Hereditary diseases and disorders Books

Book SynopsisA practical, illustrated, quick reference guide to clinical virology. It brings together the essentials of the subject in an informative style, describing in turn the clinical features, the symptoms and signs of each of the viral diseases, as well as summarising the epidemiology, laboratory diagnosis and therapy in each case.Table of ContentsContributors ix Preface xi Preface to 1st Edition xiii Abbreviations xv References for Further Reading xvii 1 Classification and Nomenclature of Human and Animal Viruses 1Y. Ghendon 2 Viruses and Disease 7G. Haukenes and J. R. Pattison 3 Laboratory Diagnosis of Virus Infections 15G. Haukenes and R. J. Whitley 4 Antiviral Drugs 21J. S. Oxford and R. J. Whitley 5 Virus Vaccines 37L. R. Haaheim and J. R. Pattison 6 Enteroviruses: Polioviruses, Coxsackieviruses, Echoviruses and Newer Enteroviruses 45A. L. Bruu 7 Polioviruses 47A. L. Bruu 8 Coxsackieviruses, Echoviruses and Enteroviruses 29–34 and 68–71 55A. L. Bruu 9 Rhinoviruses and Coronaviruses 61I. Ørstavik 10 Influenzaviruses 67L. R. Haaheim 11 Parainfluenzaviruses 75A. B. Dalen 12 Mumps Virus 81B. Bjorvatn and G. Haukenes 13 Respiratory Syncytial Virus (RSV) 89G. Ånestad 14 Measles Virus 97N. A. Halsey 15 Rubella Virus 105G. Haukenes 16 Adenoviruses 113I. Ørstavik and D. Wiger 17 Rotaviruses 121I. Ørstavik and E. Kjeldsberg 18 Herpes Simplex Virus (HSV1 and HSV2) 127E. Tjøtta and G. Hoddevik 19 Varicella-Zoster Virus (VZV)—Varicella 137A. Winsnes and R. Winsnes 20 Varicella-Zoster Virus (VZV)—Zoster 145A. Winsnes and R. Winsnes 21 Cytomegalovirus (CMV) 149A. B. Dalen 22 Epstein–Barr Virus (EBV) 157E. Tjøtta 23 Human Herpesvirus 6 (HHV-6) 167J. A. McCullers 24 Hepatitis A Virus 173M. Degré 25 Hepatitis B Virus 179G. L. Davis 26 Hepatitis C Virus 185G. L. Davis 27 Hepatitis D Virus 191G. L. Davis 28 Hepatitis E Virus 195M. Degré 29 Emerging Hepatitis Viruses 201G. L. Davis 30 Parvovirus B19 203J. R. Pattison 31 Retroviruses 209A. B. Dalen 32 Human Immunodeficiency Virus (HIV) 213B. Asjö 33 Human T-Cell Lymphotropic Virus Type I and II 221R. J. Whitley and G. Shaw 34 Tick-borne Encephalitis (TBE) Virus 227T. Traavik 35 Hantaviruses—HFRS and HPS 235D. Wiger 36 Haemorrhagic Fever Viruses 241G. Haukenes 37 Rabies Virus 245B. Bjorvatn and G. Haukenes 38 Human Papillomavirus (HPV) 251T. Traavik 39 Human Polyomaviruses 259T. Traavik 40 Slow Viruses 263G. Haukenes 41 Poxviruses 267G. Haukenes 42 Clinical Syndromes 271G. Haukenes and J. R. Pattison Index 277

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Book SynopsisChronicles the emergence and transformation of hemophilia community. This book sets the story within our national political landscape - where the disease is also a social, psychological, and economic experience.

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Book SynopsisOffers a template that can guide individuals and families through the decision-making process and offers additional resources where they can gain more information.Trade Review"Dr. Zallen has a unique talent for translating complicated scientific and ethical matters around genetic screening into understandable concepts that families and individuals can use to make decisions about risk and testing." -- Abbey S. Myers * founder and former president of the National Organization for Rare Disorders *"New genetic tests are being developed and offered at a dizzying pace, considerably outstripping the ability of most practicing physicians, let alone the general public, to understand how best to use them. Doris Teichler Zallen here offers a valuable guide, informed by both a thorough grasp of the underlying genetic science as well as the actual experiences of others who have faced difficult decisions to be tested or not." -- Howard Brody, MD, PhD * University of Texas Medical Branch-Galveston *"Doris Teichler Zallen provides readers with a refreshingly honest and carefully researched up-to-date discussion about the utility and limitations of predictive genetic testing. Seamlessly woven throughout the book are candid first-person accounts from diverse men and women—individuals who vividly describe both their positive and negative experiences associated with genetic testing—making this a captivating book that broadens our minds while touching our hearts." -- Elizabeth M. Petty, MD * University of Michigan Medical School *"With rapidly changing developments in genetic resesarch, new information is needed on a regular basis, and Zallen's well-written, reasonably priced volume is the perfect answer. The guidance here will go a long way toward helping individuals make the choice that is right for their own personal circumstances. Essential." -- Tina Neville * Library Journal *"The book's rich discussion of ethical issues will provide a sound knowledge base for readers ranging from patients and their families to advanced undergraduated to health care providers. This is an exceptional resource that this reader could not put down. Highly recommended." * Choice *"Dr. Zallen has a unique talent for translating complicated scientific and ethical matters around genetic screening into understandable concepts that families and individuals can use to make decisions about risk and testing." -- Abbey S. Myers * founder and former president of the National Organization for Rare Disorders *"New genetic tests are being developed and offered at a dizzying pace, considerably outstripping the ability of most practicing physicians, let alone the general public, to understand how best to use them. Doris Teichler Zallen here offers a valuable guide, informed by both a thorough grasp of the underlying genetic science as well as the actual experiences of others who have faced difficult decisions to be tested or not." -- Howard Brody, MD, PhD * University of Texas Medical Branch-Galveston *"Doris Teichler Zallen provides readers with a refreshingly honest and carefully researched up-to-date discussion about the utility and limitations of predictive genetic testing. Seamlessly woven throughout the book are candid first-person accounts from diverse men and women—individuals who vividly describe both their positive and negative experiences associated with genetic testing—making this a captivating book that broadens our minds while touching our hearts." -- Elizabeth M. Petty, MD * University of Michigan Medical School *"With rapidly changing developments in genetic resesarch, new information is needed on a regular basis, and Zallen's well-written, reasonably priced volume is the perfect answer. The guidance here will go a long way toward helping individuals make the choice that is right for their own personal circumstances. Essential." -- Tina Neville * Library Journal *"The book's rich discussion of ethical issues will provide a sound knowledge base for readers ranging from patients and their families to advanced undergraduated to health care providers. This is an exceptional resource that this reader could not put down. Highly recommended." * Choice *Table of ContentsList of Figures and Tables Preface Important Note Introduction: Genetic Tests Are Different A Brief Overview of Susceptibility-Gene Testing Am I at a Higher Risk for This Disease than Other People? Will the Test Give Me Useful Information? Is This the Right Time in My Life to Be Taking This Test? Will the Advantages Gained from Having the Genetic Information Outweigh the Disadvantages? Decisions, Decisions Deciding about Other Types of Genetic Tests The Future of Genetic Medicine Appendix. A Brief Introduction to Genetics Glossary Resources Index

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Book SynopsisThe first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations. New contributors reflecting broader international authorship and even greater expertise Greater emphasis throughout on the clinical importance and application of information about cytogenetic and molecular aberrations Includes a complete coverage of chromosome aberrations in cancer based on an assessment of the 60,000 neoplasms cytogenetically investigated to date Now produced in full color for enhanced clarity Covers how molecular genetic data (PCR-based and sequencing information) are collated with the cytogenetic data where pertinent Discusses how molecular cytogeTable of ContentsContributors vii Preface to the Fourth Edition ix 1 How it all began: cancer cytogenetics before sequencing 1Felix Mitelman and Sverre Heim 2 Cytogenetic methods 11David Gisselsson 3 Cytogenetic nomenclature 19Sverre Heim and Felix Mitelman 4 Nonrandom chromosome abnormalities in cancer: an overview 26Sverre Heim and Felix Mitelman 5 From chromosomes to genes: searching for pathogenetic fusions in cancer 42Ioannis Panagopoulos 6 Acute myeloid leukemia 62Bertil Johansson and Christine J. Harrison 7 Myelodysplastic syndromes 126Harold J. Olney and Michelle M. Le Beau 8 Chronic myeloid leukemia 153Thoas Fioretos 9 Chronic myeloproliferative neoplasms 175Peter Vandenberghe and Lucienne Michaux 10 Acute lymphoblastic leukemia 198Christine J. Harrison and Bertil Johansson 11 Mature B] and T]cell neoplasms and Hodgkin lymphoma 252Reiner Siebert and Sietse M. Aukema 12 Tumors of the upper aerodigestive tract 332Susanne M. Gollin 13 Tumors of the lung 361Penny Nymark, Eeva Kettunen and Sakari Knuutila 14 Tumors of the digestive tract 373Georgia Bardi and Sverre Heim 15 Tumors of the urinary tract 401Paola Dal Cin 16 Tumors of the breast 426Manuel R. Teixeira, Nikos Pandis and Sverre Heim 17 Tumors of the female genital organs 447Francesca Micci and Sverre Heim 18 Tumors of the male genital organs 481Manuel R. Teixeira and Sverre Heim 19 Tumors of endocrine glands 497Jörn Bullerdiek and David Gisselsson 20 Tumors of the nervous system 515Petter Brandal and Sverre Heim 21 Tumors of the eye 538Karen Sisley 22 Tumors of the skin 555Fredrik Mertens, Felix Mitelman and Sverre Heim 23 Tumors of bone 566Fredrik Mertens and Nils Mandahl 24 Soft tissue tumors 583Nils Mandahl and Fredrik Mertens Index 615

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