Search results for ""taylor francis inc""

There is increasing evidence that even minute amounts of trace elements can have profound effects on the human body. Advances in Isotope Methods for the Analysis of Trace Elements in Man describes new methods that are being developed to understand normal and abnormal trace element nutrition and metabolism. This book includes a wealth of practical advice, encompassing all aspects of isotope methodology, such as the latest developments of analysis techniques for both stable and radioactive isotopes, issues in study design, current cost of isotopes, and analysis. It provides both a historical review of what has been done in the past and details of current techniques and applications. > This state-of-the-art collection from leading experts in the field from Europe and the United States makes a strong case for the practice and advancement of this critical health care tool.

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The Manual of Immunological Methods represents the collaboration of the Canadian Network of Toxicology Centers, a non-profit network of university-based scientists dedicated to research, training, risk assessment, and communication. This manual provides detailed immunological methods that can be utilized by researchers or practitioners who want to enhance the successful application of this science. It emphasizes the need for continuously improving the quality of experiments performed and maintaining consistency in the results obtained.The Manual of Immunological Methods presents validated assays that are accompanied by a series of tools that will guide readers in performing their own laboratory work in the spirit of the Good Laboratory Practices. It covers specific methodologies including sample collection, preparation of cells, assay conditions, and data evaluation. Discussion of species differences and comparisons of a wide variety of species is an important feature. Both graduate students and practicing researchers in the areas of immunology and immunotoxicology will appreciate the Manual of Immunological Methods as a guide to standard operating procedures in the laboratory.

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Extensively using experimental and numerical illustrations, CombustionPhenomena: Selected Mechanisms of Flame Formation, Propagation, and Extinction provides a comprehensive survey of the fundamental processes of flame formation, propagation, and extinction.Taking you through the stages of combustion, leading experts visually display, mathematically explain, and clearly theorize on important physical topics of combustion. After a historical introduction to the field, they discuss combustion chemistry, flammability limits, and spark ignition. They also study counterflow twin-flame configuration, flame in a vortex core, the propagation characteristics of edge flames, instabilities, and tulip flames. In addition, the book describes flame extinction in narrow channels, global quenching of premixed flames by turbulence, counterflow premixed flame extinction limits, the interaction of flames with fluids in rotating vessels, and turbulent flames. The final chapter explores diffusion flames as well as combustion in spark- and compression-ignition engines. It also examines the transition from deflagration to detonation, along with the detonation wave structure. With downloadable resources of images that beautifully illustrate a range of combustion phenomena, this book facilitates a practical understanding of the processes occurring in the conception, spread, and extinguishment of a flame. It will help you on your way to finding solutions to real issues encountered in transportation, power generation, industrial processes, chemical engineering, and fire and explosion hazards.

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The formal description of non-precise data before their statistical analysis is, except for error models and interval arithmetic, a relatively young topic. Fuzziness is described in the theory of fuzzy sets but only a few papers on statistical inference for non-precise data exist. In many cases, for example when very small concentrations are being measured, it is necessary to describe the imprecision of data. Otherwise, the results of statistical analysis can be unrealistic and misleading. Fortunately, there is a straightforward technique for dealing with non-precise data. The technique - the generalized inference method - is explained in Statistical Methods for Non-Precise Data. Anyone who understands elementary statistical methods and simple stochastic models will be able to use this book to understand and work with non-precise data.The book includes explanations of how to cope with non-precise data in different practical situations, and makes an excellent graduate level text book for students, as well as a general reference for scientists and practitioners.Features

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Access Device Fraud and Related Financial Crimes offers front-line exposure. It is a reference text that affords the student, financial investigator or law enforcement professional a true insight into a wide spectrum of criminal activity involving financial crimes. This book brings the reader back to the scene of cases in which the intensity and ma

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The field of public administration currently lacks sufficient resources for understanding the rationale, implications, and inherent practices of reforming government administration around the world.The Handbook of Administrative Reform satisfies this need by bringing together diverse international experts to analyze the sensible processes and intervention strategies central to administrative reform in nine nations geographically located in North America, Europe, and Latin America.Organized into five related parts, the text begins by examining factors that influence administrative reform—most notably, pressure to adhere to the institutional, international, and supranational standards promulgated by globalization, the European Union, and the United Nations. Subsequent sections further support this hypothesis by delving into specific case studies of founding and early EU members, new EU members, and EU applicant nations. After a thorough exploration of North America and Latin America, the volume concludes with a challenge to public administrators around the globe to continue the noble cause of advancing democracy through accountable, transparent, and responsive reform.

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The integration of microelectromechanical systems (MEMS) and nanotechnology (NT) in sensors and devices significantly reduces their weight, size, power consumption, and production costs. These sensors and devices can then play greater roles in defense operations, wireless communication, the diagnosis and treatment of disease, and many more applications.MEMS and Nanotechnology-Based Sensors and Devices for Communications, Medical and Aerospace Applications presents the latest performance parameters and experimental data of state-of-the-art sensors and devices. It describes packaging details, materials and their properties, and fabrication requirements vital for design, development, and testing. Some of the cutting-edge materials covered include quantum dots, nanoparticles, photonic crystals, and carbon nanotubes (CNTs). This comprehensive work encompasses various types of MEMS- and NT-based sensors and devices, such as micropumps, accelerometers, photonic bandgap devices, acoustic sensors, CNT-based transistors, photovoltaic cells, and smart sensors. It also discusses how these sensors and devices are used in a number of applications, including weapons’ health, battlefield monitoring, cancer research, stealth technology, chemical detection, and drug delivery.

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Focusing on a public health problem affecting millions of people of all ages, the second edition of Concussive Brain Trauma: Neurobehavioral Impairment and Maladaptation reflects Dr. Rolland S. Parker's more than 25 years of neuropsychological practice and research in traumatic brain injury and stress, and his prior experience as a clinical psychologist. Unique in its coverage of the personality changes, family dysfunction, and stress that often occur in the wake of concussive brain trauma, this book uses case examples to illustrate persistent and acute alterations of consciousness, as well as cognitive, mood, personality, and social effects of head injury in order to guide appropriate treatment. With six additional chapters, this edition covers: Post-concussive syndrome, biomechanical causes of trauma, and acute and chronic phases of co-morbid brain and somatic injury The physiological basis for behavior and posttraumatic dysregulation of systems Disorders related to pain, sensation, and motor activities Headaches, consciousness, cognition, cerebral personality, and psychodynamic disorders Developmental effects of children's concussive injury Blast injuries characteristic of modern war Unfamiliar signs not included in the usual list of post-concussive symptoms With a firm multi-disciplinary foundation, this book aids the concerned practitioner in rendering a more complete and accurate assessment, recognizing gaps in prior documentation, and conducting a more complete examination to acquire omitted information. It also shows how to achieve the benefit of higher accuracy in assessing disability, planning rehabilitation, and offering compensation. The book stands alone as an in-depth, authoritative guide to closed head injury and traumatic brain injury.

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In the 40 years since the classic review of osmotic and ionic regulation written by Potts and Parry, there has been astonishing growth in scientific productivity, a marked shift in the direction and taxonomic distribution of research, and amazing changes in the technology of scientific research"…It is indicative of the growth of the subject that as time passes the number of authors needed to review the subject grows exponentially. The time is ripe for a new survey of the subject and Dr. Evans is to be congratulated on the expert crew that he has recruited."—From the foreword by W.T.W. PottsOsmotic and Ionic Regulation: Cells and Animals not only fills a gap in the literature, but delineates the new approaches, outlooks, and findings that define how the field has changed. Providing the first comprehensive summary of the fundamentally important mechanisms of ionic and osmotic regulation in 40 years, it ties the new findings to the older work of Potts and Parry.This book, written by accepted leaders in this field dealing with the ecology to the molecular biology of the processes and the taxa, provides background information in a broad range of disciplines such as zoology, evolutionary biology, physiology, ichthyology, aquaculture, marine biology, entomology, herpetology, avian biology, human nephrology, conservation biology, and pharmacology.

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When enjoying a southeast asian soup or cup of herbal tea, we are really savoring the flavor of lemongrass. Similarly, the sweet aroma of mosquito-repelling lotions comes from the citronella oil present in them. Fine perfumes, candles, and herbal pillows with the pleasing smell of rose are often in fact scented with palmarosa. Providing an in-depth look at their history and production, Essential Oil Bearing Grasses: The genus Cymbopogon provides a comprehensive review of these economically important grasses. A detailed examination of chemical constituents and market trends, the book explores the cosmetic, medicinal, and nutritional uses of the plant. It covers the botany, taxonomy, chemistry, and biogenesis of the oils, and their extraction and analytical methods, biotechnology, storage, legislation, and trade. Highlighting industrial uses for the grasses in this genus, the book also includes coverage of the physiological and ecophysiological considerations. It presents a comprehensive overview of most of the cultivated and wild species of cymbopogons.Featuring contributions from a team of international experts, the book describes the considerable ethno-botanical, phytochemical, and pharmacological knowledge associated with the multidimensional uses of the oils. It provides a complete industrial profile that includes market size, geographical sources, export and import data, and industry uses. Its pages offer an invaluable resource for research, cultivation, marketing, or product development of Cymbopogon.

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Deterministic Learning Theory for Identification, Recognition, and Control presents a unified conceptual framework for knowledge acquisition, representation, and knowledge utilization in uncertain dynamic environments. It provides systematic design approaches for identification, recognition, and control of linear uncertain systems. Unlike many books currently available that focus on statistical principles, this book stresses learning through closed-loop neural control, effective representation and recognition of temporal patterns in a deterministic way. A Deterministic View of Learning in Dynamic EnvironmentsThe authors begin with an introduction to the concepts of deterministic learning theory, followed by a discussion of the persistent excitation property of RBF networks. They describe the elements of deterministic learning, and address dynamical pattern recognition and pattern-based control processes. The results are applicable to areas such as detection and isolation of oscillation faults, ECG/EEG pattern recognition, robot learning and control, and security analysis and control of power systems. A New Model of Information ProcessingThis book elucidates a learning theory which is developed using concepts and tools from the discipline of systems and control. Fundamental knowledge about system dynamics is obtained from dynamical processes, and is then utilized to achieve rapid recognition of dynamical patterns and pattern-based closed-loop control via the so-called internal and dynamical matching of system dynamics. This actually represents a new model of information processing, i.e. a model of dynamical parallel distributed processing (DPDP).

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Nanomedical Device and Systems Design: Challenges, Possibilities, Visions serves as a preliminary guide toward the inspiration of specific investigative pathways that may lead to meaningful discourse and significant advances in nanomedicine/nanotechnology. This volume considers the potential of future innovations that will involve nanomedical devices and systems. It endeavors to explore remarkable possibilities spanning medical diagnostics, therapeutics, and other advancements that may be enabled within this discipline. In particular, this book investigates just how nanomedical diagnostic and therapeutic devices and systems might ultimately be designed and engineered to accurately diagnose and eradicate pathogens, toxins, and myriad disease states.This text utilizes an author conceptualized exemplar nanodevice and system, the Vascular Cartographic Scanning Nanodevice (VCSN), to explore various prospective design considerations that might facilitate and enable selected functionalities of advanced autonomous nanomedical devices. It showcases a diverse group of expert contributing authors, who describe actual laboratory-based research aimed at the advancement of nanomedical capabilities. It also articulates more highly conceptual nanomedical possibilities and visions relating to the implementation of nanomedical technologies in remote regions and the developing world, as well as nanomedicine in space applications, human augmentation, and longevity. Investigates nanomedical diagnostic and therapeutic strategies that might be applied in remote regions and the developing world Discusses how nanomedicine might be utilized in space applications, inclusive of spacesuits, spacecraft, future human habitats on the Moon and Mars, and deep space Covers how nanomedicine may be implemented in selected forms of human augmentation and toward the potentially radical extension of the human life span This book benefits undergraduate and graduate students who are studying nanotechnology/nanomedicine, as well as medical administrative, scientific research, and manufacturing professionals in this industry.

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Alternating the focus of the series each year, the new volume in the Ion Exchange and Solvent Extraction series represents the vanguard of research in ion exchange. Ion Exchange and Solvent Extraction: A Series of Advances, Volume 18 reflects the remarkable breadth of applications inspiring the latest advances, featuring carefully selected contributors in areas including catalysis, molecular imprinting, drug delivery, nanotechnology, green processes, water treatment, and pollution control.The book explores the properties of resins, synthetic polymers, and naturally occurring materials that exhibit ion exchange properties. It explains their role in synthesis reactions with experimental evidence, examples of reactions, and models. The book also provides useful data, calculations, modeling approaches, process variables, and design aspects to consider for a variety of novel applications. Ion Exchange and Solvent Extraction: A Series of Advances, Volume 18 offers an updated perspective on the current and potential capabilities of ion exchange materials in today's most cutting-edge applications.

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Understanding the energy it takes to build or break chemical bonds is essential for scientists and engineers in a wide range of innovative fields, including catalysis, nanomaterials, bioengineering, environmental chemistry, and space science. Reflecting the frequent additions and updates of bond dissociation energy (BDE) data throughout the literature, the Comprehensive Handbook of Chemical Bond Energies compiles the most recent experimental BDE data for more than 19,600 bonds of 102 elements. The author organizes the data by bond type, functional group, bond order, bond degree, molecular size, and structure for ease of use. Data can also be located using the Periodic table. The book presents data for organic molecules, biochemicals, and radicals as well as clusters, ions, hydrogen- and surface-bonded species, van der Waals complexes, isotopic species, and halogen-clusters/complexes. It also introduces entirely new data for inorganics and organometallics. The final chapter summarizes the heats of formation for atoms, inorganic/organic radicals, and monoatomic ions in the gas phase.The Comprehensive Handbook of Chemical Bond Energies offers quick access to experimental BDE data in the most inclusive, well-organized, and up-to-date collection available today.

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In the twenty-first century, we are just beginning to understand more clearly the enormous diversity and complexity of signaling processes in the retina. Integrating advances in the biochemistry, cell biology, physiology, and physics of phototransduction, Signal Transduction in the Retina presents the methodologies and experimental approaches that yield key information on the mechanisms underlying normal retinal physiology. This in-depth work discusses the latest techniques and applications for understanding retinal function and degradation, developing novel therapeutic strategies, and promoting cellular survival and functional retention.Drawing contributions from experts in a range of disciplines, each chapter presents a brief overview of the area discussed along with specific methodology for obtaining the primary data to understand the cellular and molecular process. Given the dominance and wealth of information on rhodopsin-based phototransduction, the book devotes substantial attention to this topic, but also evaluates a diversity of signaling mechanisms. Beginning with the molecular mechanisms of vertebrate phototransduction, this volume presents the structure of phototransduction cascade components at atomic resolution, as well as molecular interactions in multi-protein complexes and novel cell-based strategies for understanding signal shut-off and light adaptation. It discusses non-visual phototransduction and the role of melanopsin in adaptive photoresponses and circadian clock regulation. The book also compares the visual signaling processes of vertebrates and invertebrates. It examines experimental studies of insulin-based signaling in the inner and outer retina; investigates retinal development including signaling in progenitor cells, cell-cell communication in developing cells, and neovascularization; and studies lipid-derived mediators such as neuroprotectins and discusses the participation of retinal pigment epithelium in neuronal survival.

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Culled from the pages of CRC's highly successful, best-selling The Circuits and Filters Handbook, Second Edition, Passive, Active, and Digital Filters presents a sharply focused, comprehensive review of the fundamental theory behind professional applications of these complex filters. It supplies a concise, convenient reference to the key concepts, models, and equations necessary to analyze, design, and predict the behavior of large-scale systems that employ various types of filters, illustrated by frequent examples. Edited by a distinguished authority, this book emphasizes the theoretical concepts underlying the processes, behavior, and operation of these filters. More than 470 figures and tables illustrate the concepts, and where necessary, the theories, principles, and mathematics of some subjects are reviewed. Expert contributors discuss general characteristics of filters, frequency transformations, sensitivity and selectivity, low-gain active filters, higher-order filters, continuous-time integrated filters, FIR and IIR filters, and VLSI implementation of digital filters, among many other topics.Passive, Active, and Digital Filters builds a strong theoretical foundation for the design and analysis of a variety of filters, from passive to active to digital, while serving as a handy reference for experienced engineers, making it a must-have for both beginners and seasoned experts.

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A Single Source on Parallel Synthesis for Lead OptimizationThe end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening. Over time, it became clear that more thought in the design phase of library development is necessary to generate high quality hits. More recently, the use of parallel synthesis techniques has shifted to applications beyond screening collections. Exploring the nuances of this technology, High-Throughput Lead Optimization in Drug Discovery describes the application of parallel synthesis to lead optimization and the design and synthesis of targeted libraries. Examine Case Studies that Cover a Range of Different Biological Targets Featuring real-world examples and contributions from well-known scientists, the book explores the shift to conducting parallel lead optimization in-house while outsourcing most of the screening libraries synthesis. It includes more than 15 case studies that encompass a range of biological targets for application in different therapeutic areas. The text contains examples of solid and solution-phase techniques for the synthesis of directed libraries. The chapter authors explain the design principles they used to direct the choice of templates and diversity elements. Speed Up Drug Discovery and the Hit-to-Lead Process Focusing on the application of combinatorial chemistry to medicinal chemistry, this volume compiles a series of optimization projects that give you a snapshot of successes and challenges in the use of parallel synthesis for lead optimization. It explores how this technology, when applied to library design, can speed up drug discovery.

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Drawing on the author’s extensive personal experience, Medicinal Plants of Asia and the Pacific provides comprehensive coverage of the medicinal plants of the region. Describing more than 300 compounds, the book discusses every important class of natural products while highlighting cutting-edge research and recent developments. With its broad scope and extensive compound listings, the presentation and approach of the book is completely original.

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The first text designed specifically with clinical practitioners in mind, Functional Neuroimaging demonstrates the clinical application and utilization of functional neuroradiology for early diagnosis, neurological decision-making, and assessing response to cancer therapy. Edited by the Founding President of American Society of Functional Neuroradiology, this guide expertly describes the incorporation of this technology into clinical practice and showcases high-quality color images depicting the function and mechanisms of the brain.Features: Helps clinicians incorporate functional neuroradiology into their practice Shows new advancements in functional brain imaging to benefit the diagnosis, management, and treatment of patients Depicts current methods for imaging the central nervous system, as well as cutting-edge approaches for the imaging of brain function Contains 320 intricate, full-color figures comprising the anatomy and function of the brain Neuroradiologists, radiologists, neurologists, neurosurgeons, and clinical psychologists will find this an essential guide to enhance the quality of their practice.

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The past 20 years can be regarded as the adolescence of geographic information science (GIS), as it grew from a burgeoning area of study into a mature and thriving field. During those two decades, the International Journal of Geographic Information Science (formerly Systems) (IJGIS) was one of the most prominent academic guiding forces in GIScience, and looks to remain so for the foreseeable future. To celebrate this important milestone, Peter Fisher-the second editor of IJGIS-has compiled 19 of the most significant and influential articles ever published in the journal.Classics from IJGIS: Twenty Years of the International Journal of Geographical Information Science and Systems contains articles that shaped the way we approach the science of GIS, provided seeds from which grew key developments that have molded the field, opened new avenues of discovery across the landscape of modern GIScience, and some that may mark how it will change in the future. Accompanying nearly every article is a commentary written by at least one of the original authors. In these commentaries, the authors reflect on various aspects of the original work, including what drove their original research, why the concepts were widely adopted (or in some cases, why not), and what the future may hold for new research embarking on these and similar areas. The 20th article in this collection is an original contribution that examines the social and collaborative networks operating within and shaping the body of research in the field.

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Fibrinolysis in Disease reviews the state of the art of basic and clinical aspects of the fibrinolytic enzyme system. The text, authored by outstanding and internationally known investigators, is presented in two books.The Malignant Process, Interventions in Thrombogenic Mechanisms, and Novel Treatment Modalities discusses the molecular biology of the system's key components and their fundamental roles in a variety of thrombotic and metabolic disorders. Molecular and Hemovascular Aspects of Fybrinolysis presents the latest findings and concepts of the association between plasminogen activator (u-PA) overexpression and abnormal growth regulation in a variety of solid tumors and in leukemia. One chapter deals with various successful interventions in thrombogenic mechanisms, ranging from exercise and diet to anticoagulants and direct and indirect thrombolytic agents. It concludes with a projection of exciting, novel treatment modalities in thrombotic and malignant diseases.

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This volume provides a synthesis of recent work on evolutionary aspects of metal tolerance in plants. It presents contributions from scientists with a wide diversity of expertise. It covers the evolution of heavy metal tolerance in groups of plants, fungi, and protists. The book discusses the physiological, genetic and molecular aspects of metal tolerances. It deals with the evolution of populations in metal-contaminated environments. Several chapters include tolerance in animals in order to place the rest of the book on plants in proper perspective. This publication is an exciting addition for scientists with both applied and basic interest in metal toxicity and tolerance. It is of importance to those in vegetation ecology, land reclamation, agronomy, physiology, population ecology, ecological genetics, evolutionary biology and molecular biology.

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Cell Surface Carbohydrates and Cell Development summarizes knowledge on the structure and function of cell surface carbohydrates in development and differentiation. The chapters include reviews on the expression of cell type-specific carbohydrates and their roles in cell-cell interaction. In particular, the role of cell surface carbohydrates in immune cell response, malignant transformation, fertilization, and neural cell development are addressed. This includes the exciting discovery about the role of adhesive molecules in leukocyte-endothellium interaction.Cell Surface Carbohydrates and Cell Development also summarizes the latest knowledge on structure and biosynthesis of carbohydrates, the role of specific carbohydrate modification, and animal lectins. The book will be useful to researchers and students interested in the biology of glycoproteins and biotechnology.

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Hormones and Vitamins in Cancer Treatment is intended to serve as a therapeuticial guide for physicians using non-aggressive methods, such as hormonotherapy and vitamin therapy, when treating cancer patients. This book provides the rationale and scientific basis for hormones and vitamins, which play an important role in cancer management, and emphasizes the significance of hormones and vitamins in chemoprevention and chemoprophylaxis of cancer. Topics discussed in this book include the criteria for selecting patients for hormonotherapy and vitamin therapy; the favorable effects and advantages of hormonotherapy and vitamin therapy over (or used as adjuvant therapeutic agents) more aggressive methods, such as chemotherapy, radiation therapy, immunotherapy or surgery; and hormone-like substances, such as growth factors, interferons, interleukins, and prostoglandins. Also included is the newest information regarding the role of diet in cancer prevention. This book is packed with valuable information for researchers, physicians, and students of endrocrinology and clinical oncology. It is also the only book of its kind that discusses the role of hormones, hormone-like substances, and vitamins in cancer prevention and treatment.

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A concise, in-depth analysis of the status of the sympathetic system in heart diseasesThis book summarizes the functional status of the sympathetic neural system in cardiological diseased states and highlights aspects of sympathetic neural activity that are important to an overall understanding of the pathophysiology process. Critical reviews of methods for evaluating sympathetic activity are discussed, existing data is closely scrutinized, and attempts are made to delineate the factors derived from increased sympathetic activity. The book provides a physiologically and clinically based approach to the investigation of the involvement of catecholamines in cardiovascular diseases, which makes it a valuable addition to the reference collections of researchers, clinical scientists, and graduate students.

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Biology and Physiology of the Osteoclast is a comprehensive volume thoroughly covering the field of osteoclast biology. The book features some of the latest work (much of which has never before been published) from internationally respected scientists in the field. It will be a significant reference volume for researchers interested in the broad field of bone metabolism, especially those in cell and molecular biology, dental science, endocrinology, hematology, orthopedics, and rheumatology.

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This volume presents information regarding the mechanisms of protein absorption under normal and pathologic conditions, in addition to reviewing changes that occur at various stages of life. General modifiers of intestinal absorption, such as the processing of foods, the nutritional status of the individual, and disease, are explored with reference to both proteins and minerals. Inorganic macronutrients, namely calcium, magnesium and phosphorus, are discussed in relation to protein ingestion. The book also explores the concept of essential trace elements (e.g., iron, zinc, copper, and iodine) and their link to protein sufficiency. The relationship of ultratrace elements with the content of proteins in food is examined, and the book offers a fresh view of the role of certain elements, particularly zinc, on the conformation of proteins linked to DNA, hormone receptors, and gene products. Protein Nutrition and Mineral Absorption is packed with 2,300 references, 100 figures and graphs, plus 25 tables. Nutritionists and physicians will find this book to be an invaluable reference source for rationalizing nutritional interventions and diet modifications for their patients.

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The Experimental Animal in Biomedical Research provides a concise, useful survey of knowledge regarding laboratory animal care. Volume I addresses researchers who use animals and focuses on how to maximize the welfare of animals used in research.

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This comprehensive publication draws together the important aspects of carcinogen-cell interaction. This interesting work describes the regulation of normal cell proliferation, cellular responses to carcinogen damage, the biologic consequences of cellular DNA modification, the structural and genomic changes resulting from carcinogen insult, and the possible involvement of such changes in the conversion of normal human fibroblasts to malignant cells. It presents current reviews with up-to-date literature references and provides critical information from leading investigators that is essential in understanding the biology of human cell transformation. This volume is especially useful to advanced students in genetic toxicology, molecular biologists, and all who are interested in the molecular and macromolecular changes in human cells leading to neoplasia.

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Pulse Radiolysis presents an in-depth discussion of the pulse radiolysis technique, one of the most important and powerful means for detecting transient and relaxation phenomena and following their behavior in irradiated systems. The book covers the principle of pulse radiolysis, identifies various kinds of pulse radiolysis techniques, and discusses recent advancements in the field. The text also discusses new experimental pulse radiolysis techniques (basic and applied) in broad scientific fields such as physics, chemistry, biology, and engineering. These techniques include picosecond pulse radiolysis, single particle radiolysis, and muon-induced transient phenomena. Pulse Radiolysis provides essential information for all professionals involved with pulse radiolysis research.

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The current technology and its applications in flow cytometry are presented in this comprehensive reference work. Described in explicit detail are the instrumentation and its components, and applications of the technology in cell biology, immunology, pharmacology, genetics, hematology and clinical medicine. Methods for data analysis, including both hardware and software, and explicit experimental techniques for making specific measurements are presented.Material is divided by topic into two volumes: Volume I covers instrumentation, genetics, and cell structure; Volume II contains material on cell function studies by flow cytometry.This reference is essential for both the novice and the experienced investigator using flow cytometry in research, and for students of cell biology, biomedical engineering, and medical technology.

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This two-volume handbook presents advanced research and operational information about hard minerals and hydrocarbons. It provides information in an integrated, interdisciplinary manner, stressing case histories. It includes review chapters, illustrations, graphs, tables, and color satellite images that present the results of gravity, geodetic, and seismic surveys and of 3-D sea floor sub-bottom visualizations. The data was obtained using satellites, aircraft, and ships from the Atlantic and Pacific Oceans, the Gulf of Mexico, and the Caribbean Sea. Major topics addressed in these volumes include geophysical methods used to explore for hydrocarbons, advanced radiometric and electrical methods for hard mineral searches, the role of geotechnology and seismic acoustics in overcoming geological hazards in selecting drilling sites and pipeline routes, and remote sensing techniques used to determine the physical properties of sediments.

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Providing an essential brainstem relay for three cranial nerves, the NST coordinates highly complex sensory information. While other functions of the NST have received attention, its role in gustatory processing has received little. The first reference devoted exclusively to gustatory processing, The Role of the Nucleus of the Solitary Tract in Gustatory Processing offers an in-depth review of one of the most important central relay stations in the brain.Combining widely dispersed research into a comprehensive single volume, it presents a thorough historical background, documents the anatomy of the rostral nucleus of the solitary tract (rNST), and explores the properties of synaptic transmitters and neurons within that tract. The book examines the role of reflex activities and considers factors that influence how gustatory rNST neurons respond to taste stimuli. It describes the development and maturational changes the rNST undergoes and considers the challenge involved with identifying rNST neural circuits.The Role of the Nucleus of the Solitary Tract in Gustatory Processing brings together expert investigators who have contributed substantially to the current knowledge of the anatomy, physiology, and developmental biology of the solitary nucleus. This pertinent work serves as a standard reference for those involved in the field, providing ready access to past investigations and inviting practitioners to create new approaches that will advance knowledge about the central processing of gustatory information.

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Preparative Layer Chromatography explains how this method is used for separating large quantities of mixtures containing a wide variety of important compounds. It offers a broad review of preparative layer chromatography (PLC) applications and adaptable working procedures for microseparations involving organic, inorganic, and organometallic compounds. The book contains theoretical background, chemical principles, and relevance of preparative layer chromatography (PLC) to a wide range of applications, particularly in the study of pharmaceuticals and biochemistry. Written by many of the best known and most knowledgeable specialists in the field, the chapters describe all the necessary techniques, current procedures, and superior strategies for selecting the most suitable eluents and designing application-specific PLC systems based on the data being sought. They provide comprehensive instructions, surrounding issues, and suggestions for optimizing optional working techniques within the framework of PLC. The book also provides a complete coverage of bulk sorbents and precoated chromatographic plates available on the international market. A comprehensive, yet accessible source of information, Preparative Layer Chromatography is a relevant and practical text for experienced as well as novice researchers and practitioners involved in analytical, environmental, geochemical, biological, medicinal, and pharmaceutical analysis.

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Volume 44, devoted solely to the vital research areas concerning the biogeochemistry of metals and their transport in the environment and availability to living systems, offers 9 timely and authoritative chapters on these fascinating topics by 19 internationally recognized experts.

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Unsupervised Signal Processing: Channel Equalization and Source Separation provides a unified, systematic, and synthetic presentation of the theory of unsupervised signal processing. Always maintaining the focus on a signal processing-oriented approach, this book describes how the subject has evolved and assumed a wider scope that covers several topics, from well-established blind equalization and source separation methods to novel approaches based on machine learning and bio-inspired algorithms.From the foundations of statistical and adaptive signal processing, the authors explore and elaborate on emerging tools, such as machine learning-based solutions and bio-inspired methods. With a fresh take on this exciting area of study, this book: Provides a solid background on the statistical characterization of signals and systems and on linear filtering theory Emphasizes the link between supervised and unsupervised processing from the perspective of linear prediction and constrained filtering theory Addresses key issues concerning equilibrium solutions and equivalence relationships in the context of unsupervised equalization criteria Provides a systematic presentation of source separation and independent component analysis Discusses some instigating connections between the filtering problem and computational intelligence approaches. Building on more than a decade of the authors’ work at DSPCom laboratory, this book applies a fresh conceptual treatment and mathematical formalism to important existing topics. The result is perhaps the first unified presentation of unsupervised signal processing techniques—one that addresses areas including digital filters, adaptive methods, and statistical signal processing. With its remarkable synthesis of the field, this book provides a new vision to stimulate progress and contribute to the advent of more useful, efficient, and friendly intelligent systems.

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The deep interconnection between micro/nanooptical components and related fabrication technologies—and the constant changes in this ever-evolving field—means that successful design depends on the engineer’s ability to accommodate cutting-edge theoretical developments in fabrication techniques and experimental realization.Documenting the state of the art in fabrication processes, Microoptics and Nanooptics Fabrication provides an up-to-date synopsis of recent breakthroughs in micro- and nanooptics that improve key developmental processes. This text elucidates the precise and miniaturized scale of today’s fabrication methods and their importance in creating new optical components to access the spectrum of physical optics. It details successful fabrication techniques and their direct effect on the intended performance of micro- and nanooptical components. The contributors explore the constraints related to material selection, component lateral extent, minimum feature size, and other issues that cause fabrication techniques to lag behind corresponding theory in the development process. Written with the professional optical engineer in mind, this book omits the already well-published broader processing fundamentals. Instead it focuses on key tricks of the trade helpful in reformulating processes to achieve necessary optical targets, improve process fidelity, and reduce production costs. The contributing authors represent the vanguard in micro-optical fabrication. The result of their combined efforts, this searing analysis of emerging fabrication technologies will continue to fuel the expansion of optics components, from the microwave to the infrared through the visible regime.

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Database of Biologically Active Phytochemicals and Their Activities presents an alphabetical tabulation of some 3,000 biologically active phytochemicals (elements and compounds) from higher plants. The data includes at least one and in some cases as many as 25 biological activities for each phytochemical. The database also provides data on effective dose, inhibitory concentrations, and lethal and/or toxic doses. Entries after 1990 indicate the source of the data. Database of Biologically Active Phytochemicals and Their Activities makes it possible to locate the concentration of many compounds in plants and compare this data with dosage information to calculate how much of a given plant food it would take to cause lethality, antioxidant activity, hypoglycemic activity, or artemicidal activity. Using WordPerfect™ 5.1's search function, you can find compounds by entering a key word in their name (e.g., choline or salicyl-), locate all compounds with a given activity (e.g., hypotensive), or list all compounds for which ED50 data is entered or reported.

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Code-division multiple access (CDMA) technology has been widely adopted in cell phones. Its astonishing success has led many to evaluate the promise of this technology for optical networks. This field has come to be known as Optical CDMA (OCDMA). Surveying the field from its infancy to the current state, Optical Code Division Multiple Access: Fundamentals and Applications offers the first comprehensive treatment of OCDMA from technology to systems.The book opens with a historical perspective, demonstrating the growth and development of the technologies that would eventually evolve into today's optical networks. Building on this background, the discussion moves to coherent and incoherent optical CDMA coding techniques and performance analysis of these codes in fiber optic transmission systems. Individual chapters provide detailed examinations of fiber Bragg grating (FBG) technology including theory, design, and applications; coherent OCDMA systems; and incoherent OCDMA systems. Turning to implementation, the book includes hybrid multiplexing techniques along with system examples and conversion techniques to connect networks that use different multiplexing platforms, state-of-the-art integration technologies, OCDMA network security issues, and OCDMA network architectures and applications, including a look at possible future directions.Featuring contributions from a team of international experts led by a pioneer in optical technology, Optical Code Division Multiple Access: Fundamentals and Applications places the concepts, techniques, and technologies in clear focus for anyone working to build next-generation optical networks.

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Sustainable management of water resources is quickly increasing in importance on a global scale. An important piece of the puzzle is the characterization of marine water and determining its importance to geochemical budgets. To do this, submarine groundwater discharges must be carefully studied. Comprehensively exploring the subject, Submarine Groundwater presents quantitative data relating groundwater contribution to the water/salt balance of regional and global bodies of water.The authors examine different data-supported methods for studying submarine groundwater flow and discharge through case studies contributed by leading international scientists. They discuss the maintenance of optimal water, salt, temperature and hydrobiological regimes of inland seas and large lakes. The book covers subsurface water exchange between the land and sea as well as groundwater discharge to the seas. It also provides a review of experimental methods and numerical modeling that can be used for the evaluation of specific discharge data and the effect of groundwater on the salt balance of seas and oceans. Defining the field of marine hydrogeology as a science that studies submarine groundwater, its properties, circulation, and distribution, Submarine Groundwater delineates the role of quantitative assessment of subsurface water exchange between land and sea in predicting its changes under the influence of natural factors and human activity. It provides a framework for assessing different methods and making the best choice for various situations.

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This authoritative volume contains 179 chapters by international experts on recent developments in our understanding of amyloid proteins, protein folding disorders, and new and proposed clinical trials in amyloidosis. Topics include detection and characterization techniques; biological functions; genetics; disorders, diagnosis, and treatments, including organ transplants and drug therapies; results from extensive clinical studies; and epidemiology. This is a valuable resource for clinicians who care for patients with systemic and localized forms of amyloidosis, and for researchers in biochemistry, neurobiology, and cell biology.

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This new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research.

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The field of materials science and engineering is rapidly evolving into a science of its own. While traditional literature in this area often concentrates primarily on property and structure, the Materials Processing Handbook provides a much needed examination from the materials processing perspective. This unique focus reflects the changing complexity of new and emerging materials such as cutting-edge semiconductors, smart materials, and materials based on spintronics.This highly comprehensive work also presents groundbreaking coverage of the processes applied to a myriad of solid materials including ceramics, polymers, metals, composites, and semiconductors. Organized into six sections, this work examines processes that convert one phase into another, processes that change only the microstructure within a solid phase, shape changes that modify the microstructure and properties of materials, joining processes, and the basics of processes integration.Rich in data, yet accessible across several fields, this volume provides technicians and students with a one-stop resource on proven and promising new developments in materials processing.

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Handbook of Behavioral State Control: Cellular and Molecular Mechanisms provides the first synthesis of information on the neurobiology of behavioral states, ranging from normal stress and sleep deprivation to debilitating neuropsychiatric disorders. This book presents a working reference on the cellular and molecular mechanisms generating arousal states; pharmacological and non-pharmacological methods of behavioral state control; and the bi-directional interaction between arousal state and the neurobiology of pain, and between sleep and the immune system.

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Providing a general approach to the understanding and management of all forms of chronic pain, this book offers a clear and reader-friendly format that clarifies procedures in the diagnosis, assessment, and treatment of the most common chronic non-cancer pain entities. Describing various types of intractable non-cancer pain, including neuropathic, somatic, and visceral pain, this source discusses the many available types of treatments, including opioid and adjunctive pain medications, and the safe and proper use of narcotics for treating chronic pain.

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At a time when much of humanity is already but one failed harvest removed from starvation, we cannot afford to ignore any potential danger to food security, especially when that danger poses a threat to rice, the staff of life for so much of the world. Crop Ferality and Volunteerism brings together research pioneers from various disciplines including the crop, plant, and weed sciences to discuss crop ferality and volunteerism. The book provides thorough coverage of crop and plant molecular biology and genetics as it pertains to ferality and weeds. In an exhaustive effort to provide complete and highly useful coverage of this impending crisis, the authors go beyond the science of the problem to discuss the potential economic and social impact of crop ferality, particularly in relationship to rice. Readers will discover a wealth of well-organized and well-written material about the overall biology and management of weeds and weedy crops. Many examples of ferality are considered, because, as the editor states, readers will discover that there is no unified theory of ferality. Thanks to the incredible diversity of the plant kingdom, "Surprises abound in every chapter."

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Moving rapidly from science fiction to science fact, cryopreservation is an integral part of many research, development, and production processes in industry and academia. The preservation sciences have emerged as an interdisciplinary platform that incorporates the fundamentals of cell and molecular biology, and bioengineering, with the classic methodological approaches to freezing and drying living matter. Researchers and biotech companies must scramble to learn about, and adopt, the new preservation strategies that incorporate the classic and the new molecular-based approaches.The first reference of its kind, Advances in Biopreservation addresses the breadth of the field of biopreservation. Written by recognized international leaders in biopreservation, the book expertly integrates recent molecular-based discoveries with classically-based biopreservation basics, offering a new look at advances in the emerging regenerative medicine arena. In addition to general concepts of biopreservation, it includes chapters detailing subspecialty principles, such as biologically active macromolecules, stem cells, and gene therapy, as well as new protocols for cell, tissue, and organ preservation. The classically based approaches to biopreservation are now recognized as bottlenecks to advances in the emerging regenerative medicine arena. Recent discoveries have changed the basic foundations upon which the preservation sciences were built. Integrating the concepts of first generation cryopreservation with the new paradigm, this book is a fundamental reference to the latest advances in the field.

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Nicotine research has been conducted for the better part of a century, but with the discovery of the relationship of nicotinic systems to Alzheimer's disease, the differentiation of nicotinic receptor subtypes, and the development of novel nicotinic ligands, the field of nicotine research has exploded. This book will provide you reference to the latest research methods and findings concerning nicotinic neural systems.Featuring a unique approach, Nicotinic Receptors in the Nervous System provides integrated coverage of cutting-edge research concerning neuronal nicotinic systems relevant to smoking addiction and cognitive dysfunction. By bringing together molecular and neurochemical applications, this book provides the key to understanding function and dysfunction of nicotinic systems and how they are significant for disease, addiction, and the development of novel drug treatments. Within the next several years, it is very promising that clinical research will support the use of nicotinic treatments for addiction, pain, and cognitive and motor dysfunction. Nicotinic Receptors in the Nervous System provides you with the basic mechanistic background for these treatments as well as the functional assessment necessary to determine therapeutic effects.

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