Description

Book Synopsis
  • The Current Issues in Medicine series not only highlights current advances but also explores related topics such as translational medicine, regulatory science, neglected diseases, global pandemics, patent law, immunotoxicology, ethics, theranostics, big data, artificial intelligence, novel imaging tools, combination drug products, and novel therapies.
  • Volumes 1 and 2 in this series are focused on current issues in basic medical science, subjects that are fundamental to the practice of medicine. Specifically, volume 1 covers biochemistry, genomics, physiology, and pharmacology.


Table of Contents

Corresponding Authors

Note from the Series Editor

1. Surgical and Medical Specialties: A Journey in Pictures

2. Lymph Nodes—The Neglected Battlefield in Tuberculosis

2.1 Introduction

2.2 Concluding Remarks

2.3 Methods

3. Chronic Kidney Disease in the United States, 2021

Centers for Disease Control and Prevention

3.1 CKD Is Common Among US Adults

3.2 CKD by Age, Sex, and Race/Ethnicity

3.3 CKD Risk Factors

3.4 Ways to Prevent CKD

3.5 Treatment to Lower Blood Pressure

3.6 Testing and Treatment: Find It Early, Treat It Early

3.7 CKD Related Health Problems

3.8 People with CKD Can Lower Their Risk for Kidney Failure

4. Combatting Sepsis: A Public Health Perspective

4.1 National Trends in Sepsis Burden

4.2 Comprehensive Sepsis Prevention Framework

4.3 Building Partnerships and Increasing Awareness

4.4 Future Public Health Opportunities and Challenges

5. Hypertension and Atrial Fibrillation: Closing a Virtuous Circle

6. Cardiovascular Events after Community-Acquired Pneumonia:

A Global Perspective with Systematic Review and Meta-Analysis of

Observational Studies

6.1 Introduction

6.2 Materials and Methods

6.3 Results

6.4 Discussion

6.5 Future Directions

7. Risk Factors for Recurrent Arterial Ischemic Stroke in Children and

Young Adults

7.1 Introduction

7.2 Review Methodology

7.3 Prevalence of AIS Recurrence

7.4 Risk Factors for Recurrent AIS in a Pediatric Population

7.5 Risk Factors for Recurrent AIS in Young Adults

7.6 Secondary Prevention of AIS

7.7 Conclusions

8. Cellular Mechanisms of Human Atherogenesis: Focus on Chronification

of Inflammation and Mitochondrial Mutations

8.1 Introduction

8.2 Cellular Mechanisms of Atherogenesis

8.3 Variants of the Nuclear Genome Associated with Atherosclerosis

8.4 Variants of Mitochondrial Genome Associated with

Atherosclerosis

8.5 Role of Mitochondrial Mutations in Cellular Mechanism of

Atherosclerosis; Chronification of Inflammation

8.6 Conclusions

9. The Microbiota of the Human Gut and Cardiometabolic Health

9.1 Introduction

9.2 The Microbiome

9.3 Major Metabolic Contributors to Microbiome Profile Identity

9.4 Dysbiosis and the Development of T2DM

9.5 Gut Microbiota and CVD

9.6 Concluding Remarks

10. Pharmaceutical Strategies for Reducing LDL-C and Risk of

Cardiovascular Disease

10.1 Introduction

10.2 The Importance of Potency in Statin Monotherapy

10.3 Alternative Strategies to Achieve LDL-C Goal

10.4 PCSK9, a New Therapeutic Target

10.5 Conclusion

11. Atherogenic Markers in Predicting Cardiovascular Risk and Targeting

Residual Cardiovascular Risk

11.1 Introduction

11.2 Markers of Atherogenic Risk

11.3 Residual Cardiovascular Risk

11.4 Conclusions

12. The Continuous Quest for More Effective and Safer

Thromboprophylaxis Protocols

12.1 Thrombosis: A Preventable Healthcare Burden

12.2 Implementation Strategies and Risk Stratification

12.3 Prophylaxis Options with Comparison of Their Efficacy and Risks

12.4 Screening Methods and Secondary Prophylaxis

12.5 New Horizons: Emerging Prophylaxis Methods, Screening

Strategies and Treatment Policies

12.6 Conclusion

13. Wound Healing: Cellular Mechanisms and Pathological Outcomes

13.1 Introduction

13.2 Cellular Aspects of Acute Wound Repair

13.3 When Healing Fails—Factors Influencing Chronic Wound

Healing

13.4 Translational Techniques to Enhance Clinical Understanding of

Wounds

13.5 Current Therapies and Future Opportunities

13.6 Conclusions

14. Advances in Cervical Cancer Prevention: Efficacy, Effectiveness,

Elimination?

14.1 Evolution of Human Papilloma Virus Vaccination

14.2 Prospects for Cervical Cancer Elimination

14.3 Opportunities and Challenges Posed by Resource Levels

14.4 Cervical Screening in the Presence of HPV Vaccination

14.5 Future Perspectives

15. Molecular Classification of Breast Cancer: A Retrospective Cohort

Study

15.1 Introduction

15.2 Materials and Methods

15.3 Results

15.4 Discussion

15.5 Conclusion

16. Cutaneous Squamous Cell Carcinoma: From Biology to Therapy

16.1 Introduction

16.2 Molecular Basis of CSCC

16.3 Treatment of CSCC

16.4 Pharmacologically Induced Cutaneous Squamous Cell Carcinoma

16.5 Conclusions

17. Brain and Testis: More Alike Than Previously Thought?

17.1 Introduction

17.2 Brain and Testis

17.3 Neuron and Sperm

17.4 Concluding Remarks

18. Myomatous Erythrocytosis Syndrome: A Case Series

18.1 Introduction

18.2 Results

18.3 Discussion

18.4 Conclusions

19. Vascular Involvements in Cholangiocarcinoma: Tips and Tricks

19.1 Introduction

19.2 Materials and Methods

19.3 Intrahepatic Cholangiocarcinoma with Vascular Involvement

19.4 Perihilar Cholangiocarcinoma with Vascular Involvement

19.5 Conclusions

20. Rehabilitation for People Living with Dementia: A Practical

Framework of Positive Support

20.1 Why Is Rehabilitation Relevant?

20.2 How Can Cognitive Rehabilitation Benefit People with Dementia

and Carers?

20.3 Where Do Other Nonpharmacological Interventions Fit In?

20.4 How Could Services Adopt a Rehabilitation Model?

20.5 Why Should We Acknowledge the Right to Rehabilitation?

21. Are Dementia with Lewy Bodies and Parkinson’s Disease Dementia

the Same Disease?

21.1 Background

21.2 Conclusions

21.3 Future Perspectives

22. Regenerative Medicine: Could Parkinson’s Be the First

Neurodegenerative Disease to Be Cured?

22.1 Multiplication and Differentiation of NSCs

22.2 Production, Transplantation and Characterization of Precursor

DOP Aminergic Neurons

22.3 Rejection of Transplanted Cells

22.4 From Bench to Bed

22.5 Future Perspective

23. Changes in the Functional Brain Network of Children Undergoing

Repeated Epilepsy Surgery: An EEG Source Connectivity Study

23.1 Introduction

23.2 Materials and Methods

23.3 Results

23.4 Discussion

23.5 Conclusions

24. Blood–Brain Barrier Disruption in Atrial Fibrillation: A Potential

Contributor to the Increased Risk of Dementia and Worsening of

Stroke Outcomes

24.1 Introduction

24.2 The Structure and Function of the Blood–Brain Barrier

24.3 Mechanisms of Blood–Brain Barrier Disruption

24.4 Effects of Altered Cerebral Blood Flow on the Blood–Brain

Barrier

24.5 Disrupted Peripheral and Cerebral Blood Flow in Atrial

Fibrillation

24.6 What Are the Underlying Mechanisms that Increase the Risk

of Stroke and Dementia in Atrial Fibrillation?

24.7 Concluding Remarks

25. Trauma-Induced Coagulopathy: From Pathophysiology to

Outcomes—Overview of an Emerging Medical Problem

25.1 Introduction

25.2 Definition

25.3 Pathophysiology

25.4 Specials Clinical Forms of TIC

25.5 Diagnosis

25.6 Outcomes

25.7 Hints for Therapy

25.8 Management of Patients with Severe Trauma in an ER

26. Advances in Fractures and Dislocations of the Hip Joint

26.1 Hip Fractures

26.2 Traumatic Dislocations of the Hip Joint

27. Predicting Scoliosis Progression: A Challenge for Researchers and

Clinicians

28. Prosthetic and Mechanical Parameters of the Facial Bone under the

Load of Different Dental Implant Shapes: A Parametric Study

28.1 Introduction

28.2 Results

28.3 Discussion

28.4 Materials and Methods

28.5 Conclusions

29. Circulating Arsenic Is Associated with Long-Term Risk of Graft Failure

in Kidney Transplant Recipients: A Prospective Cohort Study

29.1 Introduction

29.2 Methods

29.3 Results

29.4 Discussion

29.5 Conclusions

30. Successful Aging and Chronic Osteoarthritis

Ray Marks, EdD

30.1 Introduction

30.2 Methods

30.3 Results

30.4 Discussion

30.5 Conclusions

30.6 Future Research and Practical Challenges

31. Radiographic Analysis on the Distortion of the Anatomy of First

Metatarsal Head in Dorsoplantar Projection

31.1 Introduction

31.2 Material and Methods

31.3 Results

31.4 Discussion

31.5 Conclusions

32. Clinical Aspects and Current Therapeutic Approaches for Fibrodysplasia

Ossificans Progressiva

32.1 Introduction

32.2 Epidemiology

32.3 Pathophysiology

32.4 Natural Clinical Course

32.5 Skeletal Malformations

32.6 Managements and Treatments

32.7 On-Going Clinical Trials for FOP

32.8 Conclusions

33. Comparison and Lessons Learned from Neglected Tropical Diseases

and Tuberculosis

33.1 Introduction

33.2 Underlying Burden of Disease

33.3 Influence of Poverty and Development

33.4 Neglect

33.5 Conclusions

34. Current Issues in Antibiotic Antimicrobial Resistance

Centers for Disease Control and Prevention

34.1 About Antibiotic Resistance

34.2 Antibiotic Resistance Threatens Everyone

34.3 Brief History of Resistance and Antibiotics

34.4 Fighting Antibiotic Resistance

34.5 Antibiotic Resistance: 5 Things to Know

34.6 Antibiotic-Resistant Infections Threaten Modern Medicine

34.7 Examples of How Antibiotic Resistance Affects Humans, Animals

and the Environment

34.8 How Antibiotic Resistance Moves Directly Germ to Germ

34.9 Protect People and Animals, Combat Antibiotic Resistance:

Actions for Livestock and Poultry Producers

35. Ending AIDS as a Public Health Threat by 2030: Time to Reset Targets

for 2025

35.1 Introduction

35.2 The Process and Structures

35.3 Addressing the Key Challenges, Concerns, and Priorities

35.4 Conclusions

36. 9 Questions to Help Make Sense of Health Research

National Institutes of Health

37. Transdisciplinary Research and Clinical Priorities for Better Health

37.1 Lifestyle and Prevention of Chronic Diseases

37.2 Intergenerational and Life Course Consequences of

Preconception and in utero Health

37.3 Ecological Footprint of Modern Medical Systems

37.4 Intensive Animal Farming and Pollution

37.5 Benefits of Investing in Preventive Science, Education,

and Medicine

37.6 Conclusions and Future Directions

38. Current Issues about Health News Stories

National Institutes of Health

38.1 When Clinical Research is in the News

38.2 Health Approaches in the News

38.3 Information Missing from Health Stories

38.4 What’s Missing: Important Details!

38.5 What’s Missing: Information on Side Effects!

38.6 What’s Missing: The Full Story!

38.7 What’s Missing: Humans!

38.8 Conflicting Health News

38.9 Accuracy in the Media

38.10 What the Media Says about Complementary Health Approaches

38.11 Is It Real Online News? Or Just Advertising?

38.12 Checklist for Understanding Health News Stories

38.13 Remember…

38.14 Supplementary Information

39. Complementary, Alternative, or Integrative Health: What’s in

a Name?

National Institutes of Health

39.1 Complementary versus Alternative

39.2 Integrative Health

39.3 Complementary Health Approaches

40. Current Issues in Complementary and Integrative Health

National Institutes of Health

40.1 4 Things to Know about Dietary Supplements for Eye Conditions

40.2 5 Things to Know about Omega-3s for Heart Disease

40.3 6 Tips: How Herbs Can Interact with Medicines

40.4 7 Tips: What You Need to Know about Natural Products for

Musculoskeletal Inflammation

40.5 6 Things You Should Know: The Science of Chronic Pain and

Complementary Health Practices

40.6 4 Tips: Mind and Body Practices for Common Aging-Related

Conditions

40.7 6 Things You Need to Know about Cancer and Complementary

Health Approaches

40.8 5 Things to Know about Complementary Health Practices for

Cognitive Function, Dementia, and Alzheimer’s Disease

40.9 4 Tips: Asthma and Complementary Health Practices

40.10 10 Things to Know about the Science of Health

40.11 5 Things to Know about Relaxation Techniques for Stress

40.12 7 Things to Know about Complementary Approaches for

Fibromyalgia

40.13 5 Tips: Natural Products for the Flu and Colds: What Does the

Science Say?

40.14 5 Things You Should Know about Yoga

40.15 5 Things to Know about Chronic Low-Back Pain and

Complementary Health Practices

40.16 4 Things to Know about Spinal Manipulation for Low-Back Pain

40.17 7 Things to Know about Complementary Health Approaches for

Autism Spectrum Disorder

40.18 4 Tips: Start Talking with Your Health Care Providers about

Complementary Health Approaches

40.19 7 Things to Know about Omega-3 Fatty Acids

40.20 5 Tips: Natural Products Used for Common Aging-Related

Conditions

40.21 6 Things You Should Know about Dietary Supplements for

Osteoarthritis

40.22 7 Tips: Know the Facts about Supplements Marketed for Weight

Loss

40.23 5 Things to Know about Sleep Disorders and Complementary

Health Approaches

40.24 6 Things to Know about Complementary Health Approaches for

Seasonal Affective Disorder

40.25 5 Tips: What Consumers Need to Know about Dietary Supplements

40.26 5 Things to Know about St. John’s Wort and Depression

40.27 6 Things to Know about Massage Therapy for Health Purposes

40.28 7 Things to Know about Complementary Health Approaches for

ADHD

40.29 6 Things to Know about Type 2 Diabetes and Dietary Supplements

40.30 5 Tips: What You Should Know about Complementary Health

Approaches for BPH

40.31 8 Things to Know about Mind and Body Approaches for Health

Problems Facing Military Personnel and Veterans

40.32 5 Tips: What You Should Know about Tai Chi for Health

40.33 6 Things to Know about Complementary Health Approaches for

Seasonal Allergy Relief

40.34 7 Tips: What You Should Know about Complementary Health

Approaches for Multiple Sclerosis

40.35 7 Things to Know about Complementary Health Approaches for

Anxiety

40.36 6 Tips: What You Need to Know about Complementary Health

Approaches for Skin Conditions

40.37 5 Things to Know about Complementary Health Approaches for

Parkinson’s Disease

40.38 5 Myths about Popular Natural Products Marketed for Disease

Prevention and Wellness

40.39 7 Things to Know about Mind and Body Practices for Children

and Teens

40.40 6 Things to Know about Travel-Related Ailments and

Complementary Health Approaches

40.41 6 Tips: IBS and Complementary Health Practices

40.42 5 Things You Should Know about Dietary Supplements for

Hepatitis C

40.43 5 Things to Know about Probiotics

40.44 5 Things to Know about Mind and Body Approaches for

Substance Use Disorders

40.45 4 Things to Know about Menopausal Symptoms and

Complementary Health Practices

40.46 6 Things to Know When Selecting a Complementary Health

Practitioner

40.47 5 Tips: What You Should Know about Popular Herbs

40.48 8 Things to Know about Meditation for Health

40.49 6 Things to Know about Complementary Health Approaches for

Quitting Smoking

40.50 5 Tips: What You Should Know about High Blood Cholesterol

40.51 8 Things to Know about Depression and Complementary Health

Approaches

40.52 10 Things to Know about Dietary Supplements for Children and

Teens

40.53 4 Things To Know About Menopausal Symptoms and

Complementary Health Practices

40.54 Ayurvedic Medicine: In Depth

40.55 Terms Related to Complementary and Integrative Health

41. Skin Conditions and Complementary Health Approaches: What the

Science Says

National Institutes of Health

41.1 Atopic Dermatitis

41.2 Psoriasis

41.3 Acne

41.4 Impetigo

41.5 Rosacea

42. Nutrition and Health across the Lifespan: Guidelines and

Recommendations

U.S. Department of Agriculture

42.1 Guideline 1: Follow a Healthy Dietary Pattern at Every Life Stage

42.2 Guideline 2: Customize and Enjoy Food and Beverage Choices

to Reflect Personal Preferences, Cultural Traditions, and

Budgetary Considerations

42.3 Guideline 3: Focus on Meeting Food Group Needs With

Nutrient-Dense Foods and Beverages, and Stay Within Calorie

Limits

42.4 Guideline 4: Limit Foods and Beverages Higher in Added Sugars,

Saturated Fat, and Sodium, and Limit Alcoholic Beverages

42.5 Support Healthy Dietary Patterns for All Americans

43. Using Dietary Supplements Wisely

National Institutes of Health

43.1 What’s the Bottom Line?

43.2 What Are Dietary Supplements?

43.3 What Are Herbal Supplements?

43.4 Dietary Supplement Use in the United States

43.5 Federal Regulation of Dietary Supplements

43.6 What the Science Says about the Effectiveness of Dietary

Supplements

43.7 What the Science Says about the Safety and Side Effects of

Dietary Supplements

43.8 Safety Considerations

44. Association of Genetic Liability to Smoking Initiation with e-Cigarette

Use in Young Adults: A Cohort Study

44.1 Introduction

44.2 Results

44.3 Discussion

45. Current Issues in Vaccine Development

45.1 Vaccine Development: An Introductory Overview

45.2 How Vaccines Work

45.3 Vaccine Development

45.4 Improving Vaccine R&D

45.5 Technologies and Approaches for Vaccine R&D

45.6 Addressing Challenges Related to Vaccine R&D: Policy Options

45.7 Technologies and Approaches That May Enhance Vaccine Testing

45.8 Challenges Related to Vaccine Testing: Policy Options

45.9 Technologies and Approaches for Vaccine Manufacturing

45.10 Challenges Related to Vaccine Manufacturing: Policy Options

45.11 Vaccine Development: Economics and Role of Incentives

45.12 Economic Challenges to Vaccine Development: Policy Options

46. Cannabis Products Containing Delta-8 Tetrahydrocannabinol:

Increased Availability and Reports of Adverse Events

Centers for Disease Control and Prevention

46.1 Introduction

46.2 Background

46.3 Recommendations for the Public and Consumers

46.4 Recommendations for Public Health Departments and Poison

Control Centers, Including Those in Locations Where Laws Only

Permit Hemp Marketplaces

46.5 Recommendations for Retailers Selling Cannabis Products 1013

46.6 Recommendations for Healthcare Providers

46.7 For More Information

47. Natural Doesn’t Necessarily Mean Safer, or Better

National Institutes of Health

48. How Medications and Supplements Can Interact

National Institutes of Health

48.1 Test Your Knowledge: Are These Statements True or False?

48.2 Talk With Your Health Care Providers

48.3 Some Supplements May Increase the Effects—and Side

Effects—of Drugs

48.4 Some Supplements May Decrease the Effects of Drugs

48.5 More about St. John’s Wort

48.6 Interactions with Over-the-Counter Drugs

48.7 When Drug-Supplement Interactions Are Especially Important

48.8 Drugs with a Narrow Therapeutic Range

48.9 If You’re Going to Have Surgery

48.10 Tips on Reading Supplement Labels

48.11 Here’s a Hint for Your Next Visit to a Health Care Provider

49. Antioxidants: Current Issues and Future Trends

National Institutes of Health

49.1 Introduction

49.2 Key Points

49.3 About Free Radicals, Oxidative Stress, and Antioxidants

49.4 Use of Antioxidant Supplements in the United States

49.5 Safety

49.6 What the Science Says

49.7 If You Are Considering Antioxidant Supplements

49.8 NCCIH- and NIH-Funded Research

49.9 For More Information

50. Hearing Loss and Hearing Aids: Current Issues

50.1 What Is Hearing Loss?

50.2 What Noises Cause Hearing Loss?

50.3 How Does Loud Noise Cause Hearing Loss?

50.4 What Is Noise-Induced Hearing Loss?

50.5 How Can I Tell If I Have a Hearing Problem?

50.6 Who Can I Turn to for Help with My Hearing Loss?

50.7 Why Am I Losing My Hearing?

50.8 What Is an Audiogram?

50.9 What Treatments and Devices Can Help?

50.10 Hearing Aids: More Details

50.11 What Are Some Features for Hearing Aids?

50.12 Hearing Aids and How They Work

50.13 Are There Different Styles of Hearing Aids?

50.14 Are New Types of Aids Available?

50.15 What Is the Difference between Analog and Digital Hearing Aids?

50.16 Which Hearing Aid Will Work Best for Me?

50.17 How Do I Get a Hearing Evaluation before Getting Hearing Aids?

50.18 What Is the Difference between Prescription and Over-the

Counter Hearing Aids?

50.19 Who Are OTC Hearing Aids for?

50.20 What Questions Should I Ask before Buying a Hearing Aid?

50.21 How Can I Adjust to My Hearing Aid?

50.22 How Can I Care for My Hearing Aid? 1075

50.23 Can I Obtain Financial Assistance for a Hearing Aid?

50.24 Hearing Aids vs. Personal Sound Amplification Products

51. Bacterial Evolution during Human Infection: Adapt and Live or Adapt

and Die

51.1 Introduction

51.2 Conclusions

52. Roadblocks in Chagas Disease Care in Endemic and Nonendemic

Countries: Argentina, Colombia, Spain, and the United States.

The NET-Heart Project

52.1 Introduction

52.2 Methods

52.3 Results

52.4 Discussion

52.5 Conclusions

53. Pathogens Infecting the Central Nervous System

54. Current Issues in Vaccines

Centers for Disease Control and Prevention

54.1 History of Vaccines

54.2 Common Ingredients in U.S. Licensed Vaccines

54.3 Understanding the Vaccine Adverse Event Reporting System

54.4 Science Summary: CDC Studies on Thimerosal in Vaccines

54.5 Pregnancy and Vaccination

54.6 Understanding Thimerosal, Mercury, and Vaccine Safety

54.7 2022 Recommended Immunizations for Children from Birth

through 6 Years Old

54.8 2022 Recommended Immunizations for Children 7–18 Years

54.9 Recommended Adult Immunization Schedule for Ages 19 Years

or Older

55. What Are Embryonic Stem Cells and How Can They Help Us?

55.1 It All Begins in Fertilization, When the Sperm Meets the Egg

55.2 Cloning

55.3 Therapeutic Cloning

55.4 Reprogramming

55.5 Therapy?

55.6 Addendum by the Series Editor, Dr. Raj Bawa: The Future of

Embryonic Stem Cells

56. The Rise and Rise of Mitochondrial DNA Mutations

56.1 Evolutionary Aspects of Mitochondrial Genetics

56.2 Clonal Expansion of mtDNA Mutations

56.3 Population Dynamics of mtDNA Point Mutations

56.4 Population Dynamics of mtDNA Deletions

56.5 Important Challenges and Unanswered Questions

56.6 Modelling Clonal Expansion

56.7 Conclusion and Future Perspectives

57. Hallmarks of Cancer—the New Testament

57.1 A Historical Perspective on Cancer

57.2 Hallmarks of Cancer

57.3 New Hallmark 1: Dedifferentiation and Transdifferentiation

57.4 New Hallmark 2: Epigenetic Dysregulation

57.5 New Hallmark 3: Altered Microbiome

57.6 New Hallmark 4: Altered Neuronal Signalling

57.7 Conclusion

58. Adipose Tissue in Health and Disease

58.1 Introduction

58.2 Adipose Tissue Expansion and Development

58.3 Inflammation

58.4 Location of Lipid Storage

58.5 Adipose Tissue Lipolysis and Insulin Resistance

58.6 Endocrine Functions within Adipose Tissue

58.7 Emerging Approaches to Combat Adipose Tissue-Derived

Metabolic Dysfunction

58.8 Concluding Remarks

59. Viral Pathogenesis of SARS-CoV-2 Infection and Male Reproductive

Health

59.1 Introduction

59.2 SARS-CoV-2: History, Origin and Transmission

59.3 Possible Mechanism of SARS-CoV-2 Invasion into Host Cells and

Immune Pattern of Infection

59.4 Effect on the Male Reproductive System

59.5 SARS-CoV-2 and Male Fertility

59.6 Gender-Based Susceptibility

59.7 Conclusion

59.8 Future Perspectives

60. Elevated CO2 Modulates Airway Contractility

60.1 Introduction

60.2 Hypercapnia-Induced Bronchoconstriction

60.3 Respiratory Acidosis-Related Bronchodilation

60.4 Effect of Hypocapnia on Airway Contractility

60.5 Conclusion

Index

Advances in Surgical and Medical Specialties

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      Publisher: Jenny Stanford Publishing
      Publication Date: 14/07/2023
      ISBN13: 9789814877459, 978-9814877459
      ISBN10: 981487745X
      Also in:
      Surgery

      Description

      Book Synopsis
      • The Current Issues in Medicine series not only highlights current advances but also explores related topics such as translational medicine, regulatory science, neglected diseases, global pandemics, patent law, immunotoxicology, ethics, theranostics, big data, artificial intelligence, novel imaging tools, combination drug products, and novel therapies.
      • Volumes 1 and 2 in this series are focused on current issues in basic medical science, subjects that are fundamental to the practice of medicine. Specifically, volume 1 covers biochemistry, genomics, physiology, and pharmacology.


      Table of Contents

      Corresponding Authors

      Note from the Series Editor

      1. Surgical and Medical Specialties: A Journey in Pictures

      2. Lymph Nodes—The Neglected Battlefield in Tuberculosis

      2.1 Introduction

      2.2 Concluding Remarks

      2.3 Methods

      3. Chronic Kidney Disease in the United States, 2021

      Centers for Disease Control and Prevention

      3.1 CKD Is Common Among US Adults

      3.2 CKD by Age, Sex, and Race/Ethnicity

      3.3 CKD Risk Factors

      3.4 Ways to Prevent CKD

      3.5 Treatment to Lower Blood Pressure

      3.6 Testing and Treatment: Find It Early, Treat It Early

      3.7 CKD Related Health Problems

      3.8 People with CKD Can Lower Their Risk for Kidney Failure

      4. Combatting Sepsis: A Public Health Perspective

      4.1 National Trends in Sepsis Burden

      4.2 Comprehensive Sepsis Prevention Framework

      4.3 Building Partnerships and Increasing Awareness

      4.4 Future Public Health Opportunities and Challenges

      5. Hypertension and Atrial Fibrillation: Closing a Virtuous Circle

      6. Cardiovascular Events after Community-Acquired Pneumonia:

      A Global Perspective with Systematic Review and Meta-Analysis of

      Observational Studies

      6.1 Introduction

      6.2 Materials and Methods

      6.3 Results

      6.4 Discussion

      6.5 Future Directions

      7. Risk Factors for Recurrent Arterial Ischemic Stroke in Children and

      Young Adults

      7.1 Introduction

      7.2 Review Methodology

      7.3 Prevalence of AIS Recurrence

      7.4 Risk Factors for Recurrent AIS in a Pediatric Population

      7.5 Risk Factors for Recurrent AIS in Young Adults

      7.6 Secondary Prevention of AIS

      7.7 Conclusions

      8. Cellular Mechanisms of Human Atherogenesis: Focus on Chronification

      of Inflammation and Mitochondrial Mutations

      8.1 Introduction

      8.2 Cellular Mechanisms of Atherogenesis

      8.3 Variants of the Nuclear Genome Associated with Atherosclerosis

      8.4 Variants of Mitochondrial Genome Associated with

      Atherosclerosis

      8.5 Role of Mitochondrial Mutations in Cellular Mechanism of

      Atherosclerosis; Chronification of Inflammation

      8.6 Conclusions

      9. The Microbiota of the Human Gut and Cardiometabolic Health

      9.1 Introduction

      9.2 The Microbiome

      9.3 Major Metabolic Contributors to Microbiome Profile Identity

      9.4 Dysbiosis and the Development of T2DM

      9.5 Gut Microbiota and CVD

      9.6 Concluding Remarks

      10. Pharmaceutical Strategies for Reducing LDL-C and Risk of

      Cardiovascular Disease

      10.1 Introduction

      10.2 The Importance of Potency in Statin Monotherapy

      10.3 Alternative Strategies to Achieve LDL-C Goal

      10.4 PCSK9, a New Therapeutic Target

      10.5 Conclusion

      11. Atherogenic Markers in Predicting Cardiovascular Risk and Targeting

      Residual Cardiovascular Risk

      11.1 Introduction

      11.2 Markers of Atherogenic Risk

      11.3 Residual Cardiovascular Risk

      11.4 Conclusions

      12. The Continuous Quest for More Effective and Safer

      Thromboprophylaxis Protocols

      12.1 Thrombosis: A Preventable Healthcare Burden

      12.2 Implementation Strategies and Risk Stratification

      12.3 Prophylaxis Options with Comparison of Their Efficacy and Risks

      12.4 Screening Methods and Secondary Prophylaxis

      12.5 New Horizons: Emerging Prophylaxis Methods, Screening

      Strategies and Treatment Policies

      12.6 Conclusion

      13. Wound Healing: Cellular Mechanisms and Pathological Outcomes

      13.1 Introduction

      13.2 Cellular Aspects of Acute Wound Repair

      13.3 When Healing Fails—Factors Influencing Chronic Wound

      Healing

      13.4 Translational Techniques to Enhance Clinical Understanding of

      Wounds

      13.5 Current Therapies and Future Opportunities

      13.6 Conclusions

      14. Advances in Cervical Cancer Prevention: Efficacy, Effectiveness,

      Elimination?

      14.1 Evolution of Human Papilloma Virus Vaccination

      14.2 Prospects for Cervical Cancer Elimination

      14.3 Opportunities and Challenges Posed by Resource Levels

      14.4 Cervical Screening in the Presence of HPV Vaccination

      14.5 Future Perspectives

      15. Molecular Classification of Breast Cancer: A Retrospective Cohort

      Study

      15.1 Introduction

      15.2 Materials and Methods

      15.3 Results

      15.4 Discussion

      15.5 Conclusion

      16. Cutaneous Squamous Cell Carcinoma: From Biology to Therapy

      16.1 Introduction

      16.2 Molecular Basis of CSCC

      16.3 Treatment of CSCC

      16.4 Pharmacologically Induced Cutaneous Squamous Cell Carcinoma

      16.5 Conclusions

      17. Brain and Testis: More Alike Than Previously Thought?

      17.1 Introduction

      17.2 Brain and Testis

      17.3 Neuron and Sperm

      17.4 Concluding Remarks

      18. Myomatous Erythrocytosis Syndrome: A Case Series

      18.1 Introduction

      18.2 Results

      18.3 Discussion

      18.4 Conclusions

      19. Vascular Involvements in Cholangiocarcinoma: Tips and Tricks

      19.1 Introduction

      19.2 Materials and Methods

      19.3 Intrahepatic Cholangiocarcinoma with Vascular Involvement

      19.4 Perihilar Cholangiocarcinoma with Vascular Involvement

      19.5 Conclusions

      20. Rehabilitation for People Living with Dementia: A Practical

      Framework of Positive Support

      20.1 Why Is Rehabilitation Relevant?

      20.2 How Can Cognitive Rehabilitation Benefit People with Dementia

      and Carers?

      20.3 Where Do Other Nonpharmacological Interventions Fit In?

      20.4 How Could Services Adopt a Rehabilitation Model?

      20.5 Why Should We Acknowledge the Right to Rehabilitation?

      21. Are Dementia with Lewy Bodies and Parkinson’s Disease Dementia

      the Same Disease?

      21.1 Background

      21.2 Conclusions

      21.3 Future Perspectives

      22. Regenerative Medicine: Could Parkinson’s Be the First

      Neurodegenerative Disease to Be Cured?

      22.1 Multiplication and Differentiation of NSCs

      22.2 Production, Transplantation and Characterization of Precursor

      DOP Aminergic Neurons

      22.3 Rejection of Transplanted Cells

      22.4 From Bench to Bed

      22.5 Future Perspective

      23. Changes in the Functional Brain Network of Children Undergoing

      Repeated Epilepsy Surgery: An EEG Source Connectivity Study

      23.1 Introduction

      23.2 Materials and Methods

      23.3 Results

      23.4 Discussion

      23.5 Conclusions

      24. Blood–Brain Barrier Disruption in Atrial Fibrillation: A Potential

      Contributor to the Increased Risk of Dementia and Worsening of

      Stroke Outcomes

      24.1 Introduction

      24.2 The Structure and Function of the Blood–Brain Barrier

      24.3 Mechanisms of Blood–Brain Barrier Disruption

      24.4 Effects of Altered Cerebral Blood Flow on the Blood–Brain

      Barrier

      24.5 Disrupted Peripheral and Cerebral Blood Flow in Atrial

      Fibrillation

      24.6 What Are the Underlying Mechanisms that Increase the Risk

      of Stroke and Dementia in Atrial Fibrillation?

      24.7 Concluding Remarks

      25. Trauma-Induced Coagulopathy: From Pathophysiology to

      Outcomes—Overview of an Emerging Medical Problem

      25.1 Introduction

      25.2 Definition

      25.3 Pathophysiology

      25.4 Specials Clinical Forms of TIC

      25.5 Diagnosis

      25.6 Outcomes

      25.7 Hints for Therapy

      25.8 Management of Patients with Severe Trauma in an ER

      26. Advances in Fractures and Dislocations of the Hip Joint

      26.1 Hip Fractures

      26.2 Traumatic Dislocations of the Hip Joint

      27. Predicting Scoliosis Progression: A Challenge for Researchers and

      Clinicians

      28. Prosthetic and Mechanical Parameters of the Facial Bone under the

      Load of Different Dental Implant Shapes: A Parametric Study

      28.1 Introduction

      28.2 Results

      28.3 Discussion

      28.4 Materials and Methods

      28.5 Conclusions

      29. Circulating Arsenic Is Associated with Long-Term Risk of Graft Failure

      in Kidney Transplant Recipients: A Prospective Cohort Study

      29.1 Introduction

      29.2 Methods

      29.3 Results

      29.4 Discussion

      29.5 Conclusions

      30. Successful Aging and Chronic Osteoarthritis

      Ray Marks, EdD

      30.1 Introduction

      30.2 Methods

      30.3 Results

      30.4 Discussion

      30.5 Conclusions

      30.6 Future Research and Practical Challenges

      31. Radiographic Analysis on the Distortion of the Anatomy of First

      Metatarsal Head in Dorsoplantar Projection

      31.1 Introduction

      31.2 Material and Methods

      31.3 Results

      31.4 Discussion

      31.5 Conclusions

      32. Clinical Aspects and Current Therapeutic Approaches for Fibrodysplasia

      Ossificans Progressiva

      32.1 Introduction

      32.2 Epidemiology

      32.3 Pathophysiology

      32.4 Natural Clinical Course

      32.5 Skeletal Malformations

      32.6 Managements and Treatments

      32.7 On-Going Clinical Trials for FOP

      32.8 Conclusions

      33. Comparison and Lessons Learned from Neglected Tropical Diseases

      and Tuberculosis

      33.1 Introduction

      33.2 Underlying Burden of Disease

      33.3 Influence of Poverty and Development

      33.4 Neglect

      33.5 Conclusions

      34. Current Issues in Antibiotic Antimicrobial Resistance

      Centers for Disease Control and Prevention

      34.1 About Antibiotic Resistance

      34.2 Antibiotic Resistance Threatens Everyone

      34.3 Brief History of Resistance and Antibiotics

      34.4 Fighting Antibiotic Resistance

      34.5 Antibiotic Resistance: 5 Things to Know

      34.6 Antibiotic-Resistant Infections Threaten Modern Medicine

      34.7 Examples of How Antibiotic Resistance Affects Humans, Animals

      and the Environment

      34.8 How Antibiotic Resistance Moves Directly Germ to Germ

      34.9 Protect People and Animals, Combat Antibiotic Resistance:

      Actions for Livestock and Poultry Producers

      35. Ending AIDS as a Public Health Threat by 2030: Time to Reset Targets

      for 2025

      35.1 Introduction

      35.2 The Process and Structures

      35.3 Addressing the Key Challenges, Concerns, and Priorities

      35.4 Conclusions

      36. 9 Questions to Help Make Sense of Health Research

      National Institutes of Health

      37. Transdisciplinary Research and Clinical Priorities for Better Health

      37.1 Lifestyle and Prevention of Chronic Diseases

      37.2 Intergenerational and Life Course Consequences of

      Preconception and in utero Health

      37.3 Ecological Footprint of Modern Medical Systems

      37.4 Intensive Animal Farming and Pollution

      37.5 Benefits of Investing in Preventive Science, Education,

      and Medicine

      37.6 Conclusions and Future Directions

      38. Current Issues about Health News Stories

      National Institutes of Health

      38.1 When Clinical Research is in the News

      38.2 Health Approaches in the News

      38.3 Information Missing from Health Stories

      38.4 What’s Missing: Important Details!

      38.5 What’s Missing: Information on Side Effects!

      38.6 What’s Missing: The Full Story!

      38.7 What’s Missing: Humans!

      38.8 Conflicting Health News

      38.9 Accuracy in the Media

      38.10 What the Media Says about Complementary Health Approaches

      38.11 Is It Real Online News? Or Just Advertising?

      38.12 Checklist for Understanding Health News Stories

      38.13 Remember…

      38.14 Supplementary Information

      39. Complementary, Alternative, or Integrative Health: What’s in

      a Name?

      National Institutes of Health

      39.1 Complementary versus Alternative

      39.2 Integrative Health

      39.3 Complementary Health Approaches

      40. Current Issues in Complementary and Integrative Health

      National Institutes of Health

      40.1 4 Things to Know about Dietary Supplements for Eye Conditions

      40.2 5 Things to Know about Omega-3s for Heart Disease

      40.3 6 Tips: How Herbs Can Interact with Medicines

      40.4 7 Tips: What You Need to Know about Natural Products for

      Musculoskeletal Inflammation

      40.5 6 Things You Should Know: The Science of Chronic Pain and

      Complementary Health Practices

      40.6 4 Tips: Mind and Body Practices for Common Aging-Related

      Conditions

      40.7 6 Things You Need to Know about Cancer and Complementary

      Health Approaches

      40.8 5 Things to Know about Complementary Health Practices for

      Cognitive Function, Dementia, and Alzheimer’s Disease

      40.9 4 Tips: Asthma and Complementary Health Practices

      40.10 10 Things to Know about the Science of Health

      40.11 5 Things to Know about Relaxation Techniques for Stress

      40.12 7 Things to Know about Complementary Approaches for

      Fibromyalgia

      40.13 5 Tips: Natural Products for the Flu and Colds: What Does the

      Science Say?

      40.14 5 Things You Should Know about Yoga

      40.15 5 Things to Know about Chronic Low-Back Pain and

      Complementary Health Practices

      40.16 4 Things to Know about Spinal Manipulation for Low-Back Pain

      40.17 7 Things to Know about Complementary Health Approaches for

      Autism Spectrum Disorder

      40.18 4 Tips: Start Talking with Your Health Care Providers about

      Complementary Health Approaches

      40.19 7 Things to Know about Omega-3 Fatty Acids

      40.20 5 Tips: Natural Products Used for Common Aging-Related

      Conditions

      40.21 6 Things You Should Know about Dietary Supplements for

      Osteoarthritis

      40.22 7 Tips: Know the Facts about Supplements Marketed for Weight

      Loss

      40.23 5 Things to Know about Sleep Disorders and Complementary

      Health Approaches

      40.24 6 Things to Know about Complementary Health Approaches for

      Seasonal Affective Disorder

      40.25 5 Tips: What Consumers Need to Know about Dietary Supplements

      40.26 5 Things to Know about St. John’s Wort and Depression

      40.27 6 Things to Know about Massage Therapy for Health Purposes

      40.28 7 Things to Know about Complementary Health Approaches for

      ADHD

      40.29 6 Things to Know about Type 2 Diabetes and Dietary Supplements

      40.30 5 Tips: What You Should Know about Complementary Health

      Approaches for BPH

      40.31 8 Things to Know about Mind and Body Approaches for Health

      Problems Facing Military Personnel and Veterans

      40.32 5 Tips: What You Should Know about Tai Chi for Health

      40.33 6 Things to Know about Complementary Health Approaches for

      Seasonal Allergy Relief

      40.34 7 Tips: What You Should Know about Complementary Health

      Approaches for Multiple Sclerosis

      40.35 7 Things to Know about Complementary Health Approaches for

      Anxiety

      40.36 6 Tips: What You Need to Know about Complementary Health

      Approaches for Skin Conditions

      40.37 5 Things to Know about Complementary Health Approaches for

      Parkinson’s Disease

      40.38 5 Myths about Popular Natural Products Marketed for Disease

      Prevention and Wellness

      40.39 7 Things to Know about Mind and Body Practices for Children

      and Teens

      40.40 6 Things to Know about Travel-Related Ailments and

      Complementary Health Approaches

      40.41 6 Tips: IBS and Complementary Health Practices

      40.42 5 Things You Should Know about Dietary Supplements for

      Hepatitis C

      40.43 5 Things to Know about Probiotics

      40.44 5 Things to Know about Mind and Body Approaches for

      Substance Use Disorders

      40.45 4 Things to Know about Menopausal Symptoms and

      Complementary Health Practices

      40.46 6 Things to Know When Selecting a Complementary Health

      Practitioner

      40.47 5 Tips: What You Should Know about Popular Herbs

      40.48 8 Things to Know about Meditation for Health

      40.49 6 Things to Know about Complementary Health Approaches for

      Quitting Smoking

      40.50 5 Tips: What You Should Know about High Blood Cholesterol

      40.51 8 Things to Know about Depression and Complementary Health

      Approaches

      40.52 10 Things to Know about Dietary Supplements for Children and

      Teens

      40.53 4 Things To Know About Menopausal Symptoms and

      Complementary Health Practices

      40.54 Ayurvedic Medicine: In Depth

      40.55 Terms Related to Complementary and Integrative Health

      41. Skin Conditions and Complementary Health Approaches: What the

      Science Says

      National Institutes of Health

      41.1 Atopic Dermatitis

      41.2 Psoriasis

      41.3 Acne

      41.4 Impetigo

      41.5 Rosacea

      42. Nutrition and Health across the Lifespan: Guidelines and

      Recommendations

      U.S. Department of Agriculture

      42.1 Guideline 1: Follow a Healthy Dietary Pattern at Every Life Stage

      42.2 Guideline 2: Customize and Enjoy Food and Beverage Choices

      to Reflect Personal Preferences, Cultural Traditions, and

      Budgetary Considerations

      42.3 Guideline 3: Focus on Meeting Food Group Needs With

      Nutrient-Dense Foods and Beverages, and Stay Within Calorie

      Limits

      42.4 Guideline 4: Limit Foods and Beverages Higher in Added Sugars,

      Saturated Fat, and Sodium, and Limit Alcoholic Beverages

      42.5 Support Healthy Dietary Patterns for All Americans

      43. Using Dietary Supplements Wisely

      National Institutes of Health

      43.1 What’s the Bottom Line?

      43.2 What Are Dietary Supplements?

      43.3 What Are Herbal Supplements?

      43.4 Dietary Supplement Use in the United States

      43.5 Federal Regulation of Dietary Supplements

      43.6 What the Science Says about the Effectiveness of Dietary

      Supplements

      43.7 What the Science Says about the Safety and Side Effects of

      Dietary Supplements

      43.8 Safety Considerations

      44. Association of Genetic Liability to Smoking Initiation with e-Cigarette

      Use in Young Adults: A Cohort Study

      44.1 Introduction

      44.2 Results

      44.3 Discussion

      45. Current Issues in Vaccine Development

      45.1 Vaccine Development: An Introductory Overview

      45.2 How Vaccines Work

      45.3 Vaccine Development

      45.4 Improving Vaccine R&D

      45.5 Technologies and Approaches for Vaccine R&D

      45.6 Addressing Challenges Related to Vaccine R&D: Policy Options

      45.7 Technologies and Approaches That May Enhance Vaccine Testing

      45.8 Challenges Related to Vaccine Testing: Policy Options

      45.9 Technologies and Approaches for Vaccine Manufacturing

      45.10 Challenges Related to Vaccine Manufacturing: Policy Options

      45.11 Vaccine Development: Economics and Role of Incentives

      45.12 Economic Challenges to Vaccine Development: Policy Options

      46. Cannabis Products Containing Delta-8 Tetrahydrocannabinol:

      Increased Availability and Reports of Adverse Events

      Centers for Disease Control and Prevention

      46.1 Introduction

      46.2 Background

      46.3 Recommendations for the Public and Consumers

      46.4 Recommendations for Public Health Departments and Poison

      Control Centers, Including Those in Locations Where Laws Only

      Permit Hemp Marketplaces

      46.5 Recommendations for Retailers Selling Cannabis Products 1013

      46.6 Recommendations for Healthcare Providers

      46.7 For More Information

      47. Natural Doesn’t Necessarily Mean Safer, or Better

      National Institutes of Health

      48. How Medications and Supplements Can Interact

      National Institutes of Health

      48.1 Test Your Knowledge: Are These Statements True or False?

      48.2 Talk With Your Health Care Providers

      48.3 Some Supplements May Increase the Effects—and Side

      Effects—of Drugs

      48.4 Some Supplements May Decrease the Effects of Drugs

      48.5 More about St. John’s Wort

      48.6 Interactions with Over-the-Counter Drugs

      48.7 When Drug-Supplement Interactions Are Especially Important

      48.8 Drugs with a Narrow Therapeutic Range

      48.9 If You’re Going to Have Surgery

      48.10 Tips on Reading Supplement Labels

      48.11 Here’s a Hint for Your Next Visit to a Health Care Provider

      49. Antioxidants: Current Issues and Future Trends

      National Institutes of Health

      49.1 Introduction

      49.2 Key Points

      49.3 About Free Radicals, Oxidative Stress, and Antioxidants

      49.4 Use of Antioxidant Supplements in the United States

      49.5 Safety

      49.6 What the Science Says

      49.7 If You Are Considering Antioxidant Supplements

      49.8 NCCIH- and NIH-Funded Research

      49.9 For More Information

      50. Hearing Loss and Hearing Aids: Current Issues

      50.1 What Is Hearing Loss?

      50.2 What Noises Cause Hearing Loss?

      50.3 How Does Loud Noise Cause Hearing Loss?

      50.4 What Is Noise-Induced Hearing Loss?

      50.5 How Can I Tell If I Have a Hearing Problem?

      50.6 Who Can I Turn to for Help with My Hearing Loss?

      50.7 Why Am I Losing My Hearing?

      50.8 What Is an Audiogram?

      50.9 What Treatments and Devices Can Help?

      50.10 Hearing Aids: More Details

      50.11 What Are Some Features for Hearing Aids?

      50.12 Hearing Aids and How They Work

      50.13 Are There Different Styles of Hearing Aids?

      50.14 Are New Types of Aids Available?

      50.15 What Is the Difference between Analog and Digital Hearing Aids?

      50.16 Which Hearing Aid Will Work Best for Me?

      50.17 How Do I Get a Hearing Evaluation before Getting Hearing Aids?

      50.18 What Is the Difference between Prescription and Over-the

      Counter Hearing Aids?

      50.19 Who Are OTC Hearing Aids for?

      50.20 What Questions Should I Ask before Buying a Hearing Aid?

      50.21 How Can I Adjust to My Hearing Aid?

      50.22 How Can I Care for My Hearing Aid? 1075

      50.23 Can I Obtain Financial Assistance for a Hearing Aid?

      50.24 Hearing Aids vs. Personal Sound Amplification Products

      51. Bacterial Evolution during Human Infection: Adapt and Live or Adapt

      and Die

      51.1 Introduction

      51.2 Conclusions

      52. Roadblocks in Chagas Disease Care in Endemic and Nonendemic

      Countries: Argentina, Colombia, Spain, and the United States.

      The NET-Heart Project

      52.1 Introduction

      52.2 Methods

      52.3 Results

      52.4 Discussion

      52.5 Conclusions

      53. Pathogens Infecting the Central Nervous System

      54. Current Issues in Vaccines

      Centers for Disease Control and Prevention

      54.1 History of Vaccines

      54.2 Common Ingredients in U.S. Licensed Vaccines

      54.3 Understanding the Vaccine Adverse Event Reporting System

      54.4 Science Summary: CDC Studies on Thimerosal in Vaccines

      54.5 Pregnancy and Vaccination

      54.6 Understanding Thimerosal, Mercury, and Vaccine Safety

      54.7 2022 Recommended Immunizations for Children from Birth

      through 6 Years Old

      54.8 2022 Recommended Immunizations for Children 7–18 Years

      54.9 Recommended Adult Immunization Schedule for Ages 19 Years

      or Older

      55. What Are Embryonic Stem Cells and How Can They Help Us?

      55.1 It All Begins in Fertilization, When the Sperm Meets the Egg

      55.2 Cloning

      55.3 Therapeutic Cloning

      55.4 Reprogramming

      55.5 Therapy?

      55.6 Addendum by the Series Editor, Dr. Raj Bawa: The Future of

      Embryonic Stem Cells

      56. The Rise and Rise of Mitochondrial DNA Mutations

      56.1 Evolutionary Aspects of Mitochondrial Genetics

      56.2 Clonal Expansion of mtDNA Mutations

      56.3 Population Dynamics of mtDNA Point Mutations

      56.4 Population Dynamics of mtDNA Deletions

      56.5 Important Challenges and Unanswered Questions

      56.6 Modelling Clonal Expansion

      56.7 Conclusion and Future Perspectives

      57. Hallmarks of Cancer—the New Testament

      57.1 A Historical Perspective on Cancer

      57.2 Hallmarks of Cancer

      57.3 New Hallmark 1: Dedifferentiation and Transdifferentiation

      57.4 New Hallmark 2: Epigenetic Dysregulation

      57.5 New Hallmark 3: Altered Microbiome

      57.6 New Hallmark 4: Altered Neuronal Signalling

      57.7 Conclusion

      58. Adipose Tissue in Health and Disease

      58.1 Introduction

      58.2 Adipose Tissue Expansion and Development

      58.3 Inflammation

      58.4 Location of Lipid Storage

      58.5 Adipose Tissue Lipolysis and Insulin Resistance

      58.6 Endocrine Functions within Adipose Tissue

      58.7 Emerging Approaches to Combat Adipose Tissue-Derived

      Metabolic Dysfunction

      58.8 Concluding Remarks

      59. Viral Pathogenesis of SARS-CoV-2 Infection and Male Reproductive

      Health

      59.1 Introduction

      59.2 SARS-CoV-2: History, Origin and Transmission

      59.3 Possible Mechanism of SARS-CoV-2 Invasion into Host Cells and

      Immune Pattern of Infection

      59.4 Effect on the Male Reproductive System

      59.5 SARS-CoV-2 and Male Fertility

      59.6 Gender-Based Susceptibility

      59.7 Conclusion

      59.8 Future Perspectives

      60. Elevated CO2 Modulates Airway Contractility

      60.1 Introduction

      60.2 Hypercapnia-Induced Bronchoconstriction

      60.3 Respiratory Acidosis-Related Bronchodilation

      60.4 Effect of Hypocapnia on Airway Contractility

      60.5 Conclusion

      Index

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