Biochemistry Books

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Book SynopsisRebeca Skloot is the author of The Immortal Life of Henrietta Lacks and an award-winning science writer whose articles have appeared in the New York Times Magazine and O, the Oprah Magazine, among others. She has worked as a correspondent for NPR's RadioLab and PBS's Nova ScienceNOW, and blogs about science, life, and writing at Culture Dish, hosted by Seed magazine. She also teaches creative nonfiction at the University of Memphis.

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Book SynopsisSelected as a Doody's Core Title for three years running!   A bestselling title in this highly regarded review series, Lippincott® Illustrated Reviews: Biochemistry is the go-to resource for both faculty and students for mastering the essentials of biochemistry. The fully revised 9th Edition helps students quickly review, assimilate, and integrate large amounts of critical and complex information, with unparalleled illustrations that bring concepts to life. An intuitive outline organization, chapter summaries, and review questions that link basic science to real-life clinical situations work together to clarify challenging information and strengthen retention and understanding, while an emphasis on clinical application, updated review tools, and accompanying digital resources prepare students for success on course and board exams and beyond. Every aspect of Lippincott® Illustrated Reviews: Biochemistry, 9th Edition, has been brought fully up to date, including: Student-friendly features such as chapter overviews, summaries, board-style questions and answers, Clinical Application boxes, case studies with questions and answers, online animations, and more. Vibrant illustrations and detailed tables that clarify complex biochemical concepts. Study questions and answers for each chapter that test students’ retention and strengthen their test-taking confidence. Integrative case studies with review questions familiarize students with commonly encountered clinical scenarios and alert them to potential widespread implications of presenting issues. Cross-references to other Lippincott® Illustrated Reviews titles that help students grasp how biochemical concepts relate to other basic sciences.

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Book Synopsis'Indecently entertaining.' A Daily Mail Book of the WeekAn Amazon US Best Book of 2022''A fascinating tale of poisons and poisonous deeds which both educates and entertains.'' Kathy ReichsAs any reader of murder mysteries can tell you, poison is one of the most enduring and popular weapons of choice for a scheming murderer. It can be slipped into a drink, smeared onto the tip of an arrow or the handle of a door, even filtered through the air we breathe. But how exactly do these poisons work to break our bodies down, and what can we learn from the damage they inflict?In a fascinating blend of popular science, medical history, and narrative crime nonfiction, Dr Neil Bradbury explores this most morbidly captivating method of murder from a cellular level. Alongside real-life accounts of murderers and their crimes some notorious, some forgotten, some still unsolved are the equally compelling stories of the poisons involved: eleven molecules of death that work their way through the humanTrade Review‘This very splendid book is essentially a detailed primer on how to dispose of your enemies. … A winning mixture of hard science and true crime stories, is almost indecently entertaining.’ Daily Mail ‘Lively … Bradbury is an engaging, cheerful tour guide.’ New York Times Book Review ‘Captivating in its storytelling and just enough science for the geeks. A tremendously entertaining dip into the dark and compelling world of death.’ Professor Dame Sue Black, author of All That Remains: A Life in Death ‘We’ve all seen Colonel Mustard dead in the library from poisoning. Instead of telling us why, in this original and invigorating book, Neil Bradbury focuses on how, exploring the workings of crime from a scientific basis. Fascinating.’ Judith Flanders, author of The Invention of Murder 'Neil Bradbury writes with wit, flair, and authority.' Lindsey Fitzharris, bestselling author of The Butchering Art ‘An engrossing history of poisons, poisonings and poisoners. Alongside the very human stories of the people who fall victim to these deadly substances, it’s packed with quirky detail and easily digestible (pun intended) science.’ Kate Morgan, author of Murder: The Biography 'Weaves jaw-dropping true stories and spellbinding histories behind the most infamous poisons.' Lydia Kang, bestselling author of Quackery: A Brief History of the Worst Ways to Cure Everything 'An unselfconsciously jaunty work of horror. Its stories may leave you eyeing your housemates and sniffing your coffee.' Judy Melinek, M.D. and T.J. Mitchell, bestselling authors of Working Stiff ‘An accessible and fascinating study.’ Publishers Weekly starred review ‘Appealing to any true crime fan … genre-bending.’ Booklist ‘A frightening romp … fascinating, edifying, and terrifying.’ Library Journal

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Book SynopsisBioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry is the first student textbook on the separation science and mass spectrometry of pharmaceuticals present in biological fluids with an educational presentation of the principles, concepts and applications. It discusses the chemical structures and properties of low- and high-molecular drug substances; the different types of biological samples and fluids that are used; how to prepare the samples by extraction, and how to perform the appropriate analytical measurements by chromatographic and mass spectrometric methods. Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry: Is an introductory student textbook discussing the different principles and concepts clearly and comprehensively, with many relevant and educational examples Focuses on substances that are administered as human drugs, including low-moleculaTable of ContentsContributing Authors ix Preface xi 1. Introduction 1Stig Pedersen-Bjergaard 1.1 What Is Bioanalysis? 1 1.2 What Is the Purpose of Bioanalysis, and Where Is It Conducted? 2 1.3 Bioanalysis Is Challenging 6 1.4 The Different Sections of This Textbook 7 2. Physicochemical Properties of Drug Substances 9Steen Honoré Hansen and Leon Reubsaet 2.1 Bioanalysis in General 9 2.2 Protolytic Properties of Analytes 10 2.3 Partitioning of Substances 12 2.4 Stereochemistry 15 2.5 Peptides and Proteins 18 3. Biological Samples: Their Composition and Properties, and Their Collection and Storage 23Steen Honoré Hansen 3.1 Introduction 23 3.2 Blood, or Whole Blood 24 3.3 Plasma and Serum 26 3.4 Urine 26 3.5 Feces 27 3.6 Saliva 28 3.7 Cerebrospinal Fluid 28 3.8 Synovial Fluid 28 3.9 Hair and Nails 29 3.10 Tissue (Biopsies) 29 4. General Chromatographic Theory and Principles 31Steen Honoré Hansen 4.1 General Introduction 31 4.2 General Chromatographic Theory 32 4.3 Theory of Partition 33 4.4 Retention 34 4.5 Separation Efficiency 35 4.6 Resolution 36 4.7 Selectivity 37 4.8 The Separation Process 38 4.9 Chromatographic Principles 41 4.10 Reversed Phase Chromatography 45 4.11 Size Exclusion Chromatography (SEC) 54 4.12 Ion Exchange Chromatography 56 4.13 Chiral Separations 57 5. Quantitative and Qualitative Chromatographic Analysis 61Steen Honoré Hansen 5.1 Collection of Chromatographic Data 61 5.2 Quantitative Measurements 62 5.3 Calibration Methods 63 5.4 Validation 67 5.5 Qualitative Analysis 69 6. Sample Preparation 73Stig Pedersen-Bjergaard, Astrid Gjelstad, and Trine Grønhaug Halvorsen 6.1 Why Is Sample Preparation Required? 73 6.2 What Are the Main Strategies? 75 6.3 Protein Precipitation 75 6.4 Liquid–Liquid Extraction 80 6.5 Solid-Phase Extraction 94 6.6 Dilute and Shoot 110 6.7 What Are the Alternative Strategies? 113 7. High-Performance Liquid Chromatography (HPLC) and High-Performance Liquid Chromatography–Mass Spectrometry (LC-MS) 123Steen Honoré Hansen and Leon Reubsaet 7.1 Introduction 123 7.2 The Solvent Delivery System 125 7.3 Degassing and Filtering of Mobile Phases 127 7.4 Injection of Samples 128 7.5 Temperature Control 128 7.6 Mobile Phases 129 7.7 Stationary Phases and Columns 130 7.8 Detectors 135 7.9 Mass Spectrometric Detection 143 8. Gas Chromatography (GC) 173Stig Pedersen-Bjergaard 8.1 Basic Principles of GC 173 8.2 GC Instrumentation 174 8.3 Carrier Gas 177 8.4 Stationary Phases 178 8.5 Separation Selectivity in GC 180 8.6 Columns 182 8.7 Injection Systems 183 8.8 Detectors 185 8.9 Derivatization 187 8.10 Gas Chromatography–Mass Spectrometry (GC-MS) 188 9. Analysis of Small-Molecule Drugs in Biological Fluids 207Steen Honoré Hansen and Stig Pedersen-Bjergaard 9.1 Plasma and Serum Samples 207 9.2 Whole Blood Samples 234 9.3 Dried Blood Spots 241 9.4 Urine Samples 245 9.5 Saliva 253 References 259 10. Analysis of Peptide and Protein Drugs in Biological Fluids 261Leon Reubsaet and Trine Grønhaug Halvorsen References 282 11. Regulated Bioanalysis and Guidelines 283Martin Jørgensen and Morten A. Kall 11.1 Introduction 283 11.2 The Evolution of Regulated Bioanalysis 284 11.3 Bioanalytical Method Validation 286 11.4 Pre-study Validation 287 11.5 In-Study Validation 299 11.6 Documentation 300 11.7 Regulatory Requirements to Bioanalysis 300 11.8 Quality Systems in Regulated Bioanalysis 301 Index 305

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Book SynopsisUp to date, easy to use, and rich with vibrant illustrations, Lippincott® Illustrated Reviews: Cell and Molecular Biology, 3rd Edition, provides a highly visual presentation of essential cell and molecular biology with a focus on topics related to human health and disease. This engaging approach incorporates all of the most popular features of the bestselling Lippincott® Illustrated Reviews series, including abundant full-color illustrations, chapter summaries, and review questions that link basic science to real-life clinical situations. The updated, versatile 3rd Edition can be used for a standalone cell biology course in medical, health professions, or other graduate and upper-level undergraduate programs; as a review for course and board exams; or in conjunction with other Lippincott® Illustrated Reviews for a seamless integrated course. UPDATED! Revised content throughout—including updated unit overviews and chapter summaries—helps students master the latest cell and molecular biology knowledge. UPDATED! Clinical Application boxes reinforce key concepts and enrich students’ understanding and clinical application capability. More than 250 full-color, annotated illustrations clarify complex processes and simplify study. Online animations and interactive review questions strengthen comprehension and retention.

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Book SynopsisElogiado por profesores y estudiantes durante más de dos décadas, Lippincott Illustrated Reviews. Bioquímica es uno de los mejores y más amigables textos de bioquímica para estudiantes de ciencias de la salud. Su contenido ayuda a los estudiantes a revisar, asimilar e integrar con rapidez grandes cantidades de información crítica y compleja, con el apoyo de ilustraciones que dan claridad a los conceptos.Table of ContentsUNIDAD I: Agua y estructura, y función de las proteínas Capítulo 1: Agua y pH Capítulo 2: Aminoácidos y la función del pH Capítulo 3: Estructura de las proteínas Capítulo 4: Proteínas globulares Capítulo 5: Proteínas fibrosas Capítulo 6: Enzimas UNIDAD II: Bioenergética y metabolismo de los carbohidratos Capítulo 7: Bioenergética y fosforilación oxidativa Capítulo 8: Introducción a los carbohidratos Capítulo 9: Introducción al metabolismo y la glucólisis Capítulo 10: Ciclo de los ácidos tricarboxílicos y el complejo piruvato deshidrogenasa Capítulo 11: Gluconeogénesis Capítulo 12: Metabolismo del glucógeno Capítulo 13: Metabolismo de monosacáridos y disacáridos Capítulo 14: La vía de la pentosa fosfato y del dinucleótido fosfato de nicotinamida y adenina Capítulo 15: Glucosaminoglucanos, proteoglucanos y glucoproteínas UNIDAD III: Metabolismo de los lípidos Capítulo 16: Metabolismo de los lípidos de la dieta Capítulo 17: Metabolismo de ácidos grasos, triacilglicerol y cuerpos cetónicos Capítulo 18: Metabolismo de fosfolípidos, glucoesfingolípidos y eicosanoides Capítulo 19: Metabolismo de colesterol, lipoproteínas y esteroides UNIDAD IV: Metabolismo del nitrógeno Capítulo 20: Aminoácidos: eliminación del nitrógeno Capítulo 21: Aminoácidos: degradación y síntesis Capítulo 22: Aminoácidos: conversión en productos especializados Capítulo 23: Metabolismo de nucleótidos UNIDAD V: Integración del metabolismo Capítulo 24: Efectos metabólicos de la insulina y el glucagón Capítulo 25: El ciclo alimentación-ayuno Capítulo 26: Diabetes mellitus Capítulo 27: Obesidad UNIDAD VI: Nutrición médica Capítulo 28: Nutrición: visión de conjunto y macronutrientes Capítulo 29: Micronutrientes: vitaminas Capítulo 30: Micronutrientes: minerales UNIDAD VII: Almacenamiento y expresión de la información genética Capítulo 31: Estructura, replicación y reparación del ADN Capítulo 32: Estructura, síntesis y procesamiento del ARN Capítulo 33: Síntesis de proteínas Capítulo 34: Regulación de la expresión génica Capítulo 35: Tecnologías del ADN y diagnóstico molecular de enfermedades humanas Capítulo 36: Coagulación de la sangre

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Book SynopsisSeventy years ago, Erwin Schrödinger posed a profound question: ''What is life, and how did it emerge from non-life?'' This problem has puzzled biologists and physical scientists ever since. Living things are hugely complex and have unique properties, such as self-maintenance and apparently purposeful behaviour which we do not see in inert matter. So how does chemistry give rise to biology? What could have led the first replicating molecules up such a path? Now, developments in the emerging field of ''systems chemistry'' are unlocking the problem. Addy Pross shows how the different kind of stability that operates among replicating molecules results in a tendency for chemical systems to become more complex and acquire the properties of life. Strikingly, he demonstrates that Darwinian evolution is the biological expression of a deeper, well-defined chemical concept: the whole story from replicating molecules to complex life is one continuous process governed by an underlying physical principle. The gulf between biology and the physical sciences is finally becoming bridged.This new edition includes an Epilogue describing developments in the concepts of fundamental forms of stability discussed in the book, and their profound implications.Oxford Landmark Science books are ''must-read'' classics of modern science writing which have crystallized big ideas, and shaped the way we think.Trade ReviewIn this inspiring book, Pross provides an engaging account of the view that systems chemistry can bridge the hitherto unassailable abiogenic/biogenic divide. In a carefully constructed, almost forensic, analysis, he confronts crucial issues, such as the conceptual gulf between the biochemist's chicken and egg problem...and the fundamental role of dynamic kinetic stability in the process of life. * Ben Mepham, The Biologist *Table of ContentsPrologue 1: Living things are so very strange 2: Historic quest for a theory of life 3: Understanding 'understanding' 4: Stability and instability 5: The knotty origin of life problem 6: Biology's crisis of identity 7: Biology is chemistry 8: What is Life? References and Notes Index

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Book SynopsisOrganic chemistry plays a vital role in the pharmaceutical industry. Knowledge of organic compounds is used to inform research and further the discovery and development of new medicines. Likewise, organic chemistry is fundamental to understanding biological reactions, mechanisms and all life sciences in general. Basic Chemistry for Life Science Students and Professionals is an ideal introduction to organic chemistry in the context of the life sciences and pharmacy related disciplines; utilising drug molecules to illustrate the chemical basis of their efficacy and interaction with biological targets. This book builds upon the basic concepts of organic chemistry to develop the reader’s understanding of the importance of organic chemistry to the life sciences from natural product sources, their synthesis, and approaches to drug discovery. Ideal for undergraduate students in the natural sciences, this book is also an excellent primer for postgraduates in a variety of disciplines including forensic science and allied-health programmes as well as professionals working in related fields seeking a comprehensive introduction to organic chemistry in the context of pharmaceuticals.Table of ContentsIntroduction to Organic Compounds and Covalent Bonding; Polarity of Bonds, Electronegativity, and Intermolecular Forces; Types of Organic Compounds, Nomenclature, and Basic Reactions: Alkanes and Cycloalkanes; Types of Organic Compounds, Nomenclature, and Basic Reactions: Alkenes, Cycloalkenes and Other Unsaturated Hydrocarbons; 5 Types of Organic Compounds, Nomenclature, and Basic Reactions: Functional Groups; Isomerism in Organic Compounds and Drug Molecules: Chemistry and Significance in Biology; Organic Macromolecules in Cellular Structures, Metabolism, and as Drugs: From Amino Acids to Proteins; Organic Macromolecules in Cellular Structures, Metabolism, and as Drugs: From Monosaccharides to Complex Carbohydrates; Organic Macromolecules in Cellular Structures, Metabolism, and as Drugs: From Fatty Acids to Complex Lipids and Fat; Organic Macromolecules in Cellular Structures, Metabolism, and as Drugs: From Nucleotides to Nucleic Acids; Physicochemical Properties of Organic Compounds and Drug Molecules; Drug-Target Interactions; Structural Diversity and Sources of Drugs: From Nature to Synthetic and Recombinant DNA Technology

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Table of ContentsPART I: Biologic and Molecular Basis for Regenerative Medicine PART II: Cells and Tissue Development PART III: Biomaterials for Regenerative Medicine PART IV: Therapeutic Applications Section A: Cell Therapy Section B: Tissue Therapy PART V: Regulation and Ethics

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Book SynopsisTerpenoids are the secondary metabolites of plant derivatives, mainly found in essential oils derived from higher plant sources. Terpenes are simple hydrocarbons, whereas terpenoids are modified terpenes containing different functional groups and oxidised methyl groups. This volume includes seven chapters examining topics related to terpenes and terpenoids. Chapter One describes mono- and sesquiterpenoids isolated from plants of the Inula L. genus and discusses biological activity of extracts and individual sesquiterpene lactones. Chapter Two covers the nature of terpenoids together with their biological activities and their isolation from endemic species from the Asteraceae family growing in Algerian Sahara and used as medicinal plants. Chapter Three introduces a catalyst system using Keggin heteropolyacid salts and hydrogen peroxide to epoxidise terpenic alcohols. Chapter Four examines the phyto-active components of terpenoids as sources of insecticide. Chapter Five describes how organic compounds containing functional groups like ketone, alcohol, and epoxide undergo rearrangement with sulfuric acid, yielding unexpected results. Chapter Six focuses on alkoxylation of terpenes over heterogenous catalysts. Lastly, Chapter Seven presents a discussion about the importance of Brazilian flora for herbal medicine.Table of ContentsPreface; Terpenoids of Inula L.Genus Plants; Phytochemical Prospection of Biologically Active Terpenoids from Saharan Endemic Medicinal Plants; Keggin Heteropolyacid Salts-Catalyzed Terpenes Epoxide Synthesis; Terpenoids: The Phyto-Active Components as Sources of Insecticide; Sulfuric Acid Promoted Molecular Rearrangement: Applications in Synthesis of Terpenoid Compounds; Alkoxylation of Terpenes over Heterogenous Catalysts; Characteristics and Applications of Terpenes and Terpenoids from Brazilian Flora; Index.

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Book SynopsisBiotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs, Second Edition addresses the pivotal issues relating to translational science, including preclinical and clinical drug development, regulatory science, pharmaco-economics and cost-effectiveness considerations. The new edition also provides an update on new proteins and genetic medicines, the translational and integrated sciences that continue to fuel the innovations in medicine, as well as the new areas of therapeutic development including cancer vaccines, stem cell therapeutics, and cell-based therapies.Trade Review“Overall, this book provides a valuable resource that can be utilized as a quick look-up guide and, more importantly, as an educational tool that can be used in strategic planning. The presentation style provides comprehensive information amenable to a diverse audience.” (Clinical Infectious Diseases, 30 October 2014)Table of ContentsContributors xiii Foreword xv Preface xvii Preface to the First Edition xix Acknowledgments xxi Organization of the Book xxiii User Agreement xxv Part I Transforming Proteins and Genes into Drugs—The Science and the Art 1 1 Introduction to Biopharmaceuticals 3 Abstract 3 1.1 Background and Significance 4 1.2 Translation of Biotechnology for Developing Biopharmaceuticals 7 1.3 Historical Perspective of Pharmaceutical Biotechnology 8 1.4 Distinctions between Chemical Drugs Versus Biopharmaceuticals 8 1.5 Summary 10 2 Distinctions of Biologic Versus Small Molecule Platforms in Drug Development 13 Abstract 13 2.1 Introduction 14 2.2 Transforming New Molecules into Drugs: The Drug Development Process 14 2.3 Key Differences between Biotechnology and Chemical Products 16 2.4 Current Trends in Drug Development 18 2.5 Summary 22 3 Financing Biologic Drug Development 23 Abstract 23 3.1 Introduction 24 3.2 The Role of the Orphan Drug Act 27 3.3 Clinical Leverage Strategy in Accelerating Drug Development 30 3.4 Therapeutic Target Considerations 32 3.5 Evolving Trends 34 3.6 Summary 36 4 Application of Biotechnology in Drug Discovery and Early Development 39 Abstract 39 4.1 Introduction 40 4.2 Data Mining, Molecular Cloning, and Characterization 40 4.3 Optimization of Cell Expression Systems and Product Yield 50 4.4 Molecular Optimization 51 4.5 Proteins and Genes as Targets for Drug Discovery and Development 56 4.6 Summary 58 5 Large-Scale Production of Recombinant Proteins 63 Abstract 63 5.1 Introduction 64 5.2 Yield Optimization in Genetic Constructs and Host Cells 65 5.3 Large-Scale Cultivation of Host Cells 66 5.4 Downstream Processing and Purification 70 5.5 Quality Assurance and Quality Control 75 5.6 Summary 77 6 Clinical Pharmacology, Toxicology, and Therapeutic Dosage and Response 79 Abstract 79 6.1 Introduction 80 6.2 Clinical Pharmacology and Toxicology 80 6.3 Dose and Therapeutic Response 95 6.4 Dosage Form and Route of Administration 97 6.5 Summary 99 7 Clinical Evaluation and Regulatory Approval and Enforcement of Biopharmaceuticals 103 Abstract 103 7.1 Introduction: Biologic Drug Development and Approval 104 7.2 Licensing of Biological Products 104 7.3 Preclinical and Clinical Testing 107 7.4 FDA Review and Approval Process 114 7.5 Regulatory Enforcement 118 7.6 Globalization of Drug Approval (Chien*) 118 7.7 Summary 122 8 Pharmacoeconomics and Drug Pricing (Garrison*) 125 Abstract 125 8.1 Introduction: Pharmacoeconomics 126 8.2 Cost-Effectiveness: Assessing the Value of Biopharmaceuticals 126 8.3 The Cost of Developing Biopharmaceuticals 128 8.4 Pricing Biopharmaceuticals 131 8.5 Drug Development Incentives 133 8.6 Economics of Biosimilars 133 8.7 Economic Impact of Personalized Medicine 134 8.8 Summary and Future Challenges 135 Part II Therapeutic and Clinical Applications of Biopharmaceu ticals—Proteins and Nucleic Acids 137 9 Antibodies and Derivatives 139 Abstract 139 Section One 140 9.1 Molecular Characteristics and Therapeutic Applications 140 9.1.1 Introduction 140 9.1.2 Historical Perspective—Discovery, Classification, Biodistribution, and Physiological Characteristics of Antibody Molecules 140 9.1.3 Gamma Globulin and Hyperimmune Globulin 144 9.1.4 Monoclonal Antibodies—From Mouse, Mouse-Human Chimeric, Humanized, to Human Monoclonal Antibodies 145 9.1.5 Antibody Derivatives 147 9.1.6 Disposition of Antibodies 149 9.1.7 Extravascular Tissue Penetration 155 9.1.8 Mechanisms of Antibody Bioactivities 156 9.1.9 Antibody Conjugates 156 9.1.10 Antibodies and Derivatives in Development 158 9.1.11 Summary 159 Section Two 162 9.2 Antibodies and Derivatives Monographs List 162 9.3 Antibodies and Derivatives Monographs 163 10 Hematopoietic Growth and Coagulation Factors 211 Abstract 211 Section One 212 10.1 Molecular Characteristics and Therapeutic Applications 212 10.1.1 Introduction 212 10.1.2 Hematopoietic Growth and Coagulation Factors 212 10.1.3 Therapeutic Use of Hematopoietic Growth Factors (Molineux, Elliott*) 218 10.1.4 Therapeutic Use of Coagulation and Anticoagulation Factors 225 10.1.5 Summary 229 Section Two 231 10.2 Hematopoietic Growth and Coagulation Factors List 231 10.3 Hematopoietic Growth and Coagulation Factors Monographs 231 11 Cytokines and Interferons 251 Abstract 251 Section One 252 11.1 Molecular Characteristics and Therapeutic Applications 252 11.1.1 Introduction 252 11.1.2 Interleukins as Immunotherapeutics 252 11.1.3 Interferon Biology and Cancer Therapy (Tiu, Koon, Borden*) 256 11.1.4 Interferons as Antiviral Therapy 271 11.1.5 Interferons in Multiple Sclerosis 275 11.1.6 Summary 280 Section Two 288 11.2 Cytokines and Interferons Monographs List 288 11.3 Cytokines and Interferons Monographs 288 12 Hormones 307 Abstract 307 Section One 308 12.1 Molecular Characteristics and Therapeutic Applications 308 12.1.1 Introduction 308 12.1.2 Peptide Hormones and Clinical Significance 308 12.1.3 Therapeutic Application of Recombinant and Synthetic Hormones 309 12.1.4 Summary 318 Section Two 320 12.2 Hormones Monographs List 320 12.3 Hormones Monographs 320 13 Enzymes 357 Abstract 357 Section One 358 13.1 Molecular Characteristics and Therapeutic Applications 358 13.1.1 Introduction 358 13.1.2 Enzyme Replacement Therapy 359 13.1.3 Enzymes as Therapeutic Agents 365 13.1.4 Summary and Future Prospects 368 Section Two 370 13.2 Enzymes Monographs List 370 13.3 Enzymes Monographs 370 14 Vaccines (Hu, Ho*) 389 Abstract 389 Section One 390 14.1 Molecular Characteristics and Therapeutic Applications 390 14.1.1 Vaccines and Their Impact on Human Health 390 14.1.2 How Vaccines Work: Interplay among Immune System, Diseases, and Vaccines 393 14.1.3 Traditional Vaccine Approaches 394 14.1.4 Subcellular and Recombinant Subunit Vaccines 395 14.1.5 Vaccine Adjuvants 398 14.1.6 Mode and Route of Vaccine Delivery 400 14.1.7 Future Directions 403 14.1.8 Summary 405 Section Two 409 14.2 Vaccines Monographs List 409 14.3 Vaccines Monographs 409 15 Other Biopharmaceutical Products 417 Abstract 417 15.1 Other Biopharmaceutical Products Monographs List 418 15.2 Other Biopharmaceutical Products Monographs 418 Part III Future Directions 425 16 Advanced Drug Delivery 427 Abstract 427 16.1 Introduction 428 16.2 Drug Therapeutic Index and Clinical Impact 429 16.3 Routes of Therapeutic Protein Administration 430 16.4 Physiological and Mechanistic Approaches 436 16.5 Approaches Using Devices 458 16.6 Molecular Approaches 460 16.7 Summary 465 17 Advances in Personalized Medicine: Pharmacogenetics in Drug Therapy 471 Abstract 471 17.1 Introduction to Interindividual Variation 472 17.2 Historical Perspective on Pharmacogenetics in Drug Safety and Efficacy 473 17.3 Pharmacogenetics in Drug Disposition and Pharmacokinetics 478 17.4 Pharmacogenetics in Drug Effects and Pharmacodynamics 483 17.5 Individualized Gene-Based Medicine: A Mixed Blessing 487 17.6 Current and Future Prospects of Pharmacogenetics 490 17.7 Summary 492 18 Gene and Cell Therapy 495 Abstract 495 18.1 Overview 496 18.2 General Strategies in Gene and Cell Therapy 499 18.3 Gene and Cell Therapy for Select Medical Conditions 501 18.4 Gene Therapy Research, Development, and Clinical Use (Sullivan*) 506 18.5 Stem Cells in Regenerative Medicine and Diagnostics (Kelly*) 509 18.6 Summary 513 19 Integration of Discovery and Development: The Role of Genomics, Proteomics, and Metabolomics 517 Abstract 517 19.1 Overview 518 19.2 Integration of Discovery and Development of Therapeutic Candidates 520 19.3 Genomics: The First Link between Sequences and Drug Targets 521 19.4 Proteomics: From Sequences to Functions 524 19.5 Metabolomics: Metabolic Profile Elucidation 528 19.6 Integrating Genomic, Proteomic, and Metabolomic Tools to Accelerate Drug Development 530 19.7 Summary 532 20 Pharmacoeconomics, Outcome, and Health Technology Assessment Research in Drug Development 535 Abstract 535 20.1 Introduction: Health-Care Decisions and Health Outcomes 536 20.2 Integration of Pharmacoeconomic Outcome Research in Clinical Drug Development 538 20.3 Regional Differences in the Type of Evidence and Value Data Essential for Health-Care and Reimbursement Decisions 541 20.4 Biopharmaceutical Company Strategies 542 20.5 Summary 545 20.6 Acknowledgments 546 21 Future Prospects 547 Abstract 547 21.1 Progress and Benefits in Transforming Proteins and Genes into Biopharmaceuticals 548 21.2 Genomic Information Improves Safety and Production Cost of Biopharmaceuticals 548 21.3 The Business of Biopharmaceuticals and Economic Impacts 549 21.4 Influence of Biopharmaceuticals on Pharmaceutical Research, Development, and the Drug Industry 549 21.5 Public–Private Partnership in Financial and Regulatory Support to Improve Translational Success 550 21.6 Biopharmaceuticals and Public Health Benefits 551 21.7 Public Participation and Influence on Biopharmaceutical Development 551 21.8 Outlook 552 Appendix I. Dosage Form, Pharmacokinetics, and Disposition Data 555 Appendix II. Molecular Characteristics and Therapeutic Use 581 Appendix III. Nomenclature of Biotechnology Products 617 Appendix IV. Other Information 621 Index 633 Color plate section is located between pages 210 and 211.

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Book SynopsisTable of Contents1. Biochemistry and the Organization of Cells. 2. Water: The Solvent for Biochemical Reactions. 3. Amino Acids and Peptides. 4. The Three-Dimensional Structure of Proteins. 5. Protein Purification and Characterization Techniques. 6. The Behavior of Proteins: Enzymes. 7. The Behavior of Proteins: Enzymes, Mechanisms, and Control. 8. Lipids and Proteins Are Associated in Biological Membranes. 9. Nucleic Acids: How Structure Conveys Information. 10. Biosynthesis of Nucleic Acids: Replication. 11. Transcription of the Genetic Code: The Biosynthesis of RNA. 12. Protein Synthesis: Translation of the Genetic Message. 13. Nucleic Acid Biotechnology Techniques. 14. Viruses, Cancer and Immunology. 15. The Importance of Energy Changes and Electron Transfer in Metabolism. 16. Carbohydrates. 17. Glycolysis. 18. Storage Mechanisms and Control in Carbohydrate Metabolism. 19. The Citric Acid Cycle. 20. Electron Transport and Oxidative Phosphorylation. 21. Lipid Metabolism. 22. Photosynthesis. 23. The Metabolism of Nitrogen. 24. Integration of Metabolism: Cellular Signaling. Answers. Glossary. Index.

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Book SynopsisDie 3., korrigierte Auflage der bewährten Einführung in die Biochemie präsentiert erneut die Schlüsselkonzepte des Faches in verständlicher Form - kompakt, anschaulich, didaktisch durchdacht. Das bestens eingeführte Lehrbuch richtet sich an Studierende der Medizin, Biologie und Chemie, die einen fundierten und leicht zugänglichen Überblick über das Gesamtgebiet der Biochemie suchen, ohne in der Fülle der modernen biochemisch-molekularbiologischen Erkenntnisse den Boden unter den Füßen zu verlieren. Dem Autor gelingt es, die Grundlagen, Leitmotive und Schlüsselkonzepte der Biochemie herauszuarbeiten und dem Leser somit das Rüstzeug für erfolgreiche Prüfungen wie auch für die spätere Vertiefung in die weiterführende Literatur zu liefern. Konzeptionell durchdacht vermittelt das Buch in fünf Teilen I: Molekulare Architektur des Lebens II: Struktur und Funktion von Proteinen III: Speicherung und Ausprägung von Erbinformation IV: Signaltr ansduktion und zelluläre FunktionV: Energiewandlung und Biosynthesenicht nur das Grundwissen der Biochemie, sondern veranschaulicht auch das Gedankengebäude dieser dynamischen Disziplin. Schlüsselbegriffe und wichtige Biomoleküle sind im Text hervorgehoben. Eine Fülle von Querverweisen schafft Zusammenhänge zwischen den Abschnitten und Kapiteln. Ausformulierte Zwischenüberschriften können als Merksätze zur schnellen Rekapitulation dienen. Maus-Symbole verweisen auf Websites, die in einer umfangreichen Link-Sammlung im Internet zur Verfügung stehen und weiterführende Informationen zu einzelnen Themen liefern. Zahlreiche Exkurse werfen Schlaglichter auf interessante biochemische und pathobiochemische Phänomene - ob es sich um die molekulare Basis menschlicher Krankheiten, wichtige Untersuchungsmethoden, spezielle Molekülstrukturen oder zellbiologische Prozesse handelt. Zur schnellen Orientierung sind die wichtigsten Biomoleküle nach Gruppen geordnet auf 15 ganzseitigen Tafeln dargestellt sowie sämtliche im Buch aufgeführten Hormone mit ihren Rezeptoren und Signalwegen als kompakte Übersicht im Tafelteil präsentiert.Eine Besonderheit des Buches sind die mehr als tausend Grafiken, die eine unverwechselbare Handschrift - plakativ, klar, verständlich - tragen und in dichter Folge die im Text vorgestellten Phänomene und Prozesse veranschaulichen.Die vorgegebenen Ausbildungsinhalte für Mediziner in der Biochemie sind durch das Buch nahezu vollständig abgedeckt. Auch das - in der neuen Approbationsordnung betonte - Zusammenwachsen von Biochemie und Molekularbiologie spiegelt sich im Buch wider.Mit diesem klar gegliederten und verständlich geschriebenen Lehrbuch macht es einfach Spaß, Biochemie zu lernen!Table of ContentsTeil I: Molekulare Architektur des Lebens1. Chemie - Basis des Lebens2. Biomoleküle - Bausteine des Lebens3. Zellen - Organisation des LebensTeil II: Struktur und Funktion von Proteinen4. Proteine - Werkzeuge der Zelle5. Ebenen der Proteinarchitektur6. Proteine auf dem Prüfstand7. Erforschung der Proteinstruktur8. Proteine als Strukturträger9. Proteine als molekulare Motoren10. Dynamik sauerstoffbindender Proteine11. Proteine als molekulare Katalysatoren12. Mechanismen der Katalyse13. Regulation der Enzymaktivität14. Enzymkaskaden des Bluts15. Evolution der ProteineTeil III: Speicherung und Ausprägung von Erbinformation16. Nucleinsäuren - Struktur und Organisation17. Transkription - Umschrift genetischer Information18. Translation - Decodierung genetischer Information19. Posttranslationale Prozessierung und Sortierung von Proteinen20. Kontrolle der Genexpression21. Replikation - Kopieren genetischer Information22. Analyse und Manipulation von Nucleinsäuren23. Veränderung genetischer InformationTeil IV: Signaltransduktion und zelluläre Funktion24. Struktur und Dynamik biologischer Membranen25. Proteine als Funktionsträger von Biomembranen26. Ionenpumpen und Membrankanäle27. Prinzipien der interzellulären Kommunikation 28. Signaltransduktion über G-Protein-gekoppelte Rezeptoren29. Signaltransduktion über enzymgekoppelte Rezeptoren30. Hormonelle Steuerung komplexer Systeme31. Molekulare Physiologie des Gastrointestinaltrakts32. Neuronale Erregung und Transmission33. Struktur und Dynamik des Cytoskeletts34. Zellzyklus und programmierter Zelltod35. Molekulare Basis von Krebsentstehung und Krebsbekämpfung36. Angeborenes und erworbenes Immunsystem37. Erforschung und Entwicklung neuer ArzneistoffeTeil V: Energiewandlung und Biosynthese38. Grundprinzipien des Metabolismus39. Glykolyse - Prototyp eines Stoffwechselwegs40. Citratzyklus - zentrale Drehscheibe des Metabolismus41. Oxidative Phosphorylierung - Elektronentransport und ATP-Synthese42. Pentosephosphatweg - ein adaptives Stoffwechselmodul43. Gluconeogenese und Cori-Zyklus44. Biosynthese und Abbau von Glykogen45. Fettsäuresynthese und ß-Oxidation46. Biosynthese von Cholesterin, Steroiden und Membranlipiden47. Abbau von Aminosäuren und Harnstoffzyklus48. Biosynthese von Aminosäuren und Häm49. Bereitstellung und Verwertung von Nucleotiden50. Koordination und Integration des Stoffwechsels

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Book SynopsisPraise for the prior editionThe author has done a magnificent job this book is highly recommended for introducing biophysics to the motivated and curious undergraduate student.?Contemporary Physicsa terrific text will enable students to understand the significance of biological parameters through quantitative examples?a modern way of learning biophysics. ?American Journal of PhysicsA superb pedagogical textbook Full-color illustrations aid students in their understanding ?Midwest Book ReviewThis new edition provides a complete update to the most accessible yet thorough introduction to the physical and quantitative aspects of biological systems and processes involving macromolecules, subcellular structures, and whole cells. It includes two brand new chapters covering experimental techniques, especially atomic force microscopy, complementing the updated coverage of mathematical and compTable of ContentsI. Introduction, Approach, and Tools 1 Introduction to a New World 2 How (Most) Physicists Approach Biophysics 3 Math Tools: First Pass II. Structure and Function 4 Water 5 Structures: From 0.1 to 10 nm and Larger 6 First Pass at Supramolecular Structures: Assemblies of Biomolecules 7 Putting a Cell Together: Physical Sketch III. Biological Activity: Quantum Microworld 8 Quantum Primer 9 Light, Life and Measurement 10 Photosynthesis 11 Direct Ultraviolet Effects on Biological Systems IV. Biological Activity: (Classical) Microworld 12 Classical Biodynamics and Biomechanics 13 Random Walks, Diffusion, and Polymer Conformation 14 Statistical Physics and Thermodynamics Primer 15 Reactions: Physical View 16 Molecular Machines: Introduction 17 Assembly 18 Preparation for Experimental Biophysics 19 Atomic Force Microscopy

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Book SynopsisNow in its sixth edition, Biochemistry and Molecular Biology provides the perfect balance between detail and conceptual understanding. Maintaining the much-praised clarity of previous editions, this edition incorporates both new techniques and pivotal discoveries in a succinct, easy-to-digest way, using updated figures and diagrams to help explain complex processes.Updated content on the manipulation of DNA and genes reflects the rapid introduction of new methods in contemporary research, and incorporates up-to-date discussions of recent developments such as gene editing. Chapter summaries are logically laid out, forming bulleted lists which provide students with a consolidation of difficult concepts and progressively guide them through the specifics whilst keeping the big picture in mind. Additional ''find out more'' sections provide helpful problem-solving support and the further reading is divided into types to cater for broader learning needs.With an integrated approach covering boTrade ReviewEasy to read with good use of simple figures and plenty of internal cross-references to other chapters or relevant pages. I was impressed with the inclusion of some very up to date findings. * Dr Peter Morris, School of Life Sciences, Heriot-Watt University *I don't know of any other biology/biochemistry book that explains DNA replication as well as this one. * Lynn Rogers, School of Molecular and Biomedical Science, Adelaide University *The style is very clear, logical and systematic. The diagrams complement the text well. * Dr Momna Hejmadi, Department of Biology and Biochemistry, University of Bath *Good entry level biochemistry textbook that gives students an overview of the diversity of biochemistry and that introduces abstract concepts in a well-explained and accessible way. * Dirk Wildeboer, Natural Sciences, Middlesex University *This textbook presents classical biochemistry material with a balanced emphasis on details and conceptual understanding. Explanations are given in a conversational manner so that students are not distracted by an over-whelming amount of new terminology. * Amanda Storm, Biology, James Madison University *Table of ContentsPart 1: Basic concepts of life 1: The basic molecular themes of life 2: Cells and viruses 3: Energy considerations in biochemistryPart 2: Structure and function of proteins and membranes 4: The structure of proteins 5: Methods in protein investigation 6: Enzymes 7: The cell membrane and membrane proteins 8: Muscle contraction, the cytoskeleton, and molecular motorsPart 3: Metabolism and nutrition 9: General principles of nutrition 10: Food digestion, absorption and distribution to the tissues 11: The storage fuels: Mechanisms of transport, storage, and mobilization of carbohydrate and fat 12: Principles of energy release from food 13: Glycolysis, the TCA cycle, and the electron transport system 14: Energy release from fat 15: An alternative pathway of glucose oxidation: The pentose phosphate pathway 16: Synthesis of glucose (gluconeogenesis) 17: Synthesis of fat and related compounds 18: Nitrogen metabolism: amino acid metabolism 19: Nitrogen metabolism: nucleotide metabolism 20: Mechanisms of metabolic control and their applications to metabolic integration 21: Raising electrons of water back up the energy scale: photosynthesisPart 4: Information storage and utilization 22: The genome 23: DNA synthesis, repair and recombination 24: Gene transcription 25: Protein synthesis and controlled protein breakdown 26: Control of gene expression 27: Protein sorting and delivery 28: Manipulating DNA and genesPart 5: Cells and tissues 29: Cell signalling 30: The cell cycle, cell division, cell death and cancerPart 6: Protective mechanisms against disease 31: Blood clotting, xenobiotic metabolism, and reactive oxygen species 32: The immune system

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Book SynopsisDespite competition from an ever-growing range of alternative adult beverages, beer remains a vastly important beverage globally. There is a huge diversity of beer styles, drinks suited not only to refreshment and delight in themselves, but also to suit any drinking occasion, including alongside food of all types. There is nutritional value in beer and evidence that, consumed responsibly, it can be a valuable part of a well-balanced diet. This relates to the wholesomeness of the basic materials employed for the brewing of beer, notably malt and hops, but also the nature of the longstanding processes that are employed in converting cereals such as barley and wheat into malt and thence through the time-honored stages of brewing. This book explains these issues- history, nature and complexity of the modern brewing business, types of beer, quality attributes of beer, the underpinning processes, and much more. Any reader, from those who know little about the subject through to the beer aficTrade ReviewThis book is a good read for anyone interested in the science of beer or its consumption." -Chemistry WorldTable of ContentsForeword by Dr Tim Cooper Preface Preface to the Third Edition Preface to the Second Edition Preface to the First Edition Acknowledgments Introduction Chapter 1: FERTILE CRESCENT TO FRANKFURT: The World of Beer and Breweries Chapter 2: A BRIEF HISTORY OF BEER Chapter 3: BARLEY TO BARREL: The Basics of Malting and Brewing Chapter 4: PERSONAL CHOICE: Beer Styles Chapter 5: SEE, SMELL, SAVOR: The Quality of Beer Chapter 6: BEER AND BODY Chapter 7: THE HEART AND SOUL OF BEER: Malt Chapter 8: WATER: And Genuine Terroir Chapter 9: RICE, CORN AND OTHER TOUCHY SUBJECTS Chapter 10: THE WICKED AND PERNICIOUS WEED: Hops Chapter 11: HOT STUFF: The Brewhouse Chapter 12: GODESGOOD: Yeast and Fermentation Chapter 13: REFINING MATTERS: Downstream Processing Chapter 14: ENVIRONMENTAL MATTERS Chapter 15: MEASURE FOR MEASURE: How Beer Is Analyzed Chapter 16: REVERENCE FOR BEER Chapter 17: TO THE FUTURE: Malting and Brewing in Years to Come Glossary Further Study Index

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Book SynopsisWritten by biomedical scientists and clinicians to disseminate the fundamental scientific principles that underpin clinical medicine, this new edition provides a clear, easily digestible account of basic cell physiology and biochemistry, and an investigation of the traditional piers of medicine.Trade ReviewReview from previous edition I have no doubt that OHMS is one of the best books I have ever bought. * Medical Student, University of Edinburgh *I would certainly recommend this book for clinical students who want to refresh some basic sciences later in their education. This is a reliable reference book which I think will serve me very well into my clinical years and I shall keep by my desk for those moments where I need to find a long-ago learnt and now-forgotten fact! * Cambridge Medicine Journal *This book represents excellent value for money and is a superb offering which is now in a mature third edition. * Dr Harry Brown, Pavilion Health Today *Table of Contents1: Cellular structure and function 2: Cellular metabolism 3: Molecular and medical genetics 4: Nerve and muscle 5: Musculoskeletal system 6: Respiratory and cardiovascular systems 7: Urinary system 8: Digestive system 9: Endocrine organs 10: Reproduction and development 11: Neuroanatomy and neurophysiology 12: Infection and immunity 13: Growth of tissues and organs 14: Medicine and society 15: Techniques of medical sciences

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Book Synopsis Exercise Biochemistry brings an admittedly difficult and technical subject to life. Extremely user- and student-friendly, it is written in conversational style by Vassilis Mougios, who poses and then answers questions as if in conversation with a student. Mougios does an excellent job of making the information interesting by using simple language without compromising scientific accuracy and content. He also uses ample analogies, related works of art, and numerous illustrations to drive home his points for readers. The result is that Exercise Biochemistry is a highly informative and illuminating text on the effects of exercise on molecular-level functioning. It presents the basics of biochemistry as well as in-depth coverage of exercise biochemistry. The book uses key terms, sidebars, and questions and problems posed at the end of each chapter to facilitate learning. It also covers metabolism, endocrinology, and assessment all in one volume, unlike other exerTable of Contents Part I. Biochemistry Basics Chapter 1. Introduction 1.1 Chemical Elements 1.2 Chemical Bonds 1.3 Molecules 1.4 Ions 1.5 Radicals 1.6 Polarity Influences Miscibility 1.7 Solutions 1.8 Chemical Reactions 1.9 Chemical Equilibrium 1.10 pH 1.11 Acid-Base Interconversions 1.12 Buffer Systems 1.13 Classes of Biological Substances 1.14 Classes of Nutrients 1.15 Cell Structure Chapter 2. Metabolism 2.1 Free-Energy Changes of Metabolic Reactions 2.2 Determinants of Free-Energy Change 2.3 ATP, the Energy Currency of Cells 2.4 Phases of Metabolism 2.5 Redox Reactions 2.6 Overview of Catabolism Chapter 3. Proteins 3.1 Amino Acids 3.2 The Peptide Bond 3.3 Primary Structure of Proteins 3.4 Secondary Structure 3.5 Tertiary Structure 3.6 Denaturation 3.7 Quaternary Structure 3.8 Protein Function 3.9 Oxygen Carriers 3.10 Myoglobin 3.11 Hemoglobin Structure 3.12 The Wondrous Properties of Hemoglobin 3.13 Enzymes 3.14 The Active Site 3.15 How Enzymes Speed up Metabolic Reactions 3.16 Factors Affecting the Rate of Enzyme Reactions Chapter 4. Nucleic Acids and Gene Expression 4.1 Introducing Nucleic Acids 4.2 Flow of Genetic Information 4.3 Deoxyribonucleotides, the Building Blocks of DNA 4.4 Primary Structure of DNA 4.5 The Double Helix of DNA 4.6 The Genome of Living Organisms 4.7 DNA Replication 4.8 Mutations 4.9 RNA 4.10 Transcription 4.11 Delimiting Transcription 4.12 Genes and Gene Expression 4.13 Messenger RNA 4.14 Translation 4.15 The Genetic Code 4.16 Transfer RNA 4.17 Translation Continued 4.18 In the Beginning, RNA? Chapter 5. Carbohydrates and Lipids 5.1 Carbohydrates 5.2 Monosaccharides 5.3 Oligosaccharides 5.4 Polysaccharides 5.5 Carbohydrate Categories in Nutrition 5.6 Lipids 5.7 Fatty Acids 5.8 Triacylglycerols 5.9 Phospholipids 5.10 Steroids 5.11 Cell Membranes Chapter 6. Vitamins and Minerals 6.1 Water Soluble Vitamins 6.2 Fat Soluble Vitamins 6.3 Metal Minerals 6.4 Nonmetal Minerals 6.5 Elements in the Human Body Part II. Biochemistry of the Neural and Muscular Processes of Movement Chapter 7. Neural Control of Movement 7.1 Two Ways of Transmission of Nerve Signals 7.2 The Resting Potential 7.3 The Action Potential 7.4 Propagation of an Action Potential 7.5 Transmission of a Nerve Impulse from One Neuron to Another 7.6 Birth of a Nerve Impulse 7.7 The Neuromuscular Junction 7.8 Changes in Motor Neuron Activity During Exercise 7.9 A Lethal Arsenal at the Service of Research Chapter 8. Muscle Activity 8.1 Structure of a Muscle Cell 8.2 The Sliding-Filament Theory 8.3 The Wondrous Properties of Myosin 8.4 Myosin Structure 8.5 Actin 8.6 Sarcomere Architecture 8.7 Mechanism of Force Generation 8.8 Myosin Isoforms and Muscle Fiber Types 8.9 Control of Muscle Contraction by Ca2+ 8.10 Excitation-Contraction Coupling Part III. Exercise Metabolism III.1 Principles of Exercise Metabolism III.2 Exercise Parameters III.3 Experimental Models Used to Study Exercise Metabolism III.4 Five Means of Metabolic Control in Exercise III.5 Four Classes of Energy Sources in Exercise Chapter 9. Compounds of High Phosphoryl Transfer Potential 9.1 The ATP-ADP Cycle 9.2 The ATP-ADP Cycle in Exercise 9.3 Phosphocreatine 9.4 Watching Exercise Metabolism 9.5 Loss of AMP by Deamination 9.6 Purine Degradation Chapter 10. Carbohydrate Metabolism in Exercise 10.1 Carbohydrate Digestion and Absorption 10.2 Glycogen Content of the Human Body 10.3 Glycogenesis 10.4 Glycogenolysis 10.5 Exercise Speeds Up Glycogenolysis in Muscle 10.6 The Cyclic-AMP Cascade 10.7 Recapping the Effect of Exercise on Muscle Glycogen Metabolism 10.8 Glycolysis 10.9 Exercise Speeds Up Glycolysis in Muscle 10.10 Pyruvate Oxidation 10.11 Exercise Speeds Up Pyruvate Oxidation in Muscle 10.12 The Citric Acid Cycle 10.13 Exercise Speeds Up the Citric Acid Cycle in Muscle 10.14 The Electron Transport Chain 10.15 Oxidative Phosphorylation 10.16 Energy Yield of the Electron Transport Chain 10.17 Energy Yield of Carbohydrate Oxidation 10.18 Exercise Speeds Up Oxidative Phosphorylation in Muscle 10.19 Lactate Production in Muscle During Exercise 10.20 Is Lactate Production a Cause of Fatigue? 10.21 Is Lactate Production Due to a Lack of Oxygen? 10.22 Features of the Anaerobic Carbohydrate Catabolism 10.23 Utilizing Lactate 10.24 Gluconeogenesis 10.25 A Shortcut in Gluconeogenesis 10.26 Exercise Speeds Up Gluconeogenesis in the Liver 10.27 The Cori Cycle 10.28 Exercise Speeds Up Glycogenolysis in the Liver 10.29 Control of the Plasma Glucose Concentration in Exercise 10.30 Blood Lactate Accumulation 10.31 Blood Lactate Decline 10.32 “Thresholds” Chapter 11. Lipid Metabolism in Exercise 11.1 Triacylglycerol Digestion, Absorption, and Distribution 11.2 Digestion, Absorption, and Distribution of Other Lipids 11.3 Fat Content of the Human Body 11.4 Triacylglycerol Synthesis in Adipose Tissue 11.5 Lipolysis 11.6 Exercise Speeds Up Lipolysis in Adipose Tissue 11.7 Exercise Speeds Up Lipolysis in Muscle 11.8 Fate of the Lipolytic Products During Exercise 11.9 Fatty Acid Degradation 11.10 Energy Yield of Fatty Acid Oxidation 11.11 Degradation of Unsaturated Fatty Acids 11.12 Degradation of Odd-Number Fatty Acids 11.13 Fatty Acid Synthesis 11.14 Synthesis of Fatty Acids Other Than Palmitate 11.15 Exercise Speeds Up Fatty Acid Oxidation in Muscle 11.16 Changes in the Plasma Fatty Acid Concentration and Profile During Exercise 11.17 Interconversion of Lipids and Carbohydrates 11.18 Brown Adipose Tissue 11.19 Plasma Lipoproteins 11.20 A Lipoprotein Odyssey 11.21 Effects of Exercise on Plasma Triacylglycerols 11.22 Effects of Exercise on Plasma Cholesterol 11.23 Exercise Increases Ketone Body Formation Chapter 12. Protein Metabolism in Exercise 12.1 Processing of Dietary Proteins 12.2 Protein Content of the Human Body 12.3 Protein Turnover 12.4 Effects of Exercise on Protein Turnover 12.5 Amino Acid Degradation 12.6 Amino Acid Synthesis 12.7 Effects of Exercise on Amino Acid Metabolism in Muscle 12.8 Effects of Exercise on Amino Acid Metabolism in the Liver 12.9 The Urea Cycle 12.6 Amino Acid Synthesis 12.10 Plasma Amino Acid, Ammonia, and Urea Concentrations During Exercise 12.11 Contribution of Proteins to the Energy Expenditure of Exercise 12.12 Effects of Training on Protein Turnover Chapter 13. Effects of Exercise on Gene Expression 13.1 Stages in the Control of Gene Expression 13.2 Stages in the Control of Gene Expression Affected by Exercise 13.3 Kinetics of a Gene Product After Exercise 13.4 Exercise-Induced Changes That May Modify Gene Expression 13.5 Mechanisms of Exercise-Induced Muscle Hypertrophy 13.6 Mechanisms of Exercise-Induced Increase in Muscle-Mitochondrial Content 13.7 Exercise and Epigenetics Chapter 14. Integration of Exercise Metabolism 14.1 Interconnections of Metabolic Pathways 14.2 Energy Systems 14.3 Energy Sources in Exercise 14.4 Choice of Energy Sources During Exercise 14.5 Effect of Exercise Intensity on the Choice of Energy Sources 14.6 Effect of Exercise Duration on the Choice of Energy Sources 14.7 Interplay of Duration and Intensity: Energy Sources in Running and Swimming 14.8 Effect of the Exercise Program on the Choice of Energy Sources 14.9 Sex Differences in the Choice of Energy Sources During Exercise 14.10 How Sex Influences the Choice of Energy Sources During Exercise 14.11 Effect of Age on the Choice of Energy Sources During Exercise 14.12 Effect of Carbohydrate Intake on the Choice of Energy Sources During Exercise 14.13 Effect of Fat Intake on the Choice of Energy Sources During Exercise 14.14 Adaptations of the Proportion of Energy Sources During Exercise to Endurance Training 14.15 How Endurance Training Modifies the Proportion of Energy Sources During Exercise? 14.16 Adaptations of Energy Metabolism to Resistance and Sprint Training 14.17 Adaptations of Exercise Metabolism to Interval Training 14.18 Effect of the Genome on the Choice of Energy Sources in Exercise 14.19 Muscle Fiber Type Transitions 14.20 Effects of Environmental Factors on the Choice of Energy Sources in Exercise 14.21 The Proportion of Fuels Can Be Measured Bloodlessly 14.22 Hormonal Effects on Exercise Metabolism 14.23 Redox State and Exercise Metabolism 14.24 Causes of Fatigue 14.25 Recovery of the Energy State After Exercise 14.26 Metabolic Changes in Detraining Chapter 15. Exercise to Fight Disease 15.1 Health, Disease, and Exercise 15.2 Exercise to Fight Cardiovascular Disease 15.3 Adaptations of the Heart to Training 15.4 Adaptations of the Vasculature to Training 15.5 Exercise to Fight Cancer 15.6 Diabetes, a Major Metabolic Upset 15.7 Exercise to Fight Diabetes 15.8 Obesity, a Health-Threatening Condition 15.9 Why Obesity Is Harmful 15.10 Exercise to Fight Obesity 15.11 Exercise to Fight Osteoporosis 15.12 Exercise to Fight Mental Dysfunction 15.13 The Detriments of Physical Inactivity 15.14 Exercise for Healthy Aging and Longevity 15.15 Benefits From Regular Exercise in Other Diseases 15.16 A Final Word on the Value of Exercise Part IV. Biochemical Assessment of Exercising Persons IV.1 The Blood IV.2 Aims and Scope of the Biochemical Assessment IV.3 The Reference Interval IV.4 Classes of Biochemical Parameters Chapter 16. Iron Status 16.1 Hemoglobin 16.2 Hematologic Parameters 16.3 Does Sports Anemia Exist? 16.4 Iron 16.5 Total Iron-Binding Capacity 16.6 Transferrin Saturation 16.7 Soluble Transferrin Receptor 16.8 Ferritin 16.9 Iron Deficiency Chapter 17. Metabolites 17.1 Lactate 17.2 Estimating the Anaerobic Lactic Capacity 17.3 Programming Training 17.4 Estimating Aerobic Endurance 17.5 Glucose 17.6 Triacylglycerols 17.7 Cholesterol 17.8 Recapping the Lipidemic Profile 17.9 Glycerol 17.10 Urea 17.11 Ammonia 17.12 Creatinine 17.13 Uric acid 17.14 Glutathione Chapter 18. Enzymes and Hormones 18.1 Enzymes 18.2 Creatine Kinase 18.3 Glutamyltransferase 18.4 Antioxidant Enzymes 18.5 Steroid Hormones 18.6 Cortisol 18.7 Testosterone 18.8 Overtraining Syndrome 18.9 Epilogue Part IV Summary

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Book SynopsisFocusing on the latest developments in the field, this will be the first book to describe the utilisation of lipids and proteins together for the development of functional materials in food engineering, environmental and industry applications.

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Book SynopsisWritten primarily for 16-19 year old students, this primer aims to extend students'' knowledge and inspire them to take their school-level learning further. It explores topics that are familiar from the curriculum and also introduces new ideas, giving students a first taste of the study of biology beyond school-level and demonstrating how concepts frequently encountered at school are relevant to and applied in current research. This is the ideal text to support students who are considering making the transition from studying biology at school to university. This is a concise, stimulating introduction to the fundamental biomolecules in cells and organisms, and the exciting ways biochemistry could be used to solve global problems, both now and in the future.Table of Contents1: Carbohydrates: Why life is sweet 2: Lipids and Proteins: the building blocks of a cell 3: Nucleotides and Nucleic Acids: Biology's information stores 4: Metabolism: Transforming energy and biomolecules 5: Maintaining a Metabolic Balance 6: Solving Tomorrow's Problems with Natural Products 7: Solving Tomorrow's Problems: Bioenergy and the environment

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Book SynopsisThis dictionary includes 10,000 A-Z entries on all areas of biomedicine. It also covers terms from related areas, including anatomy, genetics, pathology, pharmacology, and clinical medicine. Fully cross-referenced and with web links, this is a clear and authoritative guide to an increasingly important area of medicine.Table of ContentsPREFACE; A NOTE ON CONVENTIONS; LISTING OF NAVIGATIONAL ENTRIES; A DICTIONARY OF BIOMEDICINE; APPENDIX 1: THE GREEK ALPHABET; APPENDIX 2: SI UNITS; APPENDIX 3: SINGLE-LETTER CODES FOR AMINO ACIDS

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Book SynopsisAn enchanting biography of the most resonant and most necessary chemical element on Earth.Carbon. It is the building block of every cell that makes up every living thing. It is the essential component of the food we eat, the fuel we burn, the wood we use and the air we breathe. It is worth billions as a luxury and half a trillion as a necessity, but there are still mysteries to be solved about the element that can be both diamond and coal. Where does it come from, what does it do, and why, above all, does life need it?In Symphony in C, leading carbon scientist Robert M. Hazen takes us on a vibrant journey through the origin and evolution of life's most widespread element. The story unfolds in four movements Earth, Air, Fire and Water and transports us through nearly 14 billion years of cosmic history, explaining how carbon is formed in the hearts of stars and why all life forms earthbound or alien use it as the basis of their biology. Symphony in C is a sweeping chronicle of carbTrade ReviewPraise for Symphony in C ‘A valuable and welcome explanation of why we would do well to pay more attention to the sixth element – and of how much more remains to be discovered about its planetary role through time’ Nature ‘Covering topics from carbon’s ancient origins to the threats that carbon compounds pose to our future climate, Hazen’s book is a fascinating read. Symphony in C chronicles cutting-edge science that’s helping researchers make better sense of the carbon-rich world around us’ Science News ‘From the Big Bang to coal, carbohydrates, and ultra-strong high-tech nanofibers, Robert M. Hazen provides an illuminating and enjoyable guide to the remarkable odyssey of carbon, the element of life. Enjoy the trip!’ Andrew Knoll, Fisher Professor of Natural History, Harvard University ‘C is the element carbon. C is a musical note. Scientist-musician Hazen uses the element and the note to compose a symphonic masterpiece that reveals how the primitive life that began on our planet four billion years ago has evolved into Darwin’s “endless forms most beautiful“’ David W. Deamer, author of Assembling Life ‘Hazen’s virtuoso performance captures the wonder of the sixth element – from volcanic gases to al dente pasta to life’s very beginnings – while telling the wonderful stories about the people behind the discoveries’ Terry Plank, Arthur D. Storke Memorial Professor of Geochemistry, Columbia University ‘This book is an incredibly rich story of carbon and its role in of life. Hazen has outdone himself in delivering an engaging, edifying, great read. If you don’t know why carbon is important in your life, or even if you think you do, you should put down whatever you’re reading and get this book’ Paul G. Falkowski, author of Life’s Engines``

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Book SynopsisOffering a scientific approach to nutrition, this book describes the function of nutritional requirements at the cellular and molecular level. It includes a discussion of relevant aspects of physiology, food chemistry, toxicology, pediatrics, and public health.Table of ContentsClassification of Biological Structures Digestion and Absorption Nutrients that Resist or Escape Digestion Regulation of Energy Metabolism Energy Requirement Lipids Protein Vitamins Inorganic Nutrients Appendix A: Nutrition Methodology B: Cloning and Dot Blots

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Book SynopsisCovers various aspects of the biochemical abnormalities caused by various diseases and how they relate to the biochemical changes in the blood, urine, cerebrospinal fluid, joint fluids, other body fluids and in cells. This book provides the fundamental bases for understanding the biochemical changes which occur in disease processes.Table of ContentsConcepts of Normality in Clinical Biochemistry; DNA Technology; Carbohydrate Metabolism and Diabetes; Lipids and Ketones; Proteomics; Clinical Immunology; The Erythrocyte; The Porhyrins; Iron Metabolism; Hemostasis; The Leukocytes; Clinical Enzymology; Liver function; Pancreatic function; Gastrointestinal function; Skeletal Muscle Function; Kidney function; Fluid, Electrolyte and Acid-Base Balance; Pituitary Function; Adrenocortical function; Thyroid function; Reproductive Hormones; Clinical Nutrition; Calcium, Phosphorus and Magnesium Metabolism; Trace minerals; Vitamins; Tumor Markers; Lysosomal Storage Diseases; Cerebrospinal Fluid; Clinical toxicology; Clinical biochemistry of Laboratory Rodents and Rabbits; Clinical biochemistry of Avians; Appendixes: Clinical laboratory reference values in a number of animal species and some useful laboratory information

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Book SynopsisOffers a comprehensive survey text for biomedical engineering courses. This book helps biomedical engineers to understand the range of topics such as basic mathematical modeling; anatomy and physiology; electrical engineering, signal processing and instrumentation; biomaterials science and tissue engineering; and medical and engineering ethics.Table of Contents1. Biomedical Engineering: A Historical Perspective 2. Moral and Ethical Issues 3. Anatomy and Physiology 4. Biomechanics 5. Biomaterials 6. Tissue Engineering 7. Compartmental Modeling 8. Biochemical Reactions and Enzyme Kinetics 9. Bioinstrumentation 10. Biomedical Sensors 11. Biosignal Processing 12. Bioelectric Phenomena 13. Physiological Modeling 14. Biomedical Transport Processes 15. Radiation Imaging 16. Medical Imaging 17. Biomedical Optics and Lasers

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Book SynopsisTable of Contents1. The Structure and Function of Secondary Metabolites that are Secreted by Bacteria2. The Reagents, Supplies and Equipment that are Necessary to Grow Cultures of Bacteria in the Laboratory and to Purify Secreted Metabolites3. Overview of the Methods for Purification of Metabolites that are Secreted by Bacteria4. Absorption Spectrophotometry: Ultraviolet-visible and Infrared5. High-performance Liquid Chromatography6. Mass Spectrometry7. X-ray Crystallography8. Nuclear Magnetic Resonance Spectroscopy9. Exercises in Purifying and Characterizing a Quorum-sensing Signal10. Exercises in Purifying and Characterizing Iron-chelating Molecules11. Exercises in Purifying and Characterizing a Chloroplast-targeting Phytotoxin12. Designing your Own Experiments

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Book SynopsisBiochemistry: The Molecular Basis of Life is an intermediate, one-semester text written for students on degree pathways in Chemistry, Biology, and other Health and Life Sciences. Designed for students who need a solid introduction to biochemistry, but are not specializing in the subject, the text focuses on essential biochemical principles that underpin the modern life sciences, and offers the most balanced coverage of chemistry and biology of any text on the market. The text equips students with a complete view of the living state, emphasizes problem solving, and applies biochemical principles to the fields of Health, Agriculture, Engineering, and Forensics, to show students the relevance of their learning. McKee and McKee is respected for its balance of biology and chemistry, consistently placing biochemical principles into the context of the physiology of the cell and biomedical applications.Trade ReviewMcKee's Biochemistry is by far the best available textbook on the market for a one semester undergraduate Biochemistry course. It is very reader-friendly and has a better flow than most Biochemistry textbooks. This textbook goes beyond being a good reference book for students. Several features like key concepts, medical correlations, chapter summaries, 'Biochemistry in Perspective,' and end-of-chapter problems help guide learning and provide valuable study materials. * Niina Ronkainen, Benedictine University *McKee's Biochemistry is an excellent, one-semester biochemistry text that covers the major topics to an appropriate depth for health professions students. It is concise yet provides enough details to lay a solid biochemistry foundation. * Joe Deweese, Lipscomb University *The amount of material covered and the depth of the coverage is very good for a one-semester biochemistry course. The clinical examples to start each chapter are very nice and a good way to interest students in the material. The writing is at a level that will be helpful to students. * Michael Gunther, West Virginia University *Table of ContentsChapter Opening Vignettes Biochemistry in Perspective Essays Biochemistry in the Lab Boxes Preface General and Organic Chemistry Review Primer 1. Biochemistry: An Introduction 2. Living Cells 3. Water: The Matrix of Life 4. Energy 5. Amino Acids, Peptides, and Proteins 6. Enzymes 7. Carbohydrates 8. Carbohydrate Metabolism 9. Aerobic Metabolism I: The Citric Acid Cycle 10. Aerobic Metabolism II: Electron Transport and Oxidative Phosphorylation 11. Lipids and Membranes 12. Lipid Metabolism 13. Photosynthesis 14. Nitrogen Metabolism I: Synthesis 15. Nitrogen Metabolism II: Degradation 16. Integration of Metabolism 17. Nucleic Acids 18. Genetic Information 19. Protein Synthesis Appendix: Solutions Credits

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Book SynopsisYou are what you eat, and today's consumers care about the origins of their food. Artisanal food embodies those concerns, tailoring processes to raw materials to achieve the artisan's vision of the perfect product. The Science and Craft of Artisanal Food describes the science behind small and large-scale production of food, distinguishing artisanal production from normal commercial practice.Table of Contents1. Marketing Artisanal Products 2. Beer: Artfully Scientific on Every Level 3. Artist Winemaker 4. Artisanal Chocolate 5. Artisanal Coffee 6. Artisanal Cheese 7. The Chemistry and Flavor of Artisanal Honey 8. Industrial and Artisanal Olive Oil 9. Artisanal Fruits and Vegetables

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Book SynopsisThis work addresses the question of why minerals form in a large variety of organisms, from bacteria to man. The authors discuss the basic principles of mineral formation by organisms, and compare the various mineralization processes.Trade Review`The authors are to be congratulated on the hard work which has gone into a text which is highly informative, and does not get bogged down in details or dead-ends.' Mineralogical Society'... excellent book ... There is a wealth of new and newly synthesized information, including dozens of previously unpublished scanning electron micrographs ... This lucid and remarkably wide-ranging volume will provide a fine basis for the work to come.' Journal of Geology'The book provides an excellent introduction to the many aspects of the field, with extensive references to the literature. The text is generally very readable, with a smooth flow of words, and not excessively formal. Throughout the work the enthusiasm of the authors and their fascination with the topic shine through. Line drawings and photographs are well reproduced. The book is well bound and should survive frequent use.' C. Sancetta, Marine Geology, 110 (1993)Table of ContentsMinerals and macromolecules; Biomineralization processes; Protoctista; Cnidaria; Mollusca; Arthropoda; Echinodermata; Chordata; Some non-skeletal functions in biomineralization; Environmental influences on biomineralization; Evolution of biomineralization.

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Book SynopsisThis book is one of the first to apply engineering science and technology to biological cells and tissues that are electrically conducting and excitable. It describes the theory and a wide range of applications in both electric and magnetic fields. The similarities and differences between bioelectricity and biomagnetism are described in detail from the viewpoint of lead field theory. This book will enable readers to understand the properties of existing bioelectric and biomagnetic measurements and stimulation methods, and to design new systems. It includes carefully drawn illustrations and 500 references, and can be used as a textbook and as a reference.Trade Review"The book...is comprehensive and well-organized, and nicely edited and produced."--Engineering in Medicine and BiologyTable of ContentsPART I: ANATOMICAL AND PHYSIOLOGICAL BASIS OF BIOELECTROMAGNETISM; PART II: BIOELECTRIC SOURCES AND CONDUCTORS AND THEIR MODELLING; PART III: THEORETICAL METHODS IN BIOELECTROMAGNETISM; PART IV: ELECTRIC AND MAGNETIC MEASUREMENT OF THE ELECTRIC ACTIVITY OF NEURAL TISSUE; PART V: ELECTRIC AND MAGNETIC MEASUREMENT OF THE ELECTRIC ACTIVITY OF THE HEART; PART VI: ELECTRIC AND MAGNETIC STIMULATION OF NEURAL TISSUE; PART VII: ELECTRIC AND MAGNETIC STIMULATION OF THE HEART; PART VIII: MEASUREMENT OF THE INTRINSIC ELECTRIC PROPERTIES OF BIOLOGICAL TISSUES; PART IX: OTHER BIOELECTROMAGNETIC PHENOMENA

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Book SynopsisThis second and final volume of the biography of Hans Krebs covers his early years in England, 1933-1937, when he laid the foundations of our modern understanding of intermediary metabolism.Trade Review'This is not only a study of Krebs's research, it is also a comprehensive biography of Krebs's personal as well as scientific life ... These two volumes represent an extraordinary achievement, as a biography of a man, living in a time of turmoil and upheaval, who emerged as a great scientists. The story of both the man and the science is full and rewarding. Among studies of biochemists, I know of nothing in the least comparable with Holmes's achievement here, in its depth and breadth.' John T. Edsall, Harvard University, Nature, Vol. 366, December 1993'This is the second and concluding volume of Holmes' biography of Hans Krebs ... a remarkable ad detailed account of a significant period in the development of biochemistry, reflected in the work of a major "architect."' Nathaniel I. Berlin, University of Miami, JAMA, Vol. 271, No. 14, 1994'Tis is a substantial scientific biography covering four years of the life of Krebs ... There is an enormous amount of detail and the book will be of interest mainly to scientific historians.' Aslib Book Guide, Vol. 59, No. 6, June 1994Table of ContentsIntroduction ; 1. A new home for a career ; 2. Laboratory life in Cambridge ; 3. Progress under pressure ; 4. New moves ; 5. Arrivals and partings ; 6. The "Great Work" ; 7. Relocations and dismutations ; 8. Main routes and carriers ; 9. Full circle ; 10. Reflections ; Guide to structural formulas ; Notes

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Book SynopsisIn what will certainly be one of the key works in the emerging science of complexity, Kauffman here presents a brilliant new paradigm for evolutionary biology. It extends the basic concepts of Darwinian evolution to accommodate recent findings and perspectives from the fields of biology, physics, chemistry, and mathematics. The book drives to the heart of the exciting debate on the origins of life and maintenance of order in complex biological systems. It focuses on the concept of self-organization - the first time this concept has been incorporated into evolutionary theory. The book shows how complex systems, contrary to expectations, can spontaneously exhibit stunning degrees of order, and how this order in turn is essential for the emergence and development of life on Earth. Origins of Order will advance our understanding of evolution and provoke considerable discussion among evolutionary, molecular, and developmental biologists.Trade Review. . . an integrative book that will become a landmark and a classic as we grope towards a more comprehensive and satisfying theory of evolution. * Stephen Jay Gould *Stuart Kauffman's book . . . is a global representation of a new field, that will greatly enhance our physical understanding of Nature . . . A superb reading, not limited to physicists and biologists, having most important implications in natural philosophy. * Manfred Eigen *Here is a big book with a big purpose. . . . The Origins of Order is the first book to be written by any of the complexity theorists themselves, and it presents Kauffman's view of the biological realm. . . . The Origins of Order will be seen as a major work in the progression of biological theory. At the very least, Kauffman has made a persuasive case to have his bold hypothesis heard. * Roger Lewin *Table of ContentsPART I: ADAPTATION ON THE EDGE OF CHAOS; PART II: THE CRYSTALLIZATION OF LIFE; PART III: ORDER AND ONTOGENY

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Book SynopsisThis is a simple, but complete, description of synchrotron sources and free electron lasers and of the corresponding instrumentation and techniques. The emphasis is on basic concepts and the mathematical formalism is reduced to a minimum.Trade Review... a useful and refreshing treatment of synchrotron radiation * A.M. Glazer, University of Oxford *... a unique source of information * A. Snigirev, ESRF, Grenoble *... will appeal to all synchrotron radiation users. * D.M. Lawson, Biological Chemistry Dept, John Innes Centre, Norwich *Table of Contents1. Smart tourist guide to a synchrotron light facility ; 2. The Facility ; 3. Applications of synchrotron light ; 4. Free electron lasers (FELs) ; 5. Future directions

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Book SynopsisThe technique of nuclear magnetic resonance (NMR) spectroscopy is an important tool in biochemistry and biophysics for the understanding of the structure and ultimately, the function of biomolecules. This textbook explains the salient features of biological NMR spectroscopy to undergraduates and postgraduates taking courses in NMR, biological NMR, physical biochemistry, and biophysics. Unlike other books in the general field of NMR (except the advanced treatises), the approach here is to introduce and make use of quantum mechanical product operators as well as the classical vector method of explaining the bewildering array of pulse sequences available today. The book covers two- dimensional, three- dimensional, and four- dimensional NMR and their application to protein and DNA structure determination. A unique feature is the coverage of the biological aspects of solid- state NMR spectroscopy. The author provides many selected examples from the research literature, illustrating the applTrade Review... written in a vibrant, enthusiastic style ... It will appeal to a wide readership, from undergraduate chemists ... biochemists and some biologists, to postdoctoral scientists working in this specialized field ... it is good value. * Chemistry in Britain, February 1996 *a very useful book ... I plan on using this book in my course for the foreseeable future and I highly recommend Biomolecular NMR Spectroscopy to you. * Kevin H. Mayo, University of Minnesota Health Sciences Center, Biophysical Journal, Volume 70, June 1996 *The author writes clearly and enthusiastically ... the strength of the book is its broad coverage of scores of applications of NMR to important biological problems ... Another positive aspect of Biomolecular NMR Spectroscopy is the care with which the author places NMR in the context of the larger scientific picture. * Patricia J. Lodi, nature structular biology volume 3 number 5 may 1996 *Table of ContentsPART 1: THEORY ; Introduction ; 1. Methods for spectral assignment - multidimensional NMR ; 2. Obtaining NMR structures ; PART II: PROTEINS ; 3. Protein structure ; 4. Protein folding ; PART III: ENZYMES ; 5. Enzyme function ; 6. Acyl and phosphoryl transfer enzymes ; 7. Other enzymes ; PART IV: NUCLEIC ACIDS AND CARBOHYDRATES ; 8. Nucleic acids and carbohydrates ; PART V: MEMBRANES ; 9. Structure of membranes and membrane proteins ; Appendix 1 Examples of product operator calculations ; Appendix 2 Useful NMR data on amino acid residues ; Appendix 3 Useful NMR data on oligonucleotide residues ; Appendix 4 Useful NMR data on common solvents ; Index

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Book SynopsisThe book describes the importance and impact of a number of elements, other than carbon, in biological chemistry. There is a short background describing the interaction of inorganic molecules, especially metal ions, with biomolecules. The major part of the book contains a survey of biologically important elements and includes briefly the roles played in such varied species as humans, crocodiles, chickens, fish, beetles and plants and in diseases such as cysticfibrosis, methemoglobemia and thalassemia.Trade ReviewWilkins and his wife Pat have produced a readable introduction to the topic of inorganic chemistry in biology. It is bang up to date and is an excellent introduction to the area for students. * Robert W. Hay, Chemistry in Britain, November 1997 *This book illustrates the importance of an interdisciplinary approach to modern science ... The book will provide an excellent basis to a lively approach to the teaching of inorganic chemistry. It is packed with information, but concise, readable, well-illustrated and affordable - I shall recommend it to my undergraduate and graduate students. * Peter J. Sadler, Education in Chemistry, January 1998 *Table of Contents1. The important elements in biology ; 2. The composition of metallobiomolecules ; 3. The examination of the properties of metalloproteins ; 4. Structures and functions ; 5. The s-block ; 6. The d-block-redox chemistry ; 7. The d-block-non-redox chemistry ; 8. The p-block ; Further reading ; Answers to questions

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Book SynopsisWritten by a leading author in the field, Introduction to Protein Science provides a wide-ranging perspective on the study of protein structure and function in the context of bioinformatics and genomics. Opportunities for active learning are provided both in the text and online, enabling students to develop their problem solving skills.Trade ReviewThe third edition of Introduction to Protein Science continues to be a brilliant superior textbook for undergraduate and new postgraduate students in biology and chemistry. * Acta Crystallographica Section D, Volume D72, Part 12 (pp. 1227-1309, 1 December 2016) *It would be difficult to express the qualities of this book better than Doolittle (2005) in his review of the first edition: How can a book with only seven chapters cover so many topics so thoroughly and so well? For one thing, Lesk is a gifted writer with a knack for making complex material eminently understandable. For another, he has managed an adroit balancing of the carefully crafted main text with dozens of well-situated "boxes" and "case studies", each of which provides intriguing connections to the subject at hand. * Acta Crystallographica Section D, Volume D72, Part 12 (pp. 1227-1309, 1 December 2016) *This new edition is, above all, an excellent update of the previous one. * Acta Crystallographica Section D, Volume D72, Part 12 (pp. 1227-1309, 1 December 2016) *Table of Contents1. Introduction ; 2. Protein structure ; 3. Protein structure determination ; 4. Bioinformatics of protein sequence and structure ; 5. Proteins as catalysts: enzyme structure, kinetics, and mechanism ; 6. Proteins with partners ; 7. Evolution of protein structure and function ; 8. Protein folding and design ; 9. Proteomics and systems biology

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Book SynopsisLeaves are among the most abundant organs on earth and are a defining feature of most terrestrial ecosystems. However, a leaf is also a potential meal for a hungry animal and the question therefore arises, why does so much foliage survive in nature? What mechanisms protect leaves so that, on a global scale, only a relatively small proportion of living leaf material is consumed? Leaf survival is in large part due to two processes: firstly, leaf-eating organisms fall prey to predators (top-down pressure on the herbivore); secondly, leaves defend themselves (bottom-up pressure on the herbivore). Remarkably, these two types of event are often linked; they are controlled and coordinated by plants and the molecular mechanisms that underlie this are now beginning to emerge. This novel text focuses exclusively on the leaf, on the herbivorous organisms that attack leaves, and the mechanisms that plants use to defend these vital organs. It begins with an assessment of the scale of herbivory, befTrade ReviewAn essential resource for graduate students and faculty and valuable for upper-division undergraduates. * Choice *Leaf Defence provides an excellent review of the rapidly evolving literature in this field. * Ian T. Baldwin, Nature Review *In a very succinct yet comprehensive format, Farmer explores the remarkably diverse means by which leaves defend themselves against herbivores ... As a guide, Farmer is engaging, authoritative and didactic ... [His] text is an enjoyable read for anyone interested in plant defences with an evolutionary perspective, accessible to a general audience from students studying ecological courses to interested biologists and biochemists. * Maria Jose Endara and Natasha L. Wiggins, Edinburgh Journal of Botany *Leaf Defence ... definitively provides the perfect read for beginners in the field to get up to date and, more importantly, sparks interest that will motivate to follow through with some of the questions. However, it also provides a very helpful overall conceptual framework that integrates and balances the very diverse scientific approaches and views in the field, which will make the volume also valuable to experienced researchers as a guideline and reference. The structure of the book is ingenious in its simplicity and logic. * Andre Kessler, Quarterly Review of Biology *Table of Contents1. Introduction: The leaf and the pressures it faces ; 2. Leaf colour patterning and leaf form ; 3. Structural defences and specialised defence cells ; 4. Chemical defences ; 5. Inducible defences and the jasmonate pathway ; 6. Top-down pressures and indirect defences ; 7. Release and escape from herbivory ; 8. Escape in space : The cliff trees of Socotra

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