Biochemistry Books
Taylor & Francis Ltd From Proteins to Proteomics
a huge range and FREE tracked UK delivery on ALL orders.
£109.25
Taylor & Francis Ltd Nanozymes
a huge range and FREE tracked UK delivery on ALL orders.
£147.25
Taylor & Francis Ltd Basic Concepts in Environmental Biotechnology
a huge range and FREE tracked UK delivery on ALL orders.
£45.99
Taylor & Francis Ltd Toxic Metals Contamination
a huge range and FREE tracked UK delivery on ALL orders.
£128.25
Taylor & Francis Ltd Microbial Based Land Restoration Handbook Volume 2
a huge range and FREE tracked UK delivery on ALL orders.
£137.75
Taylor & Francis Ltd Microbial Based Land Restoration Handbook Volume 1
a huge range and FREE tracked UK delivery on ALL orders.
£137.75
Taylor & Francis Ltd An Introduction to Computational Systems Biology
Book SynopsisThis book delivers a comprehensive and insightful account of applying mathematical modelling approaches to very large biological systems and networksa fundamental aspect of computational systems biology. The book covers key modelling paradigms in detail, while at the same time retaining a simplicity that will appeal to those from less quantitative fields. Key Features: A hands-on approach to modelling Covers a broad spectrum of modelling, from static networks to dynamic models and constraint-based models Thoughtful exercises to test and enable understanding of concepts State-of-the-art chapters on exciting new developments, like community modelling and biological circuit design Emphasis on coding and software tools for systems biology Companion website featuringTrade ReviewThis is a very comprehensive read that provides a solid base in computational biology. The book is structured in 4 parts and 14 chapters which cover all the way from the more basic concepts to advanced material, including the state-of-the-art methodologies in synthetic and systems biology. This is a bedside book for those researchers embarking to do investigation in computational biology and a great office companion for anyone working on systems and synthetic biology. -- Rodrigo Ledesma Amaro, Lecturer, Imperial College London This is a fantastic book. It offers an elegant introduction to both classical and modern concepts in computational biology. To the uninitiated, it is a terrific first read, bringing alive the glory of the past and the promise of the future. To the interested, it handholds and offers a springboard to dive deep. To the practitioner, it serves as a valuable resource bringing together in a panoramic view many diverse streams that adorn the landscape. -- Narendra M. Dixit, Professor, Indian Institute of Science This is a very comprehensive read that provides a solid base in computational biology. The book is structured in 4 parts and 14 chapters which cover all the way from the more basic concepts to advanced material, including the state-of-the-art methodologies in synthetic and systems biology. This is a bedside book for those researchers embarking to do investigation in computational biology and a great office companion for anyone working on systems and synthetic biology. -- Rodrigo Ledesma Amaro, Lecturer, Imperial College London This is a fantastic book. It offers an elegant introduction to both classical and modern concepts in computational biology. To the uninitiated, it is a terrific first read, bringing alive the glory of the past and the promise of the future. To the interested, it handholds and offers a springboard to dive deep. To the practitioner, it serves as a valuable resource bringing together in a panoramic view many diverse streams that adorn the landscape. -- Narendra M. Dixit, Professor, Indian Institute of Science Table of ContentsPreface Introduction to modelling 1.1 WHAT IS MODELLING? 1.1.1 What are models? 1.2 WHYBUILD MODELS? 1.2.1 Why model biological systems? 1.2.2 Why systems biology? 1.3 CHALLENGES IN MODELLING BIOLOGICAL SYSTEMS 1.4 THE PRACTICE OF MODELLING 1.4.1 Scope of the model1.4.2 Making assumptions 1.4.3 Modelling paradigms 1.4.4 Building the model 1.4.5 Model analysis, debugging and (in)validation 1.4.6 Simulating the model 1.5 EXAMPLES OF MODELS 1.5.1 Lotka–Volterra predator–prey model 1.5.2 SIR model: a classic example 1.6 TROUBLESHOOTING 1.6.1 Clarity of scope and objectives 1.6.2 The breakdown of assumptions 1.6.3 Ismy model fit for purpose? 1.6.4 Handling uncertainties EXERCISES REFERENCES FURTHER READING Introduction to graph theory 2.1 BASICS 2.1.1 History of graph theory 2.1.2 Examples of graphs 2.2 WHYGRAPHS? 2.3 TYPES OF GRAPHS 2.3.1 Simple vs. non-simple graphs 2.3.2 Directed vs. undirected graphs 2.3.3 Weighted vs. unweighted graphs 2.3.4 Other graph types 2.3.5 Hypergraphs 2.4 COMPUTATIONAL REPRESENTATIONS OF GRAPHS 2.4.1 Data structures 2.4.2 Adjacency matrix 2.4.3 The laplacian matrix 2.5 GRAPH REPRESENTATIONS OF BIOLOGICAL NETWORKS 2.5.1 Networks of protein interactions and functional associations2.5.2 Signalling networks 2.5.3 Protein structure networks 2.5.4 Gene regulatory networks 2.5.5 Metabolic networks 2.6 COMMONCHALLENGES&TROUBLESHOOTING 2.6.1 Choosing a representation 2.6.2 Loading and creating graphs 2.7 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Structure of networks 3.1 NETWORK PARAMETERS 3.1.1 Fundamental parameters 3.1.2 Measures of centrality 3.1.3 Mixing patterns: assortativity 3.2 CANONICAL NETWORK MODELS 3.2.1 Erdos–Rényi (ER) network model 3.2.2 Small-world networks 3.2.3 Scale-free networks 3.2.4 Other models of network generation 3.3 COMMUNITY DETECTION 3.3.1 Modularity maximisation 3.3.2 Similarity-based clustering 3.3.3 Girvan–Newman algorithm 3.3.4 Other methods 3.3.5 Community detection in biological networks 3.4 NETWORKMOTIFS 3.4.1 Randomising networks 3.5 PERTURBATIONS TO NETWORKS 3.5.1 Quantifying e□fects of perturbation 3.5.2 Network structure and attack strategies 3.6 TROUBLESHOOTING 3.6.1 Is your network really scale-free? 3.7 SOFTWARE TOOLS EXERCISES REFERENCESFURTHER READING Applications of network biology 4.1 THE CENTRALITY–LETHALITY HYPOTHESIS 4.1.1 Predicting essential genes fromnetworks 4.2 NETWORKS AND MODULES IN DISEASE 4.2.1 Disease networks 4.2.2 Identification of disease modules 4.2.3 Edgetic perturbation models 4.3 DIFFERENTIAL NETWORK ANALYSIS 4.4 DISEASE SPREADING ON NETWORKS 4.4.1 Percolation-based models 4.4.2 Agent-based simulations 4.5 MOLECULAR GRAPHS AND THEIR APPLICATIONS 4.5.1 Retrosynthesis 4.6 PROTEIN STRUCTURE, ENERGY & CONFORMATIONAL NETWORKS4.6.1 Protein folding pathways 4.7 LINK PREDICTION EXERCISES REFERENCES FURTHER READING Introduction to dynamic modelling5.1 CONSTRUCTING DYNAMIC MODELS 5.1.1 Modelling a generic biochemical system 5.2 MASS-ACTION KINETIC MODELS 5.3 MODELLING ENZYME KINETICS 5.3.1 The Michaelis–Menten model 5.3.2 Extending the Michaelis–Menten model 5.3.3 Limitations of Michaelis–Menten models 5.3.4 Co-operativity: Hill kinetics 5.3.5 An illustrative example: a three-node oscillator 5.4 GENERALISED RATE EQUATIONS 5.4.1 Biochemical systems theory 5.5 SOLVING ODES 5.6 TROUBLESHOOTING 5.6.1 Handing sti□f equations 5.6.2 Handling uncertainty 5.7 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Parameter estimation 6.1 DATA-DRIVEN MECHANISTIC MODELLING: AN OVERVIEW 6.1.1 Pre-processing the data 6.1.2 Model identification 6.2 SETTING UP AN OPTIMISATION PROBLEM 6.2.1 Linear regression 6.2.2 Least squares 6.2.3 Maximumlikelihood estimation 6.3 ALGORITHMS FOR OPTIMISATION 6.3.1 Desiderata 6.3.2 Gradient-based methods 6.3.3 Direct search methods 6.3.4 Evolutionary algorithms 6.4 POST-REGRESSION DIAGNOSTICS 6.4.1 Model selection 6.4.2 Sensitivity and robustness of biological models 6.5 TROUBLESHOOTING 6.5.1 Regularisation 6.5.2 Sloppiness 6.5.3 Choosing a search algorithm 6.5.4 Model reduction 6.5.5 The curse of dimensionality 6.6 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Discrete dynamic models: Boolean networks 7.1 INTRODUCTION 7.2 BOOLEAN NETWORKS: TRANSFER FUNCTIONS 7.2.1 Characterising Boolean network dynamics 7.2.2 Synchronous vs. asynchronous updates 7.3 OTHER PARADIGMS 7.3.1 Probabilistic Boolean networks 7.3.2 Logical interaction hypergraphs 7.3.3 Generalised logical networks 7.3.4 Petri nets 7.4 APPLICATIONS 7.5 TROUBLESHOOTING 7.6 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Introduction to constraint-based modelling 8.1 WHAT ARE CONSTRAINTS? 8.1.1 Types of constraints 8.1.2 Mathematical representation of constraints 8.1.3 Why are constraints useful? 8.2 THE STOICHIOMETRICMATRIX 8.3 STEADY-STATEMASSBALANCE:FLUXBALANCEANALYSIS (FBA)8.4 THE OBJECTIVE FUNCTION 8.4.1 The biomass objective function 8.5 OPTIMISATION TO COMPUTE FLUX DISTRIBUTION 8.6 AN ILLUSTRATION 8.7 FLUX VARIABILITY ANALYSIS (FVA) 8.8 UNDERSTANDING FBA 8.8.1 Blocked reactions and dead-end metabolites 8.8.2 Gaps in metabolic networks 8.8.3 Multiple solutions8.8.4 Loops 8.8.5 Parsimonious FBA (pFBA) 8.8.6 ATP maintenance fluxes 8.9 TROUBLESHOOTING 8.9.1 Zero growth rate 8.9.2 Objective values vs. flux values 8.10 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Extending constraint-based approaches 9.1 MINIMISATION OF METABOLIC ADJUSTMENT (MOMA) 9.1.1 Fitting experimentally measured fluxes 9.2 REGULATORY ON-OFF MINIMISATION (ROOM) 9.2.1 ROOMvs.MoMA 9.3 BI-LEVEL OPTIMISATIONS 9.3.1 OptKnock9.4 INTEGRATING REGULATORY INFORMATION 9.4.1 Embedding regulatory logic: regulatory FBA (rFBA) 9.4.2 Informing metabolic models with omic data 9.4.3 Tissue-specific models 9.5 COMPARTMENTALISED MODELS 9.6 DYNAMIC FLUX BALANCE ANALYSIS (dFBA) 9.7 13C-MFA 9.8 ELEMENTARY FLUX MODES AND EXTREME PATHWAYS 9.8.1 Computing EFMs and EPs 9.8.2 Applications EXERCISES REFERENCES FURTHER READING Perturbations to metabolic networks10.1 KNOCK-OUTS 10.1.1 Gene deletions vs. reaction deletions 10.2 SYNTHETIC LETHALS 10.2.1 Exhaustive enumeration 10.2.2 Bi-level optimisation 10.2.3 Fast-SL: massively pruning the search space 10.3 OVER-EXPRESSION 10.3.1 Flux Scanning based on Enforced Objective Flux (FSEOF) 10.4 OTHER PERTURBATIONS 10.5 EVALUATING AND RANKING PERTURBATIONS 10.6 APPLICATIONS OF CONSTRAINT-BASED MODELS 10.6.1 Metabolic engineering 10.6.2 Drug target identification 10.7 LIMITATIONS OF CONSTRAINT-BASED APPROACHES 10.7.1 Scope of genome-scale metabolic models 10.7.2 Incorrect predictions 10.8 TROUBLESHOOTING10.8.1 Interpreting gene deletion simulations 10.9 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Modelling cellular interactions 11.1 MICROBIAL COMMUNITIES 11.1.1 Network-based approaches 11.1.2 Population-based and agent-based approaches 11.1.3 Constraint-based approaches 11.2 HOST–PATHOGEN INTERACTIONS (HPIs) 11.2.1 Network models 11.2.2 Dynamic models 11.2.3 Constraint-based models 11.3 SUMMARY11.4 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Designing biological circuits 12.1 WHAT IS SYNTHETIC BIOLOGY? 12.2 FROMLEGO BRICKS TO BIOBRICKS 12.3 CLASSIC CIRCUIT DESIGN EXPERIMENTS 12.3.1 Designing an oscillator: the repressilator 12.3.2 Toggle switch 12.4 DESIGNING MODULES 12.4.1 Exploring the design space 12.4.2 Systems-theoretic approaches 12.4.3 Automating circuit design 12.5 DESIGN PRINCIPLES OF BIOLOGICAL NETWORKS 12.5.1 Redundancy 12.5.2 Modularity 12.5.3 Exaptation 12.5.4 Robustness 12.6 COMPUTING WITH CELLS 12.6.1 Adleman’s classic experiment 12.6.2 Examples of circuits that can compute 12.6.3 DNA data storage 12.7 CHALLENGES 12.8 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Robustness and evolvability of biological systems 13.1 ROBUSTNESS IN BIOLOGICAL SYSTEMS 13.1.1 Key mechanisms 13.1.2 Hierarchies and protocols 13.1.3 Organising principles 13.2 GENOTYPE SPACES AND GENOTYPE NETWORKS 13.2.1 Genotype spaces 13.2.2 Genotype–phenotype mapping 13.3 QUANTIFYING ROBUSTNESS AND EVOLVABILITY 13.4 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Epilogue: The Road Ahead Index 325
£44.99
Taylor & Francis Ltd Understanding Risk to Wildlife from Exposures to
Book SynopsisUnderstanding Risk to Wildlife from Exposures to Per- and Polyfluorinated Alkyl Substances (PFAS) provides the most recent summary of toxicity data relevant to mammals, birds, reptiles, and amphibians, and provides values for use in risk assessment applications. Predicting the bioaccumulation of PFAS in terrestrial wildlife (including humans) has proven to be extremely complex. As a group, PFAS act differently than traditional non-ionic organic molecules, where PFAS can break down and reform, whereas some are demonstrated to be extremely persistent. Where sufficient data are provided, this book establishes toxicity reference values (TRVs), which are derived to assist in characterizing environmental sources of contamination and making risk-based decisions.Features: Provides toxicity reference values (TRVs) for vertebrates (mammals, birds, amphibians) for PFAS, where sufficient data are available, and includes objective supporting background informatTable of ContentsChapter 1 Introduction Chapter 2 Perfluorooctanoic acid (PFOA) Chapter 3 Perfluorooctane Sulfonate (PFOS) Chapter 4 Perfluorohexane Sulfonate (PFHxS) Chapter 5 Perfluororoheptanoic Acid (PFHpA) Chapter 6 Perfluorononanoic Acid (PFNA) Chapter 7 Perfluorobutane Sulfonate (PFBS) Chapter 8 6:2 Fluorotelomer Sulfonate (6:2 FTS) Chapter 9 Perfluorodecanoic Acid (PFDA) References Index
£104.50
Taylor & Francis Ltd Membrane and MembraneBased Processes for Wastewater Treatment
a huge range and FREE tracked UK delivery on ALL orders.
£109.25
Taylor & Francis Ltd Fermentation and Algal Biotechnologies for the Food Beverage and Other Bioproduct Industries
a huge range and FREE tracked UK delivery on ALL orders.
£114.00
Taylor & Francis Ltd Medical Biotechnology Biopharmaceutics Forensic Science and Bioinformatics
a huge range and FREE tracked UK delivery on ALL orders.
£137.75
Taylor & Francis Ltd Organic Chemistry
a huge range and FREE tracked UK delivery on ALL orders.
£128.25
Taylor & Francis Ltd Marine Microbial Bioremediation
a huge range and FREE tracked UK delivery on ALL orders.
£61.99
Taylor & Francis Forensic Toxicology
a huge range and FREE tracked UK delivery on ALL orders.
£105.00
Taylor & Francis Forensic Toxicology
a huge range and FREE tracked UK delivery on ALL orders.
£73.14
Taylor & Francis Ltd Biomembrane Simulations Computational Studies of Biological Membranes
a huge range and FREE tracked UK delivery on ALL orders.
£51.29
Taylor & Francis Ltd Ecotoxicology Perspectives on Key Issues
a huge range and FREE tracked UK delivery on ALL orders.
£43.69
Taylor & Francis Ltd Strategies for Bioremediation of Organic and Inorganic Pollutants
a huge range and FREE tracked UK delivery on ALL orders.
£43.69
Taylor & Francis Ltd Marine Pollution and Climate Change
a huge range and FREE tracked UK delivery on ALL orders.
£43.69
Taylor & Francis Ltd Molecular Analyses
a huge range and FREE tracked UK delivery on ALL orders.
£128.25
Taylor & Francis Ltd Toxicity and Risk Context Principles and Practice
Book SynopsisThis book aims to set out the political, social, legal and scientific underpinning of risk assessment and risk management for toxic substances. It describes the principles and processes the practitioners undertake when looking at the regulatory risk implications of their work.Table of ContentsPreface -- Acknowledgements -- 1 Introduction -- PART I -- The context in which toxic risk analysis takes place -- 2 What risk management covers -- 3 Legal and organisational frameworks -- 4 Philosophical frameworks for handling risk -- 5 The importance of risk perception and risk -- communication for toxicological risk assessment -- PART II -- The principles and practice of toxic risk analysis -- 6 Introduction: Royal Society and National Academy of Sciences -- 7 Toxicological assessment -- 8 Evaluation of human health effects: toxicity -- 9 Evaluation of human health effects: exposure -- 10 The special case of major accident hazards -- 11 Evaluation of effects on the environment -- 12 Effects on the atmosphere -- References -- Appendix -- Index.
£73.14
Taylor & Francis Ltd Pesticide Residues in Coastal Tropical Ecosystems
Book SynopsisThe coastal tropics comprise some of the most sensitive and yet the most understudied ecosystems in the world. Coastal plains and river valleys are also home to agriculture on a vast scale, and it is not surprising to find that streams and rivers receive the majority of agricultural runoff, carrying the residues of insecticides, fungicides and other pesticides into estuaries and coastal zones. There is a growing awareness of the urgent need to develop strategies to help productive, healthy and economically viable agriculture to coexist with natural resources. Pesticide Residues in Tropical Coastal Ecosystems brings together toxicology experts from around the world to assess pesticide burdens in many of the major food-producing tropical countries. It provides a unique set of case studies, chronicling pesticide usage and its ecotoxicological impact in coastal regions. A practical guide to recent research findings and applications, it is essential reading for environmental professionals, Table of ContentsIntroduction. Pesticides in the Marine Environment of Ghana. Pesticide Use in Zimbabwe: Impact on Lake Kariba, a Tropical Freshwater Ecosystem. Pesticides in Kenya. Distribution, Fate and Effects of Pesticides in the Tropical Coastal Zones of India K.. Pesticides in Bangladesh. Pesticide Use in Malaysia: Trends and Impacts. Distribution, Fate and Impact of Pesticides in the Tropical Marine Environment of Vietnam. Pesticides in the Peoples Republic of China. Ecotoxicology of Pesticides in the Philippines' Aquatic Ecosystem. Pesticides in the Coastal Zone of Mexico. The Use of Pesticide in Costa Rica and Their Impact on Coastal Ecosystems. Pesticides in Colombia: Their Application, Use and Legislation. Pesticide Use in Cuban Agriculture: Present and Prospects. Use, Fate and Ecotoxicity of Pesticides in Jamaica and the Commonwealth Caribbean. Coastal Watershed-Based Ecological Risk Assessment - Gulf of Mexico. Summary.
£209.00
Taylor & Francis Ltd Target Organ Toxicity in Marine and Freshwater Teleosts Organs New Perspectives Toxicology and the Environment
a huge range and FREE tracked UK delivery on ALL orders.
£175.75
Taylor & Francis Ltd Metabolic Regulation in Mammals
Book SynopsisMetabolic Regulation in Mammals presents the basic principles of metabolic control, based on investigations conducted during the past twenty years. It explains the impact of recent advances in cell biology, molecular biology and genetics on the field. Beginning with the basic concepts, this text covers all angles of metabolic regulation, including blood caloric homeostasis, cardiac and skeletal muscle, adipose tissue, and liver metabolism. Review questions, summary sections and worked examples help break down the complexity of the subject and allow the reader to review the principles and concepts presented. Details of metabolic pathways are provided for each body system, with accompanying charts to provide the reader with an overall perspective. This text is ideal for undergraduates across a range of biological and health science disciplines, particularly those taking one or two semester courses in metabolic regulation.Table of ContentsIntroduction: Metabolism. Enzyme-catalyzed Reactions. Overview of Signal Transduction. Glycolysis. Citric Acid Cycle. Fatty Acid Oxidation. Amino Acid Metabolism. Glycogen. Gluconcogenesis. Synthesis of Triglycerides. Cholesterol. Metabolic Interrelationships of Tissue.
£166.25
Taylor & Francis Ltd Investigative Immunotoxicology
a huge range and FREE tracked UK delivery on ALL orders.
£166.25
Taylor & Francis A Suitable Amount of Crime
a huge range and FREE tracked UK delivery on ALL orders.
£128.25
Taylor & Francis Disjunctivism
a huge range and FREE tracked UK delivery on ALL orders.
£128.25
Taylor & Francis New Horizons in Arts Heritage Nonprofit and Social Marketing
a huge range and FREE tracked UK delivery on ALL orders.
£82.64
Taylor & Francis Ltd Development of a LowCost Alternative for Metal Removal from Textile Wastewater UNESCOIHE PhD Thesis
a huge range and FREE tracked UK delivery on ALL orders.
£56.04
Taylor & Francis The Imperial Quest and Modern Memory from Conrad to Greene Literary Criticism and Cultural Theory
a huge range and FREE tracked UK delivery on ALL orders.
£45.59
Taylor & Francis Ltd The Imperial Quest and Modern Memory from Conrad to Greene Literary Criticism and Cultural Theory
a huge range and FREE tracked UK delivery on ALL orders.
£128.25
Taylor & Francis Ltd Paradiplomacy in Action
a huge range and FREE tracked UK delivery on ALL orders.
£142.50
Taylor & Francis Ltd Paradiplomacy in Action
a huge range and FREE tracked UK delivery on ALL orders.
£56.04
Taylor & Francis Ltd Trichoderma And Gliocladium Volume 2
a huge range and FREE tracked UK delivery on ALL orders.
£209.00
Taylor & Francis Ltd Guide to Cytochromes P450
a huge range and FREE tracked UK delivery on ALL orders.
£215.09
Taylor & Francis Ltd Protein Geometry Classification Topology and Symmetry A Computational Analysis of Structure Series in Biophysics
a huge range and FREE tracked UK delivery on ALL orders.
£166.25
CRC Press Principles and Practice of Bioanalysis
Book SynopsisIn the seven years since the publication of Principles and Practice of Bioanalysis bioanalytical methods have remained the same, but their usage patterns have changed. This second edition of a bestseller provides an updated guide to the techniques used in developing and running ultra-trace analyses for drugs, metabolites, and other substances.Extensively revised, this volume reflects the dynamic growth in methodologies that has occurred over the past five years. Each chapter has been overhauled or re-written to reflect modern practice. Experts in the field offer a logical path through the problems of small molecule bioanalysis, enabling you to choose the appropriate methods of analysis across a number of fields, including the agrochemical and pharmaceutical industries. They cover a wide range of analytical methods, including mass spectrometry, liquid chromatography, immunoassay, NMR, and gas chromatography. Presenting the information in an informal and highly acTrade Review"The book consists of 15 chapters written by internationally distinguished experts from biotech and pharmacological companies, mostly located in United Kingdom…. Each chapter contains a bibliography of the most important papers in each field discussed in the book. This book is quite valuable theoretically and methodologically for specialists of various fields of analytical chemistry and biochemistry, molecular biology, and biotechnology. I believe that this book will become an important desk book for researchers working with bioanalysis of various drugs and metabolites."—G. Ya. Wiederschain, Doctor of Biological Sciences, in Biochemistry, 2008, Vol. 73, No. 12"… a living guide on the subject, scrutinizing how its topics have changed over the years – mass spectronomy, immunoassay, gas chromatography and more. A scholarly, seminal piece, Principles and Practices of Bioanalysis is highly recommended for community library science collections." – James A. Cox and Diane C. Donovan in Midwest Book Review, 2008"I found it instructive and interesting – an adjective that unfortunately can only be applied to textbooks relatively infrequently!" – E. R. Adlard, in Chromatographia, July 2008, Vol. 68, No. 1/2Table of ContentsPhysico-chemical Properties of Drugs and Metabolites and their Extraction from Biological Material. Solid Phase Extraction. Basic HPLC Theory and Practice. HPLC Optimisation. HPLC Detectors. Gas Chromotography: What It Is and How We Use It. Thin Layer Chromotography. Capillary Electrophoresis. Immunoassay Techniques. Automation of Sample Preparation. Fundamental Aspects of Mass Spectrometry . Applications of Mass Spectrometry. Quantitative Mass Spectometry. Mass Spectrometric Identification of Metabolites. Nuclear Magnetic Resonance in Drug Metabolism. Strategy in Metabolite Isolation and Identificaiton. Strategy for the Development of Quantitative Analytical Procedures.
£109.25
Taylor & Francis Drug Testing Technology
a huge range and FREE tracked UK delivery on ALL orders.
£147.25
Taylor & Francis Ltd Parasitism and Host Behaviour
a huge range and FREE tracked UK delivery on ALL orders.
£285.00
Taylor & Francis Ltd The Toxic Microbiome
Book SynopsisGut microbiomes are dynamic communities varying from population to population and throughout life. In Western societies, a toxic metabolic shift of gut microbiomes is a driver and underestimated risk factor for the development of many noncommunicable chronic pathologies. This book identifies the root cause of these deleterious microbial changes. During the last several decades, increased consumption of animal products, coinciding and correlating with global climate change, has been a contributing cause of undesirable gut microbiome changes.Key Features Establishes a connection between poor gut microbiome health and chronic disease and cancer development Demonstrates how animal products and low-fiber diet patterns induce a detrimental metabolic transition of the gut microbiome from a human health-maintaining towards a disease-promoting state Discusses the opportunity of a toxic microbial metabolic signatTable of ContentsTable of Contents Dedication Preface Introduction Chapter 1: Diet related chronic diseases are the most critical health problem of modern societies – how did that happen? Chapter 2: The "industrialized" microbiome - a caution label for a global epidemic Missing microbes - does it matter? Chapter 3: The subtle problems of microbiome research Is the microbiome "oversold"? Is microbiome science heading in the wrong direction? Chapter 4: The gut microbiome: a new perspective Our microbiome is a metabolic organ Functional omes: metabolites over species Finding a new definition for a "healthy" microbiome and "dysbiosis" Chapter 5: Shaping the microbial behavior Diet: the master educator of the gut microbiome Starving the microbial self: a foundation for developing a chronic disease Chapter 6: The toxic microbiome "It’s not the fiber, it’s the animal protein" Protein fermentation Fat toxicity Secondary bile acids Heme iron TMAO: the way to a man’s heart is through his gut microbiota Toxicomicrobiomics A toxic microbiome: useful for predicting chronic diseases? Chapter 7: How to build a healthy gut microbiome and prevent chronic diseases The "true" human diet: are humans really omnivores? "The Paleo diet is a myth" Protein concerns: Do we get enough on plants? Feeding microbes for disease prevention and treatment Chapter 8: "Fixing" the microbiome - Can we restore a healthy microbiome by other means than diet? Probiotics – hype or hope? Fecal microbial transplantation or "The Power of Poop" The "Wild West" of microbiome science: drugging the microbiome and personalized nutrition Glossary Abbreviations Literature
£39.99
Taylor & Francis Ltd A History of Radioecology
Book SynopsisThis book presents a history of radioecology, from World War II through to the critical years of the Cold War, finishing with a discussion of recent developments and future implications for the field. Drawing on a vast array of primary sources, the book reviews, synthesizes and discusses the implications of the ecological research supported by the Atomic Energy Commission (AEC) of the United States government, from World War II to the early 1970s. This was a critical period in the history of ecology, characterized by a transition from the older, largely descriptive studies of communities of plants and animals to the modern form of the science involving functional studies of energy flow and mineral cycling in ecosystems. This transition was in large part due to the development of radioecology, which was a by-product of the Cold War and the need to understand and predict the consequences of a nuclear war that was planned but has never occurred. The book draws on important case Table of ContentsPART 1 1. Introduction 2. Early Studies in Radioecology PART 2 3. The Pacific Proving Grounds 4. The Nevada Test Site 5. Alaska Coast 6. The Oak Ridge National Laboratory 7. El Verde, Puerto Rico 8. The Brookhaven National Laboratory 9. The Savannah River Ecology Laboratory PART 3 10. Radioecology Since the Cold War 11. Summary and Conclusions
£34.19
Taylor & Francis Ltd Learning from the COVID19 Pandemic
Book SynopsisCOVID-19 is a highly contagious viral illness caused by severe acute respiratory syndrome SARSCoV-2. It has had a devastating effect on the world's demographics with high morbidity and mortality worldwide. After the influenza pandemic of 1918, it has emerged as the most consequential global health crisis. After the first cases of this predominantly respiratory viral illness were first reported in Wuhan, Hubei Province, China, in late December 2019, SARS-CoV- 2 rapidly disseminated across the world in a short span of time, compelling the World Health Organization (WHO) to declare it a global pandemic on March 11, 2020. The outbreak of COVID-19 has proven to be a worldwide unprecedented disaster. It has physically, psychologically, socially, and economically afflicted billions of people across the globe. Its transmission is significantly high. Serious postrecovery has been noticed in a large number of people. The virus is highly mutable and new and new strains are appearing, and many Table of ContentsPreface. Author Biography. 1. Teaching, Learning And Caring In Post-covid Era2. Adoption Of Blended Learning Model In Higher Education Post Covid-193. Ode: Cruising Onto A New Education System4. Covid-19 Pandemic And Paradigms Of Education In Indian Heis: A Mapping Of Tectonic Shifts5. Paradigm Shift In Education And Career Choice Of Students In The New Normalpost Covid -19 Era6. An Impact Assessment Of Covid-19 Pandemic On The Higher Education Institutions Of India7. Academic Administration: Post Pandemic Challenges In Science Education8. Family Life And Education Under The Dark Shadow Of Covid-19 Pandemic In India: Some Observations9. Impact Of Covid -19 Pandemic On Education In Indian Context: Reimagining Education Beyond The Pandemic10. Telecommunication Interventions And Opportunities In Education, Health And Agriculture: Post Covid-19 Scenario 11. Technological Innovations And Challenges In Higher Education During Covid-19 Pandemic 12. Shift In Technology: A Mechanical Engineer’s Perspective In The Post Covid-19 World 13. Architecture Of Covid Era14. Maps, Digitalization And Citizenry (With Special Reference To Covid-19) 15. Covid-19 Pandemic And Environmental Sustainability16. Covid-19 Pandemic And Environmental Pollution: Opportunity To Revisit Environmental Strategies For Public Health Benefits17. Bio-medical Waste Management In Post Covid-19 Pandemic: Need For An Effective Regulation In India 18. Covid - 19 Pandemic : Social Response Through Changing Lifestyles 19. Emerging Life Styles In Urban India Under The Regime Of Covid-19 Pandemic: An Overview Of The Implications 20. Confronting Potential Role Of Yoga In Combatting Covid-19 Pandemic21. Lifestyle Communication, Environment And Development Sustainability: An Analytical Study From Consumption To Information Dissemination During Covid 19 22. Adoption Of Diet Pattern During Covid Pandemic 23. Life Post Covid-19 Pandemic: Opportunities And Challenges For The Decision Makers 24. Post Covid-19 Paradigm Shift: A New Era Of Digital Experience 25. Covid-19: Our Solutions Are In Nature
£45.99
Taylor & Francis Ltd Novel Plant Protein Processing
Book SynopsisProteins serve as an important nutritional as well as structural component of foods. Not only do they provide an array of amino acids necessary for maintaining human health but also act as thickening, stabilizing, emulsifying, foaming, gelling, and binding agents. The ability of a protein to possess and demonstrate such unique functional properties depends largely on its inherent structure, configuration, and how they interact with other food constituents, like, polysaccharides, lipids, and polyphenolic compounds. Proteins from animal sources have superior functionality, higher digestibility, and lower anti-nutrient components than plant proteins. However, consumer preferences are evolving worldwide for ethically and sustainably sourced, clean, cruelty-free, vegan or vegetarian plant-based food products. Unlike proteins from animal sources, plant proteins are more versatile, religiously, and culturally acceptable among vegetarian and vegan consumers and associated with lower food prTable of ContentsPreface. About the Editors. List of Contributors. Introduction to Plant Protein-Based Future Foods. Challenges in Designing of Plant Protein-Based Future Foods. Modification Methods of Plant-Based Proteins: An Overview. Biological Modification of Plant-Based Proteins. Thermal Modification of Plant-Based Proteins. Ultrasonication-Assisted Modification of Plant-Based Proteins. High-Pressure Processing of Plant-Based Proteins. Pulsed Electric Field Modifications of Plant-Based Proteins. Cold Atmospheric Plasma Processing of Plant-Based Proteins. Chemical Modification of Plant Proteins. Processing Techniques for Scaling Up of Modified Plant Proteins. Applications of Modified Plant Protein-Based Future Foods. Packaging: A Legal Aspect of Plant-Based Protein. Plant Protein-Based Foods, Trend from a Business Perspective: Market, Consumers’ Challenges, and Opportunities in Future. Index.
£166.25
Taylor & Francis Ltd Kinanthropometry and Exercise Physiology
Book SynopsisFully updated, revised and consolidated into one single volume, the fourth edition of Kinanthropometry and Exercise Physiology offers the best theoretically contextualised, practical resource for instructors and students available.Incorporating substantial sections on kinanthropometry, exercise physiology, energy systems and the application of science in health and high performance settings, the book covers the basics of measurement in exercise science through to advanced methods, and includes brand new chapters on: Pre-exercise screening and health risk stratification Functional movement assessment Point of care testing Anthropometry standards Anaerobic power and capacity History of exercise for health benefits Monitoring training loads in high-performance athletes Measuring game style in team sports Offering on-line access to newly developed exercise Table of ContentsSection I: Measurement in Exercise Science 1. Pre-exercise Screening and Health Risk AssessmentLynda H. Norton and Kevin I. Norton2. Movement Capacity Screening and AssessmentMax Martin, Hunter Bennett, Kade Davison, and John Arnold3. Blood Sampling and Point-Of-Care TestingLynda H. Norton and Kevin I. Norton 4. Standards for Anthropometry AssessmentKevin I. Norton5. Human Body CompositionJonathan Buckley, Michael Hawes, Alan Martin, and Roger G. Eston6. Anthropometry and Body Image Tim S. Olds7. Growth, Maturation, and Physical Fitness Alan R. Barker, Luis Gracia-Marco, Dimitris Vlachopoulos, and Craig A. Williams8. Scaling: Adjusting for Differences in Body SizeEdward M. Winter and Alan M. NevillSection II: Physiological Systems at Rest and During Exercise9. Lung FunctionAlan J. Crockett, Tjard R. Schermer, and Roger G. Eston10. Assessment of Neuromuscular Performance Using ElectromyographyNigel Gleeson11. ThermoregulationN. Tim Cable and Sam Chalmers12. Anaerobic Lactacid Energy System: Measures of Anaerobic Lactacid Power and CapacityDavid Bishop and Nicholas Jamnick13. Aerobic Exercise PerformanceAndrew M. Jones, Mark Burnley, and Anni Vanhatalo14. Maximal Oxygen Uptake, Economy, and EfficiencyCarlton B. Cooke and Mark J. Cooke15. Metabolic Rate and Energy Balance Carlton B. Cooke and Mark J. Cooke Section III: Applications for Health and Performance16. The Exercise-health Paradigm: A Historical PerspectiveKatherine Devonshire-Gill17. Characterising Physical Behaviours in Free-Living Populations: How Much? When? Where? What?Alex V. Rowlands18. Perceived Exertion, Heart Rate and Other Non-Invasive Methods for Exercise Testing And Intensity ControlRoger G. Eston and Gaynor Parfitt 19. Physiological Basis for Training and Monitoring the Training Response Stuart R. Graham and Grace Greenham20. Game Style in Team Sports: What Is It and How to Measure It? Stuart Gollan, Adam Hewitt, Grace Greenham, and Kevin I. Norton21. Anaerobic Power and Capacity in Masters AthletesPeter Reaburn, Thomas Doering, and Damon Arezzolo
£166.25
Taylor & Francis Ltd Glycome Informatics
Book SynopsisA Focused, State-of-the-Art Overview of This Evolving FieldPresents Various Techniques for GlycoinformaticsThe development and use of informatics tools and databases for glycobiology and glycomics research have increased considerably in recent years. In addition to accumulating well-structured glyco-related data, researchers have now developed semi-automated methods for the annotation of mass spectral data and algorithms for capturing patterns in glycan structure data. These techniques have enabled researchers to gain a better understanding of how these complex structures affect protein function and other biological processes, including cancer.One of the few up-to-date books available in this important area, Glycome Informatics: Methods and Applications covers all known informatics methods pertaining to the study of glycans. It discusses the current status of carbohydrate databases, the latest anTable of ContentsIntroduction to Glycobiology. Background. Databases. Glycome Informatics. Potential Research Projects. Appendices.
£99.75
Taylor & Francis Inc Practical Toxicology
Book SynopsisPractical Toxicology: Evaluation, Prediction, and Risk, Third Edition shows how to conduct a program of safety evaluation and testing and then to interpret and apply the resulting data and information in the real world, beginning with the basic concepts in toxicology and progressing to the interpretation of the resulting data. Revised and updated chapters on risk assessment guide the reader to setting the foundations necessary for submission to regulatory authorities. In addition, a new chapter in the book reviews the errors in toxicology, mistakes, misuse, mismanagement, and misunderstanding with a view to avoiding these in the future.New Chapters in the Third Edition: Toxicology in silico Errors in Toxicology Safety Assessment of Extractables and Leachables. This new edition follows a practical sequence from introducing the basics of toxicology (including the vital concept of normalityTable of ContentsIntroduction to Toxicology: The Necessity of Measurement. Normality: Definition and Maintenance. Determination of Toxicity: The Basic Principles. Determination of Toxicity: In Vitro and In Silico. Safety Pharmacology. Determination: General and Reproductive Toxicology. Distinguishing a Toxicological Effect from an Expected Pharmacological One. Determination: Genotoxicity and Carcinogenicity. Determination: Dermal Toxicity—Sensitization, Irritation, and Corrosion. Determination of Immunotoxicity: Biologics and Beyond. Determination of Nanotoxicity. Determination: Environmental Toxicology and Ecotoxicology. Interpretation: Basic Principles. Interpretation: Different Data Types. Prediction of Hazard. Background to Risk Due to Toxicity. Risk Assessment in Practice and Setting Exposure Limits. Risk Assessment for Extractables, Leachables, and Impurities. Risk Assessment and Management in the Workplace. Risk Assessment: Carcinogenicity; The Environment, Evolution, and Overview of Risk Assessment. Evaluation of Specific Classes of Chemical. Errors in Toxicology: An Introduction to the 4Ms. The Future of Toxicity Testing and Risk Assessment.
£73.14
Pan Stanford Publishing Pte Ltd Understanding Enzymes: Function, Design, Engineering, and Analysis
Book SynopsisUnderstanding Enzymes: Function, Design, Engineering, and Analysis focuses on the understanding of enzyme function and optimization gained in the past decade, past enzyme function analysis, enzyme engineering, and growing insights from the simulation work and nanotechnology measurement of enzymes in action in vitro or in silico. The book also presents new insights into the mechanistic function and understanding of enzyme reactions, as well as touching upon structural characteristics, including X-ray and nuclear magnetic resonance (NMR) structural methods. A major focus of the book is enzyme molecules’ dependency on dynamic and biophysical environmental impacts on their function in ensembles as well as single molecules. A wide range of readers, including academics, professionals, PhD and master’s students, industry experts, and chemists, will immensely benefit from this exclusive book.Table of ContentsA practical guide to the quantitative analysis of engineered enzymes. Protein Conformational Motions - Enzyme Catalysis. Enzymology meets Nanotechnology: Single-molecule methods for observing enzyme kinetics in real time. Interfacial enzyme function visualized using neutron, x-ray and light scattering methods. Folding dynamics and structural basis of the enzyme mechanism of ubiquitin C-terminal hydroylases. Stabilisation of Enzymes by metal binding: Structures of Alkalophilic Bacillus proteinases and analysis of the second metal binding site of subtilases. Structure and Functional Roles of Surface Binding Sites in Amylolytic Enzymes. Interfacial Enzymes and their Interactions with Surfaces: Molecular Simulation Studies. Sequence, structure, function: What we learn from analyzing protein families. Bioinformatic analysis of protein families to select function-related variable positions. Decoding life secrets in sequences by chemicals. Role of tunnels and gates in enzymatic catalysis. Molecule descriptors for the structureal analysis of enzyme active sites. Hydration effects on enzyme properties in nonaqueous media analysed by MD simulations. Understanding esterase and amidase reaction specificities by molecular modelling. Towards new non-natural TIM-barrel enzymes using computational design and directed evolution approaches. Handling the Numbers Problem in Directed Evolution. Hints from Nature: Metagenomics in Enzyme Engineering. A functional and structural assessment of circularly permuted Bacillus circulans xylanase and Candida antarctica lipase B. Ancestral Reconstruction in Enzymes. High throughput screening or selection methods for evolutionary enzyme engineering. Nanoscale Enzyme Screening Technologies. Computational Enzyme Engineering: Activity Screening using Quantum Chemistry. In silico screening of enzyme variants by molecular dynamics simulation. Kinetic and thermodynamic stability of variant enzymes.
£171.00
Cambridge University Press Biochemistry and Physiology of the Neutrophil
a huge range and FREE tracked UK delivery on ALL orders.
£64.59