Cellular biology (cytology) Books
Springer Thermal Biology
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Cambridge University Press Los origenes de la vida
Book SynopsisHow did life on earth originate? Did replication or metabolism come first in the history of life? In this book, Freeman Dyson examines these questions and discusses the two main theories that try to explain how naturally occurring chemicals could organize themselves into living creatures. The majority view is that life began with replicating molecules, the precursors of modern genes. The minority belief is that random populations of molecules evolved metabolic activities before exact replication existed. Dyson analyzes both of these theories with reference to recent important discoveries by geologists and chemists. His main aim is to stimulate new experiments that could help to decide which theory is correct. This second edition covers the enormous advances that have been made in biology and geology in the past decade and the impact they have had on our ideas about how life began. It is a clearly-written, fascinating book that will appeal to anyone interested in the origins of life.
£10.89
Springer Oncothermia: Principles and Practices
Book SynopsisOncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless, hyperthermia has been wrought with significant controversy, mostly stemming from shortcomings of controlled energy delivery. Oncothermia has been able to overcome these insufficiencies and prove to be a controlled, safe and efficacious treatment option. This book is the first attempt to elucidate the theory and practice of oncothermia, based on rigorous mathematical and biophysical analysis, not centered on the temperature increase. It is supported by numerous in-vitro and in-vivo findings and twenty years of clinical experience. This book will help scientists, researchers and medical practitioners in understanding the scientific and conceptual underpinnings of oncothermia and will add another valuable tool in the fight against cancer. Professor Andras Szasz is the inventor of oncothermia and the Head of St Istvan University's Biotechnics Department in Hungary. He has published over 300 papers and lectured at various universities around the world. Dr. Oliver Szasz is the managing director of Oncotherm, the global manufacturer and distributor of medical devices for cancer treatment used in Europe & Asia since the late 1980s. Dr. Nora Szasz is currently a management consultant in healthcare for McKinsey & Co. Table of ContentsOBJECTIVE OF THE BOOK 1. ONCOLOGY – TREATMENTS AND THEIR LIMITS 1.1. CANCER – SHORT HISTORY AND EFFORTS TO CURE 1.1.1. Historical notes 1.1.2. The “war” against cancer 1.2. PARADIGM AND CHALLENGES OF ONCOTHERAPIES 1.3. LIMITATIONS OF ONCOTHERAPIES – QUEST FOR STEPS FORWARD 1.3.1. Medical challenge of oncotherapies 1.3.2. Ethical challenge of oncotherapies 1.3.3. Evaluation challenge of the results 2. HYPERTHERMIA RESULTS AND CHALLENGES 2.1. HYPERTHERMIA APPROACH 2.1.1. Definition of hyperthermia in oncology 2.1.2. Basic concepts of oncological hyperthermia 2.1.3. Technical variations of hyperthermia in oncology 2.2. EFFECTS OF HYPERTHERMIA 2.2.1. Higher baseline temperature 2.2.2. Vascular changes 2.2.3. Cellular membrane changes 2.2.4. Lactic acid formation 2.2.5. ATP depletion 2.2.6. Altered DNA replication 2.2.7. Enhanced immune reaction 2.2.8. Pain reduction 2.2.9. Selective gain of the heat-resistance 2.3. CLINICAL ONCOLOGICAL HYPERTHERMIA 2.3.1. Local and whole-body heating 2.3.2. Hyperthemia as a complementary method 2.4. HYPERTHERMIA SUCCESSES 2.4.1. Brain tumor treatments by hyperthermia 2.4.2. Pancreas tumor treatment by hyperthermia 2.4.3. Lung and bronchus 2.4.4. Hepatocellular carcinoma and metastatic tumors of liver 2.4.5. Colo-rectal tumors 2.4.6. Esophagus 2.4.7. Head and neck localizations 2.4.8. Gastric tumors 2.4.9. Breast tumors 2.4.10. Other localizations treated by hyperthermia 2.5. HYPERTHERMIA CHALLENGES IN ONCOLOGY 2.5.1. Challenge of selection and focus 2.5.2. Challenge of temperature 2.5.3. Medical challenges of hyperthermia in oncology 2.5.4. Challenge on quality control and dosimetry of hyperthermia 2.5.5. What we expect? 2.5.6. Possible solution: oncothermia 3. THERMO-BIO-PHYSICS 3.1. FACTORS OF PHYSIOLOGY HEATING 3.2. BIOTHERMODYNAMICS 3.2.1. Energy, heat and temperature 3.2.2. Energy of the chemical bonds and reactions 3.2.3. Energy sources and driving forces 3.2.4. Energy and structure 3.2.5. Energetics of malignant cells 3.2.6. “Non-thermal” effects – thermodynamial approach 3.3. BIOELECTRODYNAMICS 3.3.1. Basic interactions 3.3.2. The bioimpedance 3.3.3. “Nonthermal effects” – electrodynamical appraoch 3.3.4. “Non-thermal effects” – approach of electric currents 3.3.5. Membrane effects 3.3.6. Stochastic processes 3.3.7. Noises and signals 3.3.8. Resonances 3.3.9. Modulation-demodulation 3.3.10. Special field-effects of bio-systems 4. ONCOTHERMIA – NEW KIND OF ONCOLOGIC HYPERTHERMIA 4.1. ONCOTHERMIA CHARACTERISTICS 4.1.1. Electro Cancer Therapy (ECT) 4.1.2. Concept of oncothermia 4.1.3. Pennes equation revised 4.1.4. Thermal limit problem 4.1.5. Energy-transfer through the body surface 4.1.6. Penetration depth 4.1.7. Arrangement of electrodes 4.1.8. Far from equilibrium 4.1.9. Energy intake and temperature 4.1.10. Macroscopic focusing on the tumor 4.1.11. Heating the extracellular electrolyte 4.1.12. Temperature gradient and heat-flow on the membrane 4.1.13. Changes of the membrane potential 4.1.14. Membrane damage by constrained ion-currents 4.1.15. Effect on cell-cell connections 4.1.16. Oncotherm comparison 4.2. ONCOTHERMIA TREATMENT GUIDELINES 4.2.1. Treatment planning 4.2.2. Treatment consensus 4.3. COMPLEMENTARY APPLICATIONS 4.3.1. Complementary to radiotherapy 4.3.2. Complementary to chemotherapy 4.3.3. Clinical toxicity, safety 4.4. ONCOTHERMIA CASE REPORTS 4.4.1. Near eye treatments 4.4.2. Brain cases 4.4.3. Gynecology cases 4.4.4. Gastrointestinal cases 4.4.5. Pulmonary cases 4.4.6. Other cases 4.5. EVALUATION OF ONCOTHERMIA STUDIES 4.5.1. Evaluation conditions 4.5.2. Evaluation methods 4.6. GENERAL OVERVIEW ON A LARGE PATIENT’S POOL 4.7. BRAIN STUDIES 4.7.1. Brain safety study (Phase I) 4.7.2. Brain efficacy study (Phase II) 4.7.3. Hungarian brain glioma study 4.7.4. Small prospective, double arm brain glioma study 4.7.5. Study of brain gliomas with local clinical responses 4.7.6. Brain glioma study with relapses 4.7.7. Bicentral brain glioma study 4.7.8. Oncothermia for heavy pre-treated & relapsed brain gliomas 4.7.9. Study of metastatic brain tumors 4.7.10. Comparison of oncothermia brain studies 4.8. PANCREAS STUDIES 4.8.1. Pancreas efficacy study I. 4.8.2. Pancreas efficacy study II. (HTT) 4.8.3. Additional historical control to HTT pancreas study 4.8.4. Comparison of pancreas efficacy studies I. & II. 4.8.5. Pancreas efficacy study III. 4.8.6. Pancreas efficacy study IV. 4.8.7. Other oncothermia pancreas studies and their comparison 4.9. LUNG STUDIES 4.9.1. Oncothermia lung study I. 4.9.2. Oncothermia lung study II. 4.9.3. Meta-analysis of oncothermia lung studies 4.9.4. Compare to historical control 4.10. LIVER STUDIES 4.10.1. Study of liver metastases colorectal origine 4.10.2. Study of advanced liver metastases colorectal origine II. 4.10.3. Comparison study of treatment lines of colorectal liver metastases 4.10.4. Study of platinum derivatives with oncothermia for liver metastases from colorectal origine 4.10.5. Study of liver metastases rectal origine 4.10.6. Study of liver metastases various origine 4.10.7. Study of far advanced liver metastases various origines. Comparison of complementary therapies 4.11. COMPARISON OF STUDIES OF LIVER METASTASES 4.12. GYNECOLOGICAL (PELVIC) CANCER STUDY 4.12.1. Ovary study 4.12.2. Uterine corpus cancer 4.12.3. Uterine cervix 4.12.4. Comparison of oncothermia in pelvic gynecology 4.13. BREAST STUDY 4.14. ESOPHAGUS STUDY 4.14.1. Esophagus study I. 4.14.2. Esophagus study II. 4.15. STOMACH STUDY 4.16. COLO-RECTAL STUDIES 4.16.1. Preoperative oncothermia for rectum carcinoma 4.16.2. Colorectal carcinoma study 4.17. BONE STUDIES 4.17.1. Refractory bone metastases complementary to radiotherapy 4.17.2. Advanced bone metastases monotherapy 4.17.3. Osteosarcoma study 4.18. KIDNEY STUDY 4.19. HEAD AND NECK STUDY 4.20. URINARY BLADDER MALIGNANCIES 4.21. SOFT-TISSUE MALIGNANCIES 4.22. PROSTATE STUDY 4.23. ONCOTHERMIA PERSPECTIVES APPENDIX 1 ENTROPY AND TEMPERATURE APPENDIX 2 THERMODYNAMICS – ONSAGER’S RELATION APPENDIX 3 SELF-SIMILARITY AND BIOSCALING APPENDIX 4 ENERGY SUPPLY BY DEMANDS APPENDIX 5 ONCOGENIC GROWTH APPENDIX 6 BASIC BIOELECTROMAGNETICS APPENDIX 7 BIOIMPEDANCE OF CELLS & TISSUES APPENDIX 8 BOUNDARY CONDITIONS APPENDIX 9 DIRECT CURRENT APPLICATIONS APPENDIX 10 DEVELOPMENT OF EDEMA APPENDIX 11 WARBURG-IMPEDANCE APPENDIX 12 CELL-MEMBRANE PERMEABILITY APPENDIX 13 STOCHASTIC PROCESSES – PINK-NOISE APPENDIX 14 AUTOCORRELATION APPENDIX 15 DISSIPATIVE SYSTEMS APPENDIX 16 STOCHASTIC RESONANCE APPENDIX 17 RESONANCE OF ENZYMATIC REACTIONS APPENDIX 18 DEMODULATION BY STOCHASTIC RESONANCE APPENDIX 19 NON-LINEAR EFFECTS OF ENERGY-FLOW APPENDIX 20 PRINCIPLE OF MINIMAL ENERGY-DISPERSION APPENDIX 21 CHARGE-INHOMOGENETIES APPENDIX 22 PENNES’ EQUATION APPENDIX 23 PENNES’ EQUATION IS REVISED APPENDIX 24 SELF-FOCUSING APPENDIX 25 DYNAMISM OF TEMPERATURE ON THE MEMBRANE APPENDIX 26 CHANGES OF THE MEMBRANE-POTENTIAL APPENDIX 27 MEMBRANE DAMAGE BY INCREASING PRESSURE APPENDIX 28 DYNAMICS OF ADHERENT BONDS APPENDIX 29 MODULATION EFFECT APPENDIX 30 COMPONENTS OF CELL-DESTRUCTION APPENDIX 31 EXPERIMENTAL CONDITIONS IN VITRO APPENDIX 32 EXPERIMENTAL CONDITIONS IN VIVO APPENDIX 33 CONSIDERATIONS FOR EXPERIMENTAL SETUP IN VIVO APPENDIX 34 VALIDATION OF MORPHOLOGIC EVALUATION APPENDIX 35 EVALUATION OF SURVIVAL STUDY WITH SINGLE ARM 5. ACKNOWLEDGEMENT 6. REFERENCES
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Oxford University Press LEAF DEFENCE C
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Taylor & Francis Ltd Hox Modules in Evolution and Development
Book SynopsisFew, if any, genes have had the same level of impact on the field of evolutionary-developmental biology (evo-devo) as the Hox genes. These genes are renowned for their roles in patterning the body plans and development of the animal kingdom. This is complemented by the distinctive organisation of these genes in the genome, with them frequently being found as clusters in which gene position is linked to when and where the individual genes are expressed, particularly during embryogenesis. This book provides the latest overviews of Hox gene organisation and function for major clades of animals from across the animal kingdom. With the rapidly increasing availability of high-quality whole genome sequences from an ever-expanding range of species, it is becoming increasingly evident that there is great diversity in the organisation of Hox genes. These great strides in genome sequencing are wedded to important developments in our ability to detect expression and disrupt gene function in speTable of ContentsSeries Preface. Preface. About the Editor. Contributors. Introduction to Hox Modules in Evolution and Development. Multiple Layers of Complexity in the Regulation of the Bithorax Complex of Drosophila. The Role of Hox Genes in the Origins and Diversification of Beetle Horns. Duplication and Evolution of Hox Clusters in Chelicerata (Arthropoda). Structural Constraints in Hox Clusters: Lessons from Sharks and Rays. Evolution of Cyclostome Hox Clusters. Hox Genes in Echinoderms. Hox Genes in Mollusca. The Evolution of Hox Genes in Spiralia. Index.
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Taylor & Francis Ltd RNA the Epicenter of Genetic Information
Book SynopsisThe origin story and emergence of molecular biology is muddled. The early triumphs in bacterial genetics and the complexity of animal and plant genomes complicate an intricate history. This book documents the many advances, as well as the prejudices and founder fallacies. It highlights the premature relegation of RNA to simply an intermediate between gene and protein, the underestimation of the amount of information required to program the development of multicellular organisms, and the dawning realization that RNA is the cornerstone of cell biology, development, brain function and probably evolution itself. Key personalities, their hubris as well as prescient predictions are richly illustrated with quotes, archival material, photographs, diagrams and references to bring the people, ideas and discoveries to life, from the conceptual cradles of molecular biology to the current revolution in the understanding of genetic information.Key Features Documents the confused early history of DNA, RNA and proteins - a transformative history of molecular biology like no other. Integrates the influences of biochemistry and genetics on the landscape of molecular biology. Chronicles the important discoveries, preconceptions and misconceptions that retarded or misdirected progress. Highlights major pioneers and contributors to molecular biology, with a focus on RNA and noncoding DNA. Summarizes the mounting evidence for the central roles of non-protein-coding RNA in cell and developmental biology. Provides a thought-provoking retrospective and forward-looking perspective for advanced students and professional researchers. The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.Trade Review“Thrilling and provocative ... There is a need for such a book... There’s nothing quite like this out there.An epic tale of biology’s central molecule, RNA.DNA does only one thing, store information. RNA has a thrilling plethora of functions, including telling DNA what to do. This book takes the reader on an odyssey through the wonders of RNA and its central role in biology.DNA science dominated the second half of the 20th Century, but it’s clear that the 21st Century belongs to RNA. This long-overdue book reveals the diverse wonders of RNA in a series of thrilling and provocative stories.”Tom Cech, Nobel laureate, University of Colorado Boulder_____________________________________“The book is truly monumental and will be treasured by RNA scientists and others, as well. It beautifully captures the excitement and wonder that I have been lucky to experience working in the RNA field since the early 1960s.”Joan Steitz, Yale University_____________________________________“This book is really disruptive and presents a coherent view of our understanding of biology in terms of the genetic molecules, the nucleic acids, DNA and RNA. It covers an immense territory of molecular biology and its history of discoveries, all presented with a clear-cut intellectual thread.... It is very timely by its breadth and emphasis on the role of RNA in biology. It makes a strong case for RNA and its late acceptance... the fight uphill, like that of Sisyphus, was tough and demanded a lot of perseverance. It is really rather complete.”Eric Westhof, University of Strasbourg_____________________________________“The book is unique. It provides the long-overdue correction of the still widespread static views on evolution, development and genome organization and function. It has the potential to induce radical changes in widely held views and attitudes.”Peter Vogt, Scripps Research Institute, La Jolla_____________________________________"History is the key to our modern understanding of RNA. This magnum opus describes how science, scientific thought and landmark discoveries revealed the central role of RNA in molecular biology and evolution. The authors are not only modern pioneers of RNA science, but also the best histo-RNA-ians of our time.”John Rinn, University of Colorado, Boulder_____________________________________"RNA, the Epicenter of Genetic Information is much more than what its title might suggest. This epic book by Mattick and Amaral superbly reflects the continuing excitement about RNA research. It is not only a description of our current understanding of the role of RNA in cell and developmental biology but is also a useful history of molecular biology. Each of the eighteen chapters is a brilliantly written semi-autonomous essay on a particular segment of the RNA odyssey. I wholeheartedly recommend this book to anybody interested in the biology of RNA, in evolution, and in the organization and function of complex genomes." Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Basel_____________________________________"Those who might think that this book is only for the scientists, think again. It is not. It will appeal in equal measure to the thinking generalist and culturally curious interested in the thrilling history of molecular biology, the wonders of the long-overlooked central molecule RNA and its pivotal role in human development and evolution.An epic, provocative, and highly original book that highlights the way science is so often sidetracked by preconceptions and hubris, and explores the struggle to understand all that junk DNA we were told we had. The junk is not junk! The answers are all there. A story and a journey not to be missed!"Gabriel Farago (USA TODAY Bestselling author of the Jack Rogan Mysteries Series) Table of ContentsPreface, Chapter 1. Overview, Chapter 2. The genetic material?, Chapter 3. Halcyon days, Chapter 4. Worlds apart, Chapter 5. Strange genomes, strange genetics, Chapter 6. The Age of Aquarius, Chapter 7. All that junk, Chapter 8. The expanding repertoire of RNA, Chapter 9. Glimpses of a modern RNA world, Chapter 10. Genome sequences and transposable elements, Chapter 11. The human genome, Chapter 12. Small RNAs with mighty functions, Chapter 13. Large RNAs with many functions, Chapter 14. The epigenome, Chapter 15. The programming of development, Chapter 16. RNA and repeats rule, Chapter 17. Plasticity, Chapter 18. Beyond the jungle of dogmas, References
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