Search results for ""Author Tony Auffret""
Cranthorpe Millner Publishers Imperfectly Innocent
£10.44
Cranthorpe Millner Publishers Unsavoury Business
Book Synopsis"We lead a quiet life. Talking to people, building up a picture. Like a jigsaw. And just like a jigsaw, we spend a lot of time sorting out pieces of sky. They may seem dull and uninteresting, but we can't leave them out." Is a virus that takes up to eight weeks for symptoms to appear, and kills only 10% of infected people, really the perfect terrorist bioweapon? In this sequel to The Death of a Smoker, four years have passed since Quinton Bickley-Morris, a suspected spy and adversary of the Tufton Street team, slipped out of the country undetected. After a chance sighting, Harry Nevile and his team are desperate to go after him, but the more immediate threat of a suspected terrorist attack on the government takes priority. As Harry's team investigates, piecing together fragments of evidence, the truth is gradually revealed, and it is far closer to home than they could ever have anticipated.
£9.49
Cranthorpe Millner Publishers The Death of a Smoker
Book SynopsisHIGH EXPLOSIVES YOU CAN STOCKPILE, NUCLEAR WEAPONS YOU CAN STOCKPILE, CHEMICAL WARFARE AGENTS YOU CAN STOCKPILE, BIOLOGICAL WEAPONS YOU CAN NOT. The year is 1991, and the Soviet Union is in a state of collapse. But with chaos reigning in Europe and secrets being leaked all too easily from the Ministry of Defence, why should the British Security Services be interested when the premises of a small biotech start-up are burgled, resulting in an accidental death? Complete with suspected Russian spies and biological warfare, this peculiar case proves more complex to solve than anticipated, and truth and trust are tormented by doubt and deception as the path of the small unit of MI5 agents investigating the case is criss-crossed by innocence and subterfuge, bluff and bullying.
£8.54
Royal Society of Chemistry Freezedrying of Pharmaceuticals and
Book SynopsisFreeze-drying, in the past popular in the food industry, has more recently been adopted by the pharmaceutical industry as a standard method for the production of stable solid preparations. Freeze-drying of Pharmaceuticals and Biopharmaceuticals is the first book to specifically describe this process, as related to the pharmaceutical industry. The emphasis of this book is on the properties of the materials processed, how effective formulations are arrived at, and how they are stored and marketed. Beginning with a historical overview of the process, Freeze-drying of Pharmaceuticals and Biopharmaceuticals briefly describes the processes and equipment involved, including: the physics, chemistry and biochemistry associated with freezing, aspects of formulation development, primary and secondary drying; the economics and engineering of scaling up; and, most importantly, attributes of the dried product. It also discusses in detail the science behind freeze-drying, such as the properties of crTable of Contents1: Historical Background; 1.1: Drying as a preservation method; 1.2: The advent of industrial freeze-drying; 1.3: Elements of stability; 1.4: Why Freeze-Dry?; 1.5: Stability - the downside; 2: The Process Sequence in Summary; 2.1: Equipment; 2.2: The drying process - coupled heat and mass transfer; 2.3: How dry is "Dry"?; 2.4: Why not freeze-dry?; 3: Essential Product and Process Parameters; 3.1: General considerations; 3.2: Formulation parameters; 3.3: Process parameters; 3.4: The multidisciplinary nature of freeze-drying; 3.5: Conclusions; 4: Essential Physics of Low Temperature and Freezing; 4.1: Chill versus freezing - undercooling; 4.2: Deep chill - undercooled water; 4.3: Physical properties of undercooled water; 4.4: Ice - nucleation in undercooled water; 4.5: Ice - its crystallisation and crystal habits; 4.6: Nucleation and crystallisation of ice and solutes in aqueous solutions; 4.7: Polymorphic transitions, hydrates and transient hydrates; 4.8: Vitrification as avoidance of crystallisation; 4.9: Freezing in complex biological substrates; 5: Essential Chemistry and Biochemistry associated with low temperature and freezing; 5.1: Physicochemical properties of water-based systems under conditions of deep chill; 5.2: Cold inactivation of proteins; 5.3: Changing phase relationships during freezing; 5.4: Eutectic crystallisation of pH buffer components; 5.5: Effects of freeze concentration on reaction kinetics; 5.6: Complex ternary and multicomponent phase behaviour; 5.7: Supersaturation and vitrification: importance of the state diagram; 5.8: Aqueous glasses as solid solutions; 6: Physical properties of crystalline and amorphous solids; 6.1: Crystalline and amorphous solids - a comparison; 6.2: Non-equilibrium processes in amorphous solids; 6.3: Slow relaxation during cooling and heating; 6.4: The Glass Transition - a summary; 6.5: Amorphous states and freezing behaviour; 6.6: Materials science of the glass transition - its relevance to freeze-drying; 7: Excipients: their role in rational formulation design; 7.1: Definitions and classifications; 7.2: Attributes and requirements; 7.3: Estimation of Tg of complex mixtures; 7.4: Effects of excipients on product attributes; 7.5: Implications for freeze-drying; 7.6: Devitrification of excipients in dried amorphous preparations; 7.7: Pharmaceutical glasses - formulation aspects; 7.8: Constraints; 7.9: Operational degrees of freedom; 8: Primary Drying - the Sublimation of Ice; 8.1: Principles of coupled heat and mass transfer; 8.2: The model; 8.3: Heat transfer mechanisms; 8.4: Influences of formulation and freezing procedure on ice sublimation; 8.5: The interplay of pressure, temperature and time; 8.6: Adjustable parameters: Formulation, concentration and fill depth; 8.7: Ideal conditions; 8.8: Accelerated freeze-drying; 8.9: Monitoring ice sublimation; 8.10: Summary; 9: Secondary Drying; 9.1: Unfrozen (residual) water; 9.2: Removal of unfrozen water by diffusion; 9.3: Effects of pressure; 9.4: Effect of Water Content; 9.5: Effects of fill depth and cake morphology; 9.6: Effect of Temperature; 9.7: Softening and collapse; 9.8: Operational drying protocols - temperature ramping and stepwise heating; 10: Some Practical Aspects - Economics and Engineering; 10.1: Scale up and ICH manufacture; 10.2: Economics; 10.3: Vial closure; packaging; 10.4: Process monitoring and control; 10.5: Stability issues; 11: The Dried Product; 11.1: Physical state: crystalline or amorphous?; 11.2: Essential materials science of crystalline and amorphous products; 11.3: Essentials of thermoanalytical techniques; 11.4: Fragility and its estimation; 11.5: Monitoring physical and chemical stability; 11.6: Estimation of useful shelf life; 11.7: Dynamics in supersaturated solutions; 11.8: Residual water and its estimation; 11.9: Residual water: its influence on stability; 11.10: Unresolved issues; 11.11: Reconstitution at point of use; 12: Case Histories; 12.1: Introduction; 12.2: Choice of formulation; 12.3: Process cycle optimisation; 12.4: Concurrent product and process refinement; 12.5: Inadvertent failures - "unexpected problems"; 12.6: Unfamiliarity with freeze-drying parameters; 12.7: In situ water release during storage; 12.8: Summary and conclusions; 13: Beyond Freeze-drying; 13.1: Alternative water removal technologies; 13.2: Evaporative drying: principles and practice; 13.3: Evaporative drying: the current state; 13.4: Comparisons with freeze-drying; 14: Acknowledgements; 15: Bibliography
£42.75
