Description
Book SynopsisWe have all been hypoxic. Fetal tolerance for intrauterine hypoxia arises from evolutionarily conserved physiological mechanisms, the antecedents of which can be learned from diving mammals or species at high altitudes. Understanding fetal hypoxia leads to understanding the huge physiological shifts of neonatal transition and the dangers of perinatal hypoxia.
This comprehensive volume of topical review articles by expert authors addresses the origins of hypoxia tolerance, the impact of oxygen on circulatory transition at birth, and the biochemistry of hypoxia in the pulmonary circuit, as well as the classification, diagnosis, and clinical management of hypoxic respiratory failure and persistent pulmonary hypertension in the term neonate.
The goal of Hypoxic Respiratory Failure in the Newborn is to connect our understanding of hypoxia from animals in extreme environments, with how the human fetus handles its hypoxic environment; and why the human newborn sud
Trade Review
'This book elects to follow the thread of hypoxia, as an originating etiology and defining feature of neonatal pulmonary hypertension. It is a comprehensive and thematic volume of topical articles by world renowned authors, and has assembled all information pertinent to this topic in 38 chapters divided into 5 distinct sections, each marshalled by a dedicated co-editor. This strong interdisciplinary editorial team brings to bear complementary theoretical and practical expertise in different aspects of hypoxia and respiratory failure, and clearly a wide-ranging contact list – the book has over 80 contributing authors. Salient features of this book are helpful signaling pathway diagrams, conceptual illustrations, and synthesis figures by Satyan Lakshminrusimha.
Reading the whole volume provides a satisfying continuous narrative of hypoxia through the evolutionary and developmental timeline, and deeper insight into what might appear to be only a superficial problem solved by turning up the oxygen dial. This book is therefore recommended to practicing clinicians as much as to scholars in this field of science.'
Dr Kurt Stenmark
'It is the most comprehensive discussion of this topic to be found anywhere in the literature. […] There are no comparable texts on this subject, although hypoxia and PPHN are discussed in every standard neonatal textbook. The five authors and the over 80 contributors are the world's research leaders in this topic and are to be congratulated on this superb publication.'
Jay P. Goldsmith, MD (Tulane University School of Medicine), Doody Enterprises
Table of ContentsTable of Contents
1. Introduction
Part 1: The Origins of Hypoxia Tolerance
2. The Human Fetus and Metabolic Adaptations to Hypoxia
3. Hypoxia as a Neuroinflammatory Stimulus During Development
4. Human Adaptations to High Altitude
5. Fetal Llama Adaptation to Altitude in the Andean Altiplano
6. Neonates of Burrowing and Hibernating Mammals: Metabolic and Respiratory Adaptations to Hypoxia
7. Diving Response and Hypoxia in Deep Sea Mammals
8. The Phylogeny and Ontogeny of Cardiorespiratory Coupling in Vertebrates and its Relevance to Non-Invasive Monitoring of the Human Fetus
Part 2: Fetal Hypoxia and Neonatal Transition
9. Fetal and Neonatal Oxygen Environment
10. Fetal Oxygenation During Maternal Hypoxic Illness
11. Hemodynamics of the Circulatory Transition
12. Oxygen During Postnatal Stabilization
Part 3: Biology of Hypoxic Respiratory Failure in the Neonate
13. Hypoxia and Pulmonary Artery Structure
14. Animal Models of PPHN and Vasoconstrictor Signaling in Hypoxia
15. Hypoxia and Endothelial Dysfunction in the Lung
16. Effects of Hypoxia on Pulmonary Vascular Smooth Muscle Contraction and Relaxation
17. Cellular Oxygen Sensing, Mitochondrial Oxygen Sensing and Reactive Oxygen Species
18. Reactive Oxygen Species Signaling in Animal Models of Pulmonary Hypertension
19. Hypoxia, Myocardial Metabolic Adaptation and Right Ventricular Performance
20. Hypoxic Remodeling of Neonatal Pulmonary Artery and Myocardium
21. Hypoxia-Induced Epigenetic Mechanisms of Pulmonary Hypertension
Part 4: Hypoxia and Collateral Damage
22. The Effects of Hypoxia Ischemia on the Term Brain, and A Strategic Approach
23. Effects of Hypoxia on Cerebral Perfusion and the Blood-Brain Barrier
24. Effects of Hypoxia on Airway, Alveolar Function and Respiration
25. Hypoxic Respiratory Failure and the Neonatal Kidney
26. The Effect of Hypoxia on Intestinal Function
27. Effects of Hypoxia on Perinatal Drug Disposition
28. Anesthetic Considerations for the Neonate with Hypoxic Respiratory Failure
Part 5: Diagnosis and Management of Neonatal Hypoxic Respiratory Failure
29. Epidemiology and Outcomes of Infants with Hypoxemic Respiratory Failure
30. Clinical Evaluation of Hypoxic Respiratory Failure
31. Diagnosis of Pulmonary Hypertension by Echocardiography
32. Right Ventricular Performance and Ventricular Interdependence in Hypoxia
33. Ventilation Strategies in Neonatal Hypoxemic Respiratory Failure
34. Pulmonary Hypertension Phenotypes in the Newborn
35. Special Consideration: HRF in Congenital Diaphragmatic Hernia
36. Special Consideration: Hypoxemic Respiratory Failure Among Patients with Hypoxic Ischemic Encephalopathy
37. Special Consideration: HRF in the Preterm
38. Hypoxemic Respiratory Failure – Neonatal Cases
