Description

Book Synopsis
  • The Current Issues in Medicine series not only highlights current advances but also explores related topics such as translational medicine, regulatory science, neglected diseases, global pandemics, patent law, immunotoxicology, ethics, theranostics, big data, artificial intelligence, novel imaging tools, combination drug products, and novel therapies.
  • Volumes 1 and 2 in this series are focused on current issues in basic medical science, subjects that are fundamental to the practice of medicine. Specifically, volume 1 covers biochemistry, genomics, physiology, and pharmacology.


Table of Contents

Corresponding Authors

Note from the Series Editor

1. Surgical and Medical Specialties: A Journey in Pictures

2. Lymph Nodes—The Neglected Battlefield in Tuberculosis

2.1 Introduction

2.2 Concluding Remarks

2.3 Methods

3. Chronic Kidney Disease in the United States, 2021

Centers for Disease Control and Prevention

3.1 CKD Is Common Among US Adults

3.2 CKD by Age, Sex, and Race/Ethnicity

3.3 CKD Risk Factors

3.4 Ways to Prevent CKD

3.5 Treatment to Lower Blood Pressure

3.6 Testing and Treatment: Find It Early, Treat It Early

3.7 CKD Related Health Problems

3.8 People with CKD Can Lower Their Risk for Kidney Failure

4. Combatting Sepsis: A Public Health Perspective

4.1 National Trends in Sepsis Burden

4.2 Comprehensive Sepsis Prevention Framework

4.3 Building Partnerships and Increasing Awareness

4.4 Future Public Health Opportunities and Challenges

5. Hypertension and Atrial Fibrillation: Closing a Virtuous Circle

6. Cardiovascular Events after Community-Acquired Pneumonia:

A Global Perspective with Systematic Review and Meta-Analysis of

Observational Studies

6.1 Introduction

6.2 Materials and Methods

6.3 Results

6.4 Discussion

6.5 Future Directions

7. Risk Factors for Recurrent Arterial Ischemic Stroke in Children and

Young Adults

7.1 Introduction

7.2 Review Methodology

7.3 Prevalence of AIS Recurrence

7.4 Risk Factors for Recurrent AIS in a Pediatric Population

7.5 Risk Factors for Recurrent AIS in Young Adults

7.6 Secondary Prevention of AIS

7.7 Conclusions

8. Cellular Mechanisms of Human Atherogenesis: Focus on Chronification

of Inflammation and Mitochondrial Mutations

8.1 Introduction

8.2 Cellular Mechanisms of Atherogenesis

8.3 Variants of the Nuclear Genome Associated with Atherosclerosis

8.4 Variants of Mitochondrial Genome Associated with

Atherosclerosis

8.5 Role of Mitochondrial Mutations in Cellular Mechanism of

Atherosclerosis; Chronification of Inflammation

8.6 Conclusions

9. The Microbiota of the Human Gut and Cardiometabolic Health

9.1 Introduction

9.2 The Microbiome

9.3 Major Metabolic Contributors to Microbiome Profile Identity

9.4 Dysbiosis and the Development of T2DM

9.5 Gut Microbiota and CVD

9.6 Concluding Remarks

10. Pharmaceutical Strategies for Reducing LDL-C and Risk of

Cardiovascular Disease

10.1 Introduction

10.2 The Importance of Potency in Statin Monotherapy

10.3 Alternative Strategies to Achieve LDL-C Goal

10.4 PCSK9, a New Therapeutic Target

10.5 Conclusion

11. Atherogenic Markers in Predicting Cardiovascular Risk and Targeting

Residual Cardiovascular Risk

11.1 Introduction

11.2 Markers of Atherogenic Risk

11.3 Residual Cardiovascular Risk

11.4 Conclusions

12. The Continuous Quest for More Effective and Safer

Thromboprophylaxis Protocols

12.1 Thrombosis: A Preventable Healthcare Burden

12.2 Implementation Strategies and Risk Stratification

12.3 Prophylaxis Options with Comparison of Their Efficacy and Risks

12.4 Screening Methods and Secondary Prophylaxis

12.5 New Horizons: Emerging Prophylaxis Methods, Screening

Strategies and Treatment Policies

12.6 Conclusion

13. Wound Healing: Cellular Mechanisms and Pathological Outcomes

13.1 Introduction

13.2 Cellular Aspects of Acute Wound Repair

13.3 When Healing Fails—Factors Influencing Chronic Wound

Healing

13.4 Translational Techniques to Enhance Clinical Understanding of

Wounds

13.5 Current Therapies and Future Opportunities

13.6 Conclusions

14. Advances in Cervical Cancer Prevention: Efficacy, Effectiveness,

Elimination?

14.1 Evolution of Human Papilloma Virus Vaccination

14.2 Prospects for Cervical Cancer Elimination

14.3 Opportunities and Challenges Posed by Resource Levels

14.4 Cervical Screening in the Presence of HPV Vaccination

14.5 Future Perspectives

15. Molecular Classification of Breast Cancer: A Retrospective Cohort

Study

15.1 Introduction

15.2 Materials and Methods

15.3 Results

15.4 Discussion

15.5 Conclusion

16. Cutaneous Squamous Cell Carcinoma: From Biology to Therapy

16.1 Introduction

16.2 Molecular Basis of CSCC

16.3 Treatment of CSCC

16.4 Pharmacologically Induced Cutaneous Squamous Cell Carcinoma

16.5 Conclusions

17. Brain and Testis: More Alike Than Previously Thought?

17.1 Introduction

17.2 Brain and Testis

17.3 Neuron and Sperm

17.4 Concluding Remarks

18. Myomatous Erythrocytosis Syndrome: A Case Series

18.1 Introduction

18.2 Results

18.3 Discussion

18.4 Conclusions

19. Vascular Involvements in Cholangiocarcinoma: Tips and Tricks

19.1 Introduction

19.2 Materials and Methods

19.3 Intrahepatic Cholangiocarcinoma with Vascular Involvement

19.4 Perihilar Cholangiocarcinoma with Vascular Involvement

19.5 Conclusions

20. Rehabilitation for People Living with Dementia: A Practical

Framework of Positive Support

20.1 Why Is Rehabilitation Relevant?

20.2 How Can Cognitive Rehabilitation Benefit People with Dementia

and Carers?

20.3 Where Do Other Nonpharmacological Interventions Fit In?

20.4 How Could Services Adopt a Rehabilitation Model?

20.5 Why Should We Acknowledge the Right to Rehabilitation?

21. Are Dementia with Lewy Bodies and Parkinson’s Disease Dementia

the Same Disease?

21.1 Background

21.2 Conclusions

21.3 Future Perspectives

22. Regenerative Medicine: Could Parkinson’s Be the First

Neurodegenerative Disease to Be Cured?

22.1 Multiplication and Differentiation of NSCs

22.2 Production, Transplantation and Characterization of Precursor

DOP Aminergic Neurons

22.3 Rejection of Transplanted Cells

22.4 From Bench to Bed

22.5 Future Perspective

23. Changes in the Functional Brain Network of Children Undergoing

Repeated Epilepsy Surgery: An EEG Source Connectivity Study

23.1 Introduction

23.2 Materials and Methods

23.3 Results

23.4 Discussion

23.5 Conclusions

24. Blood–Brain Barrier Disruption in Atrial Fibrillation: A Potential

Contributor to the Increased Risk of Dementia and Worsening of

Stroke Outcomes

24.1 Introduction

24.2 The Structure and Function of the Blood–Brain Barrier

24.3 Mechanisms of Blood–Brain Barrier Disruption

24.4 Effects of Altered Cerebral Blood Flow on the Blood–Brain

Barrier

24.5 Disrupted Peripheral and Cerebral Blood Flow in Atrial

Fibrillation

24.6 What Are the Underlying Mechanisms that Increase the Risk

of Stroke and Dementia in Atrial Fibrillation?

24.7 Concluding Remarks

25. Trauma-Induced Coagulopathy: From Pathophysiology to

Outcomes—Overview of an Emerging Medical Problem

25.1 Introduction

25.2 Definition

25.3 Pathophysiology

25.4 Specials Clinical Forms of TIC

25.5 Diagnosis

25.6 Outcomes

25.7 Hints for Therapy

25.8 Management of Patients with Severe Trauma in an ER

26. Advances in Fractures and Dislocations of the Hip Joint

26.1 Hip Fractures

26.2 Traumatic Dislocations of the Hip Joint

27. Predicting Scoliosis Progression: A Challenge for Researchers and

Clinicians

28. Prosthetic and Mechanical Parameters of the Facial Bone under the

Load of Different Dental Implant Shapes: A Parametric Study

28.1 Introduction

28.2 Results

28.3 Discussion

28.4 Materials and Methods

28.5 Conclusions

29. Circulating Arsenic Is Associated with Long-Term Risk of Graft Failure

in Kidney Transplant Recipients: A Prospective Cohort Study

29.1 Introduction

29.2 Methods

29.3 Results

29.4 Discussion

29.5 Conclusions

30. Successful Aging and Chronic Osteoarthritis

Ray Marks, EdD

30.1 Introduction

30.2 Methods

30.3 Results

30.4 Discussion

30.5 Conclusions

30.6 Future Research and Practical Challenges

31. Radiographic Analysis on the Distortion of the Anatomy of First

Metatarsal Head in Dorsoplantar Projection

31.1 Introduction

31.2 Material and Methods

31.3 Results

31.4 Discussion

31.5 Conclusions

32. Clinical Aspects and Current Therapeutic Approaches for Fibrodysplasia

Ossificans Progressiva

32.1 Introduction

32.2 Epidemiology

32.3 Pathophysiology

32.4 Natural Clinical Course

32.5 Skeletal Malformations

32.6 Managements and Treatments

32.7 On-Going Clinical Trials for FOP

32.8 Conclusions

33. Comparison and Lessons Learned from Neglected Tropical Diseases

and Tuberculosis

33.1 Introduction

33.2 Underlying Burden of Disease

33.3 Influence of Poverty and Development

33.4 Neglect

33.5 Conclusions

34. Current Issues in Antibiotic Antimicrobial Resistance

Centers for Disease Control and Prevention

34.1 About Antibiotic Resistance

34.2 Antibiotic Resistance Threatens Everyone

34.3 Brief History of Resistance and Antibiotics

34.4 Fighting Antibiotic Resistance

34.5 Antibiotic Resistance: 5 Things to Know

34.6 Antibiotic-Resistant Infections Threaten Modern Medicine

34.7 Examples of How Antibiotic Resistance Affects Humans, Animals

and the Environment

34.8 How Antibiotic Resistance Moves Directly Germ to Germ

34.9 Protect People and Animals, Combat Antibiotic Resistance:

Actions for Livestock and Poultry Producers

35. Ending AIDS as a Public Health Threat by 2030: Time to Reset Targets

for 2025

35.1 Introduction

35.2 The Process and Structures

35.3 Addressing the Key Challenges, Concerns, and Priorities

35.4 Conclusions

36. 9 Questions to Help Make Sense of Health Research

National Institutes of Health

37. Transdisciplinary Research and Clinical Priorities for Better Health

37.1 Lifestyle and Prevention of Chronic Diseases

37.2 Intergenerational and Life Course Consequences of

Preconception and in utero Health

37.3 Ecological Footprint of Modern Medical Systems

37.4 Intensive Animal Farming and Pollution

37.5 Benefits of Investing in Preventive Science, Education,

and Medicine

37.6 Conclusions and Future Directions

38. Current Issues about Health News Stories

National Institutes of Health

38.1 When Clinical Research is in the News

38.2 Health Approaches in the News

38.3 Information Missing from Health Stories

38.4 What’s Missing: Important Details!

38.5 What’s Missing: Information on Side Effects!

38.6 What’s Missing: The Full Story!

38.7 What’s Missing: Humans!

38.8 Conflicting Health News

38.9 Accuracy in the Media

38.10 What the Media Says about Complementary Health Approaches

38.11 Is It Real Online News? Or Just Advertising?

38.12 Checklist for Understanding Health News Stories

38.13 Remember…

38.14 Supplementary Information

39. Complementary, Alternative, or Integrative Health: What’s in

a Name?

National Institutes of Health

39.1 Complementary versus Alternative

39.2 Integrative Health

39.3 Complementary Health Approaches

40. Current Issues in Complementary and Integrative Health

National Institutes of Health

40.1 4 Things to Know about Dietary Supplements for Eye Conditions

40.2 5 Things to Know about Omega-3s for Heart Disease

40.3 6 Tips: How Herbs Can Interact with Medicines

40.4 7 Tips: What You Need to Know about Natural Products for

Musculoskeletal Inflammation

40.5 6 Things You Should Know: The Science of Chronic Pain and

Complementary Health Practices

40.6 4 Tips: Mind and Body Practices for Common Aging-Related

Conditions

40.7 6 Things You Need to Know about Cancer and Complementary

Health Approaches

40.8 5 Things to Know about Complementary Health Practices for

Cognitive Function, Dementia, and Alzheimer’s Disease

40.9 4 Tips: Asthma and Complementary Health Practices

40.10 10 Things to Know about the Science of Health

40.11 5 Things to Know about Relaxation Techniques for Stress

40.12 7 Things to Know about Complementary Approaches for

Fibromyalgia

40.13 5 Tips: Natural Products for the Flu and Colds: What Does the

Science Say?

40.14 5 Things You Should Know about Yoga

40.15 5 Things to Know about Chronic Low-Back Pain and

Complementary Health Practices

40.16 4 Things to Know about Spinal Manipulation for Low-Back Pain

40.17 7 Things to Know about Complementary Health Approaches for

Autism Spectrum Disorder

40.18 4 Tips: Start Talking with Your Health Care Providers about

Complementary Health Approaches

40.19 7 Things to Know about Omega-3 Fatty Acids

40.20 5 Tips: Natural Products Used for Common Aging-Related

Conditions

40.21 6 Things You Should Know about Dietary Supplements for

Osteoarthritis

40.22 7 Tips: Know the Facts about Supplements Marketed for Weight

Loss

40.23 5 Things to Know about Sleep Disorders and Complementary

Health Approaches

40.24 6 Things to Know about Complementary Health Approaches for

Seasonal Affective Disorder

40.25 5 Tips: What Consumers Need to Know about Dietary Supplements

40.26 5 Things to Know about St. John’s Wort and Depression

40.27 6 Things to Know about Massage Therapy for Health Purposes

40.28 7 Things to Know about Complementary Health Approaches for

ADHD

40.29 6 Things to Know about Type 2 Diabetes and Dietary Supplements

40.30 5 Tips: What You Should Know about Complementary Health

Approaches for BPH

40.31 8 Things to Know about Mind and Body Approaches for Health

Problems Facing Military Personnel and Veterans

40.32 5 Tips: What You Should Know about Tai Chi for Health

40.33 6 Things to Know about Complementary Health Approaches for

Seasonal Allergy Relief

40.34 7 Tips: What You Should Know about Complementary Health

Approaches for Multiple Sclerosis

40.35 7 Things to Know about Complementary Health Approaches for

Anxiety

40.36 6 Tips: What You Need to Know about Complementary Health

Approaches for Skin Conditions

40.37 5 Things to Know about Complementary Health Approaches for

Parkinson’s Disease

40.38 5 Myths about Popular Natural Products Marketed for Disease

Prevention and Wellness

40.39 7 Things to Know about Mind and Body Practices for Children

and Teens

40.40 6 Things to Know about Travel-Related Ailments and

Complementary Health Approaches

40.41 6 Tips: IBS and Complementary Health Practices

40.42 5 Things You Should Know about Dietary Supplements for

Hepatitis C

40.43 5 Things to Know about Probiotics

40.44 5 Things to Know about Mind and Body Approaches for

Substance Use Disorders

40.45 4 Things to Know about Menopausal Symptoms and

Complementary Health Practices

40.46 6 Things to Know When Selecting a Complementary Health

Practitioner

40.47 5 Tips: What You Should Know about Popular Herbs

40.48 8 Things to Know about Meditation for Health

40.49 6 Things to Know about Complementary Health Approaches for

Quitting Smoking

40.50 5 Tips: What You Should Know about High Blood Cholesterol

40.51 8 Things to Know about Depression and Complementary Health

Approaches

40.52 10 Things to Know about Dietary Supplements for Children and

Teens

40.53 4 Things To Know About Menopausal Symptoms and

Complementary Health Practices

40.54 Ayurvedic Medicine: In Depth

40.55 Terms Related to Complementary and Integrative Health

41. Skin Conditions and Complementary Health Approaches: What the

Science Says

National Institutes of Health

41.1 Atopic Dermatitis

41.2 Psoriasis

41.3 Acne

41.4 Impetigo

41.5 Rosacea

42. Nutrition and Health across the Lifespan: Guidelines and

Recommendations

U.S. Department of Agriculture

42.1 Guideline 1: Follow a Healthy Dietary Pattern at Every Life Stage

42.2 Guideline 2: Customize and Enjoy Food and Beverage Choices

to Reflect Personal Preferences, Cultural Traditions, and

Budgetary Considerations

42.3 Guideline 3: Focus on Meeting Food Group Needs With

Nutrient-Dense Foods and Beverages, and Stay Within Calorie

Limits

42.4 Guideline 4: Limit Foods and Beverages Higher in Added Sugars,

Saturated Fat, and Sodium, and Limit Alcoholic Beverages

42.5 Support Healthy Dietary Patterns for All Americans

43. Using Dietary Supplements Wisely

National Institutes of Health

43.1 What’s the Bottom Line?

43.2 What Are Dietary Supplements?

43.3 What Are Herbal Supplements?

43.4 Dietary Supplement Use in the United States

43.5 Federal Regulation of Dietary Supplements

43.6 What the Science Says about the Effectiveness of Dietary

Supplements

43.7 What the Science Says about the Safety and Side Effects of

Dietary Supplements

43.8 Safety Considerations

44. Association of Genetic Liability to Smoking Initiation with e-Cigarette

Use in Young Adults: A Cohort Study

44.1 Introduction

44.2 Results

44.3 Discussion

45. Current Issues in Vaccine Development

45.1 Vaccine Development: An Introductory Overview

45.2 How Vaccines Work

45.3 Vaccine Development

45.4 Improving Vaccine R&D

45.5 Technologies and Approaches for Vaccine R&D

45.6 Addressing Challenges Related to Vaccine R&D: Policy Options

45.7 Technologies and Approaches That May Enhance Vaccine Testing

45.8 Challenges Related to Vaccine Testing: Policy Options

45.9 Technologies and Approaches for Vaccine Manufacturing

45.10 Challenges Related to Vaccine Manufacturing: Policy Options

45.11 Vaccine Development: Economics and Role of Incentives

45.12 Economic Challenges to Vaccine Development: Policy Options

46. Cannabis Products Containing Delta-8 Tetrahydrocannabinol:

Increased Availability and Reports of Adverse Events

Centers for Disease Control and Prevention

46.1 Introduction

46.2 Background

46.3 Recommendations for the Public and Consumers

46.4 Recommendations for Public Health Departments and Poison

Control Centers, Including Those in Locations Where Laws Only

Permit Hemp Marketplaces

46.5 Recommendations for Retailers Selling Cannabis Products 1013

46.6 Recommendations for Healthcare Providers

46.7 For More Information

47. Natural Doesn’t Necessarily Mean Safer, or Better

National Institutes of Health

48. How Medications and Supplements Can Interact

National Institutes of Health

48.1 Test Your Knowledge: Are These Statements True or False?

48.2 Talk With Your Health Care Providers

48.3 Some Supplements May Increase the Effects—and Side

Effects—of Drugs

48.4 Some Supplements May Decrease the Effects of Drugs

48.5 More about St. John’s Wort

48.6 Interactions with Over-the-Counter Drugs

48.7 When Drug-Supplement Interactions Are Especially Important

48.8 Drugs with a Narrow Therapeutic Range

48.9 If You’re Going to Have Surgery

48.10 Tips on Reading Supplement Labels

48.11 Here’s a Hint for Your Next Visit to a Health Care Provider

49. Antioxidants: Current Issues and Future Trends

National Institutes of Health

49.1 Introduction

49.2 Key Points

49.3 About Free Radicals, Oxidative Stress, and Antioxidants

49.4 Use of Antioxidant Supplements in the United States

49.5 Safety

49.6 What the Science Says

49.7 If You Are Considering Antioxidant Supplements

49.8 NCCIH- and NIH-Funded Research

49.9 For More Information

50. Hearing Loss and Hearing Aids: Current Issues

50.1 What Is Hearing Loss?

50.2 What Noises Cause Hearing Loss?

50.3 How Does Loud Noise Cause Hearing Loss?

50.4 What Is Noise-Induced Hearing Loss?

50.5 How Can I Tell If I Have a Hearing Problem?

50.6 Who Can I Turn to for Help with My Hearing Loss?

50.7 Why Am I Losing My Hearing?

50.8 What Is an Audiogram?

50.9 What Treatments and Devices Can Help?

50.10 Hearing Aids: More Details

50.11 What Are Some Features for Hearing Aids?

50.12 Hearing Aids and How They Work

50.13 Are There Different Styles of Hearing Aids?

50.14 Are New Types of Aids Available?

50.15 What Is the Difference between Analog and Digital Hearing Aids?

50.16 Which Hearing Aid Will Work Best for Me?

50.17 How Do I Get a Hearing Evaluation before Getting Hearing Aids?

50.18 What Is the Difference between Prescription and Over-the

Counter Hearing Aids?

50.19 Who Are OTC Hearing Aids for?

50.20 What Questions Should I Ask before Buying a Hearing Aid?

50.21 How Can I Adjust to My Hearing Aid?

50.22 How Can I Care for My Hearing Aid? 1075

50.23 Can I Obtain Financial Assistance for a Hearing Aid?

50.24 Hearing Aids vs. Personal Sound Amplification Products

51. Bacterial Evolution during Human Infection: Adapt and Live or Adapt

and Die

51.1 Introduction

51.2 Conclusions

52. Roadblocks in Chagas Disease Care in Endemic and Nonendemic

Countries: Argentina, Colombia, Spain, and the United States.

The NET-Heart Project

52.1 Introduction

52.2 Methods

52.3 Results

52.4 Discussion

52.5 Conclusions

53. Pathogens Infecting the Central Nervous System

54. Current Issues in Vaccines

Centers for Disease Control and Prevention

54.1 History of Vaccines

54.2 Common Ingredients in U.S. Licensed Vaccines

54.3 Understanding the Vaccine Adverse Event Reporting System

54.4 Science Summary: CDC Studies on Thimerosal in Vaccines

54.5 Pregnancy and Vaccination

54.6 Understanding Thimerosal, Mercury, and Vaccine Safety

54.7 2022 Recommended Immunizations for Children from Birth

through 6 Years Old

54.8 2022 Recommended Immunizations for Children 7–18 Years

54.9 Recommended Adult Immunization Schedule for Ages 19 Years

or Older

55. What Are Embryonic Stem Cells and How Can They Help Us?

55.1 It All Begins in Fertilization, When the Sperm Meets the Egg

55.2 Cloning

55.3 Therapeutic Cloning

55.4 Reprogramming

55.5 Therapy?

55.6 Addendum by the Series Editor, Dr. Raj Bawa: The Future of

Embryonic Stem Cells

56. The Rise and Rise of Mitochondrial DNA Mutations

56.1 Evolutionary Aspects of Mitochondrial Genetics

56.2 Clonal Expansion of mtDNA Mutations

56.3 Population Dynamics of mtDNA Point Mutations

56.4 Population Dynamics of mtDNA Deletions

56.5 Important Challenges and Unanswered Questions

56.6 Modelling Clonal Expansion

56.7 Conclusion and Future Perspectives

57. Hallmarks of Cancer—the New Testament

57.1 A Historical Perspective on Cancer

57.2 Hallmarks of Cancer

57.3 New Hallmark 1: Dedifferentiation and Transdifferentiation

57.4 New Hallmark 2: Epigenetic Dysregulation

57.5 New Hallmark 3: Altered Microbiome

57.6 New Hallmark 4: Altered Neuronal Signalling

57.7 Conclusion

58. Adipose Tissue in Health and Disease

58.1 Introduction

58.2 Adipose Tissue Expansion and Development

58.3 Inflammation

58.4 Location of Lipid Storage

58.5 Adipose Tissue Lipolysis and Insulin Resistance

58.6 Endocrine Functions within Adipose Tissue

58.7 Emerging Approaches to Combat Adipose Tissue-Derived

Metabolic Dysfunction

58.8 Concluding Remarks

59. Viral Pathogenesis of SARS-CoV-2 Infection and Male Reproductive

Health

59.1 Introduction

59.2 SARS-CoV-2: History, Origin and Transmission

59.3 Possible Mechanism of SARS-CoV-2 Invasion into Host Cells and

Immune Pattern of Infection

59.4 Effect on the Male Reproductive System

59.5 SARS-CoV-2 and Male Fertility

59.6 Gender-Based Susceptibility

59.7 Conclusion

59.8 Future Perspectives

60. Elevated CO2 Modulates Airway Contractility

60.1 Introduction

60.2 Hypercapnia-Induced Bronchoconstriction

60.3 Respiratory Acidosis-Related Bronchodilation

60.4 Effect of Hypocapnia on Airway Contractility

60.5 Conclusion

Index

Advances in Surgical and Medical Specialties

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    Publisher: Jenny Stanford Publishing
    Publication Date: 14/07/2023
    ISBN13: 9789814877459, 978-9814877459
    ISBN10: 981487745X
    Also in:
    Surgery

    Description

    Book Synopsis
    • The Current Issues in Medicine series not only highlights current advances but also explores related topics such as translational medicine, regulatory science, neglected diseases, global pandemics, patent law, immunotoxicology, ethics, theranostics, big data, artificial intelligence, novel imaging tools, combination drug products, and novel therapies.
    • Volumes 1 and 2 in this series are focused on current issues in basic medical science, subjects that are fundamental to the practice of medicine. Specifically, volume 1 covers biochemistry, genomics, physiology, and pharmacology.


    Table of Contents

    Corresponding Authors

    Note from the Series Editor

    1. Surgical and Medical Specialties: A Journey in Pictures

    2. Lymph Nodes—The Neglected Battlefield in Tuberculosis

    2.1 Introduction

    2.2 Concluding Remarks

    2.3 Methods

    3. Chronic Kidney Disease in the United States, 2021

    Centers for Disease Control and Prevention

    3.1 CKD Is Common Among US Adults

    3.2 CKD by Age, Sex, and Race/Ethnicity

    3.3 CKD Risk Factors

    3.4 Ways to Prevent CKD

    3.5 Treatment to Lower Blood Pressure

    3.6 Testing and Treatment: Find It Early, Treat It Early

    3.7 CKD Related Health Problems

    3.8 People with CKD Can Lower Their Risk for Kidney Failure

    4. Combatting Sepsis: A Public Health Perspective

    4.1 National Trends in Sepsis Burden

    4.2 Comprehensive Sepsis Prevention Framework

    4.3 Building Partnerships and Increasing Awareness

    4.4 Future Public Health Opportunities and Challenges

    5. Hypertension and Atrial Fibrillation: Closing a Virtuous Circle

    6. Cardiovascular Events after Community-Acquired Pneumonia:

    A Global Perspective with Systematic Review and Meta-Analysis of

    Observational Studies

    6.1 Introduction

    6.2 Materials and Methods

    6.3 Results

    6.4 Discussion

    6.5 Future Directions

    7. Risk Factors for Recurrent Arterial Ischemic Stroke in Children and

    Young Adults

    7.1 Introduction

    7.2 Review Methodology

    7.3 Prevalence of AIS Recurrence

    7.4 Risk Factors for Recurrent AIS in a Pediatric Population

    7.5 Risk Factors for Recurrent AIS in Young Adults

    7.6 Secondary Prevention of AIS

    7.7 Conclusions

    8. Cellular Mechanisms of Human Atherogenesis: Focus on Chronification

    of Inflammation and Mitochondrial Mutations

    8.1 Introduction

    8.2 Cellular Mechanisms of Atherogenesis

    8.3 Variants of the Nuclear Genome Associated with Atherosclerosis

    8.4 Variants of Mitochondrial Genome Associated with

    Atherosclerosis

    8.5 Role of Mitochondrial Mutations in Cellular Mechanism of

    Atherosclerosis; Chronification of Inflammation

    8.6 Conclusions

    9. The Microbiota of the Human Gut and Cardiometabolic Health

    9.1 Introduction

    9.2 The Microbiome

    9.3 Major Metabolic Contributors to Microbiome Profile Identity

    9.4 Dysbiosis and the Development of T2DM

    9.5 Gut Microbiota and CVD

    9.6 Concluding Remarks

    10. Pharmaceutical Strategies for Reducing LDL-C and Risk of

    Cardiovascular Disease

    10.1 Introduction

    10.2 The Importance of Potency in Statin Monotherapy

    10.3 Alternative Strategies to Achieve LDL-C Goal

    10.4 PCSK9, a New Therapeutic Target

    10.5 Conclusion

    11. Atherogenic Markers in Predicting Cardiovascular Risk and Targeting

    Residual Cardiovascular Risk

    11.1 Introduction

    11.2 Markers of Atherogenic Risk

    11.3 Residual Cardiovascular Risk

    11.4 Conclusions

    12. The Continuous Quest for More Effective and Safer

    Thromboprophylaxis Protocols

    12.1 Thrombosis: A Preventable Healthcare Burden

    12.2 Implementation Strategies and Risk Stratification

    12.3 Prophylaxis Options with Comparison of Their Efficacy and Risks

    12.4 Screening Methods and Secondary Prophylaxis

    12.5 New Horizons: Emerging Prophylaxis Methods, Screening

    Strategies and Treatment Policies

    12.6 Conclusion

    13. Wound Healing: Cellular Mechanisms and Pathological Outcomes

    13.1 Introduction

    13.2 Cellular Aspects of Acute Wound Repair

    13.3 When Healing Fails—Factors Influencing Chronic Wound

    Healing

    13.4 Translational Techniques to Enhance Clinical Understanding of

    Wounds

    13.5 Current Therapies and Future Opportunities

    13.6 Conclusions

    14. Advances in Cervical Cancer Prevention: Efficacy, Effectiveness,

    Elimination?

    14.1 Evolution of Human Papilloma Virus Vaccination

    14.2 Prospects for Cervical Cancer Elimination

    14.3 Opportunities and Challenges Posed by Resource Levels

    14.4 Cervical Screening in the Presence of HPV Vaccination

    14.5 Future Perspectives

    15. Molecular Classification of Breast Cancer: A Retrospective Cohort

    Study

    15.1 Introduction

    15.2 Materials and Methods

    15.3 Results

    15.4 Discussion

    15.5 Conclusion

    16. Cutaneous Squamous Cell Carcinoma: From Biology to Therapy

    16.1 Introduction

    16.2 Molecular Basis of CSCC

    16.3 Treatment of CSCC

    16.4 Pharmacologically Induced Cutaneous Squamous Cell Carcinoma

    16.5 Conclusions

    17. Brain and Testis: More Alike Than Previously Thought?

    17.1 Introduction

    17.2 Brain and Testis

    17.3 Neuron and Sperm

    17.4 Concluding Remarks

    18. Myomatous Erythrocytosis Syndrome: A Case Series

    18.1 Introduction

    18.2 Results

    18.3 Discussion

    18.4 Conclusions

    19. Vascular Involvements in Cholangiocarcinoma: Tips and Tricks

    19.1 Introduction

    19.2 Materials and Methods

    19.3 Intrahepatic Cholangiocarcinoma with Vascular Involvement

    19.4 Perihilar Cholangiocarcinoma with Vascular Involvement

    19.5 Conclusions

    20. Rehabilitation for People Living with Dementia: A Practical

    Framework of Positive Support

    20.1 Why Is Rehabilitation Relevant?

    20.2 How Can Cognitive Rehabilitation Benefit People with Dementia

    and Carers?

    20.3 Where Do Other Nonpharmacological Interventions Fit In?

    20.4 How Could Services Adopt a Rehabilitation Model?

    20.5 Why Should We Acknowledge the Right to Rehabilitation?

    21. Are Dementia with Lewy Bodies and Parkinson’s Disease Dementia

    the Same Disease?

    21.1 Background

    21.2 Conclusions

    21.3 Future Perspectives

    22. Regenerative Medicine: Could Parkinson’s Be the First

    Neurodegenerative Disease to Be Cured?

    22.1 Multiplication and Differentiation of NSCs

    22.2 Production, Transplantation and Characterization of Precursor

    DOP Aminergic Neurons

    22.3 Rejection of Transplanted Cells

    22.4 From Bench to Bed

    22.5 Future Perspective

    23. Changes in the Functional Brain Network of Children Undergoing

    Repeated Epilepsy Surgery: An EEG Source Connectivity Study

    23.1 Introduction

    23.2 Materials and Methods

    23.3 Results

    23.4 Discussion

    23.5 Conclusions

    24. Blood–Brain Barrier Disruption in Atrial Fibrillation: A Potential

    Contributor to the Increased Risk of Dementia and Worsening of

    Stroke Outcomes

    24.1 Introduction

    24.2 The Structure and Function of the Blood–Brain Barrier

    24.3 Mechanisms of Blood–Brain Barrier Disruption

    24.4 Effects of Altered Cerebral Blood Flow on the Blood–Brain

    Barrier

    24.5 Disrupted Peripheral and Cerebral Blood Flow in Atrial

    Fibrillation

    24.6 What Are the Underlying Mechanisms that Increase the Risk

    of Stroke and Dementia in Atrial Fibrillation?

    24.7 Concluding Remarks

    25. Trauma-Induced Coagulopathy: From Pathophysiology to

    Outcomes—Overview of an Emerging Medical Problem

    25.1 Introduction

    25.2 Definition

    25.3 Pathophysiology

    25.4 Specials Clinical Forms of TIC

    25.5 Diagnosis

    25.6 Outcomes

    25.7 Hints for Therapy

    25.8 Management of Patients with Severe Trauma in an ER

    26. Advances in Fractures and Dislocations of the Hip Joint

    26.1 Hip Fractures

    26.2 Traumatic Dislocations of the Hip Joint

    27. Predicting Scoliosis Progression: A Challenge for Researchers and

    Clinicians

    28. Prosthetic and Mechanical Parameters of the Facial Bone under the

    Load of Different Dental Implant Shapes: A Parametric Study

    28.1 Introduction

    28.2 Results

    28.3 Discussion

    28.4 Materials and Methods

    28.5 Conclusions

    29. Circulating Arsenic Is Associated with Long-Term Risk of Graft Failure

    in Kidney Transplant Recipients: A Prospective Cohort Study

    29.1 Introduction

    29.2 Methods

    29.3 Results

    29.4 Discussion

    29.5 Conclusions

    30. Successful Aging and Chronic Osteoarthritis

    Ray Marks, EdD

    30.1 Introduction

    30.2 Methods

    30.3 Results

    30.4 Discussion

    30.5 Conclusions

    30.6 Future Research and Practical Challenges

    31. Radiographic Analysis on the Distortion of the Anatomy of First

    Metatarsal Head in Dorsoplantar Projection

    31.1 Introduction

    31.2 Material and Methods

    31.3 Results

    31.4 Discussion

    31.5 Conclusions

    32. Clinical Aspects and Current Therapeutic Approaches for Fibrodysplasia

    Ossificans Progressiva

    32.1 Introduction

    32.2 Epidemiology

    32.3 Pathophysiology

    32.4 Natural Clinical Course

    32.5 Skeletal Malformations

    32.6 Managements and Treatments

    32.7 On-Going Clinical Trials for FOP

    32.8 Conclusions

    33. Comparison and Lessons Learned from Neglected Tropical Diseases

    and Tuberculosis

    33.1 Introduction

    33.2 Underlying Burden of Disease

    33.3 Influence of Poverty and Development

    33.4 Neglect

    33.5 Conclusions

    34. Current Issues in Antibiotic Antimicrobial Resistance

    Centers for Disease Control and Prevention

    34.1 About Antibiotic Resistance

    34.2 Antibiotic Resistance Threatens Everyone

    34.3 Brief History of Resistance and Antibiotics

    34.4 Fighting Antibiotic Resistance

    34.5 Antibiotic Resistance: 5 Things to Know

    34.6 Antibiotic-Resistant Infections Threaten Modern Medicine

    34.7 Examples of How Antibiotic Resistance Affects Humans, Animals

    and the Environment

    34.8 How Antibiotic Resistance Moves Directly Germ to Germ

    34.9 Protect People and Animals, Combat Antibiotic Resistance:

    Actions for Livestock and Poultry Producers

    35. Ending AIDS as a Public Health Threat by 2030: Time to Reset Targets

    for 2025

    35.1 Introduction

    35.2 The Process and Structures

    35.3 Addressing the Key Challenges, Concerns, and Priorities

    35.4 Conclusions

    36. 9 Questions to Help Make Sense of Health Research

    National Institutes of Health

    37. Transdisciplinary Research and Clinical Priorities for Better Health

    37.1 Lifestyle and Prevention of Chronic Diseases

    37.2 Intergenerational and Life Course Consequences of

    Preconception and in utero Health

    37.3 Ecological Footprint of Modern Medical Systems

    37.4 Intensive Animal Farming and Pollution

    37.5 Benefits of Investing in Preventive Science, Education,

    and Medicine

    37.6 Conclusions and Future Directions

    38. Current Issues about Health News Stories

    National Institutes of Health

    38.1 When Clinical Research is in the News

    38.2 Health Approaches in the News

    38.3 Information Missing from Health Stories

    38.4 What’s Missing: Important Details!

    38.5 What’s Missing: Information on Side Effects!

    38.6 What’s Missing: The Full Story!

    38.7 What’s Missing: Humans!

    38.8 Conflicting Health News

    38.9 Accuracy in the Media

    38.10 What the Media Says about Complementary Health Approaches

    38.11 Is It Real Online News? Or Just Advertising?

    38.12 Checklist for Understanding Health News Stories

    38.13 Remember…

    38.14 Supplementary Information

    39. Complementary, Alternative, or Integrative Health: What’s in

    a Name?

    National Institutes of Health

    39.1 Complementary versus Alternative

    39.2 Integrative Health

    39.3 Complementary Health Approaches

    40. Current Issues in Complementary and Integrative Health

    National Institutes of Health

    40.1 4 Things to Know about Dietary Supplements for Eye Conditions

    40.2 5 Things to Know about Omega-3s for Heart Disease

    40.3 6 Tips: How Herbs Can Interact with Medicines

    40.4 7 Tips: What You Need to Know about Natural Products for

    Musculoskeletal Inflammation

    40.5 6 Things You Should Know: The Science of Chronic Pain and

    Complementary Health Practices

    40.6 4 Tips: Mind and Body Practices for Common Aging-Related

    Conditions

    40.7 6 Things You Need to Know about Cancer and Complementary

    Health Approaches

    40.8 5 Things to Know about Complementary Health Practices for

    Cognitive Function, Dementia, and Alzheimer’s Disease

    40.9 4 Tips: Asthma and Complementary Health Practices

    40.10 10 Things to Know about the Science of Health

    40.11 5 Things to Know about Relaxation Techniques for Stress

    40.12 7 Things to Know about Complementary Approaches for

    Fibromyalgia

    40.13 5 Tips: Natural Products for the Flu and Colds: What Does the

    Science Say?

    40.14 5 Things You Should Know about Yoga

    40.15 5 Things to Know about Chronic Low-Back Pain and

    Complementary Health Practices

    40.16 4 Things to Know about Spinal Manipulation for Low-Back Pain

    40.17 7 Things to Know about Complementary Health Approaches for

    Autism Spectrum Disorder

    40.18 4 Tips: Start Talking with Your Health Care Providers about

    Complementary Health Approaches

    40.19 7 Things to Know about Omega-3 Fatty Acids

    40.20 5 Tips: Natural Products Used for Common Aging-Related

    Conditions

    40.21 6 Things You Should Know about Dietary Supplements for

    Osteoarthritis

    40.22 7 Tips: Know the Facts about Supplements Marketed for Weight

    Loss

    40.23 5 Things to Know about Sleep Disorders and Complementary

    Health Approaches

    40.24 6 Things to Know about Complementary Health Approaches for

    Seasonal Affective Disorder

    40.25 5 Tips: What Consumers Need to Know about Dietary Supplements

    40.26 5 Things to Know about St. John’s Wort and Depression

    40.27 6 Things to Know about Massage Therapy for Health Purposes

    40.28 7 Things to Know about Complementary Health Approaches for

    ADHD

    40.29 6 Things to Know about Type 2 Diabetes and Dietary Supplements

    40.30 5 Tips: What You Should Know about Complementary Health

    Approaches for BPH

    40.31 8 Things to Know about Mind and Body Approaches for Health

    Problems Facing Military Personnel and Veterans

    40.32 5 Tips: What You Should Know about Tai Chi for Health

    40.33 6 Things to Know about Complementary Health Approaches for

    Seasonal Allergy Relief

    40.34 7 Tips: What You Should Know about Complementary Health

    Approaches for Multiple Sclerosis

    40.35 7 Things to Know about Complementary Health Approaches for

    Anxiety

    40.36 6 Tips: What You Need to Know about Complementary Health

    Approaches for Skin Conditions

    40.37 5 Things to Know about Complementary Health Approaches for

    Parkinson’s Disease

    40.38 5 Myths about Popular Natural Products Marketed for Disease

    Prevention and Wellness

    40.39 7 Things to Know about Mind and Body Practices for Children

    and Teens

    40.40 6 Things to Know about Travel-Related Ailments and

    Complementary Health Approaches

    40.41 6 Tips: IBS and Complementary Health Practices

    40.42 5 Things You Should Know about Dietary Supplements for

    Hepatitis C

    40.43 5 Things to Know about Probiotics

    40.44 5 Things to Know about Mind and Body Approaches for

    Substance Use Disorders

    40.45 4 Things to Know about Menopausal Symptoms and

    Complementary Health Practices

    40.46 6 Things to Know When Selecting a Complementary Health

    Practitioner

    40.47 5 Tips: What You Should Know about Popular Herbs

    40.48 8 Things to Know about Meditation for Health

    40.49 6 Things to Know about Complementary Health Approaches for

    Quitting Smoking

    40.50 5 Tips: What You Should Know about High Blood Cholesterol

    40.51 8 Things to Know about Depression and Complementary Health

    Approaches

    40.52 10 Things to Know about Dietary Supplements for Children and

    Teens

    40.53 4 Things To Know About Menopausal Symptoms and

    Complementary Health Practices

    40.54 Ayurvedic Medicine: In Depth

    40.55 Terms Related to Complementary and Integrative Health

    41. Skin Conditions and Complementary Health Approaches: What the

    Science Says

    National Institutes of Health

    41.1 Atopic Dermatitis

    41.2 Psoriasis

    41.3 Acne

    41.4 Impetigo

    41.5 Rosacea

    42. Nutrition and Health across the Lifespan: Guidelines and

    Recommendations

    U.S. Department of Agriculture

    42.1 Guideline 1: Follow a Healthy Dietary Pattern at Every Life Stage

    42.2 Guideline 2: Customize and Enjoy Food and Beverage Choices

    to Reflect Personal Preferences, Cultural Traditions, and

    Budgetary Considerations

    42.3 Guideline 3: Focus on Meeting Food Group Needs With

    Nutrient-Dense Foods and Beverages, and Stay Within Calorie

    Limits

    42.4 Guideline 4: Limit Foods and Beverages Higher in Added Sugars,

    Saturated Fat, and Sodium, and Limit Alcoholic Beverages

    42.5 Support Healthy Dietary Patterns for All Americans

    43. Using Dietary Supplements Wisely

    National Institutes of Health

    43.1 What’s the Bottom Line?

    43.2 What Are Dietary Supplements?

    43.3 What Are Herbal Supplements?

    43.4 Dietary Supplement Use in the United States

    43.5 Federal Regulation of Dietary Supplements

    43.6 What the Science Says about the Effectiveness of Dietary

    Supplements

    43.7 What the Science Says about the Safety and Side Effects of

    Dietary Supplements

    43.8 Safety Considerations

    44. Association of Genetic Liability to Smoking Initiation with e-Cigarette

    Use in Young Adults: A Cohort Study

    44.1 Introduction

    44.2 Results

    44.3 Discussion

    45. Current Issues in Vaccine Development

    45.1 Vaccine Development: An Introductory Overview

    45.2 How Vaccines Work

    45.3 Vaccine Development

    45.4 Improving Vaccine R&D

    45.5 Technologies and Approaches for Vaccine R&D

    45.6 Addressing Challenges Related to Vaccine R&D: Policy Options

    45.7 Technologies and Approaches That May Enhance Vaccine Testing

    45.8 Challenges Related to Vaccine Testing: Policy Options

    45.9 Technologies and Approaches for Vaccine Manufacturing

    45.10 Challenges Related to Vaccine Manufacturing: Policy Options

    45.11 Vaccine Development: Economics and Role of Incentives

    45.12 Economic Challenges to Vaccine Development: Policy Options

    46. Cannabis Products Containing Delta-8 Tetrahydrocannabinol:

    Increased Availability and Reports of Adverse Events

    Centers for Disease Control and Prevention

    46.1 Introduction

    46.2 Background

    46.3 Recommendations for the Public and Consumers

    46.4 Recommendations for Public Health Departments and Poison

    Control Centers, Including Those in Locations Where Laws Only

    Permit Hemp Marketplaces

    46.5 Recommendations for Retailers Selling Cannabis Products 1013

    46.6 Recommendations for Healthcare Providers

    46.7 For More Information

    47. Natural Doesn’t Necessarily Mean Safer, or Better

    National Institutes of Health

    48. How Medications and Supplements Can Interact

    National Institutes of Health

    48.1 Test Your Knowledge: Are These Statements True or False?

    48.2 Talk With Your Health Care Providers

    48.3 Some Supplements May Increase the Effects—and Side

    Effects—of Drugs

    48.4 Some Supplements May Decrease the Effects of Drugs

    48.5 More about St. John’s Wort

    48.6 Interactions with Over-the-Counter Drugs

    48.7 When Drug-Supplement Interactions Are Especially Important

    48.8 Drugs with a Narrow Therapeutic Range

    48.9 If You’re Going to Have Surgery

    48.10 Tips on Reading Supplement Labels

    48.11 Here’s a Hint for Your Next Visit to a Health Care Provider

    49. Antioxidants: Current Issues and Future Trends

    National Institutes of Health

    49.1 Introduction

    49.2 Key Points

    49.3 About Free Radicals, Oxidative Stress, and Antioxidants

    49.4 Use of Antioxidant Supplements in the United States

    49.5 Safety

    49.6 What the Science Says

    49.7 If You Are Considering Antioxidant Supplements

    49.8 NCCIH- and NIH-Funded Research

    49.9 For More Information

    50. Hearing Loss and Hearing Aids: Current Issues

    50.1 What Is Hearing Loss?

    50.2 What Noises Cause Hearing Loss?

    50.3 How Does Loud Noise Cause Hearing Loss?

    50.4 What Is Noise-Induced Hearing Loss?

    50.5 How Can I Tell If I Have a Hearing Problem?

    50.6 Who Can I Turn to for Help with My Hearing Loss?

    50.7 Why Am I Losing My Hearing?

    50.8 What Is an Audiogram?

    50.9 What Treatments and Devices Can Help?

    50.10 Hearing Aids: More Details

    50.11 What Are Some Features for Hearing Aids?

    50.12 Hearing Aids and How They Work

    50.13 Are There Different Styles of Hearing Aids?

    50.14 Are New Types of Aids Available?

    50.15 What Is the Difference between Analog and Digital Hearing Aids?

    50.16 Which Hearing Aid Will Work Best for Me?

    50.17 How Do I Get a Hearing Evaluation before Getting Hearing Aids?

    50.18 What Is the Difference between Prescription and Over-the

    Counter Hearing Aids?

    50.19 Who Are OTC Hearing Aids for?

    50.20 What Questions Should I Ask before Buying a Hearing Aid?

    50.21 How Can I Adjust to My Hearing Aid?

    50.22 How Can I Care for My Hearing Aid? 1075

    50.23 Can I Obtain Financial Assistance for a Hearing Aid?

    50.24 Hearing Aids vs. Personal Sound Amplification Products

    51. Bacterial Evolution during Human Infection: Adapt and Live or Adapt

    and Die

    51.1 Introduction

    51.2 Conclusions

    52. Roadblocks in Chagas Disease Care in Endemic and Nonendemic

    Countries: Argentina, Colombia, Spain, and the United States.

    The NET-Heart Project

    52.1 Introduction

    52.2 Methods

    52.3 Results

    52.4 Discussion

    52.5 Conclusions

    53. Pathogens Infecting the Central Nervous System

    54. Current Issues in Vaccines

    Centers for Disease Control and Prevention

    54.1 History of Vaccines

    54.2 Common Ingredients in U.S. Licensed Vaccines

    54.3 Understanding the Vaccine Adverse Event Reporting System

    54.4 Science Summary: CDC Studies on Thimerosal in Vaccines

    54.5 Pregnancy and Vaccination

    54.6 Understanding Thimerosal, Mercury, and Vaccine Safety

    54.7 2022 Recommended Immunizations for Children from Birth

    through 6 Years Old

    54.8 2022 Recommended Immunizations for Children 7–18 Years

    54.9 Recommended Adult Immunization Schedule for Ages 19 Years

    or Older

    55. What Are Embryonic Stem Cells and How Can They Help Us?

    55.1 It All Begins in Fertilization, When the Sperm Meets the Egg

    55.2 Cloning

    55.3 Therapeutic Cloning

    55.4 Reprogramming

    55.5 Therapy?

    55.6 Addendum by the Series Editor, Dr. Raj Bawa: The Future of

    Embryonic Stem Cells

    56. The Rise and Rise of Mitochondrial DNA Mutations

    56.1 Evolutionary Aspects of Mitochondrial Genetics

    56.2 Clonal Expansion of mtDNA Mutations

    56.3 Population Dynamics of mtDNA Point Mutations

    56.4 Population Dynamics of mtDNA Deletions

    56.5 Important Challenges and Unanswered Questions

    56.6 Modelling Clonal Expansion

    56.7 Conclusion and Future Perspectives

    57. Hallmarks of Cancer—the New Testament

    57.1 A Historical Perspective on Cancer

    57.2 Hallmarks of Cancer

    57.3 New Hallmark 1: Dedifferentiation and Transdifferentiation

    57.4 New Hallmark 2: Epigenetic Dysregulation

    57.5 New Hallmark 3: Altered Microbiome

    57.6 New Hallmark 4: Altered Neuronal Signalling

    57.7 Conclusion

    58. Adipose Tissue in Health and Disease

    58.1 Introduction

    58.2 Adipose Tissue Expansion and Development

    58.3 Inflammation

    58.4 Location of Lipid Storage

    58.5 Adipose Tissue Lipolysis and Insulin Resistance

    58.6 Endocrine Functions within Adipose Tissue

    58.7 Emerging Approaches to Combat Adipose Tissue-Derived

    Metabolic Dysfunction

    58.8 Concluding Remarks

    59. Viral Pathogenesis of SARS-CoV-2 Infection and Male Reproductive

    Health

    59.1 Introduction

    59.2 SARS-CoV-2: History, Origin and Transmission

    59.3 Possible Mechanism of SARS-CoV-2 Invasion into Host Cells and

    Immune Pattern of Infection

    59.4 Effect on the Male Reproductive System

    59.5 SARS-CoV-2 and Male Fertility

    59.6 Gender-Based Susceptibility

    59.7 Conclusion

    59.8 Future Perspectives

    60. Elevated CO2 Modulates Airway Contractility

    60.1 Introduction

    60.2 Hypercapnia-Induced Bronchoconstriction

    60.3 Respiratory Acidosis-Related Bronchodilation

    60.4 Effect of Hypocapnia on Airway Contractility

    60.5 Conclusion

    Index

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