Description
Book SynopsisTransient Receptor Potential (TRP) genes were originally identified as encoding critical components of phototransduction in Drosophila. Since the discovery of the first mammalian transient receptor potential channel (TRPC) some eight years ago, more than 20 mammalian homologues have been reported.
Table of ContentsChair's Introduction (J. Putney).
Molecular genetics of Drosophila TRP channels (C. Montell).
Mammalian TRPC channnel subunit assembly (W. Schilling and M. Goel).
TRPC channel interactions with calmodulin and IP3 receptors (M. Zhu & J. Tang).
Plasma membrane localizations of TRPC channels: role of caveolar lipid rafts (I. Ambudkar, et al.).
Assembly and gating of TRPC channels in signalling microdomains (P. Delmas).
General discussion I.
Activation, subunit composition and physiological relevance of DAG-sensitive TRPC proteins (T. Gudermann, et al.).
Signalling mechanisms for TRPC3 channels (J. Putney, et al.).
Diversity of TRP channel activation (B. Nilius and T. Voets).
General discussion II.
Regulation of Drosophila TRP channels by lipid messengers (R. Hardie).
Control of TRPC and store-operated channels by protein kinase C (K. Venkatachalam, et al.).
TRPC4 and TRPC4 deficient mice (M. Freichel, et al.).
TRP channels as drug targets (S. Li, et al.).
Role of TRP channels in oxidative stress (K. Groschner, et al.).
Distribution of TRPC channels in a visceral sensory pathway (M. Buniel, et al.).
Emerging roles of TRPM channels (A. Fleig and R. Penner).
Final discussion.
Index of contributors.
Subject index.
