Description
Book SynopsisProtein folding and aggregation is the process by which newly synthesized proteins fold into the specific three-dimensional structures defining their biologically active states. It has always been a major focus of research in biochemistry and has often been seen as the unsolved second part of the genetic code. In the last 10 years we have witnessed a quantum leap in the research in this exciting area. Computational methods have improved to the extent of making possible to simulate the complete folding process of small proteins and the early stages of protein aggregation. Experimental methods have evolved to permit resolving fast processes of folding reactions and visualizing single molecules during folding. The findings from these novel experiments and detailed computer simulations have confirmed the main predictions of analytical theory of protein folding. In summary, protein folding research has finally acquired the status of a truly quantitative science, paving the way for more exci
Trade Review"As a whole, the book is strongly focused on current conceptual and theoretical thinking of protein folding.""...it will appeal more to academic scientists involved in fundamental studies." * JACS, Vol 130, No 52, 2008 *
Table of ContentsPreface: Classical Themes and Novel Approaches in Protein Folding and Aggregation; Chapter 1: The Helix as the Simplest Protein Folding Model; Helix-Coil Theory, Stability and Design; Chapter 2: Kinetics and Mechanisms of -Helix Formation; Chapter 3: Protein Folding Theory; The Folding Energy Landscape: A Primer; Chapter 4: Hydrogen Exchange Experiments; Detection and Characterization of Folding Intermediates; Chapter 5: Statistical Differential Scanning Calorimetry; Probing Protein Folding-Unfolding Ensembles; Chapter 6: Fast Protein Folding; Chapter 7: Single Molecule Spectroscopy in Protein Folding; From Ensembles to Single Molecules; Chapter 8: Computer Simulations of Protein Folding; Chapter 9: Protein Design; Tailoring Sequence, Structure and Folding Properties; Chapter 10: Protein Misfolding and -Amyloid Formation; Chapter 11: Computational Studies of Protein Aggregation; Molecular Dynamics Simulations and Bioinformatic Analysis of Scenarios for Protein Aggregation
