Search results for ""taylor francis inc""

Newcomers to the field of biopharmaceuticals require an understanding of the basic principles and underlying methodology involved in developing protein- and nucleic acid-based therapies for genetic and acquired diseases.Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids introduces the principles of polymer science and chemistry, as well as the basic biology required for understanding how biomaterials can be used as drug-delivery vehicles. No book to date combines a discussion of high-tech biomaterials-based delivery of protein and nucleic acid drugs with the pharmaceutical or biocompatibility aspects. Featuring contributions from leading experts from around the world, this text discusses physiochemical parameters used for design, development, and evaluation of biotechnological dosage forms for delivery of proteins, peptides, oligonucleotides, and genes. The authors also present biological barriers to extravasation and cellular uptake of proteins and nucleic acids.Combining an introduction to biomaterial delivery with the latest developments in the field, this is a valuable reference for both the novice student and the practicing scientist on delivery of biomaterials, on biomedical polymers, and on polymer therapeutics. Understanding these core fundamentals is critical to moving on to more advanced study.

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This pocket book serves as an immediate reference for the various formulae encountered in linear systems, control systems, probability, communication engineering, signal processing, quantum mechanics, and electromagnetic field theory. It includes novel results on complex convolutions; clearly explains real and complex matrix differentiation methods; provides an unusual amount of orthogonal functions; and presents properties of Fourier series, Fourier transforms, Hilbert transforms, Laplace transforms, and z-transforms. Singular value decomposition techniques for matrix inversion are also clearly presented.This new edition adds material from:Orthogonal functions Linear algebra Matrix analysis Matrix and vector differentiation Singular value decomposition State space techniquesOther discussions include: Discrete linear and circular convolution Gram-Schmidt orthogonalization procedure Graphical derivation of DFT from CFT Truncation windows Eigenvalues and eigenvectors of matricesThis succint resource will be particularly useful as a supplement to regular texts, designed for the master's or doctoral student as well as the advanced undergraduate.

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Supplemented with a convenient keyword index, this book provides a pocket-sized verbatim reproduction of key US FDA regulations. It presents the requirements as set forth by the FDA CFR 21 Parts 807, 812, and 814 to sell or distribute medical devices, including the pre-market approval requirements for the devices. The easy-to-use format that puts the exact section of the reg required by medical device manufacturers within easy reach. This is the perfect low-cost tool for employees as part of documented training programs; suppliers/vendors so that they may provide components, labels, and parts with an understanding of FDA requirements; and technicians charged with ensuring adherence to US FDA regulations.

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Immunologists as well investigators in other disciplines may often use protocols involving the isolation, cultures and characterization of different types of leukocytes. Advanced Methods in Cellular Immunology is a collection of techniques in an easy-to-use format.Each chapter provides readers with related program information, a step-by-step description of the methodology, alternative techniques, pertinent references, and information about commercial sources for materials and regents. In addition to leukocytes, the authors guide readers through the processes of cell culture as well as inflammation and autoimmunity in a variety of animal models.Covering topics such as PCR and Apoptosis, this book will serve a guide to commonly used procedures in cellular immunology while utilizing both human and murine models.

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Dietary Proteins and Atherosclerosis provides a thorough review of the role of proteins in the development of atherosclerosis. The author reviews early research connections between dietary fat and cardiovascular disease caused by the build-up of plaque in arteries and examines other factors that contribute to atherosclerosis, such as infection and dietary proteins. Relying on data obtained from almost 2,000 research articles and literature reviews, the author provides a thorough analytical examination and discusses how emphasis on the role of dietary fat in atherogenesis has overshadowed the critical contribution of dietary proteins to the development of cardiovascular disease.

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Written by an internationally recognized expert, this book provides a comprehensive text for physicians, nurses, and physiotherapists treating patients with acute and chronic compartment syndromes. Taking a mutlidisciplinary approach, the author delineates difficult material in a clear, concise manner that provides an easier understanding of this technical subject. The text includes the most current research and data on compartment syndromes. It presents in-depth coverage of acute and chronic compartment syndromes, considerations of interstitial space, intramuscular pressure recordings, and limb edema.

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With the availability of advanced technologies, digital systems, and communications, portable instruments are rapidly evolving from simple, stand alone, low-accuracy measuring instruments to complex multifunctional, network integrated, high-performance digital devices with advanced interface capabilities. The relatively brief treatments these instruments receive in many books are no longer adequate. Designers, engineers and scientists need a comprehensive reference dedicated to electronic portable instruments that explains the state-of-art and future directions. Electronic Portable Instruments: Design and Applications introduces the basic measurement and instrumentation concepts, describes the operating principles, and discusses the typical specifications of three main groups of portable instruments:Portable and handheld instruments built for specific applications Intelligent sensor-based devices with few components and dedicated features, such as implantable medical devices Portable data systems containing fixed sensors and supporting mechanisms, but equipped with advanced communications capabilities, such as mobile weather stationsThe author discusses sensors suitable for these instruments, addresses how components are selected, and clearly shows that instrument design centers on trade-offs between costs, performance, size and weight, power consumption, interface options, ruggedness, and the ability to operate in a range of environments. A multitude of tables, formulae, and figures--many in full color--enhance the presentation. Numerous examples of applications demonstrate the current diversity of these devices and point the way to future trends in development and applications.

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Nanoscale Technology in Biological Systems reviews recent accomplishments in the field of nanobiology and introduces the application of nanoscale matrices to human biology. It focuses on the applications of nanotechnology fabrication to biomedical devices and discusses new physical methods for cell isolation and manipulation and intracellular communication at the molecular level. It also explores the application of nanobiology to cardiovascular diseases, to oncology, to transplantation and a range of related disciplines. This book build a strong background in nanotechnology and nanobiology ideal for molecular biologists, biochemists, materials scientists, bioengineers, biotechnologists

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Conventional materials technology has yielded clear improvements in regenerative medicine. Ideally, however, a replacement material should mimic the living tissue mechanically, chemically, biologically and functionally. The use of tissue-engineered products based on novel biodegradable polymeric systems will lead to dramatic improvements in health care. The most important materials in development for use in tissue engineering, replacement, and regeneration are based on polymers and on composites reinforced with bioactive ceramics. The first book to address the topic in an integrated manner, Biodegradable Systems in Tissue Engineering and Regenerative Medicine presents an extensive description of biodegradable polymers used in medicine and explores their design, development, and processing. The authors discuss the performance of biodegradable systems and the special requirements that should be taken into account when evaluating their biocompatibility. Included are several methodologies for tailoring cell adhesion and proliferation on the surface of biodegradable polymers. This book represents a coordinated effort by outstanding international experts, and provides an integrated, forward-looking perspective. By joining together the most active groups in the field, the editors offer a unified approach, representing diverse fields of study, to produce a revolution in regenerative medicine.

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Looking beyond the traditional applications of polyurethanes (PUR), Polyurethanes as Specialty Chemicals presents a different approach to polyurethane chemistry by examining a range of new products and new research for both environmental and medical applications. This book is also the first in its field to provide useful design tools for product designers to customize the foam surface.The author examines extraction methods and biodegradability of polyurethanes for removing pollutants from air and groundwater and for sanitation/wastewater treatment. Thomson also explores the behavior of polyurethanes in a biological environment, covering a broad spectrum of applications that includes artificial organs, chelating agents for pharmaceuticals, and delivery systems for skin care products and cosmetics. The in-depth treatment of biochemical processes and cellular interaction includes tissue response, cell adhesion, 3D cell scaffolding for cell propagation, the immobilization of enzymes, and the production of proteins. Other topics of interest include agricultural applications and the use of PUR as an analytical/diagnostic system for testing toxicity without the use of animals.Destined to become indispensable in its field, Polyurethanes as Specialty Chemicals explores conventional PUR and its composites - emphasizing formulations, reticulated foams and hydrophilics - as versatile structures that can be used for specific design objectives in environmental and medical applications.

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The field of microwave engineering has undergone a radical transformation in recent years, as commercial wireless endeavors overtook defense and government work. The modern microwave and RF engineer must be knowledgeable about customer expectations, market trends, manufacturing technologies, and factory models to a degree that is unprecedented. Unfortunately, most of the available literature does not reflect this fact, but remains focused on high-performance, low-volume applications.Microwave and RF Product Applications helps resolve that deficiency. Editor Mike Golio culled its chapters from his bestselling RF and Microwave Handbook, incorporated critical updates contributed by the original authors, and organized the chapters into a practical, tightly focused reference. A complete table of contents at the front of the text makes finding specific answers quick and easy, and detailed lists of references in each chapter provide convenient access to the relevant expert literature.For engineers in industry, government, or academia, Microwave and RF Product Applications provides insight and information that may be outside their area of expertise. For managers, marketers, and technical support personnel, it builds a better understanding of the fields that drive and are affected by their decisions.

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The average cost of an uncomplicated patent application filing is about $10,000. This high cost can leave thousands of inventors out in the cold. Filing Patents Online: A Professional Guide is a complete manual that walks inventors through each step of filing and prosecuting the patent online at a fraction of the cost. The online filing system recommended in the book allows continuous monitoring of the review status and for a much faster approval than the traditional route. Drawing from the many years of the author's experience as both an inventor and a patent agent, this guide teaches the methods of research, planning, and the art of writing winning claims that will result in commercially valuable patents.

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Synthesis of Carbon-Phosphorus Bonds, Second Edition is a working guide for the laboratory, incorporating classical approaches with the recent developments of carbon-phosphorus (C-P) bond formation. These advances include the preparation of phosphoranes - specifically in the use of transient oxophosphoranes as intermediates in organophosphorus compound synthesis ñ along with the new approaches towards the preparation of compounds with aromatic and vinylic C-P bonds.Synthesis of Carbon-Phosphorus Bonds, Second Edition serves as a useful tool in the laboratory. It offers detailed surveys of IUPAC nomenclature recommendations, common notation systems, and various experimental examples. These features help to make this text an effective source of critical and annotated references, as well as a a working guide for organic and phosphorus chemists specifically, or for any chemists working with C-P bonds.

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This fourth volume in the Chemical and Functional Properties of Food Components series focuses on saccharides as food constituents. Written by an international group of experts, it provides an up-to-date review of a wide spectrum of issues, focusing on the current research and literature on the properties of compounds, their mechanisms of action, and effects on the quality of foods. It also explores some non-nutritional applications of saccharides, including biodegradable materials and polysaccharide waste as a source of energy. This unique reference will serve as a valuable resource and guide for researchers, professionals, and graduate students.

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Focusing on how increased understanding of brain function affects clinical neuroscience, this incisive text explores the interface between neuroscience and clinical neuroscience advances by examining the hypotheses that drive this evolution. The author reviews the relevant underpinnings of new neurosurgical techniques, treatments, and conceptual approaches, which are likely to shape clinical neuroscience over the next decade. A critical aspect of this rational approach is to underscore what needs to be done in each field, potentially leading to further study and improvements.

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Identity-Preserved Systems: A Reference Handbook provides background for the development of processes or systems of maintaining the segregation of and documenting the identity of a product. Growers and other parties that handle, transport, condition, or process the identity-preserved (IP) product must follow strict growing and handling practices, including segregation, inspections, and cleaning of equipment to prevent other varieties from mixing with or contaminating the IP variety. The key to this system is traceability. Each production, processing, and delivery step is documented, so that products can be traced from the store shelf back to the farmers' fields and every stage in between.The need for Identity Preservation (IP) is rapidly becoming of major importance in the world trade of agricultural crops that are enhanced genetically, grown under specific conditions, or have specific characteristics which must be identified and maintained from the seed planted to the delivery of the crop to the end-user. The handbook serves as an authoritative resource that unifies IP efforts, outlines the protocols for IP systems, and includes an operational manual that may be used at any point in the value-chain of the production and marketing effort. This handbook describes an overall identity-preserved (IP) system, which may be utilized in ways that will meet the particular needs of the parties involved in specific trade agreements. It discusses the background of IP systems originating in the seed industry, the basics of a total IP system, and the potential electronic transfer of data and documents. By using the system of identity-preserved verification provided in Identity-Preserved Systems, the seed, specialty crop, and grain and oilseed industries can easily provide products that are identified with a paper trail verifying identity, product quality, and special characteristics.

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The development and implementation of a new chemical process involves much more than chemistry, materials, and equipment. It is a very complex endeavor and its success depends on the effective interactions and organization of professionals in many different positions - scientists, chemical engineers, managers, attorneys, economists, and specialists. Developing An Industrial Chemical Process: An Integrated Approach is the first professional reference to examine the actual process development practices of industrial corporations, research organizations, engineering companies and universities. Backed by 45 years of experience within R&D, design, and management positions in various countries, the author presents his know-how for better and faster results and fewer start-up problems. While most books on chemical processes concentrate only on the scientific/technical aspect, this book also deals with the range of people and "real life" issues involved.Developing An Industrial Chemical Process serves as a "how to" guide for the effective management of process development procedures. The issues start with the "why" and "how" concerns of the executives and project managers and proceed with the actual implementation by professionals, each in his/her particular role. The author addresses the working organization and the different activities involved in a process development program, including the implementation, design, construction and start-up of a new plant. Finally, each chapter provides a short summary of the key issues along with suggestions for further reading. This book can help you handle the problems normally associated with the development and implementation of a new process and reduce the time and resources that you and your organization spend on this critical activity.

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The first state-of-the-art review of this dynamic field in a decade, Modeling Microbial Responses in Foods provides the latest information on techniques in mathematical modeling of microbial growth and survival. The comprehensive coverage includes basic approaches such as improvements in the development of primary and secondary models, statistical fitting strategies, and novel data collection methods. An international team of experts explore important developing areas, including specific applications, challenges in applying models to foods, variability and uncertainty, and new modeling strategies. The authors present detailed descriptions of non-linear regression fitting, methods, approaches relevant to 'real world' situations, and extensive applications of predictive models. They conclude by highlighting the strengths and weaknesses in the field and areas for future work, and attempt to resolve some of the outstanding conflicts. The book includes strategies for combining databases, improving researcher networks, and standardization of applications packages. Providing the uninitiated with enough information to begin developing their own models, Modeling Microbial Responses in Foods covers all aspects of growth and survival modeling from the primary stage of gathering data to the implementation of final models in appropriate delivery systems.

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Communication problems between science and the courts are widely deplored and sometimes exploited by a variety of groups. The U.S. Supreme Court has twice tightened the law of evidence to control the flow of information, but amazingly little has been written to analyze the nature of the problem and reduce the barriers. Expert Witnesses: Explaining and Understanding Science results from the first-hand experience of the contributors-who include scientists, expert witnesses, litigators, and a judge-that the cultural and interdisciplinary communications barriers between science and the law can be greatly reduced to everybody's advantage if the parties understand and respect each other's needs and positions.

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To gain a complete overview of what is presently known about molecular carcinogenesis would prove to be a very daunting task for those not already steeped in this complex subject. Fortunately, David Warshawsky and Joseph Landolph Jr., both highly respected for their own contributions to the field, know exactly whom to call upon to fulfill the need for a definitive summary.Molecular Carcinogenesis and the Molecular Biology of Human Cancer provides a technical, as well as historical, overview of research covering the science of cancer. This volume explores molecular information specific to chemical, viral, and radiation carcinogenesis, explains the working of cellular oncogenes and tumor suppressor genes, and also introduces readers to the latest genomic and proteomic approaches. The first part of the book offers basic information; the second part deals strictly with cancer in humans. It commences with discussions on induction and exposure, then reviews complex mixtures of chemical carcinogens, and provides several chapters on tumors, organized by specific organs. This section also covers chemoprevention of chemical carcinogenesis, exposure assessment, and biomarkers, as well as the role of risk assessment, before offering a discussion on prevention that includes the history and particulars of carcinogen regulations. Featuring leading researchers writing about their areas of expertise, this book provides a succinct yet detailed reference that meets the needs of professional researchers, clinicians, and environmental regulators, as well as attorneys practicing law in the area of toxic torts. Its progressive structure allows it to also serve as a primary text or resource for students in medicine and cancer research.

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The development of near-field optics marked a major advance in microscopy and our ability to develop nanoscale technologies. However, the tapered optical fiber widely in use as the optical near-field probe has serious limitations in its fabrication, its optical transmission efficiency, and its use in arrays.Fabrication of Silicon Microprobes for Optical Near-Field Applications reports on several technological approaches to using silicon micromachining techniques for fabricating microprobes without the drawbacks of conventional optical fiber probes. The authors have developed a simple, effective method for batch-process production of silicon cantilevered probes with apertures as small as 20 nanometers. They have investigated in detail the probes' optical performance characteristics and show how the silicon probes overcome the limitations of the optical fiber probes in terms of production throughput, optical throughput, reproducibility, simplicity of instrumentation, and mechanical performance.

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Now for the first time, one comprehensive book summarizes and analyzes the numerous scientific papers and reviews covering selected aspects of the structure, biological activities, and clinical effects of immune interferon, also known as interferon-gamma(IFN-gamma). Immune Interferon: Properties and Clinical Applications is essential reading for anyone working with interferons.Having developed their own brand of interferon-gamma, the authors have become well known for their research and significant contributions in the fields of molecular biology, biochemistry, and interferon-gamma. They bring together the extensive findings from years of research since the discovery of the drug. Focusing on the drug itself and not particular brands, the book presents data on the properties of interferon-gamma, experimental data on its effects in cell cultures in vitro and on animals in vivo, the role that IFN-gamma plays in different diseases, and the results of its clinical applications.As interest in this versatile drug continues to grow, new avenues for its clinical use will continue to arise. Within a single source, Immune Interferon: Properties and Clinical Applications provides you with thorough information on all facets of interferon-gamma, from biological properties, to pharmaceutical processing, to clinical application.

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For more than six years, The Communications Handbook stood as the definitive, one-stop reference for the entire field. With new chapters and extensive revisions that reflect recent technological advances, the second edition is now poised to take its place on the desks of engineers, researchers, and students around the world.From fundamental theory to state-of-the-art applications, The Communications Handbook covers more areas of specialty with greater depth that any other handbook available. Telephony Communication networks Optical communications Satellite communications Wireless communications Source compression Data recording Expertly written, skillfully presented, and masterfully compiled, The Communications Handbook provides a perfect balance of essential information, background material, technical details, and international telecommunications standards. Whether you design, implement, buy, or sell communications systems, components, or services, you'll find this to be the one resource you can turn to for fast, reliable, answers.

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Facilities increasingly rely on computerized systems to optimize their buildings' systems operation and reduce the costs of maintenance and management. Therefore, facility managers and engineers must rise to the challenge of a new discipline-systems networking and integration-as more and more computerized systems become implemented.

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This handbook explains principles, processes, methods, and procedures of optical engineering in a concise and practical way. It emphasizes fundamental approaches and provides useful formulas and step-by-step worked-out examples to demonstrate applications and clarify calculation methods. The book covers refractive, reflective, and diffractive optical components; lens optical devices; modern fringe pattern analysis; optical metrology; Fourier optics and optical image processing; electro-optical and acousto-optical devices; spatial and spectral filters; optical fibers and accessories; optical fabrication; and more. It includes over 2,000 tables, flow charts, graphs, schematics, drawings, photographs, and mathematical expressions.

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Synthesizing disparate information into a readily accessible format, this insightful volume presents state-of-the-art reviews on the basic and clinical features of pulmonary diseases in HIV-infected individuals-informing critical decision making as well as suggesting avenues for future research. A beneficial compendium for those dealing with pulmonary complications of HIV infection, Human Immunodeficiency Virus and the Lungsurveys current knowledge on the epidemiology of HIV infection examines HIV's effects on lung cells in addition to immune functions within the lung details individual pulmonary infections in terms of etiology, clinical presentation, diagnosis, treatment, and prophylaxis emphasizes the indications and limitations of various diagnostic techniques, including invasive and noninvasive testing and screening considers noninfectious pulmonary complications from neoplastic and inflammatory to immunological disorders advises on the management of individuals in intensive care with the aid of morbidity and mortality data assesses common recommendations as well as provides clear guidelines for preventing the transmission of infectious pathogens and more!

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Offers an integrated presentation of the microbial, agronomic and recycling aspects of soil faunal potentials, emphasizing agricultural ecosystems and furnishing methods for modelling food webs. The text covers morphology, reproduction, abundances, basic requirements, competition, predation, parasitism, nutrient cycling and phytopathological interactions, soil physics and agricultural management, plus methods to quantify soil faunal groups.

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This reference presents cutting-edge basic and clinical research on all forms of interferon (IFN) involvement in the management of multiple sclerosis (MS)-detailing topics from IFN-receptor molecular interactions to synergy and interference with other agents such as cytotoxic drugs and chemotherapy. Features detailed research findings on IFN ß -1a (Avonex) and IFN -1b (Betaseron).

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"Comprehensively covers all phases of the application of Total Quality Management (TQM) to product design and development--from initial concept to customer support--addressing statistical quality control, manufacturing engineering, processes and procedures management, and motivation management. Provides rigorous definitions of the principles of TQM."

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This work introduces scientists of all disciplines to the chromatographic process and how it functions. The basic principles of chromatographic separation and specific chromatographic procedures, including gas, liquid and thin-layer chromatography, are covered. For each separation method the book details its characteristics, the instrumentation required, the procedures necessary for effective use, areas of application and examples of its use.;This work is intended for analytical chemists, laboratory technicians, and upper-level undergraduate and graduate students in analytical chemistry or separation science courses.

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This volume examines the contributions of proteins to the technological and organoleptic characteristics of food. It provides a solid basis for understanding the principles of food protein functionality and offers information to help develop unique food products using proteins as novel ingredients. Properties such as solubility, viscosity, gelation, emulsification and loam formation are discussed.

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Integrates two fields generally held to be incompatible, if not downright antithetical, in 16 lectures from a February 1990 workshop at the Argonne National Laboratory, Illinois. The topics, of interest to industrial and applied mathematicians, analysts, and computer scientists, include singular per

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A Druid looks at quality control for product and service industries, amplifying from his earlier book Right first time . Some highlights: Quality is a religion, with the same trappings and pitfalls as other religions; humanity can be distorted, but not abolished, by managerial decree and organizatio

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The Advances in Chromatography series provides the most up-to-date information on a wide range of developments in chromatographic methods and applications. For more than five decades, scientists and researchers have relied upon this series to cover the state of the art in separation science. With contributions from among the leading researchers around the world, this respected series continues to present timely, cutting-edge reviews in the fields of bio-, analytical, organic, polymer, and pharmaceutical chemistry. With contributions from leading authorities, this is an enriching guide for analytical, organic, inorganic, clinical, and physical chemists; chromatographers; biochemists and biotechnologists; scientists in Academia, government, hospitals and industry in both research and quality control. This is Volume 27 originally published in 1987.

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Edited by world-renowned bariatric surgeons, this comprehensive reference provides a clear overview of multidisciplinary approaches to bariatric surgery and clearly details the techniques and outcomes of commonly performed bariatric operations, potential complications associated with bariatric surgery, and practices in long-term follow-up and nutritional management.

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Providing in-depth coverage of the technologies and various approaches, Luminous Chemical Vapor Deposition and Interface Engineering showcases the development and utilization of LCVD procedures in industrial scale applications. It offers a wide range of examples, case studies, and recommendations for clear understanding of this innovative science. The book comprises four parts. Part 1 describes the fundamental difference between glow discharge of an inert gas and that of an organic vapor, from which the concepts of Luminous Gas Phase derive. Part 2 explores the various ways of practicing Luminous Vapor Disposition and Treatment depending on the type and nature of substrates. Part 3 covers some very important aspects of surface and interface that could not have been seen clearly without results obtained by application of LCVD. Part 4 offers some examples of interface engineering that show very unique aspects of LCVD interface engineering in composite materials, biomaterial surface and corrosion protection by the environmentally benign process. Timely and up-to-date, the book provides broad coverage of the complex relationships involved in the interface between a gas/solid, liquid/solid, and a solid/solid. The author presents a new perspective on low-pressure plasma and describes key aspects of the surface and interface that could not be shown without the results obtained by LCVD technologies.FeaturesProvides broad coverage of complex relationships involved in interface between a gas/solid, a liquid/solid, and a solid/solid Addresses the importance of the initial step of creating electrical glow discharge Describes the principles of creating chemically reactive species and their growth in the luminous gas phase Focuses on the nature of surface-state of solid and on the creation of imperturbable surface-state by the contacting phase or environment, which is vitally important in creating biocompatible surface, providing super corrosion protection of metals by environmentally benign processes, etc. Offers examples on how to use LCVD in the interface engineering process Presents a new view on low-pressure (low-temperature) plasma and emphasizes the importance of luminous gas phase and chemical reactions that occur in the phaseAbout the author:Dr. Yasuda is one of the pioneers who explored low-pressure plasma for surface modification of materials and deposition of nano films as barrier and perm-selective membranes in the late 1960s. He obtained his PhD in physical and polymer chemistry working on transport properties of gases and vapors in polymers at State University of New York, College of Environmental Science and Forestry at Syracuse, NY. He has over 300 publications in refereed journals and books, and is currently a Professor Emeritus of Chemical Engineering, and Director, Center for Surface Science & Plasma Technology, University of Missouri-Columbia, and is actively engaged in research on the subjects covered by this book.

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Addressing a topic of major importance to the maintenance of world food supplies, this reference identifies knowledge gaps, defines priorities, and formulates recommendations for the improvement of the rice-wheat farming system. The book reveals new systems of rice intensification and management and illustrates the application of no-till and conservation farming to the rice-wheat system. With contributions from 65 international experts, and case studies from India, Nepal, Pakistan, and Bangladesh, Sustainable Agriculture and the International Rice-Wheat System focuses on seeding equipment and residue management, weed control, water and nutrient efficiency, and integrated pest management.

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Virtual screening can reduce costs and increase hit rates for lead discovery by eliminating the need for robotics, reagent acquisition or production, and compound storage facilities. The increased robustness of computational algorithms and scoring functions, the availability of affordable computational power, and the potential for timely structural determination of target molecules, have provided new opportunities for virtual screening, and made it more practical. Why then, isn’t everyone using virtual screening? Examining the scope and limitations of this method, Virtual Screening in Drug Discovery explores the algorithms involved and how to actually use them.Part I offers perspectives on both ligand-based and docking-based virtual screens. The authors of these chapters frame many of the challenges currently facing the field. Part II considers the choice of compounds that are best suited as drug leads. Part III discusses ligand-based approaches, including descriptor-based similarity, traditional pharmacophore searching, and similarity based 3D-pharmacophore fingerprints. The final two sections are devoted to molecular docking. Part IV outlines some important and practical considerations relating to the energetics of protein-ligand binding and target-site topography, whereas specific docking algorithms and strategies are discussed in Part V. Notwithstanding this list of subjects, the book does not overwhelm you with more information than you need—many of the strategies outlined will transcend the specifics of any given method. Nor does the book purport to offer single best ways to use the programs. What it does is provide a snapshot of virtual screening that gives you easy access to strategies and techniques for lead discovery.Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug di

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Chemists increasingly apply electrochemical methods to the investigation of their systems, in particular towards a better understanding of molecular properties, the exploration of chemical reactions involving electron-transfer (ET), the initiation of further reactions by ET, the kinetic measurements, and the establishment of the reaction mechanisms, as well as the synthesis (electrosynthesis) of desired products.Trends in Molecular Electrochemistry presents recent research on procedures in molecular electroactivation and electrocatalysis, bioelectrochemistry, spectroelectrochemistry, and unconventional electrochemistry. The book highlights the state-of-the-art in the application of electrochemistry by taking an interdisciplinary approach to the study of both static and dynamic molecular properties of coordination compounds as well as inorganic, bioinorganic, and organometallic complexes, supramolecular systems, and metalloenzymes. The principles and approaches are often also valid for organic systems, which are illustrated in various contexts.

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Examining processes that affect more than 70 percent of consumer products ranging from computers to medical devices and automobiles, this reference presents the latest research in automated plastic injection and die casting mold design and manufacture. It analyzes many industrial examples and methodologies while focusing on the algorithms, implementation procedures, and system architectures that will lead to a fully automated or semi-automated computer-aided injection mold design system (CADIMDS). This invaluable guide in this challenging area of precision engineering summarizes key findings and innovations from the authors' many years of research on intelligent mold design technologies.

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The Mathematical Theory of Tone Systems patterns a unified theory defining the tone system in functional terms based on the principles and forms of uncertainty theory. This title uses geometrical nets and other measures to study all classes of used and theoretical tone systems, from Pythagorean tuning to superparticular pentatonics. Hundreds of examples of past and prevalent tone systems are featured. Topics include Fuzziness and Sonance, Wavelets and Nonspecificity, Pitch Granulation and Ambiguity, Equal Temperaments, Mean Tone Systems. Well Tempered Systems, Ptolemy Systems, and more. Appendices include extended lists of tone systems and a catalogue of historical organs with subsemitones.

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Electrokinetic Phenomena emphasizes the impact of methods such as capillary zone electrophoresis, capillary electrochromatography, and capillary gel electrophoresis on the analysis of biomolecules. This reference reveals the electrokinetic phenomena that underlie high-performance electro-based analytical tools and vividly depicts how electrodriven analytical tools revolutionize and expedite chemical, pharmaceutical, and biotechnological analysis. An authoritative overview, the book provides effective pathways for large-scale biomedical applications and describes how microfabricated and automated devices enhance and accelerate the analysis of biologically important molecules.

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The Metal Ions in Biological Systems series is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. Written by 36 internationally recognized experts and enriched with nearly 200 illustrations, Volume 40 highlights fast moving research on lanthanides and their interrelations with biosystems and emphasizes their recent impact in biochemical and biological studies, and in medicine.

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Covering major standards and relevant design issues, this book explains how to specify, install, and test a modern reliable structured cabling system and analyzes the terminology and physics behind the standards. The author empowers the reader with the skills required to read and understand standards and address problems raised by the need to design, procure, install, and test a modern cabling system, using both copper and optical fiber cable technology. He thoroughly discusses the technology and the vast number of standards that accompany it. The material is based on the design recommendations of ISO/IEC 11801. The appendix lists relevant standards and provides contacts for standards organizations.

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Promoting developments in the diagnosis, prevention, and treatment of coronary artery disease, this reference furnishes the latest information on new and emerging risk factors for atherothrombotic vascular disorders-analyzing lipid-related and psychosocial risk factors, the genetic aspects of disease, the potential role of infection and inflammation, metabolic syndrome and insulin resistance, and elevated blood levels of homocysteine and hemostatic factors.

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The latest addition to this lauded series, this reference collects pioneering research on the chemistry and physics of carbon surfaces and the structural properties of carbons. Written by distinguished researchers affiliated with respected institutions, such as the Instituto Nacional del Carbón (INCAR) and the University of Reading, Chemistry and Physics of Carbon provides a comprehensive overview of the molecular structure of carbons and demonstrates how modern computational and modeling methods may contribute to the prediction of carbon material adsorption, separation, and diffusion. Volume 29 bridges the gap between the flat and curved sp2 hybridized carbon structures and resolves controversies related to the formation of fullerenes and soot. It emphasizes theoretical interpretations and computer simulations that reflect the current trends in carbon surface physics and analyses and examines water/carbon interactions with a chapter by an authority on microporous carbons. This definitive source also summarizes current knowledge concerning all aspects of Chemical Vapor Deposition of diamond, and showcases its latest applications.

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As we reach the data transmission limits of copper wire and communications experts seek to bring the speed of long-haul fiber optics networks closer to access points, optical interconnects promise to provide efficient, high-speed data transmission for the next generation of networks and systems. They offer higher bit-rates, virtually no crosstalk, lower demands on power requirements and thermal management, and the possibility of two-dimensional channel arrays for chip-to-chip communication.The Handbook of Optical Interconnects introduces the systems and devices that will bring the speed and quality of optical transmission closer to the circuit board. Contributed by active experts, most from leading technology companies in the US and Japan, this outstanding handbook details various low-cost and small-size configurations, illustrates the discussion with more than 300 figures, and offers a look at the applications and future of this exciting and rapidly growing field. The book includes a detailed introduction to vertical cavity surface-emitting lasers (VCSELs); the use of optical interconnects in metropolitan, local-area, and access networks through FTTP (FTTH); and Jisso technologies, which are critical for developing low-cost, small-size modules.Driving down the size and cost of optical interconnects is vital for integrating these technologies into the network and onto microprocessors, and the Handbook of Optical Interconnects provides the knowledge and tools necessary to accomplish these goals.

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Exploring the causes, mechanisms, and pathophysiology of cardiac remodeling, this reference offers detailed descriptions of the various components of the remodeling process, as well as new therapeutic interventions and recent and future prospects for the treatment of cardiac remodeling.

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