Genetics (non-medical) Books
Cambridge University Press The Origins of Native Americans Evidence from Anthropological Genetics
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£94.00
Cambridge University Press Primer of Genetic Analysis
Book SynopsisThis third edition of a student-tested study aid provides guided instruction in the analysis and interpretation of genetic principles and problem solving. All core areas of genetics are covered, and problems are provided to test understanding. It will complement any genetics textbook or stand alone as a review manual.Trade Review' … this is a clearly-written and well-organized book, which does an unassuming but important job.' The Times Higher Education Supplement'It is a book well worth having access to … ' Trends in Genetics'Any student dedicated enough to work through the problems is likely to benefit enormously and develop a greater conceptual understanding of genetics.' Animal GeneticsTable of Contents1. Overview of genetic organization and scale; 2. Mitosis and meiosis; 3. Nucleic acids: DNA and RNA; 4. Basic mendelian genetics; 5. Probability and chi-square; 6. Sex-linkage and gene interactions; 7. Pedigree analysis; 8. Overview of basic statistical testing; 9. Quantitative inheritance; 10. Overview of genetic mapping; 11. Assessing chromosome linkage relationships; 12. Linkage and mapping in diploids; 13. Mapping in bacteria and viruses; 14. Overview of types of genetic change; 15. Gene mutation; 16. Changes in chromosome number and structure; 17. Protein synthesis and the genetic code; 18. Gene regulation and development; 19. Overview of molecular biology techniques; 20. DNA mapping and human genome analysis; 21. Basic population genetics; 22. Selection and evolution; 23. Practice tests; 24. Answers to practice tests and crossword puzzles; 25. Landmarks in the history of genetics; Glossary; Reference tables.
£42.74
Cambridge University Press Prob Sol Biological Sequence Anly
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£42.74
Cambridge University Press The Thread of Life The Story of Genes and Genetic Engineering Canto
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£26.59
Cambridge University Press Genetics and Reductionism Cambridge Studies in Philosophy and Biology
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£35.14
Cambridge University Press The Genetic Inferno Inside the Seven Deadly Sins
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£80.09
Cambridge University Press Animal Traditions
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£118.75
Cambridge University Press Sex Ratios
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£46.54
Cambridge University Press Anthropology and the New Genetics
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£25.64
Cambridge University Press Population Genetics for Animal Conservation 17 Conservation Biology Series Number 17
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£52.24
Cambridge University Press Genomes Browsers and Databases Datamining Tools for Integrated Genomic Databases
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£40.84
Cambridge University Press Human Identity and Identification
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£24.99
Cambridge University Press Phylogenetic Networks Concepts Algorithms and Applications
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£56.99
Cambridge University Press Genetics Demography and Viability of Fragmented Populations
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£133.00
Cambridge University Press Genetics Demography and Viability of Fragmented Populations 4 Conservation Biology Series Number 4
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£60.79
Cambridge University Press Anatomy of Gene Regulation A ThreeDimensional Structural Analysis
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£72.19
Cambridge University Press The Evolution of Population Biology
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£123.50
Cambridge University Press The Human Genome Diversity Project An Ethnography of Scientific Practice Cambridge Studies in Society and the Life Sciences
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£78.00
Cambridge University Press Genes and the Agents of Life
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£71.25
Cambridge University Press The Epistemology of Development Evolution and Genetics
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£71.25
Cambridge University Press Singularities
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£60.79
Cambridge University Press Anthropology and the New Genetics New Departures in Anthropology
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£57.95
Cambridge University Press Population Genetics for Animal Conservation 17 Conservation Biology Series Number 17
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£89.30
Cambridge University Press Networks in Cell Biology
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£57.94
Cambridge University Press Chemical Genomics
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£96.90
Cambridge University Press Understanding Forensic DNA
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£11.99
Cambridge University Press Biophysics of DNA
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£35.14
Cambridge University Press Principles of Computational Modelling in Neuroscience
Book SynopsisTaking a step-by-step approach to modelling neurons and neural circuitry, this textbook teaches students how to use computational techniques to understand the nervous system at all levels, using case studies throughout to illustrate fundamental principles. Starting with a simple model of a neuron, the authors gradually introduce neuronal morphology, synapses, ion channels and intracellular signalling. This fully updated new edition contains additional examples and case studies on specific modelling techniques, suggestions on different ways to use this book, and new chapters covering plasticity, modelling extracellular influences on brain circuits, modelling experimental measurement processes, and choosing appropriate model structures and their parameters. The online resources offer exercises and simulation code that recreate many of the book''s figures, allowing students to practice as they learn. Requiring an elementary background in neuroscience and high-school mathematics, this is an ideal resource for a course on computational neuroscience.Trade Review'This new edition builds superbly on its predecessor. Expository excellence and beautifully clear figures remain, whilst extra material has been added throughout. New chapters cover critical topics such as modelling the way that neural signals are measured, and the details of model optimization and selection. Its impressive combination of depth and breadth makes the text perfect source material for a wide variety of courses.' Peter Dayan, Managing Director, Max-Planck Institute for Biological Cybernetics, Tuebingen'Principles of Computational Modelling in Neuroscience has long been my choice for my students from various backgrounds, but now it is even better! With the addition of comprehensive coverage for modelling extracellular activity, neural plasticity, and experimental stimulation and measurements, this text offers everything that my students need for a foundation in computational neuroscience. The new chapter on Model Section and Optimisation makes a difficult topic easy to understand. Principles of Computational Modelling in Neuroscience remains the best choice of a text that is rigorous but accessible to students from a variety of backgrounds.' Sharon Crook, Arizona State University'I am thrilled to endorse the second edition of Principles of Computational Modelling in Neuroscience. This comprehensive and well-written text is an engaging resource on the fundamentals of biophysical modelling and computational neuroscience. The range of topics and clarity of exposition provides a spectacular display of the power of computational techniques to provide insight into the mysteries of central nervous system function across its diverse hierarchical levels. This second edition contains many additional examples and new chapters on synaptic plasticity and learning, modelling of experimental measurements, as well as model selection and optimization. The authors have a remarkable ability to explain complex concepts in a clear and accessible manner, making this book an ideal choice for both students and researchers. The gradually increasing sophistication of each chapter makes it highly suited as a textbook for an introductory undergraduate course focusing on computational aspects of cell and systems neuroscience.' Greg Conradi Smith, William & Mary, Virginia and author of Cellular Biophysics and Modeling (Cambridge, 2019)'A valuable resource for both students and practitioners of computational modelling in neuroscience. The authors provide a step-by-step guide to modelling, from simple neurons to complex brain tissue. Each model is carefully explained and illustrated, put into context and critiqued. A definitive text for anyone wanting to develop their own models of neural circuitry!' Rosemary Fricker, Keele University Medical School; and Wolfson College, University of Cambridge'This textbook is useful for engineers, mathematicians, biologists and computer scientists. It provides a deep understanding of neuron computational modelling. The approach used, from ion channels to the new plasticity chapter, provides the student with a full picture of neural network behaviour. Furthermore, this new edition includes some cases of studies where the concepts are applied to real experimental data.' Fernando Perez-Peña, University of Cadiz'We have been using the book by Sterratt et al. for many years on our courses in theoretical neuroscience, to teach the basics of biophysics. The book does an excellent job of providing the basics in a highly understandable way for beginners in the field with lots of practical examples and additional background material for the implementation of models. The new edition of the book is even more useful since it integrates a lot of new material: nonlinear dynamics and bifurcations, neural field models, the modelling of measurement methods, and optimization. In addition, programming examples have been added, making the book even more useful for teaching.' Martin Giese, University of Tuebingen'This book is an invaluable resource for computational neuroscientists, particularly for students starting their doctoral research. The comprehensive coverage, clear prose and extensive examples make it easy for a newcomer with only basic background knowledge to get to grips with a wide variety of complex computational modelling topics as a preparation for starting their own investigations.' Abigail Morrison, RWTH Aachen UniversityTable of ContentsPreface; Acknowledgements; List of abbreviations 1. Introduction; 2. The basis of electrical activity in the neuron; 3. The Hodgkin–Huxley model of the action potential; 4. Models of active ion channels; 5. Modelling neurons over space and time; 6. Intracellular mechanisms; 7. The synapse; 8. Simplified models of the neuron; 9. Networks of neurons; 10. Brain tissue; 11. Plasticity; 12. Development of the nervous system; 13. Modelling measurements and stimulation; 14. Model selection and optimisation; 15. Farewell; References; Index.
£52.24
HarperCollins Publishers Inc The Language of Life DNA and the Revolution in
Book Synopsis
£16.14
McGraw-Hill Education - Europe Mader Biology 2016 12e Reinforced Binding Student
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£146.19
Penguin Putnam Inc Mutants
Book Synopsis
£17.00
Penguin Putnam Inc Life at the Speed of Light From the Double Helix
Book Synopsis“Venter instills awe for biology as it is, and as it might become in our hands.” —Publishers WeeklyOn May 20, 2010, headlines around the world announced one of the most extraordinary accomplishments in modern science: the creation of the world’s first synthetic lifeform. In Life at the Speed of Light, scientist J. Craig Venter, best known for sequencing the human genome, shares the dramatic account of how he led a team of researchers in this pioneering effort in synthetic genomics—and how that work will have a profound impact on our existence in the years to come. This is a fascinating and authoritative study that provides readers an opportunity to ponder afresh the age-old question “What is life?” at the dawn of a new era of biological engineering.
£14.45
The University of Chicago Press The Genealogical Science
Book SynopsisAnalyzes the scientific work and social implications of the flourishing field of genetic history. This book examines genetic history's working assumptions about culture and nature, identity and biology, and the individual and the collective.Trade Review"The Genealogical Science is an important book, deeply informed about contemporary genetics and the cultures of genealogical analysis that have emerged from the wealth of scientific work. Nadia Abu El-Haj offers the most sustained analysis to date of both the scientific and socio-cultural grounds of genetic and genealogical science. In doing so, she significantly advances recent claims in anthropology and science studies about the entanglements of nature and culture, science and politics." -David Theo Goldberg, University of California, Irvine"
£999.99
University of Chicago Press Truth Machine The Contentious History of DNA
Book SynopsisDNA profiling is often heralded as unassailable criminal evidence, a veritable "truth machine" that can overturn convictions based on eyewitness testimony, confessions, and other forms of forensic evidence. This book traces the controversial history of DNA fingerprinting by looking at court cases in the US and UK from the mid-1980s onwards.Trade Review"I could not put it down. This is a must-read for anyone interested in the history of science." (Times Higher Education) "An interesting read.... It illustrates that the controversy of DNA profiling is rooted not in the science, but mainly in the restrictions of the adversarial system." (Nature)"
£999.99
Back Bay Books The Violinists Thumb
Book Synopsis
£19.79
Random House USA Inc The Origin of Species Modern Library By Means of
Book SynopsisIntroduction by Edward J. Larson Perhaps the most readable and accessible of the great works of scientific inquiry, The Origin of Species sold out its first printing on the very day it was published in 1859. Theologians quickly labeled Charles Darwin the most dangerous man in England and, as the Saturday Review noted, the uproar over the book quickly “passed beyond the bounds of the study and lecture-room into the drawing-room and the public street.” Based largely on Darwin’s experience as a naturalist while on a five-year voyage aboard H. M. S. Beagle, The Origin of Species set forth a theory of evolution and natural selection that challenged contemporary beliefs about divine providence and the immutability of species. This Modern Library edition includes a Foreword by the Pulitzer Prize–winning science historian Edward J. Larson, an introductory historical sketch, and a glossary Darwin later added to th
£13.50
Alfred A. Knopf DNA The Story of the Genetic Revolution
Book SynopsisThe definitive insider's history of the genetic revolution--significantly updated to reflect the discoveries of the last decade. James D. Watson, the Nobel laureate whose pioneering work helped unlock the mystery of DNA's structure, charts the greatest scientific journey of our time, from the discovery of the double helix to today's controversies to what the future may hold. Updated to include new findings in gene editing, epigenetics, agricultural chemistry, as well as two entirely new chapters on personal genomics and cancer research. This is the most comprehensive and authoritative exploration of DNA's impact--practical, social, and ethical--on our society and our world.
£26.96
WW Norton & Co The Seven Daughters of Eve The Science that
Book SynopsisThe national bestseller that reveals how we are descended from seven prehistoric women.Trade Review"A lovely, rollicking book, direct and clear.... [A] fascinating glimpse into anthropology in the era of the genome." -- Wall Street Journal"Sykes recounts his tale of discovery with the drama it warrants...gripping." -- New York Times Book Review"Scientifically accurate and understandable to the layperson.... [The Seven Daughters of Eve] will be recognized as an important work, bringing molecular anthropology to a mass audience." -- Nature"A natural storyteller, [Sykes] relates the history of developing genetics up to contemporary times as the DNA of genes is decoded.... A riveting account showing how archeological evidence and molecular biology findings complement one another in the challenge to unearth our past and our beginnings." -- Choice"Sykes has solved some of the hottest debates about human origins." -- Publishers Weekly
£13.29
WW Norton & Co Endless Forms Most Beautiful
Book Synopsis“A beautiful and very important book.”—Lewis Wolpert, American ScientistTrade Review"One of the essential books of our times…[explains] for a general audience how the shapes of organisms are produced by genes." -- Peter Forbes - The Guardian"[Carroll] reveals a remarkable series of insights into how evolution has shaped—and continues to shape—the wondrous assortment of creatures that share this planet with us. He emerges as the new, user-friendly public face of evolutionary science." -- Thomas Hayden - US News & World Report"Carroll is a gifted writer…In light of this new understanding (Evo Devo), the objections to evolutionary theory based on transitional gaps and irreducible complexity become more obtuse than ever." -- Library Journal"Combines clear writing with a deep knowledge." -- Publishers Weekly
£13.29
WW Norton & Co A Dominant Character
Book SynopsisOne of the Wall Street Journal's 10 Best Books of 2020 One of the New York Times's 100 Notable Books of 2020 A biography of J. B. S. Haldane, the brilliant and eccentric British scientist whose innovative predictions inspired Aldous Huxley’s Brave New World.Trade Review"Fascinating.... A Dominant Character is the best Haldane biography yet. With science so politicized in this country and abroad, the book could be an allegory for every scientist who wants to take a stand." -- Jonathan Weiner - New York Times Book Review"Samanth Subramanian is a crisp, elegant writer who has produced a compelling biography of this dazzling man. A Dominant Character is perfectly paced.... It can be read with the utmost pleasure by everyone who likes to admire a fine intellect in action and to see respect paid to outstanding intelligence." -- Richard Davenport-Hines - Wall Street Journal"Balanced and modern ... [A Dominant Character] should prove engaging to readers interested in the birth of genetics and in the intersection of science and political belief." -- P. William Hughes - Science"Astute and sympathetic." -- The Economist"Superb.... Subramanian does a masterly job of summarising a rich and rough life.... Haldane deserves a biographer who is eloquent, intelligent, fair, but unsparing and as good at explaining science as politics. Not an easy combination, but he has got one." -- Times [UK]"Excellent.... Full of insight and felicitous writing." -- David Brown - American Scholar"A wholly delightful, even brilliant, exploration of the scientific mind. Subramanian brings alive J. B. S. Haldane’s rollicking, unbelievable life journey from privileged English childhood to Indian asylum. He writes with grace and confidence about both the science and the man, a ‘Darwinian preacher’ whose life explains why scientists in our age of artificial intelligence and revolutionary genetics need to think politically. A Dominant Character is a captivating story of prickly genius, sexual scandal, and radical politics." -- Kai Bird, Pulitzer Prize–winning historian and director of the Leon Levy Center for Biography"The twentieth-century British geneticist J. B. S. Haldane remains one of the most influential scientists of modern times. And this remarkable biography by Samanth Subramanian, which brings to life Haldane at his brilliant, unpredictable, outspoken, visionary best, will make you see exactly why his light still shines so brightly today." -- Deborah Blum, Pulitzer Prize–winning author of The Poison Squad: One Chemist’s Single-Minded Crusade for Food Safety at the Turn of the Twentieth Century"A wonderful book about one of the most important, brilliant, and flawed scientists of the 20th century—that explains much not only about J. B. S. Haldane but about the complex times he lived in." -- Peter Frankopan, author of The Silk Roads"A marvelous, comprehensive, and entertaining biography of J. B. S. Haldane, who made major contributions to many fields. His biggest impact was on evolutionary biology, as a major founder of the theory of population genetics. Subramanian has done impressive research on Haldane’s background, scientific contributions, and political controversies—this will be the definitive work on his life from now on." -- Joe Felsenstein, professor emeritus of genome sciences and of biology, University of Washington
£28.79
WW Norton & Co Case Studies in Cancer
Book SynopsisA case-based approach to cancer biology.
£70.93
John Wiley & Sons Inc Introducing Proteomics
Book SynopsisIntroducing Proteomics gives a concise and coherent overview of every aspect of current proteomics technology, which is a rapidly developing field that is having a major impact within the life and medical sciences. This student-friendly book, based on a successful course developed by the author, provides its readers with sufficient theoretical background to be able to plan, prepare, and analyze a proteomics study. The text covers the following: Separation Technologies Analysis of Peptides/Proteins by Mass Spectrometry Strategies in Proteomics This contemporary text also includes numerous examples and explanations for why particular strategies are better than others for certain applications. In addition, Introducing Proteomics includes extensive references and a list of relevant proteomics information sources; essential for any student. This no-nonsense approach to the subject tells students exactly what they nTrade Review"He introduces undergraduate students to the general principles and methods of the field without delving very deeply into any of the details. Graduate students and researchers could also use the book to refresh their memory or catch up with recent developments." (Booknews, 1 June 2011)Table of ContentsPreface ix Acknowledgements xi 1 Introduction 1 1.1 What Are the Tasks in Proteomics? 1 1.2 Challenges in Proteomics 5 1.3 Proteomics in Relation to Other -omics and System Biology 10 1.4 Some General Applications of Proteomics 12 1.5 Structure of the Book 18 References 18 2 Separation and Detection Technologies 21 2.1 Introduction to Experimental Strategies in Proteomics 21 2.2 Gel-Based Separation 31 2.3 Visualization and Analysis of Proteins/Peptides in Gels 40 2.4 Gel-Free Separation Technologies 54 2.5 Visualization of Proteins/Peptides from Hyphenated Methods 74 2.6 Chips in Proteomic Applications 81 References 81 3 Analysis of Peptides/Proteins by Mass Spectrometry 83 3.1 Basic Principles of Mass Spectrometry for Proteomics 83 3.2 Ionization Methods for Small Amounts of Biomolecules 101 3.3 Mass Analyzers and Mass Spectrometers 116 3.4 Concluding Remarks on Mass Analyzers for Proteomics 170 References 170 4 Analysis and Interpretation of Mass Spectrometric and Proteomic Data 173 4.1 Introduction 173 4.2 Analysis of MS Data 174 4.3 Analysis of MS/MS Data 192 4.4 Quantification of LC MS and MS/MS Data from Complex Samples 209 4.5 Bioinformatic Approaches for Mass Spectrometric Proteome Data Analysis 213 References 218 5 Strategies in Proteomics 221 5.1 Imaging Mass Spectrometry 221 5.2 Qualitative Proteomics 223 5.3 Differential and Quantitative Proteomics 234 5.4 Analysis of Posttranslational Modifications 257 5.5 Interaction Proteomics 261 5.6 Proteomics as Part of Integrated Approaches 266 References 271 Index 275
£110.15
John Wiley and Sons Ltd Oomycete Genetics and Genomics
Book SynopsisThis book brings together the knowledge from and tools for genetic and genomic research into oomycetes to help solve the problems this pathogen poses to crops and animals. Armed with the information presented here, researchers can use oomycete data to solve practical problems and gain insight into future areas of interest. Key Features: Offers an up-to-date coverage of research into oomycetes which has advanced with biochemical and molecular analyses in recent years Helps researchers use oomycete data to solve practical problems, like damage to crop and animal resources Includes a section on interactions with animal hosts Offers perspective on future areas of research Assembles an international author base Trade Review"The whole is extremely well-produced, and I especially liked the tipped-in signature of colour plates on coated paper comprising colour versions of eight half-tone figures from various chapters. It also seems as well up-to-date as can be expected in such multiauthored works, with many papers from 2008 being cited. And the price is reasonable by current standards for a book of this quality. The editors are to be congratulated on marshalling such a work, which clearly merits wide circulation amongst the broader mycological community." (IMA Fungus, December 2010) Table of ContentsFOREWORD. PREFACE. CONTRIBUTORS. Chapter 1 The Evolutionary Phylogeny of Oomycetes—Insights Gained from Studies of Holocarpic Parasites of Algae and Invertebrates (Gordon W. Beakes and Satoshi Sekimoto). Chapter 2 Ecology of Lower Oomycetes (Martina Strittmatter, Claire M.M. Gachon, and Frithjof C. Kupper). Chapter 3 Taxonomy and Phylogeny of the Downy Mildews (Peronosporaceae) (Marco Thines, Hermann Voglmayr, and Markus Goker). Chapter 4 An Introduction to the White Blister Rusts (Albuginales) (Marco Thines and Hermann Voglmayr). Chapter 5 The Asexual Life Cycle (Adrienne R. Hardham). Chapter 6 Sexual Reproduction in Oomycetes: Biology, Diversity, and Contributions to Fitness (Howard S. Judelson). Chapter 7 Population Genetics and Population Diversity of Phytophthora infestans (William E. Fry, Niklaus J. Gru¨nwald, David E.L. Cooke, Adele McLeod, Gregory A. Forbes, and Keqiang Cao). Chapter 8 Phytophthora capsici: Sex, Selection, and the Wealth of Variation (Kurt Lamour). Chapter 9 Evolution and Genetics of the Invasive Sudden Oak Death Pathogen Phytophthora ramorum (Niklaus J. Grünwald and Erica M. Goss). Chapter 10 Phytophthora sojae: Diversity Among and Within Populations (Anne Dorrance and Niklaus J. Grunwald). Chapter 11 Pythium Genetics (Frank Martin). Chapter 12 Bremia lactucae and Lettuce Downy Mildew (Richard Michelmore, Oswaldo Ochoa, and Joan Wong). Chapter 13 Downy Mildew of Arabidopsis Caused by Hyaloperonospora arabidopsidis (Formerly Hyaloperonospora parasitica) (Nikolaus L. Schlaich and Alan Slusarenko). Chapter 14 Interactions Between Phytophthora infestans and Solanum (Mireille van Damme, Sebastian Schornack, Liliana M. Cano, Edgar Huitema, and Sophien Kamoun). Chapter 15 Phytophthora sojae and Soybean (Mark Gijzen and Dinah Qutob). Chapter 16 Phytophthora brassicae As a Pathogen of Arabidopsis (Felix Mauch, Samuel Torche, Klaus Schläppi, Lorelise Branciard, Khaoula Belhaj, Vincent Parisy, and Azeddine Si-Ammour). Chapter 17 Aphanomyces euteiches and Legumes (Elodie Gaulin, Arnaud Bottin, Christophe Jacquet, and Bernard Dumas). Chapter 18 Effectors (Brett M. Tyler). Chapter 19 Pythium insidiosum and Mammalian Hosts (Leonel Mendoza). Chapter 20 Saprolegnia—Fish Interactions (Emma J. Robertson, Victoria L. Anderson, Andrew J. Phillips, Chris J. Secombes, Javier Diéguez-Uribeondo, and Pieter van West). Chapter 21 Aphanomyces astaci and Crustaceans (Lage Cerenius, M. Gunnar Andersson, and Kenneth Söderhall). Chapter 22 Progress and Challenges in Oomycete Transformation (Howard S. Judelson and Audrey M.V. Ah-Fong). Chapter 23 In Planta Expression Systems (Vivianne G.A.A. Vleeshouwers and Hendrik Rietman). Chapter 24 Gene Expression Profiling (Paul R.J. Birch and Anna O. Avrova). Chapter 25 Mechanisms and Application of Gene Silencing in Oomycetes (Stephen C. Whisson, Anna O. Avrova, Laura J. Grenville Briggs, and Pieter van West). Chapter 26 Global Proteomics and Phytophthora (Alon Savidor). Chapter 27 Strategy and tactics for genome sequencing (Michael C. Zody and Chad Nusbaum). INDEX.
£172.85
John Wiley & Sons Inc Reverse Genetics of RNA Viruses
Book SynopsisReverse genetics, the genetic manipulation of RNA viruses to create a wild-type or modified virus, has led to important advances in our understanding of viral gene function and interaction with host cells. Since many severe viral human and animal pathogens are RNA viruses, including those responsible for polio, measles, rotaviral diarrhoea and influenza infections, it is also an extremely powerful technique with important potential application for the prevention and control of a range of human and animal viral diseases. Reverse Genetics of RNA Viruses provides a comprehensive account of the very latest developments in reverse genetics of RNA viruses through a wide range of applications within each of the core virus groups including; positive sense, negative sense and double stranded RNA viruses. Written by a team of international experts in the field, it provides a unique insight into how the field has developed, what problems are being addressed now and where applicatTable of ContentsList of contributors xi Acknowledgements xiii 1 Introduction 1 Anne Bridgen 1.1 Background 1 1.2 Reverse genetics for different classes of genome 2 1.3 Methodology 5 1.4 Difficulties in establishing a reverse genetics system 11 1.5 Recent developments 13 1.6 Are there any boundaries for conducting reverse genetics? 13 References 15 Part I Positive sense RNA viruses 25 2 Coronavirus reverse genetics 27 Maria Armesto, Kirsten Bentley, Erica Bickerton, Sarah Keep and Paul Britton 2.1 The Coronavirinae 27 2.2 Infectious bronchitis 28 2.3 Coronavirus genome organisation 29 2.4 The coronavirus replication cycle 30 2.5 Development of reverse genetics system for coronaviruses including IBV 33 2.6 Reverse genetics system for IBV 37 2.7 Reverse genetics systems for the modification of coronavirus genomes 40 2.8 Using coronavirus reverse genetics systems for gene delivery 49 Acknowledgements 51 References 51 3 Reverse genetic tools to study hepatitis C virus 64 Alexander Ploss 3.1 Introduction: hepatitis C 64 3.2 Hepatitis C virus 65 3.3 Construction of infectious clones for hepatitis C virus 68 3.4 Study of HCV RNA replication in cell culture systems 68 3.5 Use of HCV replicons to study viral replication 70 3.6 Utility of replicons for drug screening 71 3.7 Development of the infectious cell culture systems for HCV 71 3.8 Construction of intergenotypic viral chimeras 72 3.9 Non-JFH1 derived genomes 74 3.10 Cell lines that support HCV replication 74 3.11 Study of HCV in physiologically more relevant cell culture systems 75 3.12 Animal models for HCV infection 76 3.13 Reverse genetics of clinically relevant HCV genotypes in vivo 77 3.14 Conclusion 78 Acknowledgments 78 References 78 4 Calicivirus reverse genetics 91 Ian Goodfellow 4.1 Introduction 91 4.2 Feline calicivirus 93 4.3 Murine norovirus 97 4.4 Porcine enteric calicivirus 103 4.5 Rabbit haemorrhagic disease virus 104 4.6 Human norovirus 104 4.7 Conclusion 106 Acknowledgements 107 References 107 Part II Negative sense RNA viruses 113 5 Reverse genetics of rhabdoviruses 115 Alexander Ghanem and Karl-Klaus Conzelmann 5.1 Introduction: the Rhabdoviridae family 115 5.2 Rhabdovirus reverse genetics 121 5.3 Applications and examples 132 5.4 Conclusion 137 Acknowledgements 137 References 137 6 Modification of measles virus and application to pathogenesis studies 150 Linda J. Rennick and W. Paul Duprex 6.1 Introduction 150 6.2 Measles: the disease 150 6.3 Measles: the infectious agent 151 6.4 RNA synthesis: a tail of two processes 154 6.5 Transcription: starting, stopping, dropping off or starting again 154 6.6 From transcription to replication: the elusive switch 155 6.7 Getting in and getting out 157 6.8 Measles virus: reverse genetics 158 6.9 Future perspectives 181 Acknowledgements 182 References 182 7 Bunyavirus reverse genetics and applications to studying interactions with host cells 200 Richard M. Elliott 7.1 Introduction: the family Bunyaviridae 200 7.2 Bunyavirus replication 201 7.3 History of bunyavirus reverse genetics 203 7.4 Minigenome systems for bunyaviruses 205 7.5 Virus-like particle production 207 7.6 Rescue systems for bunyaviruses 208 7.7 Application of reverse genetics to study bunyavirus replication 208 7.8 Outlook 215 References 216 8 Using reverse genetics to improve influenza vaccines 224 Ruth A. Elderfield, Lorian C.S. Hartgroves and Wendy S. Barclay 8.1 Introduction 224 8.2 Influenza vaccines 227 8.3 The use of reverse genetics to generate recombinant influenza A, B and C viruses 229 8.4 Using reverse genetics technology for generation of pandemic virus vaccine 232 8.5 Other strategies for generating live attenuated vaccines based on viruses engineered by reverse genetics 235 8.6 Strategies to improve the safety or yield of influenza vaccines 238 8.7 Improvements to the PR8 high growth strain 239 8.8 Improving the immunogenicity by engineering recombinant viruses that express cytokine genes 240 8.9 Novel species-specific attenuation that takes advantage of microRNAs 240 8.10 Conclusion 241 References 241 Part III Double-stranded RNA viruses 251 9 Bluetongue virus reverse genetics 253 Mark Boyce 9.1 Introduction to Bluetongue virus 253 9.2 Bluetongue virus replication 254 9.3 Reverse genetics 260 9.4 Uses of reverse genetics in orbivirus research 271 9.5 Future perspectives 278 10 Genetic modification in mammalian orthoreoviruses 289 Sanne K. van den Hengel, Iris J.C. Dautzenberg, Diana J.M. van den Wollenberg, Peter A.E. Sillevis Smitt and Rob C. Hoeben 10.1 Introduction 289 10.2 Forward-genetics in orthoreoviruses 296 10.3 Reovirus/cell interactions 297 10.4 Reverse-genetics in orthoreoviruses 301 10.5 Reovirus as an oncolytic agent 306 10.6 Conclusion 308 References 309 Part IV Recent and future developments 319 11 Reverse genetics and quasispecies 321 Antonio V. Border´ýa and Marco Vignuzzi 11.1 Definition of quasispecies and evidence 321 11.2 Reverse genetics and RNA virus population heterogeneity: consensus is always a compromise 328 11.3 Examples of the use of the theory to disable or manipulate the quasispecies under controlled environments 333 11.4 Future prospects of virus population genetics and reverse genetics 339 11.5 Conclusion 341 References 342 12 Summary and perspectives 350 Anne Bridgen 12.1 Introduction 350 12.2 Analysis of the role of specific non-coding sequence motifs involved in replication, transcription, polyadenylation and packaging 351 12.3 Analysis of the roles of viral proteins 352 12.4 Analysis of virus–host interactions at a global level 353 12.5 Understanding the basis of pathogenicity 354 12.6 Real-time virus imaging in vitro and in vivo 355 12.7 Structure-function analysis of viruses and viral domains 356 12.8 Vaccine generation 357 12.9 Drug development 359 12.10 Gene delivery and knock-out in plant cells including virus-induced gene silencing (VIGS) 361 12.11 Gene delivery in arthropod and mammalian cells 362 12.12 Development of oncolytic virus and adaptation to this purpose 363 12.13 Personal highlights and future directions 364 References 366 Index 375
£117.95
John Wiley & Sons Inc Nucleases Molecular Biology and Applications
Book SynopsisProvides detailed applications of nucleases in recombinant DNA technology, molecular cloning, biotechnology, pharmaceuticals, and commerce. This work covers the role of nucleases in biological systems, with focus on understanding their role in causing human diseases.Trade Review"...a useful text for students and professionals..." (Genomics and Proteomics, May 1, 2003)Table of ContentsPreface. List of Nobel Prize Winners for Their Research Work with Nucleases. About the Author. 1. Introduction. I. Historical Perspectives. II. Protein, RNA, DNA, and Other Molecules as Nucleases. III. Nature of Enzymatic Reactions Catalyzed by Nucleases. IV. Classification. A. Nature of Substrates. B. Mode of Attack. C. Site-Specificity and Structure-Selectivity. V. Methods for the Study of Nucleases. A. Methods for the Assay of the Enzymatic Activity. B. Methods for the Study and Characterization of Nucleases. VI. Genetics of Nucleases and Biological Roles. VII. Applications of Nucleases. 2. Ribonuclease. I. General Ribonucleases. A. Microbial Ribonucleases. 1. RNaseT1. 2. RNaseT2. B. Mammalian Ribonucleases. 1. Bovine Pancreatic Rnase. 2. RNaseA. 3. Human Pancreatic Ribonuclease (HPR). 4. Human Nonsecretory Ribonuclease (HNSR). 5. Human Major Basic Protein (MBP), Eosinophil Cationic Protein (ECP) and Eosinophil-Derived Neurotoxin (EDN). 6. Angiogenin. 7. Interferon-Induced Mammalian Ribonuclease. 8. Human RNase with a Possible Role in Tumor Suppression. C. Plant Ribonucleases. D. Evolution of Ribonucleases. II. Ribonucleases Involved in RNA Processing (Trimming, Splicing, and Editing). A. RNaseIII and RNaseIII-Like Enzymes. B. RNaseP. C. RNaseE. D. RNaseM5. E. RNaseD. F. Eukaryotic RNA-Splicing Enzymes. 1. Yeast tRNA Splicing Endonuclease. III. Ribonuclease H. A. E. coli RNaseH. B. Retroviral Reverse Transcriptase RNaseH. C. Yeast RNaseH. D. Human RNaseH. E. Other Eukaryotic RNaseH. F. Biological Function of RNaseH. IV. Proofreading Activity of RNA Polymerase. 3. Deoxyribonuclease. I. Classification of Enzymes. A. Deoxyribonucleases. B. Endonucleases C. Exonuclease. II. Properties of Enzymes from Different Organisms. A. Bacterial Enzymes. 1. Exonuclease I. 2. Exonuclease II. 3. Exonuclease III. 4. Application of the Enzyme Exonuclease III. 5. Exonucleases IVA and IVB. 6. Exonuclease V (RecBCD Enzyme). 7. RecBCD (Exo V) from Other Organisms. 8. Exonuclease VI. 9. Exonuclease VII. 10. Exonucleases Associated with DNA Polymerases. 11. Exonuclease VIII. B. Endonucleases. 1. Bacterial Enzymes. 2. Mammalian Deoxyribonuclease. 4. Restriction Endonucleases. I. Occurrence, Classification, and Their General Properties. A. Different Restriction Endonucleases and Their Properties. II. Type I Restriction Endonucleases. A. Purification and General Properties. B. Recognition Sequences and Nature of Substrate. C. Different Kinds of Type II Restriction Endonucleases. D. Genetics. E. Cleavage Mechanism. III. Type II Restriction Endonucleases. A. Enzyme Purification and Assay. B. General Properties of the Enzyme. C. Crystal Structure of the Restriction Endonucleases. D. Reaction Conditions and Enzyme Specificity. E. Nature of Substrate. 1. Synthetic Oligonucleotides. 2. DNA with Base Analogs. 3. Methylated DNA. 4. Single-Stranded DNA. 5. DNA-RNA Hybrids as Substrate. F. Inhibition of Restriction Endonucleases. G. Restriction Endonuclease Genes. IV. Type III Restriction Endonucleases. V. Evolutionary Significance and Biological Role. VI. Application of Restriction Nucleases. VII. General Tips for Beginners or the First-Time Users of Restriction Enzymes. 5. Damage-Specific Nucleases. I. Classification and Assay . A. AP Endonucleases. B. Enzymes that Directly Attack Phosphodiester Linkages in the Damaged DNA Region. C. Assay. II. Properties of Two Groups of Enzymes from Different Organisms. A. AP Endonucleases. 1. AP Endonucleases Associated with DNA Glycosylase Activity. 2. M. luteus Enzyme. 3. E. coli Endonuclease III. B. AP Endonuclease Associated with Other Enzyme Activities. 1. E. coli Exonuclease III AP-Endonuclease Activity. C. AP Endonucleases. 1. E. coli AP Endonucleases. 2. Fungal Apurinic Endonuclease. 3. Drosophila AP Endonucleases. 4. Human AP Endonucleases. 5. Plant AP Endonuclease. D. Direct-Acting Enzymes. 1. E. coli UV Endonuclease. 2. Human Excision Nuclease. 6. Topoisomerases. I. Choreography and Topology of DNA. II. Enzyme Assay. A. Electron Microscopy. B. Sedimentation Methods. C. Agarose Gel Electrophoresis. III. Properties of Enzymes from Different Groups of Organisms. A. Prokaryotic Topoisomerases. 1. Prokaryotic Topoisomerase I. 2. Prokaryotic Topoisomerase II. 3. Properties of Gyrase. 4. Other Activities of Gyrase. 5. Prokaryotic Topoisomerase III. B. Eukaryotic Topoisomerases. 1. Eukaryotic Topoisomerase I. 2. Eukaryotic Topoisomerase II. C. Mitochondrial Topoisomerase. D. Viral Topoisomerases. IV. Genetics and Biological Role. A. Prokaryotic Topoisomerase Mutants. 1. Topoisomerase I. 2. Topoisomerase II. B. Eukaryotic Topoisomerase Mutants. 1. Topoisomerase I Mutants of Yeast. 2. Topoisomerase II Mutants of Yeast. 3. Topoisomerase Mutants of Higher Eukaryotes. 7. Recombinases. I. General Description and Classification. A. General Recombinase. B. Site-Specific Recombinase. 1. Prokaryotic. 2. Eukaryotic. C. Transpositional Recombinase. D. RNA Recombinase. II. Properties of Different Recombinases. A. General Recombinase. 1. Initiase. 2. X-Solvase. 3. Correctase. B. Site-Specific Recombinase. C. Prokaryotic Site-Specific Recombinase. 1. Integrase. 2. Invertase. 3. Resolvase. D. Eukaryotic Site-Specific Recombinase. 1. Eukaryotic Site-Specific Recombinase. 2. ''Homing'' Nuclease (Intron Coded Nuclease). 3. Viral Integrase. E. Transpositional Recombinase. 1. Prokaryotic Transposases. 2. Eukaryotic Transposase. 3. Retrotransposable Elements and Retrotransposases. F. Control of Recombinases. G. RNA Recombinase. 8. Sugar-NonSpecific Nucleases. I. General Description, Classification, and Methods of Assay. II. Properties of Enzymes from Different Groups of Organisms. A. Microbial Nucleases. 1. Neurospora crassa Endonuclease. 2. S1 Nuclease. 3. Yeast Nucleases. 4. Micrococcal Nuclease. 5. Bal-31 Nucleases. B. Animal Nucleases. 1. Spleen Exonucleases. 2. Snake Venom Exonuclease. C. Plant Nucleases. 1. Mung Bean Endonuclease. 2. Other Plant Nucleases. D. Parasitic Protozoan Nuclease. 9. Nonprotein Nucleases. I. Ribozymes. A. RNaseP. 1. Protein Component of RNaseP. B. Introns as Ribozymes. 1. Group I Intron Ribozymes. 2. Mechanism of Catalysis by Group I Intron Ribozyme. 3. Assay of Ribozyme Activity of Intron RNA or Other RNA. C. Group II Intron Ribozymes. D. Splicosomal snRNA Ribozyme. 1. Proteins that Facilitate the Ribozyme Activity of RNA Nucleases. E. Maturase. F. Hammerhead RNA as Ribozyme. G. Cis- and Trans-Acting Ribozyme Endonuclease. II. DNAzymes. III. Chemzymes. A. Chemicals and Metal Ligand Complexes as Nucleases. 1. Piperidine. 2. Hydrogen Peroxide. 3. DNA Intercalating Agents. 4. Phenanthroline. 5. Factors Controlling the DNA Cleavage by Chemzymes. B. Peptides. IV. Designer Nuclease. 10. Molecules that Interact with Nucleases. I. Inhibitors. A. Proteins as Nuclease Inhibitors. 1. DNase Inhibitor-Protein. 2. RNase Inhibitor-Protein. B. RNA as Nuclease Inhibitors. C. Other Molecules that Act as Nuclease Inhibitors. II. Proteins that Interfere with the Activity of Nuclease by Interacting with the Substrate (Nucleic Acids). III. DNA Sequences that Interact with Nucleases. A. Chi-Like Elements in Eukaryotes. IV. Other Inhibitor Molecules. V. Proteins that Interact with DNA or Nuclease to Orchestrate the Activity of Nucleases. 11. Biological Function of Nucleases. I. Replication. A. Three Steps in DNA Replication. 1. Initiation. 2. Elongation. 3. Termination. B. Role of Viral Nuclease in the Degradation of Host DNA. C. Involvement of Nuclease During the Separation of Daughter Helices at the End of Replication. D. Involvement of Nucleases in the Rolling Circle Mechanism of DNA Replication. E. Involvement of Nuclease in the Replication of Linear DNA. F. Involvement of Nuclease in the Replication of Chromosome in Eukaryotes. II. DNA Repair. A. Baseless Sites. B. Sites with Altered Base or Incorrect Base. C. Cross-Linking and Other Damages. D. DNA Repair Mechanisms. E. Excision Repair. F. Bypass Repair Pathways. G. Recombinational Repair Pathway. H. Inducible and Error-Prone Repair Pathway. I. Mismatch Repair. J. Mismatch Repair in Mammalian Cells. K. Incision of Damaged DNA is a Complex Process Involving Several Proteins. L. Excision Repair Mutants of Neurospora. M. Excision Repair Mutants of Yeast. N. Excision Repair Mutants of Drosophila. O. Excision Repair Mutants of Mammalian Cells. III. Recombination. A. Different Kinds of Genetic Recombination. B. Recombination Mechanisms and Nucleases. C. Gene Conversion and Postmeiotic Segregation. D. In Vitro Recombination System. E. Fungal Recombination Nucleases. F. Mismatch Repairs During Recombination. G. Recombination Pathways. 1. RecBCD Pathway. 2. RecFJ Pathway. 3. RecE Pathway. 4. Red Pathway. H. Recombinational Control of Gene Expression. I. Role of Recombinase in Mammalian Antibody Diversity, Allelic Exclusion, and Class Switch. J. T-Cell Surface Receptor. K. Application of Recombinases: Engineered Expression of Genes. IV. DNA Transfection or Transformation. V. Mutation. VI. DNA Supercoiling and Maintenance of Chromosome Structure. VII. Transcription. VIII. RNA Processing. A. RNA Trimming. B. RNA Splicing. C. RNA Editing. IX. Control of Translation. X. Viral Maturation and Encapsidation. XI. Nuclease in Defense Mechanism. XII. Apoptosis and Nucleic Acid Salvage. 12. Nucleases and Human Diseases: Basis for Application. I. Involvement of Nucleases in Human Disease. A. Xeroderma Pigmentosum. B. Ataxia Telangiectasia. C. Cockayne Syndrome. D. Cancer. E. Aging-Werner Syndrome. F. Immunological Diseases. G. Nucleases and Neurological Disorders. H. Human Diseases Involving Defective Protein Folding. I. Other Human Diseases. II. Reverse Genetics, Human Diseases, and Nucleases. III. Use of Nucleases in Control of Human Disease. 13. Nucleases as Tools. I. Nature of ''Transforming Principle'' as DNA. II. Isolation of DNA and RNA. III. Nearest-Neighborhood Analysis. IV. Isolation of a Gene. V. Uniparental Transmission During Cytoplasmic Inheritance. VI. Physical Mapping of DNA. VII. Use of Nuclease in the Development of Recombinant DNA Technology and the Molecular Cloning of a Gene. VIII. Construction of an Artificial Chromosome. IX. New Method for Mapping Eukaryotic Chromosomes. A. Chromosome Walking (Overlap Hybridization). B. Role of Nucleases in Transposon Mobility. X. Use of Nuclease in the Physical Mapping of a Mutational Site. XI. Biological Activity of a DNA Segment. A. Use of Nucleases in the Identification of the Function of a DNA Segment via Transformation Experiments. B. Use of Nucleases in the Deletion Mapping of Biological Activity. C. Use of Nuclease in Identification of the Function of DNA Segment via Marker Rescue Method. XII. Organization of Eukaryotic Chromosomes. XIII. Distinction Between Active and Inactive Genes: The Relation Between Activity of a Gene and a Nuclease-Sensitive Site. XIV. DNase Footprinting. XV. Construction of Mutants: Site-Specific Mutation and Protein Engineering. XVI. Nucleases in Directed Mutagenesis. XVII. Nick Translation and Labeling of DNA with High-Specificity Radioactivity. XVIII. Role of Nucleases in PCR. A. Proofreading by Nuclease During PCR Amplification. B. Application of 50 Nuclease in PCR Assay for Rapid Detection of a Known Gene in a DNA Sample(s). C. Application of Nucleases in SNP-Genotyping and Pharmacogenetics. XIX. Gene Knockout. XX. RNase Protection Assay. XXI. Use of Nucleases in Forensic Science. XXII. Human and Other Genome Projects. 14. Application of Nucleases in Biotechnology, Medicine, Industry, and Environments. I. Construction of Recombinant DNA and Molecular Cloning of Genes. II. Biotechnology of Microorganisms, Plants, Animals and Marine Organisms Based on Recombinant DNA Technology. III. Application in Medicine. A. Role of Nucleases in Predictive, Preventive, and Curative Medicine. B. Drug Designs. C. Antisense Strategy. IV. Nuclease Therapeutics and Therapeutic Targets. A. DNaseI and DNAzyme-Based Therapeutics. B. RNaseA and Ribozyme-Based Therapeutics. C. Gene Therapy and Enhancement Therapy. D. Gene Silencing. E. RNaseL and Interferon-Mediated Control of Viral Infection and treatment of Cancer. F. Recombinase-Mediated Control of Gene Expression. G. Poisoning of Topoisomerase-DNA Intermediates. V. Application in Forensics. VI. Application in Industry: Production of Flavor Enhancer of Food and Beverage. VII. Application in Environmental Problems. A. Bioremediation. B. Detection of Microbial Pathogens to Prevent Bioterrorism by 5' Nuclease in PCR Assay. 15. Nucleases and Evolution. I. Ribozyme as Evidence for the Early World of RNA. II. Chemzyme, Ribozyme, and Proteinzyme. III. The Role of Recombinase in Evolution. A. Present-Day Selfish DNA-Possible Origin From Transposon. IV. Nucleases and Control of DNA Transactions and Their Roles in Evolution. V. Role of Nucleases in Directed Mutagenesis: Adaptive Mutation an SOS Response. VI. Nucleases as Multifunctional Molecules. VII. DNA Sequence Analysis, Crystal Structure, and Bioinformatics. VIII. Possible Horizontal Transmission of Nuclease Gene and Intron. IX. Conclusions and Our Future in the World of Nucleases. References. Index.
£148.15
John Wiley & Sons Inc Understanding Genetics A Molecular Approach
a huge range and FREE tracked UK delivery on ALL orders.
£104.45
LUP - University of Michigan Press Disability in TwentiethCentury German Culture
Book SynopsisAn exploration of disability in Germany, from the Weimar Republic to the fall of the Berlin Wall. This book examines a range of literary and visual depictions of disability, focusing particular attention on disability and Nazi culture. It reveals how central the notion of disability is to modern German cultural history.Trade ReviewAn important and path-breaking book...immensely interesting, it will appeal not only to students of twentieth-century Germany but to all those interested in the growing field of disability studies. - Robert C. Holub, University of Tennessee ""A major, long-awaited book. The chapter on Nazi images is brilliant - certainly the best that has been written in this arena by any scholar."" - Sander L. Gilman, Emory University
£999.99
Johns Hopkins University Press Cracking the Genome Inside the Race to Unlock
Book SynopsisCracking the Genome is the definitive, balanced account of how the code that holds the answer to the origin of life, the evolution of humanity, and the future of medicine was finally broken.Trade Review"For an up-to-the-minute account of one of the most dramatic periods in present-day science, Cracking the Genome is an essential read. Sunday Times A superb job... A tantalizing glimpse of the ethical perils and technological possibilities awaiting humanity. Los Angeles Times A rollicking good tale about an enduring intellectual monument. American Scientist The race is over, and Davies was there, all along, providing the running commentary-and there, too, at the finish line. In Cracking the Genome, he hands out the prizes. The Independent Davies has tracked one of the most important stories ever to unfold. Davies helps readers understand how the deciphering of our genetic code will revolutionize our lives while posing serious ethical dilemmas. Science News An impressive job of contextualizing the science within a political, economic, and social framework, creating a lively tale as accessible to non-specialists as it is to scientists. Publishers Weekly Investors and others looking for a quick primer on the science and business of biotechnology will find this a useful guide. Business Week In Davies' prose, this story of molecular biology and the Human Genome Project is as compelling as any Arthurian legend. In a fast-moving approachable style, Davies captures the uncovering of biology's Holy Grail, relying on his own expertise in genetics and interviews with key players such as Collins and Venter. -- Margaret R. McLean History and Philosophy of the Life Sciences 2004Table of ContentsPreface to The Johns Hopkins EditionIntroduction Chapter 1. Knights of the Double Helix: The Quest for Biology's Holy GrailChapter 2. Reading the Book of Life: A Quick Voyage around the Human GenomeChapter 3. The Eye of the TIGR: J. Craig Venter—Maverick SequencerChapter 4. Loading the Bases: Francis Collins and the DNA DetectivesChapter 5. The Circle of Life: Decoding the First Free-Living CreaturesChapter 6. Treasures of the Lost Worlds: The Keys to Human Disease from Tristan da Cunha to IcelandChapter 7. Prize Fight: The Creation of Celera GenomicsChapter 8. The Story of Us: The Secrets of Who We AreChapter 9. The Croesus Code: Passion, Personality, and ProfitChapter 10. The Eighth Day: Braving the New World of Designer GenesChapter 11. The Language of God: A Defining Moment in the History of the Human RaceChapter 12. Genomania!NotesAcknowledgments Index
£30.90
