Education Books

Book SynopsisFrom the French Abbey of St Wandrille to the abandoned and awesome Rock Monasteries of Cappadocia in Turkey, the celebrated travel writer Patrick Leigh Fermor studies the rigorous contemplative lives of the monks and the timeless beauty of their monastic surroundings. In his occasional retreats, the peaceful solitude and the calm enchantment of the monasteries was passed on as a kind of ''supernatural windfall'' which A Time to Keep Silence so effortlessly records.Trade ReviewThe English language is still a superb instrument in the hands of a writer who has a virtuoso skill with words, a robust aesthetic passion, an indomitable curiosity and a rapturous historical imagination * Observer *The genius of Patrick Leigh Fermor is a many splendoured thing. Soldier, traveller, writer, Phihellene ... he has already dazzled and delighted ... It is some time since more truth and beauty were distilled into a hundred pages * Stewart Perowne *A brilliant book * Sunday Times *Delightful ... His book is not only an admirable piece of travel writing; it is also a brilliant piece of human exploration * New Statesman *Introspection, history, reportage have their balanced places in a well-written book ... measured and lucent * Sunday Times *Patrick Leigh Fermor is a stylish, superb master of words, which he savours like the choicest vintage * The Times *What a delight it is to read a book so beautifully and sensitively written * Observer *A most successful attempt to portray the reactions of the man of the world (in the literal sense) when confronted with the monastic life * Daily Telegraph *Delightful, lucidly written work of introspection that evokes the hardship and the rewards of the solitary life, as well as its beauty * The Glasgow Herald *John Murray is doing the decent thing and reissuing all of Leigh Fermor's main books ... But what else would you expect from a publisher whose commitment to geography is such that for more than two centuries it has widened our understanding of the world? * Geographical Magazine *A pleasure and an instruction to read * Irish Times *Bringing the landscape alive as no other writer can, he uses his profound and eclectic understanding of cultures and peoples ... to paint vivid pictures - nobody has illuminated the geography of Europe better * Geographical Magazine *

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Book SynopsisJP Morgan's Best Summer Read 2018We are in the midst of a sleep deprivation crisis, and this has profound consequences on our health, our job performance, our relationships and our happiness. In this book, Arianna Huffington boldly asserts that what is needed is nothing short of a sleep revolution. Only by renewing our relationship with sleep can we take back control of our lives.Through a sweeping, scientifically rigorous and deeply personal exploration of sleep from all angles, Arianna delves into the new golden age of sleep science that reveals the vital role sleep plays in our every waking moment and every aspect of our health from weight gain, diabetes, and heart disease to cancer and Alzheimer's. In The Sleep Revolution, Arianna shows how our cultural dismissal of sleep as time wasted not only compromises our health and our decision-making but also undermines our work lives, our personal lives and even our sex lives. She explores all the latest science on what exactly is going on while we sleep and dream. She takes on the dangerous sleeping pill industry and confronts all the ways our addiction to technology disrupts our sleep. She also offers a range of recommendations and tips from leading scientists on how we can achieve better and more restorative sleep, and harness its incredible power.In today''s fast-paced, always-connected, perpetually harried and sleep-deprived world, our need for a good night's sleep is more important and elusive than ever. The Sleep Revolution both sounds the alarm on our worldwide sleep crisis and provides a detailed road map to the great sleep awakening that can help transform our lives, our communities and our world.

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Book SynopsisMost people either give their past pains and experiences too little or too much importance and power. Pastor and biblical counselor Stephen Viars explores the role of the past as God intended and offers readers biblical examples and practical, encouraging steps toward a transformed today and a hope-filled future.Trade Review“The Christian counseling world has waited a long time for a book that has substantive help for people who are weighed down with problems from their past. It is finally here! Steve Viars has taken a difficult issue and, aptly and with clarity, applies practical theological answers to it. You cannot read this book without being personally changed. If you are looking for solid biblical answers about your past, this is the book for you.”—Dr. John D. Street, chair of the Master of Arts in Biblical Counseling program, The Master’s College and Seminary“The gospel promises believers the power to change, but those who’ve experienced deep pain in their past often struggle with living by faith. Pastor Steve Viars’ new book, Putting Your Past in Its Place, offers practical, compassionate, biblical help for those with painful personal histories, and for their pastors and counselors.”—Dr. Laura Hendrickson, author, biblical counselor, psychiatrist“Steve Viars is a pastoral psychologist of the best sort: realistic, practical, and thoroughly Christian. His book really does put the past in its proper place and does so by comforting, challenging, and encouraging those who need to make peace with their past. Whether you are struggling with the past yourself or one who counsels the strugglers, you cannot read this book and not be changed.”—Sam R. Williams, PhD, associate professor of counseling, Southeastern Baptist Theological Seminary, Wake Forest, NC“Many of us remain paralyzed by our past even though freedom from our past was purchased on the cross. In this much-needed book, Steve Viars shows that the Bible teaches us what we need to know about learning from and disarming our past. So read well, see yourself, see Jesus, and receive His liberating grace.”—Paul Tripp, president, Paul Tripp Ministries and author of What Did You Expect? Redeeming the Realities of Marriage“If you long to get free from your past and into the glorious future God has for you, Steve Viars and his wonderful new book, Putting Your Past in Its Place, can show you the way. It is insightful, powerful, and immensely practical. Get one for every member of your family so they can join you in this bright new future free from the pain of your past.”—Dr. James MacDonald, senior pastor of Harvest Bible Chapel, Chicago“In Putting Your Past in its Place, experienced biblical counselor and respected Bible scholar Steve Viars seeks to answer the important question, What role does a person’s past play in his or her present-day living? Viars bases his answer not on his or any other human being’s opinion but on God’s authoritative, infallible Word. This interesting and insightful book will be of great benefit to many people. Counselors will find this book to be very helpful, as will Christians who struggle with discerning a biblical perspective.”—Wayne Mack, professor of biblical counseling, Grace School of Ministry, Pretoria and Capetown, South Africa“As a counselor I know people often get stuck in the past. Some wallow there and others make every effort to deny its effects. While Steve Viars boldly admits the importance of the past, he gives it no mystical power of causality for the redeemed. He is thoroughly biblical, pleasantly practical, and sets the record straight about how to handle your past in a God-honoring way. I challenge you to read this book with your own past in mind—then put your past in its place so you can help others do the same.”—Garrett Higbee, executive director of Twelve Stones Ministries and team leader of counseling ministry, Harvest Bible Chapel, Rolling Meadows, IL“Steve Viars knows the problems we face, but he also knows that the answers to our problems are found in the Bible. In Putting Your Past in its Place, he takes his wealth of experience in the pulpit and in the counseling room and applies it to the difficulties faced by those who feel shackled to their past. If you want to deal with your past and yes, put it in its proper place, then this book is for you. It is thoroughly biblical, deeply compassionate, and engagingly hopeful. Buy it!”—Elyse Fitzpatrick, head of Women Helping Women Ministries and author of Overcoming Fear, Worry, and Anxiety

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Book SynopsisNoted psychologist Dr. Edith Fiore explains how to detect spirit possession in yourself and others, how to protect yourself from entities, how to release your home from displaced spirits, and how to perform a depossession. Filled with shocking case histories.

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Book SynopsisPublished here for the first time in English, this is Carl Schmitt's last book. Carl Schmitt is widely acknowledged to be one of the most important and influential political theorists of the 20th Century. His work has been taken up and much discussed by political theorists in the last few years.Trade Review“Why study Schmitt? Like the great thinkers of all ages, he addressed issues that transcend the moment. Political philosophers and political theorists, constitutional lawyers and legal theorists, international relations theorists ideologues of all colors find answers to burning political questions that revolve around the concept of sovereignty.” George Schwab, National Committee on American Foreign Policy and The City University of New York (City College and Graduate Center) “The publication in English of Carl Schmitt’s Political Theology II constitutes an important event in the Anglo-American reception of Schmitt’s thought. In the late 1960s, as the Roman Catholic Church reconciled itself with secular modernity and West Germany’s liberal democracy resorted to extra-legal measures in the midst of political crisis, Schmitt decided to revisit the questions that motivated his thinking in the early Weimar Republic: can morality only find justification in transcendental theological sources and must political authority rest ultimately with an extraordinary sovereign authority? Obviously, these questions still haunt our world as we move further into the 21st century.” John P. McCormick, University of Chicago “Every student of Schmitt will need to probe his post-1945 writings and will be fascinated by this superb new translation which brings out Schmitt’s self-imposed continued wrestling, despite opposition, with the relation between the political and theological realms. The Introduction gives a full account of why this thoroughly disturbing thinker continues to mean so much to both Right and Left.” Jeremy Tambling, The University of Manchester "The importance of this text lies not simply in the arguments herein, important as they are, but especially as an additional means of situating some of the central concerns that continuously provoked Schmitt's writings." Polticial Studies ReviewTable of ContentsEditors’ Introduction. Notes on the Translation. Guideline for the reader. Introduction. I. The Myth of the Ultimate Theological Closure. 1. The Content of the Myth. 2. Hans Barion’s Critique of Political Theology. 3. The Contemporary Significance of the Myth of Closure. (Hans Maier – Ernst Feil – Ernst Topitsch). II. The Legendary Document. 1. The Genesis and the Historical limits of the Matter. 2. Politico-theological Interpolation: le roi règne il ne gouverne pas. 3. The Limits of the Matter and Question from the Political Side: Monarchy. 4. The Limits of the Matter and Question from the Theological Side: Monotheism. 5. Eusebius as the Prototype for Political Theology. 6. The Confrontation between Eusebius and Augustine. III. The Legendary Conclusion. 1. The Claims of the Conclusion. 2. The Assertive Power of the Conclusion. Postscript. On the Current Situation of the Problem: The Legitimacy of Modernity. Appendix: ‘Peterson’s conclusion and concluding footnote.’. Index

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Book SynopsisThe Holy Spirit wants those who know Him to hear when He speaks to their heart, soul, and spirit. He wants to help believers enter into the relationship with God they yearn for, the wholeness and freedom God has for them, and the fulfillment of God’s promises to them.Trade Review"The subject of the Holy Spirit is one that welcomes clear and straightforward treatment, and in this terrific work Stormie Omartian gives us both. People get so confused about the person of the Holy Spirit, the baptism of the Holy Spirit, the ministry of the Holy Spirit, and Stormie has provided a wonderful road map for that journey."Stormie is always a wise, firm and loving voice that speaks to us through these pages. She has lived these lessons—her life is a testimony to them. This book is another highly recommended addition to your library." —Katie Stewart"The subject of the Holy Spirit is one that welcomes clear and straightforward treatment, and in this terrific work Stormie Omartian gives us both. People get so confused about the person of the Holy Spirit, the baptism of the Holy Spirit, the ministry of the Holy Spirit, and Stormie has provided a wonderful road map for that journey."Stormie is always a wise, firm and loving voice that speaks to us through these pages. She has lived these lessons—her life is a testimony to them. This book is another highly recommended addition to your library." —Katie Stewart

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Book SynopsisThe Power of a Praying Parent Book of Prayers is a lovely gift that will draw your heart to the Lord in prayer. These prayers will give you confidence and peace in your parenting skills as you pray for God's best and most wonderful promises to come true in your children's lives.

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Book SynopsisThe Number One New York Times Bestseller! THE CONFIDENT WOMAN will enable you to live with purpose and fulfil your true potential

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Book SynopsisIS YOUR GOD TOO NICE? A timely and forthright book from one of the church's most trusted and loved teachers.

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Book SynopsisKNOWING GOD is one of the most significant and popular Christian books of our time and has deepened the faith and understanding of millions of people around the world.''Dr Packer says we''re cruel to ourselves if we try to live in his world without knowing about the God whose world it is and who runs it. I''m convinced we''re cruel if we deny ourselves the wisdom contained in this Christian classic.'' Rico TiceTrade Reviewa spiritual classic * John Stott *

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Book SynopsisAbraham Joshua Heschel was one of the most revered religious leaders of the 20th century, and God in Search of Man and its companion volume, Man Is Not Alone, two of his most important books, are classics of modern Jewish theology. God in Search of Man combines scholarship with lucidity, reverence, and compassion as Dr. Heschel discusses not man''s search for God but God''s for man--the notion of a Chosen People, an idea which, he writes, signifies not a quality inherent in the people but a relationship between the people and God. It is an extraordinary description of the nature of Biblical thought, and how that thought becomes faith.

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Book SynopsisFundamentals.- to Psychology, Religion, and Spirituality.- Science, Religion, and Psychology.- Religious Traditions.- DialoguePast, Present, and Future.- Phenomenological Approaches to Religion and Spirituality.- Psychodynamic and Relational Approaches.- Contemporary Approaches and Debates.- Human Development.- Fundamentals of Human Development, Religion, and Spirituality.- Religion and Development in Childhood and Adolescence.- Religion, Spirituality, and Development in Adulthood.- Applications.- Religion, Spirituality, and Physical Health.- Religion, Spirituality, and Mental Health.- Practices and Religious Communities.- Individual Religious and Spiritual Practices.- Helping Relationships: Counseling and Spiritual Growth.- Looking Back.Trade ReviewFrom the reviews: "James Nelson’s book … is explicitly offered in the tradition of dialogue. … The great strength of this book lies in the impressive array of topics it covers … . those interested in delving further into a particular topic will surely welcome this surfeit of citations … . Nelson’s postmodern and pluralistic perspective, and the final emphasis on practical applications will … make it attractive for potential adoption as a textbook in courses on psychology and religion, especially when a religion-friendly approach is desired." (David M. Wulff, PsycCRITIQUES, Vol. 54 (39), 2009) “The book … will be a valuable resource for graduate students taking courses in the psychology of religion. Counseling professionals, especially those in spiritual and pastoral counseling, theologians, and religious practitioners and others taking seminary courses will find this book to be beneficial and enlightening. … This book is alone in offering a rich, in-depth, and fascinating dialog among psychologists, theologians, and religious practitioners on the fundamental questions of human existence and our place in the world. … will serve academics and counseling practitioners well.” (Michael S. Goldsby, Doody’s Review Service, January, 2010)Table of ContentsI. Fundamentals. 1. Introduction to Psychology, Religion & Spirituality. 1.1. Introduction. 1.2. Basic Concepts: Religion and Spirituality. 1.3. Religion and Spirituality Today. 1.4. Psychological Approaches to Religion and Spirituality. 1.5. Religious and Theological Responses. 1.6. Current Research and Approaches. 1.7. Conclusion and a Look Ahead. 2. Science, Religion and Psychology. 2.1. Philosophical Concepts and Issues. 2.2. Early Modern Views of Science and Religion. 2.3. The Rise of Classical Positivism. 2.4. Logical Positivism. 2.5. Contemporary Issues in Science and Religion. 2.6. Conclusion. 3. Religious Traditions. 3.1. Hinduism. 3.2. Buddhism. 3.3. Christianity. 3.4. Conclusion. II. Dialogue—Past, Present, and Future. 4. Phenomenological Approaches. 4.1. Introduction. 4.2. William James. 4.3. Perennial and Universalist Views. 4.4. Constructivism and Responses. 4.5. Conversion. 4.6. Religious Perspectives. 4.7. Conclusion. 5. Psychodynamic and Relational Approaches. 5.1. Freud: Master of Suspicion. 5.2. Jung and Archetypal Religion. 5.3. Erik Ericson. 5.4. Object Relations Approaches. 5.5. Conclusion. 6. Contemporary Approaches and Debates. 6.1. Neurobiological Approaches to Religion. 6.2. Evolutionary Psychology and Religion. 6.3. Postmodern Perspectives, Psychology, and Religion. 6.4. Conclusion. III. Human Development. 7. Fundamentals of Human Development, Religion and Spirituality. 7.1. Basic Issues in Developmental Therapy. 7.2. Religious Models of Spiritual Development. 7.3. Early Genetic Theories of Religious Development. 7.4. Cognitive-Structuralist Theories of Development. 7.5. Integrative Approaches to Religious Development. 7.6. Conclusion. 8. Religion and Development in Childhood and Adolescence. 8.1. Religion and Religious Socialization in Childhood. 8.2. Attachment and Religion in Children and Adults. 8.3. God Image and Representation. 8.4. Adolescent Description. 8.5. Identity, Development,Gender and Religion. 8.6. Conclusion. 9. Religion, Spirituality and Development in Adulthood. 9.1. Issues in Adult Development Research. 9.2. Young Adult and Midlife Development. 9.3. Mechanisms of Stability and Change. 9.4. Religion and Spirituality in Older Adult. 9.5. Conclusion. IV. Application. 10. Religion, Spirituality and Physical Health. 10.1. Scientific Approaches to Religion and Health. 10.2. Religion, Health, and Coping. 10.3. Religious Perspectives on Health. 10.4. Collaborative Approaches to Health. 10.5. Conclusion. 11. Religion, Spirituality and Mental Health. 11.1. Psychological Models of Mental Health. 11.2. Spiritual and Religious Models of Mental Health. 11.3. Psychological and Spiritual Views of Specific Problems. 11.4. Religion and Spirituality in Mental Health Treatment. 11.5. Conclusion. 12. Practices and Religious Communities. 12.1. Religious and Spiritual Practices in Community. 12.2. Religious Self-understandings of Community. 12.3. Psychological Perspectives on Religious Communities. 12.4. Religious Practices in Community. 12.5. Problems of Religious Communities. 12.6. Conclusion. 13. Individual Religious and Spiritual Practices. 13.1. Religious and Spiritual Practices: Prayer and Meditation. 13.2. Early Christian and Orthodox Prayer and Ascetic Practice. 13.3. Prayer and the Western Contemplative Tradition. 13.4. Christian Protestant and Modern Views of Prayer. 13.5. Meditation: Eastern Perspectives. 13.6. Meditation: Psychological Perspectives. 13.7. Conclusion. 14. Helping Relationships: Counseling and Spiritual Growth. 14.1. Religious Approaches to Guidance and Helping. 14.2. Spiritual and Religious Issues in Psychotherapy. 14.3. New Religious Approaches to Psychotherapy. 14.4. Conclusion. 15. Looking Back. 15.1: Lessons from Dialogue. 15.2: Approaches to Dialogue. 15.3: Barriers to Dialogue. 15.4: Prospects and Directions for Dialogue.

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Book SynopsisA shocking look at the ways governments and organisations track and control us and the ways we can fight back.Trade Review"In "Data and Goliath" Bruce Schneier, a computer-security expert, does a fine job of laying out the problems caused by this compulsive collection of personal data...Some recent books on digital privacy have been written by journalists, with an emphasis on sugary narrative instead of original analysis. This one comes from a practitioner, and offers a deep but accessible look at surveillance in the post-Snowden, big-data era." -- The Economist"Bruce Schneier...grasps this revolution's true dimensions...Schneier paints a picture of the big-data revolution that is dark, but compelling; one in which the conveniences of our digitized world have devalued privacy." -- Nature"He [Schneier] is passionate about the subject—and he shows exactly why and how it matters. The combination of qualitative analysis and detailed examples is compelling and the conclusions are stark. Surveillance matters, and not just at a theoretical level. Schneier shows how it causes damage even when it's used "properly", and also offers examples of how it can be and is abused. And he is at his best when demolishing the case for mass surveillance from a security perspective: it's here that his expertise really kicks in. His understanding of encryption, cyberattacks and vulnerabilities, and his ability to explain them in a relatively accessible way, is impressive and admirable." -- Times Higher Education"...excellent new book…" -- The Observer"...important book..." -- New Internationalist

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Book SynopsisThe Word Biblical Commentary delivers the best in biblical scholarship, from the leading scholars of our day who share a commitment to Scripture as divine revelation. This series emphasizes a thorough analysis of textual, linguistic, structural, and theological evidence. The result is judicious and balanced insight into the meanings of the text in the framework of biblical theology. These widely acclaimed commentaries serve as exceptional resources for the professional theologian and instructor, the seminary or university student, the working minister, and everyone concerned with building theological understanding from a solid base of biblical scholarship.Overview of Commentary Organization Introduction—covers issues pertaining to the whole book, including context, date, authorship, composition, interpretive issues, purpose, and theology. Each section of the commentary includes: Pericope Bibliography—a helpful resource containing the mos

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Book SynopsisPublisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality,  authenticity, or access to any online entitlements included with the product.Bridge the gap between basic and clinical science with this authoritative guide to neuroscienceCreated by an expert team of neuroscience educators, this comprehensive guide delivers the knowledge and insight you need to build your understanding of neuroscienceâquickly and easily. Divided into two parts, the guide offers a thorough treatment of the basic science of the anatomy and function of the nervous system, as well an extended treatment of nervous system disorders and therapeutics.Packed with 500 color illustrations, Essentials of Modern Neuroscience provides both clinical content and numerous cases in an engaging, simple-to-understand style. It includes the strong pedagogy that makes LANGE basic science titles so popular and pTable of ContentsTABLE OF CONTENTSPart I: Cellular Neuroscience1. Neurohistology2. Origin of the membrane potential3. Action potential4. Single ion channels and gating mechanisms5. Ion channel structure-function6. Ion channel diversity and regulation7. Ion channel diseases8. Fundamentals of synaptic transmission9. Synaptic plasticity10. Neurotransmitter release11. Neurotransmitter reuptakePart II: Molecular & Developmental Neuroscience1. Axon guidance2. Synapse formation3. Dendrite formation4. Gliogenesis5. Corticogenesis6. Neuronal migration7. Neurogenesis and neuronal stem cellsPart III: Sensory & Systems Neuroscience1. Genes, circuits and behavior2. Human neurogenetics3. Visual systems4. Auditory systems5. Olfactory systems6. Motor systems7. Pain and somatosensory8. Learning9. Cognitive neuroscience10. Affective disorders

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Book SynopsisThe Me I Want to Be will help you discover spiritual vitality like never before as you learn to live in the flow of the spirit.Why does spiritual growth seem so difficult?God''s vision for your life is not just that you are saved by grace, but that you also learn to live by grace, flourishing with the Spirit flowing through you. And this book will show how God''s perfect vision for you starts with a powerful promise: All those who trust in God will be like a tree planted by the water that sends out its roots by the stream. It does not fear when heat comes; its leaves are always green. It has no worries in a year of drought and never fails to bear fruit (Jeremiah 17:7-8).Pastor and bestselling author John Ortberg first helps gauge your spiritual health and measure the gap between where you are now and where God intends you to be. Then he provides detailed tasks and exercises to help you live in the flow of the Spirit, ci

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Book SynopsisProvides an introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based approach, this book reflects the advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body.Trade Review“Overall, it could be the basis of an excellent course for junior pharmacologists in basic science research who need a greater focus on the mechanisms of drug action rather than an encyclopedic survey of clinical drug use.” (Doody’s, 26 July 2013)Table of ContentsPreface ix Abbreviations x 1 Introduction to Drug Targets and Molecular Pharmacology 1 1.1 Introduction to molecular pharmacology 1 1.2 Scope of this textbook 2 1.3 The nature of drug targets 3 1.4 Future drug targets 7 1.5 Molecular pharmacology and drug discovery 11 References 12 2 Molecular Cloning of Drug Targets 13 2.1 Introduction to molecular cloning – from DNA to drug discovery 13 2.2 ‘Traditional’ pharmacology 14 2.3 The relevance of recombinant DNA technology to pharmacology/drug discovery 14 2.4 The ‘cloning’ of drug targets 15 2.5 What information can DNA cloning provide? 20 2.6 Comparing the pharmacologic profile of the ‘cloned’ and the ‘native’ drug target 23 2.7 Reverse pharmacology illustrated on orphan GPCRs 24 2.8 Summary 27 References 27 3 G Protein-coupled Receptors 31 3.1 Introduction to G protein-coupled receptors 31 3.2 Heterotrimeric G-proteins 36 3.3 Signal transduction pathways 40 3.4 Desensitisation and down-regulation of GPCR signalling 44 3.5 Constitutive GPCR activity 45 3.6 Promiscuous G-protein coupling 47 3.7 Agonist-directed signalling 48 3.8 Allosteric modulators of GPCR function 49 3.9 Pharmacological chaperones for GPCRs 50 3.10 GPCR dimerisation 51 3.11 GPCR splice variants 63 3.12 Summary 67 References 67 Useful Web sites 70 4 Ion Channels 71 4.1 Introduction 71 4.2 Voltage-gated ion channels 73 4.3 Other types of voltage-gated ion channels 89 4.4 Ligand-gated ion channels 109 4.5 Summary 125 References 125 5 Transporter Proteins 129 5.1 Introduction 129 5.2 Classification 129 5.3 Structural analysis of transporters 132 5.4 Transporter families of pharmacological interest 133 5.5 Transporters and cellular homeostasis 167 5.6 Summary 169 References 169 6 Cystic Fibrosis: Alternative Approaches to the Treatment of a Genetic Disease 175 6.1 Introduction 175 6.2 Cystic fibrosis transmembrane conductance regulator 179 6.3 Mutations in CFTR 183 6.4 Why is cystic fibrosis so common? 184 6.5 Animal models of Cystic fibrosis 186 6.6 Pharmacotherapy 186 6.7 Gene therapy 191 6.8 Conclusion 195 References 196 7 Pharmacogenomics 201 7.1 Types of genetic variation in the human genome 201 7.2 Thiopurine S-methyltransferase and K+ channel polymorphisms 202 7.3 Polymorphisms affecting drug metabolism 204 7.4 Methods for detecting genetic polymorphisms 209 7.5 Genetic variation in drug transporters 211 7.6 Genetic variation in G protein coupled receptors 215 7.7 Summary 225 References 225 Useful Web sites 226 8 Transcription Factors and Gene Expression 227 8.1 Control of gene expression 227 8.2 Transcription factors 229 8.3 CREB 233 8.4 Nuclear receptors 238 8.5 Peroxisome proliferator-activated receptors 240 8.6 Growth factors 247 8.7 Alternative splicing 247 8.8 RNA editing 251 8.9 The importance of non-coding RNAs in gene expression 257 8.10 Summary 270 References 271 9 Cellular Calcium 277 9.1 Introduction 277 9.2 Measurement of calcium 278 9.3 The exocrine pancreas 289 9.4 Calcium signalling in pancreatic acinar cells 292 9.5 Nuclear calcium signalling 303 9.6 Conclusions 310 References 311 10 Genetic Engineering of Mice 315 10.1 Introduction to genetic engineering 315 10.2 Genomics and the accumulation of sequence data 315 10.3 The mouse as a model organism 318 10.4 Techniques for genetic engineering 319 10.5 Examples of genetically-engineered mice 332 10.6 Summary 334 References 334 11 Signalling Complexes: Protein-protein Interactions and Lipid Rafts 339 11.1 Introduction to cell signalling complexes 339 11.2 Introduction to GPCR interacting proteins 340 11.3 Methods used to identify GPCR interacting proteins 340 11.4 Functional roles of GPCR interacting proteins 345 11.5 GPCR signalling complexes 348 11.6 GPCR and ion channel complexes 355 11.7 Ion channel signalling complexes 356 11.8 Development of pharmaceuticals that target GPCR interacting proteins 356 11.9 Development of pharmaceuticals that target protein-protein interactions 356 11.10 Lipid rafts 357 11.11 Receptor-mediated endocytosis 361 11.12 Summary 364 References 364 12 Recombinant Proteins and Immunotherapeutics 367 12.1 Introduction to immunotherapeutics 367 12.2 Historical background of immunotherapeutics 368 12.3 Basis of immunotherapeutics 368 12.4 Types of immunotherapeutics 369 12.5 Humanisation of antibody therapy 372 12.6 Immunotherapeutics in clinical practice 376 12.7 Advantages and disadvantages of immunotherapy 378 12.8 The future 379 12.9 Summary 380 References 380 Glossary 381 Index 403

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Book SynopsisExperts estimate that as many as 98,000 people die in any given year from medical errors that occur in hospitals. That's more than die from motor vehicle accidents, breast cancer, or AIDSthree causes that receive far more public attention. Indeed, more people die annually from medication errors than from workplace injuries. Add the financial cost to the human tragedy, and medical error easily rises to the top ranks of urgent, widespread public problems. To Err Is Human breaks the silence that has surrounded medical errors and their consequencebut not by pointing fingers at caring health care professionals who make honest mistakes. After all, to err is human. Instead, this book sets forth a national agendawith state and local implicationsfor reducing medical errors and improving patient safety through the design of a safer health system. This volume reveals the often startling statistics of medical error and the disparity between the incidence of error and public perception of it, g

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Book SynopsisWinner of the 2011 International Society for the Study of Trauma and Dissociation (ISSTD) Pierre Janet Writing Award. A patient-oriented manual for complex trauma survivors.Trade Review"[A] book worthy of [therapists’] time." -- PsychCentral"This book is a much-welcomed tool for working with individuals with complex trauma. Although there are other training manuals that address the treatment of trauma, there is none that deal specifically with the subset of dissociative pathology. This manual is the first of its kind, a hands-on and practical training and skill-building tool for individuals and therapists. . . . The book has a user-friendly approach that is integrative and eclectic and can easily be introduced and incorporated in ongoing treatment. . . . For therapist and clients, navigating complex trauma can feel daunting and confusing with many stops and falls that may leave both feeling discouraged. This book is an anchor for the work, a place to return when uncertainty invades treatment." -- Social Work with Groups"Coping with Trauma-Related Dissociation contains the lucid explanations, practical skills, and collective wisdom of three therapists with decades of experience treating dissociative patients. This book serves as a manual for therapists, a guide for trainers, and a workbook for dissociative disorder patients, delivering an up-to-date blend of the best clinical practices with recent advances in mindfulness therapy and cognitive behavioral approaches to pathological dissociation." -- Frank W. Putnam, MD, Professor of Pediatrics and Psychiatry, University of Cincinnati College of Medicine"This book is a welcome and much-needed resource for complex dissociative clients and their therapists. It offers a myriad of exercises and strategies to help clients challenge dissociative adaptations and replace them with other means of coping, so that they can develop a more integrated self and life, and ultimately regain control of their bodies and minds." -- Christine A. Courtois, PhD, ABPP, author of Healing the Incest Wound: Adult Survivors in Therapy and Recollections of Sexual Abuse

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Book SynopsisThis book demonstrates how qualitative methods can be used to address research issues pertinent to mental health practice and psychotherapy. With contributions from leading researchers, the book examines how to review and appraise existing qualitative literature, how to choose the most appropriate method, and how to approach ethical issues.Trade Review“In a field that at times feels dominated by obfuscating jargon and a cult-like zeal, the editors have produced an accessible, illuminating text that will be of great value to those wishing to gain an introduction to this essential and developing area of mental health research.” (The British Journal of Psychiatry, 1 May 2012) "David Harper and Andrew Thompson’s book Qualitative Research Methods in Mental Health and Psychotherapy provides a reference for students and practitioners who are using qualitative research to explore topics related to mental health. The book provides a rich and comprehensive text, with contributions from specialized authors on a number of key themes and research methods relevant to qualitative research. Despite being specifically aimed at those researching mental health issues, this text would be useful for any student or practitioner who wishes to get to grips with ‘big q research’..." (Feminism and Psychology, 2013) “Since receiving this book for review, I have found myself repeatedly recommending it to fellow doctoral researchers from a range of professional backgrounds, at all stages of candidature. I do so because, in my opinion, this book addresses, in an accessible, clear, yet thorough manner, the issues which all students and practitioner-researchers face in aspiring to produce high quality, creative, qualitative research in mental health and psychotherapy.” (QMiP Bulletin Issue 15, Spring 2013) Table of ContentsAbout the Contributors. Acknowledgements. PART I Getting Started. 1 Introduction (Andrew R. Thompson and David Harper). 2 Identifying and Synthesizing Qualitative Literature (Rachel L. Shaw). 3 Ethical Issues in Qualitative Mental Health Research (Andrew R. Thompson and Eleni Chambers). 4 Participation and Service User Involvement (Alison Faulkner). 5 Qualitative Data Collection: Asking the Right Questions (Hannah Frith and Kate Gleeson). 6 Qualitative Methods for Studying Psychotherapy Change Processes (Robert Elliott). 7 Choosing a Qualitative Research Method (David Harper). PART II Methods. 8 Interpretative Phenomenological Analysis in Mental Health and Psychotherapy Research (Michael Larkin and Andrew R. Thompson). 9 Existentialist-Informed Hermeneutic Phenomenology (Carla Willig and Abigail Billin). 10 Grounded Theory Methods for Mental Health Practitioners (Alison Tweed and Kathy Charmaz). 11 Discourse Analysis (Eugenie Georgaca and Evrinomy Avdi). 12 Narrative Psychology (Michael Murray and Sally Sargeant). 13 Ethnomethodology/Conversation Analysis (Mark Rapley). 14 Q Methodological Research in Mental Health and Psychotherapy (Wendy Stainton Rogers and Phillip O. Dyson). 15 Thematic Analysis (Helene Joffe). PART III Establishing Good Quality Qualitative Research in Mental Health. 16 In Pursuit of Quality (Liz Spencer and Jane Ritchie). 17 Emerging Issues and Future Directions (David Harper and Andrew R. Thompson). Index.

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Book SynopsisAs Bowlby himself points out in his introduction to this seminal childcare book, to be a successful parent means a lot of very hard work. Giving time and attention to children means sacrificing other interests and activities, but for many people today these are unwelcome truths. Bowlbyâs work showed that the early interactions between infant and caregiver have a profound impact on an infant's social, emotional, and intellectual growth. Controversial yet powerfully influential to this day, this classic collection of Bowlbyâs lectures offers important guidelines for child rearing based on the crucial role of early relationships.Trade Review'One of the most influential forces in child psychiatry and psychology, Dr. Bowlby challenged basic tenets of psychoanalysis and pioneered methods of investigating the emotional life of children.' - The New York TimesTable of ContentsHolmes, Preface to the Routledge Classics Edition. Preface. Caring for Children. The Origins of Attachment Theory. Psychoanalysis as Art and Science. Psychoanalysis as a Natural Science. Violence in the Family. On Knowing What You Are Not Supposed To Know and Feeling What You Are Not Supposed To Feel. The Role of Attachment in Personality and Development. Attachment, Communication, and the Therapeutic Process.

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Book SynopsisPaine''s years of study and reflection on the role of religion in society culminated with this, his final work. An attack on revealed religion from the deist point of view embodied by Paine''s credo, I believe in one God, and no more its critical and objective examination of Old and New Testaments cites numerous contradictions.

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Book SynopsisThis book is one of the first to give an overview of biomechatronic exoskeletons including their applications and implications. A collective reference specifically on biomechatronic exoskeletons, an area that is relevant to mechanical and biomedical engineers as well as those working in prosthetics, rehabilitation, and defense.Table of ContentsForeword xv Preface xvii List of Contributors xix 1 Introduction to wearable robotics 1J. L. Pons, R. Ceres and L. Calderón 1.1 Wearable robots and exoskeletons 1 1.1.1 Dual human–robot interaction in wearable robotics 3 1.1.2 A historical note 4 1.1.3 Exoskeletons: an instance of wearable robots 5 1.2 The role of bioinspiration and biomechatronics in wearable robots 6 1.2.1 Bioinspiration in the design of biomechatronic wearable robots 8 1.2.2 Biomechatronic systems in close interaction with biological systems 9 1.2.3 Biologically inspired design and optimization procedures 9 1.3 Technologies involved in robotic exoskeletons 9 1.4 A classification of wearable exoskeletons: application domains 10 1.5 Scope of the book 12 References 15 2 Basis for bioinspiration and biomimetism in wearable robots 17A. Forner-Cordero, J. L. Pons and M. Wisse 2.1 Introduction 17 2.2 General principles in biological design 18 2.2.1 Optimization of objective functions: energy consumption 19 2.2.2 Multifunctionality and adaptability 21 2.2.3 Evolution 22 2.3 Development of biologically inspired designs 23 2.3.1 Biological models 24 2.3.2 Neuromotor control structures and mechanisms as models 24 2.3.3 Muscular physiology as a model 27 2.3.4 Sensorimotor mechanisms as a model 29 2.3.5 Biomechanics of human limbs as a model 31 2.3.6 Recursive interaction: engineering models explain biological systems 31 2.4 Levels of biological inspiration in engineering design 31 2.4.1 Biomimetism: replication of observable behaviour and structures 32 2.4.2 Bioimitation: replication of dynamics and control structures 32 2.5 Case Study: limit-cycle biped walking robots to imitate human gait and to inspire the design of wearable exoskeletons 33M. Wisse 2.5.1 Introduction 33 2.5.2 Why is human walking efficient and stable? 33 2.5.3 Robot solutions for efficiency and stability 34 2.5.4 Conclusion 36 Acknowledgements 36 2.6 Case Study: MANUS-HAND, mimicking neuromotor control of grasping 36J. L. Pons, R. Ceres and L. Calderón 2.6.1 Introduction 37 2.6.2 Design of the prosthesis 37 2.6.3 MANUS-HAND control architecture 39 2.7 Case Study: internal models, CPGs and reflexes to control bipedal walking robots and exoskeletons: the ESBiRRo project 40A. Forner-Cordero 2.7.1 Introduction 40 2.7.2 Motivation for the design of LC bipeds and current limitations 41 2.7.3 Biomimetic control for an LC biped walking robot 41 2.7.4 Conclusions and future developments 43 References 43 3 Kinematics and dynamics of wearable robots 47A. Forner-Cordero, J. L. Pons, E. A. Turowska and A. Schiele 3.1 Introduction 47 3.2 Robot mechanics: motion equations 48 3.2.1 Kinematic analysis 48 3.2.2 Dynamic analysis 53 3.3 Human biomechanics 57 3.3.1 Medical description of human movements 57 3.3.2 Arm kinematics 59 3.3.3 Leg kinematics 61 3.3.4 Kinematic models of the limbs 64 3.3.5 Dynamic modelling of the human limbs 68 3.4 Kinematic redundancy in exoskeleton systems 70 3.4.1 Introduction to kinematic redundancies 70 3.4.2 Redundancies in human–exoskeleton systems 71 3.5 Case Study: a biomimetic, kinematically compliant knee joint modelled by a four-bar linkage 74J. M. Baydal-Bertomeu, D. Garrido and F. Moll 3.5.1 Introduction 74 3.5.2 Kinematics of the knee 75 3.5.3 Kinematic analysis of a four-bar linkage mechanism 75 3.5.4 Genetic algorithm methodology 77 3.5.5 Final design 77 3.5.6 Mobility analysis of the optimal crossed four-bar linkage 78 3.6 Case Study: design of a forearm pronation–supination joint in an upper limb exoskeleton 79J. M. Belda-Lois, R. Poveda, R. Barberà and J. M. Baydal-Bertomeu 3.6.1 The mechanics of pronation–supination control 79 3.7 Case Study: study of tremor characteristics based on a biomechanical model of the upper limb 80E. Rocon and J. L. Pons 3.7.1 Biomechanical model of the upper arm 81 3.7.2 Results 83 References 83 4 Human–robot cognitive interaction 87L. Bueno, F. Brunetti, A. Frizera and J. L. Pons 4.1 Introduction to human–robot interaction 87 4.2 cHRI using bioelectrical monitoring of brain activity 89 4.2.1 Physiology of brain activity 90 4.2.2 Electroencephalography (EEG) models and parameters 92 4.2.3 Brain-controlled interfaces: approaches and algorithms 93 4.3 cHRI through bioelectrical monitoring of muscle activity (EMG) 96 4.3.1 Physiology of muscle activity 97 4.3.2 Electromyography models and parameters 98 4.3.3 Surface EMG signal feature extraction 99 4.3.4 Classification of EMG activity 102 4.3.5 Force and torque estimation 104 4.4 cHRI through biomechanical monitoring 104 4.4.1 Biomechanical models and parameters 105 4.4.2 Biomechanically controlled interfaces: approaches and algorithms 108 4.5 Case Study: lower limb exoskeleton control based on learned gait patterns 109J. C. Moreno and J. L. Pons 4.5.1 Gait patterns with knee joint impedance modulation 109 4.5.2 Architecture 109 4.5.3 Fuzzy inference system 110 4.5.4 Simulation 110 4.6 Case Study: identification and tracking of involuntary human motion based on biomechanical data 111E. Rocon and J. L. Pons 4.7 Case Study: cortical control of neuroprosthetic devices 115J. M. Carmena 4.8 Case Study: gesture and posture recognition using WSNs 118E. Farella and L. Benini 4.8.1 Platform description 119 4.8.2 Implementation of concepts and algorithm 119 4.8.3 Posture detection results 121 4.8.4 Challenges: wireless sensor networks for motion tracking 121 4.8.5 Summary and outlook 122 References 122 5 Human–robot physical interaction 127E. Rocon, A. F. Ruiz, R. Raya, A. Schiele and J. L. Pons 5.1 Introduction 127 5.1.1 Physiological factors 128 5.1.2 Aspects of wearable robot design 129 5.2 Kinematic compatibility between human limbs and wearable robots 130 5.2.1 Causes of kinematic incompatibility and their negative effects 130 5.2.2 Overcoming kinematic incompatibility 133 5.3 Application of load to humans 134 5.3.1 Human tolerance of pressure 134 5.3.2 Transmission of forces through soft tissues 135 5.3.3 Support design 138 5.4 Control of human–robot interaction 138 5.4.1 Human–robot interaction: human behaviour 139 5.4.2 Human–robot interaction: robot behaviour 140 5.4.3 Human–robot closed loop 143 5.4.4 Physically triggered cognitive interactions 146 5.4.5 Stability 147 5.5 Case Study: quantification of constraint displacements and interaction forces in nonergonomic pHR interfaces 149A. Schiele 5.5.1 Theoretical analysis of constraint displacements, d 150 5.5.2 Experimental quantification of interaction force, Fd 151 5.6 Case Study: analysis of pressure distribution and tolerance areas for wearable robots 154J. M. Belda-Lois, R. Poveda and M. J. Vivas 5.6.1 Measurement of pressure tolerance 155 5.7 Case Study: upper limb tremor suppression through impedance control 156E. Rocon and J. L. Pons 5.8 Case Study: stance stabilization during gait through impedance control 158J. C. Moreno and J. L. Pons 5.8.1 Knee–ankle–foot orthosis (exoskeleton) 159 5.8.2 Lower leg–exoskeleton system 159 5.8.3 Stance phase stabilization: patient test 160 References 161 6 Wearable robot technologies 165J. C. Moreno, L. Bueno and J. L. Pons 6.1 Introduction to wearable robot technologies 165 6.2 Sensor technologies 166 6.2.1 Position and motion sensing: HR limb kinematic information 166 6.2.2 Bioelectrical activity sensors 171 6.2.3 HR interface force and pressure: human comfort and limb kinetic information 175 6.2.4 Microclimate sensing 179 6.3 Actuator technologies 181 6.3.1 State of the art 181 6.3.2 Control requirements for actuator technologies 183 6.3.3 Emerging actuator technologies 185 6.4 Portable energy storage technologies 189 6.4.1 Future trends 189 6.5 Case Study: inertial sensor fusion for limb orientation 190J. C. Moreno, L. Bueno and J. L. Pons 6.6 Case Study: microclimate sensing in wearable devices 192J. M. Baydal-Bertomeu, J. M. Belda-Lois, J. M. Prat and R. Barberà 6.6.1 Introduction 192 6.6.2 Thermal balance of humans 192 6.6.3 Climate conditions in clothing and wearable devices 193 6.6.4 Measurement of thermal comfort 194 6.7 Case Study: biomimetic design of a controllable knee actuator 194J. C. Moreno, L. Bueno and J. L. Pons 6.7.1 Quadriceps weakness 195 6.7.2 Functional analysis of gait as inspiration 195 6.7.3 Actuator prototype 197 References 198 7 Communication networks for wearable robots 201F. Brunetti and J. L. Pons 7.1 Introduction 201 7.2 Wearable robotic networks, from wired to wireless 203 7.2.1 Requirements 203 7.2.2 Network components: configuration of a wearable robotic network 205 7.2.3 Topology 206 7.2.4 Wearable robatic network goals and profiles 208 7.3 Wired wearable robotic networks 209 7.3.1 Enabling technologies 209 7.3.2 Network establishment, maintenance, QoS and robustness 213 7.4 Wireless wearable robotic networks 214 7.4.1 Enabling technologies 214 7.4.2 Wireless sensor network platforms 216 7.5 Case Study: smart textiles to measure comfort and performance 218J. Vanhala 7.5.1 Introduction 218 7.5.2 Application description 220 7.5.3 Platform description 221 7.5.4 Implementation of concepts 222 7.5.5 Results 222 7.5.6 Discussion 223 7.6 Case Study: ExoNET 224F. Brunetti and J. L. Pons 7.6.1 Application description 224 7.6.2 Network structure 224 7.6.3 Network components 224 7.6.4 Network protocol 225 7.7 Case Study: NeuroLab, a multimodal networked exoskeleton for neuromotor and biomechanical research 226A. F. Ruiz and J. L. Pons 7.7.1 Application description 226 7.7.2 Platform description 227 7.7.3 Implementation of concepts and algorithms 227 7.8 Case Study: communication technologies for the integration of robotic systems and sensor networks at home: helping elderly people 229J. V. Martí, R. Marín, J. Fernández, M. Nuñez, O. Rajadell, L. Nomdedeu, J. Sales, P. Agustí, A. Fabregat and A. P. del Pobil 7.8.1 Introduction 230 7.8.2 Communication systems 230 7.8.3 IP-based protocols 232 Acknowledgements 233 References 233 8 Wearable upper limb robots 235E. Rocon, A. F. Ruiz and J. L. Pons 8.1 Case Study: the wearable orthosis for tremor assessment and suppression (WOTAS) 236E. Rocon and J. L. Pons 8.1.1 Introduction 236 8.1.2 Wearable orthosis for tremor assessment and suppression (WOTAS) 236 8.1.3 Experimental protocol 239 8.1.4 Results 240 8.1.5 Discussion and conclusions 241 8.2 Case Study: the CyberHand 242L. Beccai, S. Micera, C. Cipriani, J. Carpaneto and M. C. Carrozza 8.2.1 Introduction 242 8.2.2 The multi-DoF bioinspired hand prosthesis 242 8.2.3 The neural interface 245 8.2.4 Conclusions 247 8.3 Case Study: the ergonomic EXARM exoskeleton 248A. Schiele 8.3.1 Introduction 248 8.3.2 Ergonomic exoskeleton: challenges and innovation 250 8.3.3 The EXARM implementation 251 8.3.4 Summary and conclusion 254 8.4 Case Study: the NEUROBOTICS exoskeleton (NEUROExos) 255S. Roccella, E. Cattin, N. Vitiello, F. Vecchi and M. C. Carrozza 8.4.1 Exoskeleton control approach 257 8.4.2 Application domains for the NEUROExos exoskeleton 258 8.5 Case Study: an upper limb powered exoskeleton 259J. C. Perry and J. Rosen 8.5.1 Exoskeleton design 259 8.5.2 Conclusions and discussion 268 8.6 Case Study: soft exoskeleton for use in physiotherapy and training 269N. G. Tsagarakis, D. G. Caldwell and S. Kousidou 8.6.1 Soft arm–exoskeleton design 270 8.6.2 System control 272 8.6.3 Experimental results 275 8.6.4 Conclusions 277 References 278 9 Wearable lower limb and full-body robots 283J. Moreno, E. Turowska and J. L. Pons 9.1 Case Study: GAIT–ESBiRRo: lower limb exoskeletons for functional compensation of pathological gait 283J. C. Moreno and J. L. Pons 9.1.1 Introduction 283 9.1.2 Pathological gait and biomechanical aspects 284 9.1.3 The GAIT concept 285 9.1.4 Actuation 286 9.1.5 Sensor system 286 9.1.6 Control system 286 9.1.7 Evaluation 287 9.1.8 Next generation of lower limb exoskeletons: the ESBiRRo project 289 9.2 Case Study: an ankle–foot orthosis powered by artificial pneumatic muscles 289D. P. Ferris 9.2.1 Introduction 289 9.2.2 Orthosis construction 290 9.2.3 Artificial pneumatic muscles 291 9.2.4 Muscle mounting 291 9.2.5 Orthosis mass 292 9.2.6 Orthosis control 292 9.2.7 Performance data 292 9.2.8 Major conclusions 295 9.3 Case Study: intelligent and powered leg prosthesis 295K. De Roy 9.3.1 Introduction 296 9.3.2 Functional analysis of the prosthetic leg 297 9.3.3 Conclusions 303 9.4 Case Study: the control method of the HAL (hybrid assistive limb) for a swinging motion 304J. Moreno, E. Turouska and J. L. Pons 9.4.1 System 305 9.4.2 Actuator control 305 9.4.3 Performance 306 9.5 Case Study: Kanagawa Institute of Technology power-assist suit 308K. Yamamoto 9.5.1 The basic design concepts 308 9.5.2 Power-assist suit 308 9.5.3 Controller 310 9.5.4 Physical dynamics model 310 9.5.5 Muscle hardness sensor 310 9.5.6 Direct drive pneumatic actuators 311 9.5.7 Units 311 9.5.8 Operating characteristics of units 312 9.6 Case Study: EEG-based cHRI of a robotic wheelchair 314T. F. Bastos-Filho, M. Sarcinelli-Filho, A. Ferreira, W. C. Celeste, R. L. Silva, V. R. Martins, D. C. Cavalieri, P. N. S. Filgueira and I. B. Arantes 9.6.1 EEG acquisition and processing 315 9.6.2 The PDA-based graphic interface 317 9.6.3 Experiments 317 9.6.4 Results and concluding remarks 318 Acknowledgements 319 References 319 10 Summary, conclusions and outlook 323J. L. Pons, R. Ceres and L. Calderón 10.1 Summary 323 10.1.1 Bioinspiration in designing wearable robots 324 10.1.2 Mechanics of wearable robots 326 10.1.3 Cognitive and physical human–robot interaction 327 10.1.4 Technologies for wearable robots 328 10.1.5 Outstanding research projects on wearable robots 329 10.2 Conclusions and outlook 330 References 332 Index 335

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Book SynopsisThe Book of Common Prayer is the old and well-loved prayer book of the Church of England, in use since the 16th century. It has also become one of the classic English texts, its prayers and expressions helping to mould the English language into what it is today. Cambridge''s new editions of the Prayer Book have been freshly typeset for the 21st century, using a modern digital typeface to give a clear printing image and greater readability. Nevertheless the format and page layout of this book follow the earlier Large-Print Edition Prayer Book page for page. It provides the complete 1662 services including the traditional forms of the baptism and marriage services. The prayer book comes in a burgundy imitation leather hardback binding and will be helpful for anyone needing slightly larger print for ease of reading.

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Book SynopsisFrom a bestselling author, an incendiary and uproarious assault on the pretensions of scientific atheists (National Review)Militant atheism is on the rise. Prominent thinkers including Richard Dawkins, Sam Harris, Daniel Dennett, and Christopher Hitchens have published best-selling books denigrating religious belief. And these authors are merely the leading edge of a larger movement that includes much of the scientific community. In response, mathematician David Berlinski, himself a secular Jew, delivers a biting defense of religious thought. The Devil''s Delusion is a brilliant, incisive, and funny book that explores the limits of science and the pretensions of those who insist it is the ultimate touchstone for understanding our world.

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Book SynopsisMany want a simple life, but find it difficult to actually live that way. They fight a constant battle to balance work, family, friends, and other demands on schedules stretched too thin. Joyce Meyer breaks it down to the simple principle of exercising faith rather than doubt and confidence rather than people-pleasing. She writes from her experience of struggling to balance work, family, friends, and all the other demands on limited time to show readers the simple answer to a simpler life.Joyce gives these and other practical and easy to implement ideas for finding real joy: Live to glorify God Let go of what lies behind Choose your battles Don''t be afraid of what people think Trust God to change other people Live with margin Don''t be so hard on yourself Stop doing things you don''t do well Remember that God is for you.Joyce reminds readers th

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Book SynopsisHow to understand the clients you have, not just their DSM checklists.

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Book Synopsis"An invaluable portrait of the evolution of international health in recent decades." —William Bynum, Wall Street JournalTrade Review"An invaluable portrait of the evolution of international health in recent decades…We need more people like Peter Piot who will rise to the occasion with spirit and passion." -- William Bynum - Wall Street Journal"[A] fascinating account of the complex behavioural responses that epidemics trigger among their human hosts." -- José Esparza - Nature"From laboratories to field epidemiology, boardrooms and political chambers, [No Time To Lose] charts an incredibly impactful career in science and the fine arts of diplomacy, communication and political engagement in difficult situations." -- Chikwe Ihekweazu - Nature"Insightful." -- Andrew Jack - Financial Times"A riveting read." -- Laurie Garrett - The Lancet"A timely and accessible memoir…enthralling reading…will appeal to budding young scientists." -- Booklist (starred review)"Piot helped assure that affordable drugs revolutionizing AIDS treatment would be available to the poorest victims. He leaves a legacy of change and hope in two worlds—medicine and politics—and an urgent reminder that their cooperation saves lives." -- Publishers Weekly (starred review)

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Book SynopsisProvides an account of the principles and practice of the basic techniques of plastic and reconstructive surgery that various surgeons should know. This title discusses the management, repair and reconstruction of defects and wounds using skin and other tissues and reviews potential problems and complications.Trade Review"Fundamental Techniques of Plastic Surgery remains one of our standard textbooks to be recommended to all trainees"British Journal of Plastic Surgery is no substitute. This text is concise, clear and well written. It is an excellent up to date source of information for all residents and plastic surgeons."Journal of the Royal College of Surgeons of Edinburgh chapters are certainly concise and describe each basic technique with precision and clarity. This helps to make the book easier to carry and this can be particularly useful reading for the trainee wherever they find themselves." "Overall, this book is incredibly useful for the Plastic Surgery trainee in helping them to develop the basic knowledge they will need to accompany the clinical experience they gain on the wards and in theatre."" Riaz Agha, Executive Editor, The Journal of Surgery; President, Guy's, King's and St Thomas' Surgical Society, July 2003 of current edition: "The chapters are certainly concise and describe each basic technique with precision and clarity. This helps to make the book easier to carry and this can be particularly useful reading for the trainee wherever they find themselves." "Overall, this book is incredibly useful for the Plastic Surgery trainee in helping them to develop the basic knowledge they will need to accompany the clinical experience they gain on the wards and in theatre."" Riaz Agha, Executive Editor, The Journal of Surgery; President, Guy's, King's and St Thomas' Surgical Society, July 2003Table of ContentsPART 1 BASIC TECHNIQUES 1. Wound management 2. The Z-plasty 3. Free skin grafts 4. Flaps 5. Additional techniques PART 2 SURGICAL APPLICATIONS 6. Hypertrophic scars and keloids 7. Radiation injury 8. Pressure sore management 9. Limb trauma 10. Neoplastic conditions 11. Hand surgery

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Book SynopsisThis book challenges the conventional security-based international policy frameworks that have developed for dealing with HIV/AIDS during and after conflicts, and examines first-hand evidence and experiences of conflict and HIV/AIDS.Since the turn of the century international policy agenda on security have focused on HIV/AIDS only as a concern for national and international security, ignoring people's particular experiences, vulnerabilities and needs in conflict and post-conflict contexts. Developing a gender-based framework for HIV/AIDS-conflict analysis, this book draws on research conducted in Burundi to understand the implications of post-conflict demobilization and reintegration policies on women and men and their vulnerability to HIV/AIDS. By centring the argument on personal reflections, this work provides a critical alternative method to engage with conflict and HIV/AIDS, and a much richer understanding of the relationship between the two.InteTable of ContentsIntroduction 1. Context, Conflict and Expereinces 2. Gender Relations 3. Gender Relations in the Conflict 4. Discontents of Re-integration 5. HIV/AIDS in People’s Lives 6. International Expert Knowledge and Its Production 7. People’s Voices 8. Communities of Policy and Communities of Everyday Life Conclusion

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Book SynopsisAn autobiography of a modern day mystic, an Irish woman with powers of the saints of old. It presents the testimony of a woman who sees things, beyond the range of our everyday experience.Trade ReviewThose who see angels are close to being angels. In this book, Lorna beautifully and graphically describes angels and how they workAngels in my Hair is more than just an autobiography. It is a revelation that will open your eyes and change your life. Angels in My Hair has a message that the world needs to hearLorna's wisdom and insights are breathtaking. This is a woman I have known for many years and admire enormously. She has made a big difference to my life and that of many othersIn times of universal deceit, never more so than now, the world needs guidance and hope. Angels in My Hair is an amazing book by an incredible woman, who shares her unique and fascinating experience of the guides at work with her in her own life and the messages they have for us allNobody is going to argue with her underlying message of love and compassion and forgiveness and her hopes for "peace among nations and peace in families". Spending time with her is both challenging and inspirational * The Irish Times *

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Book SynopsisThis print edition of The EACVI Textbook of Echocardiography comes with a DVD and access to the online version on Oxford Medicine Online, for as long as the edition is published by Oxford University Press. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge, and download all the figures and tables. This fully updated second edition of the official textbook of the European Association of Cardiovascular Imaging serves the educational requirements of cardiologists and all clinical medical professionals in echocardiography. It is fully-aligned with EACVI goals and reflects the core European syllabus. Published in partnership with the European Society of Cardiology and written by a team of expert authors, this textbook is a valuable resource on echocardiography and for accreditation through the EACVI. With its thorough and instructive text complemented by more than 500Trade Review"This will be a valuable resource for the study of clinical echocardiography. It will be of particular benefit to those individuals wishing to adhere to the curriculum endorsed by the European Association of Echocardiography." Doody's NotesTable of ContentsBASIC INSTRUMENTATION AND MODALITIES; CARDIAC MORPHOLOGY, HAEMODYNAMICS AND PHYSIOLOGY; DISEASE ECHOCARDIOGRAPHIC ASSESSMENT; DISEASE ECHOCARDIOGRAPHIC ASSESSMENT; SPECIFIC CLINICAL CONTEXT / ENVIRONMENT; MISCELLANEOUS

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Book SynopsisThe bestselling authors of the groundbreaking Artisan Bread in Five Minutes a Day bring you a cookbook with 90 delicious, entirely gluten-free bread recipes made from easy-to-find ingredients--a perfect gift for health conscious foodies and bakers! With more than half a million copies of their books in print, Jeff Hertzberg, MD and Zoë François have proven that people want to bake their own bread, so long as they can do it quickly and easily. But what about people with celiac disease or gluten sensitivity? They want to eat well too, but gluten is everywhere: in cakes, pastas, desserts, gravyeven in beer and Scotch whiskey. But the thing they miss most? Bread.Based on overwhelming requests from their readers, Jeff Hertzberg and Zoë François have returned to their test kitchens to create an entirely gluten-free bread cookbookmost of the recipes that readers loved in Artisan Bread in Five Minutes a Day appear here in a gluten-free version. In just f

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Book SynopsisAutPlay Therapy is a behavioral play-based treatment approach to working with children and adolescents with autism spectrum disorder and other developmental disabilities. This innovative new model contains a parent-training component (wherein the therapist trains parents to do directive play therapy interventions in the home) and can be utilized in any setting where children and adolescents with an autism disorder, ADHD, dysregulation issues, or other neurodevelopmental disorders are treated. This comprehensive resource outlines the AutPlay Therapy process and offers a breakdown of treatment phases along with numerous assessment materials and over 30 directive play therapy techniques.Table of ContentsIntroduction. 1 Autism Spectrum Disorder. 2 Developmental Disabilities. 3 Influences on AutPlay Therapy. 4 Play Therapy. 5 Behavioral Therapy. 6 AutPlay Therapy Approach. 7 Emotional Regulation Ability 8 Social Skills Development. 9 Connection (Relationship Development). 10 Parent Training. 11 Phases of AutPlay Therapy. 12 AutPlay Follow Me Approach. 13 Research. 14 Case Studies. 15 Emotional Regulation Interventions. 16 Social Skills Interventions. 17 Connection Interventions. Appendix A: Therapy Inventories. Appendix B: Therapy Treatment Plan Profile. Appendix C: Additional Play Based Treatments. Appendix D: Apps for Autism and Developmental Disorders. Appendix E: Additional Resources.

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Book SynopsisWhen it was first published in France in 1961 as Folie et DÃraison: Histoire de la Folie à l'Ãge Classique, few had heard of a thirty-four year old philosopher by the name of Michel Foucault. By the time an abridged English edition was published in 1967 as Madness and Civilization, Michel Foucault had shaken the intellectual world. This translation is the first English edition of the complete French texts of the first and second edition, including all prefaces and appendices, some of them unavailable in the existing French edition. History of Madness begins in the Middle Ages with vivid descriptions of the exclusion and confinement of lepers. Why, Foucault asks, when the leper houses were emptied at the end of the Middle Ages, were they turned into places of confinement for the mad? Why, within the space of several months in 1656, was one out of every hundred people in Paris confined?Shifting brilliantly from Descartes and early EnlighTrade Review'One of the major works of the twentieth century is finally available in English. This comprehensive translation finally overcomes one of the great divisions within the world of reason; an occasion to revisit Madness and Civilization as it was written.’ – Paul Rabinow, University of California, Berkeley, USA‘Now, at last, English speaking readers can have access to the depth of scholarship that underpins Foucault’s analysis: I have no doubt that this long awaited translation will have a transformative effect on a new generation of readers.’ - Nikolas Rose, London School of Economics, UK'…we are in the presence of a principal thesis that is truly original, by a man whose personality, whose intellectual "dynamism", whose talent for exposition all qualify him for high education' - Henri Gouhier, Principal Examiner of Foucault's Thesis' ... it returns a fragment of 'nature' to history and transforms madness, something we take to be a medieval phenomenon, into a phenomenon of civilization.' - Roland Barthes'Without a shadow of a doubt, the most original, influential and controversial text in this field during the last forty years. It remains as challenging now as on first publication. Its insights have still not been fully appreciated and absorbed.' - Roy Porter'This is quite an exceptional book of very high calibre - brilliantly written, intellectually rigorous, and with a thesis that thoroughly shakes the assumptions of traditional psychiatry.' - R.D. Laing'Extraordinary…rich and insistent, and almost unreasonable in its necessary repetitions.' - Maurice Blanchot'This magnificent book…requires a mind that is capable of being in turn a historian, a philosopher, a psychologist, and a sociologist-never simply one of these…This is not a method that could be offered as an example; it is not within the reach of just anybody. Something more than talent is necessary.' - Fernand Braudel, Annales'I have just finished reading your great book…You are a real explorer.' - Gaston Bachelard, in a letter to Michel Foucault'Scarcely any philosopher working on the history of philosophy, or historian working on the history of institutions, social science or sexuality can avoid confronting the challenge of Foucault's books.' - Michael Ignatieff, Times Literary Supplement'Scarcely any philosopher working on the history of philosophy, or historian working on the history of institutions, social science or sexuality can avoid confronting the challenge of Foucault's books.' - Michael Ignatieff, Times Literary Supplement'Without a shadow of a doubt, the most original, influential and controversial text in this field during the last forty years. It remains as challenging now as on first publication. Its insights have still not been fully appreciated and absorbed.' – Roy Porter'Extraordinary…rich and insistent, and almost unreasonable in its necessary repetitions.' – Maurice BlanchotTable of ContentsForeword: History and Significance of Foucault’s History of Madness Prefaces 1. 1961 Edition 2. 1972 Edition Part 1 1. Stultifera Navis 2. The Great Confinement 3. The Correctional World 4. Experiences of Madness 5. The Insane Part 2 1. The Madman in the Garden of Species 2. The Transcendence of Delirium 3. Figures of Madness 4. Doctors and Patients Part 3 1. The Great Fear 2. The New Division 3. The Proper Use of Liberty 4. Birth of the Asylum 5. The Anthropological Circle Appendices 1. Réponse à Derrida (Michel Foucault Derrida e no kaino Paideia (Tokyo) February 1972) 2. La Folie, l'absence d'oeuvre Appendix 1 of 1972 Edition 3. Mon corps, ce papier, ce feu Appendix 2 of 1972 Edition Notes Bibliography Critical Bibliography on Foucault’s History of Madness

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Book SynopsisPublisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.Comprehensive, single-source coverage of the entire first year of medical school!Table of ContentsContributing AuthorsFaculty ReviewersPrefaceAcknowledgmentsHow to Use This BookHow to ContributeChapter 1: Anatomy and HistologyCellular Anatomy and HistologyGross Anatomy and HistologyChapter 2: Behavioral ScienceEpidemiologyStatisticsDisease PreventionEthicsLife CyclePsychologyChapter 3: BiochemistryMolecular BiologyNucleotide SynthesisMutations and DNA RepairEnzymesThe CellConnective TissueHomeostasis and MetabolismAmino AcidsNutritionFed Versus Unfed StateLaboratory Tests and TechniquesGeneticsChapter 4: EmbryologyChapter 5: MicrobiologyBacteriologySpirochetesMycologyParasitologyVirologyMicrobiology: SystemsAntimicrobialsChapter 6: ImmunologyPrinciples of ImmunologyPathologyChapter 7: PathologyChapter 8: General PharmacologyPharmacodynamicsPharmacokineticsToxicologyIndexAbout the Editors

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Book SynopsisWhat you are doing I cannot do, what I’m doing you cannot do, but together we are doing something beautiful for God, and this is the greatness of God’s love for us.” —Mother Teresa, from Where There Is Love, There Is God In this book, Mother Teresa’s relationship with God and her commitment to those she served—the poorest of the poor—is powerfully explored in her own words. Taken largely from her private lessons to her sisters, published here for the first time, Where There Is Love, There Is God unveils her extraordinary faith in, and surrender to, God’s will.Love is perhaps the word that best summarizes Mother Teresa’s life and message. She sought to be an extension of God’s heart and hands in today’s world. She was called to be a missionary of charity, a carrier of God’s love to each person she met, especially those most in need. Yet she did not think that t

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Book SynopsisA revelatory exploration of the Jewish roots of the Last Supper that seeks to understand exactly what happened at Jesus’ final Passover.   “Clear, profound and practical—you do not want to miss this book.”—Dr. Scott Hahn, author of The Lamb’s Supper and The Fourth Cup    Jesus and the Jewish Roots of the Eucharist shines fresh light on the Last Supper by looking at it through Jewish eyes. Using his in-depth knowledge of the Bible and ancient Judaism, Dr. Brant Pitre answers questions such as: What was the Passover like at the time of Jesus? What were the Jewish hopes for the Messiah? What was Jesus’ purpose in instituting the Eucharist during the feast of Passover? And, most important of all, what did Jesus mean when he said, “This is my body… This is my blood”? To answer these questions, Pitre explores ancient Jewish beliefs about the

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Book SynopsisChanging the parent-child dynamic to improve anxiety symptoms.Trade Review"What loving parent would not want to end the suffering of their child? Yet anxiety will run roughshod over families, taking advantage of responses that, on the surface, seem so caring. By the time they arrive in treatment, parents feel helpless and exhausted, while the worried child has become dependent on reassurance and overprotection. McCurry expertly elucidates for readers the tactics of therapeutic change that will stabilize the family system, empower the parents, and foster resilience in the child." -- Reid Wilson, PhD, co-author Anxious Kids, Anxious Parents: Seven Ways to Stop the Worry Cycle and Raise Courageous and Independent Children "Work with parents of anxious children is becoming richer and more nuanced as practitioners used to doing parent training, communication skills work, and traditional cognitive behavior therapy begin to use acceptance and mindfulness-based therapies as well. This wise and well-written volume will help provide that sense of nuance and balance. It is not a treatment protocol, nor is it dedicated to any one approach; it is a guidebook, helping you to use your existing skills in more sophisticated ways and to learn new skills and approaches without having to abandon what you already know. Highly recommended." -- Steven C. Hayes, PhD, Co-developer of Acceptance and Commitment Therapy and author of Get Out of Your Mind and Into Your Life "This book is an incredibly valuable resource for every clinician working with anxious children and their parents. McCurry expertly integrates evocative clinical vignettes with a sophisticated, yet easily understood, biopsychosocial model. He explains the negative parent-child interactions so common in the families of anxious youth and provides an elegant and effective therapeutic approach for enhancing family communication and resolving conflict. Drawing from the cognitive-behavioral, functional analytic, acceptance, and mindfulness literatures, this book provides clear guidance and an abundance of clinical "pearls" for teaching parents how to create a healthy and resilient home environment." -- John Piacentini, PhD, ABPP, President, Society for Clinical Child and Adolescent Psychology, Director, Child OCD, Anxiety, and Tic Disorders Program, UCLA Semel Institute

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Book SynopsisBorn out of the excitement of a convergence of ideas and passions, this book provides a synthesis of the work of researchers, clinicians, and theoreticians who are leaders in the field of trauma, attachment, and psychotherapy.Trade Review"Trauma has returned to center stage in our clinical and theoretical thinking. This book enriches our understanding of trauma from all the pertinent perspectives. It will be invaluable for all in the field, both for treating people and thinking about trauma. " -- Daniel S. Stern, MD, Adjunct Professor of Psychiatry, Cornell Medical School; author of The Interpersonal World of the Infant"This remarkable collection of articles summarizes much of the best current thinking on trauma, attachment research, neurobiology, and its application to psychodynamic psychotherapy. It is an outstanding achievement." -- Beatrice Beebe, PhD, Clinical Professor of Psychology in Psychiatry, NYS Psychiatric Institute, Columbia University"This volume provides much more than a compelling set of models for healing trauma—it also delivers a state of the art account of the causes and consequences of trauma. The editors, Marion Solomon and Daniel Siegel, are to be congratulated for bringing together so cohesively some of the most powerful voices in the field. This book will clarify understanding of trauma through eight chapters presenting the latest significant findings in neuroscience, developmental and clinical psychology, and psychiatry. Those training or working with victims of trauma and their families will find this resource indispensable." -- Howard Steele, PhD, Director, Attachment Research Unit, University College, London; Editor, Attachment & Human Development"This is an extraordinary book. It provides an up-to-the-minute integration of attachment trauma and neuroscience. Each contribution provides an essential chart to guide the therapist in understanding this most difficult group of clients. Taken together, the chapters compose a veritable atlas mapping this world of the unbearable and unthinkable. Without such theoretical and practical guides, the therapist working with trauma can become as vulnerable as the client she or he attempts to heal." -- Peter Fonagy, PhD, FBA, Freud Memorial Professor of Psychoanalysis at University College London and Director, Child and Family Center, The Menninger Clinic, Topeka, KS

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Book SynopsisThe properties and function of human communication.

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Book SynopsisIn this work, Karen Horney explores the basic structure of neuroses in the context of their cultural assumptions.

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Book SynopsisThis synoptic history of the life and teachings of Christ was originally published in 1890 as an aid for clergymen and other instructors in biblical texts. James combines the four gospel accounts of the life of Jesus into one useful text with scriptural references in the margins for accurate study and quotation, complete with a list of individual variations among the sources. Written in the language of the Revised Version, this book will be useful to anyone involved in Bible study or with an interest in Christian theology.Table of ContentsPreface; Note on the Sermon on the Mount; Note on the marginal references; Tables to find any passage; Table of our Lord's miracles; Table of our Lord's parables; Table of our Lord's principal discourses; The gospel history; Variations; References to sections in S. D. Waddy's harmony.

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Book SynopsisAn accessible, passionate indictment of the ignorance, opportunism and social indifference that enriched lawyers and a few plaintiffs, though the available scientific evidence was against them. New York Times Book Review, Notable Books of 1996Trade Review"[A] sober and rigorous examination of the controversy over silicone breast implants . . . an important statement, not just about silicone implants, but about other matters at the intersection of law, science, and opinion. [Dr. Angell’s] book is . . . a warning that rationality, like much else in the fragile porcelain of society, can be weakened by lack of vigilance." -- New York Times"An indispensable guide to the breast implant madness—litigation that will forever stand as a monument to the inability of our civil justice system to sort out latter-day Ptolemies from Galileos." -- Wall Street Journal"Marcia Angell's outstanding book explains clearly and fairly the combination of greed, fear, ignorance, junk science, and media hype that created this national litigation nightmare. Everyone interested in the tort system, science, and medicine should heed the lessons that Dr. Angell teaches." -- Shirley M. Hufstedler, former U.S. Secretary of Education

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Book SynopsisProviding a practical and accessible guide, this book enables readers to quickly build up knowledge and understanding of toxicology applications taking the reader from basic theory to an advanced basics level dealing with specific issues like pesticides, alcohol, and cigarettes.Table of ContentsForeword xxi Preface xxiii Acknowledgment xxv 1 Welcome to the World of Toxicology 1 1.1 Chemicals – They Are All Around Us 1 1.2 Synthetic or Naturally Occurring Chemicals – Which Are “Safer”? 1 1.3 Chemical Control Regulations 2 1.4 Perception of Chemical Risk 3 1.5 Why Is Toxicology Important? 4 1.6 Summary 4 2 Basic Toxicological Terminology 5 2.1 The Cell 5 2.1.1 Stem Cells, Somatic Cells, and Germ Cells 5 2.2 Homeostasis7 2.3 Adaptation and Cell Injury 7 2.4 Cellular Responses to Injury 7 2.5 Mode of Action and Mechanism of Action 9 2.6 Adverse Effects 9 2.7 Biological and Statistical Significance 10 2.8 Local and Systemic Effects 11 2.9 How Chemicals Cause Harm 11 2.10 Acute and Chronic Exposures 12 2.11 Chemical Interactions in Mixtures 14 2.12 Summary 15 3 The Dose Makes the Poison 19 3.1 Dose– Response and Dose–Effect Relationships 19 3.2 Internal and External/Exposure Dose 20 3.3 The Dose Makes the Poison: Dose–Response/Effect Curves 21 3.4 No Observed Adverse Effect Level (NOAEL) 23 3.5 Lowest Observed Adverse Effect Level (LOAEL) 24 3.6 What Affects the NOAEL and LOAEL? 24 3.7 No Observed Effect Level (NOEL) 24 3.8 Summary 24 4 Toxicokinetics 27 4.1 Why Is Toxicokinetics So Useful? 28 4.2 ADME: Absorption, Distribution, Metabolism, and Excretion 29 4.3 Biotransformation (Metabolism) 36 4.4 Bioavailability and Area Under the Curve (AUC) 38 4.5 Assessment Approaches 39 4.6 Summary 40 5 Factors That Modify Toxicity 45 5.1 Lifestyle Factors – Alcohol and Tobacco 45 5.2 Influence of Age 46 5.3 Health Status 46 5.4 Nutritional Status – Diet 47 5.5 Sex 48 5.6 Adaptation 48 5.7 Genetic Variability 48 5.8 Summary 49 6 Local Effects 53 6.1 Irritants and Corrosives 53 6.2 Skin Structure 54 6.3 Irritant Contact Dermatitis 56 6.4 Chemical Corrosives 60 6.5 The Skin as a Target Organ – Severity of Effect 60 6.6 Chemical Irritants and Other Exposure Routes 61 6.7 Summary 62 7 Systemic Effects 65 7.1 Chemical Allergies 66 7.2 Genetic Toxicology 79 7.3 Carcinogenicity 91 7.4 Reproductive and Developmental Toxicology 100 7.4.10 Maternal Mediated Toxicity 119 8 Target Organ Toxicity 123 8.1 The Liver 124 8.2 The Kidney 139 8.3 The Immune System 151 8.4 Hematopoietic System and Blood 167 8.5 The Nervous System 176 8.6 The Respiratory Tract 196 8.7 The Endocrine System 208 9 Assessment Methods 227 9.1 Assessment of Irritation and Corrosive Effects 228 9.2 Assessment of Acute Toxicity 239 9.3 Repeated 9.4 Assessment of Carcinogenicity 259 9.5 Assessment of Genetic Toxicity 267 9.6 Assessment of Reproductive and Developmental Effects 283 9.7 Assessment of Skin and Respiratory Sensitization 295 10 Alternative Methods to Animal Testing 307 10.1 The Drive for Alternative Methods 307 10.1.1 A Different Approach? 308 10.3 In Vitro and Ex Vivo Methods 308 10.4 Twenty‐ First Century Toxicity Testing 310 10.5 Physicochemical Data and Their Use in Hazard Identification and Exposure Assessment 314 10.6 Summary 317 11 Human Health Risk Assessment 321 11.1 Human Health Risk Assessments – Prospective and Retrospective 321 11.2 Risk, Hazard, and Exposure 322 11.3 Chemical Risk Assessments 323 11.4 Linear Dose Response – Nonthresholded Effects 333 11.5 Exposure Assessment 336 11.6 Risk Characterization – Do We Have a Problem? 340 11.7 Summary 341 Glossary 345 Index 355

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Book SynopsisThe revised edition of this indispensable resource presents the tools clients need to learn and practice any Dialectical Behavior Therapy (DBT) skill or set of skills. Clients get quick access to the materials recommended for a particular skills training program, with more than 225 reproducible handouts and worksheets in all. In the revised edition, handouts and worksheets for each skill are grouped together, making the book even easier to use. All four DBT skills modules are included--mindfulness, interpersonal effectiveness, emotion regulation, and distress tolerance--each with a brief introduction written expressly for clients. In a convenient, spiral-bound 8 1/2 x 11 format, the book is updated throughout with more inclusive language and changes in technology and daily life.

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Book Synopsis

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