Clinical and internal medicine Books

Book SynopsisPublisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.The gold-standard text in pediatric hospital medicine â updated and streamlined for todayâs practiceHailed by reviewers and clinicians alike, Comprehensive Pediatric Hospital Medicine has  become the specialtyâs cornerstone text. Edited by five leading figures in pediatric hospital medicine, this acclaimed resource brings you the most up-to-date, evidence-based approaches to inpatient pediatric care from experts in their fields.  Comprehensive Pediatric Hospital Medicine, Second Edition opens with an informative introductory section that defines hospital medicine and addresses general issues of hospitalist practice and administration.  This includes importTable of ContentsPart I: General Issues of Inpatient Pediatric MedicineSection A: Hospitalists and Hospitalist SystemsSection B: Improving the Quality of Care for Hospitalized ChildrenSection C. Caring for the PatientSection D: Hospitalist Service AdministrationSection E: Ethics, The Law, and Pediatric Clinical ResearchSection F: Hospitalists’ Work: Present and FuturePart II: Common Presenting Signs and SymptomsPart III: Systems ApproachSection A: NeonatologySection B: Fluids and ElectrolytesSection C: Infectious DiseasesSection D: PulmonologySection E: CardiologySection F: EndocrinologySection G: Gastroenterology and NutritionSection H: RheumatologySection I: NephrologySection J: HematologySection K: OncologySection L: NeurologySection M: Genetics and MetabolismSection N: Allergy and ImmunologySection O: Surgical IssuesSection P: DermatologySection Q: PsychiatrySection R: Adolescent MedicineSection S: Child Abuse and NeglectSection T: Toxins, Substance Abuse, and Environmental ExposuresSection U: Care of the Medically Complex ChildPart IV: Procedures

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Book SynopsisTrade Review"This is definitely a nice supplement to my knowledge while combining my specific expertise as a medication expert. The content presented is clinically relevant and accurate, including the most up-to-date, evidence-based recommendations. The book even includes useful notes describing current clinical debates or controversial scenarios. The authors provide "rules of thumb" that are used in clinical practice and may be difficult to find in medical literature." ©Doody's Review Service, 2022, Marc Crane, PharmD (Penn Medicine) Doody's Score: 4 Stars!Table of Contents1. Introduction 2. The Process of Diagnosing 3. Nuances and Characteristics of Tests 4. Anticoagulation Management in the Periprocedural Period 5. Glycemic Considerations for Tests and Procedures 6. Introduction to Anesthesia 7. Abdominal Ultrasound 8. Adrenocorticotropic Hormone Stimulation Test 9. Ankle-Brachial Index Test 10. Atrial Fibrillation Ablation 11. Bariatric Surgery 12. Bladder Scan 13. Bronchoscopy 14. Carotid Endarterectomy 15. Chest Tube 16. Chest X-Ray 17. Computed Tomography Scan 18. Continuous Glucose Monitoring 19. Continuous Renal Replacement Therapy 20. Coronary Artery Bypass Grafting 21. Culture - Blood 22. Culture - Sputum 23. Culture - Urine 24. Dexamethasone Suppression Test 25. Echocardiography 26. Electrocardiography 27. Electroencephalography 28. Endoscopic Retrograde Cholangiopancreatography 29. Gastric Emptying Study 30. Gastrointestinal Endoscopy - Capsule 31. Gastrointestinal Endoscopy - Lower 32. Gastrointestinal Endoscopy - Upper 33. Hemodialysis 34. Hemodialysis Access 35. Hepatobiliary Scintigraphy 36. Implantable Cardiac Devices 37. Intravenous Access 38. Lower Extremity Venous Duplex Ultrasound 39. Lumbar Puncture 40. Magnetic Resonance Cholangiopancreatography 41. Magnetic Resonance Imaging 42. Nasogastric Tubes 43. Nephrostomy Tubes 44. Oxygen Supplementation 45. Patient-Controlled Analgesia 46. Percutaneous Coronary Intervention 47. Percutaneous Endoscopic Gastrostomy Tubes 48. Peritoneal Dialysis 49. Positron Emission Tomography 50. Renal Ultrasound 51. Sleep Study 52. Speech-Language and Swallow Evaluations 53. Stress Tests 54. Thyroid Ablation 55. Thyroid Uptake and Scan 56. Transcatheter Aortic Valve Replacement 57. Transjugular Intrahepatic Portosystemic Shunt 58. Urinalysis 59. Urinary Catheters 60. Ventilation-Perfusion Scan

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Book SynopsisThis book provides comprehensive coverage of speech and language disorders arising from pathological processes involving the subcortical structures of the brain. It gives an understanding of these disorders in terms of their neuropathological basis, clinical symptomatology and prognosis.Table of ContentsSECTION A: INTRODUCTION. 1. Subcortical Involvement in Speech and Language: An Introduction and Historical Perspective. 2. Neuroanatomy and Functional Neurology of the Subcortical Region. SECTION B: SUBCORTICAL LANGUAGE DISORDERS. 3. Models of Subcortical Participation in Language. 4. Language Disorders Associated with Striatocapsular and Thalamic Lesions. 5. Pallidal and Thalamic Involvement in Language: Evidence from Stereotactic Surgical Studies. 6. Role of the Subthalamic Nucleus in Language. 7. Influence of the Cerebellum on Language Function. 8. Degenerative Subcortical Syndromes: Aetiology, Clinical Features, Medical Treatment and Associated Language Disorders. 9. Assessment and Treatment of Subcortical Language Disorders. SECTION C: SUBCORTICAL SPEECH DISORDERS. 10. Role of the Subcortical Structures in Speech Motor Control. 11. Dysarthria Associated with Subcortical Pathologies. 12. Subcortical Dysarthrias: Assessment and Treatment.

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Book SynopsisThis multi-contributed text, co-ordinated by one of the leading authorities in the field, is a unique resource to cover in depth the management of the important issue of Nosocomial Pneumonia in respiratory medicine and critical care. This disease presents the clinician with a variety of challenges, in both diagnosis and management, all of which represent a significant concern for the welfare of patients whose ability to combat infection is frequently already compromised. Nosocomial Pneumonia: Strategies for Management is dedicated specifically to this most common hospital acquired respiratory infection and reviews important new advances in therapeutics, including drug resistance. It is an essential resource for all postgraduates and specialist physicians in pulmonology and infectious diseases.Trade Review"Nosocomial Pneumonia achieves its stated goal of seeking to present current knowledge on the pathophysiology, clinical presentation, diagnosis, and treatment of nosocomial pneumonia. Clinicians interested in this topic will find the text a useful and worthwhile compilation." (Journal of the American Medical Association, December 3, 2008) “The main purpose of this book is to give physicians who care for patients at risk for nosocomial pneumonia a concise and up-to-date reference and management guide, and I would say the book succeeds in that task. It is a concise, well-referenced overview…. This is a useful text that compiles a substantial body of information … in a convenient source. The major strengths of the book are the authoritative international list of contributors and the clear focus.” (Respiratory Care, November 2008) "The book is well-organized, well-written, easy to read and understand and timely in its subject matter." (ADVANCE for Respiratory Care Practitioners) "This is a good overview of an important subject." (Doody's Book Reviews)Table of ContentsPreface. List of Contributors. Abbreviations. 1. Health Care Associated-Pneumonia: Epidemiology, Microbiology and Clinical Outcomes (Dr. Marcos I. Restrepo and Dr. Antonio Anzuelo, San Antonio, Texas. US). 2. Prevention of Hospital-Acquired Pneumonia (Dr. Rafael Sierra and Antonio Gordillo, Cádiz, Spain). 3. Role of the microbiology laboratory in the diagnosis of ventilator-associated pneumonia (Dr. Emilio Bouza, Dra. Almudena Burillo, Dra. Patricia Muñoz, Madrid, Spain). 4. Pathophysiology of Pneumonia (Dra Amalia Alcón, Dr. Mauricio Valencia, Dr. Antoni Torres, Barcelona, Spain). 5. Clinical approach to the patient with HAP (Dr. Jordi Rello, Tarragona, Spain & Dr. Miguel Gallego, Sabadell, Spain). 6. Pneumonia due to Pseudomonas aeruginosa (Dr. Jordi Vallés and Dra. Dolors Marisca, Sabadell. Spain). 7. Hospital acquired-pneumonia caused by Staphylococcus aureus (Dra. Despoina Koulenti, Athens, Greece; Dr. Kemal Agbaht, Ankara, Turkey). 8. Nosocomial pneumonia by Acinetobacter baumannii (Dr. José Garnacho-Montero and Da. Eugenia Pachón, Dr. J.M. Cisneros, Sevilla, Spain). 9. Fungal pneumonia (Dr. George Dimopoulos, Dr. E. Papadomichelakis, Dr. P. Kopteridis, Athens, Greece). 10. General pharmacologic considerations and dose adjustment in antibiotic therapy for HAP (Dr. Pierluigi Viale and Dr. Federico Pea, Udine, Italy). 11. Minimally Invasive Diagnostic Strategy in Immunocompromized Patients with Pulmonary Infiltrates (Dra. Sandra. De Miranda and Dra. Élie Azoulay, Paris, France). 12. Pneumonia in trauma patients (Dra. Helene A. Haeberle and Dr. Wolfgang A. Krueger, Tubingen. Germany). 13. Acute Respiratory Distress Syndrome and pneumonia (Dr. Jean Chastre, Dr. Charles-Edouard Luyt, Dr. Jean Louis Trouillet, Dr. Alain Combes, Paris, France). 14. Assessment of patients with poor resolution of Hospital Acquired Pneumonia (Dr. Richard G. Wunderink, Dr. Keenan A. Hawkins, Chicago, USA). 15. Approach to Patients with recurrent VAP (Dr. Grant W. Waterer, Perth, Australia; Dr. Diego López. Madrid. Spain). 16. Costs for Hospital-Acquired Pneumonia & Ventilator-Associated Pneumonia (Dr. Andrew F. Shorr and Dr. William L. Jackson, Washington, USA). Index.

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Book SynopsisCancer vaccine development has changed from a small-scale academic enterprise in to an applied science requiring a large, clinical-research infrastructure. Cancer Vaccines and Tumor Immunity will serve a unique role in that it will present as a continuum the basic science discoveries that have moved forward into clinical trials.Table of ContentsContributors. Foreword. Cancer Vaccines and Cancer Immunotherapy. A New Paradigm(Jeffrey Schlom). PART I. INTRODUCTION. Chapter 1. Cancer Vaccines. Progress and Promise (Rimas J. Orentas, Bryon Johnson, and James Hodge). PART II. ADJUVANT THERAPY: ENHANCING THE ENDOGENOUS IMMUNE RESPONSE. Chapter 2. Fully Synthetic Carbohydrate-Based Anti-Tumor Vaccines (Rebecca M. Wilson and Samuel J. Danishefsky). Chapter 3. Bacillus Calmette-Guerin Immunotherapy of Genitourinary Cancer (Donald L. Lamm). Chapter 4. Stimulation of Toll-like Receptor 9 for Enhancing Vaccination (Daniel E. Speiser and Arthur M. Krieg). PART III. ANTIGEN-SPECIFIC THERAPY: NOVEL PRESENTATION OF PEPTIDE AND PROTEIN ANTIGENS. Chapter 5. Polyepitope Vaccines (Corey Smith and Rajiv Khanna). Chapter 6. Antigen-Specific Cancer Immunotherapy: HPV-Associated Cervical Cancer as a Model System (Shaw-Wei D. Tsen, Chien-Fu Hung, and T.-C. Wu). Chapter 7. Poxviral Vectors for Cancer Vaccines: State of the Art (Elizabeth K. Wansley). Chapter 8. Immunotherapeutic Strategies Against Cancer Using Listeria Monocytogenes as a Vector for Tumor Antigens (Nicholas C. Souders, Thorsten Verch and Yvonne Paterson). Chapter 9. Coupling Innate and Adaptive Immunity with Yeast-based Cancer Immunotherapy (Sibyl Munson, Joanne Parker, Tom King, Yingnian Lu, Victoria Kelley, Zhimin Guo, Virginia Borges, and Alex Franzusoff). PART IV. CELL-BASED THERAPY: USING CANCER CELLS AS A MEANS TO INDUCE SPECIFIC TUMOR IMMUNITY. Chapter 10. Allogeneic Whole Cell Vaccines (John Copier and Angus Dalgleish). Chapter 11. Jump-Starting Tumor Immunity with Breast Cancer Therapeutics (Leisha A. Emens). Chapter 12. T-Regulatory Cell Manipulation in Tumor Immunotherapy (Jens Rüter, Brian G. Barnett, Ilona Kryczek, Michael J. Brumlik, Benjamin J. Daniel, George Coukos, Weiping Zou, Tyler J. Curiel). Chapter 13. Tumor Vaccination after Autologous HSCT: What has been Learned from Experimental Models? (Weiqing Jing and Bryon D. Johnson). Chapter 14. Vaccines in the Setting of Hematopoietic Stem Cell Transplantation (Ronald Gress and Claude Sportes). Chapter 15. Intratumor Generation of Vigorous Antitumor Immune Responses (Ping Yu and Yang-Xin Fu). Chapter 16. Cancer Immunotherapy: Untapping the Potential of Co-Stimulatory Molecules Beyond CTLA-4 (Mathew Augustine, and Lieping Chen). PART V. DEFINING EFFECTIVE CLINICAL RESPONSES. Chapter 17. Advances in Immune Monitoring Strategies for Cancer Vaccines and Immunotherapy (Seunghee Kim-Schulze, Moshe Ornstein and Howard L. Kaufman). Chapter 18. Immune Evaluation of Cancer Vaccines (Theresa L. Whiteside). Index.

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Book SynopsisThis is the only reference and textbook of its kind to cover perioperative and supportive care in gynecologic oncology within the framework of evidence-based medicine.Table of ContentsForeword to the Second Edition ix Contributors xi Part One General Principles 1. Introduction 1 Steven A. Vasilev and Scott E. Lentz 2. Evidence-Based Medicine and Decision Support 11 Steven A. Vasilev 3. Vascular Access and Other Invasive Procedures 43 Paul Koonings and Scott E. Lentz 4. Fluids, Electrolytes, and Nutrition 69 Howard Silberman and Matthew Powers Part Two Perioperative Management of Gynecologic Surgery 5. Preoperative Evaluation 145 Devansu Tewari 6. Postoperative Surveillance and Perioperative Prophylaxis 161 Harriet O. Smith and Lejla Delic 7. Perioperative Infections: Prevention and Therapeutic Options 235 Amy Stenson 8. Intraoperative and Perioperative Considerations in Laparoscopy 261 Steven A. Vasilev and Scott E. Lentz Part Three Oncologic Perioperative Decision Making 9. Cervical Carcinoma 299 Fidel A. Valea 10. Endometrial Cancer 329 R. Wendel Naumann 11. Pelvic Masses and Ovarian Carcinoma 361 Margarett C. Ellison 12. Molar Gestation 377 Allison E. Axtell and Steven A. Vasilev 13. Perioperative Issues in the Management of Vulvar Cancer 389 Kathryn F. McGonigle and Maliaka W. Amneus Part Four Complimentary Medicine/Supportive Care 14. Perioperative Psychosocial Considerations 419 Judith McKay and Steven A. Vasilev 15. Pain Management in Gynecologic Oncology 443 Laszlo Z. Galffy and Clayton A. Varga 16. Fertility Preservation in the Gynecologic Cancer Patient 469 Nicole Fleming 17. Perioperative Herbal and Supplement Use 487 Alexander Vasilev and Steven Vasilev 18. End-of-Life Decision Making 509 Scott E. Lentz Index 539

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Book SynopsisThis resource provides an integrated and comprehensive overview ofmodern approaches to drug lead discovery. Each chapter in this bookreviews the theoretical background and application of a keytechnology in drug discovery, complemented by relevant casestudies.Trade Review"The book provides a comprehensive overview of many aspects of the lead generation process . . . The book delivers a good introduction to the process of lead generation for novice researchers. It is also useful for more experienced scientists to update their knowledge and/or to identify some new details." (ChemMedChem, October 2010) "This volume is recommended to chemists and biologists who wish to learn about the practice of high throughput screening and about the concepts involved in making the method a successful route to drug discovery." (Journal of Medicinal Chemistry, 2010)"Each chapter provides a comprehensive overview of one aspect of the lead generation process. To get more indepth knowledge, extensive references including recent publications are given." (ChemMedChem, 2010)Table of ContentsPREFACE. CONTRIBUTORS. 1 Lead Discovery: The Process (William F. Michne). 2 High Throughput Screening Approach to Lead Discovery (Zoran Rankovic, Craig Jamieson, and Richard Morphy). 3 In Silico Screening (Dagmar Stumpfe, Hanna Geppert, and Jürgen Bajorath). 4 Fragment-Based Lead Discovery (Jeffrey S. Albert). 5 Design of Multitarget Ligands (Richard Morphy and Zoran Rankovic). 6 De novo Drug Design (Gisbert Schneider, Markus Hartenfeller, and Ewgenij Proschak). 7 Role of Natural Products in Drug Discovery (Hugo Lachance, Stefan Wetzel, and Herbert Waldmann). 8 Early Screening for ADMET Properties (Dennis A. Smith). 9 Role of Chemistry in Lead Discovery (Roland E. Dolle and Karin Worm). INDEX.

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Book SynopsisThe only resource to thoroughly cover the critical issues of hardware/software design and implementation in a systematic and easily comprehensible manner, PACS and Imaging Informatics addresses the latest in PACS, from the electronic patient record to the full range of topics in digital imaging.Table of ContentsFOREWORD. PREFACE. PREFACE OF THE LAST EDITION. ACKNOWLEDGMENTS. H. K. HUANG SHORT BIOGRAPHY. LIST OF ACRONYMS. 1. Introduction. PART I MEDICAL IMAGING PRINCIPLES. 2. Digital Medical Image Fundamentals. 3. Two-Dimensional Medical Imaging. 4. Three-Dimensional Medical Imaging. 5. Four-Dimensionality, Multimodality, and Fusion of MedicalImaging. 6. Image Compression. PART II PACS FUNDAMENTALS. 7. Picture Archiving and Communication System Components andWorkflow. 8. Communications and Networking. 9. Industrial Standards (HL7 and DICOM) and Integrating theHealthcare Enterprise (IHE). 10. Image Acquisition Gateway. 11. PCS Server and Archive. 12. Display Workstation. 13. Integration of HIS, RIS, PACS, and ePR. PART III PACS OPERATION. 14. PACS Data Management and Web-Based Image Distribution. 15. Telemedicine and Teleradiology. 16. Fault-Tolerant PACS and Enterprise PACS. 17. Image/Data Security. 18. PACS Clinical Implementation, Acceptance, andEvaluation. 19. PACS Clinical Experience, Pitfalls, and Bottlenecks. PART IV PACS- AND DICOM-BASED IMAGING INFORMATICS. 20. DICOM-Based Medical Imaging Informatics. 21. Data Grid for PACS and Medical Imaging Informatics. 22. Multimedia Electronic Patient Record (ePR) System. 23. Multimedia Electronic Patient Record System in RadiationTherapy. 24. Multimedia Electronic Patient Record (ePR) System forImage-Assisted.Spinal Surgery. 25. Computer-Aided Diagnosis (CAD) and Image-Guided DecisionSupport. 26. Integration of Computer-Aided Diagnosis (CAD) with PACS. 27. Location Tracking and Verification System in ClinicalEnvironment. 28. New Directions in PACS and Medical Imaging InformaticsTraining. PACS AND IMAGING INFORMATICS GLOSSARY. INDEX.

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Book SynopsisThe publication of this fourth edition, more than ten years on from the publication of Radiation Therapy Physics third edition, provides a comprehensive and valuable update to the educational offerings in this field. Led by a new team of highly esteemed authors, building on Dr Hendee's tradition, Hendee's Radiation Therapy Physics offers a succinctly written, fully modernised update. Radiation physics has undergone many changes in the past ten years: intensity-modulated radiation therapy (IMRT) has become a routine method of radiation treatment delivery, digital imaging has replaced film-screen imaging for localization and verification, image-guided radiation therapy (IGRT) is frequently used, in many centers proton therapy has become a viable mode of radiation therapy, new approaches have been introduced to radiation therapy quality assurance and safety that focus more on process analysis rather than specific performance testing, and the explosion in patient-anTrade Review"The book is well structured and gives an excellent overview on all practical aspects of modern radiotherapy and the physics involved. The many examples and problems allow for immediate check of the understanding of the text and make it fun to read. The new editors certainly did a very good job in carrying on the tradition of the original book" Physica Medica, Feb 2017. Full review available here "The newly published fourth edition of Hendee’s Radiation Therapy Physics (Authors: Todd Pawlicki, Daniel J. Scanderbeg, George Starkschall) provides an updated overview, analysis and practical guidance of the various aspects of the radiation therapy physics. Published ten years after the publication of the third edition, this book reviews all newly introduced modalities and approaches inRadiation therapy - intensity-modulated radiation therapy (IMRT), image-guided radiation therapy (IGRT), digital imaging, CT simulation, proton therapy, radiation therapy informatics. An important part of the book is the focus on the professional approaches in radiation protection, patient safety, quality assurance, quality improvement and even training for residents. The book is written by experts in the field – all three authors are well known professionals working in the field of Radiation Physics and Radiation Medicine. Throughout this book the reader finds scientific, educational and practical information from the very basics of radiation physics to the latest achievements in the field of Radiation Therapy. Each chapter is well structured, giving a good balance between the theoretical and practical aspects. The appendix is dedicated to solving practical problems and provides professional advice, as well as self-tests......This book is both an excellent reference which will be useful in all medical physics departments and at the same time a perfect guidance material for professionals in related specialties. It continues very well the line set by Prof. William Hendee (past IOMP ExCom member). The Content and Structure of the book are excellent. These are really necessary for a book with such coverage and volume. Thefourth edition of Hendee’s Radiation Therapy Physics is yet another fundamental book that will be very useful reference for various specialists for many yearsahead" - Medical Physics World 2016Table of ContentsPreface to the Fourth Edition, vi Preface to the Third Edition, vii Preface to the Second Edition, viii Preface to the First Edition, ix 1 Atomic Structure and Radioactive Decay, 1 2 Interactions of X Rays and Gamma Rays, 16 3 Interactions of Particulate Radiation with Matter, 29 4 Machines for Producing Radiation, 35 5 Measurement of Ionizing Radiation, 57 6 Calibration of Megavoltage Beams of X Rays and Electrons, 77 7 Central-axis Point Dose Calculations, 96 8 External Beam Dose Calculations, 110 9 External Beam Treatment Planning and Delivery, 123 10 The Basics of Medical Imaging, 146 11 Diagnostic Imaging and Applications to Radiation Therapy, 154 12 Tumor Targeting: Image-guided and Adaptive Radiation Therapy, 170 13 Computer Systems, 182 14 Radiation Oncology Informatics, 197 15 Physics of Proton Radiation Therapy, 204 16 Sources for Implant Therapy and Dose Calculation, 215 17 Brachytherapy Treatment Planning, 231 18 Radiation Protection, 248 19 Quality Assurance, 267 20 Patient Safety and Quality Improvement, 294 Appendix: Answers to Selected Problems, 310 Index, 317

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Book SynopsisClinical oncologists and researchers now have a comprehensive single source of current information on cancer viruses obtained from bench and bedside. This important refernceallows further development of translational approaches for the effective treatment of patients with virus-associated malignancies. The book contains 25 chapters covering basic and clinical aspects of viruses, including HPV, HBV, HCV, polyomaviruses, Kaposi's associated viruses, retroviruses (including HIV-1 associated malignancies), and EBV. Several chapters are devoted to basic science of oncogenic viruses for the study of their pathogenesis, drug development, and employment of viral vectors for vaccine and gene therapy. Clinical materials are embedded within chapters, and there are also complementary, clinically based chapters describing natural courses and treatments.Trade Review"The book is addressed to medical students as well as clinical scientists and students of molecular biology. In a rapidly growing field it is a great advantage to have all this valuable information in one volume." (Journal Tropical Ped, 2012) "I would recommend this book to all interested in the role that viruses play in cancer development, students and experienced researchers alike." (Society for General Microbiology, July 2010)Table of ContentsForeword vii Preface xi Contributors xiii 1 HUMAN PAPILLOMAVIRUS-ASSOCIATED CANCERS 1Rachel A. Katzenellenbogen and Denise A. Galloway 2 MOLECULAR EVENTS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS-INDUCED HUMAN CANCERS 23Amy Baldwin and Karl Münger 3 THE ROLE OF THE HUMAN PAPILLOMAVIRUS E6 ONCOPROTEIN IN MALIGNANT PROGRESSION 57Miranda Thomas, David Pim, and Lawrence Banks 4 JC VIRUS ASSOCIATION WITH BRAIN TUMORS: THE ROLE OF T ANTIGEN AND INSULIN-LIKE GROWTH FACTOR 1 IN DNA REPAIR FIDELITY 89Krzysztof Reiss, Kamel Khalili, and Luis Del Valle 5 INVOLVEMENT OF THE POLYOMAVIRUS, JC VIRUS, IN COLORECTAL CANCER 113C. Richard Boland, Luigi Ricciardiello, and Ajay Goel 6 POSSIBLE ASSOCIATION OF BK VIRUS WITH PROSTATE CANCER 129Michael J. Imperiale and Dweepanita Das 7 ONCOGENIC TRANSFORMATION BY POLYOMAVIRUS LARGE T ANTIGEN 149Abhilasha V. Rathi and James M. Pipas 8 SIMIAN VIRUS 40, HUMAN INFECTIONS, AND CANCER: EMERGING CONCEPTS AND CAUSALITY CONSIDERATIONS 165Janet S. Butel 9 SIMIAN VIRUS 40 AND MESOTHELIOMA 191Natalya Baranova and Michele Carbone 10 MOLECULAR IMMUNOBIOLOGY OF HEPATITIS B-ASSOCIATED VIRAL CANCER 211Timothy M. Block and Anand S. Mehta 11 HEPATITIS B VACCINE AND HEPATOCELLULAR CARCINOMA 225Mei-Hwei Chang and Ding-Shinn Chen 12 PATHOGENESIS OF ACUTE AND CHRONIC HEPATITIS C VIRUS INFECTION 243Mark A. Feitelson, Helena M.G.P.V. Reis, Jingbo Pan, and Bill Sun 13 MOLECULAR MECHANISMS OF HEPATITIS C VIRUS-INDUCED CELLULAR TRANSFORMATION 267Donna Sir and Jing-Hsiung James Ou 14 CLINICAL ASPECTS OF HTLV-1-ASSOCIATED CANCER 279Masao Matsuoka 15 ONCOGENIC POTENTIAL OF THE HTLV-1 TAX PROTEIN 295Susan J. Marriott 16 HIV-1-ASSOCIATED MALIGNANCY: BASIC AND CLINICAL ASPECTS 317Melissa Agsalda and Bruce Shiramizu 17 HIV-RELATED LYMPHOMA 337Giulia De Falco, Cristiana Bellan, Stefano Lazzi, and Lorenzo Leoncini 18 BIOLOGY AND EPIDEMIOLOGY OF HHV-8 351Veenu Minhas and Charles Wood 19 THE ROLE OF KSHV IN PATHOGENESIS OF KAPOSI’S SARCOMA 377Gary S. Hayward, Donald J. Alcendor, and Ravit Arav-Boger 20 MOLECULAR PATHOBIOLOGY OF EBV INFECTION 409Joseph S. Pagano 21 EPSTEIN–BARR VIRUS AS A PATHOGEN 425Wasim A. Dar and Bill Sugden Index 453

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Book SynopsisThis atlas provides a comprehensive outline of all but the very rarest salivary gland diseases, detailing the most common benign and malignant tumors with their radiological, cytopathological, and histological features. The differential diagnosis of each tumor is presented with essential tips on the use of fine needle aspiration (FNA) and making a correct diagnosis. Three separate chapters are dedicated to: introduction to salivary gland FNA with emphasis on the technique used to perform the aspiration; the surgical anatomy of these glands; and the various radiological characteristics of these lesions, including primarily CT scans and MRI studies.Table of ContentsPreface vii Contributors ix 1 Introduction to Salivary Gland Lesions Cytology 1Mousa A. Al-Abbadi, MD, FIAC 2 Surgery for Salivary Gland Lesions: A Surgeon’s Perspective 13Ozlem E. Tulunay-Ugur, MD 3 Radiological Investigation of Salivary Gland Lesions 23Imad Zak, MD 4 Infectious and Inflammatory Diseases of Salivary Glands 43Wael N. Zakaria, MD, Isam A. Eltoum, MD, MBA, FIAC, Mousa A. Al-Abbadi, MD, FIAC 5 Pleomorphic Adenoma 57Jining Feng, MD, PhD, Mousa A. Al-Abbadi, MD, FIAC 6 Warthin’s Tumor 69Mousa A. Al-Abbadi, MD, FIAC 7 Mucoepidermoid Carcinoma 77Ruba Halloush, MD 8 Carcinoma Ex Pleomorphic Adenoma 87Husain A. Saleh, MD, FIAC, MBA 9 Acinic Cell Carcinoma 97Eyas M. Hattab, MD, Harvey M. Cramer, MD 10 Basaloid Salivary Gland Tumor 109Jerzy Klijanienko, MD, PhD, MIAC, Isam A. Eltoum, MD, MBA, FIAC 11 Adenoid Cystic Carcinoma 131Husain A. Saleh, MD, FIAC, MBA 12 Oncocytoma 145Jay K. Wasman, MD, Fadi W. Abdul-Karim, MD 13 Myoepithelioma and Related Lesions 157Pamela Papas, MD, Momin T. Siddiqui, MD 14 Polymorphous Low-Grade Carcinoma 175Jerzy Klijanienko, MD, PhD, MIAC, Mousa A. Al-Abbadi, MD, FIAC 15 Salivary Duct Carcinoma 181Jerzy Klijanienko, MD, PhD, MIAC, Mousa A. Al-Abbadi, MD, FIAC 16 Salivary Gland Lymphomas 187Mohammad Abuel-Haija, MD, Magdalena Czader, MD, PhD 17 Metastases and Rare Primary Neoplasms of Salivary Glands 215Mousa A. Al-Abbadi, MD, FIAC Index 243

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Book SynopsisTrade ReviewHendee’s Physics of Medical Imaging, 5th Edition is written with clear and focused academic language…and will be very useful both for students and lecturers on the subject. Congratulations to both authors for the excellent textbook. - Slavik Tabakov, King’s College London, UK, Immediate Past President IOMP (International Organization of Medical Physics)Table of ContentsForeword ix Commentary by William Hendee xi Clarification and Acknowledgment xiii Introduction: The Role of Imaging in Medicine xv 1 Physics of Radiation and Matter 1 2 Anatomy, Physiology, and Pathology in Imaging 55 3 Imaging Science 89 4 Radiobiology, Dosimetry, and Protection 143 5 Imaging Operation and Infrastructure 181 6 Projection X-ray Imaging 217 7 Volumetric X-ray Imaging 243 8 Nuclear Medicine 271 9 Ultrasonography 305 10 Magnetic Resonance Imaging 339 Index 453

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Book SynopsisA thorough updating of the best-selling, vital reference and textbook on melanocytic proliferations PRAISE FOR THE FIRST EDITION: Well-written and entertaining Modern Pathology An extremely helpful guide for the practicing dermatopathologist or general pathologist Archives of Pathology and Laboratory Medicine An incredibly relevant clinical-histopathologic text Doody's Melanocytic proliferations comprise a large number of pigmented lesions of the skin and muscosa. Of these, melanoma is of particular interest to clinicians and their patients. The rising number of incidences of melanoma has led to increased interest in the disease from diagnostic, management, and basic science perspectives. The Melanocytic Proliferations: A Comprehensive Textbook of Pigmented Lesions is the most complete single-source treatment of the subject availablethoroughly updated to reTable of ContentsDedication, vii Preface, viii Disclosure, ix About the Companion Website, x 1 An Approach to the Clinical Diagnosis of Melanoma, Its Precursors, and Its Clinical Mimics, 1 2 Freckles and Lentigines, 44 3 Benign Acquired Nevi, 65 4 Dermal Dendritic Melanocytic Proliferations/Dermal Melanocytoses, 85 5 Spitz Nevus, 107 6 Combined Nevus, Deep Penetrating Nevus, Plexiform Spindle Cell Nevus, and Borderline Tumors of the Deep Penetrating Nevus Variant, 164 7 Recurrent Melanocytic Nevus, 175 8 Congenital Nevi, 187 9 Dysplastic Melanocytic Nevi, De Novo Intradermal Epithelioid and Lentiginous Melanocytic Dysplasias, and Nevi at Specific Anatomic Sites, 201 10 Melanoma, 254 11 Conjunctival Melanocytic Proliferations, 365 12 Use of Adjunctive Immunoperoxidase, Molecular, and Ultrastructural Studies in the Diagnosis of Melanocytic Proliferations, 380 13 Biology of Melanoma, 412 14 Borderline Melanocytic Proliferation, 443 15 Dermatoscopic Diagnosis of Melanoma, 467 16 Reflectance Confocal Microscopy, 474 17 Therapy of Melanoma, 488 Index, 510

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Book SynopsisThis is the first book to focus on frequent and frequently disabling side effects involving the skin, hair, and nails in cancer patients.Table of ContentsList of Contributors, vii Preface, x Section 1 Dermatology and Oncology 1 Epidemiology and Burden of Disease, 3Beth N. McLellan, Devika Patel and Mario E. Lacouture 2 The History of Supportive Oncodermatology, 17Yevgeniy Balagula, Steven T. Rosen and Mario E. Lacouture 3 Structure and Function of the Integumentary System and the Dermatology Lexicon, 24Emmy Graber and Amit Garg 4 Types of Dermatologic Reactions, 33Raed O. Alhusayen, Sandra R. Knowles and Neil H. Shear 5 Grading Dermatologic Adverse Events in Clinical Trials Using CTCAE v4.0, 47Alice Chen, Asha Acharya and Ann Setser 6 Psychosocial Issues in Oncology: Clinical Management of Psychosocial Distress, Health-Related Quality of Life, and Special Considerations in Dermatologic Oncology, 60Lynne I. Wagner and David Cella 7 Dermatopathology, 69Molly A. Hinshaw and James L. Troy Section 2 Cancer-Related Dermatologic Disorders 8 Paraneoplastic, Inherited Cancer Syndrome, and Environmental Carcinogen-Related Dermatoses, 77Cindy England Owen and Jeffrey P. Callen Section 3 Dermatologic Conditions During Cancer Therapy 9 Oral Mucosal Complications of Cancer Therapy, 89Stephen T. Sonis 10 Hair Disorders Associated with Anticancer Agents, 100Caroline Yeager and Elise A. Olsen 11 Nail Abnormalities in Oncology Practice, 115Robert Baran, Bernard Fouilloux and Caroline Robert 12 Pruritus, 122Tejesh Patel and Gil Yosipovitch 13 Management Options for Hot Flashes in Cancer Patients, 131Amanda R. Moraska and Charles L. Loprinzi Section 4 Skin Toxicities to Chemotherapy 14 Alkylating Agents, 147Elisabeth Livingstone, Lisa Zimmer, Larissa Leister and Dirk Schadendorf 15 Antimetabolite Reactions, 160Emily Y. Chu and Heidi H. Kong 16 Topoisomerase-Interacting Agents, 170Tomas Skacel, Roger von Moos and Reinhard Dummer 17 Epidermal Growth Factor Receptor Inhibitor Reactions, 184Yevgeniy Balagula and Mario E. Lacouture 18 Small Molecule Multikinase Inhibitors, 196Caroline Robert, Vincent Sibaud and Christine Mateus 19 Antimicrotubule Agents, 208Claus Garbe 20 Histone Deacetylase Inhibitors, Proteasome Inhibitors, Demethylating Agents, Arsenicals, and Retinoids, 215Najla Al-Dawsari, Shannon C. Trotter and Francine Foss 21 Miscellaneous Reactions, 224Katharina C. Kaehler, Christine B. Boers-Doets, Mario E. Lacouture and Axel Hauschild 22 Skin Toxicities due to Biotherapy, 233Kathryn T. Ciccolini, Katharina C. Kaehler, Mario E. Lacouture and Axel Hauschild 23 Monoclonal Antibodies, 241Caroline Robert 24 Endocrine Agents, 248Katherine Szyfelbein Masterpol, Maura Dickler and Mario E. Lacouture 25 Agents for the Management of Hematologic Reactions, 257Mee-young Lee and Caroline C. Kim 26 Radiation-Induced Skin Reactions, 264Rebecca K.S. Wong and Zahra Kassam 27 Hematopoietic Stem Cell Transplantation and Graft Versus Host Disease, 281Stephanie W. Hu and Jonathan Cotliar 28 Extravasation Reactions, 295Seppo W. Langer 29 Topical Anticancer Therapies, 301Patricia L. Myskowski 30 Life-threatening (Serious) Dermatologic Adverse Events, 310Milan J. Anadkat 31 Dermatologic Infections, 319Yevgeniy Balagula, Mario E. Lacouture and James I. Ito Section 5 Late Cutaneous Events from Cancer Treatment 32 Late Dermatologic Conditions, 339Jennifer Nam Choi Section 6 Dermatologic Practice in Oncology 33 Management Algorithms for Dermatologic Adverse Events, 367Alyx Rosen, Iris Amitay-Laish and Mario E. Lacouture 34 Dermatologic Therapeutics and Formulations, 384Judy H. Borovicka, Jennifer R.S. Gordon, Ann Cameron Haley, Nicole E. Larsen and Dennis P. West 35 Dermatologic Techniques and Procedures, 401Robert Eilers Jr., Kishwer S. Nehal and Erica H. Lee 36 Appearance-Related Concerns in the Cancer Patient, 410Amy J. Derick Index, 417

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Book SynopsisLabor and Delivery Care: A Practical Guide supports and reinforces the acquisition of the practical obstetric skills needed for aiding a successful birth. Beginning with the most important element of successful labor care, communicating with the patient, the authors guide you through normal delivery routines and examination techniques. They then address the best approaches to the full range of challenges that can arise during labor and delivery. Throughout, the 15 chapters provide concise practical guidance with: algorithmic decision trees clinical management tips detailed drawings Labor and Delivery Care: A Practical Guide provides a thorough tour-de-force of the practical obstetric skills needed for best and safest practice based on clinical experience and evidence.Trade Review“Labor and Delivery Care: A Practical Guide provides a thorough tour-de-force of the practical obstetric skills needed for best and safest practice based on clinical experience and evidence.” (Kingbook73's Medical Ebook and Video Collection, 10 November 2014)Table of ContentsPreface, vii How to Use This Book, xi 1 Communicating Effectively With Your Patient, 1 2 Examining Your Patient, 13 3 Normal Labor and Delivery, 32 4 Evaluating the Pelvis, 51 5 Diagnosing and Treating Dysfunctional Labor, 81 6 Managing the Third Stage, 111 7 Dealing with Malpositions and Defl exed Attitudes, 128 8 Managing Breech Presentation and Transverse Lie, 151 9 Avoiding and Managing Birth Canal Trauma, 182 10 Inducing Labor, 204 11 Cesarean Delivery, 227 12 Delivering Twins, 250 13 Managing Shoulder Dystocia, 270 14 Using Forceps and the Vacuum Extractor, 290 15 Obstetric Case Studies, 313 Answers to Obstetric Case Studies, 339 Glossary, 355 Index, 383

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Book SynopsisThis brand new, fully updated Fourth Edition of this best-selling PACES revision guide is thoroughly reviewed by PACES candidates to ensure complete coverage of Station 2 - History-taking Skills, and Station 4 - Communication Skills and Ethics.Table of ContentsPreface ix Introduction xiii Section D: History-Taking Skills 1 Station 2, History-Taking Skills 7 1 Abdominal swelling 8 2 Ankle swelling 10 3 Asymptomatic hypertension 13 4 Back pain 16 5 Breathlessness 19 6 Burning of the feet 23 7 Chest pain 26 8 Cold and painful fingers 28 9 Collapse? cause 30 10 Confusion 32 11 Cough 35 12 Diabetic feet 37 13 Difficulty in walking 40 14 Dizziness and feeling faint 43 15 Double vision 45 16 Dysphagia 48 17 Epigastric pain and nausea 50 18 Facial swelling 52 19 Funny turns 55 20 Haemoptysis 58 21 Headache 60 22 Hoarse voice 63 23 Hypercalcaemia 65 24 Hyperlipidaemia 67 25 Jaundice 70 26 Joint pains 73 27 Loin pain 76 28 Loss of weight 78 29 Lower gastrointestinal haemorrhage 80 30 Macrocytic anaemia 82 31 Neck lump 85 32 Painful shins 87 33 Painful shoulders 89 34 Palpitations 91 35 Personality change 93 36 Pins and needles 96 37 Polyuria 98 38 Pruritus 100 39 Purpuric rash 102 40 Pyrexia 104 41 Renal colic and haematuria 107 42 Tiredness 109 43 Tremor 112 44 Visual disturbances 114 45 Vomiting 117 46 Vomiting and forgetfulness 120 47 Weakness of the right arm 123 48 Weight gain 126 49 Weight loss and chronic diarrhoea 129 50 Wheeze 131 Section E: Communication Skills and Ethics 135 Station 4, Communication Skills and Ethics 145 Category 1: Informed Consent 1 Consent for a lumbar puncture 147 2 Consent for oesophagogastroduodenoscopy (OGD) 150 3 Emergency surgery under principles of ‘best interests’ 154 4 A competent patient’s refusal of treatment 157 Category 2: Diagnoses and Management Advice 5 Obesity management 160 6 Side-effects of cardiac medication 163 7 Presentation of a first seizure 166 8 Rheumatoid arthritis 169 9 Valvular heart disease in a young woman 172 10 Air travel with chronic obstructive pulmonary disease 175 11 Polypharmacy 178 12 Blood transfusion 181 13 Hormone replacement therapy 183 14 Lifestyle adjustments after a myocardial infarction 186 15 Smoking cessation 189 16 Starting insulin therapy 192 17 Refusal of analgesia 194 Category 3: General Clinical Issues 18 Human immunodeficiency virus testing 196 19 Communication of a human immunodeficiency virus-positive result 200 20 New diagnosis of tuberculosis 204 21 Non-compliance with anti-tuberculous treatment 208 22 Multidrug-resistant tuberculosis 211 23 ‘Hospital superbug’ 1 (Clostridium difficile) 215 24 ‘Hospital superbug’ 2 (methicillin-resistant Staphylococcus aureus) 219 25 Assessing suicide risk 223 26 Genetic counselling 226 27 Fitness for anaesthesia/surgery 230 28 Screening for prostate cancer 232 Category 4: Breaking Bad News 29 Malignancy in a young patient 235 30 A chronic illness 238 Category 5: Ethical and Legal Issues 31 A patient with a functional illness 240 32 Brainstem death testing and organ transplantation 243 33 Hospital postmortem 248 34 Coroner’s postmortem 253 35 Do not attempt resuscitation decisions 257 36 Withholding information from patients 262 37 Maintaining patient confidentiality 266 38 Advance care decisions 270 39 Healthcare decisions for a patient who lacks mental capacity 274 40 Care of the vulnerable adult 278 41 Blood transfusion for a Jehovah’s Witness 282 42 Eligibility for major surgery 285 43 Postponement of an investigation 287 44 Clinical error in drug administration 289 45 Fitness to drive 292 46 Limits of treatment in end-stage disease 295 47 Withdrawing treatment 298 48 Enrolling a patient in a clinical trial 301 49 Industrial Injuries Disablement Benefit 304 50 Internet therapy 306 51 Unrelated live donor transplant 309 Category 6: Dealing with Difficult Patients/Relatives 52 A patient desperate for a diagnosis 311 53 A missed tumour 315 54 An unhappy inpatient 319 55 Delay in investigation 322 56 A patient wanting to self-discharge 324 Category 7: Professional Issues and Communication with Colleagues 57 Major incident exercise 327 58 A struggling team of doctors 330 59 A colleague with hepatitis B infection 334 60 A colleague with a needlestick injury 337 61 The improper doctor 340 62 The incompetent doctor 343 63 The sick doctor 345 64 Consent for medical examination 347 65 Submitting an audit project 350 66 Treating a prisoner 353 67 A violent and abusive patient 355 68 Withdrawing treatment in intensive care 357 Section F: Experiences, Anecdotes, Tips, Quotations 359 Full PACES experiences in the first person (since2009) 367 Full PACES experiences in the first person (before2009) 389 Additional Station 2 experiences 427 Additional Station 4 experiences 431 Invigilators’ diaries – Stations 2 and 4 435 Some anecdotes from our most recent surveys 435 Experiences 437 The power and range of the candidate’s observations 439 The candidate’s examination technique 441 The clinical competence of the candidate 443 Common errors 444 Look first 444 Double pathology 445 Tell them of the expert that told you 445 Apologies accepted 445 ‘Even though I didn’t mean to say it – I did’ 446 Invigilator’s diaries 446 Fly on the wall – complete accounts 448 Ungentlemanly clinical methods 452 Miscellaneous ‘pass’ experiences 452 You never know you’ve failed until the list is published 464 Survivors of the storm 466 Some ‘fail’ experiences 470 Downward spirals 475 Anecdotes 477 Some anecdotes in the first person 480 Miscellaneous 483 Useful tips 483 Quotations 484 Adopt good bedside manners 485 Practise clinical examination and presentation 485 Get it right 486 Listen, obey and do not stray 486 One wrong does not make one fail 487 If you say less they want more 487 Humility is more persuasive than self-righteousness 487 Keep cool: agitation generates aggression 488 Simple explanations raise simple questions 488 Think straight, look smart and speak convincingly 488 You have seen it all before 489 Use your eyes first and most 489 Doing and forgetting 489 Examiners are different 489 Additional comments and quotes from candidates 490 Appendices 491 1 Website links 493 2 Abbreviations 495 Index 497

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Book SynopsisFollowing the easy-to-use at a Glance format, this brand new title is illustrated throughout with over 60 full-page color illustrations and employs a symptoms-based approach that mirrors the general practice curriculum.Trade Review“A comprehensive guide on history taking, diagnosis and treatment in primary care, useful for written and clinical examinations alike. In particular, the use of high yield schematics throughout - from contraceptive methods and ear and eye symptoms, to the acute abdomen and gynaecological cancer epidemiology - differentiates this text from the rest." (Mobolaji O. Ajekigbe, Imperial College London) “This is a valuable book for young clinicians and students of all disciplines. It is intuitive and provides much teaching material for patients.” (Doody’s) “It will help you develop an understanding of the nature and structure of primary care.” (Student BMA News) “I think it is a fantastic book. I will be recommending it to medical students and other GP registrars. It is a lovely summary of general practice. The authors are obviously very experienced and have managed to distil the real ‘need to know’ facts in a highly reader friendly and engaging way. I would recommend every practice should have a copy of this text. Medical students will find it really useful for exam revision and not just during a GP placement. It’s a really reader-friendly, clear book. It does not scrimp on the medical facts or lose anything by being so slim and lightweight. I think it is priced perfectly for its intended market. The diagrams and illustrations are particularly good and relevant: it’s an excellent revision text for students. It is very difficult to pick out any weaknesses based on its intended audience. I was thoroughly impressed with this book. I though from the style it was going to be a little too basic but it certainly is not. Particularly noteworthy are the illustrations which are highly relevant and clear. The inclusion of photographs makes this text stand out from other similar texts on the market. A far more engaging and informative read than other stodgy textbooks on the same topic. I would have no hesitation in recommending this to medical and GP registrars.” (2013 BMA Medical Book Awards)Table of ContentsContributors 6 Preface 7 Acknowledgements 8 Abbreviations 9 Introduction: how to make the most of your GP attachment 11 Part 1 The essence of general practice 1 The 10-minute consultation: taking a history 12 2 The 10-minute consultation: managing your patient 14 3 Continuity of care and the primary healthcare team 16 4 Why do patients consult? 18 5 Preventive medicine 20 6 Significant event analysis, audit and research 22 7 Communication between primary and secondary care 24 8 Principles of good prescribing in primary care 26 9 Prescribing in children and the elderly 28 10 Law and ethics 30 11 Child abuse, domestic violence and elder abuse 32 Part 2 Common presentations in general practice Child health 12 The febrile child 34 13 Cough and wheeze 36 14 Asthma 37 15 Abdominal problems 38 16 Common behaviour problems 40 17 Childhood rashes 42 18 Child health promotion 44 19 Musculoskeletal problems in children 46 Sexual health 20 Common sexual problems 49 21 Sexually transmitted infections and HIV 52 22 Contraception 54 23 Subfertility 56 Women’s health 24 Termination of pregnancy 58 25 Menstrual disorders 60 26 The menopause 62 27 Common gynaecological cancers 63 28 Breast problems 64 The pregnant woman 29 Antenatal care 66 30 Bleeding and pain in pregnancy 68 31 Other pregnancy problems 70 Care of the elderly 32 Acute confusional state and dementia 72 33 Fits, faints, falls and funny turns 74 Cardiovascular problems 34 Chest pain 76 35 Stroke 78 36 Peripheral vascular disease and leg ulcers 79 37 Preventing cardiovascular disease 80 Respiratory problems 38 Breathing diffi culties 82 39 Cough, smoking and lung cancer 84 40 Asthma and chronic obstructive pulmonary disease 86 Endocrine problems 41 Diabetes 88 42 Thyroid disease 90 Gastrointestinal problems 43 Acute diarrhoea and vomiting in adults 92 44 Dyspepsia and upper gastrointestinal symptoms 94 45 Lower gastrointestinal symptoms 96 46 The acute abdomen 98 Musculoskeletal problems 47 Back pain 100 48 Hip and lower limb 102 49 Neck and upper limb 104 50 Inflammatory arthritis, rheumatism and osteoarthritis 106 Eyes and ENT 51 Upper respiratory tract infection (including sore throat) 108 52 Ear symptoms 110 53 The red eye 112 54 Loss of vision and other visual symptoms 114 Dermatology 55 Eczema, psoriasis and skin tumours 116 56 Other common skin problems 118 Mental health 57 Depression 120 58 Anxiety, stress and panic disorder 122 59 Alcohol and drug misuse 124 60 Eating disorders 126 61 Psychosis and severe mental illness 128 Other common conditions 62 Headache 130 63 Tiredness and anaemia 132 64 Insomnia 134 65 Allergy and hay fever 136 66 Urinary tract disorders 138 67 Chronic pain 140 Further reading and resources 142 Index 146

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Book SynopsisAs haemophilia is a life-long condition, continuing supervision by a group of medical personnel is required. In many countries this is provided by comprehensive care haemophilia centres where staff of all specialities concerned with treatment- haematologists, paediatricians, nurses, physiotherapists, orthopaedic surgeons - have specialized knowledge. This new book is a definitive resource on the current aspects and issues around haemophilia. Complications of haemophilia care are well covered in chapters on inhibitors, and musculoskeletal problems, as are all the latest developments in the field of haemophilia.Table of ContentsList of Contributors. Preface. Part 1: INTRODUCTION. 1 History of Hemophilia (Caroline Cromwell and Louis Aledort). 2 Hemophilia Care in the Modern World (Christine A. Lee). 3 Comprehensive Care Model in Hemophilia (Prasad Mathew). Part 2: GENERAL TOPICS. 4 When Should We Switch From On-Demand to Prophylaxis Regimen? (José A. Aznar, Andres Moret, Lydia Abad-Franch, Ana Rosa Cid, Saturnino Haya and Felipe Querol). 5 Prophylaxis in Children (M. Manco-Johnson). 6 Prophylaxis in Adults with Hemophilia (Victor Jiménez -Yuste, Emérito-Carlos Rodríguez-Merchán, Maria-Teresa Alvarez-Román, Monica Martín –Salces). 7 The Economics of Prophylaxis: Does Prophylaxis with Clotting Factor Represent Value for Money? (Alec Miners). 8 The Transition of Care for the Young Adult Hemophilia Patient (Pia Petrini). 9 Perinatal Clinical Care and Molecular Diagnosis in Hemophilia (Carmen Altisent and Francisco Vidal). 10 Managing the Mature Person with Hemophilia (Savita Rangarajan and Thynn Thynn Yee). 11 Quality of Life in Hemophilia (Eduardo Remor). Part 3: INHIBITORS. 12 Immunology of Inhibitor Development (Birgit M Reipert, Christoph J Hofbauer, Katharina N Steinitz, Hans-Peter Schwarz, FM Horling). 13 Epidemiology of Inhibitors (Johanna G. Van der Bom) 14 Early Tolerisation to Minimise Inhibitors in PUPS with Hemophilia A (Günter Auerswald and Karin Kurnik). 15 Prediction of Inhibitors in Severe Hemophilia (H. Marijke van den Berg and Kathelijn Fischer). 16 Genetic basis for Inhibitor Development (Johannes Oldenburg and Anna Pavlova). 17 Non-Genetic Risk Factors for Inhibitor Development (Lisa N. Boggio and Mindy L. Simpson). Part 4: INHIBITOR TREATMENT. 18 Immune Tolerance Induction Programmes (Jan Blatny and Prasad Mathew). 19 Prophylaxis in Hemophilia A Patients with Inhibitors (Leonard A. Valentino and Guy Young). 20 Treatment of Bleeding in FVIII Inhibitor Patients (Paul Giangrande and Jerome Teitel). 21 Discordancy of By-Passing Therapy (Jan Astermark). Part 5: JOINT HEALTH AND DISEASE. 22 Experimental Studies on Hemarthrosis, Synovitis and Arthropathy (Leonard A. Valentino and Narine Hakobyan). 23 Assessment of Joint Involvement in Hemophilia (Erik Berntorp). 24 Imaging of the Hemophilic Joint (Carmen Martín-Hervásand Emérito-Carlos Rodríguez-Merchán). 25 Initial and Advanced Stages of Hemophilic Arthropathy, and Other Musculo-Skeletal Problems: the Role of Orthopedic Surgery (Emérito-Carlos Rodríguez-Merchán, VictorJiménez -Yuste and Nicholas J. Goddard). 26 Perioperative Thromboprophylaxis for Persons with Hemophilia Undergoing Orthopaedic Surgery (Gerry Dolan, Donna M. Dimichele and Emérito-Carlos Rodríguez-Merchán). Part 6: NEW DEVELOPMENTS. 27 New Technologies for the Pharmacokinetic Improvement of Coagulation Factor Proteins (Leonard A. Valentino). 28 Current and Future Approaches to Gene Therapy in Patients with Hemophilia (Maria-Teresa Alvarez- Román, Monica Martín-Salces, Victor Jiménez -Yuste and Emérito-Carlos Rodríguez-Merchán). 29 New Developments in Hemophilic Arthropathy (Emérito-Carlos Rodríguez-Merchán and Leonard A. Valentino). 30 Physiotherapy Evaluation and Intervention in the Acute Hemarthrosis: Challenging the Paradigm (Nichan Zourikian and Angela L. Forsyth). 31 Laboratory Assays to Predict Response to Bypassing Agents (Benny Sørensen and Claude Negrier). 32 Combination/Sequential Use of Bypassing Agents (Alessandro Gringeri). Index.

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Book SynopsisEpilepsy requires careful management and monitoring through a woman s life Epilepsy is a complex disease. The hormonal changes women experience, both day-to-day menstrual fluctuations and the longer waxes and wanings of a reproductive lifetime, make the management of epilepsy even more complicated.Table of ContentsPreface, vii Contributors, ix 1 Gender Difference in Epidemiology and Comorbidities of Epilepsy, 1 Ettore Beghi and Massimiliano Beghi 2 The Social and Psychological Impacts of Epilepsy, 11 Sanjeev V. Thomas and Aparna Nair 3 Neurosteroid influences on neuronal excitability: The menstrual cycle and catamenial epilepsy as dynamic models, 23 Doodipala Samba Reddy 4 Catamenial Epilepsy, 41 Erik Taubøll, Line S. Røste and Sigrid Svalheim 5 Impact of Epilepsy and AEDs on Reproductive Health, 53 Gerhard Luef 6 Contraception and Epilepsy, 64 Anne R. Davis and Kathleen M. Morrell 7 Diagnostic Challenges with Seizures in Pregnancy, 75 Sanjeev V. Thomas 8 Seizure Control During Pregnancy, 91 Anne Sabers 9 Effect of Pregnancy on AED Kinetics, 101 Peter B. Forgacs and Page B. Pennell 10 Fetal and Maternal Risks with Seizures, 115 Vilho K. Hiilesmaa and Kari A. Teramo 11 Obstetrical Outcome and Complications of Pregnancy, 128 Ingrid Borthen and Nils Erik Gilhus 12 Mechanisms of Teratogenic Effects of AEDs, 136 Lynsey E. Bruce, Ana M. Palacios, Bogdan J. Wlodarczyk and Richard H. Finnell 13 Major Congenital Malformations in Offspring of Women with Epilepsy, 148 Dina Battino and Torbjörn Tomson 14 Fetal AED Syndromes, 164 Usha Kini 15 Postnatal Cognitive Development, 170 Evan R. Gedzelman and Kimford J. Meador 16 M anagement of the Postpartum Period and Lactation, 184 Autumn M. Klein 17 M anagement of Epilepsy and Pregnancy, 196 Sanjeev V. Thomas, Torbjörn Tomson and Cynthia L. Harden 18 Perimenopause and Menopause, 200 Cynthia L. Harden 19 Bone Health, 205 Alison M. Pack Index, 211

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Book SynopsisSuitable for neurologists and cardiologists, this book considers various topics regarding stroke, including bedside evaluation of the acute stroke patient; neurovascular imaging of the acute stroke patient; treatment of acute ischemic stroke; treatment of hemorrhagic stroke; and prevention and management of post-stroke complications.Trade Review“It was a pleasure to review this book, particularly after going through many stroke books as a recent trainee, and I found its scope and content refreshing. I will certainly pass this along to other trainees and I recommend it highly.” (Doody’s, 30 August 2013)Table of ContentsContributors vi Series Foreword viii Preface ix Chapter 1Bedside Evaluation of the Acute Stroke Patient 1Bryan J. Eckerle and Andrew M. Southerland Chapter 2Neurovascular Imaging of the Acute Stroke Patient 16Karthik Arcot, Jason M. Johnson, Michael H. Lev, and Albert J. Yoo Chapter 3Treatment of Acute Ischemic Stroke 37Nader Antonios and Scott Silliman Chapter 4Diagnosis of Stroke Mechanisms and Secondary Prevention 55Kelly D. Flemming Chapter 5Treatment of Hemorrhagic Stroke 78Andreas H. Kramer Chapter 6Prevention and Management of Poststroke Complications 103Raid G. Ossi Chapter 7Poststroke Recovery 119Samir R. Belagaje and Andrew J. Butler Chapter 8Telemedicine Networks and Remote Evaluation of the Acute Stroke Patient 137Bart M. Demaerschalk Chapter 9Appendix: Practical Clinical Stroke Scales 153Kevin M. Barrett and James F. Meschia Index 159 Color plates are found facing page 22

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Book SynopsisABC of Cancer Care is a practical primary care guide to help health professionals better inform their patients, manage and recognize the common complications of cancers and their treatment, and understand the rationale and implications of decisions made in secondary and tertiary care.Trade Review“I have recently been given a donation of £150 to be used to benefit cancer services. I now know what to do with it. I am going to buy a copy of this book for each of our site-specific cancer teams in the hospital.” (Cancer Nursing Practice, 1 December 2013) Table of ContentsList of Contributors vii Preface xi Acknowledgements xiii 1 Multidisciplinary Care 1Richard Simcock 2 Cancer Imaging 5Guy Burkill and Adrian K.P. Lim 3 Surgery 10Daniel Richard Leff and Richard Simcock 4 Surgery for Metastatic Disease 15Timothy W.R. Briggs Elizabeth J. Gillott Lewis W. Thorne and Long R. Jiao 5 Chemotherapy 20Catherine Harper-Wynne and Catherine M. Kelly 6 Toxicities of Chemotherapy 26Sacha Jon Howell Alison Jones and Colin R. James 7 Radiotherapy 30Alastair Thomson and Mark Beresford 8 Toxicities of Radiotherapy 34Russell Burcombe Jonathan Hicks and Richard Simcock 9 Endocrine Therapy 39Carlo Palmieri Matthew Flook and Duncan C. Gilbert 10 Biological and Targeted Therapies 44Ruth E. Board Jennifer W. Pang Carlo Palmieri and Suzy Cleator 11 Trials in Cancer Care 50Evandro de Azambuja David Cameron and Janet E. Brown 12 Oncological Emergencies 55Thomas E. Newsom-Davis and Mohammed Rizwanullah 13 Cancer in the Elderly 61Alistair Ring and Juliet E. Wright 14 Nutrition 64Mhairi Donald 15 Complementary and Alternative Medicine in Cancer Patients 69Richard Simcock and Sarah Cavilla 16 Specialist Nursing Care 74Clare Sullivan Beverley Longhurst Amelia Cook Elizabeth Bowman and Jean Rodell 17 Cancer Survivorship 78Esther Bird Amy Guppy and Carlo Palmieri Index 83

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Book SynopsisThe guide to effective practice management of precancerous lesions in cervix and lower genital tract. This third edition contains in-depth examination of the different modalities that contribute to the safe and scientific management of precancerous lesions in the female genital tract.Table of ContentsPreface to the Third Edition ix Preface to the First Edition x Acknowledgements xi 1 The Histopathology of Lower Genital Tract Neoplasia 1 1.1 Introduction 1 1.2 Terminology 1 1.3 Histopathologic features of cervical intraepithelial neoplasia or squamous intraepithelial lesion 3 1.4 Cervical glandular intraepithelial neoplasia and adenocarcinoma in situ 6 1.5 Early invasive carcinoma 7 1.6 Vaginal intraepithelial neoplasia 11 1.7 Vulval precancer 11 1.8 Related topics 12 1.9 Further reading 13 2 Human Papillomaviruses in the Pathogenesis of Lower Genital Tract Neoplasia 14 2.1 Introduction 14 2.2 Characteristics of human papillomaviruses 14 2.3 Manifestations of genital human papillomavirus infections 15 2.4 Prevalence of genital human papillomavirus infections 18 2.5 Transmission of genital human papillomavirus infections 19 2.6 Risk factors for genital human papillomavirus infections 19 2.7 Natural history of cervical human papillomavirus infections 19 2.8 Molecular pathways of human papillomavirus oncogenesis 19 2.9 The effect of human papillomavirus/host cell interaction: a prerequisite for neoplasia 21 2.10 The role of oncogenic human papillomavirus detection in the prevention of lower genital tract precancer 22 2.11 Further reading 23 3 Examination for Cervical Precancer: Use of colposcopy 24 3.1 Introduction 24 3.2 Tissue basis for colposcopy 24 3.3 The colposcopic examination 25 3.4 Video colposcopy 31 3.5 Image and electronic data management 31 3.6 Further reading 32 4 Colposcopy of the Normal Cervix: A prerequisite to establishing the diagnosis of cervical precancer 33 4.1 Introduction 33 4.2 Cervical epithelium: natural history 33 4.3 Cervical epithelium: topography 34 4.4 Cervical epithelium: colposcopic appearances 35 4.5 Squamous metaplastic epithelium 38 4.6 Colposcopy of the adolescent cervix 44 4.7 Cervical epithelium during pregnancy and puerperium 46 4.8 The effect of vaginal delivery on the cervical epithelium 48 4.9 The cervical epithelium during the menopause 50 4.10 The oral contraceptives and their effect on the cervix 52 4.11 The congenital transformation zone 53 4.12 Further reading 58 5 Cytology and Screening for Cervical Precancer 59 5.1 Introduction 59 5.2 Cytologic classifications 59 5.3 Cytologic reporting 60 5.4 Clinical referral 63 5.5 Cytodiagnosis of cervical glandular intraepithelial neoplasia/adenocarcinoma in situ 66 5.6 Cytologic features of adenocarcinoma 68 5.7 Screening for cervical cancer 68 5.8 Improvements to cervical screening 70 5.9 Cytologic interpretation 72 5.10 Role of human papillomavirus testing in the UK NHS Cervical Screening Programme 72 5.11 Primary screening with human papillomavirus testing 73 5.12 Human papillomavirus test as follow-up after treatment of cervical intraepithelial neoplasia 74 5.13 Human papillomavirus testing to triage minor cytologic lesions 74 5.14 Role of type-specific human papillomavirus tests 74 5.15 Further reading 75 6 Diagnosis of Cervical Precancer: Use of colposcopy 76 6.1 Introduction 76 6.2 Which cytologic abnormalities need further investigation? 76 6.3 Colposcopy: the initial clinical examination 76 6.4 The rationale for the use of colposcopy in the diagnosis of cervical precancer 77 6.5 Colposcopic appearance of the abnormal (atypical) cervical epithelium 78 6.6 The classification of colposcopically abnormal (atypical) cervical epithelium 87 6.7 Colposcopic examination of the precancerous/cancerous cervix 88 6.8 Benign condyloma of cervix 104 6.9 Correlation of diagnostic methods in the detection of cervical squamous precancer 111 6.10 Lack of correlation between diagnostic methods 116 6.11 The diagnosis of early invasion 117 6.12 Preclinical invasive carcinoma (colposcopically overt/suspect): colposcopy and pathology 122 6.13 Precancerous glandular lesions of the cervix 125 6.14 Colposcopic diagnosis of early adenocarcinoma of the cervix 128 6.15 Further reading 135 7 Management of Cervical Precancer 136 7.1 Introduction 136 7.2 Rationale behind treatment 136 7.3 Colposcopic and pathologic characteristics of cervical intraepithelial neoplasia lesions: a prerequisite to treatment 136 7.4 Colposcopically directed biopsy 139 7.5 How to manage abnormal cytology? 140 7.6 Which lesions to treat 143 7.7 Prerequisites for treatment 144 7.8 Methods of treatment 145 7.9 Excision techniques for treating cervical intraepithelial neoplasia 153 7.10 Management of extension of the abnormal (atypical) transformation zone 163 7.11 Hysterectomy in the treatment of cervical intraepithelial neoplasia 166 7.12 Immediate complications of cervical intraepithelial neoplasia treatment 166 7.13 Long-term complications of cervical intraepithelial neoplasia treatment 168 7.14 Follow-up after treatment of cervical intraepithelial neoplasia 171 7.15 Treatment of suspected recurrence 174 7.16 Precancer in pregnancy 174 7.17 Precancer in the HIV-positive patient 178 7.18 Management of early invasive squamous carcinoma of the cervix (FIGO stage I) 180 7.19 Further reading 184 8 Vaginal Intraepithelial Neoplasia 185 8.1 Introduction 185 8.2 Natural history of vaginal intraepithelial neoplasia 185 8.3 Etiology 186 8.4 Clinical presentation 186 8.5 Vaginal intraepithelial neoplasia following hysterectomy 189 8.6 Biopsy of the vaginal intraepithelial neoplasia lesion 191 8.7 Pathology of vaginal intraepithelial neoplasia: is it a precancerous lesion? 193 8.8 Vaginal precancer and cancer: part of the lower genital tract neoplastic syndrome 194 8.9 Treatment of vaginal intraepithelial neoplasia 199 8.10 Further reading 204 9 Vulval Intraepithelial Neoplasia 205 9.1 Introduction 205 9.2 Epidemiology and pathogenesis 205 9.3 Natural history of vulval intraepithelial neoplasia: the rationale for treatment? 207 9.4 Pathology 209 9.5 The clinical examination in general 211 9.6 The clinical examination (specific) 215 9.7 Vulval intraepithelial neoplasia affecting the pilosebaceous unit 222 9.8 Superficially invasive carcinoma of the vulva 223 9.9 Lichen sclerosus 228 9.10 Paget’s disease (non-squamous intraepithelial neoplasia) 230 9.11 Vulval lesions masquerading as cancer or precancer 231 9.12 Skin and accessory appendages that are important for the management of vulval intraepithelial neoplasia 237 9.13 Management of vulval intraepithelial neoplasia 239 9.14 Treatment of superficial invasive vulval carcinoma 254 9.15 Further reading 255 10 Perianal and Anal Intraepithelial Neoplasia 256 10.1 Epidemiology 256 10.2 Etiology 256 10.3 Association with other genital intraepithelial neoplastic diseases 257 10.4 Examination 257 10.5 Presentation 258 10.6 Lesions masquerading as intraepithelial neoplasia 260 10.7 Anal canal involvement 261 10.8 Management and treatment 262 10.9 Further reading 267 11 Genital Tract Adenosis 268 11.1 Introduction 268 11.2 Developmental anatomy 268 11.3 Developmental anomalies caused by diethylstilbestrol 269 11.4 Present situation 272 11.5 Further reading 272 12 Infective and Other Conditions Causing Confusion in Diagnosis of Lower Genital Tract Precancer 273 12.1 Introduction 273 12.2 Trichomonas vaginalis 273 12.3 Bacterial vaginosis 273 12.4 Candidiasis 274 12.5 Herpes genitalis infection 275 12.6 Human papillomavirus infection 279 12.7 Cervical deciduosis in pregnancy 280 12.8 Polypoid lesions of the cervix 282 12.9 Further reading 285 Index 287

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Book SynopsisRadiation oncology, also known as radiation therapy or radiotherapeutics, involves the use of many forms of ionising radiation to kill cancer cells. This edition provides an overview of the clinical parameters of radiation therapy, the biological basis and the physical aspects of radiation therapy.Table of ContentsBasic concepts of clinical radiation oncology; radiation biology for radiation oncologists; physical aspects of radiation therapy; cancer of the skin; cancers of the head and neck - thyroid carcinomas; cancers of the breast; cancer of the thorax; GI malignancies; GU malignancies; GYN malignancies; sarcomas; CNS tumors; lymphomas; paediatric tumours; novel radiotherapeutic approaches.

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Book SynopsisCancer Epigenetics: Biomolecular Therapeutics in Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences.Trade Review“In summary, this book provides a useful in-depth review of the molecular mechanisms which underpin epigenetic processes, their clinical linkage to cancer, particularly paediatric indications, and the therapeutic potential of targeting epigenetic mechanisms. It is of value to those working in, or entering, this complex and fast-moving field and will be most accessible to those with a biological background and interest.” (ChemMedChem, 1 July 2013)Table of ContentsContributors. Preface. SECTION I: EPIGENETICS AND CELL CYCLE. 1 Epigenetic Modulation of Cell Cycle: An Overview (Micaela Montanari, Antonio Giordano, Marcella Cintorino, and Marcella Macaluso). SECTION II: EPIGENETICS AND CELL DEVELOPMENT, SENESCENCE AND DIFFERENTIATION. 2 Epigenetics in Skeletal Muscle Development (Cristina Giacinti and Antonio Giordano). 3 Epigenetic Control in Cellular Senescence (Heike Helmbold, Wolfgang Deppert, and Wolfgang Bohn). 4 Epigenetic Modulation in Cell Development and Differentiation (Mario Mancino, Claudia Esposito, Raffaella Pasquale, Immacolata Vocca, and Francesca Pentimalli). SECTION III: EPIGENETICS AND GENE TRANSCRIPTION. 5 Epigenetic Control of Gene Transcription (Christian Bronner, Mayada Achour, Thierry Chataigneau,and Valerie B. Schini-Kerth). 6 Epigenetics, MicroRNAs, and Cancer: An Update (Giuseppe Russo, Andrew Puca, Francesco Masulli, Stefano Rovetta,Letizia Cito, Debora Muresu, Flavio Rizzolio, and Antonio Giordano). SECTION IV: EPIGENETICS AND CANCER. 7 The Role of Epigenetic Modifications in Cancer (Michael J. Powell, Vladimir M. Popov, Xiang Wang, Steven B. McMahon,Alexander Mazo, and Richard G. Pestell). 8 MBD4/MED1 Protein in DNA Repair and Demethylation, Cancer, and Other Diseases (Serena Buontempo, Mara Sannai, and Alfonso Bellacosa). 9 Epigenetics in Pediatric Cancers (Roberta Ciarapica, Lavinia Raimondi, Federica Verginelli, and Rossella Rota). 10 Epigenetic Mechanisms in Cancer Formation and Progression (Elisabetta Fratta, Luca Sigalotti, Alessia Covre, Giulia Parisi, Riccardo Danielli, Hugues Jean Marie Nicolay, Sandra Coral, and Michele Maio). SECTION V: EPIGENETICS AND ANTICANCER DRUG DEVELOPMENT AND THERAPY. 11 Recent Advances in the Field of Stem Cell Research: Toward the Definition of the Epigenetic and Genetic Codes of Pluripotency (Gaetano Romano). 12 Potential of Heat Shock Protein Targeting for Human Therapy (Laszlo Otvos, Jr). 13 Advances in Stem Cell Therapy for Cancer Research (Andrew Puca and Antonio Giordano). 14 Epigenetic Targets and Drug Development (Paraskevi Vogiatzi, Maria Irene Scarano, and Pier Paolo Claudio). Index.

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Book SynopsisSuitable for clinicians working, teaching, and learning in primary care and outpatient settings, this book answers questions such as: Which statin drug is best at preventing coronary outcomes? What is the advantage of adding a thallium scan to a treadmill test? How many mammograms does it take to save one life in a screening program?Table of ContentsConsultants. List of Contributors. Introduction. Alcoholism problems. Anemia. Anticoagulation. Arterial Disease of the Lower Extremities. Asthma & Chronic Obstructive Pulmonary Disease. Atrial Fibrillation. Breast Disease. Cancer Screening. Cerebrovascular Disease. Coronary Artery Disease. Cough, Bronchitis & Pneumonia. Depression, Anxiety, Panic Disorder & Somatization. Dermatologic Disease. Diabetes Mellitus. Dizziness. Domestic Violence. Dyspepsia, Peptic Ulcer Disease, & Gastroesophageal Reflux Disease. Fatigue. Headache. Heart Failure. Hepatitis A, B & C. HIV Disease. Hyperlipidemia. Hypertension. Irritable Bowel Syndrome. Liver & Biliary Disease. Low Back Pain. Menopause & Hormone Replacement. Musculoskeletal Pain. Obesity. Osteoporosis. Palpitations. Renal Insufficiency. Seizure Disorders. Sexually Transmitted Diseases. Smoking Cessation. Thyroid Disease. Tuberculosis & PPD Testing. Upper Respiratory Infection & Allergic Rhinitis. Valvular Heart Disease. Venous Thromboembolism. Glossary. Index

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Book SynopsisAimed specifically at general practitioners, this new addition to the series covers an important area of cardiovascular therapy. It discusses both the mechanisms of antithrombotic therapy and its uses for parents at risk, and will be a highly practical guide in primary care.Table of ContentsContributors. Preface. An overview of antithrombotic therapy (Andrew D. Blann, Martin J. Landray, Gregory Y H. Lip). Bleeding risks of antithrombotic therapy (David A. Fitzmaurice, Andrew B. Blann, Gregory Y. H. Lip). Venous thromboembolism: pathophysiology clinical features, and prevention (Alexander G. G. Turpie, Bernard S. P. Chin, Gregory Y. H. Lip). Venous thromboembolism: treatment strategies (Alexander G. G. Turpie, Bernard S. P. Chin, Gregory Y. H. Lip). Antithrombotic therapy for atrial fibrillation: clinical aspects (Gregory Y. H. Lip, Robert G. Hart, Dwayne S. G. Conway). Antithrombotic therapy for atrial fibrillation: pathophysiology, acute atrial fibrillation, and cardioversion (Gregory Y. H. Lip, Robert G. Hart, Dwayne S. G. Conway). Antithrombotic therapy in peripheral vascular disease (Andrew J. Makin, Stanley H. Silverman, Gregory Y. H. Lip). Antithrombotic therapy for cerebrovascular disorders (Gregory Y. H. Lip. Sridhar Kamath, Robert G. Hart). Valvar heart disease and prosthetic heart valves (Ira Goldsmith, Alexander G. G. Turpie, Gregory Y. H. Lip). Antithrombotic therapy in myocardial infarction and stable angina (Gregory Y. H. Lip, Bernard S. P. Chin, Neeraj Prasad). Antithrombotic therapy in acute coronary syndromes (Robert D. S. Watson, Bernard S. P. Chin, Gregory Y. H. Lip). Antithrombotic strategies in acute coronary syndromes and percutaneous coronary interventions (Derek L. Connolly, Gregory Y.H. Lip, Bernard S. P. Chin). Antithrombotic therapy in chronic heart failure in sinus rhythm (Gregory Y. H. Lip, Bernard S. P. Chin). Antithrombotic therapy in special circumstances. I—pregnancy and cancer (Bernd Jilma, Sridhar Kamath, Gregory Y. H. Lip). Antithrombotic therapy in special circumstances. II—children, thrombophilia, and miscellaneous conditions (Bernd Jilma, Sridhar Kamath, Gregory Y. H. Lip). Anticoagulation in hospitals and general practice (Andrew D. Blann, David A. Fitzmaurice, Gregory Y. H. Lip). Index

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Book SynopsisThe primary focus of this CD-ROM is on taking a history and eliciting and interpreting clinical signs. This has been achieved by use of videos, photographic images, 3D animation and audio. Although it is not a reference textbook, the aetiology of many respiratory diseases are also covered.Table of ContentsExamination. Infections. Neoplastic disease. Asthma. COPD. Interstitial disease. Pulmonary vascular

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Book SynopsisWhen Your Spouse Has a Stroke will relieve your burden and strengthen your partnership.Trade ReviewThis book is unique and clearly needed by many families of stroke survivors. -- Andreas R. Luft CardioPulse This book is a treasure that each caregiving spouse can mine for helpful suggestions and better ways of handling the kinds of issues we all face. -- Sandra M. Fowler PsycCRITIQUESTable of ContentsAcknowledgmentsPrologue: Setting the Stage for Life after StrokeIntroduction: When Stroke Moves In: How Stroke Affects You and Your Marriage1. The Secret Ingredient: Stroke and Social Support2. You Are the One: Balancing the Roles of Caregiver and Marriage Partner3. A Fine Romance: Sex and Intimacy after Stroke4. Give Me a Break: Support for the Caregiving Spouse5. In Sickness and in Health: Rebuilding Your Marriage after Stroke6. 'Til Death Do Us Part: Going the Distance with Your Spouse after StrokeEpilogue: From This Day On: The Future of CaregivingNotesResourcesIndex

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Book SynopsisNothing short of a call to rework the psychiatric profession, Narrative Psychiatry advocates taking the inherently narrative-centered patient-psychiatrist relationship to its logical conclusion: making the story a central aspect of treatment.Trade Review"Lewis has captured and articulated a method of working with patients that is at once intuitive to seasoned practitioners, while also directing them to novel areas of thinking about and working with patients." (John Z. Sadler, M.D., author of Values and Psychiatric Diagnosis)"Table of ContentsPreface1. Listening to Chekhov2. Narrative Medicine3. Narrative Approaches to Psychotherapy4. Narrative Approaches to Psychotherapy5. Mrs. Dutta and the Literary Case6. Mainstream Stories I: Biopsychiatry, Cognitive Behavioral Therapy, and Psychoanalysis7. Mainstream Stories II: Interpersonal Therapy, Family Therapy, and Humanistic Therapy8. Alternative Stories: Spirtual Therapy, Expressive Therapy, and Cultural, Political, and Feminist Therapies9. Doing Narrative Psychiatry10. Critical ReflectionsAppendix: "Mrs. Dutta Writes a Letter," by Chitra DivakaruniNotesReferencesIndex

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Book SynopsisBack by popular demand! The world′s most widely used medical reference is now in its 20th edition. The Merck Manual of Diagnosis and Therapy now in its 20th edition has been thoroughly updated and thoughtfully expanded with a new larger trim size to include 40% new and revised content.Trade Review"The readability and relevance to clinical practice is outstanding"Table of ContentsGuide for Readers Abbreviations Editors and Editorial Board Consultants Contributors 1 Nutritional Disorders 2 Gastrointestinal Disorders 3 Hepatic and Biliary Disorders 4 Musculoskeletal and Connective Tissue Disorders 5 Pulmonary Disorders 6 Critical Care Medicine 7 Cardiovascular Disorders 8 Ear, Nose, and Throat, and Disorders 9 Dental Disorders 10 Eye Disorders 11 Dermatologic Disorders 12 Hematology and Oncology 13 Endocrine and Metabolic Disorders 14 Immunology; Allergic Disorders 15 Infectious Diseases 16 Psychiatric Disorders 17 Neurologic Disorders 18 Genitourinary Disorders 19 Gynecology and Obstetrics 20 Pediatrics 21 Geriatrics 22 Clinical Pharmacology 23 Injuries; Poisoning 24 Special Subjects Appendixes Ready Reference Guides Normal Laboratory Values Trade Names of Some Commonly Used Drugs Index

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Book SynopsisThe only text-atlas of its kind on this vital subject, Ultrasound Guided Clinical Cytopathology of the Head and Neck presents a painstakingly thorough revision and updating of the well-received Clinical Cytopathology of the Head and Neck.Table of ContentsPreface to the first edition, ix Preface to the second edition, x About the companion website, xi 1 Introduction, 1 1.1 Introduction, 1 1.2 Fine needle aspiration cytology of the head and neck, 1 1.3 Ultrasound guided FNAC, 1 1.4 A Combined US/FNAC approach, 2 1.5 Sampling technique, 2 References, 8 2 Salivary gland, 9 2.1 Introduction, 9 2.2 Diagnostic imaging of salivary glands, 13 2.3 Cytology of the salivary gland, 14 2.4 Salivary gland tumours, 29 2.5 Malignant tumours of the salivary gland, 42 2.6 Miscellaneous tumours, 59 2.7 Clinical management of salivary gland lesions, 64 References, 65 3 Thyroid, 71 3.1 Introduction, 71 3.2 Non]neoplastic and inflammatory conditions, 79 3.4 Malignant tumours, 94 References, 106 4 Lymph nodes, 112 4.1 Introduction, 112 4.2 Non]neoplastic lymphoproliferative conditions, 118 4.3 Hodgkin’s lymphoma, 137 4.4 Non]Hodgkin’s lymphoma, 139 4.5 Metastatic carcinoma in lymph nodes, 160 References, 170 5 Miscellaneous lesions of the head and neck, 176 5.1 Introduction, 176 5.2 Benign soft tissue lesions, 176 5.3 Cysts of the head and neck, 181 5.4 Small round cell tumours, 184 5.5 Locally arising miscellaneous tumours, 189 References, 195 Index, 198

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Book SynopsisFocusing primarily on evaluation of agreement with continuous measurements with additional coverage devoted to categorical measurements, Measuring Agreement Methodology and Applications successfully blends the currently available statistical methodologies for agreement evaluation in a unified, coherent, and lucid manner.Table of ContentsPreface xv 1 Introduction 1 1.1 Preview 1 1.2 Notational Conventions 1 1.3 Basic Characteristics of a Measurement Method 2 1.3.1 A Statistical Model for Measurements 3 1.3.2 Quality Characteristics 3 1.4 Method Comparison Studies 5 1.5 Meaning of Agreement 6 1.6 A Measurement Error Model 8 1.6.1 Identifiability Issues 9 1.6.2 ModelBased Moments 10 1.6.3 Conditions for Perfect Agreement 10 1.6.4 Link to Test Theory 11 1.7 Similarity versus Agreement 11 1.7.1 Evaluation of Similarity 11 1.7.2 Evaluation of Agreement 12 1.8 A Toy Example 13 1.9 Controversies and Our View 14 1.10 Concepts Related to Agreement 15 1.11 Role of Confidence Intervals and Hypotheses Testing 16 1.11.1 Formulating the Agreement Hypotheses 16 1.11.2 Testing Hypotheses Using Confidence Bounds 17 1.11.3 Evaluation of Agreement Using Confidence Bounds 17 1.11.4 Evaluation of Similarity Using Confidence Intervals 18 1.12 Common Models for Paired Measurements Data 18 1.12.1 A Measurement Error Model 19 1.12.2 A MixedEffects Model 20 1.12.3 A Bivariate Normal Model 21 1.12.4 Limitations of the Paired Measurements Design 22 1.13 The BlandAltman Plot 23 1.13.1 The Ideal Plot 23 1.13.2 A Linear Trend in the BlandAltman Plot 25 1.13.3 Heteroscedasticity in the BlandAltman Plot 26 1.13.4 Variations of the BlandAltman Plot 27 1.14 Common Regression Approaches 29 1.14.1 Ordinary Linear Regression 29 1.14.2 Deming Regression 31 1.15 Inappropriate Use of Common Tests in Method Comparison Studies 34 1.15.1 Test of Zero Correlation 34 1.15.2 Paired ttest 36 1.15.3 PitmanMorganand BradleyBlackwood Tests 36 1.15.4 Test of Zero Intercept and Unit Slope 38 1.16 Key Steps in the Analysis of Method Comparison Data 39 1.17 Chapter Summary 40 1.18 Bibliographic Note 41 Exercises 47 2 Common Approaches for Measuring Agreement 53 2.1 Preview 53 2.2 Introduction 53 2.3 Mean Squared Deviation 54 2.4 Concordance Correlation Coefficient 54 2.5 A Digression: Tolerance and Prediction intervals 57 2.5.1 Definitions 57 2.5.2 Normally Distributed Data 58 2.6 Lin’s Probability Criterion and BlandAltman Criterion 59 2.7 Limits of Agreement 60 2.7.1 The Approach 60 2.7.2 Why Ignore the Variability? 61 2.7.3 Limits of Agreement versus Prediction and Tolerance Intervals 62 2.8 Total Deviation Index and Coverage Probability 62 2.8.1 The Approaches 62 2.8.2 Normally Distributed Differences 63 2.9 Inference on Agreement Measures 64 2.10 Chapter Summary 64 2.11 Bibliographic Note 65 Exercises 66 3 A General Approach for Modeling and Inference 71 3.1 Preview 71 3.2 MixedEffects Models 71 3.2.1 The Model 72 3.2.2 Prediction 73 3.2.3 Model Fitting 74 3.2.4 Model Diagnostics 75 3.3 A LargeSample Approach to Inference 76 3.3.1 Approximate Distributions 77 3.3.2 Confidence Intervals 78 3.3.3 Parameter Transformation 80 3.3.4 Bootstrap Confidence Intervals 81 3.3.5 Confidence Bands 83 3.3.6 Test of Homogeneity 83 3.3.7 Model Comparison 84 3.4 Modeling and Analysis of Method Comparison Data 85 3.5 Chapter Summary 88 3.6 Bibliographic Note 89 Exercises 89 4 Paired Measurements Data 95 4.1 Preview 95 4.2 Modeling of Data 95 4.2.1 MixedEffects Model 95 4.2.2 Bivariate Normal Model 97 4.3 Evaluation of Similarity and Agreement 98 4.4 Case Studies 99 4.4.1 Oxygen Saturation Data 99 4.4.2 Plasma Volume Data 101 4.4.3 Vitamin D Data 103 4.5 Chapter Summary 106 4.6 Technical Details 106 4.6.1 MixedEffects Model 106 4.6.2 Bivariate Normal Model 107 4.7 Bibliographic Note 108 Exercises 108 5 Repeated Measurements Data 111 5.1 Preview 111 5.2 Introduction 111 5.2.1 Types of Data 112 5.2.2 Individual versus Average Measurement 113 5.2.3 Example Datasets 113 5.3 Displaying Data 114 5.3.1 Basic Plots 114 5.3.2 Interaction Plots 116 5.4 Modeling of Data 117 5.4.1 Unlinked Data 118 5.4.2 Linked Data 121 5.4.3 Model Fitting and Evaluation 123 5.5 Evaluation of Similarity and Agreement 123 5.6 Evaluation of Repeatability 124 5.6.1 Unlinked Data 125 5.6.2 Linked Data 125 5.7 Case Studies 126 5.7.1 Kiwi Data 126 5.7.2 Oximetry Data 129 5.8 Chapter Summary 133 5.9 Technical Details 134 5.9.1 Unlinked Data 134 5.9.2 Linked Data 134 5.10 Bibliographic Note 135 Exercises 137 6 Heteroscedastic Data 141 6.1 Preview 141 6.2 Introduction 141 6.2.1 Diagnosing Heteroscedasticity 142 6.2.2 Example Datasets 143 6.3 Variance Function Models 144 6.4 Repeated Measurements Data 146 6.4.1 A Heteroscedastic MixedEffects Model 147 6.4.2 Specifying the Variance Function 149 6.4.3 Model Fitting and Evaluation 150 6.4.4 Testing for Homoscedasticity 151 6.4.5 Evaluation of Similarity, Agreement, and Repeatability 151 6.4.6 Case Study: Cholesterol Data 152 6.5 Paired Measurements Data 162 6.5.1 A Heteroscedastic Bivariate Normal Model 162 6.5.2 Specifying the Variance Function 163 6.5.3 Model Fitting and Evaluation 164 6.5.4 Testing for Homoscedasticity 164 6.5.5 Evaluation of Similarity and Agreement 164 6.5.6 Case Study: Cyclosporin Data 165 6.6 Chapter Summary 171 6.7 Technical Details 171 6.7.1 Repeated Measurements Data 171 6.7.2 Paired Measurements Data 173 6.8 Bibliographic Note 174 Exercises 174 7 Data from Multiple Methods 177 7.1 Preview 177 7.2 Introduction 177 7.3 Displaying Data 179 7.4 Example Datasets 179 7.4.1 Systolic Blood Pressure Data 180 7.4.2 Tumor Size Data 180 7.5 Modeling Unreplicated Data 184 7.6 Modeling Repeated Measurements Data 186 7.6.1 Unlinked Data 186 7.6.2 Linked Data 187 7.7 Model Fitting and Evaluation 189 7.8 Evaluation of Similarity and Agreement 190 7.9 Evaluation of Repeatability 191 7.10 Case Studies 192 7.10.1 Systolic Blood Pressure Data 192 7.10.2 Tumor Size Data 195 7.11 Chapter Summary 198 7.12 Technical Details 198 7.13 Bibliographic Note 200 Exercises 200 8 Data with Covariates 205 8.1 Preview 205 8.2 Introduction 205 8.3 Modeling of Data 206 8.3.1 Modeling Means of Methods 206 8.3.2 Modeling Variances of Methods 207 8.3.3 Data Models 208 8.3.4 Model Fitting and Evaluation 211 8.4 Evaluation of Similarity, Agreement, and Repeatability 211 8.4.1 Measures of Agreement for Two methods 212 8.4.2 Measures of Agreement for More Than Two Methods 213 8.4.3 Measures of Repeatability 213 8.4.4 Inference on Measures 214 8.5 Case Study 214 8.6 Chapter Summary 224 8.7 Technical Details 225 8.8 Bibliographic Note 226 Exercises 226 9 Longitudinal Data 229 9.1 Preview 229 9.2 Introduction 229 9.2.1 Displaying Data 231 9.2.2 Percentage Body Fat Data 231 9.3 Modeling of Data 234 9.3.1 The Longitudinal Data Model 236 9.3.2 Specifying the Mean Functions 237 9.3.3 Specifying the Correlation Function 237 9.3.4 Model Fitting and Evaluation 240 9.4 Evaluation of Similarity and Agreement 241 9.5 Case Study 242 9.6 Chapter Summary 247 9.7 Technical Details 247 9.8 Bibliographic Note 249 Exercises 250 10 A Nonparametric Approach 253 10.1 Preview 253 10.2 Introduction 253 10.3 The Statistical Functional Approach 255 10.3.1 A Weighted Empirical CDF 256 10.3.2 Distributions Induced by Empirical CDF 256 10.4 Evaluation of Similarity and Agreement 258 10.5 Case Studies 259 10.5.1 Unreplicated Blood Pressure Data 259 10.5.2 Replicated Blood Pressure Data 263 10.6 Chapter Summary 267 10.7 Technical Details 267 10.7.1 The Matrix 268 10.7.2 Estimation of 269 10.7.3 Influence Functions for the Measures 270 10.7.4 TDI Confidence Bounds 270 10.7.5 Summary of Steps 271 10.8 Bibliographic Note 271 Exercises 272 11 Sample Size Determination 279 11.1 Preview 279 11.2 Introduction 279 11.3 The Sample Size Methodology 281 11.3.1 Paired Measurements Design 281 11.3.2 Repeated Measurements Design 281 11.4 Case Study 282 11.5 Chapter Summary 286 11.6 Bibliographic Note 286 Exercises 287 12 Categorical Data 289 12.1 Preview 289 12.2 Introduction 289 12.3 Experimental Setups and Examples 290 12.3.1 Types of Data 290 12.3.2 Illustrative Examples 290 12.3.3 A Graphical Approach 292 12.4 Cohen’s Kappa Coefficient for Dichotomous Data 293 12.4.1 Definition and Basic Properties: Two Raters 293 12.4.2 Sample Kappa Coefficient 297 12.4.3 Agreement with a Gold Standard 298 12.4.4 Unbiased Raters: Intraclass Kappa 299 12.4.5 Multiple Raters 300 12.4.6 Combining and Comparing Kappa Coefficients 301 12.4.7 Sample Size Calculations 302 12.5 Kappa Type Measures for More Than Two Categories 303 12.5.1 Two Fixed Raters with Nominal Categories 303 12.5.2 Two Raters with Ordinal Categories: Weighted Kappa 303 12.5.3 Multiple Raters 304 12.6 Case Studies 305 12.6.1 Two Raters with Two Categories 305 12.6.2 Weighted Kappa: Multiple Categories 306 12.7 Models for Exploring Agreement 306 12.7.1 Conditional Logistic Regression Models 306 12.7.2 LogLinear Models 307 12.7.3 A Generalized Linear MixedEffects Model 308 12.8 Discussion 309 12.9 Chapter Summary 310 12.10 Bibliographic Note 311 Exercises 312 References 319 Dataset List 331 Index 333

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Book SynopsisThe process of labor and delivery has been one of the most perilous activities in human life. The awkward evolutionary compromises giving rise to humans makes birthing potentially life threatening for both mother and child. Despite the development of modern care, labor and delivery continues to be a dangerous process even though the levels of fatality have decreased over the past several decades. This clinically focused guide to modern labor and delivery care covers low and high-risk situations, the approach of the team in achieving a successful outcome and what to consider when quick decisions have to be made. Aimed at both trainee and practicing obstetrician-gynecologists, this new edition includes practical guidance such as algorithms, protocols, and quick-reference summaries. It is squarely focused on the process of birth and concentrates on modern clinical concerns, blending science with clinical applications.Table of ContentsContributor List vii 1 Antenatal Preparation for Labor 1Molly Stout, Jessica C. Garrett, and David M. Stamilio 2 Normal Labor and Delivery 23Shu Qin Wei, Jun Zhang, Romy, Leigh McMaster, and William D. Fraser 3 Management of Labor and Delivery in Low-Risk Subjects 49Anthony Shanks and Alison Cahill 4 Induction and Augmentation of Labor 62Karin A. Fox, Mildred M. Ramirez, and Susan M. Ramin 5 Fetal Monitoring and Assessment 86Alison Cahill 6 Operative Vaginal Delivery 108Katherine R. Goetzinger and George A. Macones 7 Cesarean Delivery 130Methodius G. Tuuli and Molly J. Stout 8 Trial of Labor after Cesarean 147William Grobman and Emily Miller 9 Malpresentation and Malposition 172Yvonne W. Cheng and Aaron B. Caughey 10 Multiple Gestations 193Laura Houston and Roger Newman 11 Obstetrical Emergencies 225Christina S. Han and Christian M. Pettker 12 Surgical Management of Obstetrical Emergencies 258Laurie S. Swaim and Gary A. Dildy, III 13 Maternal Disorders Affecting Labor and Delivery 283Audrey Merriam and Anthony Sciscione 14 Fetal Disorders Affecting Labor and Delivery 348Audrey Merriam and Anthony Sciscione 15 Labor and Delivery Management of the Obese Gravida 362Jordan H. Perlow, Megan Jones, and John Ozimek 16 Intrapartum and Postpartum Infections 376Scott A. Sullivan and Christopher Goodier 17 Obstetric Anesthesia 416Emily J. Baird, Richard C. Month, and Valerie A. Arkoosh 18 Postpartum Care 469Audrey Lyndon, Kirsten Wisner, and Kristina J. Hung 19 Development of an Obstetrical Patient Safety Program 510Christian M. Pettker and Edmund F. Funai Index

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Book SynopsisGuides readers on the proper use of in vitro drug release methodologies in order to evaluate the performance of special dosage forms In the last decade, the application of drug release testing has widened to a variety of novel/special dosage forms. In order to predict the in vivo behavior of such dosage forms, the design and development of the in vitro test methods need to take into account various aspects, including the dosage form design and the conditions at the site of application and the site of drug release. This unique book is the first to cover the field of in vitro release testing of special dosage forms in one volume. Featuring contributions from an international team of experts, it presents the state of the art of the use of in vitro drug release methodologies for assessing special dosage forms' performances and describes the different techniques required for each one. In Vitro Drug Release Testing of Special Dosage Forms covers the in vitro release testing of: lipid baseTable of ContentsList of Contributors xvii Series Preface xix Preface xxi Part I Oral Dosage Forms 1 1 Lipid‐Based Oral Formulations 3Murat Kilic, Aikaterini Avzoti, Jennifer Dressman, and Christos Reppas 1.1 Introduction 3 1.2 Levels of Release Testing for Lipid‐Based Dosage Forms 7 1.2.1 Dilution 7 1.2.2 Dispersion and Drug Release 9 1.2.3 Digestion 13 1.2.4 Assessing Direct Uptake from the Vehicle 16 1.3 Case Examples 16 1.3.1 Compendial or Fed State Biorelevant Media to Evaluate Fenofibrate Lipid‐based Formulations? 17 1.3.2 Paddle or Biodis Method for Testing a Lipid‐based Formulation? 17 1.3.3 Does Nifedipine Precipitate after Administration as a Soft Gelatin Capsule? 19 1.3.4 Screening of Indomethacin Lipid‐Based Formulations 19 1.3.5 Effect of Supersaturation on In Vivo Performance 22 1.4 Conclusions and Future Directions 22 References 23 2 Chewable Oral Drug Products 27Johannes Kramer, Jayachandar Gajendran, Alexis Guillot, and Abdulwahab Barakat 2.1 Introduction 27 2.1.1 Dosage Forms for Which Drug Release Occurs in the Oral Cavity 27 2.1.2 Chewable Dosage Forms Classification 28 2.2 The Oral Cavity 30 2.2.1 Anatomy of the Oral Cavity 30 2.2.2 Physiological Conditions from the Perspective of In Vivo Performance 30 2.2.3 Mechanical Forces 31 2.2.4 Need for Masticatory Action 31 2.2.5 Saliva Composition 32 2.2.6 Oral Absorption vs. Subsequent Absorption in the GI Tract 32 2.3 Drug Substances Used in Chewable Dosage Forms 33 2.4 Technology 33 2.4.1 Chewable Tablets 34 2.4.2 Medicated Gums 34 2.4.2.1 Conventional Method (Extrusion) 34 2.4.2.2 Direct Compression Method 34 2.4.3 Soft Gel Capsules as Chewable Dosage Forms 35 2.5 Pharmacopoeial Requirements 35 2.5.1 Chewable Tablets and Capsules 35 2.5.1.1 US FDA and USP Requirements for In Vitro Performance Testing of Chewable Tablets 35 2.5.1.2 Rationale for Use of the Reciprocating Cylinder Apparatus (USP Apparatus 3) 36 2.5.1.3 Current Status of Drug Release/Dissolution Testing Apparatus for Chewable Drug Products 36 2.5.2 Medicated Gums 36 2.5.2.1 Rationale for In Vitro Performance Testing of Medicated Gums 41 2.5.3 Apparatus for In Vitro Drug Release Testing of Medicated Gums 41 2.5.3.1 Non‐Compendial Setup: A USP Apparatus 2‐based Method with Modified Gums 41 2.5.4 Compendial Apparatus 44 2.5.4.1 Ph.Eur. Chewing Apparatus A (Chapter 2.9.25) 44 2.5.4.2 Ph.Eur. Chewing Apparatus B (Chapter 2.9.25) 44 2.5.5 In Vitro–In Vivo Correlation (IVIVC) 45 2.6 Summary and Conclusion 49 References 50 Part II Non-oral Dosage Forms 55 3 Injectables 57Susan D’Souza 3.1 Introduction 57 3.2 Significance of In Vitro Release Testing 60 3.3 Considerations in Method Development 61 3.3.1 Sink Conditions 63 3.3.2 Burst Release 63 3.3.3 Stability of Drug 64 3.3.4 Completeness of In Vitro Release 64 3.3.5 Robustness of Technique 65 3.3.6 Accelerated Release 65 3.3.7 In Vitro – In Vivo Correlations (IVIVCs) 66 3.4 In Vitro Release Methods 66 3.4.1 Sample and Separate 67 3.4.1.1 Volume of Release Media 67 3.4.1.2 Agitation Conditions 67 3.4.1.3 Sampling Techniques 67 3.4.1.4 Sampling Volume 68 3.4.2 Continuous Flow 68 3.4.2.1 CF Setups 69 3.4.2.2 Pumps and Flow Rates 70 3.4.2.3 Sampling Techniques 70 3.5 Dialysis Method 71 3.5.1 Dialysis Setup 72 3.5.2 Volume of Release Media 73 3.5.3 Sampling Technique and Volume 73 3.6 Accelerated In Vitro Release 74 3.7 In Vitro – In Vivo Correlations (IVIVCs) 76 References 78 4 Drug‐Eluting Stents 87Anne Seidlitz 4.1 Drug‐Eluting Stents: Combination Products at the Interface of Medical Devices and Medicinal Products 87 4.2 DES Characteristics 88 4.3 In Vivo Stent Position and the Resulting Challenges for In Vitro Release Testing of Coronary Stents 90 4.4 Guidelines, Prerequisites, and General Recommendations on DES Testing 92 4.5 Currently Used Test Methods 93 4.5.1 Media 93 4.5.2 Apparatus 96 4.6 Toward More Biorelevant Testing Conditions and New Challenges for DES Testing 101 4.7 Non‐Vascular Stents 107 4.8 Drug‐Coated Balloons: An Alternative to DESs for a Wide Range of Indications? 108 4.9 Concluding Remarks 109 References 110 5 In Vitro Dissolution for Inhalation Products 119Annalisa Mercuri and Nikoletta Fotaki 5.1 Introduction 119 5.2 The Environment of the Human Lungs 120 5.2.1 The Anatomy of Bronchi and Alveoli 121 5.2.2 Airway Surface Liquid (ASL) 121 5.2.2.1 The Composition of Humans Lung Fluids in the Disease State 123 5.2.2.2 Surface Tension 125 5.2.2.3 Mucus Production and Mucociliary Clearance 125 5.3 Regulatory Perspectives and Current Practices for Testing Inhaled Products 125 5.3.1 Compendial Methods for Testing Inhaled Products 126 5.3.1.1 Andersen Cascade Impactor (ACI) 127 5.3.1.2 Glass Twin Impinger 127 5.3.1.3 Marple‐Miller Impactor (MMI) 129 5.3.1.4 Multi‐Stage Liquid Impinger (MSLI) 129 5.3.1.5 Next Generation Impactor (NGI) 130 5.3.1.6 Analysis of the In Vitro Deposition Data of Inhaled Particles 130 5.3.1.7 In Vitro–In Vivo Deposition Correlations 131 5.3.2 Dissolution Methods for Inhaled Products 132 5.3.2.1 Two‐Stage Impinger 133 5.3.2.2 Horizontal Diffusion Cell 133 5.3.2.3 Static Dissolution Cell 133 5.3.2.4 Shaking Incubator 133 5.3.2.5 Paddle Dissolution Apparatus (USP II Apparatus) 135 5.3.2.6 Dialysis Membranes 136 5.3.2.7 Flow‐through Cell (USP IV Apparatus) 137 5.3.2.8 Transwell™ Method 137 5.3.2.9 Franz Cell Method 137 5.3.3 Dissolution Methods with Integrated Deposition and Cell Permeation Models 138 5.4 Simulated Lung Fluids 139 5.5 Pulmonary Biopharmaceutical Classification System 143 5.6 Conclusions 143 References 144 6 Topicals and Transdermals 155Kailas Thakker 6.1 Introduction 155 6.2 In Vitro Release Studies for Topical Dosage Forms 156 6.2.1 Drug Release from Semisolid Dosage Forms – Theory and Calculations 157 6.2.2 Compendial Apparatus 158 6.2.2.1 Vertical Diffusion Cell 158 6.2.2.2 Immersion Cell 160 6.2.2.3 USP Apparatus 4 163 6.2.3 Method Development: Points to Consider 163 6.2.3.1 Selection of the Receiving Medium 165 6.2.3.2 Selection of the Membrane 166 6.2.3.3 Apparatus Qualification 166 6.2.3.4 Test Procedure 166 6.2.4 Custom‐Designed Cells 167 6.3 In Vitro Release Studies for Transdermal Systems 167 6.3.1 Compendial Apparatus 168 6.3.1.1 The Paddle over Disc Apparatus 168 6.3.1.2 The Reciprocating Holder Apparatus 168 6.4 Conclusions 171 References 171 7 Vaginal and Intrauterine Delivery Systems 177Sandra Klein and Katharina Tietz 7.1 Vaginal and Uterine Anatomy and Physiology Relevant to Drug Delivery 177 7.1.1 Vaginal Anatomy 177 7.1.2 Vaginal Secretions/Vaginal Fluid 179 7.1.3 Vaginal Microflora and pH 179 7.1.4 Uterine Anatomy 179 7.1.5 Cervix Anatomy 180 7.1.6 Uterine and Cervical Secretions/Cervical and Uterine Fluid 180 7.2 Vaginal and Intrauterine Drug Delivery 182 7.3 Standard Dissolution Test Methods for Vaginal and Intrauterine Delivery Systems 183 7.3.1 Official Dissolution Methods 183 7.4 Predictive Dissolution Test Methods for Vaginal and Intrauterine Delivery Systems 186 7.4.1 Test Equipment 187 7.4.2 Test Media 188 7.4.2.1 Simulated Vaginal Fluids 188 7.4.2.2 Simulated Intrauterine Fluids 192 7.4.2.3 Other Genital Fluids 193 7.4.2.4 Summary 194 7.4.3 Case Studies 194 7.4.3.1 Dissolution Test Methods for Vaginal Tablets 195 7.4.3.2 Dissolution Test Methods for Vaginal Suppositories 198 7.4.3.3 Dissolution Test Methods for Vaginal Gels 199 7.4.3.4 Dissolution Test Methods for Vaginal Films 201 7.4.3.5 Dissolution Test Methods for Vaginal Rings 202 7.4.3.6 Dissolution Test Methods for Intrauterine Delivery Systems 205 7.4.4 Conclusion and Future Directions 205 References 206 8 Rectal Dosage Forms 211Sandra Klein 8.1 Rectal Anatomy and Physiology Relevant to Drug Delivery 211 8.1.1 Rectal Anatomy and Physiology 211 8.1.2 Rectal Secretions and Rectal Fluid Properties 213 8.2 Rectal Drug Delivery 213 8.3 Standard Dissolution Test Methods for Rectal Dosage Forms 215 8.3.1 Official Dissolution Methods 215 8.4 Predictive Dissolution Test Methods for Rectal Dosage Forms 218 8.4.1 Test Equipment 218 8.4.2 Test Media 219 8.4.3 Case Studies 219 8.4.3.1 Dissolution Test Methods for Suppositories 220 8.4.3.2 Dissolution Test Methods for Rectal Capsules 229 8.4.3.3 Dissolution Test Methods for Rectal Gels 229 8.4.4 Conclusion and Future Directions 230 References 231 9 Ophthalmic Dosage Forms 235Christian Simroth‐Loch, Werner Weitschies, and Clive G. Wilson 9.1 Introduction 235 9.2 The Tear Film 236 9.2.1 Tear Characteristics 236 9.2.2 Tear Secretion: Enzymes and Proteins 237 9.2.3 Tear Secretion: Lipids 237 9.2.4 Osmolality 237 9.2.5 Tear Secretion: pH 237 9.2.6 Tear Secretion: Surface Tension 237 9.2.7 Tear Viscosity 238 9.3 Delivery Volume 238 9.4 Ophthalmic Formulations 239 9.4.1 Drug Salts 239 9.4.2 Tonicity Adjusters 240 9.4.3 Buffers 240 9.4.4 Preservatives 240 9.4.5 Polymers 240 9.4.6 Ethylenediaminepentaacetic acid (EDTA) 241 9.5 In Vitro Testing for Ophthalmic Formulations 241 9.5.1 Media to Simulate Ocular Fluids 241 9.5.2 Topical Ocular Delivery Systems and In Vitro Testing 242 9.5.3 Intraocular Delivery Systems and In Vitro Testing 243 9.5.3.1 Periocular Injections and Implants 243 9.5.3.2 Intravitreal Injections and Implants 245 9.6 Concluding Remarks 246 References 247 10 Regulatory Considerations 253Vivian A. Gray 10.1 Introduction 253 Part One: Review of Documents Related to In Vitro Release Testing 253 10.2 Compendial Chapters with Legal Implications 253 10.2.1 USP General Chapter <711> Dissolution 254 10.2.2 Ph.Eur. Chapters on Dissolution 254 10.2.2.1 Ph.Eur. 2.9.3 Dissolution Test for Solid Dosage Forms 254 10.2.2.2 Ph.Eur. 2.9.42 Dissolution Test for Lipophilic Solid Dosage Forms 255 10.2.3 JP 6.10 Dissolution Test 255 10.2.4 Harmonization of Dissolution Chapters 256 10.2.5 The International Pharmacopoeia 256 10.2.6 Testing of Transdermal Dosage Forms 257 10.2.6.1 USP General Chapter Drug Release <724> 257 10.2.6.2 Dissolution Testing for Transdermal Patches EP 2.9.4 257 10.2.7 Dissolution Test for Medicated Chewing Gums, EP 2.9.25 258 10.2.8 Disintegration Testing 258 10.2.8.1 USP General Chapter Disintegration <701> 258 10.2.8.2 Ph.Eur. Disintegration Testing 259 10.2.8.3 JP Disintegration Test 6.09 260 10.3 Compendial Chapters, Non‐binding 261 10.3.1 The Dissolution Procedure: Development and Validation USP General Chapter <1092> 261 10.3.2 Ph.Eur. Recommendations on Dissolution Testing 5.17.1 261 10.3.3 USP General Chapter In Vitro and In Vivo Evaluation of Dosage Forms <1088> 262 10.3.4 USP General Chapter Semisolid Drug Products‐Performance Tests <1724> 262 10.3.5 Capsules‐Dissolution Testing and Related Quality Attributes USP General Chapter <1094> 262 10.3.6 Assessment of Drug Performance‐Bioavailability, Bioequivalence, and Dissolution USP General Chapter <1090> 263 10.4 Guidances Related to In Vitro Release Testing 263 10.4.1 FDA Guidances 264 10.4.1.1 Dissolution Testing of Immediate‐Release Solid Oral Dosage Forms 264 10.4.1.2 Extended‐Release Oral Dosage Forms: Development, Evaluation, and Application of In Vitro–In Vivo Correlations 265 10.4.1.3 Waiver of In Vivo Bioavailability and Bioequivalence Studies for Immediate‐Release Solid Oral Dosage Forms Based on a BCS 265 10.4.1.4 Bioavailability and Bioequivalence Studies for Orally Administered Drug Products – General Considerations 266 10.4.1.5 SUPAC Guidances for Immediate‐Release [36], Extended‐Release [37], and Non‐Sterile Semisolids [19] 266 10.4.1.6 Orally Disintegrating Tablets 268 10.4.1.7 The Use of MC of Dissolution Apparatus 1 and 2 – Current Good Manufacturing Practice (CGMP) 268 10.4.1.8 Dissolution Testing and Specification Criteria for Immediate‐Release Solid Oral Dosage Forms Containing BCS Class 1 and 3 Drugs 268 10.4.1.9 Quality Attribute Considerations for Chewable Tablets 269 10.4.2 EMA Guidances 269 10.4.2.1 Guideline on Quality of Oral Modified‐Release Products 269 10.4.2.2 Guideline on Quality of Transdermal Patches 270 10.4.2.3 Guideline on the Investigation of Bioequivalence 270 10.4.3 Japanese Guidelines 271 10.4.3.1 Guideline for the Design and Evaluation of Oral Prolonged‐Release Dosage Forms 271 10.4.3.2 Guideline for Bioequivalence Studies of Generic Products 271 10.4.3.3 Guideline for Bioequivalence Studies for Different Strengths of Oral Solid Dosage Forms 272 10.4.3.4 Guideline for Bioequivalence Studies for Formulation Changes of Oral Solid Dosage Forms 272 10.4.3.5 Guideline for Bioequivalence Studies for Different Oral Solid Dosage Forms 272 10.4.4 ICH Guidelines 272 10.4.4.1 Q6A Specifications: Test Procedures and Acceptance Criteria for New Drug Substances and New Drug Products: Chemical Substances 273 10.4.4.2 Evaluation and Recommendation of Pharmacopeial Texts for Use in the ICH Regions on Dissolution Test General Chapter Q4B Annex 7(R2) 273 10.4.4.3 Evaluation and Recommendation of Pharmacopeial Texts for Use in the ICH Regions on Disintegration Test General Chapter Q4B Annex 5(R1) 273 10.4.5 Other Guidelines 273 10.4.5.1 FIP Guidelines for Dissolution Testing of Solid Oral Products 273 10.4.5.2 FIP/AAPS Guidelines for Dissolution/In Vitro Release Testing of Novel/Special Dosage Forms 274 10.4.5.3 Specifications for Pharmaceutical Preparations (Forty‐Sixth Report), WHO Technical Report Series 970 274 Part Two: Role of Method Development in Setting Clinically Relevant Specifications 275 10.5 Considerations in Early Method Development 275 10.6 Choice of Media 276 10.7 Discriminatory Power of the Method 277 10.8 In Vitro Release Testing for Special Dosage Forms 278 10.9 Resources 278 Useful Web Sites 278 Bibliography 279 Acknowledgments 279 References 279 Index 285

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Book SynopsisTargeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy. Introduces cutting-edge bench to bedside and back' breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancerCovers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicineSummarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalitiesTable of ContentsList of Contributors, vii Series Foreword, xiii Foreword, xv Preface, xvii Part I Principles of Targeted Therapies 1 Toward Personalized Therapy for Cancer, 3Ashley M. Holder and FundaMeric-Bernstam 2 Combining Targeted Therapies, 14Jordi Rodon, Analia Azaro, Davis Torrejon, and Razelle Kurzrock 3 Principles of Targeted Immunotherapy, 27Susanne H. C. Baumeister and Glenn Dranoff 4 Cancer Stem Cell Principles, 39Allison C. Sharrow, Gabriel Ghiaur, and Richard J. Jones 5 The Tumor Microenvironment as a Target for Therapeutic Intervention, 47Hua Fang and Yves A. DeClerck 6 The Role of Angiogenesis in Cancer, 64Morgan Taylor, Robert L. Coleman, and Anil K. Sood 7 Epigenetics and Epigenetic Therapy of Cancer, 72Omotayo Fasan, Patrick Boland, PatriciaKropf, and Jean-Pierre J. Issa 8 The Role of microRNAs in Cancer, 80Gianpiero Di Leva and Carlo M. Croce 9 AcuteMyeloidLeukemia, 89Ofir Wolach and Richard M. Stone 10 Targeted and Functional Imaging, 101Jian Q. (Michael) Yu, Drew A. Torigian, and Abass Alavi Part II Targeted Therapy in Hematological Malignancies 11 Targeted Therapies in Chronic Myeloid Leukemia, 113Elias Jabbour and Jorge Cortes 12 Targeted Therapy for Acute Lymphoblastic Leukemia, 121Nitin Jain, Susan O’Brien, and Farhad Ravandi-Kashani 13 Chronic Lymphocytic Leukemia, 130Preetesh Jain and Susan O’Brien 14 Multiple Myeloma, 145Giada Bianchi and Kenneth C. Anderson 15 The Impact of Genomics on Targeted Therapy in Multiple Myeloma and Lymphomas, 157Jens G. Lohr and Birgit Knoechel 16 Targeted Therapy in Myelodysplastic Syndromes, 162Guillermo Montalb´an-Bravo and Guillermo Garc´ýa-Manero 17 Lymphoma and Targeted Therapies, 169Sonali M. Smith and Julie M. Vose Part III Targeted Therapy in Solid Tumors 18 Targeted Therapy in Solid Tumors: Brain, 179Shiao-PeiWeathers, Barbara J. O’Brien, John F. de Groot, andW. K. Alfred Yung 19 Targeted Therapy for Breast Cancer, 190Harold J. Burstein 20 Targeted Therapy in Solid Tumors: Colorectal Cancer, 193Maen Abdelrahim, Scott Kopetz, and David Menter 21 Endometrial Cancer, 205Jessica L. Bowser, Russell R. Broaddus, Robert L. Coleman, and Shannon N. Westin 22 Targeted Therapy in Solid Tumors: Head and Neck, 216Marcus M. Monroe and Jeffrey N. Myers 23 Targeted Therapy in Solid Tumors: Lung Cancer, 224Saiama N.Waqar, Daniel Morgensztern, and Roy S. Herbst 24 Targeted Therapy in Melanoma, 231Keith T. Flaherty 25 Ovarian Cancer, 240Shannon N.Westin, Larissa A. Meyer, and Robert L. Coleman 26 Molecular Therapeutics: Pancreatic Cancer, 255David Fogelman, Milind Javle, and James Abbruzzese 27 Targeted Therapies for Pediatric Solid Tumors, 263Jasmine Quynh Dao and Patrick A. Zweidler-McKay 28 Prostate Cancer, 273William G. Nelson, Michael C. Haffner, and Srinivasan Yegnasubramanian 29 Renal Cell Carcinoma and Targeted Therapy, 287Benjamin A. Gartrell, Alexander C. Small, William K. Oh, and Matthew D. Galsky 30 Targeted Therapy in Solid Tumors: Sarcomas, 296Anthony P. Conley, Vinod Ravi, and Shreyaskumar Patel Part IV Targeted Therapy for Specific Molecular Aberrations31 RAS-RAF-MEK Pathway: Aberrations and Therapeutic Possibilities, 305Javier Munoz and Filip Janku 32 The Phosphatidylinositol 3-Kinase Pathway in Human Malignancies, 315Samuel J. Klempner,Thanh-Trang Vo, Andrea P. Myers, and Lewis C. Cantley 33 Current Status and Future Direction of PARP Inhibition in Cancer Therapy, 325Saeed Rafii, Stan Kaye and Susana Banerjee 34 Targeting the c-Met Kinase, 341Chad Tang, M. Angelica Cortez, David Hong, and James W. Welsh 35 KIT Kinase, 347Scott E. Woodman 36 TP53, 353Kensuke Kojima and Michael Andreeff Part V Future Perspectives 37 Future Perspectives, 363Rabih Said and Apostolia-Maria Tsimberidou Index, 371

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