Diseases and disorders Books
Springer Verlag, Singapore Antibiotic Pharmacokinetic/Pharmacodynamic
Book SynopsisThis book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.Table of Contents1. Basic Pharmacokinetic Principles.- 2. Antibiotic Pharmacodynamics.- 3. Physiological Manifestations of Critical Illness.- 4. Dosing in Obese Critically Ill Patients.- 5. Hypoalbuminemia and Altered Protein Binding.- 6. Antibacterial Pharmacokinetic/Pharmacodynamic Considerations in the Critically ill.- 7. Augmented Renal Clearance.- 8. Antibiotic Dosing During Extracorporeal Membrane Oxygenation.- 9. Therapeutic Drug Monitoring: More than Avoiding Toxicity.- 10. Generic and Optimised Antibacterial Dosing Strategies in the Critically Ill.- 11. Antifungal PK/PD in the Critically Ill.- 12. Antibiotic Dosing in Pediatric Critically Ill Patients.- 13. Antibiotic Stewardship in the Intensive Care Unit.
£98.99
World Scientific Publishing Company Fighting The Virus How Disease Modeling Can
Book Synopsis
£90.00
Springer Verlag, Singapore Antibiotic Resistant Bacteria: A Challenge to
Book SynopsisThis book summarizes the emerging trends in the field of antibiotic resistance of various gram-negative and gram-positive bacterial species. The ability of different species of bacteria to resist the antimicrobial agent has become a global problem. As such, the book provides a comprehensive overview of the advances in our understanding of the origin and mechanism of resistance, discusses the modern concept of the biochemical and genetic basis of antibacterial resistance and highlights the clinical and economic implications of the increased prevalence of antimicrobial resistant pathogens and their ecotoxic effects. It also reviews various strategies to curtail the emergence and examines a number of innovative therapeutic approaches, such as CRISPR, phage therapy, nanoparticles and natural antimicrobials, to combat the spread of resistance.Table of ContentsChapter 1. Emergence of antibiotic resistant bacteria.- Chapter 1.1. Era of antibiotic discovery.- Chapter 1.2. Emergence of antibiotic resistant microbes immediate after the discovery of antibiotics.- Chapter 1.3. Newly discovered antibiotics of 21st century.- Chapter 2. Impact of antibiotic resistant bacteria on different field.- Chapter 2.1. Antibiotic resistance: Role and pattern in different class of bacteria.- Chapter 2.2. Effect of drug resistant bacteria on agriculture, medical society, livestock and environment.- Chapter 3. Antibiotic resistance: Pattern and Mechanisms.- Chapter 3.1. Intrinsic antibiotic resistant mechanism in bacteria.- Chapter 3.2. Extrinsic antibiotic resistant mechanism in bacteria .- Chapter 3.3. Chemical mediated alteration of antibiotics.- Chapter 4.1. Novel strategies for overcoming of antibiotic resistant mechanisms.- Chapter 4.2. Collapsing of antibiotic resistance with the help of genetic approaches.- Chapter 4.3. Bacteriophage: A new hope for the control of antibiotic resistant bacteria.- Chapter 4.4. Nanotechnology: A 21st Century approach towards the control of antibiotic resistant bacteria.- Chapter 5. Future Prospects.
£123.49
Springer Verlag, Singapore Sphingolipid Metabolism and Metabolic Disease
Book SynopsisThis book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.Table of ContentsChapter 1: Sphingolipids and Cholesterol.- Chapter 2: Sphingolipids in adipose: kin or foe?.- Chapter 3: De novo sphingolipid biosynthesis in atherosclerosis.- Chapter 4: Serine Palmitoyltransferase Subunit 3 and Metabolic Diseases.- Chapter 5: Molecular mechanisms of sphingolipid transport on plasma lipoproteins.- Chapter 6: Sphingosine 1-phosphate metabolism and signaling.- Chapter 7: Sphingomyelin synthase family and phospholipase Cs.- Chapter 8: Sphingolipid metabolism and signaling in endothelial cell functions.- Chapter 9: Cholesterol metabolism in chronic kidney disease: physiology, pathologic mechanisms, and treatment.- Chapter 10: Sphingolipids and asthma.- Chaper 11: Manifold Roles of Ceramide Metabolism in Nonalcoholic Fatty Liver Disease and Liver Cancer.- Chapter 12: Drug development in the field of sphinogolipid metabolism.- Chapter 13: Rare diseases in glycosphingolipid metabolism.
£125.99
Springer Verlag, Singapore Drug Repurposing for Emerging Infectious Diseases
Book SynopsisThis book presents drug repurposing strategies to combat infectious diseases and cancer. It discusses key experimental and in silico approaches for modern drug repositioning, including signature matching, molecular docking, genome-wide associated studies, and network-based approaches aided by artificial intelligence. Further, the book presents various computational and experimental strategies for better understanding disease mechanisms and identify repurposed drug candidates for personalized pharmacotherapy. It also explores the databases for drug repositioning, summarizes the approaches taken for drug repositioning, and highlights and compares their characteristics and challenges. Towards the end, the book discusses challenges and limitations encountered in computational drug repositioning.Table of ContentsChapter 1_Repurposing of drugs: Introduction to technologies and application. - Chapter 2_The value added medicine: Pharmacovigilance re-evaluated. - Chapter 3_Polypharmacology and drug repurposing. -Chapter 4_Comparative transcriptome analysis for infectious diseases towards the identification of cellular pathways for drug repositioning. -Chapter 5_Repurposing of drugs for the treatment of microbial diseases. -Chapter 6_RNA-dependent RNA polymerase (RdRp) - a potential therapeutic approach for Coronavirus drug repositioning. -Chapter 7_Drug repurposing for emerging and re-emerging infectious diseases. -Chapter 8_Drug repurposing for the control of COVID-19.-Chapter 9_Repurposing of anti-inflammatory agents in the potential treatment of SARS 2CoV -2 infection. -Chapter 10_Repurposing of immune-modulators for the treatment of cancer with a QSAR approach. -Chapter 11_ Repurposing Cancer drugs towards antiviral targets in developing countries. -Chapter 12_Repurposed drugs for hematological malignancies. -Chapter 13_Reverse translational approach in repurposing of drugs for anticancer therapy. -Chapter 14_Repurposing of Minocycline: a tetracycline antibiotic for neurodegenerative disorders. -Chapter 15_Drug repurposing for Neglected diseases: Approaches, challenges and promising candidates.
£161.99
World Scientific Publishing Co Pte Ltd Computational Biology Of Cancer: Lecture Notes
Book SynopsisThe book shows how mathematical and computational models can be used to study cancer biology. It introduces the concept of mathematical modeling and then applies it to a variety of topics in cancer biology. These include aspects of cancer initiation and progression, such as the somatic evolution of cells, genetic instability, and angiogenesis. The book also discusses the use of mathematical models for the analysis of therapeutic approaches such as chemotherapy, immunotherapy, and the use of oncolytic viruses.Table of ContentsCancer and Somatic Evolution Mathematical Modeling of Tumorigenesis Cancer Initiation: One-Hit and Two-Hit Stochastic Models Microsatellite and Chromosomal Istability in Sporadic and Familial Cancers Cellular Origins of Cancer Costs and Benefits of Chromosomal Instability DNA Damage and Genetic Instability Tissue Aging and the Development of Cancer Basic Models of Tumor Inhibition and Promotion Mechanisms of Tumor Neovascularization Cancer and Immune Responses Therapeutic Approaches: Viruses as Anti-Tumor Weapons
£80.75
World Scientific Publishing Co Pte Ltd Primary Intraocular Lymphoma
Book SynopsisEssential reading for both medical students and academics in the fields of ophthalmology, neurology and oncology, this is the first textbook to cover the subject of primary intraocular lymphoma (PIOL). The book serves to educate ophthalmologists, neurologists and oncologists on a disease process that is often difficult to diagnose. To help readers recognize the malignancy, a presentation of common and less frequently occurring clinical manifestations of the disease is given. The book provides ophthalmologists the guidelines on current diagnostic and therapeutic modalities as well as the historical background of PIOL.Table of ContentsDefinition of Primary Intraocular Lymphoma; History of Primary Intraocular Lymphoma (1950s-1970s); Classification of Lymphomas; Epidemiology of Primary Intraocular Lymphoma; Clinical Manifestations of PIOL; Imaging; Pathology; Immunology of PIOL; Diagnostic Approaches; Management and Treatment of PIOL; Prognosis in PIOL; Hypotheses on the Origin of PIOL; Experimental Models of PIOL; Summary and Algorithm; The Future of PIOL; Case Illustrations.
£108.00
World Scientific Publishing Co Pte Ltd Vascular Smooth Muscle: Structure And Function In
Book SynopsisThis book presents key concepts in the structure and function of vascular smooth muscle cells in health and disease. Supplemental reading may be drawn from the extensive references listed at the end of each chapter. Vascular smooth muscle cell is the major cell type in blood vessels. Dysfunction of vascular smooth muscle cells is an important cause of vascular diseases, for example, atherosclerosis, hypertension, and circulatory shock. Vascular smooth muscle cells are phenotypically plastic, capable of switching between two major phenotypes — contractile/differentiated phenotype and invasive/proliferative phenotype in response to environmental clues. Chapter 1 introduces the major areas of research presented in this monograph. Chapters 2 to 4 address the structure and function of the contractile/differentiated phenotype of vascular smooth muscle cell. Chapters 5 and 6 address the developmental basis of vascular smooth muscle cell phenotype and structure and function of podosomes (invasive organelles) in the invasive/proliferative phenotype of vascular smooth muscle cell. Chapters 7 to 9 address the role of vascular smooth muscle cell dysfunction in vascular diseases — atherosclerosis, hypertension, and circulatory shock.
£100.80
World Scientific Publishing Co Pte Ltd Information Approach To Mitochondrial
Book SynopsisThe monograph applies sophisticated topological symmetry tools to biological applications of information theory, along with a Black-Scholes model invocation of the Data Rate Theorem which links information and control theories. The focus is on statistical mechanics and other models that explore pathological phase transitions — driven by changes in available rates of mitochondrial free energy — in physiological functions, a cutting-edge topic in the study of chronic disease. One of the key focuses is Alzheimer's disease — a relatively simple canonical example.Table of ContentsMathematical Preliminaries; A Symmetry-Breaking Model; A Data Rate Theorem Model; A Mutual Information Model; A Fragment Size Model; Extending the Perspective; Embodiment and Environment; Chronic Inflammation; What is to be Done?; Mathematical Appendix;
£55.10
Springer Artificial Intelligence in Human Health and
Book Synopsis1. The Magic of Artificial Intelligence-1.- 2. Magic of Artificial Intelligence-2.- 3. Deep Reinforcement Learning in Medical Science: Methods, Applications, and Future Directions.- 4. The problem of Generialization and Explainability in deep learning algorithms.- 5. Artificial Intelligence and Omics in Health and Diseases.- 6. Artificial Intelligence in Biomarker Discovery and Disease Diagnosis.- 7. Artificial Intelligence in Biomarker Discovery and Disease Diagnosis-2.- 8. Radiogenomics and Artificial Intelligence in Health and Diseases.- 9. Artificial Intelligence and the Use of Imaging Modalities in Biomedical Sciences.- 10. Artificial Intelligence in Cardiovascular Diseases.- 11. Artificial Intelligence in Obesity and Diabetes.- 12. AI-Powered Revolution in Infectious Disease Management: From Early Diagnostics to Drug Discovery.- 13. Artificial Intelligence in Oncology.- 14. Artificial Intelligence in Precision Oncology, Genomic Medicine and Disease Monitoring.- 15. Artificial Intelligence in Drug Discovery and Drug Target Interactions.- 16. Artificial Intelligence and Cancer Immunotherapy.- 17. Deep Learning Based Techniques for Detection of Cancer.
£161.99
