Description
Book SynopsisCompletely revised, updated, and enlarged, this second edition now contains a subchapter on biorecognition assays, plus a chapter on bioprocess control added by the new co-author Jun-ichi Horiuchi, who is one of the leading experts in the field.
The central theme of the textbook remains the application of chemical engineering principles to biological processes in general, demonstrating how a chemical engineer would address and solve problems. To create a logical and clear structure, the book is divided into three parts. The first deals with the basic concepts and principles of chemical engineering and can be read by those students with no prior knowledge of chemical engineering. The second part focuses on process aspects, such as heat and mass transfer, bioreactors, and separation methods. Finally, the third section describes practical aspects, including medical device production, downstream operations, and fermenter engineering. More than 40 exemplary solved exercises facilitate understanding of the complex engineering background, while self-study is supported by the inclusion of over 80 exercises at the end of each chapter, which are supplemented by the corresponding solutions.
An excellent, comprehensive introduction to the principles of biochemical engineering.
Trade Review“I would like to congratulate the authors and publishers for producing such an excellent book. I found it easy to comprehend and well structured. The book has been written with an assumption of minimal prior knowledge of chemical engineering . . .In conclusion, the book constitutes not only a very good starting point for a novice reader but also a comprehensive refresher course for someone who is already familiar with the field.” (Institution of Chemical Engineers, 1 September 2015)
Table of ContentsPreface
Nomenclature
PART I: Basic Concepts and Principles
INTRODUCTION
Background and Scope
Dimensions and Units
Intensive and Extensive Properties
Equilibria and Rates
Batch vs. Continuous Operation
Material Balance
Energy Balance
ELEMENTA OF PHYSICAL TRANSFER PROCESSES
Introduction
Heat Conduction and Molecular Diffusion
Fluid Flow and Momentum Transfer
Laminar vs. Turbulent Flow
Transfer Phenomena in Turbulent Flow
Film Coefficients of Heat and Mass Transfer
CHEMICAL AND BIOCHEMICAL KINETICS
Introduction
Fundamental Reaction Kinetics
CELL KINETICS
Introduction
Cell Growth
Growth Phases in Batch Culture
Factors Affecting Rates of Cell Growth
Cell Growth in Batch Fermentors and Continuous Stirred Tank Fermentor (CSTF)
PART II: Unit Operations and Apparatus for Bio-Systems
HEAT TRANSFER
Introduction
Overall Coefficients U and Film Coefficients h
Mean Temperature Difference
Estimation of Film Coefficients h
Estimation of Overall Coefficients U
MASS TRANSFER
Introduction
Overall Coefficients K and Film Coefficients k of Mass Transfer
Types of Mass Transfer Equipment
Models for Mass Transfer at the Interface
Liquid Phase Mass Transfer with Chemical Reactions
Correlations for Film Coefficients of Mass Transfer
Performance of Packed Column
BIOREACTORS
Introduction
Some Fundamental Concepts
Bubbling Gas-Liquid Reactors
Mechanically Stirred Tanks
Gas Dispersion in Stirred Tanks
Bubble Columns
Airlift Reactors
Packed-Bed Reactors
Microreactors
MEMBRANE PROCESSES
Introduction
Dialysis
Ultrafiltration
Microfiltration
Reverse Osmosis
Membrane Modules
CELL-LIQUID SEPARATION AND CELL DISRUPTION
Introduction
Conventional Filtration
Microfiltration
Centrifugation
Cell Disruption
STERILIZATION
Introduction
Kinetics of Thermal Death of Cells
Batch Heat Sterilization of Culture Media
Continuous Heat Sterilization of Culture Media
Sterilizing Filtration
ADSORPTION AND CHROMATOGRAPHY
Introduction
Equilibria in Adsorption
Rates of Adsorption into Adsorbent Particles
Single- and Multi-Stage Processes for Adsorption
Adsorption in Fixed Beds
Separation by Chromatography
Biorecognition Assay
PART III: Practical Aspects in Bioengineering
FERMENTOR ENGINEERING
Introduction
Stirrer Power Requirements for Non-Newtonian Liquids
Heat Transfer in Fermentors
Gas-Liquid Mass Transfer in Fermentors
Criteria for Scaling-Up Fermentors
Modes of Fermentor Operation
Fermentors for Animal Cell Culture
INSTRUMENTATION AND CONTROL OF BIOPROCESSES
Introduction
Instrumentation of Bioprocesses
Control of Bioprocesses
Advanced Control of Bioprocesses
DOWNSTREAM OPERATIONS IN BIOPROCESSES
Introduction
Separation of Microorganisms by Filtration and Microfiltration
Separation by Chromatography
Separation in Fixed Beds
Sanitation in Downstream Processes
MEDICAL DEVICES
Introduction
Blood and Its Circulation
Oxygenation of Blood
Artificial Kidney
Bioartificial Liver
Appendix
Index
