Education Books

Book SynopsisProvides an introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based approach, this book reflects the advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body.Trade Review“Overall, it could be the basis of an excellent course for junior pharmacologists in basic science research who need a greater focus on the mechanisms of drug action rather than an encyclopedic survey of clinical drug use.” (Doody’s, 26 July 2013)Table of ContentsPreface ix Abbreviations x 1 Introduction to Drug Targets and Molecular Pharmacology 1 1.1 Introduction to molecular pharmacology 1 1.2 Scope of this textbook 2 1.3 The nature of drug targets 3 1.4 Future drug targets 7 1.5 Molecular pharmacology and drug discovery 11 References 12 2 Molecular Cloning of Drug Targets 13 2.1 Introduction to molecular cloning – from DNA to drug discovery 13 2.2 ‘Traditional’ pharmacology 14 2.3 The relevance of recombinant DNA technology to pharmacology/drug discovery 14 2.4 The ‘cloning’ of drug targets 15 2.5 What information can DNA cloning provide? 20 2.6 Comparing the pharmacologic profile of the ‘cloned’ and the ‘native’ drug target 23 2.7 Reverse pharmacology illustrated on orphan GPCRs 24 2.8 Summary 27 References 27 3 G Protein-coupled Receptors 31 3.1 Introduction to G protein-coupled receptors 31 3.2 Heterotrimeric G-proteins 36 3.3 Signal transduction pathways 40 3.4 Desensitisation and down-regulation of GPCR signalling 44 3.5 Constitutive GPCR activity 45 3.6 Promiscuous G-protein coupling 47 3.7 Agonist-directed signalling 48 3.8 Allosteric modulators of GPCR function 49 3.9 Pharmacological chaperones for GPCRs 50 3.10 GPCR dimerisation 51 3.11 GPCR splice variants 63 3.12 Summary 67 References 67 Useful Web sites 70 4 Ion Channels 71 4.1 Introduction 71 4.2 Voltage-gated ion channels 73 4.3 Other types of voltage-gated ion channels 89 4.4 Ligand-gated ion channels 109 4.5 Summary 125 References 125 5 Transporter Proteins 129 5.1 Introduction 129 5.2 Classification 129 5.3 Structural analysis of transporters 132 5.4 Transporter families of pharmacological interest 133 5.5 Transporters and cellular homeostasis 167 5.6 Summary 169 References 169 6 Cystic Fibrosis: Alternative Approaches to the Treatment of a Genetic Disease 175 6.1 Introduction 175 6.2 Cystic fibrosis transmembrane conductance regulator 179 6.3 Mutations in CFTR 183 6.4 Why is cystic fibrosis so common? 184 6.5 Animal models of Cystic fibrosis 186 6.6 Pharmacotherapy 186 6.7 Gene therapy 191 6.8 Conclusion 195 References 196 7 Pharmacogenomics 201 7.1 Types of genetic variation in the human genome 201 7.2 Thiopurine S-methyltransferase and K+ channel polymorphisms 202 7.3 Polymorphisms affecting drug metabolism 204 7.4 Methods for detecting genetic polymorphisms 209 7.5 Genetic variation in drug transporters 211 7.6 Genetic variation in G protein coupled receptors 215 7.7 Summary 225 References 225 Useful Web sites 226 8 Transcription Factors and Gene Expression 227 8.1 Control of gene expression 227 8.2 Transcription factors 229 8.3 CREB 233 8.4 Nuclear receptors 238 8.5 Peroxisome proliferator-activated receptors 240 8.6 Growth factors 247 8.7 Alternative splicing 247 8.8 RNA editing 251 8.9 The importance of non-coding RNAs in gene expression 257 8.10 Summary 270 References 271 9 Cellular Calcium 277 9.1 Introduction 277 9.2 Measurement of calcium 278 9.3 The exocrine pancreas 289 9.4 Calcium signalling in pancreatic acinar cells 292 9.5 Nuclear calcium signalling 303 9.6 Conclusions 310 References 311 10 Genetic Engineering of Mice 315 10.1 Introduction to genetic engineering 315 10.2 Genomics and the accumulation of sequence data 315 10.3 The mouse as a model organism 318 10.4 Techniques for genetic engineering 319 10.5 Examples of genetically-engineered mice 332 10.6 Summary 334 References 334 11 Signalling Complexes: Protein-protein Interactions and Lipid Rafts 339 11.1 Introduction to cell signalling complexes 339 11.2 Introduction to GPCR interacting proteins 340 11.3 Methods used to identify GPCR interacting proteins 340 11.4 Functional roles of GPCR interacting proteins 345 11.5 GPCR signalling complexes 348 11.6 GPCR and ion channel complexes 355 11.7 Ion channel signalling complexes 356 11.8 Development of pharmaceuticals that target GPCR interacting proteins 356 11.9 Development of pharmaceuticals that target protein-protein interactions 356 11.10 Lipid rafts 357 11.11 Receptor-mediated endocytosis 361 11.12 Summary 364 References 364 12 Recombinant Proteins and Immunotherapeutics 367 12.1 Introduction to immunotherapeutics 367 12.2 Historical background of immunotherapeutics 368 12.3 Basis of immunotherapeutics 368 12.4 Types of immunotherapeutics 369 12.5 Humanisation of antibody therapy 372 12.6 Immunotherapeutics in clinical practice 376 12.7 Advantages and disadvantages of immunotherapy 378 12.8 The future 379 12.9 Summary 380 References 380 Glossary 381 Index 403

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Book SynopsisExperts estimate that as many as 98,000 people die in any given year from medical errors that occur in hospitals. That's more than die from motor vehicle accidents, breast cancer, or AIDSthree causes that receive far more public attention. Indeed, more people die annually from medication errors than from workplace injuries. Add the financial cost to the human tragedy, and medical error easily rises to the top ranks of urgent, widespread public problems. To Err Is Human breaks the silence that has surrounded medical errors and their consequencebut not by pointing fingers at caring health care professionals who make honest mistakes. After all, to err is human. Instead, this book sets forth a national agendawith state and local implicationsfor reducing medical errors and improving patient safety through the design of a safer health system. This volume reveals the often startling statistics of medical error and the disparity between the incidence of error and public perception of it, g

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Book SynopsisWinner of the 2011 International Society for the Study of Trauma and Dissociation (ISSTD) Pierre Janet Writing Award. A patient-oriented manual for complex trauma survivors.Trade Review"[A] book worthy of [therapists’] time." -- PsychCentral"This book is a much-welcomed tool for working with individuals with complex trauma. Although there are other training manuals that address the treatment of trauma, there is none that deal specifically with the subset of dissociative pathology. This manual is the first of its kind, a hands-on and practical training and skill-building tool for individuals and therapists. . . . The book has a user-friendly approach that is integrative and eclectic and can easily be introduced and incorporated in ongoing treatment. . . . For therapist and clients, navigating complex trauma can feel daunting and confusing with many stops and falls that may leave both feeling discouraged. This book is an anchor for the work, a place to return when uncertainty invades treatment." -- Social Work with Groups"Coping with Trauma-Related Dissociation contains the lucid explanations, practical skills, and collective wisdom of three therapists with decades of experience treating dissociative patients. This book serves as a manual for therapists, a guide for trainers, and a workbook for dissociative disorder patients, delivering an up-to-date blend of the best clinical practices with recent advances in mindfulness therapy and cognitive behavioral approaches to pathological dissociation." -- Frank W. Putnam, MD, Professor of Pediatrics and Psychiatry, University of Cincinnati College of Medicine"This book is a welcome and much-needed resource for complex dissociative clients and their therapists. It offers a myriad of exercises and strategies to help clients challenge dissociative adaptations and replace them with other means of coping, so that they can develop a more integrated self and life, and ultimately regain control of their bodies and minds." -- Christine A. Courtois, PhD, ABPP, author of Healing the Incest Wound: Adult Survivors in Therapy and Recollections of Sexual Abuse

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Book SynopsisThis book demonstrates how qualitative methods can be used to address research issues pertinent to mental health practice and psychotherapy. With contributions from leading researchers, the book examines how to review and appraise existing qualitative literature, how to choose the most appropriate method, and how to approach ethical issues.Trade Review“In a field that at times feels dominated by obfuscating jargon and a cult-like zeal, the editors have produced an accessible, illuminating text that will be of great value to those wishing to gain an introduction to this essential and developing area of mental health research.” (The British Journal of Psychiatry, 1 May 2012) "David Harper and Andrew Thompson’s book Qualitative Research Methods in Mental Health and Psychotherapy provides a reference for students and practitioners who are using qualitative research to explore topics related to mental health. The book provides a rich and comprehensive text, with contributions from specialized authors on a number of key themes and research methods relevant to qualitative research. Despite being specifically aimed at those researching mental health issues, this text would be useful for any student or practitioner who wishes to get to grips with ‘big q research’..." (Feminism and Psychology, 2013) “Since receiving this book for review, I have found myself repeatedly recommending it to fellow doctoral researchers from a range of professional backgrounds, at all stages of candidature. I do so because, in my opinion, this book addresses, in an accessible, clear, yet thorough manner, the issues which all students and practitioner-researchers face in aspiring to produce high quality, creative, qualitative research in mental health and psychotherapy.” (QMiP Bulletin Issue 15, Spring 2013) Table of ContentsAbout the Contributors. Acknowledgements. PART I Getting Started. 1 Introduction (Andrew R. Thompson and David Harper). 2 Identifying and Synthesizing Qualitative Literature (Rachel L. Shaw). 3 Ethical Issues in Qualitative Mental Health Research (Andrew R. Thompson and Eleni Chambers). 4 Participation and Service User Involvement (Alison Faulkner). 5 Qualitative Data Collection: Asking the Right Questions (Hannah Frith and Kate Gleeson). 6 Qualitative Methods for Studying Psychotherapy Change Processes (Robert Elliott). 7 Choosing a Qualitative Research Method (David Harper). PART II Methods. 8 Interpretative Phenomenological Analysis in Mental Health and Psychotherapy Research (Michael Larkin and Andrew R. Thompson). 9 Existentialist-Informed Hermeneutic Phenomenology (Carla Willig and Abigail Billin). 10 Grounded Theory Methods for Mental Health Practitioners (Alison Tweed and Kathy Charmaz). 11 Discourse Analysis (Eugenie Georgaca and Evrinomy Avdi). 12 Narrative Psychology (Michael Murray and Sally Sargeant). 13 Ethnomethodology/Conversation Analysis (Mark Rapley). 14 Q Methodological Research in Mental Health and Psychotherapy (Wendy Stainton Rogers and Phillip O. Dyson). 15 Thematic Analysis (Helene Joffe). PART III Establishing Good Quality Qualitative Research in Mental Health. 16 In Pursuit of Quality (Liz Spencer and Jane Ritchie). 17 Emerging Issues and Future Directions (David Harper and Andrew R. Thompson). Index.

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Book SynopsisAs Bowlby himself points out in his introduction to this seminal childcare book, to be a successful parent means a lot of very hard work. Giving time and attention to children means sacrificing other interests and activities, but for many people today these are unwelcome truths. Bowlbyâs work showed that the early interactions between infant and caregiver have a profound impact on an infant's social, emotional, and intellectual growth. Controversial yet powerfully influential to this day, this classic collection of Bowlbyâs lectures offers important guidelines for child rearing based on the crucial role of early relationships.Trade Review'One of the most influential forces in child psychiatry and psychology, Dr. Bowlby challenged basic tenets of psychoanalysis and pioneered methods of investigating the emotional life of children.' - The New York TimesTable of ContentsHolmes, Preface to the Routledge Classics Edition. Preface. Caring for Children. The Origins of Attachment Theory. Psychoanalysis as Art and Science. Psychoanalysis as a Natural Science. Violence in the Family. On Knowing What You Are Not Supposed To Know and Feeling What You Are Not Supposed To Feel. The Role of Attachment in Personality and Development. Attachment, Communication, and the Therapeutic Process.

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Book SynopsisPaine''s years of study and reflection on the role of religion in society culminated with this, his final work. An attack on revealed religion from the deist point of view embodied by Paine''s credo, I believe in one God, and no more its critical and objective examination of Old and New Testaments cites numerous contradictions.

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Book SynopsisThis book is one of the first to give an overview of biomechatronic exoskeletons including their applications and implications. A collective reference specifically on biomechatronic exoskeletons, an area that is relevant to mechanical and biomedical engineers as well as those working in prosthetics, rehabilitation, and defense.Table of ContentsForeword xv Preface xvii List of Contributors xix 1 Introduction to wearable robotics 1J. L. Pons, R. Ceres and L. Calderón 1.1 Wearable robots and exoskeletons 1 1.1.1 Dual human–robot interaction in wearable robotics 3 1.1.2 A historical note 4 1.1.3 Exoskeletons: an instance of wearable robots 5 1.2 The role of bioinspiration and biomechatronics in wearable robots 6 1.2.1 Bioinspiration in the design of biomechatronic wearable robots 8 1.2.2 Biomechatronic systems in close interaction with biological systems 9 1.2.3 Biologically inspired design and optimization procedures 9 1.3 Technologies involved in robotic exoskeletons 9 1.4 A classification of wearable exoskeletons: application domains 10 1.5 Scope of the book 12 References 15 2 Basis for bioinspiration and biomimetism in wearable robots 17A. Forner-Cordero, J. L. Pons and M. Wisse 2.1 Introduction 17 2.2 General principles in biological design 18 2.2.1 Optimization of objective functions: energy consumption 19 2.2.2 Multifunctionality and adaptability 21 2.2.3 Evolution 22 2.3 Development of biologically inspired designs 23 2.3.1 Biological models 24 2.3.2 Neuromotor control structures and mechanisms as models 24 2.3.3 Muscular physiology as a model 27 2.3.4 Sensorimotor mechanisms as a model 29 2.3.5 Biomechanics of human limbs as a model 31 2.3.6 Recursive interaction: engineering models explain biological systems 31 2.4 Levels of biological inspiration in engineering design 31 2.4.1 Biomimetism: replication of observable behaviour and structures 32 2.4.2 Bioimitation: replication of dynamics and control structures 32 2.5 Case Study: limit-cycle biped walking robots to imitate human gait and to inspire the design of wearable exoskeletons 33M. Wisse 2.5.1 Introduction 33 2.5.2 Why is human walking efficient and stable? 33 2.5.3 Robot solutions for efficiency and stability 34 2.5.4 Conclusion 36 Acknowledgements 36 2.6 Case Study: MANUS-HAND, mimicking neuromotor control of grasping 36J. L. Pons, R. Ceres and L. Calderón 2.6.1 Introduction 37 2.6.2 Design of the prosthesis 37 2.6.3 MANUS-HAND control architecture 39 2.7 Case Study: internal models, CPGs and reflexes to control bipedal walking robots and exoskeletons: the ESBiRRo project 40A. Forner-Cordero 2.7.1 Introduction 40 2.7.2 Motivation for the design of LC bipeds and current limitations 41 2.7.3 Biomimetic control for an LC biped walking robot 41 2.7.4 Conclusions and future developments 43 References 43 3 Kinematics and dynamics of wearable robots 47A. Forner-Cordero, J. L. Pons, E. A. Turowska and A. Schiele 3.1 Introduction 47 3.2 Robot mechanics: motion equations 48 3.2.1 Kinematic analysis 48 3.2.2 Dynamic analysis 53 3.3 Human biomechanics 57 3.3.1 Medical description of human movements 57 3.3.2 Arm kinematics 59 3.3.3 Leg kinematics 61 3.3.4 Kinematic models of the limbs 64 3.3.5 Dynamic modelling of the human limbs 68 3.4 Kinematic redundancy in exoskeleton systems 70 3.4.1 Introduction to kinematic redundancies 70 3.4.2 Redundancies in human–exoskeleton systems 71 3.5 Case Study: a biomimetic, kinematically compliant knee joint modelled by a four-bar linkage 74J. M. Baydal-Bertomeu, D. Garrido and F. Moll 3.5.1 Introduction 74 3.5.2 Kinematics of the knee 75 3.5.3 Kinematic analysis of a four-bar linkage mechanism 75 3.5.4 Genetic algorithm methodology 77 3.5.5 Final design 77 3.5.6 Mobility analysis of the optimal crossed four-bar linkage 78 3.6 Case Study: design of a forearm pronation–supination joint in an upper limb exoskeleton 79J. M. Belda-Lois, R. Poveda, R. Barberà and J. M. Baydal-Bertomeu 3.6.1 The mechanics of pronation–supination control 79 3.7 Case Study: study of tremor characteristics based on a biomechanical model of the upper limb 80E. Rocon and J. L. Pons 3.7.1 Biomechanical model of the upper arm 81 3.7.2 Results 83 References 83 4 Human–robot cognitive interaction 87L. Bueno, F. Brunetti, A. Frizera and J. L. Pons 4.1 Introduction to human–robot interaction 87 4.2 cHRI using bioelectrical monitoring of brain activity 89 4.2.1 Physiology of brain activity 90 4.2.2 Electroencephalography (EEG) models and parameters 92 4.2.3 Brain-controlled interfaces: approaches and algorithms 93 4.3 cHRI through bioelectrical monitoring of muscle activity (EMG) 96 4.3.1 Physiology of muscle activity 97 4.3.2 Electromyography models and parameters 98 4.3.3 Surface EMG signal feature extraction 99 4.3.4 Classification of EMG activity 102 4.3.5 Force and torque estimation 104 4.4 cHRI through biomechanical monitoring 104 4.4.1 Biomechanical models and parameters 105 4.4.2 Biomechanically controlled interfaces: approaches and algorithms 108 4.5 Case Study: lower limb exoskeleton control based on learned gait patterns 109J. C. Moreno and J. L. Pons 4.5.1 Gait patterns with knee joint impedance modulation 109 4.5.2 Architecture 109 4.5.3 Fuzzy inference system 110 4.5.4 Simulation 110 4.6 Case Study: identification and tracking of involuntary human motion based on biomechanical data 111E. Rocon and J. L. Pons 4.7 Case Study: cortical control of neuroprosthetic devices 115J. M. Carmena 4.8 Case Study: gesture and posture recognition using WSNs 118E. Farella and L. Benini 4.8.1 Platform description 119 4.8.2 Implementation of concepts and algorithm 119 4.8.3 Posture detection results 121 4.8.4 Challenges: wireless sensor networks for motion tracking 121 4.8.5 Summary and outlook 122 References 122 5 Human–robot physical interaction 127E. Rocon, A. F. Ruiz, R. Raya, A. Schiele and J. L. Pons 5.1 Introduction 127 5.1.1 Physiological factors 128 5.1.2 Aspects of wearable robot design 129 5.2 Kinematic compatibility between human limbs and wearable robots 130 5.2.1 Causes of kinematic incompatibility and their negative effects 130 5.2.2 Overcoming kinematic incompatibility 133 5.3 Application of load to humans 134 5.3.1 Human tolerance of pressure 134 5.3.2 Transmission of forces through soft tissues 135 5.3.3 Support design 138 5.4 Control of human–robot interaction 138 5.4.1 Human–robot interaction: human behaviour 139 5.4.2 Human–robot interaction: robot behaviour 140 5.4.3 Human–robot closed loop 143 5.4.4 Physically triggered cognitive interactions 146 5.4.5 Stability 147 5.5 Case Study: quantification of constraint displacements and interaction forces in nonergonomic pHR interfaces 149A. Schiele 5.5.1 Theoretical analysis of constraint displacements, d 150 5.5.2 Experimental quantification of interaction force, Fd 151 5.6 Case Study: analysis of pressure distribution and tolerance areas for wearable robots 154J. M. Belda-Lois, R. Poveda and M. J. Vivas 5.6.1 Measurement of pressure tolerance 155 5.7 Case Study: upper limb tremor suppression through impedance control 156E. Rocon and J. L. Pons 5.8 Case Study: stance stabilization during gait through impedance control 158J. C. Moreno and J. L. Pons 5.8.1 Knee–ankle–foot orthosis (exoskeleton) 159 5.8.2 Lower leg–exoskeleton system 159 5.8.3 Stance phase stabilization: patient test 160 References 161 6 Wearable robot technologies 165J. C. Moreno, L. Bueno and J. L. Pons 6.1 Introduction to wearable robot technologies 165 6.2 Sensor technologies 166 6.2.1 Position and motion sensing: HR limb kinematic information 166 6.2.2 Bioelectrical activity sensors 171 6.2.3 HR interface force and pressure: human comfort and limb kinetic information 175 6.2.4 Microclimate sensing 179 6.3 Actuator technologies 181 6.3.1 State of the art 181 6.3.2 Control requirements for actuator technologies 183 6.3.3 Emerging actuator technologies 185 6.4 Portable energy storage technologies 189 6.4.1 Future trends 189 6.5 Case Study: inertial sensor fusion for limb orientation 190J. C. Moreno, L. Bueno and J. L. Pons 6.6 Case Study: microclimate sensing in wearable devices 192J. M. Baydal-Bertomeu, J. M. Belda-Lois, J. M. Prat and R. Barberà 6.6.1 Introduction 192 6.6.2 Thermal balance of humans 192 6.6.3 Climate conditions in clothing and wearable devices 193 6.6.4 Measurement of thermal comfort 194 6.7 Case Study: biomimetic design of a controllable knee actuator 194J. C. Moreno, L. Bueno and J. L. Pons 6.7.1 Quadriceps weakness 195 6.7.2 Functional analysis of gait as inspiration 195 6.7.3 Actuator prototype 197 References 198 7 Communication networks for wearable robots 201F. Brunetti and J. L. Pons 7.1 Introduction 201 7.2 Wearable robotic networks, from wired to wireless 203 7.2.1 Requirements 203 7.2.2 Network components: configuration of a wearable robotic network 205 7.2.3 Topology 206 7.2.4 Wearable robatic network goals and profiles 208 7.3 Wired wearable robotic networks 209 7.3.1 Enabling technologies 209 7.3.2 Network establishment, maintenance, QoS and robustness 213 7.4 Wireless wearable robotic networks 214 7.4.1 Enabling technologies 214 7.4.2 Wireless sensor network platforms 216 7.5 Case Study: smart textiles to measure comfort and performance 218J. Vanhala 7.5.1 Introduction 218 7.5.2 Application description 220 7.5.3 Platform description 221 7.5.4 Implementation of concepts 222 7.5.5 Results 222 7.5.6 Discussion 223 7.6 Case Study: ExoNET 224F. Brunetti and J. L. Pons 7.6.1 Application description 224 7.6.2 Network structure 224 7.6.3 Network components 224 7.6.4 Network protocol 225 7.7 Case Study: NeuroLab, a multimodal networked exoskeleton for neuromotor and biomechanical research 226A. F. Ruiz and J. L. Pons 7.7.1 Application description 226 7.7.2 Platform description 227 7.7.3 Implementation of concepts and algorithms 227 7.8 Case Study: communication technologies for the integration of robotic systems and sensor networks at home: helping elderly people 229J. V. Martí, R. Marín, J. Fernández, M. Nuñez, O. Rajadell, L. Nomdedeu, J. Sales, P. Agustí, A. Fabregat and A. P. del Pobil 7.8.1 Introduction 230 7.8.2 Communication systems 230 7.8.3 IP-based protocols 232 Acknowledgements 233 References 233 8 Wearable upper limb robots 235E. Rocon, A. F. Ruiz and J. L. Pons 8.1 Case Study: the wearable orthosis for tremor assessment and suppression (WOTAS) 236E. Rocon and J. L. Pons 8.1.1 Introduction 236 8.1.2 Wearable orthosis for tremor assessment and suppression (WOTAS) 236 8.1.3 Experimental protocol 239 8.1.4 Results 240 8.1.5 Discussion and conclusions 241 8.2 Case Study: the CyberHand 242L. Beccai, S. Micera, C. Cipriani, J. Carpaneto and M. C. Carrozza 8.2.1 Introduction 242 8.2.2 The multi-DoF bioinspired hand prosthesis 242 8.2.3 The neural interface 245 8.2.4 Conclusions 247 8.3 Case Study: the ergonomic EXARM exoskeleton 248A. Schiele 8.3.1 Introduction 248 8.3.2 Ergonomic exoskeleton: challenges and innovation 250 8.3.3 The EXARM implementation 251 8.3.4 Summary and conclusion 254 8.4 Case Study: the NEUROBOTICS exoskeleton (NEUROExos) 255S. Roccella, E. Cattin, N. Vitiello, F. Vecchi and M. C. Carrozza 8.4.1 Exoskeleton control approach 257 8.4.2 Application domains for the NEUROExos exoskeleton 258 8.5 Case Study: an upper limb powered exoskeleton 259J. C. Perry and J. Rosen 8.5.1 Exoskeleton design 259 8.5.2 Conclusions and discussion 268 8.6 Case Study: soft exoskeleton for use in physiotherapy and training 269N. G. Tsagarakis, D. G. Caldwell and S. Kousidou 8.6.1 Soft arm–exoskeleton design 270 8.6.2 System control 272 8.6.3 Experimental results 275 8.6.4 Conclusions 277 References 278 9 Wearable lower limb and full-body robots 283J. Moreno, E. Turowska and J. L. Pons 9.1 Case Study: GAIT–ESBiRRo: lower limb exoskeletons for functional compensation of pathological gait 283J. C. Moreno and J. L. Pons 9.1.1 Introduction 283 9.1.2 Pathological gait and biomechanical aspects 284 9.1.3 The GAIT concept 285 9.1.4 Actuation 286 9.1.5 Sensor system 286 9.1.6 Control system 286 9.1.7 Evaluation 287 9.1.8 Next generation of lower limb exoskeletons: the ESBiRRo project 289 9.2 Case Study: an ankle–foot orthosis powered by artificial pneumatic muscles 289D. P. Ferris 9.2.1 Introduction 289 9.2.2 Orthosis construction 290 9.2.3 Artificial pneumatic muscles 291 9.2.4 Muscle mounting 291 9.2.5 Orthosis mass 292 9.2.6 Orthosis control 292 9.2.7 Performance data 292 9.2.8 Major conclusions 295 9.3 Case Study: intelligent and powered leg prosthesis 295K. De Roy 9.3.1 Introduction 296 9.3.2 Functional analysis of the prosthetic leg 297 9.3.3 Conclusions 303 9.4 Case Study: the control method of the HAL (hybrid assistive limb) for a swinging motion 304J. Moreno, E. Turouska and J. L. Pons 9.4.1 System 305 9.4.2 Actuator control 305 9.4.3 Performance 306 9.5 Case Study: Kanagawa Institute of Technology power-assist suit 308K. Yamamoto 9.5.1 The basic design concepts 308 9.5.2 Power-assist suit 308 9.5.3 Controller 310 9.5.4 Physical dynamics model 310 9.5.5 Muscle hardness sensor 310 9.5.6 Direct drive pneumatic actuators 311 9.5.7 Units 311 9.5.8 Operating characteristics of units 312 9.6 Case Study: EEG-based cHRI of a robotic wheelchair 314T. F. Bastos-Filho, M. Sarcinelli-Filho, A. Ferreira, W. C. Celeste, R. L. Silva, V. R. Martins, D. C. Cavalieri, P. N. S. Filgueira and I. B. Arantes 9.6.1 EEG acquisition and processing 315 9.6.2 The PDA-based graphic interface 317 9.6.3 Experiments 317 9.6.4 Results and concluding remarks 318 Acknowledgements 319 References 319 10 Summary, conclusions and outlook 323J. L. Pons, R. Ceres and L. Calderón 10.1 Summary 323 10.1.1 Bioinspiration in designing wearable robots 324 10.1.2 Mechanics of wearable robots 326 10.1.3 Cognitive and physical human–robot interaction 327 10.1.4 Technologies for wearable robots 328 10.1.5 Outstanding research projects on wearable robots 329 10.2 Conclusions and outlook 330 References 332 Index 335

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Book SynopsisThe Book of Common Prayer is the old and well-loved prayer book of the Church of England, in use since the 16th century. It has also become one of the classic English texts, its prayers and expressions helping to mould the English language into what it is today. Cambridge''s new editions of the Prayer Book have been freshly typeset for the 21st century, using a modern digital typeface to give a clear printing image and greater readability. Nevertheless the format and page layout of this book follow the earlier Large-Print Edition Prayer Book page for page. It provides the complete 1662 services including the traditional forms of the baptism and marriage services. The prayer book comes in a burgundy imitation leather hardback binding and will be helpful for anyone needing slightly larger print for ease of reading.

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Book SynopsisFrom a bestselling author, an incendiary and uproarious assault on the pretensions of scientific atheists (National Review)Militant atheism is on the rise. Prominent thinkers including Richard Dawkins, Sam Harris, Daniel Dennett, and Christopher Hitchens have published best-selling books denigrating religious belief. And these authors are merely the leading edge of a larger movement that includes much of the scientific community. In response, mathematician David Berlinski, himself a secular Jew, delivers a biting defense of religious thought. The Devil''s Delusion is a brilliant, incisive, and funny book that explores the limits of science and the pretensions of those who insist it is the ultimate touchstone for understanding our world.

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Book SynopsisMany want a simple life, but find it difficult to actually live that way. They fight a constant battle to balance work, family, friends, and other demands on schedules stretched too thin. Joyce Meyer breaks it down to the simple principle of exercising faith rather than doubt and confidence rather than people-pleasing. She writes from her experience of struggling to balance work, family, friends, and all the other demands on limited time to show readers the simple answer to a simpler life.Joyce gives these and other practical and easy to implement ideas for finding real joy: Live to glorify God Let go of what lies behind Choose your battles Don''t be afraid of what people think Trust God to change other people Live with margin Don''t be so hard on yourself Stop doing things you don''t do well Remember that God is for you.Joyce reminds readers th

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Book SynopsisHow to understand the clients you have, not just their DSM checklists.

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Book Synopsis"An invaluable portrait of the evolution of international health in recent decades." —William Bynum, Wall Street JournalTrade Review"An invaluable portrait of the evolution of international health in recent decades…We need more people like Peter Piot who will rise to the occasion with spirit and passion." -- William Bynum - Wall Street Journal"[A] fascinating account of the complex behavioural responses that epidemics trigger among their human hosts." -- José Esparza - Nature"From laboratories to field epidemiology, boardrooms and political chambers, [No Time To Lose] charts an incredibly impactful career in science and the fine arts of diplomacy, communication and political engagement in difficult situations." -- Chikwe Ihekweazu - Nature"Insightful." -- Andrew Jack - Financial Times"A riveting read." -- Laurie Garrett - The Lancet"A timely and accessible memoir…enthralling reading…will appeal to budding young scientists." -- Booklist (starred review)"Piot helped assure that affordable drugs revolutionizing AIDS treatment would be available to the poorest victims. He leaves a legacy of change and hope in two worlds—medicine and politics—and an urgent reminder that their cooperation saves lives." -- Publishers Weekly (starred review)

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Book SynopsisThe Wave is based on a true incident that occured in a high school history class in Palo Alto, California, in 1967.The powerful forces of group pressure that pervaded many historic movements such as Nazism are recreated in the classroom when history teacher Burt Ross introduces a new system to his students. And before long The Wave, with its rules of strength through discipline, community, and action, sweeps from the classroom through the entire school. And as most of the students join the movement, Laurie Saunders and David Collins recognize the frightening momentum of The Wave and realize they must stop it before it's too late.

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Book SynopsisProvides an account of the principles and practice of the basic techniques of plastic and reconstructive surgery that various surgeons should know. This title discusses the management, repair and reconstruction of defects and wounds using skin and other tissues and reviews potential problems and complications.Trade Review"Fundamental Techniques of Plastic Surgery remains one of our standard textbooks to be recommended to all trainees"British Journal of Plastic Surgery is no substitute. This text is concise, clear and well written. It is an excellent up to date source of information for all residents and plastic surgeons."Journal of the Royal College of Surgeons of Edinburgh chapters are certainly concise and describe each basic technique with precision and clarity. This helps to make the book easier to carry and this can be particularly useful reading for the trainee wherever they find themselves." "Overall, this book is incredibly useful for the Plastic Surgery trainee in helping them to develop the basic knowledge they will need to accompany the clinical experience they gain on the wards and in theatre."" Riaz Agha, Executive Editor, The Journal of Surgery; President, Guy's, King's and St Thomas' Surgical Society, July 2003 of current edition: "The chapters are certainly concise and describe each basic technique with precision and clarity. This helps to make the book easier to carry and this can be particularly useful reading for the trainee wherever they find themselves." "Overall, this book is incredibly useful for the Plastic Surgery trainee in helping them to develop the basic knowledge they will need to accompany the clinical experience they gain on the wards and in theatre."" Riaz Agha, Executive Editor, The Journal of Surgery; President, Guy's, King's and St Thomas' Surgical Society, July 2003Table of ContentsPART 1 BASIC TECHNIQUES 1. Wound management 2. The Z-plasty 3. Free skin grafts 4. Flaps 5. Additional techniques PART 2 SURGICAL APPLICATIONS 6. Hypertrophic scars and keloids 7. Radiation injury 8. Pressure sore management 9. Limb trauma 10. Neoplastic conditions 11. Hand surgery

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Book SynopsisThis book challenges the conventional security-based international policy frameworks that have developed for dealing with HIV/AIDS during and after conflicts, and examines first-hand evidence and experiences of conflict and HIV/AIDS.Since the turn of the century international policy agenda on security have focused on HIV/AIDS only as a concern for national and international security, ignoring people's particular experiences, vulnerabilities and needs in conflict and post-conflict contexts. Developing a gender-based framework for HIV/AIDS-conflict analysis, this book draws on research conducted in Burundi to understand the implications of post-conflict demobilization and reintegration policies on women and men and their vulnerability to HIV/AIDS. By centring the argument on personal reflections, this work provides a critical alternative method to engage with conflict and HIV/AIDS, and a much richer understanding of the relationship between the two.InteTable of ContentsIntroduction 1. Context, Conflict and Expereinces 2. Gender Relations 3. Gender Relations in the Conflict 4. Discontents of Re-integration 5. HIV/AIDS in People’s Lives 6. International Expert Knowledge and Its Production 7. People’s Voices 8. Communities of Policy and Communities of Everyday Life Conclusion

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Book SynopsisAn autobiography of a modern day mystic, an Irish woman with powers of the saints of old. It presents the testimony of a woman who sees things, beyond the range of our everyday experience.Trade ReviewThose who see angels are close to being angels. In this book, Lorna beautifully and graphically describes angels and how they workAngels in my Hair is more than just an autobiography. It is a revelation that will open your eyes and change your life. Angels in My Hair has a message that the world needs to hearLorna's wisdom and insights are breathtaking. This is a woman I have known for many years and admire enormously. She has made a big difference to my life and that of many othersIn times of universal deceit, never more so than now, the world needs guidance and hope. Angels in My Hair is an amazing book by an incredible woman, who shares her unique and fascinating experience of the guides at work with her in her own life and the messages they have for us allNobody is going to argue with her underlying message of love and compassion and forgiveness and her hopes for "peace among nations and peace in families". Spending time with her is both challenging and inspirational * The Irish Times *

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Book SynopsisThis print edition of The EACVI Textbook of Echocardiography comes with a DVD and access to the online version on Oxford Medicine Online, for as long as the edition is published by Oxford University Press. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge, and download all the figures and tables. This fully updated second edition of the official textbook of the European Association of Cardiovascular Imaging serves the educational requirements of cardiologists and all clinical medical professionals in echocardiography. It is fully-aligned with EACVI goals and reflects the core European syllabus. Published in partnership with the European Society of Cardiology and written by a team of expert authors, this textbook is a valuable resource on echocardiography and for accreditation through the EACVI. With its thorough and instructive text complemented by more than 500Trade Review"This will be a valuable resource for the study of clinical echocardiography. It will be of particular benefit to those individuals wishing to adhere to the curriculum endorsed by the European Association of Echocardiography." Doody's NotesTable of ContentsBASIC INSTRUMENTATION AND MODALITIES; CARDIAC MORPHOLOGY, HAEMODYNAMICS AND PHYSIOLOGY; DISEASE ECHOCARDIOGRAPHIC ASSESSMENT; DISEASE ECHOCARDIOGRAPHIC ASSESSMENT; SPECIFIC CLINICAL CONTEXT / ENVIRONMENT; MISCELLANEOUS

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Book SynopsisThe bestselling authors of the groundbreaking Artisan Bread in Five Minutes a Day bring you a cookbook with 90 delicious, entirely gluten-free bread recipes made from easy-to-find ingredients--a perfect gift for health conscious foodies and bakers! With more than half a million copies of their books in print, Jeff Hertzberg, MD and Zoë François have proven that people want to bake their own bread, so long as they can do it quickly and easily. But what about people with celiac disease or gluten sensitivity? They want to eat well too, but gluten is everywhere: in cakes, pastas, desserts, gravyeven in beer and Scotch whiskey. But the thing they miss most? Bread.Based on overwhelming requests from their readers, Jeff Hertzberg and Zoë François have returned to their test kitchens to create an entirely gluten-free bread cookbookmost of the recipes that readers loved in Artisan Bread in Five Minutes a Day appear here in a gluten-free version. In just f

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Book SynopsisAutPlay Therapy is a behavioral play-based treatment approach to working with children and adolescents with autism spectrum disorder and other developmental disabilities. This innovative new model contains a parent-training component (wherein the therapist trains parents to do directive play therapy interventions in the home) and can be utilized in any setting where children and adolescents with an autism disorder, ADHD, dysregulation issues, or other neurodevelopmental disorders are treated. This comprehensive resource outlines the AutPlay Therapy process and offers a breakdown of treatment phases along with numerous assessment materials and over 30 directive play therapy techniques.Table of ContentsIntroduction. 1 Autism Spectrum Disorder. 2 Developmental Disabilities. 3 Influences on AutPlay Therapy. 4 Play Therapy. 5 Behavioral Therapy. 6 AutPlay Therapy Approach. 7 Emotional Regulation Ability 8 Social Skills Development. 9 Connection (Relationship Development). 10 Parent Training. 11 Phases of AutPlay Therapy. 12 AutPlay Follow Me Approach. 13 Research. 14 Case Studies. 15 Emotional Regulation Interventions. 16 Social Skills Interventions. 17 Connection Interventions. Appendix A: Therapy Inventories. Appendix B: Therapy Treatment Plan Profile. Appendix C: Additional Play Based Treatments. Appendix D: Apps for Autism and Developmental Disorders. Appendix E: Additional Resources.

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Book SynopsisWhen it was first published in France in 1961 as Folie et DÃraison: Histoire de la Folie à l'Ãge Classique, few had heard of a thirty-four year old philosopher by the name of Michel Foucault. By the time an abridged English edition was published in 1967 as Madness and Civilization, Michel Foucault had shaken the intellectual world. This translation is the first English edition of the complete French texts of the first and second edition, including all prefaces and appendices, some of them unavailable in the existing French edition. History of Madness begins in the Middle Ages with vivid descriptions of the exclusion and confinement of lepers. Why, Foucault asks, when the leper houses were emptied at the end of the Middle Ages, were they turned into places of confinement for the mad? Why, within the space of several months in 1656, was one out of every hundred people in Paris confined?Shifting brilliantly from Descartes and early EnlighTrade Review'One of the major works of the twentieth century is finally available in English. This comprehensive translation finally overcomes one of the great divisions within the world of reason; an occasion to revisit Madness and Civilization as it was written.’ – Paul Rabinow, University of California, Berkeley, USA‘Now, at last, English speaking readers can have access to the depth of scholarship that underpins Foucault’s analysis: I have no doubt that this long awaited translation will have a transformative effect on a new generation of readers.’ - Nikolas Rose, London School of Economics, UK'…we are in the presence of a principal thesis that is truly original, by a man whose personality, whose intellectual "dynamism", whose talent for exposition all qualify him for high education' - Henri Gouhier, Principal Examiner of Foucault's Thesis' ... it returns a fragment of 'nature' to history and transforms madness, something we take to be a medieval phenomenon, into a phenomenon of civilization.' - Roland Barthes'Without a shadow of a doubt, the most original, influential and controversial text in this field during the last forty years. It remains as challenging now as on first publication. Its insights have still not been fully appreciated and absorbed.' - Roy Porter'This is quite an exceptional book of very high calibre - brilliantly written, intellectually rigorous, and with a thesis that thoroughly shakes the assumptions of traditional psychiatry.' - R.D. Laing'Extraordinary…rich and insistent, and almost unreasonable in its necessary repetitions.' - Maurice Blanchot'This magnificent book…requires a mind that is capable of being in turn a historian, a philosopher, a psychologist, and a sociologist-never simply one of these…This is not a method that could be offered as an example; it is not within the reach of just anybody. Something more than talent is necessary.' - Fernand Braudel, Annales'I have just finished reading your great book…You are a real explorer.' - Gaston Bachelard, in a letter to Michel Foucault'Scarcely any philosopher working on the history of philosophy, or historian working on the history of institutions, social science or sexuality can avoid confronting the challenge of Foucault's books.' - Michael Ignatieff, Times Literary Supplement'Scarcely any philosopher working on the history of philosophy, or historian working on the history of institutions, social science or sexuality can avoid confronting the challenge of Foucault's books.' - Michael Ignatieff, Times Literary Supplement'Without a shadow of a doubt, the most original, influential and controversial text in this field during the last forty years. It remains as challenging now as on first publication. Its insights have still not been fully appreciated and absorbed.' – Roy Porter'Extraordinary…rich and insistent, and almost unreasonable in its necessary repetitions.' – Maurice BlanchotTable of ContentsForeword: History and Significance of Foucault’s History of Madness Prefaces 1. 1961 Edition 2. 1972 Edition Part 1 1. Stultifera Navis 2. The Great Confinement 3. The Correctional World 4. Experiences of Madness 5. The Insane Part 2 1. The Madman in the Garden of Species 2. The Transcendence of Delirium 3. Figures of Madness 4. Doctors and Patients Part 3 1. The Great Fear 2. The New Division 3. The Proper Use of Liberty 4. Birth of the Asylum 5. The Anthropological Circle Appendices 1. Réponse à Derrida (Michel Foucault Derrida e no kaino Paideia (Tokyo) February 1972) 2. La Folie, l'absence d'oeuvre Appendix 1 of 1972 Edition 3. Mon corps, ce papier, ce feu Appendix 2 of 1972 Edition Notes Bibliography Critical Bibliography on Foucault’s History of Madness

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Book SynopsisPublisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.Comprehensive, single-source coverage of the entire first year of medical school!Table of ContentsContributing AuthorsFaculty ReviewersPrefaceAcknowledgmentsHow to Use This BookHow to ContributeChapter 1: Anatomy and HistologyCellular Anatomy and HistologyGross Anatomy and HistologyChapter 2: Behavioral ScienceEpidemiologyStatisticsDisease PreventionEthicsLife CyclePsychologyChapter 3: BiochemistryMolecular BiologyNucleotide SynthesisMutations and DNA RepairEnzymesThe CellConnective TissueHomeostasis and MetabolismAmino AcidsNutritionFed Versus Unfed StateLaboratory Tests and TechniquesGeneticsChapter 4: EmbryologyChapter 5: MicrobiologyBacteriologySpirochetesMycologyParasitologyVirologyMicrobiology: SystemsAntimicrobialsChapter 6: ImmunologyPrinciples of ImmunologyPathologyChapter 7: PathologyChapter 8: General PharmacologyPharmacodynamicsPharmacokineticsToxicologyIndexAbout the Editors

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Book SynopsisWhat you are doing I cannot do, what I’m doing you cannot do, but together we are doing something beautiful for God, and this is the greatness of God’s love for us.” —Mother Teresa, from Where There Is Love, There Is God In this book, Mother Teresa’s relationship with God and her commitment to those she served—the poorest of the poor—is powerfully explored in her own words. Taken largely from her private lessons to her sisters, published here for the first time, Where There Is Love, There Is God unveils her extraordinary faith in, and surrender to, God’s will.Love is perhaps the word that best summarizes Mother Teresa’s life and message. She sought to be an extension of God’s heart and hands in today’s world. She was called to be a missionary of charity, a carrier of God’s love to each person she met, especially those most in need. Yet she did not think that t

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Book SynopsisA revelatory exploration of the Jewish roots of the Last Supper that seeks to understand exactly what happened at Jesus’ final Passover.   “Clear, profound and practical—you do not want to miss this book.”—Dr. Scott Hahn, author of The Lamb’s Supper and The Fourth Cup    Jesus and the Jewish Roots of the Eucharist shines fresh light on the Last Supper by looking at it through Jewish eyes. Using his in-depth knowledge of the Bible and ancient Judaism, Dr. Brant Pitre answers questions such as: What was the Passover like at the time of Jesus? What were the Jewish hopes for the Messiah? What was Jesus’ purpose in instituting the Eucharist during the feast of Passover? And, most important of all, what did Jesus mean when he said, “This is my body… This is my blood”? To answer these questions, Pitre explores ancient Jewish beliefs about the

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Book SynopsisChanging the parent-child dynamic to improve anxiety symptoms.Trade Review"What loving parent would not want to end the suffering of their child? Yet anxiety will run roughshod over families, taking advantage of responses that, on the surface, seem so caring. By the time they arrive in treatment, parents feel helpless and exhausted, while the worried child has become dependent on reassurance and overprotection. McCurry expertly elucidates for readers the tactics of therapeutic change that will stabilize the family system, empower the parents, and foster resilience in the child." -- Reid Wilson, PhD, co-author Anxious Kids, Anxious Parents: Seven Ways to Stop the Worry Cycle and Raise Courageous and Independent Children "Work with parents of anxious children is becoming richer and more nuanced as practitioners used to doing parent training, communication skills work, and traditional cognitive behavior therapy begin to use acceptance and mindfulness-based therapies as well. This wise and well-written volume will help provide that sense of nuance and balance. It is not a treatment protocol, nor is it dedicated to any one approach; it is a guidebook, helping you to use your existing skills in more sophisticated ways and to learn new skills and approaches without having to abandon what you already know. Highly recommended." -- Steven C. Hayes, PhD, Co-developer of Acceptance and Commitment Therapy and author of Get Out of Your Mind and Into Your Life "This book is an incredibly valuable resource for every clinician working with anxious children and their parents. McCurry expertly integrates evocative clinical vignettes with a sophisticated, yet easily understood, biopsychosocial model. He explains the negative parent-child interactions so common in the families of anxious youth and provides an elegant and effective therapeutic approach for enhancing family communication and resolving conflict. Drawing from the cognitive-behavioral, functional analytic, acceptance, and mindfulness literatures, this book provides clear guidance and an abundance of clinical "pearls" for teaching parents how to create a healthy and resilient home environment." -- John Piacentini, PhD, ABPP, President, Society for Clinical Child and Adolescent Psychology, Director, Child OCD, Anxiety, and Tic Disorders Program, UCLA Semel Institute

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Book SynopsisBorn out of the excitement of a convergence of ideas and passions, this book provides a synthesis of the work of researchers, clinicians, and theoreticians who are leaders in the field of trauma, attachment, and psychotherapy.Trade Review"Trauma has returned to center stage in our clinical and theoretical thinking. This book enriches our understanding of trauma from all the pertinent perspectives. It will be invaluable for all in the field, both for treating people and thinking about trauma. " -- Daniel S. Stern, MD, Adjunct Professor of Psychiatry, Cornell Medical School; author of The Interpersonal World of the Infant"This remarkable collection of articles summarizes much of the best current thinking on trauma, attachment research, neurobiology, and its application to psychodynamic psychotherapy. It is an outstanding achievement." -- Beatrice Beebe, PhD, Clinical Professor of Psychology in Psychiatry, NYS Psychiatric Institute, Columbia University"This volume provides much more than a compelling set of models for healing trauma—it also delivers a state of the art account of the causes and consequences of trauma. The editors, Marion Solomon and Daniel Siegel, are to be congratulated for bringing together so cohesively some of the most powerful voices in the field. This book will clarify understanding of trauma through eight chapters presenting the latest significant findings in neuroscience, developmental and clinical psychology, and psychiatry. Those training or working with victims of trauma and their families will find this resource indispensable." -- Howard Steele, PhD, Director, Attachment Research Unit, University College, London; Editor, Attachment & Human Development"This is an extraordinary book. It provides an up-to-the-minute integration of attachment trauma and neuroscience. Each contribution provides an essential chart to guide the therapist in understanding this most difficult group of clients. Taken together, the chapters compose a veritable atlas mapping this world of the unbearable and unthinkable. Without such theoretical and practical guides, the therapist working with trauma can become as vulnerable as the client she or he attempts to heal." -- Peter Fonagy, PhD, FBA, Freud Memorial Professor of Psychoanalysis at University College London and Director, Child and Family Center, The Menninger Clinic, Topeka, KS

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Book SynopsisThe properties and function of human communication.

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Book SynopsisIn this work, Karen Horney explores the basic structure of neuroses in the context of their cultural assumptions.

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Book SynopsisThis synoptic history of the life and teachings of Christ was originally published in 1890 as an aid for clergymen and other instructors in biblical texts. James combines the four gospel accounts of the life of Jesus into one useful text with scriptural references in the margins for accurate study and quotation, complete with a list of individual variations among the sources. Written in the language of the Revised Version, this book will be useful to anyone involved in Bible study or with an interest in Christian theology.Table of ContentsPreface; Note on the Sermon on the Mount; Note on the marginal references; Tables to find any passage; Table of our Lord's miracles; Table of our Lord's parables; Table of our Lord's principal discourses; The gospel history; Variations; References to sections in S. D. Waddy's harmony.

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Book SynopsisAn accessible, passionate indictment of the ignorance, opportunism and social indifference that enriched lawyers and a few plaintiffs, though the available scientific evidence was against them. New York Times Book Review, Notable Books of 1996Trade Review"[A] sober and rigorous examination of the controversy over silicone breast implants . . . an important statement, not just about silicone implants, but about other matters at the intersection of law, science, and opinion. [Dr. Angell’s] book is . . . a warning that rationality, like much else in the fragile porcelain of society, can be weakened by lack of vigilance." -- New York Times"An indispensable guide to the breast implant madness—litigation that will forever stand as a monument to the inability of our civil justice system to sort out latter-day Ptolemies from Galileos." -- Wall Street Journal"Marcia Angell's outstanding book explains clearly and fairly the combination of greed, fear, ignorance, junk science, and media hype that created this national litigation nightmare. Everyone interested in the tort system, science, and medicine should heed the lessons that Dr. Angell teaches." -- Shirley M. Hufstedler, former U.S. Secretary of Education

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Book Synopsis9780990505099.

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Book SynopsisProviding a practical and accessible guide, this book enables readers to quickly build up knowledge and understanding of toxicology applications taking the reader from basic theory to an advanced basics level dealing with specific issues like pesticides, alcohol, and cigarettes.Table of ContentsForeword xxi Preface xxiii Acknowledgment xxv 1 Welcome to the World of Toxicology 1 1.1 Chemicals – They Are All Around Us 1 1.2 Synthetic or Naturally Occurring Chemicals – Which Are “Safer”? 1 1.3 Chemical Control Regulations 2 1.4 Perception of Chemical Risk 3 1.5 Why Is Toxicology Important? 4 1.6 Summary 4 2 Basic Toxicological Terminology 5 2.1 The Cell 5 2.1.1 Stem Cells, Somatic Cells, and Germ Cells 5 2.2 Homeostasis7 2.3 Adaptation and Cell Injury 7 2.4 Cellular Responses to Injury 7 2.5 Mode of Action and Mechanism of Action 9 2.6 Adverse Effects 9 2.7 Biological and Statistical Significance 10 2.8 Local and Systemic Effects 11 2.9 How Chemicals Cause Harm 11 2.10 Acute and Chronic Exposures 12 2.11 Chemical Interactions in Mixtures 14 2.12 Summary 15 3 The Dose Makes the Poison 19 3.1 Dose– Response and Dose–Effect Relationships 19 3.2 Internal and External/Exposure Dose 20 3.3 The Dose Makes the Poison: Dose–Response/Effect Curves 21 3.4 No Observed Adverse Effect Level (NOAEL) 23 3.5 Lowest Observed Adverse Effect Level (LOAEL) 24 3.6 What Affects the NOAEL and LOAEL? 24 3.7 No Observed Effect Level (NOEL) 24 3.8 Summary 24 4 Toxicokinetics 27 4.1 Why Is Toxicokinetics So Useful? 28 4.2 ADME: Absorption, Distribution, Metabolism, and Excretion 29 4.3 Biotransformation (Metabolism) 36 4.4 Bioavailability and Area Under the Curve (AUC) 38 4.5 Assessment Approaches 39 4.6 Summary 40 5 Factors That Modify Toxicity 45 5.1 Lifestyle Factors – Alcohol and Tobacco 45 5.2 Influence of Age 46 5.3 Health Status 46 5.4 Nutritional Status – Diet 47 5.5 Sex 48 5.6 Adaptation 48 5.7 Genetic Variability 48 5.8 Summary 49 6 Local Effects 53 6.1 Irritants and Corrosives 53 6.2 Skin Structure 54 6.3 Irritant Contact Dermatitis 56 6.4 Chemical Corrosives 60 6.5 The Skin as a Target Organ – Severity of Effect 60 6.6 Chemical Irritants and Other Exposure Routes 61 6.7 Summary 62 7 Systemic Effects 65 7.1 Chemical Allergies 66 7.2 Genetic Toxicology 79 7.3 Carcinogenicity 91 7.4 Reproductive and Developmental Toxicology 100 7.4.10 Maternal Mediated Toxicity 119 8 Target Organ Toxicity 123 8.1 The Liver 124 8.2 The Kidney 139 8.3 The Immune System 151 8.4 Hematopoietic System and Blood 167 8.5 The Nervous System 176 8.6 The Respiratory Tract 196 8.7 The Endocrine System 208 9 Assessment Methods 227 9.1 Assessment of Irritation and Corrosive Effects 228 9.2 Assessment of Acute Toxicity 239 9.3 Repeated 9.4 Assessment of Carcinogenicity 259 9.5 Assessment of Genetic Toxicity 267 9.6 Assessment of Reproductive and Developmental Effects 283 9.7 Assessment of Skin and Respiratory Sensitization 295 10 Alternative Methods to Animal Testing 307 10.1 The Drive for Alternative Methods 307 10.1.1 A Different Approach? 308 10.3 In Vitro and Ex Vivo Methods 308 10.4 Twenty‐ First Century Toxicity Testing 310 10.5 Physicochemical Data and Their Use in Hazard Identification and Exposure Assessment 314 10.6 Summary 317 11 Human Health Risk Assessment 321 11.1 Human Health Risk Assessments – Prospective and Retrospective 321 11.2 Risk, Hazard, and Exposure 322 11.3 Chemical Risk Assessments 323 11.4 Linear Dose Response – Nonthresholded Effects 333 11.5 Exposure Assessment 336 11.6 Risk Characterization – Do We Have a Problem? 340 11.7 Summary 341 Glossary 345 Index 355

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Book SynopsisThe revised edition of this indispensable resource presents the tools clients need to learn and practice any Dialectical Behavior Therapy (DBT) skill or set of skills. Clients get quick access to the materials recommended for a particular skills training program, with more than 225 reproducible handouts and worksheets in all. In the revised edition, handouts and worksheets for each skill are grouped together, making the book even easier to use. All four DBT skills modules are included--mindfulness, interpersonal effectiveness, emotion regulation, and distress tolerance--each with a brief introduction written expressly for clients. In a convenient, spiral-bound 8 1/2 x 11 format, the book is updated throughout with more inclusive language and changes in technology and daily life.

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Book SynopsisHow can you make the most of retirement? How should you plan for retirement? What are the challenges of retirement and how can they be dealt with?This new edition of The Psychology of Retirement looks at this life stage as a journey that involves challenges, opportunities, setbacks, periods of disenchantment and, often, exciting new beginnings. Updates include a new chapter on the âold ageâ stage of life as well as end-of-chapter tips and things to think about, case studies of retirees and pre-retirees, and new statistics including the effects of COVID and homeworking. Taking a positive approach, the book explores how retirement provides opportunities to cultivate new friendships, interests and hobbies, consolidate and renegotiate long-held ones, and even re-invent oneself in a post-work environment. It also emphasizes the value of pre-retirement planning, and the importance of establishing new goals and purposes.Retirement can be a period of significant psychological growth and development, and The Psychology of Retirement shows how it can herald the beginning of a vibrant and active stage of life.

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Book SynopsisThe archaeological remains in the Gulf area are astounding, and still relatively unexplored. Michael Rice has produced the first up-to-date book, which encompasses all the recent work in the area. He shows that the Gulf has been a major channel of commerce for millenia, and that its ancient culture was rich and complex, to be counted with its great contempororaries in Sumer, Egypt and south-west Persia.Table of ContentsList of Illustrations, Introduction, Preface, Acknowledgements, 1 THE ARABIAN GULF IN ANTIQUITY, 2 THE PROGRESS OF GULF ARCHAEOLOGY, 3 CLIMATE, SEA-LEVELS, MAN AND HIS COMPANIONS, 4 DILMUN, THE ANCIENT CULTURE OF THE GULF, 5 THE POLITY OF THE ANCIENT GULF, 6 THE MYTHS OF SUMER AND DILMUN, 7 BAHRAIN: THE BLESSED ISLAND, 8 DILMUN’S NEIGHBOURING LANDS, 9 THE MERCHANTS OF DILMUN, 10 GILGAMESH, THE GULF AND THE LAND OF THE LIVING, 11 THE ENIGMA OF DILMUN, The Chronology of the Arabian Gulf, Abbreviations, Notes, Bibliography, Index

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Book SynopsisThe gynecology of young girls and teenagers provides exacting challenges. Intimate examination can be daunting for the patient, and the balance between parental permission and patient privacy shifts as menstruation and sexual activity begins.Table of ContentsPreface, xi Contributors, xiii SECTION 1 PREPUBERTAL GIRLS, 1 Part 1 Introduction 1 Initial assessment, 3 Maureen Lynch Part 2 Prepubertal Girls: Symptoms and Signs 2 Ambiguous genitalia in the neonate and infant, 6 Sejal Shah and Avni C. Shah 3 Vaginal discharge and odor, 14 Corinne Bazella and Majorie Greenfield 4 Vaginal bleeding, 18 Valerie S. Ratts 5 Ovarian masses, 22 Julie L. Strickland and Anne-Marie Priebe Part 3 Prepubertal Girls: Gynecologic Conditions 6 Labial adhesions, 29 Jane E. D. Broecker 7 Pediatric vulvovaginitis, 33 Sari Kives 8 Sexual abuse, 38 Nancy D. Kellogg and James L. Lukefahr SECTION 2 CONCERNS IN PREPUBERTAL GIRLS AND IN ADOLESCENTS, 43 Part 1 External Genitalia 9 Normal hymen and hymenal variations, 45 Amy D. DiVasta and Estherann Grace 10 Vulvar signs and symptoms, 49 10.1 Overview of vulvar signs and symptoms, 49 Paula J. Adams Hillard 10.2 Vulvar ulcers and aphthosis, 57 Helen R. Deitch 10.3 Vulvar tumors, cysts, and masses, 60 Meredith Loveless 10.4 Vulvar abscesses, 64 Jennie Yoost and S. Paige Hertweck 11 Vulvar lichen sclerosus, 69 Paula J. Adams Hillard 12 Accidental trauma, 72 Mariel A. Focseneanu and Diane F. Merritt 13 Female genital mutilation, 76 Katherine A. Zakhour and Comfort Momoh Part 2 Puberty 14 Normal puberty, 80 Jennifer C. Kelley and Frank M. Biro 15 Precocious puberty, 87 Paul B. Kaplowitz 16 Delayed puberty, 91 Sara E. Watson, Peter A. Lee and Christopher P. Houk SECTION 3 ADOLESCENT GIRLS, 97 Part 1 Adolescent Health 17 Initial assessment: consultation with an adolescent girl, 99 Paula J. Adams Hillard 18 Confidentiality, 103 Janice Bacon and Jennifer A. Greene 19 Legal issues, 108 Rebecca Gudeman and Abigail English 20 Adolescent sexuality, 114 Linda M. Kollar 21 Adolescent preventive care for healthy teens, 119 Kristin L. Kaltenstadler and Corinne Lehmann 22 Weight, 125 22.1 Overweight and obesity and gynecologic conditions, 125 Stephanie Crewe and Maria Trent 22.2 Eating disorders, 131 Anne Hsii and Neville H. Golden 23 The female athlete, 138 James R. Ebert 24 Immunizations, 142 Amy B. Middleman 25 Substance abuse: screening and brief intervention, 146 Patricia Schram and Sharon Levy 26 Suicidal ideation and self-harm: screening, 151 Matthew B. Wintersteen and Christopher V. Chambers 27 Healthcare for lesbian, bisexual, and transgender adolescents, 154 Elizabeth B. Erbaugh and Margaret J. Blythe 28 Developmental delay, 158 Lisa Allen and Melanie Ornstein 29 Menstrual health, 163 29.1 Tampons and menstrual hygiene products, 163 Stephanie Stockburger and Hatim A. Omar 29.2 Normal menses, 166 Paula J. Adams Hillard 29.3 Menstrual suppression, 169 Kelly Kantartzis and Gina Sucato 30 The gynecologic exam, 174 30.1 When and how to perform a gynecologic exam, 174 Paula J. Adams Hillard 30.2 Cervical cytology screening, 180 Paula J. Adams Hillard 31 Sexually-transmitted disease screening, 183 Michael G. Spigarelli Part 2 Pregnancy Prevention and Options 32 Unintended pregnancy: options and counseling, 187 Kaiyti Duffy and Rachael Phelps 33 Contraceptive counseling, 192 33.1 Contraceptive counseling for healthy teens, 192 Stephanie B. Teal 33.2 Contraceptive counseling for teens with medical illness, 197 Melissa Gilliam and Amy Whitaker 34 Contraception, 205 34.1 Barrier methods, 205 Uri Belkind and Susan M. Coupey 34.2 Oral contraception, 210 Emily M. Godfrey and Melissa Kottke 34.3 Transdermal and vaginal combination methods, 217 Sherine Patterson-Rose and Paula Braverman 34.4 Intrauterine devices, 222 Sophia Yen 34.5 Progestin-only contraception, 226 Michelle M. Isley and Andrew M. Kaunitz 34.6 Emergency contraception, 230 Kaiyti Duffy and Melanie A. Gold Part 3 Adolescent Girls: Symptoms and Signs 35 Hirsutism, 234 Dianne Deplewski and Robert L. Rosenfield 36 The breast, 241 36.1 Breast concerns, 241 Kaylene J. Logan and Eduardo Lara-Torre 36.2 Breast discharge, 246 Donald E. Greydanus and Colleen Bryzik Dodich 37 Vaginal discharge, 249 Seema Menon, Mandakini Sadhir, and Susan Jay 38 Pelvic masses, 254 Noam Smorgick-Rosenbaum and Elisabeth H. Quint 39 Gynecologic pain, 260 39.1 Pelvic and abdominal pain, 260 Geri D. Hewitt 39.2 Myofascial (musculoskeletal) pain, 266 John Jarrell 40 Amenorrhea, 269 Melanie Nathan and Andrea L. Zuckerman 41 Abnormal uterine bleeding, 275 Jennifer E. Dietrich and Jennifer L. Bercaw-Pratt 42 Premenstrual syndrome/premenstrual dysphoric disorder and mood disorders, 281 Michael Dobbs and Paula Braverman Part 4 Adolescent Girls: Gynecologic Conditions 43 Vulvovaginal conditions, 285 43.1 Yeast/candida, 285 Sofya Maslyanskaya and Elizabeth Alderman 43.2 Bacterial vaginosis, 289 Jennifer Louis-Jacques and Rebecca Flynn O’Brien 44 Sexually-transmitted diseases, 293 44.1 Genital herpes, 293 Terri Warren 44.2 Human papillomavirus and condyloma, 297 Lea E. Widdice and Jessica A. Kahn 44.3 Chlamydia, 302 Taraneh Shafii and Gale R. Burstein 44.4 Gonorrhea, 307 Bree Weaver and J. Dennis Fortenberry 44.5 Trichomonas, 312 Samantha E. Montgomery and Jill S. Huppert 44.6 HIV, 315 Anita Radix and Donna Futterman 44.7 Other sexually-transmitted diseases, 318 Ellen S. Rome 45 Dysmenorrhea, 325 Michelle Forcier and Zeev Harel 46 Congenital anomalies, 330 Amy M. Vallerie and Lesley L. Breech 47 Ectopic pregnancy, 339 Michelle Vichnin 48 The ovaries, 342 48.1 Ovarian cysts, 342 Paula J. Adams Hillard 48.2 Ovarian germ cell tumors, 348 Claire Templeman 49 Endometriosis, 351 Mary Anne Jamieson 50 Polycystic ovary syndrome, 355 Samantha M. Pfeifer 51 Pelvic infl ammatory disease, 361 Colleen McNicholas and Jeffrey F. Peipert 52 Gonadal dysgenesis, 366 Courtney A. Marsh and Yolanda R. Smith 53 Sexual assault and date rape, 371 Beth L. Emerson and Kirsten Bechtel Appendix 1 Essential information, 375 Appendix 2 Useful web resources for adolescents, their parents/caregivers, and clinicians, 389 Index, 391

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Book SynopsisMany people know that in 1928 Alexander Fleming discovered penicillin''s antibiotic potential while examining a stray mould that had bloomed in a dish of bacteria in his London laboratory. But few realise that Fleming worked only fitfully on penicillin until 1935, and that he is merely one character in the remarkable story of the antibiotic''s development as a drug. The others are Howard Florey, Professor of Pathology at Oxford University, where he ran the Dunn School; the German Jewish emigre and biochemist Ernst Chain; and Norman Heatley, one of the few scientists in Britain capable of the micro-analysis of organic substances. It was these three men and their colleagues at the Dunn School who would battle a lack of money, a lack of resources and even each other to develop a drug that would change the world. It was these three men and their colleagues who would be almost forgotten. Why this happened, why it took fourteen years to develop penicillin, and how it was finally done, is a story of quirky individuals, missed opportunities, medical prejudice, brilliant science, shoestring research, wartime pressures and misplaced modesty.Trade ReviewAdmirable, superbly researched ... Perhaps the most exciting tale of science since the apple dropped on Newton's head * Simon Winchester, NEW YORK TIMES *Veteran journalist and author Lax takes a revealing look back at the time when world-altering science was done on a shoestring, bringing to brilliant life the story of the first great antibiotic ... Informative and thoroughly enjoyable science history * KIRKUS REVIEWS *[Lax] tells the stories of these four remarkable scientists adroitly . . . and reinserts them into their rightful place in scientific history. * INDEPENDENT ON SUNDAY *A fascinating story of serendipity, wounded egos and medical myths. * GUARDIAN *

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Book SynopsisConsiders the origins, development and history of medicines that generate high media interest and have a huge social and economic impact on society. This title provides coverage of pre-twentieth century drugs, the huge advances made in the twentieth century and the developments in drug research.Trade Review"... the book is of great value for everybody wanting to get brief, reliable information as well as for those using it as a starting point for further research." Die Pharmazie - An International Journal of Pharmaceutical SciencesTable of ContentsChapter 1 Introduction. Part 1 Legacy Of The Past. Chapter 2 The Prehistoric Period. Chapter 3 Pre-Hellenic Civilisations. Chapter 4 Greece and Rome. Chapter 5 The Arab World. Chapter 6 Herbals. Chapter 7 Chemical Medecines. Chapter 8 Systematic Medicine. Part 2 Drugs From Naturally Occurring Prototypes. Section I Phytochemicals. Chapter 9 Alkaloids. Chapter 10 Non-Alkaloid Plant Products. Chapter 11 Plant Product Analogues and Compounds Derived From Them. Section II Biochemicals. Chapter 12 The Origins Of Hormone Therapy. Chapter 13 Neurohormones. Chapter 14 Peptide Hormones. Chapter 15 Sex Hormones. Chapter 16 Adrenal Cortex Hormones. Chapter 17 Prostaglandins. Chapter 18 Hormone Analogues. Chapter 19 Vitamins. Chapter 20 Antimetabolites. Chapter 21 Blood and Biological Products. Section III Drugs from Microorganisms. Chapter 22 Antibiotics. Chapter 23 Antibiotic Analogues. Chapter 24 Pharmacodynamic Agents from Microorganisms. Chapter 25 Analogues of Pharmacodynamic Agents from Fungi. Part 3 Synthetic Drugs. Chapter 26 The First Synthetic Drugs and Their Analogues. Chapter 27 Drugs Originating from the Screening of Dyes. Chapter 28 Drugs Originating from the Screening of Organic Chemicals. Chapter 29 Drugs Discovered through Serendipitous Observations Involving Humans. Chapter 30 Drugs Disocvered through Serendipity in the Laboratory. Chapter 31 Concluding Remarks.

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Book SynopsisConsiders the typological background to ordained ministry some have drawn from the Old Testament and what ministry meant to the earliest Christian communities. Explores the ordination rites and theology of the early church, the Christian East, the medieval West, the churches of the Reformation, and the post-Tridentine Roman Catholic Church.

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Book SynopsisThe Divine Dance is a superb book from bestselling author and spiritual teacher Richard Rohr, exploring the doctrine of the Trinity and how it can transform our relationship with God.Trade ReviewFinding the sweet spot where contemporary science meets ancient mysticism, and theology meets poetry, The Divine Dance sketches a beautiful choreography for a life well–lived. In our joy or our pain, true life is always relational, a flow, a dance. (And was always meant to be.) -- Bono, U2The Divine Dance is not only Richard Rohr’s best book; it’s the best book on the Trinity I’ve ever read. Tender, human, both pastorally and psychologically brilliant, this is the work Rohr was born to do . . . An instant spiritual classic. -- Jonathan Martin, Author, How to Survive a ShipwreckRohr and Morrell have given us a liberating and yet totally orthodox invitation into the life of God. This book is a celebration of the Trinity, not as bad math (1+1+1=3), and not as baffling mystery to avoid, but as the divine movement of love. The Divine Dance is an example of why Rohr has had such a profound influence on so many Christians seeking to balance reason and mystery, action and contemplation, not to mention faith and real life. -- Nadia Bolz-Weber, Pastor, House for All Sinners and Saints, Author, Accidental Saints: Finding God in All the Wrong People, NadiaBolzWeber.comThe Divine Dance invites you into the heart of Christian mysticism: the lavish ever-expanding love of God. Richard Rohr and Mike Morrell show how the triune God is more than a philosophical concept—the Trinity is a joyous celebration of love and life, and we are all called to participate. -- Carl McColman, Author, The Big Book of Christian Mysticism, CarlMcColman.netA truly vital re-presentation of the fundamental truths that lie at the heart of the Christian gospel for a new age. Rohr and Morrell have written a soon-to-be classic that will re-enchant many with the beauty of the Christian tradition while causing us to expand and explore beyond the boundaries of rigid religiosity . . . a must-read for every Christian in the twenty-first century. -- Brandan Robertson, Author, Nomad: A Spirituality for Travelling LightWith the wisdom of C.S. Lewis and the accessibility of Rob Bell, Richard Rohr and Mike Morrell unpack our long-lingering questions about God, love, grace, and forgiveness, all through the lens of Trinitarian spirituality. This isn’t to say that this book answers every question. Like all good mystics, Rohr and Morrell circle our questions, reveling in the mystery of all that is. Join them. Stand with them "under the waterfall of God’s infinite mercy, and know that you are loved." -- David James Poissant, L.A. Times Book Prize Finalist; author, The Heaven of Animals, davidjamespoissant.comRichard Rohr is one of the great spiritual masters of our time, indeed of any time. His superb new book on the Trinity is vintage Rohr: clearheaded, provocative, inspiring, challenging, and, most of all, suffused with the presence of the Holy Spirit. The Trinity will of course always remain a profound mystery, but after reading Father Rohr’s book, you will experience it as a mystery that can, and will, transform your life. -- James Martin, SJ, Author, Jesus: A Pilgrimage and Seven Last WordsRichard Rohr has once again given us a remarkable book on a sub­ject that most Christians haven’t really thought about or prayed about, and yet we all agree is at the very heart of Christianity . . . [Richard's] heart is to reform Christianity from the bottom up by making clear the very shape of God, and in The Divine Dance he does just that . . the wisdom contained within these pages will enable us all to join in the dance of life! -- Francis MacNutt, Healing minister and author, The Healing Reawakening, christianhealingmin.orgMore and more people are struggling with conventional understandings of God, like the big white guy on a throne with a long beard and a fistful of swords and lightning bolts by which you (or your enemies) might be smitten at any moment if you don’t think or act correctly. For many, the concept of Trinity simply triples their God-problems. But in The Divine Dance, Richard Rohr and Mike Morrell explore the Trinity as a pathway beyond problematic understandings of God. This beautifully-written book can do far more than change your troubled thoughts about God: it can change your way of thinking about God entirely. -- Brian D. McLaren, Activist, speaker, and author, We Make the Road by Walking, brianmclaren.netThis is Christianity, awake. In The Divine Dance, Fr. Rohr and Mike Morrell inspire the mind and open the heart by exploring how a more robust Trinitarian theology can enliven faith in a way that’s rooted not only in Christian tradition, but in wisdom, experience, and love. -- Michael Gungor, Musician and author, The Crowd, the Critic, and the Muse, GungorMusic.comAn inspiring book whose richness is possibly best savoured when read intermittently, allowing it to become part of one’s own process of prayer. * Reform Magazine, May issue *an imaginative, provocative, and energised invitation to be renewed in the Trinitarian faith * Church Times *

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Book SynopsisIf Mr. Mitchell gives an eloquent account of the effects of Job''s poetry in his introduction, in the translation itself he does even better: he makes those effects come alive. Writing with three insistent beats to the line, and hammering home a succession of boldly defined images, he achieves a rare degree of vehemence and concentration. — John Cross, New York TimesThe Book of Job pulses with moral energy, outrage, and spiritual insight; it is nothing less than human suffering and the transcendence of it.Now, The Book of Job has been translated into English by the eminent translator and scholar Stephen Mitchell, whose versions of Rilke, Israeli poetry, and the Tao Te Ching have been widely praised. This is the first time ever that the Hebrew verse of Job has been translated into verse in any language, ancient or modern, and the result is a triumph.

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Book SynopsisThe teachings of the German–born Meister Eckhart (1260–1328), Dominican philosopher and spiritual master, are among the most daring and profound in the history of Western mysticism. From counsels on discernment to a treatise on detachment as the most essential virtue, Eckhart''s fascinating thoughts on the spiritual life will inspire and challenge those looking to deepen their experience of God.

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