Description
Book SynopsisThis book focuses on educating radiologists, radiation oncologists and others interested in imaging research about how to design and conduct clinical trials to evaluate imaging technology and imaging biomarkers.
Table of ContentsContributors, vi
Chapter 1 Imaging technology assessment, 1
Pari V. Pandharipande and G. Scott Gazelle
Chapter 2 Clinical trials of therapy, 10
Sayeh Lavasani, Anthony F. Shields and Ali Mahinbakht
Chapter 3 Clinical trials of image]guided interventions including radiotherapy studies, 29
Gary S. Dorfman and Stephen M. Hahn
Chapter 4 Imaging as a predictor of therapeutic response, 57
David A. Mankoff and Anthony F. Shields
Chapter 5 Screening trials and design, 76
Janie M. Lee, Constance D. Lehman and Diana L. Miglioretti
Chapter 6 Practicalities of running a clinical trial, 91
Michael T. Lu, Elizabeth C. Adami and Udo Hoffmann
Chapter 7 Statistical issues in study design, 103
Nancy A. Obuchowski
Chapter 8 Introduction to biostatistical methods, 126
Diana L. Miglioretti, Todd A. Alonzo and Nancy A. Obuchowski
Chapter 9 Methods for studies of diagnostic tests, 147
Jeffrey D. Blume
Chapter 10 Methods for quantitative imaging biomarker studies, 170
Alicia Y. Toledano and Nancy A. Obuchowski
Chapter 11 Introduction to cost]effectiveness analysis in clinical trials, 189
Ruth C. Carlos and G. Scott Gazelle
Index, 208
