement Activation: Challenges to Nanomedicine Development, 10. Intravenous Immunoglobulin at the Borderline of Nanomedicines and Biologicals: Antithrombogenic Effect via Complement Attenuation, 11. Lessons Learned from the Porcine CARPA Model: Constant and Variable Responses to Different Nanomedicines and Administration Protocols, 12. Blood Cell Changes in Complement Activation-Related Pseudoallergy: Intertwining of Cellular and Humoral Interactions, 13. Rodent Models of Complement Activation-Related Pseudoallergy: Inducers, Symptoms, Inhibitors and Reaction Mechanisms, 14. Immune Reactions in the Delivery of RNA Interference-Based Therapeutics: Mechanisms and Opportunities, 15. Lipid Nanoparticle Induced Immunomodulatory Effects of siRNA, 16. Nanovaccines against Intracellular Pathogens Using Coxiella burnetii as a Model Organism, 17. Immunogenicity Assessment for Therapeutic Protein Products, 18. Assay Development and Validation for Immunogenicity Testing of Therapeutic Protein Products, 19. The “Sentinel”: A Conceptual Nanomedical Strategy for the Enhancement of the Human Immune System, 20. Immunotherapy for Gliomas and Other Intracranial Malignancies, 21. Engineering Nanoparticles to Overcome Barriers to Immunotherapy, 22. Metal-Based Nanoparticles and theImmune System: Activation, Inflammation, and Potential Applications, 23. Silica Nanoparticles Effects on Hemostasis, 24. Valproate-Induced Rodent Model of Autism Spectrum Disorder: Immunogenic Effects and Role of Microglia, 25. Accelerated Blood Clearance Phenomenon and Complement Activation-Related Pseudoallergy: Two Sides of the Same Coin, 26. Current and Rising Concepts in Immunotherapy: Biopharmaceuticals versus Nanomedicines, 27. Characterization of the Interaction between Nanomedicines and Biological Components: In vitro Evaluation, 28. Unwanted Immunogenicity: From Risk Assessment to Risk Management, 29. Emerging Therapeutic Potential of Nanoparticles in Pancreatic Cancer: A Systematic Review of Clinical Trials, 30. SGT-53: A Novel Nanomedicine Capable of Augmenting Cancer Immunotherapy, Index
£346.50
John Wiley and Sons Ltd Vaccinology
Book SynopsisVaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines.Trade Review“It can also serve as a useful reference for practicing physicians and veterinarians who would like to “boost” their knowledge of vaccines.” (Clinical Infectious Diseases, 6 October 2015)Table of ContentsContributors vii Preface ix 1 The history of vaccine development and the diseases vaccines prevent 1Martin G. Myers 2 The vaccine development pathway 33David W.C. Beasley 3 Control and eradication of human and animal diseases by vaccination 43Nigel Bourne and Gregg N. Milligan 4 Pathogenesis of infectious diseases and mechanisms of immunity 59Jere W. McBride and David H. Walker 5 The host immune response protective immunity and correlates of protection 73Gregg N. Milligan 6 Adjuvants: making vaccines immunogenic 93Gregg N. Milligan 7 Discovery and the basic science phase of vaccine development 109Gavin C. Bowick 8 Microbial-based and material-based vaccine delivery systems 127Alfredo G. Torres, Jai S. Rudra and Gregg N. Milligan 9 Licensed vaccines for humans 152Alan D.T. Barrett 10 Veterinary vaccines 181A. Paige Adams 11 Development of vaccines for microbial diseases 192Dennis W. Trent and David W.C. Beasley 12 The regulatory path to vaccine licensure 212Dennis W. Trent 13 Veterinary vaccines: regulations and impact on emerging infectious diseases 232A. Paige Adams 14 Vaccine manufacturing 243Dirk E. Teuwen and Alan D.T. Barrett 15 Clinical evaluation of vaccines 260Richard E. Rupp and Bridget E. Hawkins 16 Vaccine recommendations and special populations 273Richard E. Rupp and Bridget E. Hawkins 17 Vaccine safety 287Dirk E. Teuwen and Alan D.T. Barrett 18 Understanding and measuring the dynamics of infectious disease transmission 304Christine M. Arcari 19 Vaccines from a global perspective 319Alan D.T. Barrett and Bridget E. Hawkins 20 Political ethical social and psychological aspects of vaccinology 335Caroline M. Poland, Robert M. Jacobson, Douglas J. Opel, Edgar K. Marcuse and Gregory A. Poland Index 358
£80.96
John Wiley and Sons Ltd Transplant Immunology
Book SynopsisWith all the complex issues of acceptance or rejection of a transplanted organ, immunology is a key subject for all transplantation clinicians. During recent years, there has been an explosion of research and knowledge in this area.Table of ContentsContributors, vii Foreword, xii Preface, xiv About the companion website, xv 1 Tissues and organs of the immune system, 1Isam W. Nasr, Qiang Zeng, and Fadi G. Lakkis 2 Cells of the immune system, 25Jason R. Lees, Agnes M. Azimzadeh, Yaozhong Ding, Tonya J. Webb, and Jonathan S. Bromberg 3 Soluble mediators in the immune system, 48Charles A. Su, William M. Baldwin III, and Robert L. Fairchild 4 Costimulatory molecules, 65Maria]Luisa Alegre and Anita S. Chong 5 Major histocompatibility complex, 85Raja Rajalingam, Qiuheng Zhang, J. Michael Cecka, and Elaine F. Reed 6 T cells and the principles of immune responses, 103Jonathan S. Maltzman, Angus Thomson, and David M. Rothstein 7 Ischemia and reperfusion injury, 128Yuan Zhai, Yoichiro Uchida, Bibo Ke, Haofeng Ji, and Jerzy W. Kupiec]Weglinski 8 Immune responses to transplants, 142Denise J. Lo and Allan D. Kirk 9 Principles of hematopoietic cell transplantation, 164Sung Choi and Pavan Reddy 10 Therapeutic approaches to organ transplantation, 184Philip F. Halloran, Chatchai Kreepala, Gunilla Einecke, Alexandre Loupy, and Joana Sellarés 11 Organ]specific features in clinical transplantation, 217Roslyn B. Mannon 12 Transplant]related complications, 237Leonardo V. Riella and Anil Chandraker 13 Biomarkers of allograft rejection and tolerance, 259Choli Hartono, Thangamani Muthukumar, and Manikkam Suthanthiran 14 Emerging issues in transplantation, 280Rupert Oberhuber, Guangxiang Liu, Timm Heinbokel, and Stefan G. Tullius 15 New frontiers and new technologies, 297Haval Shirwan, Yiming Huang, Kadiyala Ravindra, and Suzanne T. Ildstad 16 Experimental models in discovery and translational studies, 316Andrew B. Adams, William H. Kitchens, and Kenneth A. Newell Index, 337
£62.96
John Wiley & Sons Inc Gastroenteritis Viruses No 238 Novartis
Book SynopsisThis important book covers the structure and molecular biology of small round structured viruses (SSRVs) such as caliciviruses and astroviruses, and the basic pathology of infection. It provides readers with the knowledge needed to make progress in the prevention and treatment of these infections.Table of ContentsIntroduction (M. Estes). Gastroenteritis Viruses: An Overview (R. Glass, et al.). Structural Studies on Gastroenteritis Viruses (B. Prasad, et al.). Early Events of Rotavirus Infection: The Search for the Receptor(s) (C. Arias, et al.). Rotavirus RNA Replication and Gene Expression (J. Patton). Pathogenesis of Rotavirus Gastroenteritis (M. Estes, et al.). Correlates of Protection Against Rotavirus Infection and Disease (P. Offit). Rotavirus Epidemiology and Surveillance (U. Desselberger, et al.). A Rotavirus Vaccine for Prevention of Severe Diarrhoea of Infants and Young Children: Development, Utilization and Withdrawal (A. Kapikian). The Molecular Biology of Human Caliciviruses (I. Clarke & P. Lambden). Molecular Epidemiology of Human Enteric Caliciviruses in The Netherlands (M. Koopmans, et al.). Molecular Biology of Astroviruses: Selected Highlights (S. Matsui, et al.). Molecular Epidemiology of Human Astroviruses (S. Monroe, et al.). Enteric Infections with Coronaviruses and Toroviruses (K. Holmes). Viruses Causing Diarrhoea in AIDS (R. Pollok). Treatment of Gestrointestinal Viruses (M. Farthing). Summing-Up (M. Estes). Index of Contributors. Subject Index.
£89.06
John Wiley & Sons Inc Applications of Fluorescence in Immunoassays
Book SynopsisDescribes the basic prerequisities for a fluorometric immunoassay: the antibody, the immunological technology, the fluorescent probe, and the instrument. Provides a profile of the clinical applications of the various assay technologies.Table of ContentsAntibodies as Analytical Reagents. Evolution of Immunoassays. Non-Isotopic Immunoassays. Photoluminescence Spectroscopy. Instruments in Fluorometric Immunoassays. Photoluminescent Probes. Fluorescence Immunoassays. Fluorometric Enzyme Immunoassays. Other Specific Binding Assays Using Fluorescence. Multiparametric Immunoassays. References. Index.
£268.15
John Wiley & Sons Inc Immunology A Foundation Text
Book SynopsisThis book provides an integrated approach to the study of immunology for people who seek a user-friendly', concise and up-to-date foundation text. There can be few subjects that so obviously demand such an approach. Immunology overlaps with the biological disciplines of biochemistry, cell biology, genetics, physiology, microbiology and parasitology relying on methods and concepts derived from these disciplines, and in turn contributing to them. After describing the components of the immune system, and explaining how they interact, the author goes on to discuss the many important applications of immunology in laboratory techniques and in medicine. In addition to this introductory' material, the book considers new, and likely future developments giving the reader a taste of the rapid rate of progress in this important field. The author's clear and concise text is supported by a wealth of illustrations (most in two-colour), self-assessment questions and a comprehensive index making thiTable of ContentsImmunity to Infection. Innate Immunity. The Cells of Adaptive Immunity. The Molecules of Adaptive Immunity. Collaboration and Escape. Antigens. Applications of Antigen Recognition. Maturation of the Adaptive Response. Regulation of the Immune Response. Disorders of Immunity. Self Assessment Questions (SAQs). Answers to SAQs. Optional Further Reading. Index. Acknowledgements.
£160.16
John Wiley & Sons Inc Immunology
Book SynopsisHow good a representative is the immune system of a laboratory mouse? How may technical obstacles in one immunological model be bypassed by using another? How much progress has been made in the study of defense mechanisms in plants and animals of commercial importance? The answers to these and numerous other questions regarding the immunological similarities which can be detected across various orders, classes, phyla and kingdoms are found in this book. Provides pertinent information on the advances, opportunities and challenges in comparative work.Table of ContentsPlants (J. Metraux). Invertebrates (D. Millar & N. Ratcliffe). Fishes (M. Manning). Amphibians (J. Horton). Reptiles and Birds (R. Jurd). Mammals (R. Turner). Index.
£166.46
University of California Press State of Immunity
Book SynopsisA comprehensive history of the social and political aspects of vaccination in the United States, this work tells the story of how vaccination became a widely accepted public health measure over the course of the twentieth century. It examines the strategies that health officials have used to gain public acceptance of vaccines.Table of ContentsList of Illustrations Foreword by Daniel M. Fox Acknowledgments Introduction: Vaccination Politics and Law in American History 1. Between Persuasion and Compulsion: Vaccination at the Turn of the Twentieth Century 2. Science in a Democracy: Smallpox Vaccination in the Progressive Era and the 1920s 3. Diphtheria Immunization: The Power, and the Limits, of Persuasion 4. Hard Cores and Soft Spots: Selling the Polio Vaccine 5. Eradicationism and Its Discontents 6. Consent, Compulsion, and Compensation: Vaccination Programs in Crisis 7. Expansion and Backlash: Vaccination at the Turn of the Twenty-First Century Notes Archival Sources Index
£56.80
Harvard University Press The Generation of Diversity
Book SynopsisThis book is an intellectual history of the major theoretical problem in immunology and its resolution in the postâWorld War II period. In recent years immunology has been one of the most excitingâand successfulâfields of biomedical research; this book provides essential background for understanding the conceptual conflicts occurring in the field.Trade ReviewScott Podolsky and Alfred Tauber have written a dense and exhaustive scholarly treatise about the history of [the generation of diversity]. They explore the intellectual setting in which the Tonegawa experiment was performed by reviewing original literature and interviewing the major actors in the drama...Everyone interested in the history of immunology and genetics should read this book. -- Fred S. Rosen * Nature *The Generation of Diversity is a remarkable mixture of formal history, literature review, and 'immunophilosophy.' It traces the origins of Burnet's clonal selection theory as a central paradigm of contemporary immunology, then reconciles that theory with the discoveries of the molecular era, and concludes with consideration of 'the immune self'...The authors' meticulously detailed background to the experimental work is a tour de force, which one would never expect to be attempted again, and it stands as a vibrant testament to an extraordinary era for immunology. -- Ian R. Mackay * Science *This book is thoroughly researched, well written, and obviously intended to be definitive with respect to clonal selection and the generation of antibody diversity… Despite, or perhaps because of, the great amount of detail in this book, I enjoyed reading it… For an immunologist, it is satisfying to have the history of two major areas of research recapitulated. This book includes many details I missed earlier or had forgotten, and it is of interest to compare the authors’ assignment of priorities for correct conclusions with those of the principals, as expresses in their own reviews of the topic. This book will be an essential part of the collection of anyone with an interest in the history of immunology. -- Alfred Nisonoff * New England Journal of Medicine *This scholarly historiography is a must for those with more than a passing interest in immunology. Nine well-structured chapters cover the issues that have led to a general acceptance of the clonal selection theory and the establishment of molecular immunology as the arbiter of current thinking… Scott Podolsky and Alfred Tauber’s conceptual grasp of the ideas is anchored by a thorough explanation of critical experiments. They bring an almost extravagant degree of research, and attention to every argument, rendering the finished product as readable as a good novel. -- Richard Lake * Times Higher Education Supplement *Several recent studies have shown the central role of techniques, instruments, reagents and experimental systems in the ‘molecularization of biology and medicine’, first by focusing on the structure of proteins, then on the structure of nucleic acids (DNA and RNA). The Generation of Diversity is a fascinating account of how exactly this change took place in immunology. The book’s main strength [is] telling a very detailed story of a transformation of a single domain of scientific inquiry. -- Ilana Löwy * Medical History [UK] *A balanced and lucid conceptual history of postwar immunology, documenting one of its most fundamental transformations. This is an important and original contribution to the history of twentieth century biology. -- Angela Creager, Princeton UniversityTable of ContentsA conceptual orientation; the Burnet legacy; CST and molecular immunology - a dogmatic alliance; interlude - the conventional history; germline, somatic mutation and recombinatorial models - 1960-1974; immunobiological theories of antibody diversity; from protein to DNA; the recombinant revolution; interlude - a historigraphic reappraisal; heavy chain diversity and the molecular finale; an accounting; the fate of the immune self.
£37.36
Johns Hopkins University Press When the Diagnosis Is Multiple Sclerosis Help
Book SynopsisThis medically up-to-date and compassionate book offers guidance not only to patients and their families but to healthcare professionals, psychologists, psychiatrists, and physical and occupational therapists.Trade ReviewDr. Furney draws on her own experience and medical expertise to show that life can be lived to the fullest with MS. She covers psychological challenges, having children, handling a career, and staying healthy-all in a readable-over-a-cup-of-coffee kind of way. Unfailingly honest, Dr. Furney shows a very human aspect of the doctor-patient relationship. Momentum Magazine This is an excellent addition to the MS literature, offering hope to patients and helping to educate healthcare professionals about what it is really like being on the other side of the physician-patient encounter. -- Joseph I. Sirven Doody's Review Service 2009Table of ContentsSeries ForewordPrefaceAcknowledgments Chapter 1. Being DiagnosedChapter 2. GrievingChapter 3. The Psychological Challenges of MSChapter 4. Facing the Needle: The MS MedicationsChapter 5. Whom Do I Tell and When?Chapter 6. Impact on Our JobsChapter 7. Having ChildrenChapter 8. Staying Healthy and FitChapter 9. Managing the Fatigue of Multiple SclerosisChapter 10. Could I Be Depressed?Chapter 11. You and Your DoctorChapter 12. Dealing with DisabilityChapter 13. Getting Involved with the MS CommunityChapter 14. Finding BalanceConclusionAppendix: The Facts About MSResourcesReferencesIndex
£17.58
John Wiley and Sons Ltd Immunology
Book SynopsisImmunology: A Concise Review offers the essential and basic ideas of immunology as a quick reference for students, practitioners, and veterinary technicians. Although concise, the book is comprehensive and a knowledge of its contents will assure the reader a relatively thorough understanding of what is frequently a difficult subject. The book covers all of the basics of immunology, including chapters on: the origin and function of hemopoietic and lymphopoietic cells; non-specific immunity; antigens; complement; cell receptors and cytokines associated with the immune response; specific immune responses; responses to bacteria, fungi, protozoa, helminths, and tumors. More advanced topics include: an examination of all four hypersensitivity reactions; autoimmunity; immune deficiency diseases; organ transplant and rejection; vaccination and immunization; and immunodiagnostic techniques. Additionally, the book offers end of chapter glossaries and a cumulative glossary as wTable of ContentsPreface; Abbreviations and Greek Letters; Introducing immunology; The hemopoietic and lymphopoietic cells; natural immunity and resistance; The nature of antigens and immunogens; The complement system; T cell receptors, major histocompatibility complex and cytokines; The humoral immune response; The cell-mediated immune response; The immune system in action; Hypersensitivity reactions, allergy and anaphylaxis; Hypersensitivity reactions, cytotoxic/cytolytic, immune complex and delayed type; Autoimmunity; Immune deficiency diseases; immune deficiency diseases; Transplant/graft rejection; vaccination/immunisation; Immunodiagnostic techniques; Cumulative Glossary; Index
£55.76
CABI Publishing Nutrition Immunity and Infection
Book SynopsisInfectious diseases are an important cause of malnutrition. Recurrent infections increase the risk of malnutrition while poor nutritional status results in lowered immune status and predisposes to infectious disease thus propagating the vicious cycle of infection and malnutrition. The nutrition-infection-immunity axis is crucial for both developed and developing countries and is now a central feature of many nutrition and infectious disease courses.Bringing together nutrition and immunology, Nutrition, Immunity and Infections covers the topic in an accessible format for all students of nutrition, medicine and public health. Through his work at the London School of Hygiene and Tropical Medicine, the FAO's Food and Nutrition Division and his current post at the University of Southampton, Professor Shetty has built a reputation to match his wealth of experience in the relationship between nutrition and susceptibility to infection.Table of ContentsSECTION 1: Introduction 2: Defence mechanisms of the body 3: Nutrients in food 4: Role of nutrients in infection and immune functions 5: Effects of under nutrition on host defence mechanisms and the immune response SECTION 2: Role of infections in the aetiology and pathogenesis of under nutrition 7: Vitamin A deficiency and risk of infection 8: Zinc deficiency and infections 9: Iron status and risk of infection SECTION 3: Nutrition and diarrhoeal disease 11: Nutrition and parasitic infections 12: Nutrition and HIV/AIDS 13: Nutrition and tuberculosis SECTION 4: Nutrition and infection in infancy and childhood 15: Maternal nutrition and infection 16: Nutrition and infection in the elderly and aged 17: Relationships between infections and non-communicable diseases"
£42.99
CABI Publishing Nutrition and Immune Function
Book SynopsisThis book provides a review of the roles of specific nutrients in maintaining the immune response and host protection against infection. It also considers the influence of various factors, such as exercise and ageing, on the interaction between nutrition and immune function. The main emphasis is on humans, but comparative mammalian data are also presented.The contents include methods for studying nutrient-immune function interactions, the impact of undernutrition on immune function and infection, the influences of fatty acids, amino acids, antioxidant vitamins, and various minerals on immunity, immunological effects of changes throughout the life cycle, and public health policy implications.Table of ContentsPart I: The Immune System 1: The immune system - An overview, G Devereux, Aberdeen Royal Infirmary, Aberdeen, UK 2: Evaluation of the effects of nutrients on immune function, S Cunningham-Rundles, Cornell University Weill Medical College, USA Part 2: Individual Nutrients, Infection and Immune Function 3: Effect of post-natal protein malnutrition and intrauterine growth retardation on immunity and risk of infection, R K Chandra, Janeway Child Health Centre, St John’s, NF, Canada 4: Fatty acids, inflammation and immunity, P C Calder and C J Field 5: Arginine and immune function, M D Duff and J M Daly, Cornell University, USA 6: Glutamine and immune function, P C Calder and P Newsholme, University College of Dublin, Ireland 7: Sulphur amino acids, glutathione and immune function, R F Grimble, University of Southampton, UK 8: Vitamin A, infection and immune funtion, R D Semba, Johns Hopkins University School of Medicine, Baltimore, USA 9: Antioxidant vitamins and immune function, D A Hughes, Institute of Food Research, Norwich, UK 10: Zinc, infection and immune function, A S Prasad, Wayne State University School of Medicine, Detroit, USA 11: Role of iron in immunity and infection, S Kuvibidila, Louisiana State University, USA and B S Baliga, University of South Alabama, USA 12: Selenium and the immune system, R C McKenzie, University of Edinburgh, UK, J R Arthur, Rowett Research Institute, Aberdeen, UK, S M Miller, T S Rafferty and G J Beckett, University of Edinburgh, UK 13: Probiotics and immune function, H S Gill and M L Cross, Massey University, New Zealand Part 3: Nutrition and Immunity through the Life Cycle 14: Role of local immunity and breast feeding in mucosal homeostasis and defence against infection, P Brandtzaeg, University of Oslo, Norway 15: Food allergy, E Opara, Kingston University, UK 16: Exercise and immune function - effect of nutrition, E W Petersen and B K Pederson, Copenhagen Muscle Research Centre, Denmark 17: Nutrition and aging of the immune system, B Lesourd, A Raynaud-Simon and L Mazari, Hopital Nord du CHU de Clermont Ferrand, France 18: Nutrition and immunity - Public health implications, A Tomkins, Centre for International Child Health, London, UK
£108.90
Humana GraftVersusHost Disease
Book SynopsisGraft-Versus-Host Disease Mouse Models: A Clinical-Translational Perspective.- Xenogeneic Animal Models of Graft-Versus-Host Disease.- Utilisation of Clinical Data and Evaluation of Biomarkers in the Investigation of Graft-Versus-Host Disease Outcomes.- Endothelial Activation and Stress Index (EASIX) – A Prognostic Marker for Mortality After Acute Graft-Versus-Host-Disease and Endothelial Complications.-
£224.99
Humana Cancer Vaccines
Book SynopsisCurrent Landscape of Therapeutic Cancer Vaccines.- The Tumor Immune Environment: Advances in the Cancer Immunotherapy Era.- Making Universal Vaccines and Antibodies through Glycoengineering.- Dendritic Cell Cancer Vaccines: A Focused Review.- Mouse Model of Brain Tumor Resection.- Mouse Model of Viral Induced Brain Tumor and Generation of a Stable Tumor-Derived Cell Line.- Stereotaxic Genetic Perturbation of the Tumor Microenvironment in the Rodent Brain.- Nuclear Morphology-Based Assessment of Cell Fates Induced by a Microtubule Targeting Agent as a Single Treatment or Combined with an Oncolytic Virus.- Viral Vector-Based Cancer Vaccines.- Nanoparticles-Assisted Peptide Cancer Vaccine Delivery.- Biomimetic Glyconanoparticle Nanoghost Vaccine Based on Red Blood Cells.- Amphiphilic Glycoprobes for Cell Surface Engineering and Drug Delivery.- The Production and Characterization of Synthetic Glycoconjugate Vaccines.- Phage Display Isolation of VHH Antibodies Targeting Capsular Polysaccharides of Intratumor Bacteria.- Development of ELISA Assay for Antibody Detection in Cancer Vaccine Research.- Dendritic Cell Cancer Vaccines: Clinical Production for Cancer Immunotherapy.
£149.00
£196.65
John Wiley and Sons Ltd Neuroimmunology in Clinical Practice
Book SynopsisWritten by field experts, Neuroimmunology in Clinical Practice fills a void in traditional neuroimmunology literature, which tends to cover the discipline's scientific aspects with little emphasis on clinical applications. This unique book is essential reading in clinical neuroimmunology.Trade Review“This unique book is essential reading in clinical neuroimmunology. Written by field experts this book provides a comprehensive description of immune mediated neurological disorders complemented with the most pertinent and up to date scientific data.” (Immortality Medicine, 27 December 2012) Table of ContentsPreface. Foreword. Contributing Authors. Part I: Basic Science Introduction to Clinical Neuroimmunology. Editor: Bernadette Kalman. 1. The basics of cellular and molecular immunology. Amy Lovett-Racke, Anne R. Gocke, and Petra D. Cravens. 2. Major components of myelin in the mammalian central and peripheral nervous systems. Alexander Gow. Part II: Inflammatory Demyelination in the Central Nervous System. Editor: Bernadette Kalman. 3. Multiple sclerosis. 3.1 Epidemiology and genetics. Bernadette Kalman. 3.2 Immunopathogenesis. Thomas P. Leist. 3.3 Courses and diagnosis of MS. Bernadette Kalman. 3.4 Clinical features. Bernadette Kalman. 3.5 The pathology of MS: a quest for clinical correlation. William F. Hickey. 3.6 Cerebrospinal fluid. Mark Freedman. 3.7 Magnetic resonance imaging characteristics of MS. Jennifer L. Cox and Robert. Zivadinov. 3.8 Treatment of MS. Sean J. Pittock. 4. Devic’s disease. Bernadette Kalman. 5. Acute disseminated encephalomyelitis and related conditions. Robert S. Rust. Part III: Autoimmune Diseases of the Peripheral Nervous System and the Muscle. Editor: Thomas H. Brannagan III. 6. Guillain-Barre Syndrome. Eduardo A. De Sousa and Thomas H. Brannagan III. 7. Immune mediated chronic demyelinating polyneuropathies. Thomas H. Brannagan III. 8. Immune mediated autonomic neuropathies. Louis H. Weimer and Mill Etienne. 9. Autoimmune myasthenic syndromes: myasthenia gravis and Lambert-Eaton myasthenic syndrome. Andrew Sylvester and Armistead Williams. 10. Polymyositis and dermatomyositis. S. Christine Kovacs. Part IV: Disorders of the Central and Peripheral Nervous Systems Related to Known or Assumed Systemic Immune Abnormalities. Editor: Bernadette Kalman. 11. Neuro-Sjögren's syndrome. Bernadette Kalman. 12. Neuro-Behcet's syndrome. Bernadette Kalman. 13. Steriod responsive encephalopathy associated with Hashimoto's thyroiditis. Bernadette Kalman. 14. Rasmussen encephalitis. Bernadette Kalman. 15. Susac’s syndrome. Bernadette Kalman. 16. Cogan’s syndrome. Bernadette Kalman. 17. Neurosarcoidosis. Bernadette Kalman. 18. Anti-VGKC syndromes: Isaac's syndrome, Morvan syndrome and Autoimmune limbic encephalitis. Bernadette Kalman. 19. Paraneoplastic neurological autoimmunity. Daniel Lachance and Vanda. Lennon. 20. Vasculitis and connective tissue disorders. David S. Younger and Adam P.J. Younger. 21. Post-streptococcal movement disorders. Gavin Giovannoni and Andrew Church. 22. Neurological manifestations of gluten sensitivity. Marios Hadjivassiliou. 23. Anti-GAD associated neurological diseases. Marios Hadjivassiliou. Index
£164.95
John Wiley and Sons Ltd Autoimmunity, Part A: Basic Principles and New
Book SynopsisThe incidence of autoimmune diseases is increasing worldwide, and the search for better management of these diseases and even for a cure is being pursued by scientists from many disciplines. Tools from the areas of genetics, neuroscience, cell biology, virology, and infectious disease are being applied to the problem and are yielding useful results. This volume contains the first section of the proceedings of a large, comprehensive meeting held in Sorrento, Italy. Because the meeting focused on such an important area of human health, four volumes have been dedicated to it: Part A presents new principles in autoimmunity, including the roles of key players such as designed ankyrin repeat proteins, SLAM-associated protein, interleukin-12, human proteinase 3, the complement system, IgG, disturbances in cytokine synthesis, and IFN-γ blockers. The second section of the volume takes a look at new diagnostic tools, including screening of endothelial expression libraries, electrical skin impedance, and IgA anti-tissue transglutaminase antibody assays. Autoimmunity, Part B continues the presentation of basic research and its applications with a focus on genetics. Parts C and D present the clinical research in various manifestations of autoimmune disease and its treatments. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a memberTable of ContentsForeword (M. Eric Gershwin and Yehuda Shoenfeld). Part I: New Principles of Autoimmunity. 1. The Nature and Nurture of Common Autoimmunity (John Castiblanco and Juan-Manuel Anaya). 2. Designed Ankyrin Repeat Proteins as Anti-Idiotypic Binding Molecules (Monique Vogel, Elsbeth Keller-Gautschi, Michael J. Baumann, Patrick Amstutz, Christine Ruf, Franz Kricek, Beda M. Stadler). 3. SLAM-Associated Protein (SAP) Solves a Mystery of Autoimmunity: (Shigemasa Sawada, Masami Takei, Tetsuyosi Ishiwata, Hidetaka Shiraiwa, Hirotake Inomata, Takamasa Nozaki). 4. Standardization of Autoimmune Diagnostics in Germany – Activities of the German Group in the European Autoimmune Standardisation Initiative (Ulrich Sack, Karsten Conrad, Elena Csernok, Ingrid Frank, Michael Haass, Torsten Krieger, Michael Seyfarth, Udo Schlosser, Reinhold E. Schmidt, Torsten Witte). 5. Autoimmunity and Time Entanglement (Juan I. Poo, Pablo I. Martin, Enrique Rewald). 6. The Pro- and Anti-Inflammatory Potential of Interleukin-12 (Hyun-Dong Chang, Andreas Radbruch). 7. NKG2D and Natural Cytotoxicity Receptors Are Involved in Natural Killer Cell Interaction with Self-Antigen Presenting Cells and Stromal Cells (Poggi Alessandro, Prevosto Claudia, Zancolli Marta, Paolo Canevali, Alessandra Musso, Zocchi Maria Raffaella). 8. The Role of Toll-Like Receptors in HMGB1 Release from Macrophages (David S. Pisetsky, Weiwen Jiang). 9. Immune Complex Pathophysiology (Urs E. Nydegger). 10. Human Proteinase 3 (PR3) and Its Binding Molecules: Implications for Inflammatory and PR3-Related Autoimmune Responses (Antje Müller, Jan Voswinkel, Stefan Gottschlich, Elena Csernok). 11. Loss of Self-Control in the Complement System and Innate Autoreactivity (Seppo Meri). 12. Immunodeficiency and Autoimmune Phenomena in Female Hyper IgM Syndrome (HIGM) (Melegari Alessandra, Mascia Maria Teresa, Sandri Gilda, Carbonieri Anna). 13. Autoimmune Diseases of Domestic Animals (Laurel J. Gershwin). 14. Prediction and Prevention of Autoimmune Disease: A Personal Perspective (Noel R. Rose). 15. Alterations of Th1/Th2 Reactivity by Heavy Metals: Possible Consequences Include Induction of Autoimmune Diseases (Nasr Y.A. Hemdan, Frank Emmrich, Sonya Faber, Ulrich Sack). 16. EASI – The European Autoimmunity Standardisation Initiative: A New Initiative That Can Contribute to Agreed Diagnostic Models of Diagnosing Autoimmune Disorders Throughout Europe (Yehuda Shoenfeld, Ricard Cervera, Michael Haass, Cees Kallenberg, Munther Khamashta, Pier Luigi Meroni, Jean-Charles Piette, Reinhold Schmidt, Allan Wiik). 17. Effector Memory CD8+ T Cells Are Resistant to Apoptosis (Sudhir Gupta, Sastry Gollapudi). 18. Two-Step Mechanism of Virus-Induced Autoimmune Hemolytic Anemia (Jean-Paul Coutelier, Laurent Detalle, Andrei Musaji, Mory Meite, Shozo Izui). 19. Autoimmune Reactions After Electro-Oxidation of IgG from Healthy Persons. Relevance of Electric Current and Antioxidants (Borut Bozic, Sasa Cucnik, Tanja Kveder, Blaz Rozman). 20. Autoimmune Diseases Are Connected With Disturbances In Cytokine Synthesis and Therapy With IFN-g Blockers Is Their Main Pathogenetic Treatment (Boris Skurkovich, Simon Skurkovich). Part II: New Tools in Diagnosis. 21. Screening of Endothelial Expression Libraries for the Identification of Novel Autoantigens Involved in Distinct Autoimmune Diseases Characterized by Endothelial Dysfunction (Paola Margutti, Federica Delunardo, Tania Colasanti, Ettore Piro, Elisabetta Profumo, Rachele Riganò, Alessandra Siracusano, Brigitta Buttari, Fabrizio Conti, Cristiano Alessandri, Antonella Capozzi, Maurizio Sorice, Elena Ortona). 22. Diagnosing Diseases by Mesurement of Electrical Skin Impedance: A Novel Technique (Rony Weitzen, Nava Epstein, Yehuda Shoenfeld, Eyal Zimlichman). 23. Antigen Preparation for Immunological Studies in Systemic Autoimmune Diseases (Sandra Zampieri, Anna Ghirardello, Katia Rossini, Luca Iaccarino, Nicola Bassi, Fabiola Atzeni, PierCarlo Sarzi-Puttini, Andrea Doria). 24. Comparison of Two Elisa Assays for Anti-SP100 Determination (José Manuel Lucena, Marcos Montes Cano, José Luis Caro, Nieves Respaldiza, Antonia Alvarez, Julio Sánchez-Román, Antonio Núñez-Roldán, Ingeborg Wichmann). 25. Diagnostic Accuracy of IgA Anti-Tissue Transglutaminase Antibody Assays in Celiac Disease Patients with Selective IgA Deficiency (D. Villalta, M.G. Alessio, M. Tampoia, E. Tonutti, I. Brusca, M. Bagnasco, G. Pesce, N. Bizzaro). 26. Anti-Topoisomerase 1 Antibodies in Systemic Sclerosis: How to Improve the Detection (Mathieu C. Tamby, Guillaume Bussone, Luc Mouthon). 27. The Effect of Open Heart Surgery on Tuberculin Skin Test Reactivity (Michal Stein, Batia Sela-Razon, Ilan Linder, Eli Somekh). 28. The Reliability of Control Skin Tests with Common Antigens in Children Undergoing Tuberculin Skin Test (Michal Stein, Batia Sela-Razon, Yeshayaou Kleter, Eli Somekh). 29. Ena Screen Chemiluminescence Immunoassay: A Random Access Method in Autoimmunology (S. Signorini, I. Kutschera, F. Capuano, L. Lattuada). 30. Evaluation of the BioPlex 2200™ ANA Screen for the Detection of Anti-Nuclear Antibodies and Comparison with Conventional Methods (Sophie Desplat-Jego, Nathalie Bardin, Bruno Larida, Marielle Sanmarco). 31. A New Line Immunoassay for the Multiparametric Detection of Anti-Ganglioside Autoantibodies in Patients with Autoimmune Peripheral Neuropathies (Karsten Conrad, Hauke Schneider, Tjalf Ziemssen, Thomas Talaska, Dirk Reinhold, Rene-Louis Humbel, Dirk Roggenbuck). 32. Lipocalin-2, Tweak and Other Cytokines as Urinary Biomarkers for Lupus Nephritis (Noa Schwartz, Jennifer S. Michaelson, Chaim Putterman). 33. The Prevalence of Anti-Nucleosome Antibodies by Enzyme-Linked Immunosorbent Assays (ELISA) in Patients with Systemic Lupus Erythematosus and Other Autoimmune Systemic Diseases (I. Putova, C. Dostal, R. Becvar). 34. Predictive Value of Antibodies to Citrullinated Peptides and Rheumatoid inbFactors Treated Patients (Francesca Bobbio-Pallavicini, Roberto Caporali, Anti-TNF- Claudia Alpini, Remigio Moratti, Carlomaurizio Montecucco). 35. Redox-Reactive Autoantibodies in Cerebrospinal Fluids (John A. McIntyre, Ronald L. Hamilton, Steven T. DeKosky). 36. Determination of Oxidized Low-Density Lipoproteins 2GPI Complexes for the (OxLDL) Versus OxLDL/ Atherosclerosis (Luis R.bAssessment of Autoimmune-Mediated Lopez, Tammmy R. Buckner, Beth L. Hurley, Kazuko Kobayashi, Eiji Matsuura). 37. Serological and Clinical Characterization of Anti-dsDNA and Anti-PM/Scl Double Positive Patients (M. Mahler, E.L. Greidinger, M. Szmyrka, A. Kromminga, M.J. Fritzler). 38. Performance of ANA CTD Screen as Screening for Connective Tissue Diseases (Marcos López-Hoyos, Vicente Rodríguez-Valverde, Victoria Martinez-Taboada). 39. Multiplex Assays to Diagnose Celiac Disease (Ivo Lochman, Peter Martis, Rufus W. Burlingame, Alexandra Lochmanová). 40. Could Serum Antibody to Poly(ADP-ribose) and/or Histone H1 be Marker for Senile Dementia of Alzheimer Type (Y. Kanai, H. Akatsu, H. Iizuka, C. Morimoto). 41. Identification by Proteomic Tool of Atypical Anti-Liver/Kidney-Microsome Autoantibodies Targets in de novo Auto-Immune Hepatitis After Liver Transplantation (S. Huguet, J. Vinh, C. Johanet, D. Samuel, M. Gigou, O. Zamfir, J.C. Duclos-Vallee, E. Ballot). 42. Automatic Analysis of Immunofluorescence Patterns of HEP-2 Cells (Rico Hiemann, Nadja Hilger, Jörg Michel, Jörg Nitschke, Alexander Böhm, Ursula Anderer, Martin Weigert, Ulrich Sack). 43. Exploring cDNA Phage Display for Autoantibody Profiling in Serum of Multiple Sclerosis Patients: Optimization of the Selection Procedure (C. Govarts, K. Somers, R. Hupperts, P. Stinissen, V. Somers). 44. Novel Biomarkers in Autoimmune Diseases Prolactin, Ferritin, Vitamin D and TPA Levels in Autoimmune Diseases (Hedi Orbach, Gisele Zandman-Goddard, Howard Amital, Vivian Barak, Zoltan Szekanecz, Gabriella Szucs, Katalin Danko, Endre Nagy, Tunde Csepany, Jozelio F. Carvalho, Andrea Doria, Yehuda Shoenfeld). 45. Evaluation of Current Methods for the Measurement of Serum Anti-Double Stranded DNA Antibodies (Anna Ghirardello, Danilo Villalta, Gabriella Morozzi, Antonella Afeltra, Mauro Galeazzi, Robert Gerli, Alessandro Mathieu, Pier Luigi Meroni, Paola Migliorini, Antonella Radice, Valeria Riccieri, Amelia Ruffatti, Gian Domenico Sebastiani, Angela Tincani, Andrea Doria). 46. Evaluation of the Liaison ANA Screen Assay for Antinuclear Antibody Testing in Autoimmune Diseases (P. Ghillani, A.M. Rouquette, C. Desgruelles, N. Hauguel, C. Le Pendeven, J.C. Piette, L. Musset). 47. Clinical Significance of Anti-Histidyl-tRNA Synthetase (Jo1) Autoantibodies (Emeline Gomard-Mennesson, Nicole Fabien, Jean-Francois Cordier, Jacques Ninet, Jacques Tebib, Hugues Rousset). 48. Antinucleosome Antibodies and Systemic Lupus Erythematosus (Nursen Düzgün, Mehmet Sahin, Yasemin Genç, Hüseyin Tutkak). 49. Protein Expression Profile of Celiac Disease Patient with Aberrant T-Cell By Two-Dimensional Difference Gel Electrophoresis (Valli De Re, Maria Paola Simula, Laura Caggiari, Nicoletta Ortz, Michele Spina, Alessandro Da ponte, Leandro De Appolonia, Riccardo Dolcetti, Vincenzo Canzonieri, Renato Cannizzaro). 50. The Chemokine Profile of the Different Inflammatory Myopathies Reflects the Humoral Versus Cytotoxic Immune Responses (Boel De Paepe, Kim K. Creus, Jan L De Bleecker). 51. Evaluation of the FIDIS Multiplex Immunoassay for Diagnosis and Follow-Up of ANCA-Associated Vasculitis and Goodpasture’s Disease (J. Damoiseaux, M. Vaessen, Y. Knapen, E. Csernok, C.A. Stegeman, P. van Paassen, J.W. Cohen Tervaert). 52. Comparison of Three Multiplex Immmunoassays for Detection of Antibodies to Extractable Nuclear Antibodies Using Clinically Defined Sera (Susan S. Copple, Thomas B. Martins, Charlin Masterson, Erwann Joly, Harry R. Hill). 53. Identification of Histidine-Rich Glycoprotein, a Potential Autoantigen, in Human and Rat Brain Preparations (Catrin Ball-Rosen, Hagit Primak-Rubinovicz, Amos D. Korczyn, Ningshan Wang, Adel Farchi, Sara Shavit, Yehuda Shoenfeld, Joab Chapman). 54. An Analysis of Experimental 2Glycoprotein I Elisa Assay Results: Conditions Influencing the Anti- (Anna Cavazzana, Amelia Ruffatti, Marta Tonello,bAnna Maria Bortolati, Philippe de Moerloose, Guido Reber). 55. Development of Automated Assays for Anti Cardiolipin Antibodies Determination: Addressing Antigen/Solid-Phase and Standardization Issues (Francesco Capuano, Valentina Grasso, L. Belforte, Luca Pallavicini, Fabrizio Bonelli). 56. Biological and Clinical Relevance of Anti-Prothrombin Antibodies (Anna Ghirardello, Nicola Bizzaro, Sandra Zampieri, Luca Iaccarino, Nicola Bassi, Renato Tozzoli, Amelia Ruffatti, Danilo Villalta, Elio Tonutti, Andrea Doria). 57. Clinical Evaluation of a New Quantitative Enzyme Linked Immunosorbent Assay for Detection of Double Stranded DNA Autoantibodies (Nathalie Bardin, Celine Ragot, Marielle Sanmarco). 58. Characterization of Autoantibodies Against Components of the Nuclear Pore Complexes: High Frequency of Anti-p62 Nucleoporin Antibodies (Jozefa Wesierska-Gadek, Anna Klima, Oxana Komina, Carmen Ranftler, Pietro Invernizzi, Edward Penner). 59. Anti-Cardiolipin and Anti-Beta2Glycoprotein-I Antibdies: Performance of New Commercial Elisa Kits (Laura Andreoli, Fabio Malacarne, Angela Ceribelli, Iris Kutschera, Angela Tincani). 60. A Combined SDS-PAGE and Proteomics Approach to Identify Target Autoantigens in Healthy Individuals and Patients with Autoimmune Diseases (Philippe Guilpain, Amélie Servettaz, Mathieu C. Tamby, Youri Chanseaud, Nicolas Tamas, Paloma Garcia de la Pena-Lefebvre, Cédric Broussard, Luc Camoin, Luc Mouthon). 61. Anti-Vitamin D, Vitamin D in SLE: Preliminary Results (Jozélio Freire de Carvalho, Miri Blank, Emese Kiss, Tunde Tarr, Howard Amital, Yehuda Shoenfeld). Index of Contributors.
£103.05
John Wiley and Sons Ltd The Year in Immunology: Immunoregulatory
Book SynopsisThe fourth installment of "The Year in Immunology" series features reviews of novel approaches in the investigation of immunoregulatory mechanisms. Topics surveyed include cutting-edge molecular studies and treatment advances for systemic lupus erythmatosus and multiple sclerosis, the genetic regulation of lymphocytes and T cells, and new models of immunosenescence. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.Table of ContentsPreface Noel R. Rose Lymphoid tissue inducer cells: innate cells critical for CD4+ T cell memory responses? Peter J.L. Lane, Fabrina M. Gaspal, Fiona M. McConnell, Mi Yeon Kim, Graham Anderson and David R. Withers Regulation of mature T cell responses by the Wnt signaling pathway Hai-Hui Xue and Dong-Mei Zhao Development and function of interleukin 17-producing ?d T cells: Thomas Korn and Franziska Petermann Lymphocyte signaling: regulation of FoxO transcription factors by microRNAs Claudia Haftmann, Anna-Barbara Stittrich, Evridiki Sgouroudis, Mareen Matz, Hyun-Dong Chang, Andreas Radbruch and Mir-Farzin Mashreghi From interleukin-9 to T helper 9 cells Michael Stassen, Edgar Schmitt and Tobias Bopp Mechanisms of immunosenescence: lessons from models of accelerated immune aging Sabine Le Saux, Cornelia M. Weyand and Jörg J. Goronzy Helminth–host immunological interactions: prevention and control of immune-mediated diseases David E. Elliott and Joel V. Weinstock Induction of gut IgA production through T cell-dependent and T cell-independent pathways Mats Bemark, Preben Boysen and Nils Y. Lycke New and emerging disease modifying therapies for multiple sclerosis Shiv Saidha, Christopher Eckstein and Peter A. Calabresi Treatment of systemic lupus erythematosus: new advances in targeted therapy Mindy S. Lo and George C. Tsokos
£109.25
John Wiley and Sons Ltd The Year in Immunology: Basic and Clinical
Book SynopsisThis volume of The Year in Immunology series features reviews of topics in human immunology, including B1 B cells, BCL-2 family members, Wiskott-Aldrich syndrome, reverse vaccinology, anti-b2-glycoprotein I, the role of autoimmunity In thromboangiitis obliterans (Buerger's Disease), long pentraxin PTX3 as a paradigm for humoral pattern recognition molecules, and control of inflammatory heart disease by CD4+ T cells.Table of ContentsThe proper study: preface to The Year in Immunology v Noel R. Rose The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules 1 Alberto Mantovani, Sonia Valentino, Stefania Gentile, Antonio Inforzato, Barbara Bottazzi, and Cecilia Garlanda The role of autoimmunity in thromboangiitis obliterans (Buerger’s disease) 15 Siva S. Ketha and Leslie T. Cooper Wiskott-Aldrich syndrome: a comprehensive review 26 Michel J. Massaad, Narayanaswamy Ramesh, and Raif S. Geha Anti-β₂-glcoprotein I antibodies 44 Rohan Willis and Silvia S. Pierangeli Getting away with murder: how does the BCL-2 family of proteins kill with immunity? 59 Thibaud T. Ranault and Jerry E. Chipuk Control of inflammatory heart disease by CD4+ T cells 80 Jobert G. Barin and Daniela Čiháková Human B-1 cells take the stage 97 Thomas L. Rothstein, Daniel O. Griffin, Nichol E. Holodick, Tam D. Quach, and Hiroaki Kaku Reverse vaccinology in the 21st century: improvements over the original design 115 Claudio Donati and Rino Rappuoli The National Institutes of Health Center for Human Immunology, Autoimmunity, and Inflammation: history and progress 133 Howard B. Dickler, J. Philip McCoy, Robert Nussenblatt, Shira Perl, Pamela A. Schwartzberg, John S. Tsang, Ena Wang, and Neil S. Young
£104.50
John Wiley and Sons Ltd Neuroimunomodulation in Health and Disease II:
Book SynopsisThis is the second of two Annals volume (see also Volume 1262) of papers by speakers at the 8th International Society for Neuroimmodulation Congress held in Dresden, Germany, October 2011. The papers focus on interactions among the immune, endocrine, and nervous systems that occur at multiple levels, from intracellular pathways by immune and neuro-endocrine mediators, to the exchange of information between the three systems that results in physiologic and adaptive effects. In certain instances, however, these interactions may be unbalanced or even disrupted, which can contribute to pathology, and aspects of such pathobiology are presented in some of the contributions. This volume aims focuses on translational science aspects of immune-neuro-endocrine interactions. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Sciences receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.Table of ContentsThymic atrophy in acute experimental Chagas disease is associated with an imbalance of stress hormones Ailin Lepletier Vinícius de Frias Carvalho Alexandre Morrot Wilson Savino 45 Endocrine, metabolic, and immunologic components of HIV infection Guido Norbiato 51 Neuroimmunomodulation and neuropsychiatric diseases Autoimmune diseases and infections as risk factors for schizophrenia Michael E. Benros Preben B. Mortensen William W. Eaton 56 Antidepressants prevent hierarchy destabilization induced by lipopolysaccharide administration in mice: a neurobiological approach to depression Daniel Wagner Hamada Cohn Denise Kinoshita João Palermo-Neto 67 Peripheral immune system and neuroimmune communication impairment in a mouse model of Alzheimer's disease Lydia Giménez-Llort Ianire Maté Rashed Manassra Carmen Vida Mónica De la Fuente 74 Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and β-amyloid accumulation in adult mice Toshihiko Katafuchi Masataka Ifuku Shiro Mawatari Mami Noda Kiyotaka Miake Masaaki Sugiyama Takehiko Fujino 85 Biological memory of childhood maltreatment: current knowledge and recommendations for future research Katharina Schury Iris-Tatjana Kolassa 93 Neuroimmunomodulation of pain, and neoplastic diseases Chronic neuropathic pain-like behavior and brain-borne IL-1β Adriana del Rey A. Vania Apkarian Marco Martina Hugo O. Besedovsky 101 Experimental endotoxemia as a model to study neuroimmune mechanisms in human visceral pain Sven Benson Harald Engler Manfred Schedlowski Sigrid Elsenbruch 108 The neuroimmune connection interferes with tissue regeneration and chronic inflammatory disease in the skin Eva M.J. Peters Christiane Liezmann Burghard E. Klapp Johannes Kruse 118 17α-androstenediol-mediated oncophagy of tumor cells by different mechanisms is determined by the target tumor Roger M. Loria Martin R. Graf 127 Cellular and molecular players in the atherosclerotic plaque progression Rita Businaro Angela Tagliani Brigitta Buttari Elisabetta Profumo Flora Ippoliti Claudio Di Cristofano Raffaele Capoano Bruno Salvati Rachele Riganò 134
£53.55
American Academy of Pediatrics Pediatric Allergies: A Clinical Support Chart
Book SynopsisThis convenient reference provides clinicians with point-of-care guidance on the assessment and treatment of pediatric allergies in children of all ages, from infants to young adults. This quick reference tool is perfect to have on hand during evaluation, diagnosis, determination of treatment course, and communication with patients and parents about trigger management at home, as well as covers management strategies, customized treatment plans, referrals, and follow-ups. The chart covers allergens, allergy signs and symptoms (including food allergies), triggers, diagnostic considerations, anaphylaxis recognition and management, allergy testing and treatment protocols (including desensitization and immunotherapy), reactions to medications, differential diagnosis of dermatitis, atopy, and more. CONTENTS INCLUDE Allergic Conjunctivitis Allergic Rhinitis Respiratory Exposures Remediation Strategies for Common Respiratory Allergens Mold Exposures Mold-Related Illness and Health Effects Hymenoptera Venom Allergy Classic Reactions to Antibiotics Immediate Reactions to Antibiotics Nonimmediate Reactions to Antibiotics Nickel Allergy Latex Allergy Diagnosis of Atopic Dermatitis Treatment of Atopic Dermatitis Avoiding Eczema Triggers Food Allergies Cow’s Milk Allergy Peanut Allergy Anaphylaxis Recognition Anaphylaxis Treatment AAP Allergy and Anaphylaxis Emergency Plan Allergy Testing Immunotherapy Table of ContentsTab 1. Allergic ConjunctivitisTab 2. Allergic RhinitisTab 3. Respiratory ExposuresTab 4. Remediation Strategies for Common Respiratory AllergensTab 5. Mold ExposuresTab 6. Mold-Related Illness and Health EffectsTab 7. Hymenoptera Venom AllergyTab 8. Classic Reactions to AntibioticsTab 9. Immediate Reactions to AntibioticsTab 10. Nonimmediate Reactions to AntibioticsTab 11. Nickel AllergyTab 12. Latex AllergyTab 13. Diagnosis of Atopic DermatitisTab 14. Treatment of Atopic DermatitisTab 15. Avoiding Eczema TriggersTab 16. Food AllergiesTab 17. Cow’s Milk AllergyTab 18. Peanut AllergyTab 19. Anaphylaxis RecognitionTab 20. Anaphylaxis TreatmentTab 21. AAP Allergy and Anaphylaxis Emergency PlanTab 22. Allergy testingTab 23. Immunotherapy
£43.20
Thieme Medical Publishers Inc Thieme Test Prep for the USMLE®: Medical
Book SynopsisEnsure readiness for the USMLE® or any other high-stakes exam covering microbiology and immunology! Thieme Test Prep for the USMLE®: Medical Microbiology and Immunology by Melphine Harriott, Michelle Swanson-Mungerson, Samia Ragheb, and Matthew Jackson covers major topics taught in immunology and microbiology courses during the first and second year of medical school. Readers will learn how to recall, analyze, integrate, and apply microbiology and immunology knowledge to solve clinical problems. Key Highlights 550 USMLE®-style multiple choice questions classified as easy, moderate, and difficult, including detailed explanations Microbiology questions organized by organ system that cover major infectious diseases Immunology questions organized by concept including chapters on inflammation, autoimmune diseases, immunodeficiency disorders, hypersensitivity reactions, and transplant rejection and anti-tumor responses This essential resource will help you assess your knowledge and fully prepare for the USMLE® Step 1 or COMLEX Level 1 exam. Be prepared for your board exam with the Thieme Test Prep for the USMLE® series! Das: Histology and Embryology Q&A Das and Baugh: Medical Neuroscience Q&A Fontes and McCarthy: Medical Biochemistry Q&A Hankin et al.: Clinical Anatomy Q&A Kemp and Brown: Pathology Q&A Waite and Sheakley: Medical Physiology Q&A Visit www.thieme.com/testprep to learn more about our online board review question bank.Table of ContentsSection I Immunology 1 General Immunology 2 Inflammation 3 Autoimmune Diseases 4 Immunodeficiency Disorders 5 Hypersensitivity Reactions 6 Transplant Rejection and Cancer Immunology Section II Microbiology 7 General Microbiology 8 Nervous System Infections 9 Head, Neck, and Respiratory Infections 10 Infections of the Esophagus, Stomach, Small and Large Bowel/Rectum, Liver and Biliary Tree 11 Renal and Urinary Tract Infections 12 Reproductive and Sexually Transmitted Infections 13 Congenital and Neonatal Infections 14 Skin, Soft Tissue, and Musculoskeletal Infections 15 Cardiovascular, Systemic, Lymph Nodes, and Multi-System Infections
£36.57
Grey House Publishing Inc Principles of Health: Allergies & Immune
Book SynopsisThis volume covers allergies, defined as hypersensitivity to the immune system, and immune disorders, which are dysfunctions of the immune system classified as different from allergies based on immune system disorders. Readers will explore allergies to common allergens, like pollen and certain foods, as well as a variety of immune disorders, such as lupus and rheumatoid arthritis. Coverage includes causes, prevalence, and treatments. Topics in this volume include: Signs and symptoms Food allergies Drug allergies Environmental allergies Genetics Immunodeficiencies Asthma Acute response Late-phase response Essays are comprehensive and accessible to high school students, undergraduates, and general readers interested in learning more about allergies, allergens, and immune disorders. Each essay includes multiple subheads including an opening Summary and Further Reading. The volume ends with a Glossary, Bibliography, and Subject Index.
£131.20
Rutgers University Press Anthony Cerami: A Life in Translational Medicine
Book SynopsisSince the turn of the new millennium, ‘translational research’, the scientific process of bringing disease-targeted knowledge from the laboratory to treat patients in the clinic, has gone mainstream and is now practiced by large universities and institutes across the globe. Into this dynamic of the rapidly changing world of translational medical research this book sets the life of one of the discipline’s most influential practitioners, Anthony Cerami. His work spans more than five decades and culminated in the discovery, invention and development of diagnostics and therapeutics used daily by millions of people. Students in molecular medicine and investigators pursuing basic science in the hope of improving human health will find inspiration in examining the sacrifices and achievements of Cerami’s career in translational medicine. During his three decades at Rockefeller University his cross-disciplinary and laboratory-without-wall approach established ‘rational drug design’ as the most effective means of advancing the fields of parasitology, hematology, immunology, metabolism, therapeutics and molecular medicine. Cerami’s story and that of the evolution of translation are intimately entwined: the contours of Cerami’s career shaped by developments in translation, and in exchange, the field itself molded by Cerami’s work. To understand one is to understand the other. By examining the life of this often overlooked biochemist it is possible to intimately focus on the ideas and thought processes of a scientist who has helped to define the great acceleration in translational research over the past half century – research that, knowingly or otherwise, has most likely affected the life of almost everyone on the planet. We also gain a better understanding of the febrile creative atmosphere that percolated through the laboratories leading the way in translational medicine, and gain insight into the art, science, successes, failures and providence that underlie major scientific breakthroughs. Anybody interested in the questions of where modern medicines come from, how health outcomes around the globe are affected by research and imagination, and where the future of drug discovery is leading, will be rewarded by exploring Cerami’s life in translation. This book is not restricted to those with a professional interest in science, because anyone dedicated to living a life of creativity and discovery will be rewarded by reading this book. In many respects, Cerami’s life reflects the modern metaphor of the ‘American dream’ with his journey from humble beginnings on a chicken farm in rural New Jersey, to occupying a place in the highest echelons of the US scientific establishment. His journey in translational medicine was propelled forward by two obsessions; the idea that he could help people who were sick, and the excitement of discovery. In following his two great passions, he trained a generation of specialists in translational medicine that continue to transform our understanding of, and treatments for, human disease. Anthony Cerami’s work has shown how science has become an important force for social change by laying the foundations of modern translational medicine. Trade Review“Tony Cerami has been one of the most creative exponents of translational medicine. He has combined innovative science with novel approaches to experimental medicine to better understand the basis of disease and how therapies work and his insights into diseases such as sleeping sickness and diabetes have had a wide impact on medicine.” -- Sir John Bell * Regius Chair of Medicine at the University of Oxford *“Translation of scientific discoveries into useful applications is central to modern biomedicine, leading to the development of new and more effective ways of treating human disease. Anthony Cerami has played a critical role in establishing and promoting translation through a half-century career in laboratory research aimed at new methodologies and rational drug design for improved diagnosis and therapies. Read this book to follow his life from a chicken farm to respected biomedical scientist, and to learn how translation has evolved in recent decades and has brought benefit to humankind through better treatment of disease.” -- Sir Paul Nurse * Director of the Francis Crick Institute *"This is a fascinating profile of a remarkable man who throughout his life has made key contributions to the warp and the weft of translational medicine. His work on cachectin/TNF alone has had a huge impact, contributing both to transformational treatments for inflammatory diseases and to the reshaping of the pharmaceutical industry.” -- Sir Greg Winter * Trinity College Cambridge *“Tony Cerami is one of the great unsung heroes of biomedical research. His discoveries had a direct impact on the development of cytokine inhibitors as a strategy to treat inflammatory diseases. Conrad Keating has done a great job in telling Tony’s story and conveying his huge contribution to translational medicine.” -- Luke O'Neill * Trinity College Dublin *"A 'smooth' read that describe[s] [Anthony Cerami's] scientific successes as well as his scientific and personal failures. After reading this book, it is clear to me that most scientists would do well to emulate the successes of Dr. Cerami but to also avoid his failures. Nonetheless, as clearly covered in this book, his career was exciting and constantly challenging....This will make a good summer beach read." -- Howard Young, Ph.D., * Past President International Society of Interferon and Cytokine Research *Table of ContentsForeword Introduction 1. Hard Work 2. The Rockefeller Effect 3. The Shaping of a Scientific Mind 4. The Rockefeller University and the Broad Horizon 5. Diabetes: The Creation of the Hemoglobin A1c Test 6. Glucose, Aging, and the Cross-linking of Biology and Business 7. The Conceptual Breakthrough 8. Cachectin—Tumour Necrosis Factor 9. Leaving The Rockefeller University: The End of the Dream 10. Philanthropy Goes Awry 11. Translation in Transition 12. Anti-TNF Therapy: Changing the Pharmaceutical Landscape 13. Taking on Big Pharma Acknowledgments Notes Index
£34.20
Springer Nature Switzerland AG Outbreak in the Village: A Family Doctor's
Book SynopsisOutbreak in the Village is a fascinating account of the personal and professional journey of Dr. Doug Jenkinson, physician and researcher. Over the course of four decades in practice, Jenkinson traces the reemergence of whooping cough in the developed world, using his practice in the idyllic English countryside as a clinical control group. Keeping meticulous notes and indulging an itch to investigate, he explores one of history's most enigmatic and pervasive diseases. Jenkinson relates the tale of his life's work amid winsome anecdotes, relevant history, and practical advice. Told in an amiable, engaging voice with an expert balance of levity and earnestness, this story will charm casual readers interested in medical history and memoir, as well as doctors and researchers who identify with the experiences and may benefit from the research and techniques employed. Readers will find themselves in the examination room beside Jenkinson as the investigation unfolds, learning about the nature of the illness and the sweeping detrimental effects of an anti-vaccination campaign. An intriguing memoir about a mysterious illness, a public health failure, and one doctor's quest for clarity, Outbreak in the Village is a tale of perseverance and objectivity sure to delight and inform.Table of Contents Introduction From Africa to England The children’s clinic at Keyworth Whooping cough vaccine 1977–9. The first outbreak of whooping cough Does the vaccine work? 1981. Whooping cough vaccine is very rarely harmful 1981–3. The second outbreak. How many cases are there really? 1985–7. The third outbreak. The search for subclinical infection 1987. Does the effectiveness of the vaccine wear off? 1988. Trying to raise the uptake of pertussis vaccine 1989–91. The fourth outbreak. The natural history of whooping cough 1990s. Whooping cough fades away but new diagnostic tests emerge 2000. Whoopingcough.net. Overcoming diagnostic paralysis The early noughties. The new tests aid the re-discovery of whooping cough Late noughties. ‘Resurgence’ of whooping cough in the USA and Australia puts the UK on alert 2012. Whooping cough diagnoses peak in the UK but remain unchanged in Keyworth What lies ahead? Epilogue About Bordetella bacteriaAge incidence changes in Keyworth whooping cough patients A critical look at recent pertussis statistics in England
£23.74
Springer Nature Switzerland AG Cancer Metastasis Through the Lymphovascular
Book SynopsisThis textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions. Table of Contents
£123.49
Springer International Publishing AG The Marathon of the Messenger: A History of
Book SynopsisThe Covid-19 pandemic changed the world. Indeed a real race took place worldwide between SARS-CoV-2 on the one hand and researchers on the other – especially those specializing in messenger RNA vaccines. Four years after its emergence, the pandemic is not over, but some decisive battles have been won, thanks to the great success of mRNA vaccines. The Marathon of The Messenger presents the history of these mRNA vaccines, combining a scientific background with historical and economic perspectives. It appears that an important page in the history of these new vaccines was written in Europe, thanks to the crucial work of German and French scientists; this effort began in 1993 and continues to this day. In the face of a prevailing single-mindedness, these researchers pushed through a new therapeutic concept and defined the biotechnological keys that would open the way to the production of therapeutic messenger RNA in the fight against cancer and viral infections. Written for a broad audience and accompanied by humorous cartoons, this book will appeal to anyone looking for scientific and historical answers about mRNA vaccines. Readers will discover not only the technical and scientific knowledge of how these vaccines work, but also the economic levers that were necessary to create this technology. This book has been written in collaboration with Dr. Steve Pascolo, former director of CureVac, and the RNA messenger expert Professor Chantal Pichon. It also features a preface by Dr. Pierre Meulien, former director of the European Union public-private partnership Innovative Medicines Initiative (IMI).Table of ContentsChapter 1. Introduction: The Marathon of the Messenger RNA.- Part I. Messenger RNA, an essential role and challenge.- Chapter 2. A short history of vaccination.- Chapter 3. From DNA to RNA.- Chapter 4. Messenger RNA (mRNA): from transcription to protein translation.- Chapter 5. The mechanism of viral infection.- Chapter 6. The immune response.- Part II. From preliminary studies to clinical trials.- Chapter 7. Promising studies in the 1990s.- Chapter 8. The use of mRNA - the initial technical obstacles.- Chapter 9. The birth of CureVac: the era of the pioneers.- Chapter 10. Solutions for mRNA optimization.- Chapter 11. Modified and unmodified mRNA: for what purpose?.- Chapter 12. Experiments and clinical trials conducted: the power of therapeutic mRNA.- Chapter 13. Experiments and clinical trials against infectious diseases.- Chapter 14. Experiments and clinical trials against cancer.- Chapter 15. Experiments and clinical trials carried out in other therapeutic fields.- Chapter 16. Modified mRNA versus unmodified mRNA: not just a scientific issue.- Part III. The triumph of messenger RNA.- Chapter 17. A very progressive diffusion in scientific circles.- Chapter 18. The development of future biotechs in the 2010s.- Chapter 19. The importance of intellectual property and patents.- Chapter 20. 2020: the triumph of anti-Covid mRNA vaccines.- Chapter 21. mRNA, a technology of the future
£26.99
Springer International Publishing AG Alternate Programmed Cell Death Signaling in
Book SynopsisThis volume provides a comprehensive review of programmed cell death pathways and their fundamental role in antiviral host defense. The book deep-dives into the molecular functions and regulation of necroptosis and discusses how viruses induce and manipulate this potent innate cellular sensing system. Initially, understanding of necroptosis emerged from studies on tumor necrosis factor (TNF) signaling that showed the key role of receptor interacting protein kinase 1 (RIPK1) in the activation of receptor interacting protein kinase 3 (RIPK3) which then phosphorylates mixed lineage kinase domain like pseudokinase (MLKL) to execute cells via plasma membrane leakage of cytosolic contents. Since its discovery, multiple facets of the RIPK3-dependent necroptotic machinery have evolved where the requirements for execution of death varies depending on the stimulus. Virus-induced necroptosis was discovered over 10 years ago in studies on murine cytomegalovirus (MCMV) where a virus-encoded inhibitor was shown to prevent the recruitment of RIPK3 (RIP3). This transformative evidence identified a novel pathway acting independent of TNF, interferon or RIPK1 that can stop virus from infecting its natural mouse host by killing off infected cells to halt replication. Over the past decade influenza A virus (IAV), herpes simplex virus (HSV) and poxvirus vaccinia (VACV) have all been shown to trigger the pathway. Herpesviruses and poxviruses also encode inhibitors of caspase-8 whose elaboration unleashes the necroptosis pathway. IAV and other RNA viruses do not encode programmed cell death inhibitors. RIPK3 is also known to induce apoptosis by recruiting RIPK1 as shown nearly a decade ago and this dual apoptosis/necroptosis induction occurs naturally during influenza A virus infection. RIPK3 is also able to induce an inflammatory response independently of programmed cell death that can predominate to drive inflammatory disease outcomes. This volume is a must-read for researchers and advanced students in immunology and virology.Table of ContentsProgrammed Necrosis in Host Defense.- ZBP1/DAI-dependent Cell Death Pathways in Influenza A Virus Immunity and Pathogenesis.- Pyroptosis in Antiviral Immunity.- Manipulation of Host Cell Death Pathways by Herpes Simplex Virus.- Subversion of Programed Cell Death by Poxviruses.- Cell Killing by Reovirus: Mechanisms and Consequences.- Outcomes of RIP kinase signaling during neuroinvasive viral infection.
£107.99
Springer Breast Cancer Immunotherapy
Book SynopsisPart I: Immunity and Cancer.- The Functional Cancer Immunity Cycle.- Rationale for Immunotherapy for Breast Cancer.- Tumor-Infiltrating Lymphocytes as a Prognostic and Predictive Marker in Breast Cancer.- Part II: Therapeutic Interventions for Breast Cancer.- Therapeutic Interventions for Breast Cancer: Advanced Breast Cancer.- Immunotherapy in Early Triple-Negative Breast Cancer.- Part III: Vaccines.- Peptide Vaccines in Breast Cancer.- mRNA Vaccination for Breast Cancer.- Part IV: Emerging Therapeutic Strategies.- Radiation and Immunotherapy in Breast Cancer.- The Clinical Development of Immune Checkpoint Inhibitors in Combination with Targeted Therapy in Breast Cancer.- Targeting the STING Pathway in Breast Cancer.- Immunotherapy Combinations and Dual Checkpoint Blockade.- CAR T Cell Strategies for Metastatic Breast Cancer.- Part V: Emerging Biomarkers of Response to Immunotherapy.- Tumor Characteristics.- Host Characteristics in Breast Cancer.
£71.99
Springer Fachmedien Wiesbaden Der Experimentator: Immunologie
Book SynopsisLieber EXPERIMENTATOR,seit der Erstauflage im Jahr 2004 ist nun die 4. Auflage des Immuno-EXPERIMENTATORS erschienen. Das Werk präsentiert die methodische Vielfalt der Immunologie, indem es die gängigen Methoden auf einfache Weise erklärt und auf Vor- und Nachteile sowie auf kritische Punkte eingeht.Auf eine Einführung über Antikörper, deren Funktion und Quelle in vivo sowie über deren Anwendung als immunologisches Tool folgen u.a. Methoden wie die Durchflusscytometrie, Immuno-Blot, ELISA und ähnliche Immunoassays bis hin zu Zellseparationstechniken und in-situ-Immunlokalisation. Als zusätzliches Schmankerl wird dem Leser die Möglichkeit geboten, Einblicke in die Untiefen der Biostatistik zu nehmen.Der EXPERIMENTATOR-Immunologie richtet sich an Technische Assistenten, Laboranten, Diplomanden und Doktoranden und natürlich an alle, die an der Immunologie interessiert sind. Informative Abbildungen, Hintergrundinformationen, ein Glossar sowie Tabellen mit allen Cytokinen/Chemokinen und der aktuellen CD-Nomenklatur runden das Werk ab und machen es zu einem nützlichen Begleiter im Laboralltag.In der 4. Auflage erwartet den EXPERIMENTATOR u.a. Neues aus der Hochdurchsatztechnologie (Antikörper- und Tissue-Microarray) sowie ein Überblick über den therapeutischen Einsatz von Immunzellen. Ein besonderer Fokus wird hier auf Dendritische Zellen gelegt. Selbstverständlich haben die Autoren auch die CD-Nomenklatur sowie die Cytokin- und Chemokintabelle auf den aktuellen Stand gebracht.Trade ReviewAus den Rezensionen: “… Dies geschieht in einem fröhlichfrechen und gar amüsanten Schreibstil, der selbst Exkurse in physikalische und chemische Grundlagen interessant gestaltet. Zahlreiche Abbildungen veranschaulichen die Methoden und übersichtliche Tabellen geben einen Einblick in mögliche Versuchsprotokolle ...“ (Maria Embgenbroich, in: BIOspektrum, Jg. 20, Heft 7, 2014)Table of ContentsVorwort Kapitel 1: Antikörper 1.1 Des Antikörpers Eigenschaften 1.2 Herstellung von Antikörpern 1.3 Reinigung von Antikörpern 1.4 Chemische Kopplung und Markierung von Antikörpern Kapitel 2: Zellseparation 2.1 Trennung nach Zellgröße und Zelldichte - Zentrifugationstechniken 2.2 Trennung nach zellspezifischen Oberflächenmolekülen Kapitel 3: Durchflusscytometrie 3.1 Wie funktioniert das eigentlich? 3.2 Fluoreszenzen 3.3 Probenvorbereitung 3.4 Inbetriebnahme des Durchflusscytometers 3.5 Kompensation und Messung 3.6 Auswertung 3.7 Modelle und Ausstattungen Kapitel 4: Quantitative Immunoassays 4.1 Assaykonzepte 4.2 Radioimmunoassay (RIA) 4.3 Enzyme-linked Immunosorbent Assay (ELISA) 4.4 ELISPOT-Assay 4.5 Partikel-Immunoassay (PIA) 4.6 Verstärkersysteme Kapitel 5: Western-Blot 5.1 Probenvorbereitung 5.2 Auftrennung eines Proteingemisches mittels Gelektrophorese 5.3 Transfer der Proteine auf eine Membran (Blot) 5.4 Proteindetektion 5.5 Dot- und Slot-Blot Kapitel 6: in-situ Immunlokalisation 6.1 Untersuchung von Zellsuspensionen 6.2 Untersuchung von Geweben 6.3 Immunelektronenmikroskopische Untersuchung von Geweben Kapitel 7: Immunpräzipitation 7.1 Die Klassiker 7.2 Immunpräzipitation "heute" Kapitel 8: Die Zelle: leben, fressen, sterben 8.1 Zellviabilitätsbestimmung 8.2 Zellproliferation 8.3 Phagocytose Assays 8.4 Zellvermittelte Cytotoxizität 8.5 Apoptose Assays Kapitel 9: Spezielle Immunoassays 9.1 Blutgruppenbestimmung 9.2 HLA-Typisierung 9.3 Lymphoblastentransformation Kapitel 10: Ein kurzer Ausflug in die ungeliebte Welt der Statistik 10.1 Deskriptive Statistik 10.2 Prüfstatistik Kapitel 11: Naturwissenschaft vs. Übernatürliches Kapitel 12: Die Lieferanten - unsere Partner? 12.1 Lieferantenverzeichnis (alphabetisch) 12.2 Lieferanten geordnet nach Schwerpunkten Anhang: CD-Antigene Glossar Register
£28.49
Springer Fachmedien Wiesbaden Janeway Immunologie
Book SynopsisJetzt wieder auf dem neuesten Stand: DIE Einführung in die Immunologie für Studierende der Biowissenschaften und der MedizinDer Janeway, das bewährte und viel gelobte Standardlehrbuch der Immunologie, liegt nun erneut in einer vollständig überarbeiteten und aktualisierten Fassung vor. Das Werk führt den Leser in gewohnter Souveränität durch alle Aspekte des Immunsystems – vom ersten Einsatz der angeborenen Immunität bis zur Erzeugung der adaptiven Immunantwort, von den vielfältigen klinischen Konsequenzen normaler und pathologischer immunologischer Reaktionen bis zur Evolution des Immunsystems.In der 9. Auflage sind unter anderem neue Erkenntnisse zur modularen Immunantwort, zur Klassenwechsel-Rekombination, zur Vielfalt der CD4-T-Zellen, zu Chemokin-Netzwerken, zur Umgehung der Immunabwehr durch Pathogene und zur Immuntherapie von Krebs integriert. Zahlreiche neue Abbildungen veranschaulichen die im Text erläuterten Prozesse und Konzepte. Der umfangreiche Anhang zu den Methoden der Immunologie ist um etliche neue Techniken erweitert worden. Zudem wurden die Verständnisfragen an den Kapitelenden komplett überarbeitet. Das in zahlreiche Sprachen übersetzte Werk besticht durch seine Aktualität, seine konzeptionelle Geschlossenheit und seine ansprechende Illustration. Es bleibt damit in diesem unverändert rasant fortschreitenden Fachgebiet ein hochaktueller und verlässlicher Begleiter.Stimmen zu früheren Auflagen:Dieses Buch bringt Studenten und Wissenschaftlern die Immunologie aktuell und in hervorragender Weise näher. Prof. Dr. Nikolaus Müller-Lantzsch, Universitätskliniken HomburgDie neue Auflage ist kaum noch zu schlagen. Prof. Dr. Stefan H.E. Kaufmann, Max-Planck-Institut für Infektionsbiologie, BerlinHervorragend. Dieses Lehrbuch genügt sämtlichen Ansprüchen! Prof. Dr. Andreas Dotzauer, Uni BremenDas Buch besticht durch die hervorragende Vermittlung von Grundlagenwissen, das es in weiterer Folge ermöglicht, auch die komplexen Zusammenhänge bei klinisch-immunologischen Fragestellungen zu verstehen. Prof. Dr. Wolfgang Sipos, Medizinische Universitätsklinik WienDie auf das wesentliche reduzierten graphischen Darstellungen haben einen besonderen didaktischen Wert, vor allem angesichts der Komplexität dieses Fachgebiets. Prof. Dr. Arne Skerra, TU MünchenUnter den Immunologie-Lehrbüchern nimmt dieses sicher heute den vorderen Rang ein. Es macht Vergnügen, sich von ihm bilden zu lassen. BiospektrumAlles in allem ein wunderbar gestaltetes, umfassendes Lehrbuch, dessen Schwerpunkt deutlich auf der Erklärung grundlegender Mechanismen der Immunabwehr liegt. Naturwissenschaftliche RundschauDas Buch ist didaktisch hervorragend, vor allem auch in den Abbildungen, und bietet am Ende der Kapitel prägnante Zusammenfassungen, Fragen zum Überprüfen des Gelernten und Hinweise auf Originalarbeiten. Pharmazie in unserer Zeit Uneingeschränkt empfehlenswert; es eignet sich besonders für Biologiestudenten zur Prüfungsvorbereitung, für Mediziner als Nachschlagewerk, aber auch für Studenten und Dozenten anderer Fächer. Chirurgische PraxisDieses packende moderne Lehrbuch [bietet] jungen Biologen und Medizinern die gegenwärtig beste Möglichkeit, die Mechanismen des Immunsystems in ihrem evolutionären und funktionellen Kontext und medizinischen Bezug kennen zu lernen und vielleicht für ihre eigene zukünftige Tätigkeit zu entdecken. Prof. Dr. Klaus Rajewsky im Vorwort zur 5. AuflageTrade Review“... Die einzelnen Kapitel bieten am Ende eine Zusammenfassung, die eine etwas konzentriertere Darstellung des jeweiligen und immer sehr detailliert dargestellten Themas ermöglicht. Besonders für Studierende sind die der Zusammenfassung nachgestellten Aufgaben in Form von MultipleChoice-Fragen sicher eine große Hilfe. Zusammengefasst handelt es sich um ein traditionsreiches Lehrbuch der Immunologie, das als „State of the Art“ angesehen werden kann.” (Dr. med. Peter Holzhauer, in: Deutsche Zeitschrift für Onkologie, Heft 3, 2020)“Der Janeway ist in seiner neuen Auflage so aktuell, wie ein derart umfangreiches Lehrbuch überhaupt sein kann. Die Übersetzung ins Deutsche ist dabei durchweg gelungen. Die Zusammenfassungen und die Fragen zu den einzelnen Kapiteln sind für Studierende und Dozent(inn)en besonders hilfreich. Bei der Vorbereitung standardisierter Immunologie-Prüfungen kann man sich daran gut orientieren.“ (BIOspektrum, Oktober 2010)“Alles in allem ein wunderbar gestaltetes, umfassendes Lehrbuch, dessen Schwerpunkt deutlich auf der Erklärung grundlegender Mechanismen der Immunabwehr liegt.“ (Naturwissenschaftliche Rundschau, Februar 2010)“Das Buch (...) gibt als Nachschlagewerk eine schnelle und präzise Antwort auf Fragen, zu denen man vielleicht sein Wissen punktuell oder generell verbessern möchte. Das Buch ist didaktisch hervorragend, vor allem auch in den Abbildungen, und bietet am Ende der Kapitel prägnante Zusammenfassungen, Fragen zum Überprüfen des Gelernten und Hinweise auf Originalarbeiten.“ (Pharmazie in unserer Zeit, Januar 2010)Zitate übersetzt aus dem Englischen:“Eine der herausragendsten Einführungen in die Immunologie ... Das Buch ist leicht zu lesen und zu verstehen, und jedes Thema ist umfassend abgehandelt ... Kurz zusammengefasst: Dieses Buch ist ein Muss.“ (World Allergy Organization News and Notes)“Eine anschauliche, lebendige und verlässliche Einführung in das gesamte Gebiet der Immunbiologie.“ (Cell)“So aktuell, wie ein Lehrbuch nur sein kann.“ (The New England Journal of Medicine)„Dieses Buch setzt eindeutig neue Maßstäbe.“ (Immunology Today)Table of ContentsTeil I Einführung in die Immunologie und die angeborene Immunität.- 1 Grundbegriffe der Immunologie.- 2 Die angeborene Immunität.- 3 Die induzierten Reaktionen der angeborenen Immunität.- Teil II Die Erkennung von Antigenen.- 4 Antigenerkennung durch B-Zell- und T-Zell-Rezeptoren.- 5 Die Entstehung von Antigenrezeptoren in Lymphocyten.- 6 Wie Antigene den T-Lymphocyten präsentiert werden.- Teil III Die Entstehung des Rezeptorrepertoires von reifen Lymphocyten.- 7 Signalgebung durch Rezeptoren des Immunsystems.- 8 Die Entwicklung der B- und T-Lymphocyten.- Teil IV Die adaptive Immunantwort.- 9 Die T-Zell-vermittelte Immunität.- 10 Die humorale Immunantwort.- 11 Die Dynamik der angeborenen und adaptiven Immunantwort.- 12 Das mucosale Immunsystem.- Teil V Das Immunsystem bei Gesundheit und Krankheit.- 13 Das Versagen der Immunantwort.- 14 Allergien und allergische Erkrankungen.- 15 Autoimmunität und Transplantation.- 16 Die gezielte Beeinflussung der Immunantwort.
£79.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Braun-Falco´s Dermatology
Book SynopsisThe standard textbook of Dermatology and Allergy in new edition! The 4th edition of the "Braun-Falco Textbook", an international standard text of dermatology, allergy and sexually transmitted disorders has been thoroughly rewritten and reedited and offers a comprehensive state-of-the-art review of the entire field for clinicians in hospital and private practice. The editors assembled an expert team of authors with outstanding international reputation who present a concise overview of the complete spectrum of dermatology and its groundbreaking progress with particular emphasis on aspects of practical care within the specialty. The treatment recommendations are based on current international guidelines and standards of care, and pay special attention to latest therapeutic progress as well as recent pathophysiological concepts. A special emphasis has been put on a unique array of high quality figures and a clear, easily understandable structure of the respective chapters. Besides the printed version, the new edition is available as a digital version. New aspects of the 4th edition that reflect the tremendous and rapid progress of dermatology include an up to date clinical classification of dermatoses, current guidelines and therapeutic concepts in inflammatory and neoplastic diseases, and dermatological aspects of the new Covid-19 infection. “Braun-Falco`s Dermatology” is a must for specialists and trainees in dermatology, and of great value for all physicians who encounter skin diseases in general. Table of ContentsBasic Principles: .- Introduction to the Skin and Dermatology.- Immunology.- Genetics.- Diagnostic Tools: Dermatopathology.- Dermatoscopy.- Ultrasonography of Skin and Lymphnodes.- Other Skin Imaging Technologies.- Infectious Diseases: Viruses: .- Human Papilloma Virus Infections.- Human Herpes Viruses.- Other Viral Infections of the Skin.- Infectious Diseases: Bacteria: Staphylococcal and Streptococcal Diseases of the Skin.- Other Bacterial Infections.- Lyme Borreliosis and Other Nonvenereal Spirochetal Infections.- Mycobacterial Infections of the Skin.- Infectious Diseases: Fungi: Fungal Infections.- Infectious Diseases: Sexually Transmitted Diseases: Sexually Transmitted Diseases Introduction.- Gonorrhea and Urethritis.- Syphilis.- Other Venereal Infections.- HIV/AIDS.- Infectious Diseases: Parasitic Infections: Protozoal Infections.- Diseases Caused by Arthropods.- Diseases Caused by Worms.- Allergy and Intolerance Reactions: Basics in Allergology and Hypersensitivity Reactions.- Immediate-type Allergy: Rhinoconjunctivitis, Asthma, Anaphylaxis.- Food Allergy.- Bee and Wasp Venom Allergy.- Urticaria and Angioedema.- Contact Dermatitis.- Occupational Dermatoses.- Atopic Dermatitis.- Other Types of Dermatitis.- Pruritus and Prurigo.- Drug Hypersensitivity: Cutaneous Adverse Drug Reactions.- Severe Cutaneous Adverse Reactions.- Skin Changes Induced by Alcohol, Drug-toxicomania and Smoking.- Inflammatory Diseases: Papulosquamous Disorders.- Psoriasis.- Papular and Lichenoid Diseases.- Pustular Diseases.- Granulomatous Diseases.- Diseases with Eosinophilia.- Environmental Diseases: Photodermatoses.- Disorders Caused by Physical and Chemical Damage.- Diseases Caused by Ionizing Radiation.- Aquatic-acquired Skin Diseases.- Bullous Disorders: Epidermolysis Bullosa.- Autoimmune Bullous Diseases.- Connective Tissue Diseases: Connective Tissue Diseases: Introduction.- Hereditary Disorders of Collagen and Elastin.- Acquired Disorders of Elastin and Collagen.- Scleroderma.- Lupus Erythematosus.- Dermatomyositis and other Autoimmune Disorders.- Hereditary Disorders: Malformations and Genodermatoses.- Genodermatoses II.- Mosaicism and Epidermal Nevi.- Malformations of Vessels, Fat, and Connective Tissue.- Ichthyoses.- Disorders of Keratinization.- Heriditary Immunodeficiency Diseases.- Vascular Diseases: Functional Angiopathies.- Vasculitis and Vasculopathies.- Peripheral Occlusive Arterial Disease.- Capillary Nevi and Other Vascular Malformations.- Diseases of Veins.- Diseases of Lymphatics.- Disorders of Hemostasis.- Pigmentary Diseases: Disorders of Melanin Pigmentation.- Dyschromias.- Diseases of Adnexal Structures: Acne and Rosacea.- Diseases of Sweat Glands.- Diseases of Hair.- Diseases of Nails.- Regional and Special Disorders: Diseases of the Lips and Mouth.- Inflammatory Diseases of Cartilage.- Diseases of Fat.- Diseases of the Female Genitalia.- Diseases of the Male Genitalia.- Proctology.- Disorders of Pregnancy.- Neonatal Dermatology.- Andrology.- Psychodermatological Diseases.- Sports Dermatology.- Diseases in Skin of Color.- Metabolic Diseases: Disorders of Lipid Metabolism.- Disorders of Purine, Sphingolipid, and Amino Acid Metabolism.- Gammopathies.- Amyloidoses and Hyalinoses.- Mucinoses.- Porphyrias.- Cutaneous Calcification.- Diseases of Mineral Metabolism.- Nutritional Diseases.- Endocrine Diseases.- Tumors: Cysts.- Benign Epithelial Tumors.- Basal Cell Carcinoma.- Malignant Epithelial Tumors.- Adnexal Tumors.- Melanotic Spots and Melanocytic Nevi.- Melanoma.- Mesenchymal and Neural Tumors.- Vascular Tumors.- Pseudolymphomas.- Cutaneous Lymphomas.- Cutaneous Aspects of Leukemia.- Mastocytoses.- Histiocytoses.- Paraneoplastic Disorders.- Cancer-associated Genodermatoses.- Therapy: Topical Therapy.- Systemic Therapy.- Physical Therapy: Light.- Physical Therapy: Cold, Heat.- Lasers and Photodynamic Therapy.- Therapy with Ionizing Radiation.- Dermatological Surgery.- Scar Therapy.- Wound Healing.- Aesthetic Dermatology.
£269.99
Springer Fachmedien Wiesbaden Vorratsschädlinge und Hausungeziefer: Bestimmungstabellen für Mitteleuropa für eine natur- und umweltbewusste Bekämpfung
Book SynopsisEine natur- und umweltbewusste Bekämpfung von Haus- und Vorratsschädlingen muss artspezifisch erfolgen. Nur so kann man Gifte gezielt einsetzen bzw. vermeiden und durch biologische Bekämpfungs- oder Vorbeugemaßnahmen ersetzen. Anhand dichotomer Schlüssel und zahlreicher Zeichnungen spezieller Merkmale lassen sich mit diesem Buch alle in Mitteleuropa vorkommenden Vorrats- und Materialschädlinge, Hausungeziefer sowie Ektoparasiten von Mensch und Haustier bis zur Art bestimmen. Die 9. Auflage wurde auf Fehler durchgesehen und korrigiert. Table of Contents
£66.49
Springer Spektrum Grundwissen Immunologie
Book SynopsisMeilensteine der Immunologie oder eine etwas andere Einführung.- DAS FUNKTIONIERENDE IMMUNSYSTEM.- 1 Was gehört zum Immunsystem?.- 2 Wie erkennen die Immunzellen ein Antigen?.- 3 Was versteht man unter einer klonalen Antwort?.- 4 Wie verarbeiten die Immunzellen die Informationen?.- 5 Welche Konsequenzen hat die Aktivierung der Immunzellen?.- 6 Wie kommt eine Immunreaktion in Gang?.- 7 Zurück in die Homöostase.- 8 Wie funktioniert das Immungedächtnis?.- 9 Wie vereinbart sich ein breites, zufällig entstandenes Antigenrezeptor-Repertoire mit immunologischer Selbsttoleranz?.- 10 Wie wird eine Immunantwort koordiniert?.- 11 Was passiert an den Grenzflächen? WICHTIGE AUFGABEN DES IMMUNSYSTEMS.- 12 Wie schützt das Immunsystem bei Infektionen?.- 13 Immunsystem gegen Tumoren.- 14 Von der Wiege bis zur Bahre.- 15 Zwischenbilanz: Die Funktionen des Immunsystems in der Übersicht.- KRANKHEITEN DURCH FEHLFUNKTIONEN DES IMMUNSYSTEMS.- 16&
£31.34
Springer Fachmedien Wiesbaden Lebensmittel und das Immunsystem: Molekulare Wirkmechanismen und deren Einfluss auf die Gesundheit
Book SynopsisWie beeinflussen Lebensmittelkomponenten und -inhaltsstoffe die Immunantwort? Welche Rolle spielt das Mikrobiom des Darms bei der Entstehung von Erkrankungen? Kann die Funktion des Immunsystems durch eine bestimmte Ernährungsweise positiv stimuliert werden? Dieses farbige, gut zu lesende Lehrbuch diskutiert auf einem aktuellen Niveau die Einflüsse von Lebensmittelinhaltsstoffen auf die biochemisch-, zellulär-regulatorischen und genetischen Abläufe der gesamten Immunabwehr. Schwierige Sachverhalte werden durch Leitfragen und Definitionsboxen verständlich vermittelt. Exemplarisch dargestellte Krankheitsbilder zeigen Anwendungsmöglichkeiten für funktionale Lebensmittel auf. Exkurse geben technologische, rechtliche und ethische Einblicke in die Entwicklung von Supplementen, Nutraceuticals und Healthfood.Pointierte Zusammenfassungen, Wirkstoffauflistungen und ein Fachbegriffglossar zeichnen dieses Lehrbuch auch als Referenz- und Nachschlagewerk aus. Besonders hervorzuheben sind zudem über 30 kurze Lehrvideos, in denen zelluläre und molekulare Interaktionen animiert erläutert werden. Dieses Lehrbuch spricht alle Studierenden und Berufstätigen an, die sich mit Ernährung und Gesundheit beschäftigen.Table of ContentsGrundlagen: Grundprinzipien des Immunsystems.- Die Immunbarriere: Einfluss von Lebensmittelkomponenten auf die Darmbarriere.- Die Abwehrreaktion des angeborenen Immunsystems: Einflüsse von Lebensmittelkomponenten auf die frühe Phase der Immunantwort.- Die adaptive Abwehrreaktion: physiologisches und pathologisches Stimulationspotenzial von Lebensmittelkomponenten in der antigenspezifischen Immunantwort.- Einfluss von Mikro- und Makronährstoffen auf die klonale Phase der adaptiven Immunantwort.- Begrenzung und Beendigung der Immunantwort: Einflüsse von Lebensmittelkomponenten auf die Herabregulation und Beendigung der immunologischen Abwehrreaktion.- Immungenetik: Einflüsse von Lebensmittelkomponenten auf die Expression immunrelevanter Gene.- Antworten zu den Fragen.- Anhang.- Glossar.- Index.
£37.99
Spektrum Akademischer Verlag Janeway Immunologie
Book Synopsis
£6.95
Springer Weißbuch Allergie in Deutschland
Book Synopsis
£36.09
New India Publishing Agency Livestock Survival and Management During
Book Synopsis
£128.48
