Description
Book SynopsisThis informative book discusses the latest research on the risk factors and therapeutics in dementia. WHO calls dementia a public health priority. Dementia manifests as a group of symptoms associated with decline in memory or other thinking skills and is severe enough to reduce a person's ability to perform everyday activities. It occurs frequently among elderly people, but it is not necessarily part of the normal aging process. The book has been divided into two broad sections. The first section reviews the risk factors involved in developing dementia, including various medical conditions, lifestyle choices, as well as genetics. The latter section describes various therapeutic interventions in dementia. Although there is no known cure for dementia, this book underlines the current treatment strategies that could momentarily reduce the symptoms and improve the quality of life of the patients. This book highlights the global effort to find better ways to halt the progression of dementia and develop novel therapeutic strategies.
The book would be an interesting read for advanced graduate students and researchers working in the field of neuroscience, genetics, and medicine. It will generate good interest to neurologists, psychiatrists, geriatricians, cardiologists, internal medicine practitioners, epidemiologist, and public health workers.
Table of ContentsRisk Factors
§ Apolipoprotein E (APOE)
§ Histone modifications, demethylation, and microRNA regulation
§ Triggering receptor expressed on myeloid cells 2 (TREM2)
§ Brain-derived neurotrophic factor (BDNF)
§ Bridging integrator 1 (BIN1)
§ Protein tyrosine phosphatase 1B (PTP1B)
§ Leptin signaling
§ Insulin signaling
§ Autophagic dysfunction
§ Ubiquitin-proteasome system dysfunction
§ Circadian dysfunction
§ Endoplasmic Reticulum Stress
§ Depression
§ Normal pressure hydrocephalus
§ Antiphospholipid antibodies
§ Sex hormones
§ Changes in blood factors
§ Infection-induced systemic inflammation
§ Microbiota
§ Abdominal visceral fat
§ Atypical microvascular morphology
§ Plasma exosomes spread
§ Changes in visual cortex
§ Obesity, dyslipidemia, hyperglycemia and hypertension
§ Environmental pollutions
Therapeutic Interventions
§ NMDA receptor antagonists
§ Calcium channel blockers
§ Catecholamine
§ Statins
§ Immunotherapy
§ Quitting smoking
§ Physical activity
§ Diet and nutrition
§ Natural products as promising drug candidates
§ Nanotechnological applications
§ Electroacupuncture
§ Repetitive transcranial magnetic stimulation
§ Transcranial direct current stimulation
§ Reminiscence therapy
§ Reality orientation therapy
§ Bright-light therapy
§ Snoezelen multi-sensory stimulation
§ Behavioral therapy
§ Brain-computer interface applications
§ Music therapy
§ Hypoxic-hyperoxic training
§ Cognitive rehabilitation
§ Cognitive creativity
§ Stem cell research
