Haematology Books
Elsevier - Health Sciences Division Diagnostic Pathology Spleen
Book SynopsisTrade Review"This book has grown since the first edition to maintain its standing as a comprehensive text (including 14 new chapters). Overall, this book provides all the essential knowledge on splenic pathology in one single resource. It is ideal for daily use as a reference but is also an excellent training resource for learners." ©Doody's Review Service, 2022, Anna B Owczarczyk, MD, PHD (University of Michigan Medical School) Doody's Score: 5 Stars!Table of ContentsSECTION 1: HISTOLOGY, FUNCTION, AND DEVELOPMENT OF SPLEEN NORMAL HISTOLOGY 4 Introduction to Spleen Mohammad A. Vasef, MD and Jeremy C. Wallentine, MD 12 Imaging of Splenic Disorders Mohammad A. Vasef, MD 18 Handling, Processing, and Gross Pathology of Spleen Mohammad A. Vasef, MD 26 Fine-Needle Aspiration and Core Biopsy of Spleen Mohammad A. Vasef, MD 32 Immunohistochemistry of Spleen Aaron Auerbach, MD, MPH 40 Flow Cytometry Nadine Aguilera, MD 46 Molecular Techniques Nadine Aguilera, MD SECTION 2: NONNEOPLASTIC SPLENIC DISORDERS LYMPHOID HYPERPLASIA 54 Florid Follicular Hyperplasia Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH 56 Autoimmune Disease Nadine Aguilera, MD 62 HIV in Spleen Nadine Aguilera, MD 68 Castleman Disease Nadine Aguilera, MD 70 Marginal Zone Hyperplasia Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH GRANULOMATOUS LESIONS/DISORDERS 72 Lipogranulomas Jeffrey Vos, MD 78 Sarcoidosis Ellina Hall, DO and Aaron Auerbach, MD, MPH 82 Chronic Granulomatous Disease Aaron Auerbach, MD, MPH INFECTIONS 86 Mycobacteriosis Nadine Aguilera, MD 90 Selected Bacterial Infections Aaron Auerbach, MD, MPH 94 Candidiasis Aaron Auerbach, MD, MPH 96 Histoplasmosis Nadine Aguilera, MD 98 Cryptococcosis Nadine Aguilera, MD 100 Coccidioidomycosis Aaron Auerbach, MD, MPH 104 Pneumocystosis Aaron Auerbach, MD, MPH 108 Infectious Mononucleosis Nadine Aguilera, MD 112 Cytomegalovirus Infection Nadine Aguilera, MD 114 Herpes Simplex Virus Infection Aaron Auerbach, MD, MPH and Nadine Aguilera, MD 116 Echinococcosis Aaron Auerbach, MD, MPH 120 Malaria Nadine Aguilera, MD NONINFECTIOUS CYSTS 122 Epithelial Cyst Ellina Hall, DO and Aaron Auerbach, MD, MPH 124 False Cyst Ellina Hall, DO and Aaron Auerbach, MD, MPH NONNEOPLASTIC VASCULAR PROCESSES 126 Chronic Passive Congestion Ellina Hall, DO and Aaron Auerbach, MD, MPH 128 Infarct Jeffrey Vos, MD 136 Peliosis Ellina Hall, DO and Aaron Auerbach, MD, MPH 138 Sclerosing Angiomatoid Nodular Transformation Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD RED CELL DISORDERS 144 Sickle Cell Disease Aaron Auerbach, MD, MPH and Ellina Hall, DO 146 Thalassemia Nadine Aguilera, MD and Aaron Auerbach, MD, MPH 150 Hereditary Spherocytosis Nadine Aguilera, MD 152 Thrombotic Thrombocytopenic Purpura Aaron Auerbach, MD, MPH MISCELLANEOUS LESIONS/DISORDERS 158 Heterotaxy Syndromes Aaron Auerbach, MD, MPH 160 Congenital Splenic Abnormalities Nadine Aguilera, MD 164 Extramedullary Hematopoiesis Ellina Hall, DO and Aaron Auerbach, MD, MPH 166 Gamna-Gandy Bodies Nadine Aguilera, MD 168 Hemophagocytic Lymphohistiocytosis Nadine Aguilera, MD 174 Immune Thrombocytopenic Purpura Ellina Hall, DO and Aaron Auerbach, MD, MPH 178 Niemann-Pick Disease Meenakshi A. Nandedkar, MD and Nadine Aguilera, MD 184 Gaucher Disease Meenakshi A. Nandedkar, MD and Nadine Aguilera, MD 188 Sea-Blue (Ceroid) Histiocytosis Mohammad A. Vasef, MD 192 Gangliosidosis Lysosomal Disorder Mohammad A. Vasef, MD 194 Therapy Effect on Spleen Aaron Auerbach, MD, MPH 202 Traumatic and Nontraumatic Splenic Injuries Mohammad A. Vasef, MD SECTION 3: NEOPLASTIC SPLENIC DISORDERS BENIGN MESENCHYMAL LESIONS 208 Introduction to Vascular Lesions Nadine Aguilera, MD 210 Hemangioma Nadine Aguilera, MD 218 Lymphangioma Nadine Aguilera, MD 222 Littoral Cell Angioma Nadine Aguilera, MD 228 Inflammatory Pseudotumor Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 236 Postchemotherapy Histiocyte-Rich Pseudotumor of Spleen Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 242 Splenic Hamartoma Nadine Aguilera, MD 246 Myelolipoma Aaron Auerbach, MD, MPH MALIGNANT OR POTENTIALLY MALIGNANT MESENCHYMAL LESIONS 248 Angiosarcoma Nadine Aguilera, MD 256 Hemangioendothelioma Nadine Aguilera, MD 258 Kaposi Sarcoma Nadine Aguilera, MD 260 Leiomyosarcoma Aaron Auerbach, MD, MPH 266 Gastrointestinal Stromal Tumor Aaron Auerbach, MD, MPH 272 Follicular Dendritic Cell Sarcoma Aaron Auerbach, MD, MPH 280 Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 286 Langerhans Cell Histiocytosis Guanghua Wang, MD 292 Histiocytic Sarcoma Nadine Aguilera, MD LYMPHOMA 300 Introduction to Lymphoma Mohammad A. Vasef, MD 310 Splenic Marginal Zone Lymphoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 318 Hairy Cell Leukemia Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 326 Hairy Cell Leukemia Variant Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 334 Lymphoplasmacytic Lymphoma Aaron Auerbach, MD, MPH 342 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 350 Follicular Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 358 Mantle Cell Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 366 Leukemic Nonnodal Mantle Cell Lymphoma Mohammad A. Vasef, MD 370 Splenic Diffuse Red Pulp B-Cell Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 376 B-Cell Prolymphocytic Leukemia Aaron Auerbach, MD, MPH and Nadine Aguilera, MD 378 Diffuse Large B-Cell Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 384 Fibrin-Associated Large B-Cell Lymphoma in Splenic False Cyst Mohammad A. Vasef, MD 390 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Jeffrey Vos, MD 398 Burkitt Lymphoma Aaron Auerbach, MD, MPH 406 Classic Hodgkin Lymphoma Jeffrey Vos, MD 416 Nodular Lymphocyte-Predominant Hodgkin Lymphoma Aaron Auerbach, MD, MPH 426 Peripheral T-Cell Lymphoma, Unspecified Mohammad A. Vasef, MD 432 Hepatosplenic T-Cell Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 440 T-Cell Prolymphocytic Leukemia Mohammad A. Vasef, MD 448 T-Cell Large Granular Lymphocytic Leukemia Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 456 Aggressive NK-Cell Leukemia Aaron Auerbach, MD, MPH 462 Transformation of Splenic Disorders Nadine Aguilera, MD LEUKEMIA 466 Acute Myeloid Leukemia Nadine Aguilera, MD 474 Lymphoblastic Leukemia/Lymphoma Nadine Aguilera, MD CHRONIC MYELOPROLIFERATIVE NEOPLASMS/MYELODYSPLASTIC SYNDROMES 480 Myeloproliferative Neoplasm Overview Nadine Aguilera, MD 482 Chronic Myeloid Leukemia, BCR::ABL1 Positive Nadine Aguilera, MD 488 Essential Thrombocythemia Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH 492 Polycythemia Vera Guanghua Wang, MD 496 Primary Myelofibrosis Jeffrey Vos, MD 506 Mastocytosis Mohammad A. Vasef, MD 514 Chronic Myelomonocytic Leukemia Mohammad A. Vasef, MD PLASMA CELL-ASSOCIATED DISORDERS 520 Amyloidosis Nadine Aguilera, MD 526 Heavy Chain Disease Aaron Auerbach, MD, MPH 530 Plasma Cell Myeloma/Plasmacytoma Nadine Aguilera, MD and Aaron Auerbach, MD, MPH METASTASIS 534 Metastatic Tumors Ellina Hall, DO and Aaron Auerbach, MD, MPH
£184.49
Elsevier - Health Sciences Division Neonatology Questions and Controversies
Book SynopsisTable of ContentsSECTION 1 HEMATOLOGY 1 Innovations in Screening and Management of Neonatal Hyperbilirubinemia 2 The Pivotal Role of Macrophages in the Pathogenesis of Necrotizing Enterocolitis 3 Nucleated Red Blood Cells in Neonatal Medicine 4 Age-Appropriate Biology of Neonatal Neutrophils 5 New Erythrocyte Diagnostic Parameters in Neonatal Medicine 6 Neonatal Iron Homeostasis 7 Risk Factors for Iron Deficiency in Neonates 8 Using Targeted Genetic Panels to Find the Causes of Neonatal Hemolytic Anemia SECTION 2 TRANSFUSION MEDICINE 9 Erythropoietin and Darbepoetin Use in the NICU 10 NICU Transfusion Guidelines and Strategies to Minimize Transfusions 11 Neonatal Blood Banking and Transfusion: Current Questions and Controversies 12 Recent Advances in NICU Platelet Transfusions 13 Novel Approaches to Identify NICU Patients Who Would Benefit From Platelet Transfusions 14 Evidence-Based Guidelines for Administering Fresh Frozen Plasma in the NICU 15 Pathophysiologic Importance of Platelets in Neonatal Necrotizing Enterocolitis Index
£65.69
Elsevier - Health Sciences Division Procedures in Phlebotomy
Book SynopsisTable of ContentsPart 1: The Practice of Phlebotomy 1. Introduction to Phlebotomy 2. Anatomy and Physiology 3. Infectious Diseases and Their Prevention 4. Medical Terminology 5. Equipment 6. Proper Procedures for Venipuncture 7. Special Collection Procedures 8. Neonatal and Geriatric Procedures and Considerations 9. Considerations and Complications of Phlebotomy 10. The Versatile Phlebotomist and Point-of-Care Testing Part 2: Professional Issues 11. Interpersonal Communication and Professionalism 12. Phlebotomy Department Management 13. Total Quality in Phlebotomy Service 14. Medical-Legal Issues and Health Law Procedures Appendix A: Answers to Chapter Review Questions Appendix B: Practice Examination for Certification Appendix C: Helpful Spanish Terms and Phrases Glossary Index
£48.44
S Karger AG Fast Facts für Patientinnen Leben mit
Book Synopsis
£9.03
Urban & Fischer/Elsevier Praktikum der mikroskopischen Hmatologie
Book Synopsis
£34.20
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Fachübergreifende Aspekte der Hämostaseologie V: 7. Heidelberger Symposium Hämostaseologie und Anaesthesie, 7./8. September 2001
Book SynopsisDas 7. Heidelberger Symposium über Hämostaseologie in der Anästhesiologie hatte als zentrales Thema die disseminierte Gerinnungsaktivierung, wie sie bei Sepsis im Rahmen der Verbrauchskoagulopathie immer noch ein wichtiges klinisches Problem ist. Die disseminierte Gerinnungsaktivierung stellt sich immer wieder mit zwei Gesichtern dar: Zum einen ist sie ein Paradepferd der wissenschaftlichen Hämostaseologie, das Modell, an dem die Gerinnung erforscht wird, zum anderen ist sie immer wieder für Enttäuschungen und Überraschungen gut, denn kaum meint man, ein Molekül und seine Wirkung verstanden zu haben, so lehrt die klinische Erfahrung, dass dies nicht so einfach ist, wie man ursprünglich dachte.Table of Contents1 Gerinnung und Infektabwehr — Ein phylogenetisches Erfolgskonzept als Ursache disseminierter intravasaler Gerinnung?.- 2 Molekulare Basis für neue therapeutische Ansätze.- 3 Scoresysteme bei Sepsis und ihre Wertigkeit für die Stratifizierung von Patienten mit Gerinnungsstörungen und Sepsis.- 4 Was kostet die hämostaseologische Therapie?.- 5 Die Bedeutung der Gerinnung für die Prognose von Patienten mit Sepsis.- 6 Protein-C-Pathway.- 7 Klinische Ergebnisse der Protein-C- und rhAPC-Substitution.- 8 Treatment with AT III Concentrate in Pre-Eclampsia.- 9 Gerinnungsaktivierung bei Reanimation — Gibt es klinische Konsequenzen?.- 10 Disseminierte Gerinnungsaktivierung.- 11 Humane Prionenerkrankungen.
£42.29
Springer-Verlag New York Inc. AJCC Cancer Staging Handbook
Book SynopsisGeneral Information on Cancer Staging and End-Results Reporting.- Purposes and Principles of Cancer Staging.- Cancer Survival Analysis.- Head and Neck.- Lip and Oral Cavity.- Pharynx.- Larynx.- Nasal Cavity and Paranasal Sinuses.- Major Salivary Glands.- Thyroid.- Mucosal Melanoma of the Head and Neck.- Digestive System.- Esophagus and Esophagogastric Junction.- Stomach.- Small Intestine.- Colon and Rectum.- Anus.- Gastrointestinal Stromal Tumor.- Neuroendocrine Tumors.- Liver.- Intrahepatic Bile Ducts.- Gallbladder.- Perihilar Bile Ducts.- Distal Bile Duct.- Ampulla of Vater.- Exocrine and Endocrine Pancreas.- Thorax.- Lung.- Pleural Mesothelioma.- Musculoskeletal Sites.- Bone.- Soft Tissue Sarcoma.- Skin.- Cutaneous Squamous Cell Carcinoma and Other Cutaneous Carcinomas.- Merkel Cell Carcinoma.- Melanoma of the Skin.- Breast.- Breast.- Gynecologic Sites.- Vulva.- Vagina.- Cervix Uteri.- Corpus Uteri.- Ovary and Primary Peritoneal Carcinoma.- Fallopian Tube.- Gestational Trophoblastic Tumors.- Genitourinary Sites.- Penis.- Prostate.- Testis.- Kidney.- Renal Pelvis and Ureter.- Urinary Bladder.- Urethra.- Adrenal.- Ophthalmic Sites.- Carcinoma of the Eyelid.- Carcinoma of the Conjunctiva.- Malignant Melanoma of the Conjunctiva.- Malignant Melanoma of the Uvea.- Retinoblastoma.- Carcinoma of the Lacrimal Gland.- Sarcoma of the Orbit.- Ocular Adnexal Lymphoma.- Central Nervous System.- Brain and Spinal Cord.- Lymphoid Neoplasms.- Lymphoid Neoplasms.Trade ReviewFrom the reviews of the seventh edition:“Provide a new organ-specific classification that oncologists and other professionals who manage patients with cancer need in order to accurately classify tumours for staging. … a ‘Bible’ for oncologists, pathologists and surgeons, being also useful for all health officers, including general physicians and students, who want to remain updated in oncology. … this is a book that has to be present in all diagnostic imaging departments, as a major support to produce information adequate to the new oncology algorithms.” (Vincenzo Cuccurullo and Luigi Mansi, European Journal of Nuclear Medicine and Molecular Imaging, Vol. 38, 2011)Table of ContentsGeneral Information on Cancer Staging and End-Results Reporting.- Purposes and Principles of Cancer Staging.- Cancer Survival Analysis.- Head and Neck.- Lip and Oral Cavity.- Pharynx.- Larynx.- Nasal Cavity and Paranasal Sinuses.- Major Salivary Glands.- Thyroid.- Mucosal Melanoma of the Head and Neck.- Digestive System.- Esophagus and Esophagogastric Junction.- Stomach.- Small Intestine.- Colon and Rectum.- Anus.- Gastrointestinal Stromal Tumor.- Neuroendocrine Tumors.- Liver.- Intrahepatic Bile Ducts.- Gallbladder.- Perihilar Bile Ducts.- Distal Bile Duct.- Ampulla of Vater.- Exocrine and Endocrine Pancreas.- Thorax.- Lung.- Pleural Mesothelioma.- Musculoskeletal Sites.- Bone.- Soft Tissue Sarcoma.- Skin.- Cutaneous Squamous Cell Carcinoma and Other Cutaneous Carcinomas.- Merkel Cell Carcinoma.- Melanoma of the Skin.- Breast.- Breast.- Gynecologic Sites.- Vulva.- Vagina.- Cervix Uteri.- Corpus Uteri.- Ovary and Primary Peritoneal Carcinoma.- Fallopian Tube.- Gestational Trophoblastic Tumors.- Genitourinary Sites.- Penis.- Prostate.- Testis.- Kidney.- Renal Pelvis and Ureter.- Urinary Bladder.- Urethra.- Adrenal.- Ophthalmic Sites.- Carcinoma of the Eyelid.- Carcinoma of the Conjunctiva.- Malignant Melanoma of the Conjunctiva.- Malignant Melanoma of the Uvea.- Retinoblastoma.- Carcinoma of the Lacrimal Gland.- Sarcoma of the Orbit.- Ocular Adnexal Lymphoma.- Central Nervous System.- Brain and Spinal Cord.- Lymphoid Neoplasms.- Lymphoid Neoplasms.
£49.49
John Wiley and Sons Ltd TransfusionFree Medicine and Surgery
Book SynopsisThis book aims to be a guide to the practice of blood conservation. The first chapter discusses the legal and administrative aspects of bloodless medicine describing the legal principles and practical issues relatd to refusal of transfusion. The second is on balancing the risks and benefits of transfusion includes clinical vignettes of appropriate and inappropriate transfusion. The remainder of the book covers the principles and practice of bloodless medicine, including a chapter on the scientific issues of haemostasis and the investigation of bleeding idsorders. The book concludes with chapters on blood conservation in neonatal and paediatric surgery, the costs associated with blood transfusion and the quest for artifical blood. New chapters will be included to address blood utilization in oncology and geriatric patients.Table of ContentsContributors, ix Preface, xiii 1 History of blood transfusion and patient blood management, 1 Shannon L. Farmer, James Isbister, and Michael F. Leahy 2 The ethical complexities of transfusion-free medicine, surgery and research, 19 Katrina A. Bramstedt 3 Transfusion therapy – Balancing the risks and benefits, 28 Irina Maramica and Ira A. Shulman 4 The physiology of anemia and the threshold for blood transfusion, 61 Senthil G. Krishna, Ahsan Syed, Jason Bryant, and Joseph D. Tobias 5 Blood transfusion in surgery, 83 Sharad Sharma, Lance W Griffin, and Nicolas Jabbour 6 Current view of coagulation system, 102 Yoogoo Kang and Elia Elia 7 Topical hemostatic agents, 143 Fabrizio Di Benedetto and Giuseppe Tarantino 8 Intraoperative strategies for transfusion-free medicine, 158 Joseph D. Tobias 9 Post-operative management in transfusion-free medicine and surgery in the ICU, 207 Jean-Louis Vincent 10 The changing transfusion practice of neonatal and pediatric surgery, 222 Pamela J. Kling and Nicolas Jabbour 11 Current management of anemia in oncology, 247 Shelly Sharma and Sharad Sharma 12 Artificial blood, 271 Aryeh Shander, Mazyar Javidroozi, and Seth Perelman 13 Translational strategies to minimize transfusion requirement in liver surgery and transplantation: Targeting ischemia-reperfusion injury, 289 Reza F. Saidi and S. Kamran Hejazi Kenari 14 Legal and administrative issues related to transfusion-free medicine and surgery programs, 315 Randy Henderson and Nicolas Jabbour 15 Basic principles of bloodless medicine and surgery, 338 Nicolas Jabbour Index, 347
£65.66
John Wiley and Sons Ltd de Gruchys Clinical Haematology in Medical
Book SynopsisThis book has been highly successful ever since it was first published in 1958. Emphasis throughout is placed on diagnosis and management, with particular stress on clinical problems as they confront the practitioner. The new fifth edition has been completely revised and updated to take account of important recent developments such as AIDS, lymphomas and leukaemias, and in order to contain the length, some sections of the book have been condensed.Trade Review"Although this book is clearly orientated to bedside problems, it never fails to explain the usefulness and limitations of laboratory investigations. Such a book is probably needed even more now than it was in 1958 and ... this edition will continue to fill the need admirably ... it remains the best haematology reference for the general physician" British Medical JournalTable of ContentsPreface to Fifth Edition. Preface to First Edition. 1. Formation Blood Cells; Bone Marrow Biopsy. 2. The Red Cell; Basic Aspects of Anaemia. 3. Hypochromic Anaemia: Iron Deficiency and Siberoblastic Anaemia. 4. The Megaloblastic Anaemias. 5. Anaemia in Systemic Disorder; Diagnosis in Normochromic Normocytic Anaemia. 6. Pancytopenia; Aplastic Anaemias. 7. Disorders of Haemoglobin Structure and Synthesis. 8. The Haemolytic Anaemias. 9. White Cells: Neutrophilia and Eosinophilia; Neutropenia and Agranulocytosis; Infectious Monoucleosis. 10. The Leukaemias. 11. Tumours of Lymphiod Tissues; The Paraproteinaemias. 12. Polycythaemia; Myelofibrosis. 13. The Spleen: Hypersplenism and Splenomgaly. 14. The Haemorrhagic Disorder; Capillary and Platelet Defects. 15. Coagulation Disorder. 16. Thrombosis: Clinical Features and Management. 17. Blood Groups; Blood Transfusion; Acquired Immune Deficiency Syndrome. Index.
£125.06
Wiley Simple Guide to Blood Gas Analysis
Book SynopsisAccurate analysis of blood gases is vital to give information on a patient's respiratory and circulation state as well as the adequacy of resuscitation. This text guides the reader through the basic principles and a new system of interpretation.Table of ContentsHow to take an arterial blood gas sample; the survival guide to understanding acid-base balance; too much alkali; the survival guide to understanding oxygenation; too little oxygenation; complex situations; special situations; putting it all together; self assessments.
£55.05
John Wiley and Sons Ltd Blood Science
Book Synopsis* Integrated textbook combining three subjects, haematology, clinical biochemistry and immunology to provide a one-stop text on blood science, in line with the new IBMS and NHS training structure * Suitable for blood science courses opening in many universities at senior Undergraduate level (units) and Masters level.Table of ContentsPreface, xiii Acknowledgements, xv List of Abbreviations, xvii About the Companion Website, xxi 1 Introduction to Blood Science, 1 1.1 What is blood science?, 1 1.2 Biochemistry, 6 1.3 Blood transfusion, 8 1.4 Genetics, 10 1.5 Haematology, 14 1.6 Immunology, 17 1.7 The role of blood science in modern healthcare, 19 1.8 What this book will achieve, 22 Summary, 23 References, 23 Further reading, 23 Web sites, 23 2 Analytical Techniques in Blood Science, 25 2.1 Venepuncture, 25 2.2 Anticoagulants, 26 2.3 Sample identification and tracking, 27 2.4 Technical and analytical confidence, 27 2.5 Major techniques, 32 2.6 Molecular genetics, 43 2.7 Point of care testing, 47 2.8 Health and safety in the laboratory, 48 Summary, 49 Further reading, 50 Web sites, 50 3 The Physiology of the Red Blood Cell, 51 3.1 Introduction, 51 3.2 The development of blood cells, 52 3.3 Erythropoiesis, 56 3.4 The red cell membrane, 58 3.5 The cytoplasm of the red cell, 60 3.6 Oxygen transport, 66 3.7 Recycling the red cell, 68 3.8 Red cell indices in the full blood count, 69 3.9 Morphology of the red cell, 72 Summary, 74 Further reading, 74 4 The Pathology of the Red Blood Cell, 75 4.1 Introduction: diseases of red cells, 75 4.2 Anaemia resulting from attack on, or stress to, the bone marrow, 78 4.3 Anaemia due to deficiency, 80 4.4 Intrinsic defects in the red cell, 85 4.5 External factors acting on healthy cells, 100 4.6 Erythrocytosis and polycythaemia, 103 4.7 Molecular genetics and red cell disease, 105 4.8 Inclusion bodies, 105 4.9 Case studies, 105 Summary, 107 References, 107 Further reading, 107 5 White Blood Cells in Health and Disease, 109 5.1 Introduction, 109 5.2 Leukopoiesis, 111 5.3 Neutrophils, 115 5.4 Lymphocytes, 116 5.5 Monocytes, 117 5.6 Eosinophils, 118 5.7 Basophils, 119 5.8 Leukocytes in action, 120 5.9 White cells in clinical medicine, 127 5.10 Case studies, 132 Summary, 132 Further reading, 133 6 White Blood Cell Malignancy 135 6.1 The genetic basis of leukocyte malignancy, 135 6.2 Tissue techniques in haemato-oncology, 139 6.3 Leukaemia, 141 6.4 Lymphoma, 149 6.5 Myeloma and related conditions, 152 6.6 Myelofibrosis and myelodysplasia, 157 6.7 Case studies, 157 Summary, 158 Further reading, 159 Guidelines, 159 7 The Physiology and Pathology of Haemostasis, 161 7.1 The blood vessel wall, 162 7.2 Platelets, 163 7.3 The coagulation pathway, 165 7.4 Haemostasis as the balance between thrombus formation and removal, 168 7.5 The haemostasis laboratory, 171 7.6 The pathology of thrombosis, 173 Summary, 175 Further reading, 175 8 The Diagnosis and Management of Disorders of Haemostasis, 177 8.1 Thrombosis 1: overactive platelets and thrombocytosis, 177 8.2 Thrombosis 2: overactive coagulation, 181 8.3 Haemorrhage 1: platelet underactivity and thrombocytopenia, 193 8.4 Haemorrhage 2: coagulation underactivity, 199 8.5 Disseminated intravascular coagulation, 203 8.6 Molecular genetics in haemostasis, 204 8.7 Case studies, 205 Summary, 206 References, 206 Further reading, 207 Guidelines, 207 Web sites, 207 9 Immunopathology, 209 9.1 Introduction, 209 9.2 Basics of the immune system, 210 9.3 Humoral immunity, 212 9.4 Immunopathology 1: immunodeficiency, 215 9.5 Immunopathology 2: hypersensitivity, 221 9.6 Immunopathology 3: autoimmune disease, 226 9.7 Immunotherapy, 232 9.8 The immunology laboratory, 234 9.9 Case studies, 238 Summary, 239 References, 240 Further reading, 240 Guidelines, 240 Web sites, 240 10 Immunogenetics and Histocompatibility, 241 10.1 The genetics of antigen recognition, 241 10.2 Human leukocyte antigens, 245 10.3 Transplantation, 251 10.4 Autoimmunity and human leukocyte antigens, 257 Summary, 260 Further reading, 260 Guidelines, 260 Web sites, 260 11 Blood Transfusion, 261 11.1 Blood collection and processing, 262 11.2 Blood groups, 265 11.3 Laboratory practice of blood transfusion, 273 11.4 Clinical practice of blood transfusion, 279 11.5 Hazards of blood transfusion, 281 Summary, 284 References, 284 Further reading, 284 Guidelines, 284 Web sites, 285 12 Waste Products, Electrolytes and Renal Disease, 287 12.1 Renal anatomy and physiology, 287 12.2 Homeostasis, 288 12.3 Excretion, 295 12.4 Renal endocrinology, 297 12.5 Renal disease, 298 12.6 Case studies, 301 Summary, 303 Further reading, 303 Guidelines, 303 Web sites, 303 13 Hydrogen Ions, pH, and Acid–Base Disorders, 305 13.1 Ions and molecules, 305 13.2 Blood gases, 308 13.3 Acidosis (pH <7.3), 312 13.4 Alkalosis (pH >7.5), 313 13.5 Mixed acid–base conditions, 314 13.6 Clinical interpretation, 314 13.7 Case studies, 315 Summary, 316 Further reading, 317 Web site, 317 14 Glucose, Lipids and Atherosclerosis, 319 14.1 Glucose, 319 14.2 Dyslipidaemia, 333 14.3 Atherosclerosis, 343 14.4 Case studies, 347 Summary, 348 Further reading, 348 Guidelines, 349 Web sites, 349 15 Calcium, Phosphate, Magnesium and Bone Disease, 351 15.1 Calcium, 352 15.2 Phosphates, 355 15.3 Magnesium, 355 15.4 The laboratory, 355 15.5 Disorders of calcium homeostasis, 357 15.6 Disorders of phosphate homeostasis, 360 15.7 Disorders of magnesium homeostasis, 362 15.8 Bone physiology, 363 15.9 Bone disease, 364 15.10 Case studies, 368 Summary, 369 Further reading, 370 Guidelines, 370 Web sites, 370 16 Nutrients and Gastrointestinal Disorders, 371 16.1 Nutrients, 371 16.2 The intestines, 375 16.3 Case studies, 381 Summary, 382 Further reading, 382 Guidelines, 382 17 Liver Function Tests and Plasma Proteins, 383 17.1 Anatomy and physiology of the liver, 384 17.2 Liver function tests, 389 17.3 Diseases of the liver, 390 17.4 Plasma proteins, 396 17.5 Case studies, 405 Summary, 406 Further reading, 406 Web sites, 406 18 Hormones and Endocrine Disorders, 407 18.1 Endocrine physiology, 407 18.2 The pathology of the endocrine system, 417 18.3 Case studies, 434 Summary, 435 Further reading, 435 Web sites, 436 19 Cancer and Tumour Markers, 437 19.1 General concepts in cancer biology, 437 19.2 Blood science and cancer, 440 19.3 Molecular genetics, 444 19.4 Case studies, 445 Summary, 446 Further reading, 446 Guidelines, 447 Web sites, 447 20 Inherited Metabolic Disorders, 449 20.1 The genetics of inheritance, 449 20.2 Molecular inherited metabolic disorders, 451 20.3 Organelle inherited metabolic disorders, 455 20.4 Antenatal diagnosis and neonatal screening, 455 20.5 Case studies, 456 Summary, 457 Further reading, 457 21 Drugs and Poisons, 459 21.1 Toxicology, 459 21.2 Toxicology of specific compounds, 461 21.3 Therapeutic drug monitoring, 465 21.4 Case studies, 468 Summary, 469 References, 469 Further reading, 469 22 Case Reports in Blood Science, 471 Abbreviations, 471 Case report 1, 472 Anaemia, hypercalcaemia, proteinuria, myeloma Case report 2, 473 Diabetes, glycated haemoglobin, chronic renal failure Case report 3, 474 Acute kidney injury, leucocytosis, neutrophilia, viruses Case report 4, 475 Part 1: Obesity, colorectal cancer, CEA, hypothyroidism. Part 2: Alcoholism, raised GGT and triacylglycerols Case report 5, 477 Part 1: No abnormalities. Part 2: Asthma, raised IgE. Part 3: Falling haemoglobin, rising ESR, lung cancer Case report 6, 479 Hypothyroidism, marginally reduced haemoglobin Case report 7, 480 Raised CRP, ESR, rheumatoid factor and anti-nuclear antibodies; borderline anti-dsDNA antibodies, low C3, low eGFR and so mild renal failure, systemic lupus erythematosus Case report 8, 481 Normal blood results in renal transplantation Case report 9, 482 Falling albumin, eGFR, haemoglobin, red cell count and platelets, rising ESR, white cell count and neutrophila, CRP, urea and creatinine, septicaemia Case report 10, 484 Microcytic anaemia, thrombocytopenia, lymphocytosis, abnormal LFTs, falling albumin, raised CRP, myositis with raised CK, viruses Case report 11, 486 Acidosis, hyperglycaemia, diabetic ketoacidosis, acute renal injury, raised urea and creatinine Case report 12, 487 Low haemoglobin, thrombocytopenia, raised CRP and d-dimers, abnormal LFTs, malaria, pregnancy Case report 13, 488 Raised aldosterone, hypernatraemia, hypokalaemia, Conn’s syndrome Case report 14, 489 Paediatric diabetic ketoacidosis, hyperglycaemia, low bicarbonate, raised phosphates, ALP and proteins References, 490 Appendix: Reference Ranges, 491 Further Reading, 493 Glossary, 495 Index, 519
£111.10
John Wiley and Sons Ltd Blood Science Principles and Pathology
Book Synopsis* Integrated textbook combining three subjects, haematology, clinical biochemistry and immunology to provide a one-stop text on blood science, in line with the new IBMS and NHS training structure * Suitable for blood science courses opening in many universities at senior Undergraduate level (units) and Masters level.Table of ContentsPreface, xiii Acknowledgements, xv List of Abbreviations, xvii About the Companion Website, xxi 1 Introduction to Blood Science, 1 1.1 What is blood science?, 1 1.2 Biochemistry, 6 1.3 Blood transfusion, 8 1.4 Genetics, 10 1.5 Haematology, 14 1.6 Immunology, 17 1.7 The role of blood science in modern healthcare, 19 1.8 What this book will achieve, 22 Summary, 23 References, 23 Further reading, 23 Web sites, 23 2 Analytical Techniques in Blood Science, 25 2.1 Venepuncture, 25 2.2 Anticoagulants, 26 2.3 Sample identification and tracking, 27 2.4 Technical and analytical confidence, 27 2.5 Major techniques, 32 2.6 Molecular genetics, 43 2.7 Point of care testing, 47 2.8 Health and safety in the laboratory, 48 Summary, 49 Further reading, 50 Web sites, 50 3 The Physiology of the Red Blood Cell, 51 3.1 Introduction, 51 3.2 The development of blood cells, 52 3.3 Erythropoiesis, 56 3.4 The red cell membrane, 58 3.5 The cytoplasm of the red cell, 60 3.6 Oxygen transport, 66 3.7 Recycling the red cell, 68 3.8 Red cell indices in the full blood count, 69 3.9 Morphology of the red cell, 72 Summary, 74 Further reading, 74 4 The Pathology of the Red Blood Cell, 75 4.1 Introduction: diseases of red cells, 75 4.2 Anaemia resulting from attack on, or stress to, the bone marrow, 78 4.3 Anaemia due to deficiency, 80 4.4 Intrinsic defects in the red cell, 85 4.5 External factors acting on healthy cells, 100 4.6 Erythrocytosis and polycythaemia, 103 4.7 Molecular genetics and red cell disease, 105 4.8 Inclusion bodies, 105 4.9 Case studies, 105 Summary, 107 References, 107 Further reading, 107 5 White Blood Cells in Health and Disease, 109 5.1 Introduction, 109 5.2 Leukopoiesis, 111 5.3 Neutrophils, 115 5.4 Lymphocytes, 116 5.5 Monocytes, 117 5.6 Eosinophils, 118 5.7 Basophils, 119 5.8 Leukocytes in action, 120 5.9 White cells in clinical medicine, 127 5.10 Case studies, 132 Summary, 132 Further reading, 133 6 White Blood Cell Malignancy 135 6.1 The genetic basis of leukocyte malignancy, 135 6.2 Tissue techniques in haemato-oncology, 139 6.3 Leukaemia, 141 6.4 Lymphoma, 149 6.5 Myeloma and related conditions, 152 6.6 Myelofibrosis and myelodysplasia, 157 6.7 Case studies, 157 Summary, 158 Further reading, 159 Guidelines, 159 7 The Physiology and Pathology of Haemostasis, 161 7.1 The blood vessel wall, 162 7.2 Platelets, 163 7.3 The coagulation pathway, 165 7.4 Haemostasis as the balance between thrombus formation and removal, 168 7.5 The haemostasis laboratory, 171 7.6 The pathology of thrombosis, 173 Summary, 175 Further reading, 175 8 The Diagnosis and Management of Disorders of Haemostasis, 177 8.1 Thrombosis 1: overactive platelets and thrombocytosis, 177 8.2 Thrombosis 2: overactive coagulation, 181 8.3 Haemorrhage 1: platelet underactivity and thrombocytopenia, 193 8.4 Haemorrhage 2: coagulation underactivity, 199 8.5 Disseminated intravascular coagulation, 203 8.6 Molecular genetics in haemostasis, 204 8.7 Case studies, 205 Summary, 206 References, 206 Further reading, 207 Guidelines, 207 Web sites, 207 9 Immunopathology, 209 9.1 Introduction, 209 9.2 Basics of the immune system, 210 9.3 Humoral immunity, 212 9.4 Immunopathology 1: immunodeficiency, 215 9.5 Immunopathology 2: hypersensitivity, 221 9.6 Immunopathology 3: autoimmune disease, 226 9.7 Immunotherapy, 232 9.8 The immunology laboratory, 234 9.9 Case studies, 238 Summary, 239 References, 240 Further reading, 240 Guidelines, 240 Web sites, 240 10 Immunogenetics and Histocompatibility, 241 10.1 The genetics of antigen recognition, 241 10.2 Human leukocyte antigens, 245 10.3 Transplantation, 251 10.4 Autoimmunity and human leukocyte antigens, 257 Summary, 260 Further reading, 260 Guidelines, 260 Web sites, 260 11 Blood Transfusion, 261 11.1 Blood collection and processing, 262 11.2 Blood groups, 265 11.3 Laboratory practice of blood transfusion, 273 11.4 Clinical practice of blood transfusion, 279 11.5 Hazards of blood transfusion, 281 Summary, 284 References, 284 Further reading, 284 Guidelines, 284 Web sites, 285 12 Waste Products, Electrolytes and Renal Disease, 287 12.1 Renal anatomy and physiology, 287 12.2 Homeostasis, 288 12.3 Excretion, 295 12.4 Renal endocrinology, 297 12.5 Renal disease, 298 12.6 Case studies, 301 Summary, 303 Further reading, 303 Guidelines, 303 Web sites, 303 13 Hydrogen Ions, pH, and Acid–Base Disorders, 305 13.1 Ions and molecules, 305 13.2 Blood gases, 308 13.3 Acidosis (pH <7.3), 312 13.4 Alkalosis (pH >7.5), 313 13.5 Mixed acid–base conditions, 314 13.6 Clinical interpretation, 314 13.7 Case studies, 315 Summary, 316 Further reading, 317 Web site, 317 14 Glucose, Lipids and Atherosclerosis, 319 14.1 Glucose, 319 14.2 Dyslipidaemia, 333 14.3 Atherosclerosis, 343 14.4 Case studies, 347 Summary, 348 Further reading, 348 Guidelines, 349 Web sites, 349 15 Calcium, Phosphate, Magnesium and Bone Disease, 351 15.1 Calcium, 352 15.2 Phosphates, 355 15.3 Magnesium, 355 15.4 The laboratory, 355 15.5 Disorders of calcium homeostasis, 357 15.6 Disorders of phosphate homeostasis, 360 15.7 Disorders of magnesium homeostasis, 362 15.8 Bone physiology, 363 15.9 Bone disease, 364 15.10 Case studies, 368 Summary, 369 Further reading, 370 Guidelines, 370 Web sites, 370 16 Nutrients and Gastrointestinal Disorders, 371 16.1 Nutrients, 371 16.2 The intestines, 375 16.3 Case studies, 381 Summary, 382 Further reading, 382 Guidelines, 382 17 Liver Function Tests and Plasma Proteins, 383 17.1 Anatomy and physiology of the liver, 384 17.2 Liver function tests, 389 17.3 Diseases of the liver, 390 17.4 Plasma proteins, 396 17.5 Case studies, 405 Summary, 406 Further reading, 406 Web sites, 406 18 Hormones and Endocrine Disorders, 407 18.1 Endocrine physiology, 407 18.2 The pathology of the endocrine system, 417 18.3 Case studies, 434 Summary, 435 Further reading, 435 Web sites, 436 19 Cancer and Tumour Markers, 437 19.1 General concepts in cancer biology, 437 19.2 Blood science and cancer, 440 19.3 Molecular genetics, 444 19.4 Case studies, 445 Summary, 446 Further reading, 446 Guidelines, 447 Web sites, 447 20 Inherited Metabolic Disorders, 449 20.1 The genetics of inheritance, 449 20.2 Molecular inherited metabolic disorders, 451 20.3 Organelle inherited metabolic disorders, 455 20.4 Antenatal diagnosis and neonatal screening, 455 20.5 Case studies, 456 Summary, 457 Further reading, 457 21 Drugs and Poisons, 459 21.1 Toxicology, 459 21.2 Toxicology of specific compounds, 461 21.3 Therapeutic drug monitoring, 465 21.4 Case studies, 468 Summary, 469 References, 469 Further reading, 469 22 Case Reports in Blood Science, 471 Abbreviations, 471 Case report 1, 472 Anaemia, hypercalcaemia, proteinuria, myeloma Case report 2, 473 Diabetes, glycated haemoglobin, chronic renal failure Case report 3, 474 Acute kidney injury, leucocytosis, neutrophilia, viruses Case report 4, 475 Part 1: Obesity, colorectal cancer, CEA, hypothyroidism. Part 2: Alcoholism, raised GGT and triacylglycerols Case report 5, 477 Part 1: No abnormalities. Part 2: Asthma, raised IgE. Part 3: Falling haemoglobin, rising ESR, lung cancer Case report 6, 479 Hypothyroidism, marginally reduced haemoglobin Case report 7, 480 Raised CRP, ESR, rheumatoid factor and anti-nuclear antibodies; borderline anti-dsDNA antibodies, low C3, low eGFR and so mild renal failure, systemic lupus erythematosus Case report 8, 481 Normal blood results in renal transplantation Case report 9, 482 Falling albumin, eGFR, haemoglobin, red cell count and platelets, rising ESR, white cell count and neutrophila, CRP, urea and creatinine, septicaemia Case report 10, 484 Microcytic anaemia, thrombocytopenia, lymphocytosis, abnormal LFTs, falling albumin, raised CRP, myositis with raised CK, viruses Case report 11, 486 Acidosis, hyperglycaemia, diabetic ketoacidosis, acute renal injury, raised urea and creatinine Case report 12, 487 Low haemoglobin, thrombocytopenia, raised CRP and d-dimers, abnormal LFTs, malaria, pregnancy Case report 13, 488 Raised aldosterone, hypernatraemia, hypokalaemia, Conn’s syndrome Case report 14, 489 Paediatric diabetic ketoacidosis, hyperglycaemia, low bicarbonate, raised phosphates, ALP and proteins References, 490 Appendix: Reference Ranges, 491 Further Reading, 493 Glossary, 495 Index, 519
£52.20
John Wiley and Sons Ltd Clinical Manual of Blood and Bone Marrow
Book SynopsisProviding the practicing and trainee hematologist with a practical and immediately applicable compendium of answers the Clinical Manual of Blood and Bone Marrow Transplantation covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program. Supplies the practicing and trainee hematologist with a practical and immediately applicable compendium of answers to clinical questionsCovers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant programContains concise chapters written with a focus on tables, algorithms and figures to aid rapid referralBenefits from expert contributions from an international authorshipTrade Review"... the book provides a concise practical expert review in a well-organized format of 42 chapters, each annotated with numerous practical headings to enhance focused learning. The expert authors of each chapter in the Clinical Manual of Blood and Bone Marrow Transplantation are part of that success story, and their up-to-date contributions to the field are elucidated in the clearest of terms in this worthy addition to the literature. This book is recommended for The ASCO Post readers, especially residents and fellows who are interested in pursuing a career in blood cancers" (The ASCO Post, September 2017)Table of ContentsContributors, ix Preface, xiv 1 Donor and graft selection strategy, 1Ayman Saad, Marisa B. Marques, and Shin Mineishi 2 HLA typing and implications, 9Bronwen E. Shaw and Stephen R. Spellman 3 Risk]benefit assessment in allogeneic hematopoietic transplant: Factors, scores, and models, 19Mahmoud Elsawy and Mohamed L. Sorror 4 Donor and recipient pre]transplant evaluation, 36Shuang Fu and Navneet S. Majhail 5 Autologous and allogeneic progenitor cell mobilization, 45Racquel D. Innis]Shelton and Luciano J. Costa 6 Hematopoietic stem and progenitor cell collection by apheresis: Techniques and tricks, 53Anand Padmanabhan 7 Hematopoietic cell processing: From procurement to infusion, 59Jay S. Raval, Kathryn McKay, and Yara A. Park 8 Graft manipulation: T-cell depletion and beyond, 66Christina Cho and Miguel]Angel Perales 9 Graft]versus]host disease prophylaxis, 73Melhem Solh and Asad Bashey 10 Acute lymphoblastic leukemia, 80Ghada Zakout and Adele K. Fielding 11 Acute myeloid leukemia, 89Hillard M. Lazarus and Masumi Ueda 12 Myelodysplastic syndromes, 97Melinda Biernacki and H. Joachim Deeg 13 Chronic myelogenous leukemia, 108Daniel Egan and Jerald Radich 14 Philadelphia chromosome negative myeloproliferative neoplasms, 116Nicolaus Kröger 15 Chronic lymphocytic leukemia, 123Fabienne McClanahan Lucas and John Gribben 16 Hodgkin Lymphoma, 131Anna Sureda and Eva Domingo]Domenech 17 Indolent lymphomas, 140Narendranath Epperla, Hamza Hashmi, and Mehdi Hamadani 18 Diffuse large B-cell lymphoma, 151Syed Abbas Ali, Istvan Redei, and Syed A. Abutalib 19 Mantle cell lymphoma, 164Narendranath Epperla and Timothy S. Fenske 20 T-cell lymphoma, 179Adrienne A. Phillips and Koen van Besien 21 Primary CNS lymphoma, 188Henry C. Fung, Philip Pancari, and Patricia Kropf 22 Autologous hematopoietic transplant in multiple myeloma, 194Nisha S. Joseph, Ajay K. Nooka, and Sagar Lonial 23 Allogeneic hematopoietic transplant in multiple myeloma, 207Parameswaran Hari and Binod Dhakal 24 Light]chain amyloidosis, 214Amara S. Hussain and Anita D’Souza 25 Autoimmune disorders, 221Adam Bryant and Harold Atkins 26 Testicular cancer, 229Moshe C. Ornstein, Navneet S. Majhail, and Timothy Gilligan 27 Sickle cell disease, 236Sonali Chaudhury and Shalini Shenoy 28 Hematopoietic cell transplant in thalassemia, 246Emanuele Angelucci and Federica Pilo 29 Fanconi anemia, 255Flore Sicre de Fontbrune, Jean Soulier, and Regis Peffault de Latour 30 Immunodeficiency disorders, 264Jennifer A. Kanakry and Dennis D. Hickstein 31 Inherited metabolic disorders, 272Jaap Jan Boelens and Robert F. Wynn 32 Aplastic anemia and paroxysmal nocturnal hemoglobinuria, 281Andrew C. Dietz and Michael A. Pulsipher 33 HIV infection and transplantation, 290Nitya Nathwani, Stephen J. Forman, and Amrita Krishnan 34 Engraftment and graft failure: Assessment and practical considerations, 297Yogesh Jethava, Madan Jagasia, Mohamed Mohty, and Bipin N. Savani 35 Immune reconstitution and tolerance, 304udovic Belle and William R. Drobyski 36 Donor lymphocyte infusion, 315David C. Halverson and Daniel Fowler 37 Diagnosis and treatment of acute graft]versus]host disease, 324Natasha Kekre and Vincent T. Ho 38 Diagnosis and treatment of chronic graft]versus]host disease, 334Sabarinath Venniyil Radhakrishnan and Daniel R. Couriel 39 Prevention and treatment of infection, 348Corrado Girmenia, Gian Maria Rossolini, and Claudio Viscoli 40 Early non]infectious complications after hematopoietic cell transplantation, 359Piyanuch Kongtim and Stefan O. Ciurea 41 Post]transplant lymphoproliferative disorders, 369Michael D. Keller, Conrad R. Cruz, and Catherine M. Bollard 42 Survivorship issues after transplantation, 376Vanessa E. Kennedy, Madan Jagasia, and Bipin N. Savani Index, 384
£77.36
John Wiley and Sons Ltd Clinical Endocrinology and Diabetes at a Glance
Book SynopsisTable of ContentsPreface vii Part 1 Introduction 1 1 Introduction to endocrinology 2 Part 2 Disorders of the hypothalamic–pituitary axis 5 2 The hypothalamic–pituitary axis and its assessment 6 3 Acromegaly 8 4 Cushing’s syndrome 10 5 Hypopituitarism and non-functioning pituitary adenomas 12 6 Prolactinoma and hyperprolactinaemia 14 Part 3 Disorders of thirst and fluid balance 17 7 Hypernatraemia and diabetes insipidus 18 8 Hyponatraemia and SIADH 20 Part 4 Thyroid disorders 23 9 Thyroid function 24 10 Hyperthyroidism: clinical presentation and investigation 26 11 Hyperthyroidism: management and ophthalmopathy 28 12 Hyperthyroidism: special circumstances 30 13 Hypothyroidism 32 14 Goitre, thyroid nodules and cancer 34 Part 5 Disorders of calcium homeostasis 37 15 Physiology of calcium, PTH and vitamin D metabolism 38 16 Hypercalcaemia 40 17 Hypocalcaemia 42 18 Osteoporosis 44 Part 6 Disorders of the adrenal gland 47 19 Steroid physiology and biochemical assessment 48 20 Adrenal insufficiency 50 21 Adrenocortical tumours 52 22 Disorders of the adrenal medulla 54 Part 7 Disorders of the reproductive system 57 23 Physiology of the reproductive system 58 24 Growth, puberty and sexual differentiation 60 25 Menstrual disturbance 62 26 Hyperandrogenism 64 27 Menopause and HRT 66 28 Male hypogonadism 68 29 Gynaecomastia 70 30 Infertility 72 Part 8 Neuroendocrine tumours 75 31 Neuroendocrine tumours 76 32 Neuroendocrine tumours: management 78 33 Inherited endocrine tumour syndromes 80 34 Spontaneous hypoglycaemia 82 Part 9 Endocrine emergencies 85 35 Adrenal crisis 86 36 Pituitary apoplexy 88 37 Myxoedema coma 90 38 Thyroid storm 92 39 Acute hyponatraemia 94 40 Severe hypercalcaemia 96 41 Acute hypocalcaemia 98 Part 10 Diabetes mellitus 101 42 Overview 102 43 Diagnosis and monitoring 104 44 Classification 106 45 Type 1 diabetes: aetiology and clinical presentation 108 46 Type 1 diabetes: insulin and other therapies 110 47 Type 2 diabetes: aetiology and clinical presentation 112 48 Type 2 diabetes: treatment 114 49 Macrovascular complications 116 50 Microvascular complications 118 51 Diabetic foot disease 120 52 Diabetic ketoacidosis 122 53 Hyperglycaemic hyperosmolar state 124 54 Hypoglycaemia 126 55 Peri-operative management 128 56 Management of acute illness 131 57 Insulin infusions 134 58 Pregnancy and diabetes 136 59 Genetics of diabetes 138 60 The multidisciplinary team 140 61 Lipid disorders 142 62 Appetite and weight 144 63 Obesity and anorexia 146 Index 148
£31.30
John Wiley & Sons Inc Molecular Hematology
Book SynopsisProvides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated Molecular Hematology brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more. Now in its fifth edition, Molecular Hematology is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topic
£167.15
John Wiley and Sons Ltd Alternatives to Blood Transfusion in Transfusion
Book SynopsisMeeting the needs of patients while minimizing blood transfusions requires special expertise, precise monitoring and innovative techniques. This cutting-edge resource covers all the important clinical aspects of transfusion medicine in diverse clinical settings, with a special emphasis on alternatives to transfusion. Edited by a multidisciplinary team consisting of a transfusion specialist, an anesthesiologist and an intensive care specialist this book is endorsed by the Network for Advancement of Transfusion Alternatives. The contributors review the appropriate use of fluids and of blood products, and describe the latest treatment options available to decrease the need for allogeneic blood products including: Argon beam Cell saver Harmonic scalpel Normovolemic haemodilution Synthetic erythropoietin Antifibrinolytics Recombinant factor VIIa Advanced monitoring of hemostasis Intravenous iron Trade Review"It would be of great interest to students or practitioners in laboratory and/or transfusion medicine, anesthesiology, and surgery interested in alternatives to blood transfusion. The editors and authors are credible authorities in their fields." (Doody's, 9 September 2011) "The book provides the state of the art in blood transfusion management and I shall certainly be referring to it often as I continue to develop a blood conservation programme in my own hospital." (The Bulletin of the Royal College of Pathologists, 1 July 2011) Table of ContentsContributors List ix Part 1 History and Development of Transfusion Medicine 1 1 From Blood Transfusion to Transfusion Medicine 3Alice Maniatis Part 2 Allogeneic Blood Usage—Risks and Benefits 9 2 Allogeneic Blood Components 11Rebecca Cardigan & Sheila MacLennan 3 Current Information on the Infectious Risks of Allogeneic Blood Transfusion 21Alan D. Kitchen & John A. J. Barbara 4 Immunological Complications of Blood Transfusion 31Clare Taylor Cristina Navarrete & Marcela Contreras 5 Immunomodulation and Allogeneic Blood Transfusion 47Marloes Waanders Leo Van De Watering & Anneke Brand 6 Pathogen Inactivation of Blood Components 60Chris Prowse 7 The Benefits of Allogeneic Erythrocyte Transfusion: What Evidence Do We Have? 68Neil Soni & Benjamin Thomas Part 3 Volume Replacement 83 Section 1 Plasma and Albumin 85 8 Plasma and Albumin 87Philippe L. Baele Section 2 Crystalloids and Synthetic Colloids 109 9 Pharmacology of Intravenous Fluids 111Michael F.M. James 10 Crystalloids versus Colloids: The Controversy 119Hengo Haljamäe 11 Effects of Synthetic Colloids on Hemostasis 137Sibylle A. Kozek-Langenecker & Gisela Scharbert 12 Hydroxyethyl Starch and Renal Dysfunction 150Laurent Jacob Nicholas Heming & Bertrand Guidet 13 Choice of a Synthetic Colloid for Surgery 158Joachim Boldt 14 Choice of Colloid for Intensive Care Patients 168Yasser Sakr & Yalcin Inel 15 Hypertonic Saline Solutions for the Initial Treatment of Patients with Traumatic Injuries 179Charles E. Wade & Michael A. Dubick 16 Hyperchloremic Acidosis 194Edward Burdett & Andre Vercueil Part 4 Tolerance of Anemia 203 17 Basic Principles of Oxygen Transport and Calculations 205Jean-Louis Vincent Pongdhep Theerawit & Davide Simion 18 Assessment of Tissue Oxygenation 210Michael Piagnerelli Ann Dierick & Philippe Van der Linden 19 Tissue Oxygenation and Blood Transfusion 218Stefan Suttner & Joachim Boldt 20 Anemia and Cardiovascular Disease 229Antonis S. Manolis Spyridon Koulouris Kostas Triantafyllou Dimitris Sakellariou Sokratis Pastromas & Helen Melita Part 5 Perioperative Hemostasis 253 21 Monitoring of Hemostasis in the Perioperative Setting 255Sibylle A. Kozek-Langenecker & Eva Schaden 22 Antifibrinolytics in Open-Heart Surgery 267Wulf Dietrich 23 Efficacy and Safety of Recombinant Activated Factor VII to Control Bleeding in Nonhemophiliac Patients 278Jean-François Hardy Sylvain Bélisle & Philippe Van der Linden Part 6 Transfusion Triggers 293 24 Role of Hemoglobin/Hematocrit 295Kristine J. Guleserian Hae W. Kim Bruce Pearce Arkadiy Pitman & A. Gerson Greenburg 25 Calculation of Blood Loss 303Mark E. Brecher 26 Management of Massive Transfusion 313Jean-François Hardy & Marc Samama Part 7 Alternatives to Allogeneic Blood Transfusion 329 Section 1 Pharmaceutical Approaches 331 27 Iron Deficiency: Causes Diagnosis and Management 335Manuel Muñoz José Antonio García-Erce & Elvira Bisbe 28 Current Status of Perisurgical Erythropoietin Therapy 350Lawrence T. Goodnough 29 Erythropoietin and Iron Therapy in Patients with Renal Failure 357Lucia Del Vecchio & Francesco Locatelli 30 Hemoglobin-based Blood Substitutes 368G. Deby-Dupont Bernadette Remy & Maurice Lamy 31 Perfluorocarbon Emulsions 380Pedro Cabrales Section 2 Surgical Techniques 389 32 Minimally Invasive Cardiac Surgery: Impact on Blood Loss and Transfusion 391He Tao & Fraser Rubens 33 Adjunctive Strategies to Impact Blood Transfusion in Cardiac Surgery 408L. Ressler & Fraser Rubens Section 3 Anesthetic Techniques 419 34 Anesthetic Techniques to Reduce Blood Loss 421Dafydd Thomas 35 Controlled Hypotension Decreases Blood Transfusion Requirement: Fact or Fallacy? 430Richard P. Dutton 36 Acute Normovolemic Hemodilution 439Javad Bidgoli & Philippe Van der Linden 37 Hyperoxic Hemodilution 450Jens Meier Konrad Messmer & Oliver Habler 38 Intraoperative and Postoperative Cell Salvage 458Ernil Hansen & Hans Gombotz Section 4 Special Settings 475 39 Anemia and Red Blood Transfusion in Critical Care 477Tim Walsh 40 Red Blood Cell Transfusions and Alternatives to Treat the Anemia of Prematurity 490Ronald G. Strauss 41 Transfusion Alternatives in Orthopedic Surgery 498Manuel Muñoz José Antonio García-Erce & Jorge Cuenca 42 Transfusion Alternatives in Obstetrics 509Christian Breymann Part 8 Legal and Ethical Issues in Transfusion Medicine 521 43 Ethical Aspects of Informed Consent: American Models 523Ronald E. Domen 44 Blood Transfusions Jehovah’s Witnesses and the American Patients’ Rights Movement 531Charles H. Baron Part 9 Cost Issues 557 45 The Cost and Cost-Effectiveness of Allogeneic and Autologous Blood 559Brian Custer 46 Autologous Blood Predonation in Cardiac Surgery 569Wulf Dietrich 47 Cost-Effectiveness of Pharmacological Alternatives 575Dean Fergusson & Brian Hutton Index 581
£123.26
John Wiley and Sons Ltd Haematology Nursing
Book SynopsisHaematology Nursing is a comprehensive handbook, with a nursing focus, on the care and management of patients with haematological disorders. Divided into four sections, the first provides an introduction to haematology, looking at haemopoiesis, immunology and genetics.Table of ContentsContributors vii Foreword x Section 1 Introduction to Haematology 1 1 Understanding Haemopoiesis 3 Marvelle Brown 2 Immunology 22 Jane Richardson and Tracey Cutler 3 Genes and Haematology 37 Gwyneth Morgan 4 The Cell 50 Louise Knight Section 2 Non-Malignant Haematology 61 Anaemia 5 Aplastic Anaemia: Pathophysiology, Care and Management 63 Audrey Yandle 6 Nutritional Anaemia: Pathophysiology, Care and Management 79 Marvelle Brown 7 Acquired Haemolytic Anaemia: Pathophysiology, Care and Management 96 Marvelle Brown 8 Inherited Haemolytic Anaemia: Pathophysiology, Care and Management 107 Marvelle Brown Haemoglobinopathies 9 Sickle Cell Disease and Thalassaemia: Pathophysiology, Care and Management 117 Marvelle Brown Haemochromatosis 10 Haemochromatosis: Pathophysiology, Care and Management 150 Jan Green Section 3 Myeloproliferative and Lymphoproliferative Disorders 163 11 Polycythaemia: Pathophysiology, Care and Management 165 Marvelle Brown 12 The Myelodysplastic Syndromes: Pathophysiology, Care and Management 171 Jackie Green 13 Acute Leukaemia: Pathophysiology, Care and Management 183 Jackie Green 14 Chronic Leukaemia: Pathophysiology, Care and Management 195 Samantha Toland 15 Multiple Myeloma: Pathophysiology, Care and Management 202 Marvelle Brown 16 Lymphoma: Pathophysiology, Care and Management 217 Tracey Cutler Section 4 Nursing Care Interventions 233 17 Blood Transfusion 235 Jan Green 18 Venous Access Devices 261 Janice Gabriel 19 Chemotherapy and Monoclonal Antibodies 275 Alison Simons and Tracey Cutler 20 Haemopoietic Stem Cell Transplant 287 Tracey Cutler 21 Palliative Care in Haematology 300 Dion Smyth Glossary of Terms 314 Index 317
£37.95
John Wiley and Sons Ltd Atlas of Comparative Diagnostic and Experimental
Book SynopsisA vital resource on blood and bone marrow cell morphology in laboratory animal medicine. This fully revised new edition is an essential reference for clinical pathologists in diagnostic laboratories, and medical or veterinary research. The atlas contains over 400 color images of cells from the peripheral blood and bone marrow from a variety of animals encountered in laboratory animal medicine, in health and disease. Key features: New chapter on flow cytometry and its application in terms of routine analyses as a means of identifying abnormalities in cell marker expression, which is of particular relevance for pre-clinical safety assessment Covers the most recent developments in laboratory animal hematology, including parameters measured by the latest generation of analyzers Coverage of a wide range of laboratory animal species, as well as those used in clinical veterinary trials Photomicrographs present normal and abnormal blood cells from a Trade Review“This book may not be useful for the typical veterinary student or practitioner, but it is an excellent resource for those involved in preclinical studies on toxicosis.” (Journal of The American Veterinary Medical Association, 15 June 2012) "A fine college reference!." (The Midwest Book Review, 1 November 2011)Table of ContentsForeword vii Introduction ix Dedication xi Acknowledgments xiii 1 Rodents 1 Mouse 1 Introduction 1 Blood picture 1 Typical ranges (Siemens Advia 120) 2 Hamster 15 Introduction 15 Blood picture 15 Guinea Pig 17 Introduction 17 Blood picture 17 Rat – Sprague Dawley (SD)/Han Wistar (HW) 18 Introduction 18 Blood picture 18 Typical ranges (Siemens Advia 120) 19 References 36 2 Rabbit 37 Introduction 37 Blood picture 37 References 39 4 Dog 45 Introduction 45 Blood picture 45 Typical ranges (Siemens Advia 120) 46 References 64 5 Monkey 65 Introduction 65 Blood picture 65 Marmoset 66 Cynomolgus 71 Introduction 71 Blood picture 71 Typical ranges (Siemens Advia 120) 72 Baboon 84 Rhesus Monkey 86 References 87 6 Other species 89 Pig 89 Introduction 89 Blood picture 89 Horse 91 Introduction 91 Blood picture 91 Goat and Sheep 94 Assorted Other Species 96 References 103 3 Cat 41 Introduction 41 Blood picture 41 References 44 7 Blood collection procedures 105 Common bleeding sites 105 Anticoagulants 105 Staining 105 8 Artifacts 107 Collection artifacts 107 Sample transport and storage 109 Anticoagulant 110 Storage artifacts 111 Blood smear preparation 113 Stain precipitate 113 References 114 9 Bone marrow 115 Introduction 115 Review of marrow sampling techniques 115 Recommended methods for marrow sampling 116 Preparation and staining of smears 118 Evaluation 119 Interpretation 119 References 120 10 Comparative applications in flow cytometry 121 Application of flow cytometry in comparative hematology 122 References 132 Index 135
£72.86
Johns Hopkins University Press Living with HHT
Book SynopsisThis guide is essential for health professionals seeking more information about this underdiagnosed disease.Trade ReviewThis book is an excellent basic overview of HHT. It describes the condition, the difficulties often found in diagnosis, current and potential future treatments, as well as emotional and social effects for both patients and their families along with coping strategies. Throughout, the ability to live well with knowledge and appropriate care is emphasized.—Jeffrey Pollak, MD, Katharine Henderson, MS, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, Journal of Radiology NursingTable of ContentsAcknowledgmentsIntroductionPart I1. Diagnosis2. The Trouble with Telangiectasias3. HHT's Hidden DangersPart II4. Taking Care of Yourself5. Taking Care of Your Family6. Beyond the FamilyPart III7. Frontiers in HHT ResearchNotesGlossaryResourcesIndex
£23.85
Johns Hopkins University Press The Breast Cancer Book
Book SynopsisA comprehensive, down-to-earth guide for anyone diagnosed with breast cancer. Being diagnosed with breast cancer can be scary and confusing. There are medical terms to learn, options to consider, and important decisions to make, all while trying to carry on with work, family, and life. The Breast Cancer Book can't reverse a diagnosis or make breast cancer disappear, but every page can inform and empower you or your loved ones, no matter where you are in the breast cancer experience. Written by three trusted expertsan oncologist, a breast surgeon, and a two-time breast cancer survivorthis multidisciplinary book walks you through everything you need to know about breast cancer so that you can make the best decisions about diagnosis, treatment, and follow-up care. In plain, easy-to-understand language that illuminates all the facets of this disease, the authors draw on their professional experience and the most current scientific knowledge to describe the risk factors for breast cancer;Trade ReviewThis book is written thoughtfully and empathetically and I would urge you to read it if you've received this frightening diagnosis.—Dr. Kathleen Thompson, author of From Both Ends of the Stethoscope:Getting through breast cancer – by a doctor who knows, Frost MagazineTable of ContentsList of TablesIntroduction A Message of HopePart One. Understanding Breast Cancer1. What Is Cancer?2. Breast Cancer Basics3. Demystifying Breast Cancer Risk4. Strategies to Reduce Your Risk of Developing Breast Cancer5. Hereditary Breast CancerPart Two. Finding Breast Cancer and Dealing with a Diagnosis6. Screening Tools and Technologies7. Making a Diagnosis8. After a Diagnosis: Charting a Course and Assembling Your TeamPart Three. Understanding Treatment Choices and Making Decisions9. Local Therapy: Breast Cancer Surgery10. Radiation Therapy11. Rebuilding Your Breasts after Mastectomy12. Treating Noninvasive Breast Cancer: Ductal Carcinoma In Situ13. Reducing the Risk of Recurrence: Systemic Therapies for Invasive Breast Cancer14. Cancer Again: Treating Local or Regional Recurrence15. Treating Metastatic Breast Cancer16. Considering Breast Cancer Clinical Trials17. Treating Less Common Types of Breast Cancers and Male Breast CancerPart Four. Finding Answers18. Managing Breast Cancer Treatment Side Effects19. Complementary, Integrative, and Alternative Medicine20. Meeting the Emotional Challenges of Breast Cancer21. Family Matters during and after Breast Cancer22. Insurance and Money Matters during Breast Cancer TreatmentPart Five. Moving On23. Supportive Care and Symptom Management for Women with Metastatic Breast Cancer24. Living Well beyond Cancer: Healthy Breast Cancer SurvivorshipResourcesGlossaryIndex
£46.35
Johns Hopkins University Press Living with Hereditary Cancer Risk
Book SynopsisThe most comprehensive guide available on hereditary cancers, from understanding risk, prevention, and genetic counseling and testing to treatment, quality of life, and more. Up to 10 percent of cancers are caused by inherited mutations in specific genes. Finding out that you or your loved ones may be at increased risk of developing cancer because of a genetic mutation raises a lot of questions: Is cancer inevitable? Is there anything I should do differently in my life? Will my children also be at higher risk of cancer? Should I have preemptive treatments or surgery? This comprehensive guide provides answers to these questions and more. Written by three passionate patient advocates, this book is a compilation of the trusted information and support provided for more than two decades by Facing Our Risk of Cancer Empowered (FORCE), the de facto voice of the hereditary cancer community. Combining the latest scientific research with national guidelines, expert advice, and compelling patieTable of ContentsList of TablesForeword, by Matthew Boland Yurgelun, MDIntroductionPart I. Understanding Cancer and Inherited Risk1. The Link between Genetics and CancerThe Basics of GeneticsGene Wear and Tear and Repair How Cancers Develop and Grow Most Cancers Aren't Caused by Inherited Mutations2. What's Swimming in Your Gene Pool?Hidden Risk in the Family TreePlotting Your Genetic Pedigree3. Signs of Hereditary CancerThe Value of Genetic Counseling Making Decisions about Testing Insurance CoveragePrivacy and Protection4. What Your Test Results Tell YouPositive, Negative, Maybe Making Sense of StatisticsYou Have a Mutation; Now What?Part II. Inherited Gene Mutations and the Cancers They Cause5. Introducing BRCA1 and BRCA2Who Inherits a BRCA Mutation?Signs of a BRCA MutationLevels of Risk6. Lynch Syndrome: Five Genes, One Hereditary SyndromeSigns of Lynch Syndrome in FamiliesLevels of Risk7. Other Genes That Are Linked to Inherited Cancer RiskLess Known, Less Studied Genes8. Breast Cancer BasicsSigns and SymptomsWhat Affects Breast Cancer Risk?Types of Breast Cancer9. Gynecologic CancersOvarian, Fallopian Tube, and Primary Peritoneal CancersEndometrial Cancers10. Gastrointestinal CancersColorectal CancerSmall Bowel CancerPancreatic CancerStomach CancerAnal Cancer11. Genitourinary CancersProstate CancerBladder, Ureter, and Renal Pelvis Cancers12. MelanomaMelanoma of the SkinOcular MelanomaPart III. Strategies for Risk Reduction and Early Detection13. Risk Management GuidelinesGuidelines for BRCA1 or BRCA2 Gene MutationsGuidelines for Lynch Syndrome Gene MutationsGuidelines for Mutations in Other Genes14. Early Detection Strategies for High-Risk PeopleThe Vocabulary of ScreeningSurveillance for Breast CancerSurveillance for Gynecologic CancersSurveillance for Gastrointestinal CancersSurveillance for Prostate and Other Genitourinary Cancers Surveillance for MelanomaScreening for Other Hereditary Cancers15. Medications That Reduce Cancer RiskRisk-Reducing Medications for Breast CancerRisk-Reducing Medications for Gynecologic CancersRisk-Reducing Medications for Colorectal Cancers16. Surgeries That Reduce Breast Cancer RiskMastectomy ProceduresBreast Reconstruction ChoicesSide Effects, Risks, and Recovery17. Surgeries That Reduce the Risk of Gynecologic CancersSalpingo-Oophorectomy to Reduce the Risk of Ovarian CancerHysterectomy to Reduce the Risk of Endometrial Cancer18. Surgeries That Reduce the Risk of Gastrointestinal CancersTotal and Segmental Colectomy to Reduce the Risk of Colon CancerTotal Gastrectomy to Reduce the Risk of Stomach Cancer19. Factors That Affect Cancer RiskNutrition, Weight, and Physical Activity Alcohol: An Unwise ChoiceSmoking and Tobacco ProductsOther Lifestyle and Behavioral Risk FactorsPart IV. Treatment Choices for Hereditary Cancers20. Identifying Tumor Characteristics That Inform Treatment ChoicesStaging and Grading CancerTargeted Approaches to TreatmentDNA Damage Repair Genes21. Treating Breast CancerCancer Type, Subtype, and StageBiomarker TestingGenetic TestingOptions for TreatmentFollow-Up Care22. Treating Gynecologic CancersOptions for Ovarian, Fallopian Tube, and Primary Peritoneal CancersOptions for Endometrial Cancer23. Treating Gastrointestinal CancersOptions for Colorectal CancerOptions for Pancreatic CancerOptions for Gastric Cancer24. Treating Genitourinary CancersOptions for Prostate CancerOptions for Bladder, Renal Pelvis, and Ureter Cancers25. Treating Melanoma Options for Melanoma in the SkinOptions for Ocular MelanomaPart V. Living with Inherited High Risk26. Regaining Sexual Health and IntimacyBody ImageCoping with PainReduced Sexual DesireErectile DysfunctionRebuilding Intimacy27. Effects of Prevention and Treatment on FertilityPreserving Fertility in WomenPreserving Fertility in MenOther Parenting Alternatives28. Managing MenopauseSymptoms of Early MenopauseReplacement HormonesLong-Term Side Effects29. Side Effects and Other Quality-of-Life IssuesSummarizing Side Effects by TreatmentManaging Immediate Side EffectsLong-Term Effects of Prevention and TreatmentPrevivorship, Survivorship, and Follow-Up CareEnd-of-Life Issues30. Making Difficult Decisions Start at the Beginning: Should You Be Tested?Decisions about Your Cancer RiskDecisions about TreatmentPrevention and Treatment Clinical TrialsDecision-Making in 15 Steps31. You Are Not AloneCreate a Support SystemFind Emotional StrengthPursue Financial ResourcesLook to the HorizonAcknowledgmentsGlossaryNotesResourcesIndex
£19.35
John Wiley & Sons 100 Questions Answers About Myeloma
£20.89
Cornell University Press Hematologies
Book SynopsisIn this ground-breaking account of the political economy and cultural meaning of blood in contemporary India, Jacob Copeman and Dwaipayan Banerjee examine how the giving and receiving of blood has shaped social and political life. Hematologies traces how the substance congeals political ideologies, biomedical rationalities, and activist practices.Using examples from anti-colonial appeals to blood sacrifice as a political philosophy to contemporary portraits of political leaders drawn with blood, from the use of the substance by Bhopali children as a material of activism to biomedical anxieties and aporias about the excess and lack of donation, Hematologies broaches how political life in India has been shaped through the use of blood and through contestations about blood. As such, the authors offer new entryways into thinking about politics and economy through a bloodscape of difference: different sovereignties; different proportionalities; and different temporalTable of ContentsAcknowledgments 1. Bloodscape of Difference 2. Sovereignty and Blood 3. Substantial Activisms 4. Hemo Economicus: From Blood Sacrifice to Blood Science? 5. The Broken World of Transfusion 6. Blood in the Time of the Civic 7. Hematic Futures Notes References Index
£20.89
Cognella, Inc Interpreting Arterial Blood Gases the Easy Way
Book SynopsisDeveloped specifically for student nurses and based on the author's over thirty years of teaching experience, Interpreting Arterial Blood Gases the Easy Way teaches students a step-by-step method for interpreting blood gases and helps them learn how to apply the interpretations.The booklet is divided into two parts. Part I teaches students to differentiate between acidic and alkaline states, identify respiratory or metabolic changes in blood gases, and recognize compensated, partially compensated, and uncompensated states. In Part II students apply what they have learned in order to recognize signs and symptoms of abnormal blood gases, identify appropriate interventions, and understand the meaning and significance of specific oxygenation levels.Clear and well-organized, the material features quizzes for self-evaluation, critical thinking questions, and tips that may assist with the National Council Licensure Examination. Knowledge of basic physiology and acid-base balance is recommended before using the booklet, but the information is also reviewed. Interpreting Arterial Blood Gases the Easy Way is an excellent choice for nursing programs. It can also be used in training respiratory therapists and emergency medical technicians.
£35.66
Springer International Publishing AG Nutritional Anemia
Book SynopsisUnderstanding the causes of anemia is critical to inform appropriate strategies to prevent and treat anemia, particularly to reduce the risk of anemia and the burden of disease. The strength of this book lies in its cross-disciplinary nature. This publication summarizes the current state of evidence on the multifactorial causes of anemia, with a specific focus on nutritional anemia. The chapter authors are leading experts in nutrition and global health. The introductory chapters provide an overview of the global burden of anemia prevalence, the economic implications and functional consequences of anemia, and the significance of these factors to guide policy and programs. Subsequent chapters provide current evidence on iron and other micronutrient metabolism and homeostasis in regards to anemia, the multifactorial contributors to anemia (e.g. infection and genetics), and the interactions between nutrients that may contribute to anemia. The summarizing chapters detail program and policy approaches to treat, prevent and reduce anemia in the global context. Nutritional Anemia is a comprehensive resource for those involved in global health and nutrition policy, strategy, programming, or research, and serves as a guide for how government, NGO, and international agencies can effectively treat, prevent and reduce anemia globally.Table of ContentsWorldwide Prevalence and Progress in Anemia Reduction.- The Economics of Addressing Nutritional Anemia.- Iron Biology: Metabolism and Homeostasis.- Laboratory Methods for Measurement of Anemia and Iron Status.- Interpretation of Biomarkers and Diagnosis of Nutritional Status.- Anemia and Iron Deficiency in Disease.- Nutritional Anemia in Special Population Groups (children, elderly, pregnancy/lactation, vegetarians).- Sources of Iron Intake: Diet, Supplemental, Environmental.- Bioavailability: Inhibitors and Enhancers of Iron Absorption.- Food Fortification with Iron: Policy and Considerations.- Genetic Hemoglobinopathies and their Contribution to Anemia.- Role of B-vitamins in Nutritional Anemia.- Oxidative Stress and Vitamin E in Anemia.- Vitamin D and Hepcidin in Nutritional Anemia.- Infection and Inflammation in the Etiology and Assessment of Iron Deficiency of Anemia.- Iron Infection and the Immune System.- Anemia in Sever Undernutrition (malnutrition).- Interactions between Iron and other Minerals in the Etiology of Anemia.- Iron and the Gut Microbiota.- An Overview of the Functional Significance of Iron Deficiency (Cognitive, Behavioral).- Designing Effective Programs for Anemia Prevention, Treatment, and Reduction.- Market-based Approaches for Anemia Prevention, Treatment, and Reduction.- Safety of Interventions to Reduce Nutritional Anemia.- Novel Approaches to Iron Supplementation.- Food-based Approaches to Combating Iron Deficiency.- Conclusions and Research Agenda.
£170.99
Springer International Publishing AG Patients’ Lived Experiences During the Transplant
Book SynopsisThe book was envisioned by bedside nurses caring for transplant and cellular therapy patients as a way to teach novice nurses and health care colleagues about the care required for this complex patient population. The nurse authors recruited an oncology nurse practitioner, transplant physician, nurse scientist and expert in medical humanities and health studies to join the project team. The dedication of the team and the willingness of the patients to contribute to the project, has led to a unique case study approach focused on the lived experience of patients and care partner(s) during the transplant/cellular therapy journey. The case studies are unique in that they encompass a qualitative narrative developed using Interpretive Phenomenological Analysis (IPA) and the inclusion of the individual's actual medical and nursing care from their health record. At every step along the trajectory of the illness, the medications and care received are described, interspersed with the voice of the patient and care partner(s) sharing their experiences. The chapters follow the individual patients and their care partner(s) through all phases of their illness. The interviews were conducted, and case studies written by the bedside clinical nurses. Visual art and prose created by patients and care partner(s)s are included in the chapters. The book also includes an introduction written by the nurse authors, a methods chapter on the inclusion of IPA in a case study, and poignant epilogue. The premise of nursing support for survivorship is woven throughout the book, highlighting how giving back aids in recovery identity.This book, full of beautiful artworks and poems, is the work of clinical nurses devoted to improving care for their patients by sharing the patient stories with others. It introduces a unique approach to the case study which could be replicated and applied to any diagnosis.Table of ContentsForeword by Susan K. Stewart, Executive Director of Blood and Marrow Transplant Information NetworkIntroduction Lisa Wesinger, RN, BSN, OCN, Judi Gentes, RN, ADN, Carissa Morton, RN, BSN,(5 pages)Creating a Patient-Centered Case Study, Jennifer Holl, DNP,RN, Jean Coffey PhD, APRN, FAAN (15 pages)Part A. The Autologous Stem Cell Transplant JourneyChapter 1. Hope and Determination by Lisa Wesinger, Judi Gentes, Carissa Morton and Jennifer Holl (18 pages)Chapter 2. The Hugger by Lisa Wesinger (13 pages)Chapter 3. Spaces in Between by Judi Gentes (8 pages) Part B. The Allogeneic Stem Cell Transplant JourneyChapter 4. Saving Superman by Sara Cooke (9 pages)Chapter 5. Brothers in Arms by Lisa Wesinger (10 pages)Chapter 6. Letting Go by Carissa Morton (7 pages)Chapter 7. Another Ode to August by Lisa Wesinger (10 pages)Chapter 8. Dr’s Orders by Ashley Prokopik (TBD)Chapter 9. Am I Dreaming by Judi Gentes (9 pages)Chapter 10. With Every Sunrise I’ll Do Better by Sara Cooke (7 pages) Part C. The CAR T-Cell JourneyChapter 11. Second Chances by Kate Caldon (TBD) Epilogue: Saying Goodbye, Lasting Reflections and New Horizons by John Hill (TBD)
£58.49
De Gruyter Smooth muscle and stromal tumors and prevention
Book SynopsisThe subject matter of volume 1 of the 2-volumes-handbook focusses on leiomyosarcoma, low-grade and high-grade endometrial sarcoma and undifferentiated uterine sarcoma of the whole female genitalia. A separate extensive chapter is devoted to the variants of leiomyoma (angio-, lipo-, cotyledonoid, cellular, mitotically active, epithelioid and myxoid leiomyoma, leiomyoma with bizarre nuclei), atypical smooth muscle tumors (smooth muscle tumors with uncertain malignant potential), and disseminated peritoneal leiomyomatosis, benign metastasizing leiomyoma, and intravenous leiomyomatosis. Furthermore, endometrial stromal tumors – endometrial stromal nodules, endometrial stromal tumor with sex cord-like elements (ESTSCLE), uterine tumor resembling ovarian sex-cord tumor (UTROSCT) - and similar tumors are described in detail. The book provides a description at length of the epidemiology, etiology, pathological anatomy, prognosis, diagnosis, differential diagnosis, imaging and comprehensive therapy of each primary, relapsed, and metastasized tumor including surgery, chemo-, hormone- and radio- and targeted therapy. Another chapter is devoted to the prevention of subjecting sarcomas to inadequate surgical therapeutic measures under the assumed diagnosis of leiomyoma, and includes a diagnostic-therapeutic flowchart with a diagnostic score. The book aims to identify and provide diagnostic and therapeutic guidance. The listed tumor entities also constitute a particular diagnostic challenge for pathologists that contains numerous pitfalls and difficulties. This book, therefore, addresses gynecologists and pathologists in both clinical and private practice, but also surgeons and hemato-oncologists.
£147.15
Springer International Publishing AG Laboratory Hemostasis: A Practical Guide for
Book SynopsisCoagulation testing is the basis for the diagnosis of bleeding and thrombotic disorders, as well as the mainstay of anticoagulant monitoring and management. This handbook provides practical information and guidance on topics relevant to directing a coagulation laboratory, filling a void in the literature. Since the first edition, all chapters have been updated and an entirely new chapter is included on pharmacogenomics and pharmacogenetics. The book will aid pathologists, clinical laboratory scientists and other physicians serving as laboratory directors to understand and carry out their responsibilities. It will also assist residents and fellows in learning the basics of coagulation testing and serve as a useful day-to-day reference for coagulation laboratory supervisors, technologists, and technicians. Finally, clinicians may find aspects of the book helpful in understanding the role of the coagulation laboratory in patient evaluation and monitoring.Trade ReviewFrom the book reviews:“The purpose is to provide a single reference with information and guidance related to directing a clinical coagulation laboratory. The book is intended for everyone involved in clinical coagulation testing -- residents and fellows, clinical laboratory scientists, pathologists, or doctoral level scientists involved in directing a clinical coagulation laboratory. It would also be of interest to ‘users’ -- e.g., clinical hematology consultants. … This is a must-have for any clinical coagulation laboratory director.” (Valerie L. Ng, Doody’s Book Reviews, January, 2015)Table of ContentsRole and Responsibilities of the Laboratory Director.- Collection of Coagulation Specimens.- Instrumentation for the Coagulation Laboratory.- Validation of Coagulation Assays, Instruments and Reagents.- Hemostasis Screening Assays.- Testing for Inherited Bleeding Disorders.- Testing for Acquired Platelet Disorders.- Acquired Coagulation Disorders and TTP.- Testing for Inherited and Acquired Thrombotic Disorders.- Monitoring of Anticoagulant Therapy.- Pharmacogenomics and Pharmacogenetics.- Coagulation Testing and Transfusion Medicine.
£75.99
Taylor & Francis Ltd Essential Paediatric Haematology
a huge range and FREE tracked UK delivery on ALL orders.
£37.04
Taylor & Francis Ltd Hematopoietic Stem Cell Transplantation
a huge range and FREE tracked UK delivery on ALL orders.
£56.99
Cambridge University Press The Hemopoietic ColonyStimulating Factors
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£73.14
Cambridge University Press Diagnostic Techniques in Hematological Malignancies
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£83.59
Cambridge University Press Blood Stem Cell Transplants
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£25.64
Cambridge University Press Myelodysplastic Syndromes
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£39.89
Cambridge University Press Transfusion Microbiology Cambridge Medicine Hardcover
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£111.15
Cambridge University Press Hemopoietic ColonyStimulating Factors
a huge range and FREE tracked UK delivery on ALL orders.
£128.25
Cambridge University Press Treatment of Multiple Myeloma and Related Disorders
a huge range and FREE tracked UK delivery on ALL orders.
£82.64
Cambridge University Press Hematological Complications in Obstetrics Pregnancy and Gynecology
a huge range and FREE tracked UK delivery on ALL orders.
£181.45
Cambridge University Press Hematopathology and Coagulation
Book SynopsisA comprehensive series of multiple-choice questions and answers to help readers strengthen their knowledge of hematopathology and coagulation to prepare for their American Board of Pathology exams. All areas of the curriculum, from red blood cell count and coagulation disorders to hematopoietic neoplasms, are covered, and explanations are given to aid learning.Table of ContentsPreface; Part I. Non Neoplastic Hematology: 1. RBC disorders; Answers to chapter 1; Answers to chapter 1 (with explanations); 2. Non neoplastic WBC and platelet disorders; Answers to chapter 2; Answers to chapter 2 (with explanations); 3. Benign lymph node; Answers to chapter 3; Answers to chapter 3 (with explanations); Part II. Hematopoietic Neoplasms: 4. Myeloid neoplasms; Answers to chapter 4; Answers to chapter 4 (with explanations); 5. Mature B cell lymphomas, plasma cell neoplasms and Hodgkin lymphoma; Answers to chapter 5; Answers to chapter 5 (with explanations); 6. Mature T cell and NK cell neoplasms; Answers to chapter 6; Answers to chapter 6 (with explanations); Part III. Haemostasis and Coagulopathy: 7. Coagulation disorders; Answers to chapter 7; Answers to chapter 7 (with explanations).
£57.13
John Wiley and Sons Ltd Hemophilia and Hemostasis
Book SynopsisThere is a general need amongst healthcare professionals for practical advice on the management of patients with bleeding disorders. This book is an essential resource for all those working in the fields of coagulation, hemostasis and thrombosis. It covers the major cases one might encounter in diagnosing, managing and treating hemophilia and hemostasis. It provides a practical and informative guide to the broad range of topics concerning both bleeding and clotting disorders. The book is divided into major chapter sections depending on the type of bleeding disorder it fits into. Each chapter includes a brief overview of the disorder covering: history of the disorder; molecular basis of the disorder; class presentation; genetics; current laboratory tests and monitoring. Cases associated with each disorder are presented alongside practical questions and answers from a wide range of contributors. As practice can vary from center to center, controversial areas are clearly marked Trade Review“Overall, this is an extremely well written book suitable for consultants, trainees and, postgraduates, and is a must for all medical college libraries.” (Indian Journal Medical Research, 1 September 2013) “This is an important book, as there are not many on the management of hemophilia and hemostasis that use a structured, case-based approach.” (Doody’s, 26 July 2013) “On the whole this book is a useful tool for daily practice, particularly for those planning to work outside of a haemophilia comprehensive care centre, where regular exposure to haemophilia is limited.” (Haem Trainee, 1 April 2013)Table of ContentsList of Contributors Foreword SECTION 1: HAEMOPHILIA A AND HAEMOPHILIA B General Overview The hemophilic ankle: an update The haemophilic knee: An update Haemophilia with Inhibitors Inhibitor patient requiring high dose therapy with rVIIa as well as sequential therapy with FEIBA. Prophylactic therapy in a patient with a high titer inhibitor Immune Tolerance Induction Monitoring during ITI FIX inhibitors Severe Hemophilia B with high response inhibitor and anaphylactic reaction to factor IX Inhibitor patient and dental surgery Haemophilic treatment for procedures DVT prophylaxis in patients with hemophilia A undergoing orthopedic surgery Prostate Surgery and Hemophilia Mild Hemophilia and Intraocular Injections Endoscopy/colonoscopy and Hemophilia Dialysis and Hemophilia Circumcision PK Studies prior to Orthopedic Surgery Compartment Syndrome Successful eradication of factor VIII inhibitor in patient with mild Hemophilia A prior to hemipelvectomy for extensive hemophilic pseudotumor Coronary artery disease and hemophilia Valve Replacement and Hemophilia Treatment for other conditions Thyroid biopsy and Hemophilia Atrial Fibrillation and bleeding disorders Chronic Upper GI bleeding and hemophilia Hematuria Other issues in haemophilia care Reproductive Options for Hemophilia A Carriers Mild Hemophilia A with Discrepant FVIII activity levels Compund Diagnoses Hemophilia A with tuberous sclerosis and CNS bleed Familial Risk Assessment for Individuals with Hemophilia A and von Willebrand Disease Hemophilia A and HHT SECTION 2: VON WILLEBRAND DISEASE Management during procedures Type I VWD Tonsillectomy VWD and Dental surgery VWD and GI surgery VWD and Obstetric/Gynecologic Procedures Rare forms of Von Willebrand Disease Type 2A VWD and recurrent GI bleeding Type 2B VWD and Thoracic Surgery Von Willebrand disease 2N SECTION 3: OTHER BLEEDING DISORDERS Prothrombin deficiency Factor V deficiency Factor VII deficiency FX deficiency Factor XI deficiency Factor XIII deficiency Combined factor V and factor VIII deficiency 1, 2 Glanzmann Thrombaesthenia Gardner-Diamond syndrome and VWD Qualitative Platelet Disorder—QPD SECTION 4: ACQUIRED BLEEDING DISORDERS Acquired FVIII inhibitor and B cell neoplasm FVIII inhibitor and lupus inhibitor Acquired VWD A woman with bleeding gums Bleeding after cardiac surgery Bleeding in a dialysis patient A woman with anemia and hematuria Scalp bleeding in an older gentleman Hyperfibrinolysis SECTION 5: THROMBOTIC DISORDERS Heparin induced thrombocytopenia with thrombosis Heparin Skin Necrosis Warfarin skin necrosis Thoracic outlet syndrome 3, 4 Antithrombin Deficiency May-Thurner syndrome Thrombosis in a liver transplant patient Combined thrombophilia Index
£79.75
John Wiley and Sons Ltd Basics of Blood Management
Book SynopsisTo reduce transfusion-related morbidity and mortality, it is recommended that an integrated approach to blood management is employed using all available tools to reduce a patient's exposure to donor blood.Trade Review“This is a valuable guide if you are interested in setting up a blood management program for your organization.” (Doody’s, 15 February 2013)Table of ContentsPreface, vii Preface to the First Edition, viii 1 History and Organization of Blood Management, 1 2 Physiology of Anemia and Oxygen Transport, 9 3 Anemia Therapy I: Erythropoiesis-Stimulating Agents, 21 4 Anemia Therapy II: Hematinics, 36 5 Growth Factors, 51 6 Fluid Management, 67 7 Chemistry of Hemostasis, 81 8 Recombinant Blood Products, 100 9 Artificial Blood, 109 10 Oxygen Therapy, 124 11 Preparation of the Patient for Surgery, 139 12 Iatrogenic Blood Loss, 160 13 Physical Methods of Hemostasis, 173 14 Anesthesia—More than Sleeping, 191 15 Use of Autologous Blood, 201 16 Cell Salvage, 212 17 Blood-Derived Pharmaceuticals, 229 18 Transfusion Medicine, 245 19 Step by Step to an Organized Blood Management Program, 262 20 Law, Ethics, Religion, and Blood Management, 285 Appendix A: Detailed Information, 297 Appendix B: Sources of Information for Blood Management, 305 Appendix C: Program Tools and Forms, 309 Appendix D: Teaching Aids: Research and Projects, 323 Index, 327
£84.50
American College of Physicians Home Care Guide for Cancer American College of
Book SynopsisThis [is a] concise, jargon-proofed, user-friendly volume."-Journal of the American Medical AssociationTrade ReviewA valuable resource for any cancer caregiver involved with home care... The mundane, the scary, and the technical are covered with practicality and aplomb. All chapters direct the acquisition of skills that lead to successful coping... This [is a] concise, jargon-proofed, user-friendly volume. Journal of the American Medical AssociationTable of ContentsChapter 1. Solving Problems Using the Home Care Guide for CancerChapter 2. Succeeding at CaregivingChapter 3. Fever and InfectionsChapter 4. Tiredness and FatigueChapter 5. Problems with AppetiteChapter 6. Problems with the MouthChapter 7. Nausea and VomitingChapter 8. DiarrheaChapter 9. ConstipationChapter 10. Cancer PainChapter 11. Problems with VeinsChapter 12. Problems with BleedingChapter 13. Skin Problems Chapter 14. Hair LossChapter 15. Sexual ProblemsChapter 16. Maintaining Positive ExperiencesChapter 17. Getting Companionship and Support from Family and FriendsChapter 18. Problems with Getting Information From Medical StaffChapter 19. Getting Help from Community Agencies and Volunteer GroupsChapter 20. Moving Around the House Chapter 21. Coordinating Care From One Treatment Setting to AnotherChapter 22. Coping With AnxietyChapter 23. Coping With DepressionIndex
£23.75
£24.79
John Wiley and Sons Ltd Textbook of Hemophilia
Book SynopsisTextbook of Hemophilia, 3rd edition Edited by Christine A. Lee, MA, MD, DSc, FRCP, FRCPath, FRCOG Emeritus Professor of Haemophilia, University of London, London, UK Erik E. Berntorp, MD, PhD Professor of Coagulation Medicine, Lund University Malmö Centre for Thrombosis and Haemostasis, Skåne University Hospital, Malmö, Sweden W. Keith Hoots, MD Director, Division of Blood Diseases and Resources, National Heart, Lung and Blood Institute National Institutes of Health, Bethesda, MD; Professor of Pediatrics and Internal Medicine, University of Texas Medical School at Houston, Houston, TX, USA Without doubt, Textbook of Hemophilia, 3rd edition is the definitive reference source on all aspects of haemophilia including diagnosis, management and treatment. Edited by three, world-renowned experts on haemophilia, this completely revised resource features chapters wriTable of ContentsContributors ix Historical introduction xv Christine A. Lee Part I: Introduction 1 Overview of hemostasis 3 Kathleen Brummel Ziedins and Kenneth G. Mann 2 Cellular processing of factor VIII and factor IX 9 Michael U. Callaghan and Randal J. Kaufman Part II: Hemophilia A 3 Molecular basis of hemophilia A 23 Geoffrey Kemball-Cook and Keith Gomez 4 Prophylaxis 33 Kathelijn Fischer and H. Marijke van den Berg Part III: Inhibitors to Factor VIII 5 Inhibitors to factor VIII: immunology 43 Jean-Marie R. Saint-Remy and Marc G. Jacquemin 6 Genetic and Environmental Risk Factors for Factor VIII inhibitor development 48 Jan Astermark 7 Epidemiology of inhibitors in hemophilia 53 Alfonso Iorio 8 Inhibitors to factor VIII: mild and moderate hemophilia 59 Kathelijne Peerlinck and Marc Jacquemin 9 Inhibitors to factor VIII/IX: immune tolerance 64 Donna M. DiMichele 10 Prophylaxis in inhibitor patients 72 Alessandro Gringeri 11 Inhibitors to factor VIII: treatment of acute bleeds 78 Claude Negrier Part IV: Acquired Hemophilia 12 Acquired inhibitors to factor VIII 87 Craig M. Kessler Part V: Hemophilia B 13 Hemophilia B: molecular basis 97 Keith Gomez and Pratima Chowdary 14 Factor IX inhibitors in hemophilia B 103 Meera B. Chitlur and Jeanne M. Lusher 15 Treatment of inhibitors in hemophilia B 107 Anand Tandra and Amy D. Shapiro Part VI: Pharmacokinetics of Factors VIII and IX 16 Pharmacokinetics 117 Sven Björkman 17 Individualized dosing 123 Peter W. Collins Part VII: Hemophilia: Birth to Old Age 18 Neonate with hemophilia 131 Angela E. Thomas and Elizabeth A. Chalmers 19 Work-up of a bleeding child 138 Manuel D. Carcao and Victor S. Blanchette 20 Care of the child with hemophilia 145 Rolf C.R. Ljung 21 Hemophilia in adolescence 150 Pia Petrini 22 Old age medicine and hemophilia 154 Evelien P. Mauser-Bunschoten and Roger E.G. Schutgens Part VIII: Products Used to Treat Hemophilia 23 Products used to treat hemophilia: recombinant products 165 Midori Shima and Akira Yoshioka 24 Products used to treat hemophilia: plasma-derived coagulation factor concentrates 174 Paul L.F. Giangrande 25 Products used to treat hemophilia: dosing 180 Miguel A. Escobar 26 Products used to treat hemophilia: regulation 185 Albert Farrugia 27 New drugs in the pipeline: from concept to clinic 192 Leonard A. Valentino Part IX: Surgical management 28 General surgical management of patients with hemophilia 199 Cindy Leissinger and Rebecca Kruse-Jarres 29 Continuous infusion of coagulation products in hemophilia 204 Angelika Batorova and Uri Martinowitz 30 Surgery in inhibitor patients 213 Pål Andrè Holme Part X: Musculoskeletal 31 Joint replacement in patients with hemophilia 221 Nicholas Goddard 32 Medical synovectomy (synoviorthesis) in hemophilia: radiosynovectomy and chemical synovectomy 228 E. Carlos Rodriguez-Merchan 33 Pseudotumors in patients with hemophilia 233 Michael Heim and Uri Martinowitz 34 Imaging modalities for assessment of hemophilic arthropathy 237 Andrea S. Doria and Björn Lundin 35 Physiotherapy in the management of hemophilia 247 Sébastien Lobet and David Stephensen 36 Outcome assessment in hemophilia 253 Pradeep M. Poonnoose and Alok Srivastava Part XI: Transfusion-transmitted Disease 37 Viral hepatitis and hemophilia 265 Michael Makris and Geoffrey Dusheiko 38 Transfusion-transmitted disease: emerging infections 272 Thomas R. Kreil 39 vCJD and hemophilia 277 Carolyn M. Millar Part XII: Gene Therapy 40 Hemophilia gene therapy: an overview 285 David Lillicrap 41 Gene therapy trials in hemophilia A and B 291 Katherine A. High 42 Gene therapy: molecular engineering of factor VIII and factor IX 298 Sundar R. Selvaraj and Steven W. Pipe Part XIII: Laboratory 43 Laboratory and quality control of assays 311 Steve Kitchen 44 Standardization of assays in hemophilia 318 Sanj Raut and Trevor W. Barrowcliffe 45 Global laboratory assays in hemophilia 328 Benny Sørensen and Guy Young Part XIV: Women and Bleeding Disorders 46 Obstetrics and gynecology: hemophilia 337 Rezan A. Kadir and Christine A. Lee 47 Women and von Willebrand disease 345 Peter A. Kouides Part XV: von Willebrand Disease 48 von Willebrand disease: molecular aspects 355 Daniel Hampshire and Anne Goodeve 49 von Willebrand disease: epidemiology 362 Francesco Rodeghiero and Giancarlo Castaman 50 von Willebrand disease: biological diagnosis 370 Veronica H. Flood and Robert R. Montgomery 51 Classification and clinical aspects of von Willebrand disease 377 Augusto B. Federici 52 Treatment of von Willebrand disease: desmopressin 386 Pier M. Mannucci 53 Treatment of von Willebrand disease: therapeutic concentrates 390 Erik E. Berntorp Part XVI: Rare Bleeding Disorders 54 Factor II 399 Jan Astermark 55 Factor V and combined factor V and VIII deficiencies 403 Flora Peyvandi and Marzia Menegatti 56 Congenital factor VII deficiency 413 Angelika Batorova 57 Factor X and factor X deficiency 421 David J. Perry 58 Factor XI deficiency 428 Paula H.B. Bolton-Maggs and Uri Seligsohn 59 Factor XIII deficiency 436 Diane Nugent and Loan Hsieh 60 Fibrinogen deficiency 445 Michael Laffan 61 Miscellaneous rare bleeding disorders 452 Frederico Xavier and Amy D. Shapiro Part XVII: Emergency Medicine 62 Emergency management of hemophilia 463 W. Keith Hoots Part XVIII: Evaluation of Hemophilia 63 Clinical trials and other methodologies 473 Sharyne M. Donfield and Alice E. Lail 64 Quality of life in hemophilia 478 Sylvia von Mackensen and Alessandro Gringeri 65 The economics of hemophilia treatment 489 Katarina Steen Carlsson and Erik E. Berntorp Part XIX: Comprehensive Care and Delivery of Care 66 Hemophilia databases 497 Charles R.M. Hay 67 Comprehensive care and delivery of care: the developed world 502 Christopher A. Ludlam and Cedric R.J.R. Hermans 68 Comprehensive care and delivery of care in hemophilia: the developing world 508 Alok Srivastava and Auro Viswabandya 69 Comprehensive care and delivery of care: the global perspective 515 Mark W. Skinner and Alison M. Street Index 523 Color plate section can be found facing page 202
£169.95
John Wiley and Sons Ltd Clinical Guide to Transplantation in Lymphoma
Book SynopsisA clinical guide to transplantation in lymphoma to present advanced knowledge on how to integrate, transplantat and other novel therapies in patients with lymphoid malignancies. It provides practical management guidance on how to integrate, transplant and other novel therapies in patients with lymphoid malignancies.Trade ReviewSir William Osler is reputed to have said, “Listen to the patient and he will give you the answer.” Had he been alive now and practicing transplantation for lymphoma, he could have well said “Read the Clinical Guide to Transplantation in Lymphoma and it will give you the answer.” These reviewers are very impressed by the breadth and scope of this book edited by Drs. Bipin Savani and Mohamed Mohty, ably aided by an array of expert contributors from all over the world.Clinical Guide to Transplantation in Lymphoma is extremely easy to read and very well written. In this era ofexponential information growth this book is surprisingly current, with the latest references. It has an ambitious scope, setting out to cover all aspects of transplantation in lymphoma and managing to meet that expectation.Chapters are laid out in logical sequence divided into 2 sections. Section 1 is particularly interesting and haschapters on the historical perspective of transplantation for lymphoma, transplant data collection and reporting, and analytical methods. The remainder of section 1 describes the general principles of transplantation in lymphomas, addressing issues such as mobilization, preparative regimens, and management of the early, late, and long-term issues arising after transplantation. Some chapters include transplantation for lymphoma in children, adults, and young adolescents; pretransplant evaluation; preparative regimens for autologous and allogeneic transplants; stem cell mobilization and stem cell source; post-transplant follow-up for autologousand allogeneic transplant, and a novel chapter, “First 100 Days of the Autologous Hematopoietic Stem Cell Transplantation Process in Lymphoma.” The chapters in section 1 are broadly applicable and would prove invaluable to trainees pursuing fellowships in hematopoietic cell transplantation.Section 2 is laid out as a chapter by chapter discussion of various lymphoma histologies and the applicability of hematopoietic cell transplantation in each. One can return to some of these chapters again and again because all common and most rare lymphoma subtypes (including HIV-associated lymphoma) are discussed in excellent detail. We found each one of these chapters to be remarkably up to date. In a field such ashematopoietic cell transplantation,where there is considerable ambiguity and few randomized studies, the authors and editors have maintained a neutral and unbiased tone,discussing the available data andguidelines exhaustively.Very few similar textbooks focus on transplantation in a disease group. Clinical Guide to Transplantation in Lymphoma is concise enough, practical, and clinically oriented to be considered a practical manual but at the same time manages to be comprehensive. Some unique features in this book are the numerous excellent graphs and tables and the discussion of case studies and clinical guidelines (United States and European) wherever applicable. We found very few typographic errors. For future editions we recommend at least 1 chapter devoted to the emerging field of cellular immunotherapy.The editors and the contributors need to be congratulated for an encyclopedic work that still manages to be a ready reference guide. This book will be used extensively and should be in the library of every transplanter.We hope it runs into many future editions and becomes the authoritative textbook for transplantation in lymphoma. (Yogesh Jethava, Parameswaran Hari, University of Arkansas for Medical Science, Biology of Blood and Marrow Transplantation, Nov 2015)Table of ContentsList of contributors vii Foreword xi Introduction 1 Section 1: Transplantation in lymphomas 1 Lymphoma and transplantation: historical perspective 5Andrew R. Rezvani 2 Lymphoma: working committee and data reporting after transplantation in lymphoma 13Wael Saber, Mehdi Hamadani, Shahrukh Hashmi and Parameswaran Hari 3 Use of transplantation in lymphoma: adults 23Parastoo Bahrami Dahi, Gabriela Soriano Hobbs and Miguel]Angel Perales 4 Hematopoietic stem cell transplantation for lymphoma in children, adolescents, and young adults 31Nader Kim El]Mallawany and Mitchell S. Cairo 5 Preparative regimens for lymphoma: autologous hematopoietic stem cell transplantation 45Taiga Nishihori, Karma Z. Salem, Ernesto Ayala and Mohamed A. Kharfan]Dabaja 6 Preparative regimens for lymphoma: allogeneic hematopoietic stem cell transplantation 57Mohamed A. Kharfan]Dabaja, Najla El]Jurdi, Mehdi Hamadani and Ernesto Ayala 7 Pretransplantation evaluation, comorbidities, and nondisease]related eligibility criteria for transplantation in lymphoma, 69Melissa Logue 8 Stem cell mobilization in lymphoma patients 75Tarah Ballinger, Bipin N. Savani and Mohamad Mohty 9 Allogeneic hematopoietic stem cell transplantation for lymphoma: stem cell source, donor, and HLA matching 85Michael Green and Mitchell Horwitz 10 Management of early and late toxicities of autologous hematopoietic stem cell transplantation 93Sai Ravi Pingali and Yago Nieto 11 Long]term follow]up of lymphoma patients after allogeneic hematopoietic cell transplantation 103Shylaja Mani and Navneet S. Majhail 12 First 100 days of the autologous hematopoietic stem cell transplantation process in lymphoma 109Angela Moreschi Woods 13 First 100 days of the allogeneic hematopoietic stem cell transplantation process in lymphoma 113Angela Moreschi Woods Section 2: Management 14 Stem cell transplantation in follicular lymphoma,119Satyajit Kosuri and Koen Van Besien 15 Chronic lymphocytic leukemia/small lymphocytic lymphoma 133Salyka Sengsayadeth and Wichai Chinratanalab 16 Diffuse large B]cell lymphoma 145Lauren Veltri, Bipin N. Savani, Mohamed A. Kharfan]Dabaja, Mehdi Hamadani and Abraham S. Kanate 17 Mantle cell lymphoma 161Sascha Dietrich and Peter Dreger 18 Hodgkin lymphoma 173Eva Domingo]Domenech and Anna Sureda 19 Peripheral T]cell lymphomas 187Giulia Perrone, Chiara De Philippis, Lucia Farina and Paolo Corradini 20 Transplantation in Burkitt and lymphoblastic lymphoma 201Gregory A. Hale 21 Transplantation in adult T]cell leukemia/lymphoma 209Ali Bazarbachi and Olivier Hermine 22 Hematopoietic cell transplantation for HIV]related lymphomas 217Joseph C. Alvarnas 23 Stem cell transplantation for mycosis fungoides/Sézary syndrome 233Eric D. Jacobsen 24 Role of transplantation in lymphoplasmacytic lymphoma 241Silvia Montoto and Charalampia Kyriakou 25 Transplantation outcome in primary mediastinal large B]cell lymphoma 247Amanda F. Cashen 26 Management of post]transplant lymphoproliferative disorders 253Jan Styczynski and Per Ljungman Appendix I Follow]up calendar after autologous stem cell transplantation in lymphoma 261Angela Moreschi Woods Appendix II Follow]up calendar after allogeneic stem cell transplantation in lymphoma 263Angela Moreschi Woods Index 265
£98.75
John Wiley and Sons Ltd Pediatric Hematology and Oncology
Book SynopsisThis new textbook has an international authorship and is a practical, up-to-date resource for clinicians responsible for the care of children with oncologic and malignant hematologic disease. Itis specifically designed for practicing oncologists and hematologists, pediatricians with an interest in childhood cancer and trainees seeking a systematic approach to these disorders. This new textbook has an emphasis on the visual presentation and ease of reading of contemporary and comprehensive information for children's cancers and contains detailed tables, fact boxes and illustrations. The textbook begins with an introduction to the general principles of the scientific foundation and treatment of childhood cancers and hematological malignancies. Separate sectionsare then devoted to descriptions of central nervous system tumors, hematological malignancies and solid tumors of childhood which encompass epidemiology, cellular and molecular biology, cancer genetics, immunology, pharmacologTrade Review“It is compact, concise, and easy to read and understand, and certainly a useful addition to the field.” (Doody's, 3 August 2012) "However, overall, this is a useful book, probably most useful for paediatricians who may be providing shared care for paediatric oncology patients, junior doctors on haematology/oncolgy ward." (The Bulletin of the Royal College of Pathologists, 1 July 2011)Table of ContentsContributors. 1 Introduction (Edward J. Estlin, Richard J. Gilbertson and Robert F. Wynn). Part I Central Nervous System Tumors of Childhood. 2 Low- and High-Grade Glioma (Ian F. Pollack). 3 Ependymoma (Thomas E. Merchant and Richard J. Gilbertson). 4 Embryonal Tumors (Amar Gajjar and Steven C. Clifford). 5 Pediatric Spinal Cord Tumors (Annie Huang, Ute Bartels and Eric Bouffet). 6 Pediatric Craniopharyngioma, Mixed Glioneuronal Tumors, and Atypical Teratoid/Rhabdoid Tumor (Adrienne Weeks and Michael D. Taylor). Part II Hematological Disorders. 7 Acute Lymphoblastic Leukemia (Robert F. Wynn). 8 Acute Myeloid Leukemia and Myelodysplastic Disorders (David K.H. Webb). 9 Non-Hodgkin’s Lymphoma (Angelo Rosolen and Lara Mussolin). 10 Hodgkin's Lymphoma (Wolfgang Dörffel and Dieter Körholz). 11 Histiocytic Disorders (Sheila Weitzman and R. Maarten Egeler). Part III Solid Tumors of Childhood. 12 Neuroblastoma (Sucheta J. Vaidya and Andrew D. J. Pearson). 13 Renal Tumors (Edward J. Estlin and Norbert Graf). 14 Soft Tissue Sarcoma (Gianni Bisogno and John Anderson). 15 Bone Tumors (Richard Gorlick, Martha Perisoglou and Jeremy Whelan). 16 Hepatic Tumors (Penelope Brock, Derek J. Roebuck and Jack Plaschkes). 17 Germ Cell Tumors (James Nicholson and Roger Palmer). 18 Retinoblastoma (Edward J. Estlin, François Doz and Michael Dyer). 19 Rare Tumors (Bernadette Brennan and Charles Stiller). Part IV Supportive Care, Long-Term Issues, and Palliative Care. 20 Supportive Care: Physical Consequences of Cancer and its Therapies (Bob Phillips and Roderick Skinner). 21 Psychosocial Needs of Children with Cancer and Their Families (Ged Lalor and Louise Talbot). 22 Late Effects in Relation to Childhood Cancer (Louise Talbot and Helen Spoudeas). 23 Palliative Care (Lynda Brook). 24 Clinical Trials Involving Children with Cancer – Organizational and Ethical Issues (Sue Ablett and Edward J. Estlin). Index. Colour plate.
£172.95
John Wiley and Sons Ltd Leukemias
Book SynopsisEdited by experts from one of the world's largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatments present an outlook for the future and explain the rationale for ongoing clinical trials. Topics include: Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, kit inhibitors, BCR-ABL inhibitors) Ras inhibitors Epigenetic therapy (hypomethylaters and histone deacetylase inhibitors) Lenalidomide analogs New chemotherapy drugs, e.g. clofarabine, cloretazine, sapacitabine, forodesine Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols in combination with dasatinib or imatinib) New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40) Thrombopoietic agents Leukemias: PrinciplTrade Review"This high quality book will be an excellent reference for both fellows and attending physicians who care for patients with leukemic disorders in either a community or academic setting . . . This book is a welcome resource for those entering the field as well as for long-time practitioners who want to stay up to date." (Doody's, 12 August 2011)Table of ContentsContributors. Preface. Part 1: Background and Diagnostic. 1. Stem Cell Biology in Normal and Malignant Hematopoiesis (Amer Zeidan and Meir Wetzler). 2. Epidemiology and Etiology of Leukemias (Andrew Fletcher, Annika Whittle and David Bowen). 3. Traditional Diagnostic Approaches (Hartmut Koeppen, Carlos E. Bueso-Ramos and Sergej N. Konoplev). 4. Diagnosis of Leukemias - New Diagnostic Modalities and Implications for Classification (Maher Albitar). 5. Non-cytogenetic Markers and Their Impact on Prognosis (Eric Schafer and Donald Small). Part 2: Myelodysplastic syndromes (MDS). 6. Myelodysplastic Syndromes: Pathophysiology (Steven D. Gore and Erica Warlick). 7. Myelodysplastic Syndromes - The Role of Cytogenetic and Molecular Abnormalities for Classification and Risk Assignment (Ulrich Germing). 8. Myelodysplastic Syndromes (William Stevenson and Guillermo Garcia-Manero). Part 3: Acute Myeloid Leukemia (AML). 9. Presentation and Diagnosis: Novel Molecular Markers and their Role in the Prognosis and Therapy of Acute Myeloid Leukemia (Wolfgang Kern, Torsten Haferlach, Susanne Schnittger, Claudia Haferlach, and Ulrike Bacher). 10. Induction Therapy of Acute Myeloid Leukemia (Martha Wadleigh and Daniel J. DeAngelo). 11. Salvage Therapy for Acute Myeloid Leukemia: Current Strategies and Emerging Therapies (Keith W. Pratz and Judith E. Karp). 12. Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia (Gheath Alatrash and Marcos de Lima). Part 4: Acute Promyelocytic Leukemia (APL). 13. The Pathophysiology of Acute Promyelocytic Leukemia (Francesco Lo-Coco and Syed Khizer Hasan). 14. Acute Promyelocytic Leukemia (APL): Manifestations and Therapy (Sylvain Thépot, Lionel Ades, Pierre Fenaux). Part 5: Acute Lymphoblastic Leukemia (ALL). 15. Acute Lymphoblastic Leukemia: Presentation, Diagnosis and Classification (Sandeep Gurbuxani and John Anastasi). 16. Induction Therapy in Adult Acute Lymphoblastic Leukemia (Xavier Thomas). 17. Salvage Therapy of Adult Acute Lymphoblastic Leukemia (Nicola Gökbuget and Dieter Hoelzer). 18. Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Current Treatment Status and Perspectives (Olga Sala-Torra and Jerald P. Radich). 19. Acute Lymphoblastic Leukemia in Adolescents and Young Adults (Michael E. Rytting). 20. The Role of Hematopoietic Stem Cell Transplantation in Adults with Acute Lymphoblastic Leukemia (Partow Kebriaei). Part 6: Chronic Myeloid Leukemia (CML). 21. Pathophysiology of Chronic Myeloid Leukemia (Agnes S. M. Yong and Junia V. Melo). 22. Therapy of Newly Diagnosed and Chronic Phase Chronic Myelogenous Leukemia (Andreas Hochhaus). 23. Therapy of Advanced Stage and Resistant Chronic Myeloid Leukemia (Devendra K. Hiwase and Timothy P. Hughes). Part 7: Chronic Lymphocytic Leukemia. 24. Chronic Lymphocytic Leukemia: Pathophysiology, Diagnosis and Manifestations, and Prognostic Markers (Thorsten Zenz, Hartmut Döhner, Stephan Stilgenbauer). 25. Therapy of Chronic Lymphocytic Leukemia – Frontline and Salvage (Valentin Goede, Barbara Eichhorst, and Michael Hallek). 26. The Role of Stem Cell Transplantation in Chronic Lymphocytic Leukemia (Simon Hallam and John G. Gribben). 27. Special Situations: Management of Elderly Patients and CLL Transformation (Wei-Gang Tong and Alessandra Ferrajoli). Part 8: Other Leukemic Disorders. 28. Hairy Cell Leukemia (Farhad Ravandi). 29. Therapeutic Approaches to the Mature T-cell Lymphoproliferative Leukaemias (Nnenna Osuji and Claire Dearden). 30. Philadelphia Chromosome Negative Myeloproliferative Neoplasms (Ruben A. Mesa and Srdan Verstovsek). Part 9: General Treatment Principles and Clinical Developments. 31. Management of Emergencies in Leukemias (Olga Frankfurt). 32. Management of Infectious Complications in Patients with Leukemia (Marcio Nucci, Nair Bijay and Elias Anaissie). 33. Transfusion Support and Hematopoietic Growth Factors (Paolo Rebulla). 34. New Designs for Clinical Trials: AML as an Example (Elihu Estey). Index. The color plate section.
£136.95
John Wiley and Sons Ltd Advances in Malignant Hematology
Book Synopsis* A comprehensive guide on recent developments in the molecular diagnosis and treatment of hematological malignancies * Contains practical information on current treatment strategies and covers future developments in the field * Fully illustrated .Trade Review"This book provides a concise overview of topics in malignant hematology. The charts and tables offer excellent, quick reviews of topics. In addition, the contributors appear to be well-respected authorities in the field." (Doody's, 2 September 2011) Table of ContentsPart 1: Hematopoiesis. 1 Normal and Malignant Hematopoiesis (Bijal D. Shah and Kenneth S. Zuckerman). 2 The Leukemic Genome (Jonathan C. Strefford and Nicholas CP Cross). Part 2: Myeloid Malignancies. 3 Myeloproliferative Neoplasms (Ruben A. Mesa and Ayalew Tefferi). 4 CML: Molecular Biology of BCR-Able (Javier I. Pinilla-Ibarz, Eric Padron and Lori Hazlehurst). 5 Standard Management of Patients with CML (Chronic Myeloid Leukemia) (Elias Jabbour, Jorge Cortes and Hagop Kantarjian). 6 The Molecular Biology of Acute Myeloid Leukemia (Jerald Radich). 7 Acute Myeloid Leukemia (Martin S. Tallman, Ritesh Parajuli and Jessica K. Altman). 8 Acute promyelocytic leukemia (APL) (Sylvain Thépot, Lionel Ades and Pierre Fenaux). 9 A Pluralistic approach to the study of myelodysplastic syndromes: Evolving pathology of the Seed via the Soil (Naomi Galili, Raymond Cruz, Jamie Stratton, Jessica Clima, Ghulam Sajjad Khan and Azra Raza). 10 Myelodysplastic Syndrome: A Review of Current Care (Kenneth H. Shain, Alan F. List and Rami S. Komrokji). 11 Supportive Care in Myelodysplastic Syndrome (MDS) (Hussain I. Saba, Arshia A. Dangol and Donald C. Doll). Part 3: Lymphoid Malignancies. 12 Molecular Biology of Chronic Lymphoproliferative Disorders (Monique A. Hartley and Lubomir Sokol). 13 Chronic Lymphocytic Leukemia (Terry Hamblin and Angela Hamblin). 14 Acute Lymphoblastic Leukemia (Susan O'Brien, Stefan Faderl, Deborah Thomas and Hagop M. Kantarjian). 15 Large Granular Lymphocyte Leukemia (Xin Liu and Thomas P. Loughran, Jr.). 16 Hairy Cell Leukemia (Kevin T. Kim, Darren S. Sigal and Alan Saven). 17 Molecular Basis of B-cell Lymphomas (Elizabeth M. Sagatys, Eduardo M. Sotomayor and Jianguo Tao). 18 Non-Hodgkin’s Lymphomas (Peter McLaughlin and Nathan Fowler). 19 Hodgkin Lymphoma (Michael Crump). Part 4: Plasma Cell Disorders. 20 Multiple Myeloma: Molecular Biology, Diagnosis and Treatment (S. Vincent Rajkumar and Shaji Kumar). 21 Waldenström’s Macroglobulinemia (Robert A. Kyle and Suzanne Hayman). 22 Primary Systemic (AL) Amyloidosis (Efstathios Kastritis and Meletios Athanasios Dimopoulos). Part 5: Bone Marrow Transplantation and Quality of Life. 23 Advances in allogeneic hematopoietic cell transplantation: progress in transplantation technology and disease-specific outcomes (Joseph Pidala and Claudio Anasetti). 24 Quality of Life after the diagnosis of Hematological Malignancies (Mohamed Sorror).
£118.70
