Cellular physiology Books
HarperCollins Publishers The Cancer Code A Revolutionary New Understanding
Book SynopsisOur understanding of cancer is slowly undergoing a revolution, allowing for the development of more effective treatments. For the first time ever, the death rate from cancer is showing a steady decline but the War on Cancer' has hardly been won.InThe Cancer Code,Dr Jason Fung offers a revolutionary new understanding of this invasive, often fatal disease whatit is,howit manifests andwhyit is so challenging to treat. In this rousing narrative, Dr Fung identifies the medical community's many missteps in cancer research in particular, its focus on genetics, or what he terms the seed' of cancer, at the expense of examining the soil,' or the conditions under which cancer flourishes. Dr Fung whose ground-breaking work in the treatment of obesity and diabetes has won him international acclaim suggests that the primary disease pathway of cancer is caused by the dysregulation of insulin. In fact, obesity and type 2 diabetes significantly increase an individual's risk of cancer.In this acces
£13.49
Oxford University Press Histopathology Fundamentals of Biomedical Science
Book SynopsisHistopathology describes the processes and practices that are central to the role of the histopathologist within a functioning diagnostic laboratory, from pre-sampling to diagnosis to laboratory management.Trade ReviewIt is very simply and clearly written in language that is easy to understand for the non-specialist. It describes day-to-day histopathology lab practice with clarity and the case studies are very helpful to illustrate the applications of the techniques. * Susan Brooks, Oxford Brookes University *The strength of the book is its detail. The book contains information that is completely lacking from other histopathology books. Overall I think that it is a great textbook for biomedical students and academics. * Akis Karakesisoglou, Durham University *Any potential biomedical scientist with an interest in histopathology, and sound knowledge of the contents of this well- written and nicely-illustrated text together with appropriate practical experience would be well on their way to becoming a valuable member of the team that comprises the core of todays histopathology laboratory. The text will make a valuable addition to any library associated with laboratories performing histopathological techniques. * Judy Brincat, Histology Group of Victoria *Table of Contents1: Dr Guy Orchard, Mr David Muskett, Dr Anne Warren: What is histopathology? 2: Mr David Muskett: Fixation and specimen handling 3: Ms Vanda McTaggart, Dr Sue Pritchard, Dr Anne Warren: Data recording and histopathology dissection 4: Mr David Muskett: Routine staining, processing and embedding 5: Mr David Muskett and Dr Guy Orchard: Special stains 6: Dr Guy Orchard , Mrs Chantell Hodgson, Mr Brian Nation: Artefacts 7: Dr Guy Orchard and Mr Mohammad Shams: Mohs procedures 8: Dr Merdol Ibrahim and Dr Guy Orchard: Immunocytochemical techniques 9: Mr David Muskett, Dr Guy Orchard, Dr Anne Warren: Analytical immunocytochemistry 10: Dr Tony Warford and Dr Emanuela Volpi: In situ hybridization: concepts and applications 11: Mr Brendan O'Sullivan and Dr Phillipe Taniere: Molecular diagnostics: techniques and applications 12: Dr Phillipe Taniere: Molecular diagnostics in action 13: Dr Guy Orchard and Dr Sue Pritchard: Histopathology reporting 14: Dr Guy Orchard: Microscopy and digital pathology 15: Prof David Furness: Electron microscopy in diagnosis 16: Ms Ishbel Gall and Dr Mike Osborne: Mortuary practice 17: Ms Sue Alexandra and Ms Patricia Fernando: Essentials of laboratory management
£44.99
Oxford University Press Molecular Diagnostics
Book SynopsisOne of the most notable trends in biomedical science in recent years has been the increasing use of molecular techniques as part of the diagnosis of disease. As such, there is a growing need for students to understand the technological basis of molecular analysis and to have a comprehensive appreciation of their use in diagnosis. Combining coverage of molecular techniques with their application to diagnostic pathology, this book provides students with a thorough and up to date appreciation of the scope of molecular analysis, the principles of the technology used, and thematic diagnostic application. As part of the Fundamentals of Biomedical Science series, the book provides a unique blend of theory and practice, featuring a range of learning features to help students assimilate the information presented quickly and effectively. It will be relevant to undergraduate students on a wide variety of biomedical pathways, cutting across traditional discipline boundaries to provide a unified ovTable of ContentsIntroduction 1: Sample preparation 2: The molecular laboratory 3: Intact sample analysis 4: Homogenate sample analysis 5: Sequencing technologies 6: Molecular analysis and interpreting molecular data 7: Recent technical advances in molecular analysis 8: Haemopoietic diseases 1 - leukaemias 9: Haemopoietic diseases 2 - lymphoproliferative disorders 10: Breast cancer 11: Epithelial tumours and melanoma 12: Mesenchymal tumours 13: Pre-natal and neo-natal testing
£47.99
Royal Society of Chemistry Extracellular and Intracellular Signaling
a huge range and FREE tracked UK delivery on ALL orders.
£126.34
Wolters Kluwer Health BRS Physiology
Book SynopsisThe leading physiology review on the market, BRS Physiology, 8th Edition, delivers a concise, highly efficient review of all essential physiology concepts students encounter in the first and second year of medical school, as well as more than 350 clinical vignette-style, multiple-choice questions to help them prepare for course exams and practice for the USMLE Step 1. This bestselling title in the Board Review Series is preferred by students for its comprehensive yet efficient approach to exam prep and trusted by instructors for author Linda S. Costanzo’s masterful approach, communicating complex physiology concepts in an accessible manner. Extensively updated and incorporating abundant illustrations, flow charts, tables, and a comprehensive practice exam, this 8th Edition equips today’s students with the unparalleled preparation and confidence to excel on exams and beyond. Study efficiently with a concise outline format that makes essential information easy to review at a glance. Prepare for course and board exams with topical chapter questions and a 100-question Comprehensive Exam, accompanied by complete answers, rationales, and cross-references for efficient remediation. More than 260 multiple-choice questions in chapter exams test students’ understanding of chapter content; detailed explanations provide an additional learning tool. Build long-term retention with more than 120 full-color illustrations and charts that clarify complex information, as well as 50 detailed tables. Reference essential information conveniently with appendices on Key Physiology Topics for the USMLE Step 1, Key Physiology Equations for the USMLE Step I, and Normal Blood Values. Create connections between physiology knowledge and clinical medicine with new Clinical Correlation boxes.
£38.48
F.A. Davis Company Heme Notes 1e a Pocket Atlas of Cell Morphology
Book SynopsisThis pocket-sized atlas delivers concise, yet comprehensive coverage of the morphology of normal and abnormal peripheral blood and bone marrow cells. Organized by cell line, it emphasizes morphological identification. With more than 300 colour photographs, this is the perfect reference at the bench, in class, or during clinical rotations.Table of Contents Tab 1. The Peripheral Blood Smear and the Differential Tab 2. Erythropoiesis Tab 3. Leukopoiesis Tab 4. Red Blood Cell (RBC) Disorders Tab 5. White Blood Cell (WBC) Disorders: Benign Tab 6. White Blood Cell (WBC) Disorders: Malignant Tab 7. Platelet Disorders Tab 8. Normal Values
£35.10
Nova Science Publishers Inc Stem Cells from Culture Dish to Clinic
Book Synopsis
£195.19
Nova Science Publishers Inc Focus on Cell Apoptosis Research
Book SynopsisApoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This programmed cell death plays a critical role in physiological functions such as cell deletion during embryonic development, balancing cell number in continuously renewing tissues and immune system development. Additionally, a dysregulation of apoptosis is underlying in numerous pathological situations such as Parkinson, Alzheimer''s disease and cancer. A number of studies have pointed out an association between consumption of fruits and vegetables, and certain beverages such as tea and wine, which are rich in polyphenols, with reduced risk of chronic diseases, including cancer. Apoptosis is also the regulatory mechanism involved in the removal of unnecessary cells during development and in tissue homeostasis in a wide range of organisms from insects to mammals. The aim of this book is to provide untouched studies in this new and exciting field.
£176.24
Nova Science Publishers Inc Cellular Signaling & Apoptosis Research
Book SynopsisApoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This programmed cell death plays a critical role in physiological functions such as cell deletion during embryonic development, balancing cell number in continuously renewing tissues and immune system development. Additionally, a dysregulation of apoptosis is underlying in numerous pathological situations such as Parkinson, Alzheimer''s disease and cancer. A number of studies have pointed out an association between consumption of fruits and vegetables, and certain beverages such as tea and wine, which are rich in polyphenols, with reduced risk of chronic diseases, including cancer. Apoptosis is also the regulatory mechanism involved in the removal of unnecessary cells during development and in tissue homeostasis in a wide range of organisms from insects to mammals. This book focuses on cell apoptotic signalling.
£176.24
Oxford University Press Biophysics of Computation
Book SynopsisNeural network research often builds on the fiction that neurons are simple linear threshold units, completely neglecting the highly dynamic and complex nature of synapses, dendrites, and voltage-dependent ionic currents. Biophysics of Computation: Information processing in single neurons challenges this notion, using richly detailed experimental and theoretical findings from cellular biophysics to explain the repertoire of computational functions available to single neurons. The author shows how individual nerve cells can multiply, integrate, or delay synaptic inputs and how information can be encoded in the voltage across the membrane, in the intracellular calcium concentration, or in the timing of individual spikes.Key topics covered include the linear cable equation; cable theory as applied to passive dendritic trees and dendritic spines; chemical and electrical synapses and how to treat them from a computational point of view; nonlinear interactions of synaptic input in passive anTable of Contents1. The membrane equation ; 2. Linear cable theory ; 3. Passive dendritic trees ; 4. Synaptic input ; 5. Synaptic interactions in a passive dendritic tree ; 6. The Hodgkin-Huxley model of action-potential generation ; 7. Phase space analysis of neuronal excitability ; 8. Ionic channels ; 9. Beyond Hodgkin and Huxley: calcium, and calcium-dependent potassium currents ; 10. Linearizing voltage-dependent currents ; 11. Diffusion, buffering, and binding ; 12. Dendritic spines ; 13. Synaptic plasticity ; 14. Simplified models of individual neurons ; 15. Stochastic models of single cells ; 16. Bursting cells ; 17. Input resistance, time constants, and spike initiation ; 18. Synaptic input to a passive tree ; 19. Voltage-dependent events in the dendritic tree ; 20. Unconventional coupling ; 21. Computing with neurons - a summary
£91.20
OUP USA In Defense of Self
Book SynopsisIn Defense of Self introduces some of most important medical advances of the past hundred years, from the development of vaccines and the treatment of allergies, autoimmunity and cancer, to prolonging organ transplants and combating AIDS. It not only explains how a vital part of our bodies works, but also provides background for continuing research.Table of ContentsPART I: HOW THE IMMUNE SYSTEM WORKS; PART II THE IMMUNE SYSTEM IN HEALTH AND DISEASE
£15.99
Springer Handbook of Neurochemistry and Molecular Neurobiology
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£233.39
Springer Handbook of Neurochemistry and Molecular Neurobiology
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£208.82
Cambridge University Press Methods in Molecular Biophysics Structure
Book SynopsisCurrent techniques for studying biological macromolecules and their interactions are based on the application of physical methods, ranging from classical thermodynamics to more recently developed techniques for the detection and manipulation of single molecules. Reflecting the advances made in biophysics research over the past decade, and now including a new section on medical imaging, this new edition describes the physical methods used in modern biology. All key techniques are covered, including mass spectrometry, hydrodynamics, microscopy and imaging, diffraction and spectroscopy, electron microscopy, molecular dynamics simulations and nuclear magnetic resonance. Each method is explained in detail using examples of real-world applications. Short asides are provided throughout to ensure that explanations are accessible to life scientists, physicists and those with medical backgrounds. The book remains an unparalleled and comprehensive resource for graduate students of biophysics and Trade ReviewReview of first edition: '… a valuable contribution to the field. … There is nothing quite like it at the moment.' Sir Tom Blundell FRS, University of CambridgeReview of first edition: … one of the most comprehensive and highly relevant texts on biophysics that I have encountered in the last 10 years, clearly written and up-to-date … a must-have for biophysicists working in all lines of research …' Nikolaus Grigorieff, Brandeis University, MassachusettsReview of first edition: '… a wonderful up-to-date treatise on the many and diverse methods used … in the fields of molecular biophysics, physical biochemistry, molecular biology, biological physics and the new and emerging field of quantum nanobiology.' Karl J. Jalkanen, Quantum Protein Centre, Technological University of DenmarkReview of first edition: '… a valuable resource for novice and seasoned biophysicists alike.' Dan Minor, California Institute for Quantitative Biomedical Research, University of CaliforniaReview of first edition: '… the book I consult first when faced with an unfamiliar experimental technique. Both classic analytical techniques and the latest single-molecule methods appear in this single comprehensive reference.' Philip Nelson, University of Pennsylvania and author of Biological PhysicsReview of first edition: '… valuable both for students and research scientists.' Michael G. Rossmann, Hanley Professor of Biological Sciences, Purdue UniversityReview of first edition: 'A great achievement … awaits the student who reads this book … an excellent reference for the seasoned practitioner of biophysical chemistry.' Milton H. Werner, The Rockefeller UniversityReview of first edition: 'This well written, thorough, and elegantly illustrated book provides the connections between molecular biophysics and biology that every aspiring young biologist needs.' Stephen H. White, University of California at IrvineReview of first edition: '… I enthusiastically recommend Methods in Molecular Biophysics to anyone who wishes to know more about the techniques by which the properties of biological macromolecules are determined.' David Worcester, University of MissouriReview of first edition: 'A book that teaches the methods well, creates the intellectual framework of our understanding, and can guide the field. Earlier efforts by Cohn and Edsall, Tanford, Edsall and Wyman, and Cantor and Schimmel have served this important purpose in the past, but the advance of time and technology has diluted the force of these classic works in contemporary Biophysics, both in the teaching and the practices of the field. How welcome, then, a clearly written, thoughtful and modern text that will serve well, both in formal courses and as a reference. The authors have built each method from its fundamental premises and principles, have successfully covered an impressive span of topics, and will be rewarded by attention from an audience that hungers for the next defining text in Molecular Biophysics.' D. M. Engelman, Yale University, New HavenTable of ContentsPreface to the first edition; Preface to the second edition; Introduction; Part I. Biological Macromolecules and Physical Tools: 1. Macromolecules in their environment; 2. Macromolecules as physical particles; 3. Understanding macromolecular structures; Part II. Mass Spectrometry: 4. Mass and charge; 5. Structure function studies; Part III. Thermodynamics: 6. Thermodynamic stability and interactions; 7. Differential scanning calorimetry; 8. Isothermal titration calorimetry; 9. Surface plasmon resonance and interferometry-based biosensors; Part IV. Hydrodynamics: 10. Biological macromolecules as hydrodynamic particles; 11. Analytical ultracentrifugation; 12. Fluorescence depolarization; 13. Dynamic light scattering and fluorescence correlation spectroscopy; Part V. Optical Spectroscopy: 14. Visible and IR absorption spectroscopy; 15. Two-dimensional IR spectroscopy; 16. Raman scattering spectroscopy; 17. Optical activity and circular dichroïsm; Part VI. Optical Microscopy: 18. Light microscopy; 19. Single molecule manipulation and atomic force microscopy; 20. Fluorescence microscopy; 21. Single-molecule detection; 22. Single-molecule manipulation; Part VII. X-Ray and Neutron Diffraction: 23. The macromolecule as a radiation scattering particle; 24. Small-angle scattering and reflectometry; 25. X-ray and neutron macromolecular crystallography; Part VIII. Electron Diffraction: 26. Electron microscopy; 27. Three-dimensional reconstruction from two-dimensional images; Part IX. Molecular Dynamics: 28. Energy and time calculations; 29. Neutron spectroscopy; Part X. Nuclear Magnetic Resonance: 30. Distances and angles from frequencies; 31. Experimental techniques; 32. Structure and dynamics studies; Part XI. Medical Imaging: 33. Radiology and positron emission tomography; 34. Ultrasound imaging; 35. Magnetic resonance imaging; References; Index of eminent scientists; Subject index.
£64.35
Taylor & Francis Inc IgE and AntiIgE Therapy in Asthma and Allergic
Book SynopsisExploring the role of Immunoglobulin-E (IgE) in human disease, this reference summarizes current research on the mechanisms and utilization of anti-IgE therapeutics in the treatment of IgE-mediated allergic disease, inflammation, and asthma-discussing the structural composition of high- and low-affinity IgE receptors, the airway cells that express these receptors, and the functional activity of IgE-FceRI and IgE-FceRII interactions for improved control and management of allergic disorders.Compiles previously unpublished data from the first extensive scientific investigations of Xolair!IgE and Anti-IgE Therapy in Asthma and Allergic Diseasereviews studies on the distribution of serum IgE levels of normal and asthmatic populations in developed regions of the world such as the United States, Canada, Scandinavia, New Zealand, and Europe offers novel methods for the design and formulation of monoclonal antibodies discusses the use of allergeTable of ContentsIntroduction James D. Reimann, Sharon Safrin, and Robert B. Fick, Jr.Understanding the Binding of IgE to Its High-Affinity Receptor and to an Anti-IgE AntibodyLeonard G. Presta and Robert L. ShieldsMediator Release from Basophils and Mast Cells and Its Relationship to FceRI Expression and IgE-Suppressing TherapiesDonald W. MacGlashan, Jr., John T. Schroeder, Lawrence M. Lichtenstein, Sarbjit S. Saini, and Bruce S. BochnerExpression of IgE Receptors on Eosinophils David Dombrowicz, André Capron, and Monique CapronEosinophil IgE Receptors: Controversy and Consensus Hirohito Kita and Cheryl R. AdolphsonMurine Models of Asthma: Caveats and Conclusions on the Contribution of IgE and Mast Cells to Allergic Inflammation, Airway Hyperresponsiveness, and Airflow ObstructionJeffrey S. Tepper and Daniel B. TumasRole of IgE in Asthma: Pathogenesis and Novel Therapeutic StrategiesJames Laurence Lordan, Stephen T. Holgate, and Ian SayersIgE-Mediated Response to Allergen in the Bronchoprovocation LaboratoryLouis-Philippe Boulet and Donald W. CockcroftPathophysiology of the Airway Response to Inhaled Allergen in Asthmatic Subjects: Role of IgEJohn V. FahyEfficacy and Safety of Xolair Anti-IgE Monoclonal Antibody in Adult AsthmaticsRobert B. Fick, Jr., and W. James MetzgerThe Role of IgE in Pediatric Asthma Henry Milgrom and Charles JohnsonAnti-inflammatory Activities of Omalizumab (Xolair), a Recombinant Humanized Monoclonal Antibody Binding IgERobert B. Fick, Jr.Pulmonary Delivery of Anti-IgE: Rationale for Topical Delivery to the AirwayTheresa D. Sweeney, Melinda Marian, Jane Ruppel, and Jeanine L. BussiereTreatment of Seasonal Allergic Rhinitis Thomas B. Casale and Patricia W. RohaneAnti-IgE and Allergic Skin Diseases Michaël F. Hofer and Donald Y. M. LeungRole of IgE and Food Allergens Ricki M. Helm and A. Wesley BurksRole of IgE in Allergic Bronchopulmonary Aspergillosis Priscilla S. A. Sarinas and Rajinder K. ChitkaraIgE and Its Role in Parasitic Helminth Infection: Implications for Anti-IgE-Based TherapiesPhilip J. Cooper and Thomas B. NutmanThe Rise of Antibodies as Therapeutics Maureen P. Quan and Paul CarterAuthor Index
£166.25
Taylor & Francis Inc Human Longevity
Book SynopsisMore than 7 billion people inhabit the earth and all of them are subject to aging. This book is aimed at persons interested in a molecular explanation of how our cells age. Human Longevity: Omega-3 Fatty Acids, Bioenergetics, Molecular Biology, and Evolution is built on the proposition that we age as our mitochondria age. It suggests a revised version of Harman's famous hypothesis featuring mitochondrial oxidative and energy stresses as the root causes of aging. Human cells are protected from the ravages of aging by a battery of defensive systems including some novel mechanisms against membrane oxidation introduced in this book. This concept is consistent with recent discoveries showing that mitochondria-targeted antioxidants prevent Huntington's disease, Parkinson's disease, and traumatic brain disease in animal models of neurodegeneration.This book explores a unified theory of aging based on bioenergetics. It covers a variety of topics including Table of ContentsIntroduction to the Science of Human Aging. Darwinian Selection of Membranes Enabling Longevity. Revised Mitochondrial Membrane Hypothesis of Aging. Many Mechanisms Have Evolved to Protect Human Mitochondrial Membranes, Enabling Longevity.
£171.00
John Wiley & Sons Inc Chronic Obstructive Pulmonary Disease
Book SynopsisChronic obstructive pulmonary disease (COPD), characterized by progressive chronic airflow obstruction, is the most common respiratory disorder of adults in the developed world and is the fourth main cause of death in the US. COPD has received little attention compared with other respiratory diseases such as asthma and lung cancer.Trade Review"The panel of speakers included some of the most distinguished scientists and physicians working in the field of COPD." (Biochemie, No. 83, 2001)Table of ContentsOverview of the pathology/pathogenesis Overview of current therapies Genetics Mucus hypersecretion in COPD Mechanisms of exacerbation Epithelial and mesenchymal cells Macrophage control of inflammation: negative pathways of regulation of inflammatory cytokines Neutrophils Lymphocytes Oxidants/antioxidants Proteases and anti-proteases - I Proteases and anti-proteases - II Alveolus formation: critical period, plasticity and retinoid regulation Systemic effects of COPD Potential novel therapies for COPD
£137.66
Harvard University Press Cancer Stem Cells
Book SynopsisA new therapeutic strategy could break the stalemate in the war on cancer by targeting not all cancerous cells but the small fraction that lie at the root of cancers. Lucie Laplane offers a comprehensive analysis of cancer stem cell theory, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy.Trade ReviewLaplane places us right in the center of an urgently important discussion of cancer stem cells and the therapies that should accompany different theories. Her fresh philosophical perspective introduces us to a science in process, where the outcome is unknown and even the terms of debate remain contested. -- Jane Maienschein, author of Embryos under the MicroscopeIf you had doubts about the utility of philosophy for science, read this book. Its lucid exploration of stem cells will convince you that even cancer therapy can benefit from the lights of philosophy. -- Michel Morange, author of A History of Molecular BiologyBuilds a much broader framework for understanding the biology of stem cells of all types…Laplane’s rigorous analyses unveil deep semantic and conceptual problems in the field…Laplane’s stemness framework should be of great value…A philosopher may indeed have straightened out the stem-cell field. -- Hans Clever * Nature *
£31.41
John Wiley and Sons Ltd The Biology and Therapeutic Application of
Book SynopsisThe Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues. Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models Discusses the current status of mesenchymal stem and stromal cells in clinical trials iTable of ContentsContributors, xxvii Editor’s Preface, xxxv Section I: An overview of mesenchymal stem cells and mesenchymal stromal cells 1 The mesenchymal stem cell, the mesenchymal stromal cell, and the mesenchymal stromal cell exosome, 3Kerry Atkinson 2 The nomenclature of mesenchymal stem cells and mesenchymal stromal cells, 8Armand Keating Section II: The isolation and ex vivo expansion of mesenchymal stromal cells 3 The isolation and expansion of mesenchymal stromal cells from bone marrow, 13Celena F. Heazlewood 4 The biology and clinical applications of mesenchymal stromal cells derived from human gestational tissues, 24Celena F. Heazlewood 5 Human placenta-derived mesenchymal stem/stromal cells: fetal and maternal origins and critical parameters forex vivo expansion, 32Rebecca A. Pelekanos and Varda S. Sardesai Section III: The cellular and molecular biology of mesenchymal stromal cells 6 Epigenetic regulation of mesenchymal stem/stromal cell growth and multipotentiality, 41Sarah Elizabeth Hemming, Dimitrios Cakouros, and Stan Gronthos 7 Biological changes in human mesenchymal stromal cells during monolayer culture, 58Marietta Herrmann and Jennifer J. Bara 8 The effect of three-dimensional aggregates on the biology of mesenchymal stromal cells, 75Yijun Liu, Ang-Chen Tsai, Xuegang Yuan, and Teng Ma 9 Cell–cell signaling pathways that regulate mesenchymal stromal cell differentiation, 91Leah Etheridge, Rebecca A. Mason, Fatima Saleh, and Paul Genever 10 Regulation of mitochondrial transport in mesenchymal stromal cells, 104Shravani Mukherjee, Naveen K. Bhatraju, Tanveer Ahmad, and Anurag Agrawal 11 The regulation of adipogenesis from adipose-derived stem/stromal cells, 114Lin Chen and Lei Liu 12 Modulation of osteogenic differentiation in mesenchymal stromal cells, 131Sean Gaynard, Jessica Hayes, and Mary Murphy 13 The role of glycogen synthase kinase-3 inhibitors on bone remodeling, 148K. Jane Escott and Patrick J. O’Shea 14 Early molecular events during in vitro chondrogenesis, 167Tommy A. Karlsen, Rune B. Jakobsen, and Jan E. Brinchmann 15 The role of the extracellular matrix in the differentiation of mesenchymal stromal cells, 191Peishun Shou, Qing Chen, and Yufang Shi 16 Effects of hypoxic culture on bone marrow multipotent mesenchymal stromal cells: from bench to bedside, 196Shih-Chieh Hung 17 The role of cyclic tensile strain on osteogenesis and angiogenesis in human mesenchymal stem/stromal cells, 208Adisri Charoenpanich, Josephine Bodle, and Elizabeth Loboa 18 The evolving concept of mesenchymal stromal cells in regenerative medicine: from cell differentiation tosecretome, 222F.G. Teixeira, A. Pires, S.C. Serra, N. Sousa, and A.J. Salgado 19 The secretome of mesenchymal stem/stromal cells undergoing chondrogenic differentiation and those undergoing osteogenic or adipogenic differentiation, 236Beatriz Rocha, Francisco J. Blanco, and Cristina Ruiz-Romero 20 Mesenchymal stromal cell extracellular vesicles/exosomes, 250Ronne Wee Yeh Yeo, Ruenn Chai Lai, and Sai Kiang Lim 21 Role of tunneling nanotube crosstalk with distressed cardiomyocytes in controlling the heart repair potential of mesenchymal stromal cells, 264Anne-Marie Rodriguez and Meriem Mahrouf-Yorgov 22 The preferential homing of mesenchymal stromal cells to sites of inflammation, 286Catherine Sullivan 23 The role of chemokines in mesenchymal stromal cell homing to sites of inflammation, including infarctedmyocardium, 314Shan Wang and Yaojiong Wu 24 Live cell imaging and single cell tracking of’mesenchymal stromal cells in vitro, 323James A. Cornwell, Maria Z. Gutierrez, Richard P. Harvey and Robert E. Nordon 25 The role of mesenchymal stem/stromal cells in angiogenesis, 347Annelies Bronckaers and Ivo Lambrichts 26 The relationship between mesenchymal stromal cells and endothelial cells, 366Seyed Mahdi Nassiri and Reza Rahbarghazi 27 The radioresistance of mesenchymal stromal cells and their potential role in the management of radiation injury, 391Tara Sugrue, Irene Calvo-Asensio, and Rhodri Ceredig 28 The implications of multipotent mesenchymal stromal cells in tumor biology and therapy, 415Pratika Y. Hernanda, Maikel P. Peppelenbosch, and Qiuwei Pan 29 Mesenchymal stem/stromal cell therapy: mechanism of action and host response, 426Aideen Ryan, Mary Murphy, and Frank Barry 30 The differences between mesenchymal stromal cells and fibroblasts, 441Luigi Balducci, Sharon Natasha Cox, and Giulio Alessandri 31 Derivation of mesenchymal stem/stromal cells from induced pluripotent stem cells, 456Rebecca A. Pelekanos 32 The role of mesenchymal stem cells in hematopoiesis, 467Jean-Pierre Levesque, Rebecca N. Jacobsen, and Ingrid G. Winkler 33 The modulatory effects of mesenchymal stromal cells onthe innate immune system, 481Ko-Jiunn Liu, Men-Luh Yen, Li-Tzu Wang, and B. Linju Yen 34 The modulatory effects of mesenchymal stromal cells on the adaptive immune system, 490B. Linju Yen, Ko-Jiunn Liu, Men-Luh Yen, and Huey-Kang Sytwu 35 The role of mesenchymal stromal cells in the repair of acute organ injury, 496A.A. Temnov, A.V. Vagabov, A.N. Sklifas, V.I. Novoselov, and Y.A. Belyi 36 The use of mesenchymal stromal cells in the treatment of diseases of the cornea, 524Damien G. Harkin, Allison J. Sutherland, Laura J. Bray, Leanne Foyn, Fiona J. Li, and Brendan G. Cronin 37 The role of paracrine factors secreted by mesenchymal stromal cells in acute tissue injury, 544Ying Wang, Tania Velletri, Chunxing Zheng, and Yufang Shi 38 Treatment of lung disease by mesenchymal stromal cell extracellular vesicles, 553Antoine Monsel, Ying-gang Zhu, Varun Gudapati, and Jae-Woo Lee 39 Evaluating mesenchymal stem/stromal cells for treatment of asthma and allergic rhinitis, 573Tatyana Gavrilova, Saritha Kartan, Lauren S. Sherman, Oleta A. Sandiford, and Pranela Rameshwar 40 Stem cell therapies for Huntington’s disease, 581A.T. Crane, J. Rossignol, and G. L. Dunbar Section IV: The role of bioengineering in the therapeutic applications of mesenchymal stromal cells 41 Endometrial mesenchymal stromal cell and tissue engineering for pelvic organ prolapse repair, 601Shanti Gurung, Jerome A. Werkmeister, and Caroline E. Gargett 42 Closed automated large-scale bioreactors for manufacturing mesenchymal stromal cells for clinical use, 616Kerry Atkinson, Nicholas Timmins, G. Kiel, Celena Heazlewood, Michael Doran, and Gary Brooke Section V: GMP manufacturing of mesenchymal stromal cells for clinical use 43 Current good manufacturing practice for the isolation and ex vivo expansion of mesenchymal stromal cells derived from term human placenta for use in clinical trials, 621Kerry Atkinson, Dahlia Khalil, Celena Heazlewood, and Nina Ilic 44 A comparison of high-tier regulatory documents pertaining to biologic drugs including mesenchymal stromal cells in Australia, Europe, and the USA using a manual documentary analysis, 628Nina Ilic Section VI: The therapeutic application of mesenchymal stromal cells 45 The use of mesenchymal stromal cells in acute and chronic heart disease, 647Ariel Wolf, Wayne Balkan, and Joshua Hare 46 The role of mesenchymal stem/stromal cells in the management of critical limb ischemia, 661P.K. Gupta, Chullikana Anoop, Balasubramanian Sudha, R Mathiazhagan, Raj Swathi Sundar, and Majumdar Anish Sen 47 The role of mesenchymal stromal cells in the management of musculoskeletal disorders, 677Stefan Zwingenberger, Ishaq Ojodu, Maik Stiehler, and Stuart B. Goodman 48 The potential role of bone marrow mesenchymal stromal cells in the treatment of ischemic stroke, 690Yujun Pan and Ruohan Sun 49 The role of mesenchymal stromal cells in spinal cord injury, 714P. Jendelova, L. Machova-Urdzikova, and E. Sykova 50 The role of mesenchymal stromal cells in the treatment of ulcerative colitis and Crohn’s disease, 730Céline Gregoire, Chantal Lechanteur, Alexandra Briquet, Etienne Baudoux, Olivier Giet, Olivier Delloye, Frédéric Baron, Edouard Louis, and Yves Beguin 51 Mesenchymal stromal cells targeting kidney disease: benefits of a combined therapeutic approach, 754Brooke M. Huuskes and Sharon D. Ricardo 52 The biology and potential clinical applications of mesenchymal stromal cells in diseases of the lung, 770Yuben P. Moodley, Jesse D. Armitage, and Dino B.A. Tan 53 The role of mesenchymal stromal cells in diseases of the lung, 787Kerry Atkinson 54 Mesenchymal stromal cells for the treatment of’autoimmune diseases, 794Christopher N. Lewis and Jacques Galipeau 55 The role of mesenchymal stromal cells in bacterial infection, 814Sailaja Ghanta, Konstantin Tsoyi, and Mark A. Perrella 56 The use of mesenchymal stromal cells in solid organ transplantation, 825Céline Gregoire, Alexandra Briquet, François Jouret, Chantal Lechanteur, Etienne Baudoux, Olivier Giet, Olivier Delloye, Frédéric Baron, Olivier Detry, and Yves Beguin 57 The role of mesenchymal stromal cells in allogeneic hematopoietic stem cell transplantation, 836Kerry Atkinson 58 The role of mesenchymal stromal cells in the management of skin wounds, 841Sung-Whan Kim 59 The role of mesenchymal stromal cells in skin wound healing, 845Miao Teng and Hengshu Zhang Section VII: Mesenchymal stromal cells as delivery vehicles for therapeutic agents 60 The role of mesenchymal stromal cells in human brain tumors, 859Brittany C. Parker Kerrigan, Tal Shahar, Shinji Yamashita, and Frederick F. Lang 61 Mesenchymal stromal cells as gene delivery vehicles to treat nonmalignant diseases, 873Julie R. Beegle, Jan A. Nolta, and Fernando A. Fierro 62 Gene therapy for cancer using mesenchymal stromal cells, 892Ryosuke Uchibori and Keiya Ozawa Section VIII: The present and the future 63 Breaking news, 901Kerry Atkinson 64 Reconciling the stem cell and paracrine paradigms of mesenchymal stem cell function, 912Siddaraju V. Boregowda and Donald G. Phinney Glossary, 927 Index, 949
£371.66
John Wiley and Sons Ltd Cellular Physiology of Nerve and Muscle
Book SynopsisCellular Physiology of Nerve and Muscle, Fourth Edition offers a state of the art introduction to the basic physical, electrical and chemical principles central to the function of nerve and muscle cells. The text begins with an overview of the origin of electrical membrane potential, then clearly illustrates the cellular physiology of nerve cells and muscle cells. Throughout, this new edition simplifies difficult concepts with accessible models and straightforward descriptions of experimental results. An all-new introduction to electrical signaling in the nervous system. Expanded coverage of synaptic transmission and synaptic plasticity. A quantitative overview of the electrical properties of cells. New detailed illustrations. Table of ContentsPart I: Origin of Electrical Membrane Potential. 1. Introduction to Electrical Signaling in the Nervous System. The Patellar Reflex as a Model for Neural Function. The Cellular Organization of Neurons. Electrical Signals in Neurons. Transmission between Neurons. 2. Composition of Intracellular and Extracellular Fluids. Intracellular and Extracellular Fluids. The Structure of the Plasma Membrane. Summary. 3. Maintenance of Cell Volume. Molarity, Molality, and Diffusion of Water. Osmotic Balance and Cell Volume. Answers to the Problem of Osmotic Balance. Tonicity. Time-Course of Volume Changes. Summary. 4. Membrane Potential: Ionic Equilibrium. Diffusion Potential. Equilibrium Potential. The Nernst Equation. The Principle of Electrical Neutrality. The Cell Membrane as an Electrical Capacitor. Incorporating Osmotic Balance. Donnan Equilibrium. A Model Cell That Looks Like a Real Animal Cell. The Sodium Pump. Summary. 5. Membrane Potential: Ionic Steady State. Equilibrium Potentials for Sodium, Potassium, and Chloride. Ion Channels in the Plasma Membrane. Membrane Potential and Ionic Permeability. The Goldman Equation. Ionic Steady State. The Chloride Pump. Electrical Current and the Movement of Ions Across Membranes. Factors Affecting Ion Current Across a Cell Membrane. Membrane Permeability vs. Membrane Conductance. Behavior of Single Ion Channels. Summary. Part II: Cellular Physiology of Nerve Cells. 6. Generation of Nerve Action Potential. The Action Potential. Ionic Permeability and Membrane Potential. Measuring the Long-Distance Signal in Neurons. Characteristics of the Action Potential. Initiation and Propagation of Action Potentials. Changes in Relative Sodium Permeability During an Action Potential. Voltage-Dependent Sodium Channels of the Neuron Membrane. Repolarization. The Refractory Period. Propagation of an Action Potential Along a Nerve Fiber. Factors Affecting the Speed of Action Potential Propagation. Molecular Properties of the Voltage-Sensitive Sodium Channel. Molecular Properties of Voltage-Dependent Potassium Channels. Calcium-Dependent Action Potentials. Summary. 7. The Action Potential: Voltage Clamp Experiments. The Voltage Clamp. Measuring Changes in Membrane Ionic Conductance Using the Voltage Clamp. The Squid Giant Axon. Ionic Currents Across an Axon Membrane Under Voltage Clamp. The Gated Ion Channel Model. Membrane Potential and Peak Ionic Conductance. Kinetics of the Change in Ionic Conductance Following a Step Depolarization. Sodium Inactivation. The Temporal Behavior of Sodium and Potassium Conductance. Gating Currents. Summary. 8. Synaptic Transmission at the Neuromuscular Junction. Chemical and Electrical Synapses. The Neuromuscular Junction as a Model Chemical Synapse. Transmission at a Chemical Synapse. Presynaptic Action Potential and Acetylcholine Release. Effect of ACh on the Muscle Cell. Neurotransmitter Release. The Vesicle Hypothesis of Quantal Transmitter Release. Mechanism of Vesicle Fusion. Recycling of Vesicle Membrane. Inactivation of Released Acetylcholine. Recording the Electrical Current Flowing Through a Single Acetylcholine-Activated Ion Channel. Molecular Properties of the Acetylcholine-Activated Channel. Summary. 9. Synaptic Transmission in the Central Nervous System. Excitatory and Inhibitory Synapses. Excitatory Synaptic Transmission Between Neurons. Temporal and Spatial Summation of Synaptic Potentials. Some Possible Excitatory Neurotransmitters. Conductance-Decrease E.P.S.P.'s. Inhibitory Synaptic Transmission. The Synapse Between Sensory Neurons and Antagonist Neurons in the Patellar Reflex. Characteristics of Inhibitory Synaptic Transmission. Mechanism of Inhibition in the Postsynaptic Membrane. Some Possible Inhibitory Neurotransmitters. The Family of Neurotransmitter-Gated Ion Channels. Neuronal Integration. Indirect Actions of Neurotransmitters. Presynaptic Inhibition and Factilitation. Synaptic Plasticity. Short-Term Changes in Synaptic Strength. Long-Term Changes in Synaptic Strength. Summary. Part III: Cellular Physiology of Muscle Cells. 10. Excitation-Contraction Coupling in Skeletal Muscle. The Three Types of Muscle. Structure of Skeletal Muscle. Changes in Striation Pattern on Contraction. Molecular Composition of Filaments. Interaction Between Myosin and Actin. Regulation of Contraction. The Sarcoplasmic Reticulum. The Transverse Tubule System. Summary. 11. Neural Control of Muscle Contraction. The Motor Unit. The Mechanics of Contraction. The Relationship Between Isometric Tension and Muscle Length. Control of Muscle Tension by the Nervous System. Recruitment of Motor Neurons. Fast and Slow Muscle Fibers. Temporal Summation of Contractions Within a Single Motor Unit. Asynchronous Activation of Motor Units During Maintained Contraction. Summary. 12. Cardiac Muscle: The Autonomic Nervous System. Autonomic Control of the Heart. The Pattern of Cardiac Contraction. Coordination of Contraction Across Cardiac Muscle Fibers. Generation of Rhythmic Contractions. The Cardiac Action Potential. The Pacemaker Potential. Actions of Acetylcholine and Norepinephrine on Cardiac Muscle Cells. Summary. Appendix A: Derivation of the Nernst Equation. Appendix B: Derivation of the Goldman Equation. Appendix C: Electrical Properties of Cells. Suggested Readings
£62.65
Taylor & Francis Ltd Stem Cells and Bone Tissue
a huge range and FREE tracked UK delivery on ALL orders.
£58.89
Taylor & Francis Ltd Oxidative Eustress in Exercise Physiology
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£104.50
Cambridge University Press acyberneticviewofbiologicalgrowththemaiahypothesis
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Cambridge University Press Methodologies for Metabolomics
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John Wiley & Sons Inc Mitochondrial Biology
Book SynopsisFeaturing contributions from many of the leading laboratories of mitochondrial biology worldwide, Novartis Foundation Symposium 287, Mitochondrial Biology: New Perspectives provides a timely summary of the current state-of-the-art in mitochondrial research.Table of ContentsSymposium on New perspectives on mitochondrial biolog y, held at the Novartis Foundation, London, 28–30 November 2006. Editors: Derek J. Chadwick (Organizer) and Jamie Goode. This symposium is based on a proposal by Michael Duchen. David G. Nicholls Chair's introduction. Albert Neutzner, Richard J. Youle and Mariusz Karbowski, Outer mitochondrial membrane protein degradation by the proteasome. Discussion. Sarah E. Haigh, Gilad Twig, Anthony A. J. Molina, Jakob D. Wikstrom, Motti Deutsch and Orian S. Shirihai PA-GFP: a window into the subcellular adventures of the individual mitochondrion. Discussion. Luca Scorrano, Multiple functions of mitochondria-shaping proteins. Discussion. Bruce M. Spiegelman, Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators. Discussion. Charles Affourtit, Paul G. Crichton, Nadeene Parker and Martin D. Brand, Novel uncoupling proteins. Discussion. Cecilia Giulivi, Mitochondria as generators and targets of nitric oxide. Discussion. György Hajnóczky, Masao Saotome, György Csordás, David Weaver and Muqing Yi, Calcium signalling and mitochondrial motility. Discussion. Anna Romagnoli, Paola Aguiari, Diego De Stefani, Sara Leo, Saverio Marchi, Alessandro Rimessi, Erika Zecchini, Paolo Pinton and Rosario Rizzuto, Endoplasmic reticulum/mitochondria calcium cross-talk. Discussion. Brian O’Rourke, Sonia Cortassa, Fadi Akar and Miguel Aon, Mitochondrial ion channels in cardiac function and dysfunction. Discussion. Paolo Bernardi and Michael Forte, The mitochondrial permeability transition pore. Discussion. Dominic James, Philippe A. Parone, Olivier Terradillos, Safa Lucken-Ardjomande, Sylvie Montessuit and Jean-Claude Martinou, Mechanisms of mitochondrial outer membrane permeabilization. Discussion. M. Flint Beal, Mitochondria and neurodegeneration. Discussion. Mügen Terzioglu and Nils-Göran Larsson, Mitochondrial dysfunction in mammalian ageing. Discussion. Eric A. Schon and Salvatore DiMauro. Mitochondrial mutations: genotype to phenotype. Discussion. Contributor Index. Subject index.
£150.05
