Genetic engineering Books
CABI Publishing Linear Models for the Prediction of the Genetic
Book SynopsisFundamental to any livestock improvement programme by animal scientists, is the prediction of genetic merit in the offspring generation for desirable production traits such as increased growth rate, or superior meat, milk and wool production. Covering the foundational principles on the application of linear models for the prediction of genetic merit in livestock, this new edition is fully updated to incorporate recent advances in genomic prediction approaches, genomic models for multi-breed and crossbred performance, dominance and epistasis. It provides models for the analysis of main production traits as well as functional traits and includes numerous worked examples. For the first time, R codes for key examples in the textbook are provided online. The book covers: - The relationship between the genome and the phenotype. - BLUP models for various livestock data and structure. - Incorporation of related ancestral parents and metafounders in prediction models. - Models for survival analysis and social interaction. - Advancements in genomic prediction approaches and selection. - Genomic models for multi-breed and crossbred performance. - Models for non-additive genetic effects including dominance and epistasis. - Estimation of genetic parameters including Gibbs sampling approaches. - Computation methods for solving linear mixed model equations. Suitable for graduate and postgraduate students, researchers and lecturers of animal breeding, genetics and genomics, this established textbook provides a thorough grounding in both the basics and in new developments of linear models and animal genetics.Table of Contents1: The Genome and phenotypes 2: Genetic evaluation with different sources of records 3: Genetic covariance between relatives 4: Best linear unbiased prediction of breeding value: univariate models with one random effect 5: Best linear unbiased prediction of breeding value: Models with random environmental effects 6: Best Linear unbiased prediction of breeding value: Multivariate models 7: Methods to reduce the dimension of multivariate models 8: Maternal traits models: Animal and reduced animal Models 9: Social interaction models 10: Analysis of longitudinal data 11: Genomic prediction and selection 12: Single-step approaches to genomics 13: Non-additive animal models 14: Genetic and genomic models for multibreed and crossbred analyses 15: Analysis of ordered categorical traits 16: Survival analysis 17: Estimation of genetic parameters 18: Use of Gibbs sampling in variance component estimation and breeding value prediction 19: Solving linear equations
£61.75
Burleigh Dodds Science Publishing Limited Instant Insights: Genetic Modification of Crops
Book SynopsisThis specially curated collection features six reviews of current and key research on genetic modification of crops.The first chapter reviews key challenges facing banana production, primarily the risk of species decimation by diseases such as Fusarium wilt, and considers how genetic modification may be a solution to this.The second chapter discusses the development and establishment of ‘Golden Rice’ - a biofortified variety designed as a health intervention to help alleviate the problem of vitamin A deficiency.The third chapter details recent advances in the genetic modification of important agronomic traits of soybean crops, such as herbicide tolerance and insect resistance. The fourth chapter addresses progress in and prospects for transgenic interventions in the improvement of grain legumes, concentrating on chickpea, pigeonpea, cowpea and more.The fifth chapter reviews recent research efforts in the production of genetically modified (GM) oil palm plants and looks towards establishing stable lines of commercially viable GM varieties.The final chapter describes recent progress relating to transgenic modification of cassava and how future research can strengthen food security and commercialization of the crop.Table of ContentsChapter 1 - Genetic modification of bananas: the long road to farmers’ fields: James Dale, Queensland University of Technology, Australia; Wilberforce Tushemereirwe, National Agricultural Research Organisation, Uganda; and Robert Harding, Queensland University of Technology, Australia; 1 Introduction 2 Banana improvement by genetic modification and gene editing 3 Case study: biofortified East African Highland bananas 4 Future trends and conclusion 5 References Chapter 2 - Biofortified Golden Rice: an additional intervention for vitamin A deficiency: Adrian Dubock, Golden Rice Humanitarian Board, Switzerland; 1 Introduction 2 The problem of vitamin A deficiency (VAD) 3 The origins of Golden Rice 4 Developing Golden Rice as a product 5 Current challenges to establishing Golden Rice as an additional VAD intervention 6 Conclusions 7 Acknowledgements 8 Where to look for further information References Chapter 3 - Advances in the genetic modification of soybeans: Wensheng Hou, Chinese Academy of Agricultural Sciences, China; 1 Introduction 2 Genetic modification of agronomic traits: herbicide tolerance and insect resistance 3 Genetic modification of other agronomic traits 4 Genome editing technology 5 Case studies 6 Summary 7 Future trends in research 8 Where to look for further information 9 References Chapter 4 - Genetic modification of grain legumes: Pooja Bhatnagar-Mathur and Kiran Kumar Sharma, International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), India; 1 Introduction 2 Genetic engineering of grain legumes 3 Genetic engineering of chickpea 4 Genetic engineering of pigeonpea 5 Genetic engineering of cowpea 6 Genetic engineering of lentil 7 Genetic engineering of pea (Pisum sativum) 8 Genetic engineering of peanut 9 Genetic engineering of other grain legumes: tepary bean, Vigna species and faba bean 10 Challenges in the commercialization of genetically engineered grain legumes 11 Conclusion 12 Future trends 13 Where to look for further information 14 References Chapter 5 - Advances in the genetic modification of oil palm: Denis J. Murphy, Head of Genomics and Computational Biology Research Group, University of South Wales, United Kingdom; 1 Introduction 2 Early and current genetically modified (GM) crop varieties 3 GM oil palm in Malaysia 4 Improving the fatty acid composition of palm oil 5 Progress to date in oil palm transformation 6 New technologies for genome editing – an alternative to ‘classical GM’ 7 Conclusions and future prospects 8 Where to look for further information 9 References Chapter 6 - Advances in genetic modification of cassava: P. Zhang, Q. Ma, M. Naconsie, X. Wu, W. Zhou, National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, China and J. Yang, Shanghai Chenshan Plant Science Research Center, Shanghai Chenshan Botanical Garden, China; 1 Introduction 2 Transition from model cultivars to farmer-preferred cultivars 3 Tools of gene expression regulation 4 Production of virus-resistant cassava 5 Cassava biofortifi cation for better nutrition 6 Starch modifi cation of cassava for industrial applications 7 Improving storage, root production and post-harvest storage 8 Future trends and conclusion 9 Where to look for further information 10 Acknowledgements 11 References
£44.51
Taylor & Francis Ltd Unnatural Selection: The Challenges of
Book SynopsisWith ever-advancing scientific understanding and technological capabilities, humanity stands on the brink of the potential next stage of evolution: evolution engineered by us. Nanotechnology, biotechnology, information technology and cognitive science offer the possibility to enhance human performance, lengthen life-span and reshape our inherited physical, cognitive and emotional identities. But with this promise come huge risks, complex choices and fundamental ethical questions: about evolution; about what it is to be human; and about control over, and the distribution of benefits from, new technology. Written by a range of experts in science, technology, bioethics and social science, Unnatural Selection examines the range of technological innovations offering lives that purport to be longer, stronger, smarter and happier, and asks whether their introduction is likely to lead to more fulfilled individuals and a fairer world. The breadth of approaches and perspectives make important reading for anyone who cares about the implications of humanity engineering its own evolution.Trade Review'Big changes are coming in every aspect of our lives. Should and will we embrace or reject them? (This) well-chosen collection of short but eye-opening essays will help you decide which choice is made.' Gregory M. Fahy PhD, cryobiologist, biogerontologist and former Director of the American Aging Association 'The whole idea of human enhancement divides people. The cautious emphasize the dangers of the techniques themselves, and the social and political consequences of allowing individual choice and commercial interests to prevail. Enthusiasts point out that humans have always striven to enhance human capabilities and extend lifespan. Isn't it unethical not to seek to improve on nature? This book deepens the debate, with perspectives from diverse disciplines and cultures explaining what the technologies are, what they might achieve and the societal consequences on a global scale.' Dr Mairi Levitt, Department of Philosophy, Lancaster UniversityTable of ContentsIntroduction * One World or Several? * The Nature of Human Natures * Longer? * Stronger? * Smarter? * Happier? * Fairer? * Governable? * Postscript: Choosing our Biological Future * Index
£43.42
CABI Publishing Environmental Risk Assessment of Genetically
Book SynopsisThe decline of many individual and wild fish stocks has commanded an increase in aquaculture production to meet the protein demands of a growing population. Alongside selective breeding schemes and expanding facilities, transgenic methods have received increasing attention as a potential factor in meeting these demands. With a focus on developing countries, this third text in the series provides detailed information on environmental biosafety policy and regulation and presents methodologies for assessing ecological risks associated with transgenic fish.Table of Contents1: Introduction to environmental risk assessment for transgenic fish 2: Problem formulation and options assessment: science-guided deliberation in risk assessment of transgenic fish 3: Development of transgenic fish: scientific background 4: Gene construct and expression: information relevant for risk assessment and management 5: Approaches to assessing gene flow 6: Assessing ecological effects of transgenic fish prior to entry into nature 7: Introduction to the concepts and methods of uncertainty analysis 8: Risk management: Reducing risk through confinement of transgenic fish 9: Risk management: Post-approval monitoring and remediation 10: Summary and synthesis
£103.82
CABI Publishing Environmental Risk Assessment of Genetically
Book SynopsisWithin Vietnam, the environmental risks of transgenic plants, managing transgenic products safely, and building modern labs to assess their safety has received increased investment and research. This book is the first scientific effort to synthesize information relevant to GM crops in Vietnam, taking Bt cotton as an example. It can be used as a technical manual to enable Vietnamese scientists to evaluate the potential environmental impacts of Bt cotton varieties prior to commercialization, and provides guidance for environmental risk assessment of any transgenic crop.Table of Contents1: Background on Cotton in Vietnam 2: Problem Formulation and Options Assessment PFOA 3: Transgene Expression and Locus Structure 4: Introduction to Non-target Asseessments 5: Non-target Herbivores 6: Predators 7: Parasitoids 8: Pollinators 9: Soil Processes 10: Soil Macroorganisms 11: Summary of Biodiversity and Non-target Assessment 12: Gene Flow and Consequences 13: Resistance Risk and Management
£199.00
CABI Publishing Environmental Impact of Genetically Modified
Book SynopsisThe genetic modification of crops continues to be the subject of intense debate, and opinions are often strongly polarised. Environmental Impact of Genetically Modified Crops addresses the major concerns of scientists, policy makers, environmental lobby groups and the general public regarding this controversial issue, from an editorially neutral standpoint. While the main focus is on environmental impact, food safety issues, for both humans and animals are also considered. The book concludes with a discussion on the future of agricultural biotechnology in the context of sustainability, natural resource management and future global population and food supply.Table of ContentsChapter 1: Agriculture, Ecosystem, and Environment. N Ferry and A MR Gatehouse Chapter 2: Transgenic Technology. P Christou Chapter 3: Novel Crops and Biofuels. Chapter 4: Environmental Risk Assessment F Tencalla Chapter 5: Insect Resistant GM Crops; Pest Resistance. B Tabashnik Chapter 6: Integrated Resistance Management, how can we prevent pest resistance in the future? D Wright and N Crickmore Chapter 7: Herbicide Tolerant GM Crops; Resistance and Management M Owen Chapter 8: Impact of GM Crops on non-target organisms J Romeis Chapter 9: Impact of GM Crops on Pollinators L. Malone and E P J Burgess Chapter 10: Impact of GM crops on soil and water ecology R Wheatley Chapter 11: Biodiversity. K Ammann Chapter 12: Potential Wider Impact: Farmland Birds. M Whittingham Chapter 13: Environmental Benefits of GM Crops M Edwards and G M Poppy Chapter 14: Safety for Human Consumption R Phipps Chapter 15: Post Commercialization testing and monitoring B Ohen Chapter 17: Monitoring Bt Resistance in the field, China as a case study K He Chapter 18: GM crops in Least Economically Developed Countries (LEDC) (Africa as a case study) D George, S Mugo and H De Groote Chapter 19: Developing a 21st century view of Agriculture and the Environment D Pimentel Chapter 20: Conclusions N Ferry and A Gatehouse
£119.56
CABI Publishing Insect-resistant Maize
Book SynopsisMany farmers in sub-Saharan Africa suffer heavily from crop losses due to stem borer pests. Insecticides are often unaffordable; therefore, maize plants must be made resistant to pests. The 'Insect Resistant Maize for Africa' (IRMA) project in Kenya was aimed at developing new maize varieties both by conventional methods and by biotechnologically incorporating the ?-endotoxin produced by the soil bacterium Bacillus thuringiensis. The author gives an impartial and chronological account of this exemplary project between 1999 and 2008, supplemented by discussions of agricultural development policy and descriptions of Kenyan smallholders and the project team. Taking critical and rational positions on the use of modern plant breeding techniques, biotechnology and development policy, this book is of interest to researchers and students, development agencies, NGOs and biotechnology companies.Table of Contents1: Introduction 2: Excursus on Kenya 3: The Prehistory 4: Biotechnology for the Poor 5: The First Year (1999) 6: Excursus on Independent-Minded Partners 7: The Second Year (2000) 8: 17 Dec 2000. A Farmer in Nyeri 9: The Third Year (2001) 10: 24 Nov 2001: Farmers in Machakos 11: Excursus on Plant Breeding 12: The Fourth Year (2002) 13: 25/26 Nov 2002. Farmers in Western Kenya 14: 27 Nov 2002. Farmers in the Lowlands 15: Excursus on Communications in a Rough Terrain 16: The Fifth Year (2003) 17: 15 Nov 2003. Farmers in Meru 18: Excursus on Commerce and Consumption 19: The Sixth Year (2004) 20: 21 June 2004. Farmers in Kisii 21: 7 Dec 2004. Farmers in Mwala 22: Excursus on Patents and Licenses 23: The Seventh Year (2005) 24: 6 Nov 2005. Farmers in Githunguri 25: 19 Nov 2005. Farmers in Mbeere 26: A Preliminary Assessment 27: Gleanings (2006-2008) 28: Excursus on Market Segmentation 29: 3 Nov 2008. A Farmer near Embu
£98.68
Imperial College Press Genetically Modified Crops (2nd Edition)
Book SynopsisPlant molecular biology came to the fore in the early 1980s and there has been tremendous growth in the subject since then. The study of plant genes and genomes and the development of techniques for the incorporation of novel or modified genes into plants eventually led to the commercialisation of genetically modified (GM) crops in the mid-1990s. This was seen as the start of a biotechnological revolution in plant breeding. However, plant biotechnology has become one of the hottest debates of the age and, in Europe at least, one of the greatest challenges that plant scientists have ever faced.This book covers the history and development of the science and techniques that underpin plant biotechnology. It describes the GM crops that are or have been grown commercially around the world, including failures as well as successes, and the new varieties that are being developed. The safety record of GM crops is reviewed together with the legislation that has been adopted to cover their use. The book also deals with the concerns of consumers, the GM crop debate and the prospects for the technology. In the second edition, sections on current GM crops and future developments in plant biotechnology have been greatly expanded, while those on techniques, legislation and the GM crop debate have also been updated.The book is a concise, comprehensive and readable study that is accessible to a general readership with a scientific background but also provides useful information for the specialist.Table of ContentsDNA, Genes, Genomes and Plant Breeding; The Techniques of Plant Genetic Modification; Current and Future Uses of GM Crops in Agriculture; Legislation Covering GM Crops and Foods; Issues that have Arisen in the GM Crop and Food Debate.
£62.70
Imperial College Press Genetically Modified Crops (2nd Edition)
Book SynopsisPlant molecular biology came to the fore in the early 1980s and there has been tremendous growth in the subject since then. The study of plant genes and genomes and the development of techniques for the incorporation of novel or modified genes into plants eventually led to the commercialisation of genetically modified (GM) crops in the mid-1990s. This was seen as the start of a biotechnological revolution in plant breeding. However, plant biotechnology has become one of the hottest debates of the age and, in Europe at least, one of the greatest challenges that plant scientists have ever faced.This book covers the history and development of the science and techniques that underpin plant biotechnology. It describes the GM crops that are or have been grown commercially around the world, including failures as well as successes, and the new varieties that are being developed. The safety record of GM crops is reviewed together with the legislation that has been adopted to cover their use. The book also deals with the concerns of consumers, the GM crop debate and the prospects for the technology. In the second edition, sections on current GM crops and future developments in plant biotechnology have been greatly expanded, while those on techniques, legislation and the GM crop debate have also been updated.The book is a concise, comprehensive and readable study that is accessible to a general readership with a scientific background but also provides useful information for the specialist.
£30.40
Legends Press The Unnatural Selection of Our Species
£10.44
University of Cape Town Press Genes for Africa
Book SynopsisIn Genes for Africa, Jennifer Thomson separates fact from fiction and explains why and how GM crops can help us combat poverty, starvation and disease in the developing world, in a safe and responsible way. She explains the technology, addresses controversial issues such as food safety, patents, labelling, regulation and controls and ends with a focus on Africa and possible future developments in GM technology.Trade Review"We have reassurances from those with a financial stake in GM technology that all is well and allegations from the anti-GM lobby that these organisms present a clear danger to the environment and human health. The truth, of course, is somewhere in between these two positions, and the public deserves a more factual and reliable source of information on this issue." Michael Shelby, National Institute of Environmental Health Sciences USA "True environmentalism recognises the need for development, for growing food and making livelihoods available to the poor, and aims to minimise the risks and damage. You will find the real facts discussed here and placed before you in an enthusiastic but always scientifically controlled way." George Ellis, Department of Mathematics and Applied Mathematics, UCTTable of ContentsPlant breeding & jumping genes; What is genetic modification of plants?; First generation GM crops; What's in it for the consumer?; Cost-benefit analysis - is it worth it?; GM crops & food safety; Patent or perish; The agriculture police; To label or not to label?; What's in it for Africa?; A look into the future; Index.
£14.36
Apple Academic Press Inc. Genetic Engineering: Recent Developments in
Book SynopsisThis title includes a number of Open Access chapters.A common tool in both research and agriculture, genetic engineering involves the direct manipulation of genes. Today’s areas of medical research include genetic engineering to produce vaccines against disease, pharmaceutical development, and the treatment of disease. In agriculture, genetic engineering is used to modify crops and domestic animals to increase their yields, aid in production, and enhance nutritive aspects. This important book covers new research and studies in genetic engineering in the areas of medicine and agriculture.Table of ContentsIncreased Hydrogen Production by Genetic Engineering of Escherichia coli; Use of the Red-Recombineering Method for Genetic Engineering of Pantoea Ananatis; Recombination-Mediated Genetic Engineering of a Bacterial Artificial Chromosome Clone of Modified Vaccinia Virus Ankara (MVA) Conserving, Distributing and Managing Genetically Modified Mouse Lines by Sperm Cryopreservation; c-MycERTAM Transgene Silencing in a Genetically Modified Human Neural Stem Cell Line Implanted into MCAo Rodent Brain; Evaluation of the Sensitization Rates and Identification of IgE-Binding Components in Wild and Genetically Modified Potatoes in Patients with Allergic Disorders; Genetically Modified Parthenocarpic Eggplants:Improved Fruit Productivity Under Both Greenhouse and Open Field Cultivation; Reconstitution of the Myeloid and Lymphoid Compartments After the Transplantation of Autologous and Genetically Modified CD34+ Bone Marrow Cells, Following Gamma Irradiation in Cynomolgus Macaques; Open Field Trial of Genetically Modified Parthenocarpic Tomato:Seedlessness and Fruit Quality; Design and Construction of a Double Inversion Recombination Switch for Heritable Sequential Genetic Memory; Transplantation of Genetically Engineered Cardiac Fibroblasts Producing Recombinant Human Erythropoietin to Repair the Infarcted Myocardium; Anti-Angiogenesis Therapy Based on the Bone Marrow-Derived Stromal Cells Genetically Engineered to Express sFlt-1 in Mouse Tumor Model; A Self-Inactivating Retrovector Incorporating the IL-2 Promoter for Activation-Induced Transgene Expression in Genetically Engineered T-cells; An Inducible and Reversible Mouse Genetic Rescue System; Hormone-Induced Protection of Mammary Tumorigenesis in Genetically Engineered Mouse Models; Index
£121.50
Springer Nature Switzerland AG The Date Palm Genome, Vol. 2: Omics and Molecular
Book SynopsisThis book is the first comprehensive assemblage of contemporary knowledge relevant to genomics and other omics in date palm. Volume 2 consists of 11 chapters. Part I, Nutritional and Pharmaceuticals Properties, covers the utilization of date palm as an ingredient of various food products, a source of bioactive compounds and the production of nanomaterials. Part II, Omics Technologies, addresses omics resources, proteomics and metabolomics. Part III, Molecular Breeding and Genome Modification, focuses on genetic improvement technologies based on mutagenesis, quantitative traits loci and genome editing. Part IV, Genomics of Abiotic and Biotic Stress, covers metagenomics of beneficial microbes to enhance tolerance to abiotic stress and the various genomics advances as they apply to insect control. This volume represents the efforts of 34 international scientists from 12 countries and contains 65 figures and 19 tables to illustrate presented concepts. Volume 1 is published under the title: Phylogeny, Biodiversity and Mapping. Table of Contents
£134.99
Springer International Publishing AG Animal Biotechnology 1: Reproductive
Book SynopsisThis two-volume textbook provides a comprehensive overview on the broad field of Animal Biotechnology with a special focus on livestock reproduction and breeding. The reader will be introduced to a variety of state-of-the-art technologies and emerging genetic tools and their applications in animal production. Also, ethics and legal aspects of animal biotechnology will be discussed and new trends and developments in the field will be critically assessed. The two-volume work is a must-have for graduate students, advanced undergraduates and researchers in the field of veterinary medicine, genetics and animal biotechnology.This first volume mainly focuses on artificial insemination, embryo transfer technologies in diverse animal species and cryopreservation of oocytes and embryos. Trade Review“This book is of interest to academicians and researchers in the various disciplines of life sciences, agricultural sciences, medicine, and biotechnology in universities, research institutions, and biotechnology industries. … the book achieves its goal of providing an overview of the new developments in assisted reproductive technologies.” (Juanmahel Davila, Doody's Book Reviews, July 05, 2019)Table of Contents1. Evolution of animal breeding and animal biotechnology H. Niemann and R.F. Seamark 2. Future Agricultural Animals: The Need for Biotechnology G. Seidel 3. Artificial insemination in domestic and wild animal species D. Waberski 4. Technique and Application of Sex Sorted Sperm in Domestic Farm Animals D. Rath and C. Maxwell 5. ET-technologies in domestic cattle G. Bo and R Mapletoft6. ET-technology in small ruminants S. Ledda and A. Gonzalez-Bulnes7. ET-technology in domestic pigs C. Youngs 8. ET-technologies in horses H. Sieme, J. Rau, D. Tiedemann, H. Oldenhof, L. Barros, R. Sanchez, M. Blanco, G.Martinsson, C. Herrera, D. Burger9. Endoscopy in Cattle Reproduction V. Havlicek, G. Brem, U. Besenfelder10. Transvaginal ultrasound-guided oocyte retrieval (OPU: Ovum Pick-Up) in cows and mares P. Bols and T. Stout11. Preservation of Gametes and Embryos A. Arav and J. Saragusty12. In vitro production of farm animal embryos C. Wrenzycki
£98.99
Wiley-VCH Verlag GmbH Human Genetics and Genomics: A Practical Guide
Book SynopsisFinally meeting the need for a laboratory manual on human genetics, this practical guide is the perfect companion title to all major standard textbooks on the subject. The authors all have a high-level research background and are actively involved in teaching and counseling. Based on a standard curriculum in human genetics, each chapter equals one practical unit of the course and topics range from basics in human inheritance to genetics in major disease clusters and from bioinformatics and personalized medicine to genetic counseling.Table of ContentsAbout the Authors xi Introduction xv 1 Exploring Online Genetics Sources 1 Background 1 Human Genome Project 2 National Center for Biotechnology Information (NCBI) 2 UCSC Genome Browser 3 The Encyclopedia of DNA Elements (ENCODE) 3 Roadmap Epigenomic Project 5 References 5 Exercise Questions 6 Additional Exercise Questions 11 2 Observation of Human Inheritance 13 Background 13 Mendelian Genetics 13 The Transmission of Hereditary Characteristics 16 Mendelian Disorders 19 References 20 Exercise Questions 21 Additional Exercise Questions 22 3 Reading, Understanding, and Constructing Human Pedigrees 25 Background 25 Basic Pedigree Nomenclature 26 Modes of Inheritance 26 Autosomal Recessive Inheritance 28 Pedigrees Representing Autosomal Recessive Inheritance 28 Autosomal Dominant Inheritance 29 Pedigrees Representing Autosomal Dominant Inheritance 30 X-Linked Recessive Inheritance 30 Pedigrees Representing X-Linked Recessive Inheritance 31 X-Linked Dominant Inheritance 32 Pedigrees Representing X-Linked Dominant Inheritance 32 Y-Linked Inheritance 34 Pedigrees Representing Y-Linked Inheritance 34 Non-Mendelian Patterns of Inheritance 35 Confounding Factors in Pedigree Generation and Interpretation 36 References 36 Exercise Questions 38 Additional Exercise Questions 39 4 Cytogenetics 43 Background 43 Generation of Karyograms/Chromosome Banding 45 FISH, Fluorescent In Situ Hybridization 47 Comparative Genomic Hybridization (CGH) and Array-Based CGH Technology 48 Chromosomal Abnormalities 48 Numerical Chromosomal Abnormalities 49 Structural Chromosomal Abnormalities 50 References 51 Exercise Questions 52 Additional Exercise Questions 54 5 Exploring DNA, RNA, and Protein Sequence Databases and Genome Browsers 55 Background 55 General Biological Databases 57 RNA-Specific Databases 59 Protein-Specific Databases 61 Regulatory DNA Database 62 Genome Browsers 65 References 67 Exercise Questions 67 Additional Exercise Questions 68 6 Exploring Online Bioinformatics Tools 71 Background 71 BLAST 71 ExPASy 72 Clustal Omega 74 Reactome 76 References 77 Exercise Questions 77 Additional Exercise Questions 79 7 Multifactorial Inheritance and Common Complex Diseases 81 Background 81 Polygenic Complex Diseases 82 Investigating Complex Traits 82 Obesity as a Complex Disease 83 Diabetes Mellitus Type 2 as a Complex Disease 84 Coronary Artery Diseases as Complex Diseases 85 References 86 Exercise Questions 88 Additional Exercise Questions 88 8 Neurogenetics and Behavioral Genetics 91 Background 91 Genetic Regulation of Neural Development 91 Structure and Function of the Nervous System 92 Understanding the Genetics of Neurological Disease 94 Examples of Neurogenetic Disorders 94 Huntington’s Disease 94 Parkinson’s Disease 95 Rett Syndrome 95 Behavioral Genetics 96 Genetics of Depression 97 Genetics of Drug Addiction 97 Genetics of Schizophrenia 98 References 99 Exercise Questions 100 Additional Exercise Questions 101 9 Cancer Genetics 103 Background 103 Cell Cycle and Its Regulation 104 Oncogenes and Tumor Suppressor Genes 105 Carcinogens/Environmental Factors in Cancer 107 Breast Cancer 108 Role of Molecular Medicine in Breast Cancer Treatment 110 Recent Advances in Cancer Diagnosis and Treatment 111 References 112 Exercise Questions 113 Additional Exercise Questions 114 10 Genetic Counseling 115 Background 115 References 117 Exercise Questions 117 Additional Exercise Questions 119 11 Evolving Tools in Genome Editing: CRISPR-Cas 121 Background 121 Mechanism of CRISPR-Cas9 System 123 Applications of CRISPR-Cas9 System 123 Generation of Animal Models and Engineering Cells 123 Somatic Genome Editing 124 Repair of Genetic Disorders 124 Functional Genomic Screening 124 Treatment of Infectious Diseases 125 Other Applications of CRISPR-Cas9 System 125 References 126 Acknowledgment 127 Exercise Questions 127 Additional Exercise Questions 128 Glossary 129 Index 139
£47.70
Wiley-VCH Verlag GmbH Genetik für Dummies
Book SynopsisDie Genetik ist eines der naturwissenschaftlichen Fachgebiete, deren Wissen am schnellsten wächst und deren Erkenntnisse ständig in Bewegung und in der Diskussion sind. "Genetik für Dummies" erklärt, was überhaupt hinter diesem spannenden Thema steckt. Die Autorinnen Tara Rodden Robinson und Lisa J. Spock erklären einfach und prägnant die Grundlagen der Vererbungslehre, wie beispielsweise die Mendelschen Regeln und die Zellteilung. Sie zeigen auch, wie die DNA aufgebaut ist, wie sie kopiert und richtig in Proteine übersetzt wird. Außerdem gehen sie auf die Bedeutung der Genetik in der Humanmedizin ein, wie Genmutationen entstehen und Erbkrankheiten zur Folge haben. Auch die heißen Themen wie Gentechnik, Stammzellentherapie und der Einsatz der Genetik in der Rechtsmedizin kommen nicht zu kurz.Trade Review"...Gut verständlich gibt der Titel einen Überblick über das ganze Gebiet der Genetik mit vielen Beispielen, Abbildungen und Piktogrammen. ... Ein didaktisch gut aufgebauter Titel..." (EKZ im Januar 2022)Table of ContentsÜber die Autorin 9 Über die Fachkorrektorin der 3 Auflage 10 Über die Fachkorrektorin der 4 Auflage 10 Einführung 23 Über dieses Buch 23 Konventionen in diesem Buch 24 Was Sie nicht lesen müssen 24 Törichte Annahmen über den Leser 25 Wie dieses Buch aufgebaut ist 25 Teil I: Fakten zur Genetik: Die Grundlagen 25 Teil II: DNA: Das genetische Material 25 Teil III: Genetik und Ihre Gesundheit 26 Teil IV: Genetik und Ihre Welt 26 Teil V: Der Top-Ten-Teil 26 Symbole, die in diesem Buch verwendet werden 26 Wie es weitergeht 27 Teil I: Fakten zur Genetik: Die Grundlagen 29 Kapitel 1 Was Genetik ist und warum man sich damit auskennen muss 31 Was ist Genetik? 31 Klassische Genetik: Die Weitergabe von Merkmalen von Generation zu Generation 32 Molekulargenetik: DNA und die Chemie der Gene 33 Populationsgenetik: Die Genetik einer Gruppe 34 Quantitative Genetik: Die Vererbung in den Griff kriegen 35 Aus dem Leben eines Genetikers 35 Ein Blick ins Genetiklabor 35 Arbeitsfelder in der Genetik 37 Kapitel 2 Grundlagen der Zellbiologie 43 Sehen Sie sich in Ihrer Zelle um 43 Zellen ohne Kern 44 Zellen mit Kern 45 Das Einmaleins der Chromosomen 47 Mitose: Aufspaltung 50 Schritt 1: Zeit zu wachsen 52 Schritt 2: Aufteilen der Chromosomen 53 Schritt 3: Die Teilung 55 Meiose: Zellen für die Fortpflanzung 55 Meiose, Teil I 57 Meiose, Teil II: Fortsetzung folgt 59 Mami, wo komme ich eigentlich her? 59 Kapitel 3 Erbsenzählen: Wir entdecken die Vererbungsregeln 61 Im Garten mit Gregor Mendel 62 Die Sprache der Vererbung 63 Vererbung leicht gemacht 64 Vorherrschaft sichern 65 Segregation der Allele 67 Unabhängigkeitserklärung 69 Unbekannte Allele ermitteln 69 Einfache Wahrscheinlichkeitsrechnung zur Ermittlung der vielfältigen Möglichkeiten der Vererbung 70 Lösung einfacher genetischer Probleme 72 Eine monohybride Kreuzung entschlüsseln 72 Eine dihybride Kreuzung bewältigen 73 Kapitel 4 Gesetzesvollzug: Mendels Regeln angewandt bei komplexen Merkmalen 75 Doch nicht so dominant 75 Kneifen durch unvollständige Dominanz 76 Fairplay mit Kodominanz 76 Inkonsequent – die unvollständige Penetranz 77 Allele, die Schwierigkeiten machen 78 Mehr als zwei Allele 78 Letale Allele 80 Allele, die einem das Leben schwer machen 81 Wenn Gene zusammenarbeiten 81 Versteckte Gene 82 Gekoppelte Gene 83 Ein Gen – viele Phänotypen 87 Noch mehr Ausnahmen von der (Mendel-) Regel 87 Epigenetik 87 Genomische Prägung 88 Antizipation 89 Umwelteffekte 89 Kapitel 5 Der kleine Unterschied: Genetik der Geschlechter 91 Wann ist ein Mann ein Mann? 91 Geschlechtsdetermination beim Menschen 92 Geschlechtsdetermination bei anderen Lebewesen 96 Drei sind einer zu viel: Falsche Anzahl an Geschlechtschromosomen beim Menschen 99 Zusätzliche X-Chromosomen 101 Zusätzliche Y-Chromosomen 101 Ein X und kein Y 101 Was man auf den Geschlechtschromosomen findet: Geschlechtsgekoppelte Vererbung 102 X-gekoppelte Merkmale 102 Geschlechtslimitierte Merkmale 104 Geschlechtsbeeinflusste Merkmale 104 Y-gekoppelte Merkmale 105 Teil II: DNA: Das genetische Material 107 Kapitel 6 Die DNA: Grundlage des Lebens 109 Demontage der Doppelhelix 110 Die chemischen Bestandteile der DNA 112 Die Herstellung der Doppelhelix: DNA-Struktur 115 Untersuchung verschiedener DNA-Varianten 120 Kern-DNA 120 Mitochondriale DNA 120 Chloroplasten-DNA 122 Hervorgekramt: Die Geschichte der DNA 122 Die Entdeckung der DNA 122 Chargaffs Regel unterworfen 123 Intrigen um die Helix: Franklin, Wilkins, Watson und Crick 124 Kapitel 7 Replikation: DNA auf dem Kopierer 127 Immer offen für Neues: Das DNA-Muster 128 Wie die DNA sich selbst kopiert 131 Darf ich vorstellen: Das Replikationsteam! 132 Spalten der Helix 135 Die Dinge ins Rollen bringen 136 Voreilen und Nachhinken 137 Das Puzzle setzt sich zusammen 139 Vertrauen ist gut, Kontrolle ist besser 139 Replikation bei Eukaryoten 140 Kurz angebunden: Telomere 140 Endabfertigung 142 Herr der Ringe: Replikation ringförmiger DNA 143 Theta 143 Der »rollende Kreis«: Das Rolling-Circle-Prinzip 144 D-Schleife 144 Kapitel 8 DNA-Sequenzierung 145 Ein Blick auf ein paar Genome 145 Der Weg zur humanen Gensequenz 148 Das Hefegenom 148 Der elegante Fadenwurm und sein Genom 150 Das Hühnergenom 150 Das Humangenomprojekt (HGP) 151 Sequenzierung: Die Sprache der DNA lesen 153 Die Mitspieler bei der DNA-Sequenzierung 154 Aufspüren der Botschaft in den Sequenzierungsergebnissen 155 Kapitel 9 Die RNA: Die enge Verwandte der DNA 159 Sie wissen schon einiges über die RNA 159 Der etwas andere Zucker 160 Begrüßen Sie eine neue Base: Uracil 161 Knoten und Schleifen 162 Transkription: Übersetzung der Botschaft der DNA in die Sprache der RNA 163 Fertig machen zur Transkription 164 Initiation 168 Elongation 169 Termination 170 Weiterverarbeitung nach der Transkription 171 Kappe und Schwanz dazu 171 … und Schnitt! 172 Kapitel 10 Den genetischen Code knacken 175 Das Gute am Verfall 175 Wer die Wahl hat, hat die Qual 177 Im Rahmen bleiben – oder wie man den Code liest 178 Doch nicht ganz so universell 179 Das Translationsteam stellt sich vor 179 Auf zur Translation! 180 Initiation 180 Elongation 183 Termination 184 Proteine sind wertvolle Polypeptide 187 Identifikation radikaler Gruppen 187 Proteine, in Form gepresst 187 Kapitel 11 Genexpression: Was für ein Pärchen 191 Ihre Gene in den Griff kriegen 191 Transkriptionskontrolle 194 Bevor es überhaupt losgeht 194 Stark eingebunden: Die Auswirkungen der DNA-Verpackung 195 Ferne Elemente kontrollieren Gene 196 Proteine kontrollieren die Transkription 198 Hormone machen Gene an 200 Nachbesserung: Was nach der Transkription geschehen kann 202 Schnippschnapp: Spleißen der RNA 202 Ruhe bitte! mRNA-Stilllegung 203 mRNA mit Verfallsdatum 205 Genkontrolle »Lost in Translation« 205 Ortswechsel 205 Terminverschiebung 206 Formsache 206 Prokaryotische Genexpression 208 Die Anordnung bakterieller Gene 209 Bakterielle Genexpression 209 Teil III: Genetik und Ihre Gesundheit 211 Kapitel 12 Genetische Beratung 213 Die Arbeit genetischer Berater 213 Aufstellung und Analyse eines Familienstammbaums 215 Autosomal-dominant vererbte Merkmale 217 Autosomal-rezessiv vererbte Merkmale 219 X-gekoppelte rezessive Merkmale 221 X-gekoppelte dominante Merkmale 223 Y-gekoppelte Merkmale 224 Gentests als Vorwarnung 225 Gentests – wie und warum? 225 Invasive Pränataldiagnostik 226 Nichtinvasive pränatale Testverfahren (NIPT) 227 Nach der Geburt: Das Neugeborenenscreening 228 Kapitel 13 Mutationen und Erbkrankheiten: Dinge, die man nicht ändern kann 231 Die Arten der Mutation 231 Was verursacht Mutationen? 233 Spontane Mutationen 233 Induzierte Mutationen 237 Die Folgen von Mutationen 242 Die Möglichkeiten der DNA-Reparatur 243 Einige häufige Erbkrankheiten 244 Zystische Fibrose (Mukoviszidose) 244 Sichelzellenanämie 245 Tay-Sachs-Syndrom 246 Kapitel 14 Etwas genauer hingeschaut: Die Genetik von Krebs 247 Was ist Krebs eigentlich? 247 Gutartige Tumoren: Fast harmloser Zuwachs 248 Bösartige Tumoren: Ernsthaft schlechte Nachrichten 249 Metastasen: Der Krebs auf Achse 250 Krebs als DNA-Krankheit 251 Der Zellzyklus und Krebs 252 Chromosomenanomalien – kein Geheimnis mehr 258 Analyse der verschiedenen Krebsarten 259 Erbliche Krebserkrankungen 261 Vermeidbare Krebserkrankungen 264 Kapitel 15 Chromosomenanomalien: Alles ein Zahlenspiel 267 Was Chromosomen uns verraten 268 Chromosomen zählen 268 Aneuploidie: Zusätzliche oder fehlende Chromosomen 269 Euploidie: Chromosomensätze 271 Erforschung von Chromosomenvariationen 273 Wenn Chromosomen verschwinden 274 Wenn zu viele Chromosomen vorhanden sind 274 Weitere Dinge, die bei Chromosomen schieflaufen können 278 Wie Chromosomen untersucht werden 283 Groß genug für eine sofortige Entdeckung 283 Zu klein für das bloße Auge 283 Nichtinvasives vorgeburtliches Testen auf Aneuploidie 284 Kapitel 16 Behandlung von Gendefekten mit Gentherapie 287 Linderung von Erbkrankheiten 287 Ein Gen zur richtigen Zeit am richtigen Ort 288 Viren, die ihre DNA direkt einfügen 290 Unentschieden für Adenoviren 290 Gesunde Gene werden ins Spiel gebracht 291 Unter die Lupe genommen: Die DNA-Bibliothek 293 Die Kartierung des Gens 296 Fortschritt an der Gentherapie-Front 297 Genetische Informationen für die Präzisionsmedizin nutzen 299 Pharmakogenetik (und Pharmakogenomik) 299 Cytochrom P450 und der Abbau von Medikamenten 300 Das Nebenwirkungsrisiko einer Behandlung herabsetzen 301 Die Wirksamkeit einer Behandlung erhöhen 302 Kapitel 17 Die Geschichte der Menschheit und die Zukunft unseres Planeten 305 Genetische Variation ist überall 305 Allelfrequenzen 307 Genotypfrequenzen 308 Das Hardy-Weinberg-Gesetz der Populationsgenetik 309 Die Beziehung von Allelen und Genotypen 309 Gesetzesverletzung 311 Kartierung des Genpools 313 Eine große, glückliche Familie 313 Herkunftsanalyse 314 Das geheime Sozialleben der Tiere 315 Allmähliche Formvollendung: Evolutionsgenetik 316 Der Schlüssel heißt: Genetische Variation 317 Wo neue Arten herkommen 317 So wächst der phylogenetische Baum 319 Teil IV: Genetik und Ihre Welt 321 Kapitel 18 Geheimnisse lüften mit der DNA 323 Ihre Identität steckt im DNA-Schrott 324 Spurensuche am Tatort: Wo ist die DNA? 326 Sammlung von biologischen Beweismitteln 327 Auf ins Labor! 328 Mithilfe von DNA Verbrecher dingfest machen (oder Unschuldige wieder auf freien Fuß setzen) 333 Böse Jungs mit Beweisen festnageln 333 Fehlurteile aufdecken 335 Familienfragen 336 Vaterschaftstest 336 Verwandtschaftstests 340 Kapitel 19 Genetische Veränderung: Neue Gene in Pflanzen und Tiere einbauen 345 Genetisch veränderte Organismen sind überall 345 Genetische Veränderung auf dem Bauernhof 346 Anwendung von Strahlen oder Chemikalien 348 Ungewollte genetische Veränderung 348 Auch ohne Gentechnik erfolgreich: Präzisionszucht 349 Alte Gene an neuen Orten 349 Transgene Pflanzen lassen Kontroversen wachsen 351 Der Prozess des Gentransfers bei Pflanzen 351 Mögliche kommerzielle Anwendungen 353 Abwägung der Streitpunkte 354 Folgenabschätzung 357 Ein Blick in den GVO-Zoo 358 Transgene Tiere 358 Kleinigkeiten: Transgene Insekten 362 An transgenen Bakterien herumfummeln 362 Die Blaupause verändern durch Gen-Editing 364 CRISPR/Cas9-Gen-Editing 365 Keimbahn-Gen-Editing versus somatisches Gen-Editing 366 Debatte zur Ethik des Gen-Editings 367 Kapitel 20 Klone: Sie sind ein echtes Unikat 369 Einsatz der Klone 369 Klonen von Tieren: Aus der Brust geschnitten 370 Klonen vor Dolly: Klonen mit Geschlechtszellen 370 Was an Dolly wirklich einzigartig ist 372 Klone erzeugen 373 Zwillings-Klon 373 Klone aus Körperzellen 374 Probleme beim Klonen 376 Schnelleres Altern 376 Größere Nachkommen 378 Entwicklungsstörungen 379 Umwelteffekte 380 Die Klonkriege 381 Argumente für das Klonen 381 Argumente gegen das Klonen 381 Kapitel 21 Ethische Gesichtspunkte 385 Analyse des genetischen Rassismus 386 Das perfekte Kind 387 Designerbaby auf Bestellung 387 Föten als Ersatzteillager? 388 Schon Realität: Präimplantationsdiagnostik (PID) 388 Wer weiß? Die Sache mit der Einverständniserklärung 390 Restriktionen für Gentests 391 Nur noch sichere Gentherapie 392 Für sich behalten 392 Zufallsbefunde 393 Direct-to-Consumer-entests 395 Eigentumsrechte an Genen 395 Teil V: Der Top-Ten-Teil 399 Kapitel 22 Zehn entscheidende Ereignisse in der Genetik 401 Darwins Publikation »Über die Entstehung der Arten« 401 Die Wiederentdeckung von Mendels Arbeit 402 Das transformierende Prinzip 403 Die Entdeckung der springenden Gene 404 Die Geburt der Sequenzierung 405 Die Erfindung der PCR 405 Die Entwicklung der rekombinanten DNA-Technologie.406 Die Erfindung des DNA-Fingerabdrucks.407 Die Entdeckungen in der Entwicklungsgenetik 407 Die Arbeit von Francis Collins und das Humangenomprojekt 408 Kapitel 23 Heiße Themen in der Genetik 409 Personalisierte Medizin 409 Direct-to-Consumer-Gentests 410 Gesamtexom-Sequenzierung 411 Gesamtgenom-Sequenzierung 412 Stammzellforschung 413 Das ENCODE-Projekt 414 Alternde Gene 415 Proteomik 415 Bioinformatik 416 Genchips – DNA ist nicht alles 417 Die Evolution der Antibiotikaresistenzen 418 Genetik der Infektionskrankheiten 419 Bioterrorismus 419 Kinderleicht crispern am Küchentisch? 420 Mutter Natur einfach umgehen 421 Genetik aus der Ferne 422 Kapitel 24 Kaum zu glauben: Zehn Genetik-Geschichten.423 Genmix: Wie das Schnabeltier mit allen Regeln bricht 423 Ein Name sagt mehr als tausend Worte 424 Second Life 424 Lausige Chromosomen 425 Nicht sie selbst: DNA-Chimären 425 Gene, die nur eine Mutter lieben kann 426 Ein Gen, sie alle zu beherrschen 426 Warum Alligatoren uns alle überleben könnten 427 Genetik Marke Eigenbau 427 Schrott ist gut – alles Ansichtssache 428 Stichwortverzeichnis 431 Inhaltsverzeichnis 21
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Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Genes, Genomes and Society: From Farming to Gene
Book SynopsisWith CRISPR/Cas gene editing tools in hand, we are currently experiencing a new dimension in genetic engineering. But where should the journey lead? Should we treat diseases or better repair them genetically? Will the new genetic engineering, combined with modern reproductive biology, lead to designer babies? And: May we allow a liberalization of these techniques as citizen science? New methods can precisely alter the genetic material - and they leave no traces. This gene and genome surgery thrives on increasing knowledge about the mode of action of genes, those trait-giving regions in the genome. This knowledge is being applied in practice, particularly in the breeding of more resistant and higher-yielding crops. And what about us? The author shows that gene variants have long been associated not only with diseases, but also with nutritional preferences or intelligence. Therapeutic and optimization options are close at hand. What effect does the environment have on the expression of genetic material? Genes can be shaped during a person's lifetime by the environment, nutrition or experiences and thus passed on to their offspring in a modified form. So, does society have a new form of long-term responsibility for (epi)genetic integrity? In this vividly and comprehensibly written book, the author explains the state of genetic engineering without assuming too much prior knowledge and invites an open dialogue on this ambivalent topic. Get your own idea of the fascinating yet intimidating possibilities of genetic engineering. Where do you stand on the issue? With the help of this book, you have the chance to form a differentiated opinion. This book is a translation of the original German 1st edition Generation Gen-Schere by Röbbe Wünschiers, published by Springer Fachmedien Wiesbaden GmbH, part of Springer Nature in 2019. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). The text was subsequently revised by the author. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors. Table of ContentsPreliminary thoughts.- What is genetic information? .- Breeding yesterday until today.- Read genetic material.- Edit genetic material.- Write genetic material.- Genes and society.- Rethink genetics, - And now ?.
£25.19
Agro-Bios Plant Biotechnology and Biodiversity Conservation
Book Synopsis
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World Scientific Publishing Co Pte Ltd Charting New Pathways To C4 Rice
Book SynopsisFeeding Asia in the 21st century will require a second Green Revolution. However, unlike in the first generation, future yield increases will have to be grown using less water and nitrogen in a world of unfavorable climate change — this can only be done by increasing the efficiency of the photosynthetic system, i.e. developing a C4 rice plant. If and when achieved, it would be the first nonevolutionary example of reconstructing the primary metabolism of a plant. The impact of such a scientific achievement would be undeniable, but it requires either a superb feat of genetic engineering or forced evolution.This book describes the alternative ways of achieving C4 photosynthesis in rice. Featuring contributions from leading experts, case studies are used to present views on how C4 rice might be constructed and applied, along with the socioeconomic implications that it entails. Ultimately, readers will be better informed about this highly relevant and timely topic of improving rice yield in a global environment grappling with unpredictable climate change.Table of ContentsWhy Build a New Rice Engine and Why Start Now? (J Sheehy); Hydrilla: Retrofitting a C3 Leaf with a C4 NADP-ME System (G Bowes); Balancing Light Capture with Distributed Metabolic Demand (J Evans); Redesigning C4 Rice from the Limiting C4 Photosynthesis (D-M Jiao); C4 Photosynthesis: Minor or Major Adjustments to a C3 Theme? (R Leegood); Catching Up with the Literature: What We Know Now and Didn't Then (P Mitchell); Learning from Nature to Develop Strategies for the Directed Evolution of C4 Rice (R Sage); C4 Photosynthesis and CO2 Diffusion (S von Caemmerer); and other papers.
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World Scientific Publishing Co Pte Ltd Umbilical Cord Blood: A Future For Regenerative
Book SynopsisUmbilical cord blood, previously discarded, has emerged as a new source of stem cells for hematologic reconstitution, bone marrow failures and other hematologic deficiencies. It has become increasingly clear that umbilical cord tissue contains unique stem cells of great potential for regenerative medicine. Importantly, umbilical cord blood is abundant, can be banked and transported with ease, and thus has an indisputable potential for future regenerative therapies. Driven by a massive interest for regenerative medicine and ethically acceptable stem cell sources, the scientific literature on umbilical cord stem cells has exploded.This book provides a consolidated overview of basic, translational as well as clinical research in academic institutions and industry, on hematopoietic and mesenchymal stem cells contained within umbilical cord tissue, as well as other more recently discovered stem and precursor cells of not yet fully elucidated potential. Although not discussed here, umbilical cord cells have been successfully reprogrammed into pluripotent stem cells (iPS), opening the door for a vast array of applications with this abundant human material likely catapulting cord-derived stem cells to the forefront of cell-based regenerative medicine.Suitable as a primer and reference book for medical fellows and researchers, this book can also be used by students (undergraduate and graduate) as a starting point into the vast literature on stem cells and their potential.
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World Scientific Publishing Co Pte Ltd How To Build A Dragon Or Die Trying: A Satirical
Book Synopsis'This co-authored book explores how advances in cell biology, CRISPR gene editing and bioengineering might be used to make a live dragon. The result is a gloriously tongue-in-check scientific epic … How to Build a Dragon or Die Trying is deliberately flamboyant and outrageous. It’s also funny and smart. Far from a how-to guide for ne’er-do-wells to weaponize reptiles, it is designed to spark healthy curiosity in anyone who enjoys a ripping good science read.'NatureWhat if you could have your own real dragon? While that might seem like just a fantasy, today cutting-edge science has brought us to the point where it might really be possible. This book looks into the possibilities of making living, fire-breathing dragons. The world has been fascinated with dragons for thousands of years. Fictional dragons still have a firm place in pop culture, such as Smaug from The Hobbit as well as the dragons in Game of Thrones and in the How to Train Your Dragon movies. This new book discusses using powerful technologies such as CRISPR gene editing, stem cells, and bioengineering to make real dragons. It also goes through what useful information we can learn from animals such as Pteranodons and amazing present-day creatures in our quest to build actual dragons. The book goes on to discuss the possibility of building other mythical creatures such as unicorns and mermaids. Overall, How to Build A Dragon is also meant as a satirical look at cutting-edge science, and it pokes fun at science hype. Anyone who is interested in dragons or cutting-edge science will enjoy this book! It is written in a humorous, approachable way making science fun and easy to understand, including for young adults.The author is well-known scientist Paul Knoepfler who is familiar to the public for his science, his blog The Niche, and his frequent contributions to lay stories on new science concepts such as stem cells and CRISPR. He also is known for his TED talk on designer babies with more than 1.3 million views, and his two books — . The co-author, his daughter Julie Knoepfler, is a high school student interested in science and writing. She has her own blog on literary and film analysis, and enjoys taking a humorous look at culture through writing.
£23.75
World Scientific Publishing Co Pte Ltd Gmo Sapiens: The Life-changing Science Of
Book SynopsisThis book won the INDIEFAB 2015 Bronze Award for Science (Adult nonfiction).Genetically modified organisms (GMOs) including plants and the foods made from them, are a hot topic of debate today, but soon related technology could go much further and literally change what it means to be human. Scientists are on the verge of being able to create people who are GMOs.Should they do it? Could we become a healthier and 'better' species or might eugenics go viral leading to a real, new world of genetic dystopia? GMO Sapiens tackles such questions by taking a fresh look at the cutting-edge biotech discoveries that have made genetically modified people possible.Bioengineering, genomics, synthetic biology, and stem cells are changing sci-fi into reality before our eyes. This book will capture your imagination with its clear, approachable writing style. It will draw you into the fascinating discussion of the life-changing science of human genetic modification.Table of ContentsIntroduction: GMO OMG; The History of GMOs; GMO People; The Possible Risks of GMO People; The Potential Benefits of Human Genetic Modification; The Cloning Connection; Stem Cells and GMOs; GMO Sapien Economics; Gene Therapy; GMO People in Pop Culture; GMO Myths; Big Green Men: Designer People and Eugenics; The Ethics of Human Genetic Modification;
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World Scientific Publishing Co Pte Ltd Gmo Sapiens: The Life-changing Science Of
Book SynopsisThis book won the INDIEFAB 2015 Bronze Award for Science (Adult nonfiction).Genetically modified organisms (GMOs) including plants and the foods made from them, are a hot topic of debate today, but soon related technology could go much further and literally change what it means to be human. Scientists are on the verge of being able to create people who are GMOs.Should they do it? Could we become a healthier and 'better' species or might eugenics go viral leading to a real, new world of genetic dystopia? GMO Sapiens tackles such questions by taking a fresh look at the cutting-edge biotech discoveries that have made genetically modified people possible.Bioengineering, genomics, synthetic biology, and stem cells are changing sci-fi into reality before our eyes. This book will capture your imagination with its clear, approachable writing style. It will draw you into the fascinating discussion of the life-changing science of human genetic modification.Table of ContentsIntroduction: GMO OMG; The History of GMOs; GMO People; The Possible Risks of GMO People; The Potential Benefits of Human Genetic Modification; The Cloning Connection; Stem Cells and GMOs; GMO Sapien Economics; Gene Therapy; GMO People in Pop Culture; GMO Myths; Big Green Men: Designer People and Eugenics; The Ethics of Human Genetic Modification;
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World Scientific Publishing Co Pte Ltd Unravelling Complexities In Genetics And
Book SynopsisUnravelling Complexities in Genetics and Genomics: Impact on Diagnosis Counseling and Management reviews recent advances in defining genetic and genomic factors that play important roles in diseases in humans. It includes discussions on new technologies in DNA and RNA sequencing, genome analysis, and bioinformatics applied to the study of patients with specific disorders and to normal populations, and illustrates how modern molecular techniques can improve diagnoses and enable the design of specific targeted therapies and methods of prevention. Additional emphasis is placed on the genetic variants and genomic risk factors related to the development of complex common disorders, including neurobehavioral and neurocognitive disorders in children and adults and late onset disorders in adults, including atherosclerosis, type 2 diabetes, cancer, and neurodegenerative disorders.Physicians, nurses, genetic counselors, graduate students in genetics and genomics will find this book a valuable read.Table of ContentsGenotype Phenotype Correlations; Gene Regulation; Proteomics; Epigenetics; Genome Integrity; Gene Editing; Integrating Advances in Genetics and Genomics into the Following: Disorders of Metabolism Including Diabetes and Arteriosclerosis; Neurocognitive; Neurobehavioral Disorders Neurodegeneration; Psychiatry; Immune Dysfunction; Cancer;
£82.65
