Search results for ""Academia""

Linker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been developed and are now routinely employed in solid-phase synthesis. Linker Strategies in Solid-Phase Organic Synthesis guides the reader through the evolution of linker units from their genesis in solid-supported peptide chemistry to the cutting edge diversity linker units that are defining a new era of solid phase synthesis. Individual linker classes are covered in easy to follow chapters written by international experts in their respective fields and offer a comprehensive guide to linker technology whilst simultaneously serving as a handbook of synthetic transformations now possible on solid supports. Topics include: the principles of solid phase organic synthesis electrophile and nucleophile cleavable linker units cyclative cleavage as a solid phase strategy photocleavable linker units safety-catch linker units enzyme cleavable linker units T1 and T2 –versatile triazene linker groups hydrazone linker units benzotriazole linker units phosphorus linker units sulfur linker units selenium and tellurium linker units sulfur, oxygen and selenium linker units cleaved by radical processes silicon and germanium linker units boron and stannane linker units bismuth linker units transition metal carbonyl linker units linkers releasing olefins or cycloolefins by ring-closing metathesis fluorous linker units solid-phase radiochemistry The book concludes with extensive linker selection tables, cataloguing the linker units described in this book according to the substrate liberated upon cleavage and conditions used to achieve such cleavage, enabling readers to choose the right linker unit for their synthesis. Linker Strategies in Solid-Phase Organic Synthesis is an essential guide to the diversity of linker units for organic chemists in academia and industry working in the broad areas of solid-phase organic synthesis and diversity oriented synthesis, medicinal chemists in the pharmaceutical industry who routinely employ solid-phase chemistry in the drug discovery business, and advanced undergraduates, postgraduates, and organic chemists with an interest in leading-edge developments in their field.

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Psychology for Sustainability applies psychological science to so-called environmental problems that manifest when human behavior disrupts and degrades natural systems. Drawing on environmental psychology, ecopsychology, conservation psychology, and related disciplines, the authors provide an extensive review of relevant theory and research in a lively and easy-to-read style.This edition represents a substantial revision and expansion spurred by a burgeoning body of research and by global ecological, political, and social developments. Particular attention is paid to environmental justice and collective action for systems change. More than one-third of the content is entirely new, and there are more than nine hundred new references. This edition also features a new full-color design and over two hundred full-color figures, tables, and photos. Timely topics include climate change, biodiversity loss, environmental racism, Indigenous perspectives, social media, and COVID-19 and other pandemics. Content retained from the previous edition has been updated throughout. The twelve chapters are organized into four parts: What on Earth Are We Doing includes a prologue on psychology as a sustainability science, followed by three chapters that provide an overview of the ecological crisis and its historical origins, and a vision for a sustainable future. Psychology for a Sustainable Future encompasses five chapters on research methods, theory, and findings pertinent to understanding and shifting unsustainable behavior. What’s Good for the Planet is Good for Us includes two chapters that address the reciprocal relationship between planetary and human health. Being the Change We Want to See introduces two new chapters to inspire readers to take what they have learned and apply it as changemakers in the world. The first is about collective action for systemic change. The second presents a positive psychology perspective on how to tackle the ecological crisis in a way that promotes wellbeing and resilience and is personally meaningful and fulfilling. Carefully tailored to the length of a standard college semester, Psychology for Sustainability is essential reading for courses on sustainability across disciplines. It will be invaluable to people outside academia as well, including policymakers, legislators, and those working on sustainable communities. The text is also supplemented with online resources for instructors.

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Praise for the first edition:"Given the author’s years of experience as a statistician and as a founder of the first DMC in pharmaceutical industry trials, I highly recommend this book—not only for experts because of its cogent and organized presentation, but more importantly for young investigators who are seeking information about the logistical and philosophical aspects of a DMC." -S. T. Ounpraseuth, The American Statistician In the first edition of this well-regarded book, the author provided a groundbreaking and definitive guide to best practices in pharmaceutical industry data monitoring committees (DMCs). Maintaining all the material from the first edition and adding substantial new material, Data and Safety Monitoring Committees in Clinical Trials, Second Edition is ideal for training professionals to serve on their first DMC as well as for experienced clinical and biostatistical DMC members, sponsor and regulatory agency staff. The second edition guides the reader through newly emerging DMC responsibilities brought about by regulations emphasizing risk vs benefit and the emergence of risk-based monitoring. It also provides the reader with many new statistical methods, clinical trial designs and clinical terminology that have emerged since the first edition. The references have been updated and the very popular end-of-chapter Q&A section has been supplemented with many new experiences since the first edition. New to the Second Edition: Presents statistical methods, tables, listings and graphs appropriate for safety review, efficacy analysis and risk vs benefit analysis, SPERT and PRISMA initiatives. Newly added interim analysis for efficacy and futility section. DMC responsibilities in SUSARs (Serious Unexpected Serious Adverse Reactions), basket trials, umbrella trials, dynamic treatment strategies /SMART trials, pragmatic trials, biosimilar trials, companion diagnostics, etc. DMC responsibilities for data quality and fraud detection (Fraud Recovery Plan) Use of patient reported outcomes of safety Use of meta analysis and data outside the trial New ideas for training and compensation of DMC members Jay Herson is Senior Associate, Biostatistics, Johns Hopkins Bloomberg School of Public Health where he teaches courses on clinical trials and drug development based on his many years experience in clinical trials in academia and the pharmaceutical industry.

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Addresses the Challenges Associated with System-on-Chip Integration Network-on-Chip: The Next Generation of System-on-Chip Integration examines the current issues restricting chip-on-chip communication efficiency, and explores Network-on-chip (NoC), a promising alternative that equips designers with the capability to produce a scalable, reusable, and high-performance communication backbone by allowing for the integration of a large number of cores on a single system-on-chip (SoC). This book provides a basic overview of topics associated with NoC-based design: communication infrastructure design, communication methodology, evaluation framework, and mapping of applications onto NoC. It details the design and evaluation of different proposed NoC structures, low-power techniques, signal integrity and reliability issues, application mapping, testing, and future trends.Utilizing examples of chips that have been implemented in industry and academia, this text presents the full architectural design of components verified through implementation in industrial CAD tools. It describes NoC research and developments, incorporates theoretical proofs strengthening the analysis procedures, and includes algorithms used in NoC design and synthesis. In addition, it considers other upcoming NoC issues, such as low-power NoC design, signal integrity issues, NoC testing, reconfiguration, synthesis, and 3-D NoC design. This text comprises 12 chapters and covers: The evolution of NoC from SoC—its research and developmental challenges NoC protocols, elaborating flow control, available network topologies, routing mechanisms, fault tolerance, quality-of-service support, and the design of network interfaces The router design strategies followed in NoCs The evaluation mechanism of NoC architectures The application mapping strategies followed in NoCs Low-power design techniques specifically followed in NoCs The signal integrity and reliability issues of NoC The details of NoC testing strategies reported so far The problem of synthesizing application-specific NoCs Reconfigurable NoC design issues Direction of future research and development in the field of NoC Network-on-Chip: The Next Generation of System-on-Chip Integration covers the basic topics, technology, and future trends relevant to NoC-based design, and can be used by engineers, students, and researchers and other industry professionals interested in computer architecture, embedded systems, and parallel/distributed systems.

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It’s not you, it’s the food. We have entered a new age of eating. For the first time in human history, most of our calories come from an entirely novel set of substances called Ultra-Processed Food. There’s a long, formal scientific definition, but it can be boiled down to this: if it’s wrapped in plastic and has at least one ingredient that you wouldn’t find in your kitchen, it’s UPF. These products are specifically engineered to behave as addictive substances, driving excess consumption. They are now linked to the leading cause of early death globally and the number one cause of environmental destruction. Yet almost all our staple foods are ultra-processed. UPF is our food culture and for many people it is the only available and affordable food. In this book, Chris van Tulleken, father, scientist, doctor, and award-winning BBC broadcaster, marshals the latest evidence to show how governments, scientists, and doctors have allowed transnational food companies to create a pandemic of diet-related disease. The solutions don’t lie in willpower, personal responsibility, or exercise. You’ll find no diet plan in this book—but join Chris as he undertakes a powerful self-experiment that made headlines around the world: under the supervision of colleagues at University College London he spent a month eating a diet of 80 percent UPF, typical for many children and adults in the United States. While his body became the subject of scientific scrutiny, he spoke to the world’s leading experts from academia, agriculture, and—most important—the food industry itself. But more than teaching him about the experience of the food, the diet switched off Chris’s own addiction to UPF. In a fast-paced and eye-opening narrative he explores the origins, science, and economics of UPF to reveal its catastrophic impact on our bodies and the planet. And he proposes real solutions for doctors, for policy makers, and for all of us who have to eat. A book that won’t only upend the way you shop and eat, Ultra-Processed People will open your eyes to the need for action on a global scale.

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“...a much-needed handbook with contributions from well-chosen practitioners. A primary accomplishment is to provide guidance for those involved in modeling and simulation in support of Systems of Systems development, more particularly guidance that draws on well-conceived academic research to define concepts and terms, that identifies primary challenges for developers, and that suggests fruitful approaches grounded in theory and successful examples.” Paul Davis, The RAND Corporation Modeling and Simulation Support for System of Systems Engineering Applications provides a comprehensive overview of the underlying theory, methods, and solutions in modeling and simulation support for system of systems engineering. Highlighting plentiful multidisciplinary applications of modeling and simulation, the book uniquely addresses the criteria and challenges found within the field. Beginning with a foundation of concepts, terms, and categories, a theoretical and generalized approach to system of systems engineering is introduced, and real-world applications via case studies and examples are presented. A unified approach is maintained in an effort to understand the complexity of a single system as well as the context among other proximate systems. In addition, the book features: Cutting edge coverage of modeling and simulation within the field of system of systems, including transportation, system health management, space mission analysis, systems engineering methodology, and energy State-of-the-art advances within multiple domains to instantiate theoretic insights, applicable methods, and lessons learned from real-world applications of modeling and simulation The challenges of system of systems engineering using a systematic and holistic approach Key concepts, terms, and activities to provide a comprehensive, unified, and concise representation of the field A collection of chapters written by over 40 recognized international experts from academia, government, and industry A research agenda derived from the contribution of experts that guides scholars and researchers towards open questions Modeling and Simulation Support for System of Systems Engineering Applications is an ideal reference and resource for academics and practitioners in operations research, engineering, statistics, mathematics, modeling and simulation, and computer science. The book is also an excellent course book for graduate and PhD-level courses in modeling and simulation, engineering, and computer science.

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Applied Malting and Brewing Science The landmark guide to malting and brewing science is available in English for the first time Humans have been producing fermented beverages for at least ten thousand years. Chief among them is beer, which has arguably never been more popular than it is at this point in history. The United States alone boasts more than 9,500 breweries, a number which has risen steadily as the market for craft beer continues to grow in that country. Thus, maltsters and brewers there and around the world are constantly looking for ways to hone their skills to create products of the highest quality as consistently as possible. With the detailed information presented in this book, they will not only be able to reacquaint themselves with the basic tenets of their profession but will also acquire an in-depth scientific foundation and a wide range of practical knowledge in all aspects of advanced malting and brewing. This landmark work on malting and brewing, originally entitled Abriss der Bierbrauerei, is currently in its eighth edition and has hitherto only been offered in the German language. However, it is now finally available for the first time in translation, as an unabridged and updated English edition. Applied Malting and Brewing Science is a reference for those interested in any facet of malt and beer production, including all of the most recent technical innovations in equipment and processes. This book represents the collective knowledge amassed over many decades of research by Ludwig Narziß in his tenure as Professor at the Chair for Brewing Technology at Weihenstephan. Readers of Applied Malting and Brewing Science will find the following: Comprehensive treatment of topics covering raw materials, malt and wort production, fermentation, packaging and much more A team of authors with decades of experience in the fields of malting and brewing science, both in academia and in their application in the industry A design which facilitates use of the book as both a student textbook and as a practical guide Written by the late Ludwig Narziß and his team, Applied Malting and Brewing Science is an indispensable source for students at any level in related scientific disciplines and for anyone working in the malting and brewing industry.

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The Science of Chocolate leads the reader to an understanding of the complete chocolate making process and includes the ways in which basic science plays a vital role in its manufacture, testing and consumption. Originally based upon a talk to encourage school children to study science, the book is now widely used within industry and academia. The third edition of this international best seller has been fully revised and updated. The author has now included methods of sensory evaluation, designing and modifying chocolate flavour to suit the product and the history and manufacture of some well-known confectionery products. Fat, calorie and sugar reduction are also covered including a review of patents in this area. In addition, the section on why chocolate might be good for you has been updated to include some more recent research results. Three new experiments have been added, so there are now twenty of them, which use simple materials and apparatus to demonstrate the scientific and mathematical principles found in the rest of the book. Most are easily adapted to suit different student abilities. This book will appeal to those with a fascination for chocolate and will be of specialist interest to those studying food sciences and working in the confectionery industry. Extracts from reviews of 2nd Edition: "...I found this to be an interesting read, and I think the book would be useful to graduates thinking of a career in the food industry (and not just the chocolate industry specifically), to schoolteachers looking for some interesting experiments, and to lecturers (Chemistry, Biochemistry, Botany, Food science) looking for interesting facts to enliven their lectures." Bioscience Education, Volume 12, 2008, E J Wood. "...very well written and complete book for everyone who wants to learn more about chocolate and its production process." Crystallography Reviews, Volume 15, 2009 – Issue 4, pages 275-277, Henk Schenk. "The easy reading style of the book makes it valuable not only to school and university students, but also to those who are new to working with chocolate or those needing a good summary of chocolate science." Chemistry World, for the Christmas Books

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In Get Trump: The Threat to Civil Liberties, Due Process, and Our Constitutional Rule of Law, Alan Dershowitz—#1 New York Times bestselling author and one of America’s most respected legal scholars—analyses the unremitting efforts by political opponents of Donald Trump to “get” him—to stop him from running in 2024—at any cost. Alan Dershowitz has been called “one of the most prominent and consistent defenders of civil liberties in America” by Politico and “the nation’s most peripatetic civil liberties lawyer and one of its most distinguished defenders of individual rights” by Newsweek.Get Trump makes clear that unconstitutional efforts to stop Trump from retaking the presidency challenge the very foundations of our liberty: due process, right to counsel, and free speech. Those who justify these dangerous departures from the rule of law argue that the threat posed by a second Trump presidency is “different” and “immediate,” while the departures from constitutional norms are longer term and more abstract. Dershowitz explains that defenders of Trump’s constitutional rights—even those like him who oppose Trump politically—are sought to be silenced; their free speech rights attacked, their integrity questioned, and their careers threatened. Much of the media substitutes advocacy against Trump for objective reporting, while many in academia petition and propagandize against rights they previously valued—all in the interest of getting Trump. The essence of justice is that it must be equally applicable to all, Dershowitz notes. No one is above the law but digging to find crimes in order to influence an election does not constitute the equal application of the law. In order to assure equal application in comparable situations, he proposes two criteria for indicting a likely candidate of the opposing party: the Richard Nixon standard and the Hillary Clinton standard—and most recently, the Joe Biden standard.Get Trump warns that regardless of whether this anti-democratic effort to stop Trump from running succeeds or fails, it is likely to create dangerous precedents that will lie around like loaded weapons ready to be deployed against other controversial candidates, officials, or citizens about whom it can be argued that the danger they pose “is different.”

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Java is now well-established as one of the world’s major programming languages, used in everything from desktop applications to web-hosted applications, enterprise systems and mobile devices. Java applications cover cloud-based services, the Internet of Things, self-driving cars, animation, game development, big data analysis and many more domains.The second edition of Foundational Java: Key Elements and Practical Programming presents a detailed guide to the core features of Java – and some more recent innovations – enabling the reader to build their skills and confidence though tried-and-trusted stages, supported by exercises that reinforce the key learning points. All the most useful and commonly applied Java syntax and libraries are introduced, along with many example programs that can provide the basis for more substantial applications. Use of the Eclipse Integrated Development Environment (IDE) and the JUnit testing framework is integral to the book, ensuring maximum productivity and code quality when learning Java, although to ensure that skills are not confined to one environment the fundamentals of the Java compiler and run time are also explained. Additionally, coverage of the Ant tool will equip the reader with the skills to automatically build, test and deploy applications independent of an IDE.Topics and features:• Presents the most up-to-date information on Java, including Java 14• Examines the key theme of unit testing, introducing the JUnit 5 testing framework to emphasize the importance of unit testing in modern software development• Describes the Eclipse IDE, the most popular open source Java IDE and explains how Java can be run from the command line• Includes coverage of the Ant build tool• Contains numerous code examples and exercises throughout• Provides downloadable source code, self-test questions, PowerPoint slides and other supplementary material at the website http://www.foundjava.comThis hands-on, classroom-tested textbook/reference is ideal for undergraduate students on introductory and intermediate courses on programming with Java. Professional software developers will also find this an excellent self-study guide/refresher on the topic.Dr. David Parsons is National Postgraduate Director at The Mind Lab, Auckland, New Zealand. He has been teaching programming in both academia and industry since the 1980s and writing about it since the 1990s.

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Reading this book is like sitting down with Dr. David Satcher to hear stories of leadership and lessons learned from his lifetime commitment to health equity.Dr. David Satcher is one of the most widely known and well-regarded physicians of our time. A former four-star admiral in the US Public Health Service Commissioned Corps, he served as the assistant secretary for health, the surgeon general of the United States, and the director of the Centers for Disease Control and Prevention before founding the eponymous Satcher Health Leadership Institute at Morehouse School of Medicine. At the core of his impact on public health, he is also a lifelong leader for civil rights and health equity. Born black and poor in the deep South, Dr. Satcher was a victim of an unjust health care system: he almost died of whooping cough at the age of two because Jim Crow laws meant that his black doctor could not admit him to a hospital. That experience was the first of many that shaped him as a leader and a healer deeply attuned to social inequity—someone who was determined to make a positive difference.In My Quest for Health Equity, Dr. Satcher takes an inspiring and instructive look inside his fifty-year career to shed light on the challenge and burden of leadership. Explaining that he has thought of each leadership role—whether in academia, community, or government—as an opportunity to move the needle toward health equity, he shares the hard-won lessons he has learned over a lifetime in the medical field. Drawing on his early memories, medical school days, experience in the civil rights movement, and professional highs and lows, Dr. Satcher touches on a number of topics, including• the essential qualities of leadership• leading from science to policy to practice• the importance of clear communication and continual learning• the need for workplace discipline• confronting failure• specific health issues, including the obesity epidemic, reproductive health, and mental health stigma• team approaches to leadership• and much moreIn this book, readers will discover a template for using leadership roles of all types to eliminate health disparities. My Quest for Health Equity is a vital resource for current and rising leaders.

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NANOTECHNOLOGY IN FUNCTIONAL FOODS The broad applicability of bioactive delivery systems for improving food quality, safety, and human health will make this book a valuable resource for a wide range of readers in industry, research, and academia. Functional foods is an emerging trend in the food industry, whose potential value is determined by whether they are safe with respect to consumer health. Nanotechnology in Functional Foods was written to help the reader better understand the benefits and concerns associated with these foods. In addition to giving an overview of the current state-of-the-art in functional foods, different aspects of the advanced research being conducted on their extraction, synthesis, analysis, and biological effects are presented. Besides focusing on several synthesis techniques, the book also discusses the application of nanoparticles in nutrient delivery and pharmaceuticals, such as nano-emulsions, solid lipid nanoparticles, and polymeric nanoparticles; their properties and interactions with other food components and their impact on the human body; the consumer acceptance and diversification of these nutrients. Moreover, new trends are discussed concerning the application of artificial intelligence in screening various components of functional foods. Audience The book will be central to food scientists, materials scientists, biotechnologists, medicinal chemists, pharmacists, and medical professionals. Tanima Bhattacharya, PhD, is a formulation scientist, who completed her Doctoral degree in Food Processing & Nutrition Science from the Indian Institute of Engineering Science and Technology, Shibpur, West Bengal, India and gained overseas post-doctoral experience from the College of Chemistry and Chemical Engineering Hubei University of China. She has published several scientific research articles in international peer-reviewed journals, and her research interests include the fabrication of biocompatible nanostructures and studying their properties and applications in the area of food science, technology, and biomedical sciences. Shakeel Ahmed, PhD, is an assistant professor of Chemistry at the Higher Education Department, Government of Jammu and Kashmir, India. His PhD degree in Chemistry is from Jamia Millia Islamia, A Central University, New Delhi. He has published several research publications in the area of green nanomaterials and biopolymers for various applications including biomedical, packaging, and water treatment. He has published more than 20 books in the area of nanomaterials and green materials.

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Thermal Food Engineering Operations Presenting cutting-edge information on new and emerging food engineering processes, Thermal Food Engineering Operations, the first volume in the new series, “Bioprocessing in Food Science,” is an essential reference on the modeling, quality, safety, and technologies associated with food processing operations today. As the demand for healthy food increases in the current global scenario, manufacturers are searching for new possibilities for occupying a greater share in the rapidly changing food market. Compiled reports and updated knowledge on thermal processing of food products are imperative for commercial enterprises and manufacturing units. In the current scenario, academia, researchers, and food industries are working in a scattered manner and different technologies developed at each level are not compiled to implement for the benefits of different stakeholders. However, advancements in bioprocesses are required at all levels for the betterment of food industries and consumers. This series of groundbreaking edited volumes will be a comprehensive compilation of all the research that has been carried out so far, their practical applications, and the future scope of research and development in the food bioprocessing industry. This first volume includes all the conventional and novel thermal technologies based on conduction, convection, and radiation principles and covers the basics of microbial inactivation with heat treatments, aseptic processing, retorting, drying, dehydration, combined high-pressure thermal treatments, and safety and quality concerns in food processing. Before studying the novel non-thermal processes and the concept of minimal processing, comprehensive knowledge about the conventional thermal technologies is desired along with benefits, constraints, equipment, and implementation of these technologies. Whether for the engineer, scientist, or student, this series is a must-have for any library. This outstanding new volume: Discusses food safety and quality and thermal processing, laying the groundwork for further study and research Provides case studies of solid–liquid and supercritical fluid extraction Explores pasteurization, ohmic heating, irradiation, and more Presents cutting-edge information on new and emerging food engineering processes Audience: Process and chemical engineers, chemists, engineers in other disciplines, managers, researchers, scientists, students, and teachers working in the field of food engineering and processing

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Compiles current research into the analysis and design of power electronic converters for industrial applications and renewable energy systems, presenting modern and future applications of power electronics systems in the field of electrical vehicles With emphasis on the importance and long-term viability of Power Electronics for Renewable Energy this book brings together the state of the art knowledge and cutting-edge techniques in various stages of research. The topics included are not currently available for practicing professionals and aim to enable the reader to directly apply the knowledge gained to their designs. The book addresses the practical issues of current and future electric and plug-in hybrid electric vehicles (PHEVs), and focuses primarily on power electronics and motor drives based solutions for electric vehicle (EV) technologies. Propulsion system requirements and motor sizing for EVs is discussed, along with practical system sizing examples. Key EV battery technologies are explained as well as corresponding battery management issues. PHEV power system architectures and advanced power electronics intensive charging infrastructures for EVs and PHEVs are detailed. EV/PHEV interface with renewable energy is described, with practical examples. This book explores new topics for further research needed world-wide, and defines existing challenges, concerns, and selected problems that comply with international trends, standards, and programs for electric power conversion, distribution, and sustainable energy development. It will lead to the advancement of the current state-of-the art applications of power electronics for renewable energy, transportation, and industrial applications and will help add experience in the various industries and academia about the energy conversion technology and distributed energy sources. Combines state of the art global expertise to present the latest research on power electronics and its application in transportation, renewable energy and different industrial applications Offers an overview of existing technology and future trends, with discussion and analysis of different types of converters and control techniques (power converters, high performance power devices, power system, high performance control system and novel applications) Systematic explanation to provide researchers with enough background and understanding to go deeper in the topics covered in the book

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Includes a preface written by Professor Leonard Kleinrock, Distinguished Professor of Computer Science, UCLA, USA This book discusses and explores the concept of mobile cloud, creating an inspiring research space for exploiting opportunistic resource sharing, and covering from theoretical research approaches to the development of commercially profitable ideas. A mobile cloud is a cooperative arrangement of dynamically connected communication nodes sharing opportunistic resources. In this book, authors provide a comprehensive and motivating overview of this rapidly emerging technology. The book explores how distributed resources can be shared by mobile users in very different ways and for various purposes. The book provides many stimulating examples of resource-sharing applications. Enabling technologies for mobile clouds are also discussed, highlighting the key role of network coding. Mobile clouds have the potential to enhance communications performance, improve utilization of resources and create flexible platforms to share resources in very novel ways. Energy efficient aspects of mobile clouds are discussed in detail, showing how being cooperative can bring mobile users significant energy saving. The book presents and discusses multiple examples of mobile clouds applications, based on both existing commercial initiatives as well as proof-of-concept test-beds. Visions and prospects are also discussed, paving the way for further development. As mobile networks and social networks become more and more reliant on each other, the concept of resource sharing takes a wider and deeper meaning, creating the foundations for a global real-time multidimensional resource pool, the underlying infrastructure for shareconomy. Above all, this is an inspiring book for anyone who is concerned about the future of wireless and mobile communications networks and their relationship with Social networks. Key Features: Provides fundamental ideas and promising concepts for exploiting opportunistic cooperation and cognition in wireless and mobile networks Gives clear definitions of mobile clouds from different perspectives Associates mobile and wireless networks with social networks, creating a vast fertile ground for novel developments in both research and practical applications Considers research directions, emerging trends and visions This book is an excellent resource for wireless/networking researchers in industry and academia, students and mobile phone programmers. Managers interested in new technology developments, service providers, network operators, and those working in the gaming industry will also find the book insightful.

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"Few cello players currently before the public have enjoyed the kind of international success in all conceivable musical career roles as Janos Starker. In his lifetime, Starker has gained renown as teacher, soloist and orchestra player." —Chicago Tribune"Starker . . .remains one of the wonders of the musical world, an artist who finds innumerable ways to shape and color lines." —Cleveland Plain Dealer"Starker is not just a cellist. He is widely recognized as one of the finest of the last 50 years." —Indianapolis Star"Starker emerges here as the rare artist who respects the past but lives enthusiastically in the present. . . Essential. All readers; all levels." —ChoiceJanos Starker is universally acknowledged as one of the world's great musicians. Known for a flawless technique paired with expressive playing and interpretation, the Hungarian-born cellist is arguably also the premier teacher of his instrument in our time. String players flock to his masterclasses from all over the world, and cellists compete vigorously to study under him at the Indiana University School of Music. More than the consummate musician, however, Starker is also a raconteur and writer, occasionally quirky and droll, always witty and with a pointed opinion to share.The World of Music According to Starker is a colorful autobiography spanning the author's fascinating life. From his early musical education during World War II in Hungary, to his world tours, educational philosophy, and recording and pedagogical legacy, Starker takes the reader on a riveting, entertaining, and informative journey. Included in the book are several of Starker's short stories and commentaries on world events, academia, and—of course—music that have appeared in newspapers, music periodicals, and trade magazines.Also includes a bonus CD recording of Starker's last public recital, which is unavailable commercially and includes his only recording of the Strauss Sonata in F, Opus 6.Included on the CD:Richard Strauss, Sonata in F, Opus 6Ludwig van Beethoven, Sonata in C major, Opus 102 no. 1Johannes Brahms, Sonata in E minor, Opus 38Franz Schubert, Sonatina in D, Opus 137 no. 1 (Starker edition)

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An urgent primer on what can be done to combat emerging threats to the core of U.S. Democracy—presidential elections.In 2000, we learned that an exceptionally close presidential election can produce chaos, because we have no reliable Constitutional mechanism for resolving disputes. Joe Biden just won a presidential election that was extremely close in a number of states. Trump—and his many supporters—refuse to accept the legitimacy of those vote results, leading to an insurrection at the Capitol Building. Where do we go from here?In A Short History, Constitutional scholar Alan Hirsch presents a concise history of presidential elections that resulted in crises and advocates clear, common-sense solutions, including abolishing the Electoral College and the creation of a permanent, non-partisan Presidential Election Review Board to prevent or remedy future crises.“Hirsch does a very good job of offering historical context to illuminate the present—and the terrifying future. His imaginative proposals are probably too sensible to be implemented in an age of parochial partisanship.”—David Shipler, former reporter for the New York Times and Pulitzer Prize winner“Democracy is broken, but as Alan Hirsch explains, it really doesn’t have to be. This is the real story of how our voting system became so vulnerable to attacks from within and without, told with precision, verve, and even hope. This is the way out.”—Douglas Rushkoff, author of Team Human“This is a must-read for anyone who cares about safeguarding presidential elections―which should be everyone.”—Evan Caminker, Professor and former Dean, University of Michigan Law School"The noted law historian, author of Impeaching the President, examines the handful of seriously problematic presidential elections in American history and what the Constitution elucidates about the process of undoing such an event—namely, nothing. . . . A highly relevant study featuring much food for thought and prospects for change."—Kirkus Reviews, Starred Review" [A] seminal work of meticulous and informative scholarship that should be considered as an essential and unreservedly recommended addition to community, college, and university library Contemporary Political Science collections. It should be noted for the personal reading lists of students, academia, political activists, and non-specialist general readers with an interest in the subject."—Midwest Library Review

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This book is the companion to "Unfolding Stakeholder Thinking: Theory, Responsibility and Engagement", which examined many emerging theoretical and normative issues and was released to acclaim in October 2002. "Unfolding Stakeholder Thinking 2" collects a series of essays by leading researchers worldwide to focus on the practice of stakeholder engagement in terms of relationship management, communication, reporting and performance. As stakeholder relationships and business in society have become increasingly central to the unfolding of stakeholder thinking, important new topics have begun to take centre stage in both the worlds of practice and academia. The first part of the book makes clear that simply engaging with stakeholders is insufficient to build successful stakeholder strategies. Companies, considered as the focal entity in a relationship, also need to actively communicate with stakeholders and manage their relationships. Dialogue is essential but can only be useful if companies listen to the messages that stakeholders are sending them. It is also essential to understand the role of power and influence in stakeholder engagement strategies especially if partnerships or collaborations emerge from the relationships that are engendered. The book examines a wide range of corporate–NGO collaborations to determine what makes them effective – and what makes them fail. Conflict management in stakeholder alliances is also discussed. The second part of the book addresses the critically important element of emerging schemes for the assessment, measurement and reporting of business in society and relationships involving stakeholders. A variety of current approaches to stakeholder assessment and reporting are discussed here including social auditing and sustainability reporting. The evolution of stakeholder thinking has led to a new view of the firm as an organism embedded in a complex web of relationships with other organisms. The role of management becomes immensely more challenging, when stakeholders are no longer seen as simply the objects of managerial action but rather as subjects with their own objectives and purposes. This book captures the complexity of managing relationships with stakeholders and will provide both practitioners and researchers with a wealth of information on the benefits and consequences of this practice.

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This book is a strong piece of scholarship and its contributors, among the best in the field, must be commended. They have achieved their goal to establish interculturalism as a new paradigm for diversity management. By the same token, they have provided governments, cities and academia with a possible alternative to multiculturalism (a term which is declining in favour in Europe). I have no doubt that the book, with its welcome combination of theoretical and empirical inputs, will soon become a milestone.'- Gérard Bouchard, Université du Québec à Chicoutimi, Canada'This excellent collection of uniformly high quality essays analyses the theory, policy and implementation of the increasingly popular idea of interculturalism, and shows how it offers the best way to integrate minorities at the local level. It is underpinned by a well worked out theoretical framework and embedded in rich empirical analysis.'- Bhikhu Parekh, University of Westminster and Member of the House of Lords, UKCities are increasingly recognized as new players in diversity studies, and many of them are showing evidence of an intercultural shift. As an emerging concept and policy, interculturalism is becoming the most pragmatic answer to concrete concerns in cities. Within this framework, this book covers two major concerns: how to conceptualize and how to implement intercultural policies.Through the use of theoretical and comparative case studies, the current most prominent contributors in the field examine an area that multicultural policies have missed in the past: interaction between people from different cultures and national backgrounds. By compiling the recent research in Europe and elsewhere this book concludes that interculturalism is becoming both an attractive and efficient new paradigm for diversity management.Academics, students and researchers working in the field of diversity studies and related areas will find this to be an essential read. Taking an innovative approach to issues raised by interculturalism in cities, it will also appeal to policy makers seeking to formulate a new policy focus and approaches for diversity management.Contributors: T. Cantle, T. Caponio, I. Guidikova, A. Harell, A. Ludwinek, R. Ricucci, F. Rocher, A. Triandafyllidou, I. Ulasiuk, A. Wagner, P. Wood, R. Zapata-Barrero

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Now widely adopted on courses throughout the world, the prestigious Nutrition Society Textbook series provides students with the scientific basics in nutrition in the context of a systems and disease approach rather than on a nutrient by nutrient basis. In addition books provide a means to enable teachers and students to explore the core principles of nutrition and to apply these throughout their training to foster critical thinking at all times. This NS Textbook on Sport and Exercise Nutrition has been written to cover the latest information on the science and practice of sport and exercise nutrition. A key concept behind this textbook is that it aims to combine the viewpoints of world leading nutrition experts from both academia/research and a practical stand point. Plus where necessary there are additional practitioner based authors to ensure theory is translated into practice for each chapter in the form of either ‘practice tips' or ‘information sheets' at the end of relevant chapters. The textbook in essence can be divided into three distinct but integrated parts: Part 1: covers the key components of the science that supports the practice of sport and exercise nutrition including comprehensive reviews on: nutrients both in general and as exercise fuels; exercise physiology; hydration, micronutrients; and supplements. Part 2: moves into focusing on specific nutrition strategies to support different types of training including: resistance; power/sprint; middle distance/speed endurance; endurance; technical/skill, team; and specific competition nutrition needs. The unique format of this textbook is that it breaks down nutrition support into training specific as opposed to the traditional sport specific support. This reflects the majority of current sport and exercise requirements of the need to undertake concurrent training and therefore facilitating targeted nutrition support to the different training components through the various macro and micro training cycles. Part 3: explores some of the practical issues encountered in working in the sport and exercise nutrition field and includes key sport related topics such as: disability sport; weight management; eating disorders; bone and gut health; immunity; injury; travel; and special populations and situations. READERSHIP: Students of nutrition and dietetics at both undergraduate and postgraduate level. All those working in the field of nutrition and related health sciences.

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ROADMAPPING EXTENDED REALITY This book offers a comprehensive overview of the technological aspects of Extended Realities (XR) and discusses the main challenges and future directions in the field. This book is important and timely – XR technologies have overcome the 3 main aspects that were holding it back from mainstream adoption: cost, cables, and size. However, there are many aspects of XR technologies that are now going to be explored and developed that still need urgent research in terms of security, privacy, health and safety, long-term effects, addiction risks, and age-related developmental concerns, and the aim of the book is to inform all readers of these open issues and challenges. There are currently a great number of interdisciplinary researchers and developers working in the XR R&D field. Recently, XR technologies moved from the Gartner Hype Cycle onto the Plateau of Productivity on the Gartner Hype Cycle signaling that the fundamental XR technologies are now deemed mature technologies and ready for deployment in a wide variety of application areas. Corroborated by the fact that XR technologies are part of the future Metaverse, a concept that went rapidly mainstream during the time of writing of this book. Roadmapping Extended Reality is divided into two parts: (1) fundamentals and (2) applications. The first part covers the main technological aspects of XR. The chapters in this section review and discuss relevant fundamental concepts of XR, the actual state-of-the-art, and future challenges. The second part of the book focuses on covering a wide range of applications of XR including a future roadmap. All in all, the book offers a snapshot of the state-of-the-art in XR and addresses the needs of a multidisciplinary audience working in both academia and the industry, as well as stakeholders at government agencies and non-profit organizations. Audience This book is aimed at academic and industrial developers, exploring and developing applications in the XR, VR, AR, AI, smart IoT, 4th Industrial Revolution space, including those that are solving technology requirements, human factors, evaluation methodology advances, and ROI investigations.

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PRODUCT INNOVATION TOOLBOX Discover how to implement consumer-centric innovation to help create new product development in this latest edition In recent years, behavioral approaches, social media listening, and other new techniques and technologies—digital techniques, augmented intelligence, machine learning, and advanced biometrics, among others—have been foregrounded in innovation research. A focus on the evolving fields of data science and neuroscience is a driving force for both researchers and the people they study. These digital and mobile technologies have enabled researchers to augment listening, observing and categorizing methods, and to adapt new techniques in attempting to better understand consumers. On the other hand, digitized mobile societies, spurred by faster and cheaper internet access, emphasize an interconnectedness that drastically alters human behaviors and creates borderless influences. Even so, the tenets and approaches to insightful deep learning for consumers and other actors, from discovery through to the launch of successful products, remains an intrinsic part of assessing the market. Product Innovation Toolbox brings together key thought leaders and seasoned consumer researchers from corporate R&D, academia, and marketing research companies to share their experiences, advanced consumer research tools and practical tips for successful and sustainable product innovation. By offering these leading-edge tools and insights, the book ensures consumer-centric innovation by linking strategy and a designed approach. The new edition focuses on the integration and connection of all data—both structured and unstructured???for deep learning and activation, rather than a differentiated qualitative—quantitative approach, reflecting the shifting relationships involved in the latest developments in the field. The second edition of Product Innovation Toolbox also includes: Revised material for more than 70% of the manual, with 11 new and extensively updated chapters New tools sections on digital technologies to create novel ways to stimulate and elicit insights from participants, such as Virtual Reality (VR) and Digital Augmentation Upgraded versions of tools in each updated section, with fresh examples New case studies created using the tools from the previous edition, including cases regarding cross-continental marketplaces and cross-cultural societies An emphasis on tools with global applications Product Innovation Toolbox is an essential resource for product developers, marketers, and technologists.

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Antitrust is a sledgehammer to the creation of European-wide markets. How does it really work though? Take the case of power contracting. Look at the smart and fresh view from a promising scholar: Adrien de Hauteclocque. A must read.'- Jean-Michel Glachant, European University Institute, Italy'Long-term energy contracts pose one of the greatest challenges for EU competition law. Focusing on electricity markets and contracts, this book provides interesting new approaches and guidance in this area of EU law. The book also examines a wider and even more difficult issue: what role can competition law have in creating markets. The book delivers. It is a remarkably lucid account of difficult issues. A must-have book for practitioners and policy makers alike.'- Kim Talus, University of Eastern FinlandMarket Building through Antitrust investigates the role of antitrust policy in the building of competitive energy markets in Europe.By looking at the specific problem of long-term supply and access contracts in the electricity sector, the book questions the suitability of antitrust policy as a market building tool. It shows that the institutional infrastructure that pre-dated competitive reform and the politics of liberalization have largely shaped the current dynamics at work in European energy regulatory practice. In particular, antitrust law has increasingly been used as a quasi-ex ante regulatory tool, thereby raising problems in terms of economic efficiency, legal certainty and political legitimacy.By mixing legal, political and economic perspectives, this book will appeal to a wide range of readers from academia in law, economics and political science, regulatory and competition authorities, as well as legal and consulting practices and business economists.Contents: Foreword General Introduction 1. The Problem of Long-term Contracts in Decentralized Electricity Markets: An Economic Perspective 2. Vertical De-integration and Single Market Integration in the European Union: An Incomplete Transition 3. The Antitrust Strategy of the European Commission on Long-term Contracts: Is the New Methodology truly 'More Economic'? 4. Long-term Contracts Across Member States: The Problem of Priority Access Rights to Interconnectors 5. The Strategy of the European Union for the Development of Interconnectors: Assessing the Role of Merchant Transmission Investment with Vincent Rious Bibliography Index

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Providing Internet services to mobile users has become the most significant topic within the telecommunications research community in the past few years. As a result several books have been published by the experts from the cellular communications world and researchers from the computer science field. While cellular books cover architecture and air interface of the second- and third-generation wireless systems, computer networks and Internet books overview some fundamentals and protocols on migrating the fix-IP into mobile environment. Other books that claimed to cover the both topics in the past, however, also failed to provide a complete literature on wireless IP, because of focusing on either access technology or network protocols. The Wireless Mobile Internet - Architectures, Protocols, and Services elegantly bridges this gap and therefore provides the first complete literature for the wireless Internet both describing the standard activities and the current status of the wireless IP, as well as detailing network models and specific techniques. While some chapters in the Wireless Mobile Internet describe the standard activities and the current status of the wireless IP other chapters detail network models and specific techniques that usually approached by academic researchers. * Comprehensive yet simple understanding of the wireless Internet through usage of more than 250 conceptual and numerical result figures * Logical organization for customized use as a reference book on the state-of-the-art technology for wireless Internet, a text for fundamental components of the wireless Internet, standards, and a guideline for advanced research topics * Provides an easy-to-read but complete reference for core network and access technology of 2G and 3G cellular systems as well as related standards * Illustrates the main features of future mobile networks * Offers a thorough literature on essentials for a mobile network: quality of service, traffic modelling and management, mobility management, transport protocols, and network protocols * Uniquely covers all relevant telecommunication access and network technologies for wireless Internet from wireless LAN to satellite Essential reading for researchers from industry and academia in the field of wireless cellular networks and Internet, practicing engineers who need a single text on the subject as well as senior level undergraduates and first-year postgraduates.

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Research and development on liquid crystal display (LCD) backlight technologies are becoming increasingly important due to the fast growth of the LCD business. Backlight technologies contribute to functional improvements of LCDs in terms of wide colour reproduction, uniformity improvements of luminance and colour temperature, high luminance, long life, less power consumption, thinner backlight unit, as well as cost. As LCD panel technology progresses, the lighting technology that provides the illumination for the panel must similarly evolve. LCD Backlights is written by a global panel of leading researchers and practitioners in this field from both academia and industry. The first part of LCD Backlights details the variety of applications of backlights including those in LCD-TV, PC monitors and mobile devices. The second part is a full examination of the different light sources that are used including the latest technological trends in amongst others, cold cathode fluorescent lamps (CCFLs), mercury-free fluorescent lamps and light emitting diodes (LEDs). The final part of the book analyses the optical component of backlights such as diffusers and brightness enhancement films. Key features: Provides a comprehensive analysis of the latest status of LCD backlight research and development. Discusses the design considerations and technical requirements for the multiple applications of LCD backlights. Considers techniques used for power saving and picture quality improvement. Examines the requirements for backlight units used for TVs, PC monitors and mobile phones. LCD Backlights is of significant interest to practising electronics and display engineers as well as scientists working on the development of liquid crystal displays. This book is also of value to graduate students and researchers involved in display technologies. The Society for Information Display (SID) is an international society, which has the aim of encouraging the development of all aspects of the field of information display. Complementary to the aims of the society, the Wiley-SID series is intended to explain the latest developments in information display technology at a professional level. The broad scope of the series addresses all facets of information displays from technical aspects through systems and prototypes to standards and ergonomics

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The desire to build lower cost analog front-ends has triggered interest in a new domain of research. Consequently the joint design of the analog front-end and of the digital baseband algorithms has become an important field of research. It enables the wireless systems and chip designers to more effectively trade the communication performance with the production cost. Digital Compensation for Analog Front-Ends provides a systematic approach to designing a digital communication system. It covers in detail the digital compensation of many non-idealities, for a wide class of emerging broadband standards and with a system approach in the design of the receiver algorithms. In particular, system strategies for joint estimation of synchronization and front-end non-ideality parameters are emphasized. The book is organized to allow the reader to gradually absorb the important information and vast quantity of material on this subject. The first chapter is a comprehensive introduction to the emerging wireless standards which is followed by a detailed description of the front-end non-idealities in chapter two. Chapter three then uses this information to explore what happens when the topics introduced in the first two chapters are merged. The book concludes with two chapters providing an in-depth coverage of the estimation and compensation algorithms. This book is a valuable reference for wireless system architects and chip designers as well as engineers or managers in system design and development. It will also be of interest to researchers in industry and academia, graduate students and wireless network operators. Presents a global, systematic approach to the joint design of the analog front-end compensation, channel estimation, synchronization and of the digital baseband algorithms Describes in depth the main front-end non-idealities such as phase noise, IQ imbalance, non-linearity, clipping, quantization, carrier frequency offset, sampling clock offset and their impact on the modulation Explains how the non-idealities introduced by the analog front-end elements can be compensated digitally Methodologies are applied to the emerging Wireless Local Area Network and outdoor Cellular communication systems, hence covering OFDM(A), SC-FDE and MIMO Written by authors with in-depth expertise developed in the wireless research group of IMEC and projects covering the main broadband wireless standards

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A very high portion of the seafood we eat comes from abroad, mainly from China and Southeast Asia, and most of the active ingredients in medicines we take originate in other countries. Many low- and middle-income countries have lower labor costs and fewer and less stringent environmental regulations than the United States, making them attractive places to produce food and chemical ingredients for export. Safe Foods and Medical Products Through Stronger Regulatory Systems Abroad explains that the diversity and scale of imports makes it impractical for U.S. Food and Drug Administration (FDA) border inspections to be sufficient to ensure product purity and safety, and incidents such as American deaths due to adulterated heparin imported from China propelled the problem into public awareness. The Institute of Medicine Committee on Strengthening Core Elements of Regulatory Systems in Developing Countries took up the vital task of helping the FDA to cope with the reality that so much of the food, drugs, biologics, and medical products consumed in the United States originate in countries with less-robust regulatory systems. Ensuring Safe Foods and Medical Products Through Stronger Regulatory Systems Abroad describes the ways the United States can help strengthen regulatory systems in low and middle income countries and promote cross-border partnerships - including government, industry, and academia - to foster regulatory science and build a core of regulatory professionals. This report also emphasizes an array of practical approaches to ensure sound regulatory practices in today's interconnected world. Table of Contents Front Matter Summary 1 Introduction 2 Core Elements of Regulatory Systems 3 Critical Issues 4 A Strategy to Building Food and Medical Product Regulatory Systems 5 International Action 6 Domestic Action 7 Conclusions and Priorities Appendix A: Glossary Appendix B: A Review of Tort Liability's Role in Food and Medical Product Regulation Appendix C: Food and Medical Product Regulatory Systems of South Africa, Brazil, India, and China Appendix D: Chinese Food Regulatory System Appendix E: Meeting Agendas Appendix F: Committee Member Biographies Appendix G: Analyzing Food Safety Alerts in European Union Rapid Alerts Systems for Food and Feed Appendix H: Strengthening Core Elements of Regulatory Systems in Developing Countries: Identifying Priorities and an Appropriate Role for the U.S. Food and Drug Administration

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The bestselling historian and journalist James Rosen provides the first comprehensive account of the brilliant and combative Supreme Court justice Antonin Scalia, whose philosophy and judicial opinions defined our legal era. With SCALIA: Rise to Greatness, 1936–1986, the opening instalment in a two-volume biography, acclaimed reporter and bestselling historian James Rosen provides the first comprehensive account of the life of Justice Antonin Scalia, whose singular career in government—including three decades on the Supreme Court—shaped American law and society in the twenty-first century. A decade in the making, Rise to Greatness tells the story of the kid from Queens who became the first Italian American on the Court and one of the most profoundly influential figures of our time. This volume takes us from Scalia’s birth to his ascension to the Court, providing a fresh and probing look at his Catholic upbringing and education; his stints in academia and published works, some of them obscure and long-overlooked; and his service in the Nixon and Ford administrations, when Scalia played a central role in reforming the U.S. intelligence community and in the approval of sensitive covert operations. Deeply researched and based on unparalleled access to documentary and personal sources, and written with an intellectual rigor and wit befitting its subject, Rosen’s narrative reads like a novel while presenting startling new insight into the life, mind, career, faith, and legacy of the man whom family and friends called “Nino.” The result is a compelling portrait of an American legend with whom the author personally corresponded, broke bread, drank wine, and braved the streets of the capital as a (nervous) passenger in the justice’s famously speedy BMW. Rosen has unearthed previously unpublished writing from every phase of Scalia’s career, including private Supreme Court emails, and has interviewed Scalia’s family, classmates, students, colleagues from the Nixon, Ford, and Reagan administrations, priests, poker buddies, hunting companions, and fellow judges and justices. Rise to Greatness is a landmark of modern biography, a rich and moving study, accessible to lay readers, that brings to life a towering figure of American history. It is the book Scalia fans, and all citizens interested in history and the law, have long awaited.

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Cradled among the world's highest mountains - and sheltering one of its most devout religious communities - Tibet is, for many of us, an ultimate destination, a place that touches the heavens, a place only barely in our world, at its very end. In recent decades Western fascination with Tibet has soared, from the rise of Tibetan studies in academia to the rock concerts aimed at supporting its independence to the simple fact that most of us know - far from any base camp - exactly what a sherpa is. And yet any sustained look into Tibet as a place, any attempt to find one's way around its high plateaus and through its deep history, will yield this surprising fact: we have barely mapped it. With this atlas, Karl E. Ryavec rights that wrong, sweeping aside the image of Tibet as Shangri-La and putting in its place a comprehensive vision of the region as it really is, a civilization in its own right. And the results are absolutely stunning. The product of twelve years of research and eight more of mapmaking, A Historical Atlas of Tibet documents cultural and religious sites across the Tibetan Plateau and its bordering regions from the Paleolithic and Neolithic times all the way up to today. It ranges through the five main periods in Tibetan history, offering introductory maps of each followed by details of western, central, and eastern regions. It beautifully visualizes the history of Tibetan Buddhism, tracing its spread throughout Asia, with thousands of temples mapped, both within Tibet and across North China and Mongolia, all the way to Beijing. There are maps of major polities and their territorial administrations, as well as of the kingdoms of Guge and Purang in western Tibet, and of Derge and Nangchen in Kham. There are town plans of Lhasa and maps that focus on history and language, on population, natural resources, and contemporary politics. Extraordinarily comprehensive and absolutely gorgeous, this overdue volume will be a cornerstone in cartography, Asian studies, Buddhist studies, and in the libraries or on the coffee tables of anyone who has ever felt the draw of the landscapes, people, and cultures of the highest place on Earth.

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AN INSTANT NEW YORK TIMES, USA TODAY, AND AMAZON BESTSELLER America’s most effective conservative intellectual proves once and for all that Marxist radicals have taken over our nation's institutions.In the 1960s, Mao launched China’s Cultural Revolution. Cities grew overcrowded. Technocrats demanded progress from above. Anyone opposed was sent to be “re-educated.” China’s revolution was bloody, fast, and a failure, but what if America started a revolution at the same time, based on the same bad ideas, and it’s just been slower, calmer, and more effective?In his powerful new book, Christopher F. Rufo uncovers the hidden history of left-wing intellectuals and activists who systematically took control of America’s institutions to undermine them from within. America’s Cultural Revolution finally answers so many of the questions normal Americans have, such as:• Why is nearly every major corporation bending the knee to a far-left agenda?• How did DEI suddenly become the department no institution can continue without?• Why is race the main thing America’s rich, white elite wants to talk about? • When did the left adopt all this doublespeak, saying progress is a lack of progress, equality is not equality, speech is violence, and violence is speech?• Has the goal of the left, for a century, actually been the destruction of every Western institution? Readers may not know the names of Herbert Marcuse, Angela Davis, Paulo Freire, and Derrick Bell, but they will recognize the ideas they spread. How their radical, destructive ideology slowly worked its way from prisons to academia to classrooms to your human resources department will come as a shock.Failing to act soon, Rufo warns, could allow the radical left to achieve their ultimate objective: replacing constitutional equality with a race-based redistribution system overseen by bureaucratic ‘diversity and inclusion’ officials. Most Americans don’t want this, but most Americans are no longer in control of our institutions. If the mainstream media’s depiction of a failing dystopia in need of a fresh start never sounded right to you, this expose and call to arms is the book you’ve been looking for.

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In the 1980’s sonochemistry was considered to be a rather restricted branch of chemistry involving the ways in which ultrasound could improve synthetic procedures, predominantly in heterogeneous systems and particularly for organometallic reactions. Within a few years the subject began to expand into other disciplines including food technology, environmental protection and the extraction of natural materials. Scientific interest grew and led to the formation of the European Society of Sonochemistry in 1990 and the launch of a new journal Ultrasonics Sonochemistry in 1994. The subject continues to develop as an exciting and multi-disciplinary science with the participation of not only chemists but also physicists, engineers and biologists. The resulting cross-fertilisation of ideas has led to the rapid growth of interdisciplinary research and provided an ideal way for young researchers to expand their knowledge and appreciation of the ways in which different sciences can interact. It expands scientific knowledge through an opening of the closed doors that sometimes restrict the more specialist sciences. The journey of exploration in sonochemistry and its expansion into new fields of science and engineering is recounted in "Sonochemistry Evolution and Expansion" written by two pioneers in the field. It is unlike other texts about sonochemistry in that it follows the chronological developments in several very different applications of sonochemistry through the research experiences of the two authors Tim Mason and Mircea Vinatoru. Designed for chemists and chemical engineers Written by two experts and practitioners in the subject Volume 1 covers the historical background and evolution of sonochemistry Volume 2 explains the wider applications and expansion of the subject VOLUME 2 Applications and Developments Volume 2 contains six chapters which detail the developments of sonochemistry in fields which continue to attract considerable research and development interest from academia and industry. The topics range from the important developments in chemical synthesis through food technology and materials processing to therapeutic ultrasound. The authors have made contributions to all of these and so the content is written in a way which should be understandable to readers whose expertise may not necessarily be in the individual topic. Each of the applications and developments described help to illustrate not only the diverse nature of sonochemistry but also the unifying theme of the effects of acoustic cavitation on a wide range of procedures.

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This excellent book covers the important legal and political perspectives on the world's freshwater resources. The chapters, written by distinguished experts from academia and practice, systematically address issues of economics, environment, sovereignty over resources, energy, conflict resolution, and in addition offer some in depth case studies. A wonderful book and compulsory reading for who needs to have the full picture of the complex international dynamics of freshwater in our time.'- Catherine Brölmann, University of Amsterdam, The Netherlands'In sum, the volume is a must for all those who know and practice international and domestic water law, who influence the international water governance debate at the global, regional, and sub-regional scales, and who, in general, interact with water resources in the transboundary but also in the domestic setting of their respective countries.'- Stefano Burchi, Chairman of the International Association for Water Law - AIDA'International Law and Freshwater is an outstanding piece of legal and policy scholarship that poignantly, thoughtfully and effectively addresses the who, what, where, when and how of international waters governance and international law.'- Richard Kyle Paisley, University of British Columbia, CanadaThe issues surrounding water embody some of the greatest challenges of the 21st century. The editors of this timely book have brought together the leading authors in the field to explore the key questions involving international law and water governance.International Law and Freshwater connects recent legal developments through the breadth and synergies of a multidisciplinary analysis. It addresses such critical issues as water security, the right to water, international cooperation and dispute resolution, State succession to transboundary watercourse treaties, and facets of international economic law, including trade in 'virtual water' and the impacts of 'land grabs'.Containing detailed analysis and thought-provoking solutions, this book will appeal to researchers and academics working in the legal field, as well as international relations and natural sciences. Water practitioners, public officials, diplomats and students will also find much to interest them in this insightful study.Contributors: A.S. Al-Khasawneh, U. Alam, L. Boisson de Chazournes, L. Caflisch, M. Claassen, C. de Albuquerque, G. de los Cobos, L. del Castillo-Laborde, D. Garrick, J. Granit, D. Grey, E. Hey, V. Hughes, M. Kohen, C. Leb, G. Marceau, M.M. Mbengue, S.C. McCaffrey, O. McIntyre, S.M.A. Salman, D. Shelton, A. Tanzi, M. Tignino, B.A. Yimer

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An empowering guide for students in STEMM that demystifies the process of securing undergraduate research experiences. Conducting research is an important foundation for many undergraduates on STEMM career paths. But landing an extremely competitive research spot that is also an enriching experience involves knowing how to present yourself effectively and an awareness of your goals and expectations. In this book, an expert lab manager and a longtime principal investigator share their secrets for obtaining these coveted positions. Offering advice to students in a wide variety of STEMM fields at both research-intensive universities and primarily undergraduate institutions, Getting In helps students navigate the hidden curriculum of academia, unofficial rules that disproportionately affect first-generation college students and those from low-income backgrounds and communities historically underrepresented in science. The authors provide not only an overview of STEMM research and lab opportunities but also specific strategies for the entire application process—including how to write emails that get noticed by busy professors, how to ask for a research position during office hours, and interview questions to prepare for—so students can claim their place in research settings. With its emphasis on the many interpersonal and professional benefits of research experiences, Getting In equips all STEMM undergrads with the tools they need both to secure these valued positions and to develop habits that will build productive relationships with their future research mentors.As an undergrad, Getting In will help you: determine how much time you can spend on research by evaluating your current activity level and goals. find the time to do research without giving up your social life or risking your GPA. avoid common mistakes in the search, application, or interview that make it harder to find a research experience. write emails that get you noticed by busy professors by customizing the included templates. prepare for tough interview questions so you’ll impress the interviewer with your answers, and be able to determine if the position is right for you. As a research mentor, Getting In will help your students: navigate the hidden curriculum of finding a research experience in science, technology, engineering, math, and medicine (STEMM). set realistic expectations for their research experience. understand why conducting research requires effort and will include some failure and other challenges. be active participants in their success in the lab.

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This monograph is intended to present an overview- most of which is based on ideas and conclusions presented in published literature, the rest representing our own concepts developed through extensive research. Here, the reader will discover the rational relationships between basic mechanisms, and experimental data, and theoretical expressions which were developed over several years by scientists for coir fibre characterisation and utilisation in particular. It will help to those who deal with coir fibre in both industry and academia specially to teachers, students and technologists. It contains the perspective of coir, its textile related structure and properties with a comparison between few other allied lingo-cellulosic fibres. Coir fibre are coarser for textile applications and possesses highly variable properties. So segregation of fibres from the bulk considering properties may give suitable fibre for spinning, composite making and other applications. The optimum value addition of coir can be realized, when a fully systematic supply chain of quality fibre with proper gradation system can be developed. The fibre shows high flexural rigidity and lower inter-fibre frictional resistance for which it is difficult to spin finer yarn and indicates its suitability for coarse textile applications. Coir fibre is circular and multi-fibrillar. Moisture regain is moderate. Thermal and component analyses reveal the presence of similar amount of lignin and celluloses in the fibre. SEM image reveals that surface of the fibre is waxy, irregular, and having micro-imperfections. Microbial resistance makes the coir suitable for using it in different engineering and geotechnical applications in conjunction with soil and water. The property-based advantages of coir are resistant to fungi and rot, excellent insulation against temperature, not easily combustible, flame-retardant, resistant to moisture and dampness, tough and durable, highly resilient, totally static free, easy to clean etc. It is not suitable for technical uses due to low strength, high extensibility and very low modulus. Sometimes high bulk and low coefficient of friction act as the disadvantages. The age old manual spinning technology should be replaced by mechanised system. The fibres can be highly suitable to form compressed mat for various products of geotextile, agro-textiles, and sound and heat insulators with improved softness and fineness property. Being an ecofriendly, natural product from renewable sources, coir products serve mankind in several ways as a substitute for many synthetic products which are extensively used but are harmful to nature. Coir wood substitute will help to protect valuable forests.

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Behavioral nudges are everywhere: calorie counts on menus, automated text reminders to encourage medication adherence, a reminder bell when a driver's seatbelt isn't fastened. Designed to help people make better health choices, these reminders have become so commonplace that they often go unnoticed. In Nudging Health, forty-five experts in behavioral science and health policy from across academia, government, and private industry come together to explore whether and how these tools are effective in improving health outcomes. Behavioral science has swept the fields of economics and law through the study of nudges, cognitive biases, and decisional heuristics-but it has only recently begun to impact the conversation on health care. Nudging Health wrestles with some of the thorny philosophical issues, legal limits, and conceptual questions raised by behavioral science as applied to health law and policy. The volume frames the fundamental issues surrounding health nudges by addressing ethical questions. Does cost-sharing for health expenditures cause patients to make poor decisions? Is it right to make it difficult for people to opt out of having their organs harvested for donation when they die? Are behavioral nudges paternalistic? The contributors examine specific applications of behavioral science, including efforts to address health care costs, improve vaccination rates, and encourage better decision-making by physicians. They wrestle with questions regarding the doctor-patient relationship and defaults in healthcare while engaging with larger, timely questions of healthcare reform. Nudging Health is the first multi-voiced assessment of behavioral economics and health law to span such a wide array of issues-from the Affordable Care Act to prescription drugs. Contributors: David A. Asch, Jerry Avorn, Jennifer Blumenthal-Barby, Alexander M. Capron, Niteesh K. Choudhry, I. Glenn Cohen, Sarah Conly, Gregory Curfman, Khaled El Emam, Barbara J. Evans, Nir Eyal, Andrea Freeman, Alan M. Garber, Jonathan Gingerich, Michael Hallsworth, Jim Hawkins, David Huffman, David A. Hyman, Julika Kaplan, Aaron S. Kesselheim, Nina A. Kohn, Russell Korobkin, Jeffrey T. Kullgren, Matthew J.B. Lawrence, George Loewenstein, Holly Fernandez Lynch, Ester Moher, Abigail R. Moncrieff, David Orentlicher, Manisha Padi, Christopher T. Robertson, Ameet Sarpatwari, Aditi P. Sen, Neel Shah, Zainab Shipchandler, Anna D. Sinaiko, Donna Spruijt-Metz, Cass R. Sunstein, Thomas S. Ulen, Kristen Underhill, Kevin G. Volpp, Mark D. White, David V. Yokum, Jennifer L. Zamzow, Richard J. Zeckhauser

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AN AUTHORITATIVE GUIDE THAT EXPLAINS THE EFFECTIVENESS AND IMPLEMENTATION OF BOW TIE ANALYSIS, A QUALITATIVE RISK ASSESSMENT AND BARRIER MANAGEMENT METHODOLOGY From a collaborative effort of the Center for Chemical Process Safety (CCPS) and the Energy Institute (EI) comes an invaluable book that puts the focus on a specific qualitative risk management methodology – bow tie barrier analysis. The book contains practical advice for conducting an effective bow tie analysis and offers guidance for creating bow tie diagrams for process safety and risk management. Bow Ties in Risk Management clearly shows how bow tie analysis and diagrams fit into an overall process safety and risk management framework. Implementing the methods outlined in this book will improve the quality of bow tie analysis and bow tie diagrams across an organization and the industry. This important guide: Explains the proven concept of bow tie barrier analysis for the preventing and mitigation of incident pathways, especially related to major accidents Shows how to avoid common pitfalls and is filled with real-world examples Explains the practical application of the bow tie method throughout an organization Reveals how to treat human and organizational factors in a sound and practical manner Includes additional material available online Although this book is written primarily for anyone involved with or responsible for managing process safety risks, this book is applicable to anyone using bow tie risk management practices in other safety and environmental or Enterprise Risk Management applications. It is designed for a wide audience, from beginners with little to no background in barrier management, to experienced professionals who may already be familiar with bow ties, their elements, the methodology, and their relation to risk management. The missions of both the CCPS and EI include developing and disseminating knowledge, skills, and good practices to protect people, property and the environment by bringing the best knowledge and practices to industry, academia, governments and the public around the world through collective wisdom, tools, training and expertise. The CCPS has been at the forefront of documenting and sharing important process safety risk assessment methodologies for more than 30 years. The EI's Technical Work Program addresses the depth and breadth of the energy sector, from fuels and fuels distribution to health and safety, sustainability and the environment. The EI program provides cost-effective, value-adding knowledge on key current and future international issues affecting those in the energy sector.

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One approach to organic synthesis is retrosynthetic analysis. With this approach chemists start with the structures of their target molecules and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This “disconnection” approach to synthesis is now a fundamental part of every organic synthesis course. Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition This workbook provides a comprehensive graded set of problems to illustrate and develop the themes of each of the chapters in the textbook Organic Synthesis: The Disconnection Approach, 2nd Edition. Each problem is followed by a fully explained solution and discussion. The examples extend the student’s experience of the types of molecules being synthesised by organic chemists, and the strategies they employ to control their syntheses. By working through these examples students will develop their skills in analysing synthetic challenges, and build a toolkit of strategies for planning new syntheses. Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given. Together the workbook and textbook provide a complete course in retrosynthetic analysis. Organic Synthesis: The Disconnection Approach, 2nd Edition There are forty chapters in Organic Synthesis: The Disconnection Approach, 2nd Edition: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems. In its second edition updated examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, Organic Synthesis: Strategy and Control. Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry. Workbook for Organic Synthesis: The Disconnection Approach, 2nd edition, combined with the main textbook, provides a full course in retrosynthetic analysis for chemistry and biochemistry students, and a refresher course for organic chemists working in industry and academia.

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Electrochemistry is a discipline of wide scientific and technological interest. Scientifically, it explores the electrical properties of materials and especially the interfaces between different kinds of matter. Technologically, electrochemistry touches our lives in many ways that few fully appreciate; for example, materials as diverse as aluminum, nylon, and bleach are manufactured electrochemically, while the batteries that power all manner of appliances, vehicles, and devices are the products of electrochemical research. Other realms in which electrochemical science plays a crucial role include corrosion, the disinfection of water, neurophysiology, sensors, energy storage, semiconductors, the physics of thunderstorms, biomedical analysis, and so on. This book treats electrochemistry as a science in its own right, albeit resting firmly on foundations provided by chemistry, physics, and mathematics. Early chapters discuss the electrical and chemical properties of materials from which electrochemical cells are constructed. The behavior of such cells is addressed in later chapters, with emphasis on the electrodes and the reactions that occur on their surfaces. The role of transport to and from electrodes is a topic that commands attention, because it crucially determines cell efficiency. Final chapters deal with voltammetry, the methodology used to investigate electrode behavior. Interspersed among the more fundamental chapters are chapters devoted to applications of electrochemistry: electrosynthesis, power sources, “green electrochemistry”, and corrosion. Electrochemical Science and Technology is addressed to all who have a need to come to grips with the fundamentals of electrochemistry and to learn about some of its applications. It will constitute a text for a senior undergraduate or graduate course in electrochemistry. It also serves as a source of material of interest to scientists and technologists in various fields throughout academia, industry, and government – chemists, physicists, engineers, environmentalists, materials scientists, biologists, and those in related endeavors. This book: Provides a background to electrochemistry, as well as treating the topic itself. Is accessible to all with a foundation in physical science, not solely to chemists. Is addressed both to students and those later in their careers. Features web links (through www.wiley.com/go/EST) to extensive material that is of a more tangential, specialized, or mathematical nature. Includes questions as footnotes to support the reader’s evolving comprehension of the material, with fully worked answers provided on the web. Provides web access to Excel® spreadsheets which allow the reader to model electrochemical events. Has a copious Appendix of relevant data.

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An empowering guide for students in STEMM that demystifies the process of securing undergraduate research experiences. Conducting research is an important foundation for many undergraduates on STEMM career paths. But landing an extremely competitive research spot that is also an enriching experience involves knowing how to present yourself effectively and an awareness of your goals and expectations. In this book, an expert lab manager and a longtime principal investigator share their secrets for obtaining these coveted positions. Offering advice to students in a wide variety of STEMM fields at both research-intensive universities and primarily undergraduate institutions, Getting In helps students navigate the hidden curriculum of academia, unofficial rules that disproportionately affect first-generation college students and those from low-income backgrounds and communities historically underrepresented in science. The authors provide not only an overview of STEMM research and lab opportunities but also specific strategies for the entire application process—including how to write emails that get noticed by busy professors, how to ask for a research position during office hours, and interview questions to prepare for—so students can claim their place in research settings. With its emphasis on the many interpersonal and professional benefits of research experiences, Getting In equips all STEMM undergrads with the tools they need both to secure these valued positions and to develop habits that will build productive relationships with their future research mentors.As an undergrad, Getting In will help you: determine how much time you can spend on research by evaluating your current activity level and goals. find the time to do research without giving up your social life or risking your GPA. avoid common mistakes in the search, application, or interview that make it harder to find a research experience. write emails that get you noticed by busy professors by customizing the included templates. prepare for tough interview questions so you’ll impress the interviewer with your answers, and be able to determine if the position is right for you. As a research mentor, Getting In will help your students: navigate the hidden curriculum of finding a research experience in science, technology, engineering, math, and medicine (STEMM). set realistic expectations for their research experience. understand why conducting research requires effort and will include some failure and other challenges. be active participants in their success in the lab.

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Marty Cohen was a gifted linguist and student of ancient military strategy who stepped away from academic Egyptology and opened a woodworking shop. Away from the bitter politics and petty rivalries, he’s happy to take care of his people, play the occasional war game, and try to make a good life. He discovers mysterious visions rob him of sleep, and then he gets summoned back to Egypt: an off-the-grid dig funded by an eccentric financier has discovered texts that may be the earliest Egypt has produced, and they’ll pay Marty silly amounts of cash just to fly out and take one little look. Marty turned his back on the academia game, but he’s a small business owner who has to make payroll during a recession, and he can’t say no to the money. But the texts open doors to more visions and to an astonishing journey: the ragtag team of archaeologists finds itself in protohistoric North Africa, a drying land dominated by monsters, where humanity is badly in need of champions. And behind the war against the monster overlords lies a greater struggle: Marty and his team have been chosen to be champions of all Earth and to run a gauntlet on humanity’s behalf. Failure will mean extinction. Praise for Time Trials: “This highly enjoyable novel by Rothman and Butler is full of nonstop action, bits of science, mystery, humor, and enough Ancient Egypt trivia to satisfy any history enthusiast. The quest narrative and the Dungeons & Dragons-style team structure recall familiar fantasy tropes, but the authors manage to develop the characters well, giving each of them their own distinct arcs and it results in a tale that’s well worth reading. The overarching mystery keeps the pages turning in an adventure tale that refreshingly shows respect for ancient civilizations and their accomplishments. An entertaining first entry in what promises to be a fantastic time-travel series.”—Kirkus Praise for D.J. Butler: "I have come to appreciate the work of D. J. Butler; He is a recent writer in a tradition of science fiction and fantasy I associate with Harry Turtledove, S. M. Stirling, Eric Flint, and Jerry Pournelle, with a sort of grittiness and focus on societal dynamics that I very much enjoy."—Warped Factor

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From the past decade vehicular ad hoc networks got tremendous attention from the industry, academia and research community. According to US National Highway Traffic Safety Administration (NHTSA), there are more than 30 thousands fatalities caused by the vehicle accidents in the U.S. each year, which worth around $250 billion economic cost annually. Research shows that 82% of these accidents can be reduced by the successful deployment of vehicular networks, because nearly 75% percent of vehicular crashes are caused by inattentive drivers. Literally, vehicular ad hoc networks means a network forms by the vehicles. But it has been evolved to network with the infrastructure as well due to the inherent intermittent nature of vehicle-to-vehicle (V2V) connection. The high mobility of vehicles, wireless communication loss and range constraints are the main reason for this intermittent V2V connection. So, now vehicular networks means communication between vehicle-to-vehicle (V2V) and vehicle-to-infrastructure (V2I). There are billions of dollars invested to research, deployment and testing of vehicular networks. For the emerging connected and autonomous vehicle (CAV), a stable vehicular networks is the foremost requirement. It is now very much visible that CAV will be the future of Intelligent Transportation System (ITS). The book is dedicated to discuss for the techniques, applications and relevant technologies of vehicular ad hoc networks and its challenges. The first chapter discuss about the routing protocols of vehicular networks. It focuses on different position-based routing protocols and their mechanisms for the successful use of vehicular networks for different applications. The second chapter discusses on the security and privacy issues on vehicular networks. A well-known security technique called Elliptic Curve Cryptography (ECC) is discussed to secure vehicular data from various tampering attacks. The third chapter discusses on the on-demand wireless broadcasting mechanism for improving data dissemination performance in terms of data delivery ratio and response time. A network-coding based approach has been investigated for improving the overall performance of existing classical data broadcast algorithms. The fourth chapter describes how to get a dependable system in the lossy communication medium. This chapter discusses on a number of fault diagnosis techniques, their strengths and weaknesses, and it reviews their implementations in mobile wireless networks. The fifth chapter discusses the basics of Blockchain technology, applications, research challenges and opportunities in the field. Finally, chapter six discuss about the identification and mitigation of the faulty nodes in the wireless network.

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NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists. This book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly 'Idea to Lead' then 'Lead to Drug Candidate', followed by 'Clinical Development', and finally 'Drug Manufacture'. The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies. Whilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R&D; for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes. About eMagRes Handbooks eMagRes (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this handbook and the complete content of eMagRes at your fingertips!Visit: www.wileyonlinelibrary.com/ref/eMagRes

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Electrochemistry is a discipline of wide scientific and technological interest. Scientifically, it explores the electrical properties of materials and especially the interfaces between different kinds of matter. Technologically, electrochemistry touches our lives in many ways that few fully appreciate; for example, materials as diverse as aluminum, nylon, and bleach are manufactured electrochemically, while the batteries that power all manner of appliances, vehicles, and devices are the products of electrochemical research. Other realms in which electrochemical science plays a crucial role include corrosion, the disinfection of water, neurophysiology, sensors, energy storage, semiconductors, the physics of thunderstorms, biomedical analysis, and so on. This book treats electrochemistry as a science in its own right, albeit resting firmly on foundations provided by chemistry, physics, and mathematics. Early chapters discuss the electrical and chemical properties of materials from which electrochemical cells are constructed. The behavior of such cells is addressed in later chapters, with emphasis on the electrodes and the reactions that occur on their surfaces. The role of transport to and from electrodes is a topic that commands attention, because it crucially determines cell efficiency. Final chapters deal with voltammetry, the methodology used to investigate electrode behavior. Interspersed among the more fundamental chapters are chapters devoted to applications of electrochemistry: electrosynthesis, power sources, “green electrochemistry”, and corrosion. Electrochemical Science and Technology is addressed to all who have a need to come to grips with the fundamentals of electrochemistry and to learn about some of its applications. It will constitute a text for a senior undergraduate or graduate course in electrochemistry. It also serves as a source of material of interest to scientists and technologists in various fields throughout academia, industry, and government – chemists, physicists, engineers, environmentalists, materials scientists, biologists, and those in related endeavors. This book: Provides a background to electrochemistry, as well as treating the topic itself. Is accessible to all with a foundation in physical science, not solely to chemists. Is addressed both to students and those later in their careers. Features web links (through www.wiley.com/go/EST) to extensive material that is of a more tangential, specialized, or mathematical nature. Includes questions as footnotes to support the reader’s evolving comprehension of the material, with fully worked answers provided on the web. Provides web access to Excel® spreadsheets which allow the reader to model electrochemical events. Has a copious Appendix of relevant data.

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Computational Drug Discovery A comprehensive resource that explains a wide array of computational technologies and methods driving innovation in drug discovery Computational Drug Discovery: Methods and Applications (2 volume set) covers a wide range of cutting-edge computational technologies and computational chemistry methods that are transforming drug discovery. The book delves into recent advances, particularly focusing on artificial intelligence (AI) and its application for protein structure prediction, AI-enabled virtual screening, and generative modeling for compound design. Additionally, it covers key technological advancements in computing such as quantum and cloud computing that are driving innovations in drug discovery. Furthermore, dedicated chapters that addresses the recent trends in the field of computer aided drug design, including ultra-large-scale virtual screening for hit identification, computational strategies for designing new therapeutic modalities like PROTACs and covalent inhibitors that target residues beyond cysteine are also presented. To offer the most up-to-date information on computational methods utilized in Computational Drug Discovery, it covers chapters highlighting the use of molecular dynamics and other related methods, application of QM and QM/MM methods in computational drug design, and techniques for navigating and visualizing the chemical space, as well as leveraging big data to drive drug discovery efforts. The book is thoughtfully organized into eight thematic sections, each focusing on a specific computational method or technology applied to drug discovery. Authored by renowned experts from academia, pharmaceutical industry, and major drug discovery software providers, it offers an overview of the latest advances in computational drug discovery. Key topics covered in the book include: Application of molecular dynamics simulations and related approaches in drug discovery The application of QM, hybrid approaches such as QM/MM, and fragment molecular orbital framework for understanding protein-ligand interactions Adoption of artificial intelligence in pre-clinical drug discovery, encompassing protein structure prediction, generative modeling for de novo design, and virtual screening. Techniques for navigating and visualizing the chemical space, along with harnessing big data to drive drug discovery efforts. Methods for performing ultra-large-scale virtual screening for hit identification. Computational strategies for designing new therapeutic models, including PROTACs and molecular glues. In silico ADMET approaches for predicting a variety of pharmacokinetic and physicochemical endpoints. The role of computing technologies like quantum computing and cloud computing in accelerating drug discovery This book will provide readers an overview of the latest advancements in Computational Drug Discovery and serve as a valuable resource for professionals engaged in drug discovery.

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This book offers a complete primer, covering the end-to-end process of forecast production, and bringing together a description of all the relevant aspects together in a single volume; with plenty of explanation of some of the more complex issues and examples of current, state-of-the-art practices. Operational Weather Forecasting covers the whole process of forecast production, from understanding the nature of the forecasting problem, gathering the observational data with which to initialise and verify forecasts, designing and building a model (or models) to advance those initial conditions forwards in time and then interpreting the model output and putting it into a form which is relevant to customers of weather forecasts. Included is the generation of forecasts on the monthly-to-seasonal timescales, often excluded in text-books despite this type of forecasting having been undertaken for several years. This is a rapidly developing field, with a lot of variations in practices between different forecasting centres. Thus the authors have tried to be as generic as possible when describing aspects of numerical model design and formulation. Despite the reliance on NWP, the human forecaster still has a big part to play in producing weather forecasts and this is described, along with the issue of forecast verification – how forecast centres measure their own performance and improve upon it. Advanced undergraduates and postgraduate students will use this book to understand how the theory comes together in the day-to-day applications of weather forecast production. In addition, professional weather forecasting practitioners, professional users of weather forecasts and trainers will all find this new member of the RMetS Advancing Weather and Climate series a valuable tool. Provides an end-to-end description of the weather forecasting process Clearly structured and pitched at an accessible level, the book discusses the practical choices that operational forecasting centres have to make in terms of what numerical models they use and when they are run. Takes a very practical approach, using real life case-studies to contextualize information Discusses the latest advances in the area, including ensemble methods, monthly to seasonal range prediction and use of ‘nowcasting’ tools such as radar and satellite imagery Full colour throughout Written by a highly respected team of authors with experience in both academia and practice. Part of the RMetS book series ‘Advancing Weather and Climate’

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Human blood performs many important functions including defence against disease and transport of biomolecules, but perhaps the most important is to carry oxygen – the fundamental biochemical fuel - and other blood gases around the cardiovascular system. Traditional therapies for the impairment of this function, or the rapid replacement of lost blood, have centred around blood transfusions. However scientists are developing chemicals (oxygen therapeutics, or “blood substitutes”) which have the same oxygen-carrying capability as blood and can be used as replacements for blood transfusion or to treat diseases where oxygen transport is impaired. Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood links the underlying biochemical principles of the field with chemical and biotechnological innovations and pre-clinical development. The first part of the book deals with the chemistry, biochemistry, physiology and toxicity of oxygen, including chapters on hemoglobin reactivity and regulation; the major cellular and physiological control mechanisms of blood flow and oxygen delivery; hemoglobin and myoglobin; nitric oxide and oxygen; and the role of reactive oxygen and nitrogen species in ischemia/reperfusion Injury. The book then discusses medical needs for oxygen supply, including acute traumatic hemorrhage and anemia; diagnosis and treatment of haemorrhages in "non-surgical" patients; management of perioperative bleeding; oxygenation in the preterm neonate; ischemia normobaric and hyperbaric oxygen therapy for ischemic stroke and other neurological conditions; and transfusion therapy in β thalassemia and sickle cell disease Finally “old”and new strategies for oxygen supply are described. These include the political, administrative and logistic issues surrounding transfusion; conscientious objection in patient blood management; causes and consequences of red cell incompatibility; biochemistry of red blood cell storage; proteomic investigations on stored red blood cells; red blood cells from stem cells; the universal red blood cell; allosteric effectors of hemoglobin; hemoglobin-based oxygen carriers; oxygen delivery by natural and artificial oxygen carriers; cross-linked and polymerized hemoglobins as potential blood substitutes; design of novel pegylated hemoglobins as oxygen carrying plasma expanders; hb octamers by introduction of surface cysteines; hemoglobin-vesicles as a cellular type hemoglobin-based oxygen carrier; animal models and oxidative biomarkers to evaluate pre-clinical safety of extracellular hemoglobins; and academia – industry collaboration in blood substitute development. Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood is an essential reference for clinicians, haematologists, medicinal chemists, biochemists, molecular biologists, biotechnologists and blood substitute researchers.

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'The authors set out to develop a framework that explains if and how co-creation can be used as ''strategy-as-practice.'' In doing so, they have produced a wonderful case study on co-creating a city's living and public space, the next movement and cultural turn following the ''creative class'' studies in urban design. There are innovative uses of narrative analysis to provide multiple perspectives of the co-creative process. It contains valuable insights for anyone interested in urban design.'- Hans Hansen, Texas Tech University'The book makes a very important contribution to the strategy-as-practice field as it proposes a thorough ethnography about how governments, academia, business, non-profits and citizens engage themselves in the strategic and collaborative process of planning. Drawing on a comprehensive and compelling notion of ''action nets'', the book provides a fascinating interpretive explanation that will be inspiring as well as for academics and practitioners. This timely volume raises a host of fascinating issues related to organizing and strategizing as ''co-creative practices'' and will be an invaluable resource across multiple domains and organizational research areas. Moreover, the book will convince you that ''small is beautiful''!'- Linda Rouleau, HEC Montreal, CanadaOver the past three decades, the European Capital of Culture has grown into one of the most ambitious cultural programs in the world. Through the promotion of cultural diversity across the continent, the program fosters mutual understanding and intercultural dialogue among citizens, thereby increasing their sense of belonging to a community. This insightful book outlines potential avenues through which culture and creativity can raise the imaginative capability of citizens and harness opportunities tied to what the book calls 'culture-driven growth'.Building on three years of observations, interviews and research the authors argue that a 'strategy-as-practice' perspective can reveal how strategy making is enabled or constrained by organizational and social practices. The authors reveal how the 'sweet-spot' of city regeneration occurs where urban and cultural planning are aligned. They then evaluate the practice of 'co-creation' within organizing bodies and investigate the extent to which its success depends on a fusion of top-down rules and bottom-up action. Urban Strategies for Culture-Driven Growth will appeal to international scholars and students in organization studies, geography, city governance and planning, urban design, and urban and regional development. Policymakers and planners will also find it to be a valuable resource.

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This book offers a complete primer, covering the end-to-end process of forecast production, and bringing together a description of all the relevant aspects together in a single volume; with plenty of explanation of some of the more complex issues and examples of current, state-of-the-art practices. Operational Weather Forecasting covers the whole process of forecast production, from understanding the nature of the forecasting problem, gathering the observational data with which to initialise and verify forecasts, designing and building a model (or models) to advance those initial conditions forwards in time and then interpreting the model output and putting it into a form which is relevant to customers of weather forecasts. Included is the generation of forecasts on the monthly-to-seasonal timescales, often excluded in text-books despite this type of forecasting having been undertaken for several years. This is a rapidly developing field, with a lot of variations in practices between different forecasting centres. Thus the authors have tried to be as generic as possible when describing aspects of numerical model design and formulation. Despite the reliance on NWP, the human forecaster still has a big part to play in producing weather forecasts and this is described, along with the issue of forecast verification – how forecast centres measure their own performance and improve upon it. Advanced undergraduates and postgraduate students will use this book to understand how the theory comes together in the day-to-day applications of weather forecast production. In addition, professional weather forecasting practitioners, professional users of weather forecasts and trainers will all find this new member of the RMetS Advancing Weather and Climate series a valuable tool. Provides an end-to-end description of the weather forecasting process Clearly structured and pitched at an accessible level, the book discusses the practical choices that operational forecasting centres have to make in terms of what numerical models they use and when they are run. Takes a very practical approach, using real life case-studies to contextualize information Discusses the latest advances in the area, including ensemble methods, monthly to seasonal range prediction and use of ‘nowcasting’ tools such as radar and satellite imagery Full colour throughout Written by a highly respected team of authors with experience in both academia and practice. Part of the RMetS book series ‘Advancing Weather and Climate’

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