Search results for ""taylor francis inc""

This book provides an in-depth discussion of various aspects of metal ecotoxicology. State-of-the-art information and techniques in areas ranging from metal behavior in surface waters to bioaccumulation kinetics and toxicokinetics to community effects are presented in a hierarchical arrangement. Specific topics discussed include metals in abiotic components of ecosystems, autecology (effects of metals relative to the individual or a single species), and metals in marine and freshwater systems in the context of synecology (species associated and interacting as a unit). This is an important book that will be useful to researchers, risk assessment consultants, regulatory personnel, and teachers and students.

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This easy-to-read, concise book is filled with examples, hints, reminders and reviews designed to help engineers and scientists develop effective writing skills. Use the book to learn to write better reports, memos, and journal articles and keep it close at hand when you have questions about organization, clarity and style, writing and revising rough drafts, graphics, workplace writing, computers in writing, and legal issues in writing. The book also contains four helpful appendices on common errors, equations and abbreviations, preparing manuscripts for publication, and documenting information sources. Effective Writing Strategies for Engineers and Scientists provides easy training for the type of writing required of engineers and scientists, gives specific advise for conveying complicated information, and describes how to synthesize information according to specific writing strategies. It is a "must" for every scientist's and engineer's bookshelf.

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This newly published book is an organized collection of papers dealing with changes in the quality of water as it moves through the world's hydrologic cycle-from the sea, lakes, and rivers-to its hydrosphere and then back to earth as precipitation, where the water again percolates through the soil or falls on the ocean, rivers, or lakes. (Changes that occur are physical, chemical, and biological.) Though chapters discuss results of specific lab or field experiments which in themselves have value for the scientist, focus is on processes involved. Many general concepts of water quality are provided in this cohesively organized book.

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Lukang is a sleepy provincial town on the east coast of Taiwan. The Lukang "rebellion" was a series of well-organised mass demonstrations in 1986 and 1987 to block construction by the DuPont Corporation of a titanium dioxide plant nearby. If this protest had occurred just a few years earlier, no doubt it would have been crushed by a powerful government determined to promote development at any cost. If it had been a few years later, it probably would have passed unnoticed. But it came at a time just when environmental consciousness in Taiwan had reached a critical mass and as the government was introducing political reforms allowing unprecendented scope to new forms of civil action. In this atmosphere, a handful of determined, capable activists, bent on keeping a giant multinational corporation out of their "old home", focused the attention of the entire island on Lukang, raised the national consciousness about threats to the natural environment, and challenged the rules that government officials and industrial leaders in Taiwan had come to take for granted. The Lukang rebellion was one of those small events with large consequences that make for interesting and significant history.

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This series of essays on insurgency and revolution focuses on events in Latin America since 1956. The contributors discuss revolutionary theory, the nature of social movements and models of social action. Topics raised include terror, guerilla regimes, mobilizing peasants, and the vulnerability of regimes to revolution.

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Increase your awareness of the relative addiction liabilities of various drugs and drug classes that are commonly abused. A timely and masterful new book, Addiction Potential of Abused Drugs and Drug Classes clarifies, in contemporary terminology, the state of addiction liability of cocaine, opiates, alcohol, sedative-hypnotics, nicotine, anxiolytics, marijuana, inhalants and anesthetics, and PCP and hallucinogens--the nine drugs that are most abused today. Authorities combine their research expertise with the available scientific literature to evaluate those factors which contribute to the addictive qualities of drugs. Specific chapters highlight the positive and negative reinforcement qualities that make drugs rewarding, focus on the two major subtypes of alcoholics, and cover the neuroanatomical and neurochemical bases of psychological dependence, the greatest contributing factor to drug addiction. An essential new resource for scientists, clinicians, and administrators, Addiction Potential of Abused Drugs and Drug Classes also highlights those areas where more work is needed in order to understand how individual drugs affect the processes of dependence, tolerance, and addiction, so that adequate treatment of these disorders can be discovered.The book was written for teachers and researchers in the chemical dependency field, to provide an up-to-date review of the literature. In addition, physicians, nurses, and pharmacists will find the book to be valuable as an update on the relative addiction strengths of abused drugs. Finally, treatment counselors and professionals with some knowledge of physiology and pharmacology will be interested in the book because of its relevance to the clinical treatment of chemically-dependent patients.

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Professionals who are on the cutting edge of educational computing discuss, in this provocative new book, one of the most exciting prospects of the field--harnessing the power of the computer to enhance the development of problem-solving abilities. Here is everything that educators will need to know to use computers to improve higher level skills such as problem solving and critical thinking. Current aspects of problem-solving theory, a philosophical case for including programming languages in the curriculum, state-of-the-art research on computers and problem solving, and a look at problem-solving software are included in this comprehensive volume. The research and its application to instruction are grounded in problem-solving theory--making this book a unique and critical addition to the existing literature.

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Here is a powerful look at gender issues in the criminal justice system, particularly as gender is related to sex offenses and the system’s response to those offenses. Experts examine inmate sexual aggression, gender disparity in bail setting, racial patterns of rape, the female offender’s adjustment to prison life, the psychological profile of female first offenders, and the self-image of juvenile prostitutes.

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A wide range of special librarians from banking, finance, and government provide descriptive accounts of their respective collections in this comprehensive volume. They provide an introduction to some of the major library and archival resources available to bankers, financiers, and investors, as well as offer access to the historian and scholar doing research in some aspect of business. The collections represented include the Federal Reserve System, the Joint Bank-Fund Library of the International Monetary Fund and the World Bank, Standard & Poor’s, the Wells Fargo Corporation, the Lippincott Library of the Wharton School, and more.

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As the third leading cause of death in the United States, stroke accounts for one in every fifteen deaths and is the major cause of disability in the country. Compiled by a renowned editorial team, this reference bridges the gap between basic science and patient care protocols, and collects 43 expertly written chapters that range from laboratory-based research on animal models to the progression, mechanisms, treatment, and prognosis of diseases such as subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), focal ischemic stroke, and global cerebral ischemia.

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Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwelling Neural Implants: Strategies for Contending with the In Vivo Environment examines many of these challenges, paying particular attention to how the healing of tissues surrounding an implant can impact the intended use of a device. The contributions are divided into four sections · Part one examines wound healing from the initial insertion trauma through the inflammatory and repair process, explaining how the action of healing varies throughout different areas of the body. · Part two considers various performance issues specific to particular implant components, including those that arise from the chemical, mechanical, thermal, and electrical impact on surrounding tissues. It discusses challenges that result from chronic tissue stimulation and heat effects that occur with on-chip and telemetric processing. · Part three presents both in vitro and in vivo approaches to assessing wound healing response to materials. It includes the contribution of the developer of a chronic hollow fiber membrane implant who explains how an in vivo model is used to assess molecular transport in brain tissue surrounding the implant. · The final section evaluates molecular and materials strategies for intervening in CNS wound repair and enhancing the electrical communication between the electrode surface and the surrounding tissue. It also presents novel approaches to nerve regeneration and repair.

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Exploring a wide spectrum of oncologic imaging technologies with current and future applications ranging from ultrasound and PET to MRI, this reference analyzes recent developments concerning every available imaging technique-furnishing the most up-to-date research on technological advances in cancer imaging and their potential impact on patient care and treatment.

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Thoroughly examining tuberculosis from historical, theoretical, and clinical perspectives, this Third Edition merges state-of-the-art research developments with principles of programmatic TB management. Each of the 50 chapters analyze current studies on TB mechanisms and treatment and will meet the needs of all who work in the field of TB control, whether in low-income, high-prevalence areas or in low-prevalence industrialized countries.

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"The prominence of the Bupleurum species cannot be overstated. Across China and Japan, it serves as a main or supplementary ingredient in over two thirds of traditional medications. For over 2000 years, it has been used to treat fevers, intestinal maladies, malaria, and countless other afflictions. Modern research indicates that it may possess anti-tumor qualities, and researchers continue to report its impact on a wide range of ailments, from hepatitis and epilepsy, to irregularity and menopause, as well as psychosis and schizophrenia.Bupleurum Species: Scientific Evaluation and Clinical Applications brings together the work of leading researchers from Asia and Europe who examine this remarkable genus of plants. Providing a comprehensive look at all aspects relevant to the species, this historic volume- q

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Responding to the growing recognition of Obstructive Sleep Apnea (OSA) as a major medical condition and the emergence of exciting new therapies, this source analyzes the clinical features, characteristics, comorbidities, and impact of OSA on patient biological systems and quality-of-life. Edited by the Director of the Center for Human Sleep Research at Stanford, this source supplies an all-encompassing guide to the comorbid medical conditions and socioeconomic impact of OSA.

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Divided into five parts, Microbial Food Contamination, Second Edition looks at emerging foodborne human pathogens andcomprehensively evaluates the microbiology, biochemistry, detection, risk, and threat of foodborne illness in today’s global market. The first section introduces new insights into the pathogenic effect of E. coli, viral diseases, and protozoan parasites, as well as prions and other zoonotic diseases. It discusses mycotoxins and aflatoxins, particularly the carcinogenicity of aflatoxin B1 and the chemoprevention of liver cancer.Detection, Monitoring, and Control Presenting recent advances in the detection and monitoring of foodborne pathogens, section two reviews rapid electrochemical biosensors, new methods to detect prion diseases, and the use of polymerized chain reaction (PCR) for detection, identification, and typing of microorganisms. Section three examines control and prevention measures including Kosher and Halal food laws, and the use of naturally occurring antimicrobials, irradiation, and other physical control strategies. It also considers the genetic and biochemical control of aflatoxigenic fungi. International Regulation and Trade Globalization reduces traditional geographic borders that once prohibited pathogens from spreading and increases the risk of transnational outbreaks. The impact of this trend on international trade is evaluated in section four with a look at the implications of mad cow disease on the beef trade. It also provides an overview of programs to mitigate contamination such as the Codex Alimentarius and the International Food Safety Authorities Network. Bioterrorism Addressing the most frightening aspect of microbial contamination, section five explores bioterrorism and the different chemical, radiological, and biological agents that could be employed to deliberately contaminate food. Contributors take a critical look at present food protection strategie

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Because of developments in powerful computer technology, computational techniques, advances in a wide spectrum of diverse technologies, and other advances coupled with cross disciplinary pursuits between technology and its greatly significant applied implications in human body processes, the field of biomechanics is evolving as a broadly significant area. This Third Volume presents the advances in widely diverse areas with significant implications for human betterment that occur continuously at a high rate. These include dynamics of musculo-skeletal systems; mechanics of hard and soft tissues; mechanics of muscle; mechanics of bone remodeling; mechanics of implant-tissue interfaces; cardiovascular and respiratory biomechanics; mechanics of blood flow, air flow, flow-prosthesis interfaces; mechanics of impact; dynamics of man machine interaction; and numerous other areas. The great breadth and depth of the field of biomechanics on the international scene requires at least four volumes for adequate treatment. These four volumes constitute a well integrated set that can be utilized as individual volumes. They provide a substantively significant and rather comprehensive, in-depth treatment of biomechanic systems and techniques that is most surely unique on the international scene.

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Lung cancer is the leading cause of cancer death in the United States, but IGRT (image guided radiation therapy) offers the possibility of more aggressive and enhanced treatments. The only available source on the subject that emphasizes new imaging techniques, and provides step-by-step treatment guidelines for lung cancer, this source helps clinicians locate and target tumors with enhanced speed, improve the accuracy of radiation delivery, and correctly target cancerous masses while avoiding surrounding structures.Edited by radiation oncology experts from the renowned M.D. Anderson Cancer Center, this guide: focuses on novel approaches using IGRT, particularly PET/CT, SPECT, 4-D CT, stereotactic body radiation therapy, IMRT and proton radiotherapy, and offers expert guidance on the dose, fractionation, target volume delineation (including recommended margins with and without respiratory gating based on our new 4-D CT study), and normal tissue tolerances stands as the first step-by-step guide for radiation oncologists to implement new image-guided techniques into their day-to-day clinical practice, and considers the practical issues of implementing these approaches into their routine helps clinicians use imaging technologies to detect changes in tumor size, shape, position, or metabolism over a course of radiotherapy treatment provides disease stage-specific treatment guidelines and clearly lays out imaging techniques serves as roadmap for future research and development

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Both strength training and weight training are recognized by the American College of Sports Medicine as vital to a high quality of life. They are also of tremendous benefit to young, healthy adults and adults with or at risk for osteoporosis. Most information on nutrition and strength athletes, however, is scattered throughout pamphlet-type publications and magazines and tends to be written by individuals with little or no professional training in the field of nutrition. Nutrition and the Strength Athlete is an authoritative, scientifically based text that addresses virtually every aspect of nutrition as it pertains to the strength athlete. The book begins with an extensive review of the parameters defining resistance training. Subsequent chapters cover areas of interest to those who participate in resistance training, such as energy-yielding nutrients, vitamins and minerals, dietary supplements, hormones, hydration, and nutritional considerations to support the immune system . The book concludes with nutritional concerns for women who resistance train and strength athletes who play tennis. This definitive work discusses the following:An overview of studies done on weight training Anabolic / androgenic steroid use Traditional nutritional and energy requirements and the most recent findings on supplementation - including vitamin, amino acid, and phosphagen supplements Various classes of strength-trained athletes and the regimens of strength trainingEach chapter is written by an experienced and highly regarded researcher and/or practitioner in the respective area. In fact, all of the authors participate in strength training as part of their lifestyle, making this book unique in its approach to Nutrition and the Strength Athlete.

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Bridging the gap between human-computer engineering and control engineering, Human Behavior Learning and Transfer delineates how to abstract human action and reaction skills into computational models. The authors include methods for modeling a variety of human action and reaction behaviors and explore processes for evaluating, optimizing, and transferring human skills. They also cover modeling continuous and discontinuous human control strategy and discuss simulation studies and practical real-life situations.The book examines how to model two main aspects of human behavior: reaction skills and action skills. It begins with a discussion of the various topics involved in human reaction skills modeling. The authors apply machine learning techniques and statistical analysis to abstracting models of human reaction control strategy. They contend that such models can be learned sufficiently to emulate complex human control behaviors in the feedback loop. The second half of the book explores issues related to human action skills modeling. The methods presented are based on techniques for reducing the dimensionality of data sets, while preserving as much useful information as possible. The modeling approaches developed are applied in real-life applications including navigation of smart wheel chairs and intelligent surveillance.Written in a consistent, easily approachable style, the book includes in-depth discussions of a broad range of topics. It provides the tools required to formalize human behaviors into algorithmic, machine-coded strategies.

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The assessment of bioequivalence is an important process whereby the bioavailability of a generic drug product is compared with its brand-name counterpart. Generic pharmaceutical products must be approved as therapeutic equivalents to the brand name alternative in order to be interchangeable. The demonstration of bioequivalence is an important component of therapeutic equivalence. Bioequivalence studies are very expensive, time consuming and always have the possibility of failure. The objective of this textbook is to describe some of those specific bioequivalence issues which need to be considered for the design and conduct of bioequivalence studies. By exploring scientific, legal, and international regulatory challenges, Generic Drug Development, discusses the use of alternative approaches to the measurement of plasma drug concentrations for the demonstration of bioequivalence, and covers bioequivalence procedures for drug products that are not easily assessed - based upon the physical and chemical properties of the active drug and the nature of the drug product.

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Metabolism of Brain Peptides discusses neuropeptide metabolism in light of recent research. It describes the processing mechanisms in the production of biologically active peptides. It details distribution of the variety of neuropeptides in the brain and comprehensively reviews the effects of these neuropeptides on behavioral and physiological functions. The book also examines termination mechanisms for the biological activities of neuropeptides in light of recent knowledge of their distribution, their receptors and their possible inactivation enzymes in various functional regions of the brain and at the blood-brain barrier.

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The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin absorption and the various governmental and industrial programs concerned with skin permeation and toxicity. These include alternative in silico, in vitro, and in vivo strategies to conduct studies for regulatory requirements. To make room for this new expanded content, the editors are publishing a concurrent text entitled: Dermatological and Cosmetic Development with a concentration on subjects concerned with dermatological and cosmetic therapies

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An integral part of any communications system, high-frequency and microwave design stimulates major progress in the wireless world and continues to serve as a foundation for the commercial wireless products we use every day. The exceptional pace of advancement in developing these systems stipulates that engineers be well versed in multiple areas of electronics engineering. With more illustrations, examples, and worked problems, High-Frequency and Microwave Circuit Design, Second Edition provides engineers with a diverse body of knowledge they can use to meet the needs of this rapidly progressing field.The book details the modulation and demodulation of circuits and relates resonant circuits to practical needs. The author provides a logical progression of material that moves from medium frequencies to microwave frequencies. He introduces rectangular waveguides as high-pass devices and explains conditions under which dielectric breakdown may limit the amount of power that may be transmitted in a completely expanded chapter. The section on antennas is completely updated to demystify the useful characteristic of antennas and relate their performance to the requirements of digital communication systems. Exploring the latest developments in communications engineering, this reference outlines a variety of topics using sufficient mathematical derivations and provides an overview of the concepts engineers need to understand current technologies and develop those of the future.

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Covering the entire array of photodermatological topics necessary to stand at the head of thisburgeoning discipline, this source contains expertly written chapters that offer recommendationsand guidelines from opinion-forming international authorities. Reviewing the entire range ofphotodermatoses, as well as the management, treatment, identification, and assessment of theseconditions, this source includes discussions of narrow and broadband UVB, PUVA, photopheresis, UVA1 therapy, and photodynamic therapy, the principles and medical and cosmetic uses of lasers and similar sources, and appendices on phototesting, photopatch testing, and the development of phototherapy units to stand at the forefront of this burgeoning dermatological subject.

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Reverse engineering is widely practiced in the rubber industry. Companies routinely analyze competitors’ products to gather information about specifications or compositions. In a competitive market, introducing new products with better features and at a faster pace is critical for any manufacturer. Reverse Engineering of Rubber Products: Concepts, Tools, and Techniques explains the principles and science behind rubber formulation development by reverse engineering methods. The book describes the tools and analytical techniques used to discover which materials and processes were used to produce a particular vulcanized rubber compound from a combination of raw rubber, chemicals, and pigments.A Compendium of Chemical, Analytical, and Physical Test MethodsOrganized into five chapters, the book first reviews the construction of compounding ingredients and formulations, from elastomers, fillers, and protective agents to vulcanizing chemicals and processing aids. It then discusses chemical and analytical methods, including infrared spectroscopy, thermal analysis, chromatography, and microscopy. It also examines physical test methods for visco-elastic behavior, heat aging, hardness, and other features. A chapter presents important reverse engineering concepts. In addition, the book includes a wide variety of case studies of formula reconstruction, covering large products such as tires and belts as well as smaller products like seals and hoses.Get Practical Insights on Reverse Engineering from the Book’s Case StudiesCombining scientific principles and practical advice, this book brings together helpful insights on reverse engineering in the rubber industry. It is an invaluable reference for scientists, engineers, and researchers who want to produce comparative benchmark information, discover formulations used throughout the industry, improve product performance, and shorten the product development cycle.

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The ability of molecular and cellular imaging to track the survival, migration, and differentiation of cells in vivo as well as monitor particular gene expression in living subjects is rapidly moving from the research laboratory into daily clinical settings. The interdisciplinary nature of the field mandates a constant dialogue among molecular and cellular biology, chemistry, physics, image analysis, and drug discovery to develop and translate promising approaches into reliable scientific applications and viable clinical diagnostic tools.Bringing together a select panel of internationally recognized authors, Molecular and Cellular MR Imaging provides a state-of-the-science overview of the multidisciplinary nature of the field and illustrates the application of these various sciences to investigate specific biological processes in animals and humans. Using a systematic organization to present diverse information, the text begins with an introductory chapter that defines cellular and molecular imaging and explains why magnetic resonance imaging (MRI) is the most versatile approach for noninvasive, in vivo studies. The first section examines the physicochemical principles of various contrast agents including paramagnetic, superparamagnetic, CEST, and PARACEST agents, as well as smart and sensing agents. The second section summarizes the wide variety of applications for molecular imaging of genes and of disease states. Contributions cover cancer, apoptosis, cardiovascular and neurodegenerative disease, and the use of pharmacological MRI. The third section is devoted to cellular imaging under a variety of applications, and the final section discusses the translational aspects and future directions of cellular and molecular MR imaging. Molecular and Cellular MR Imaging highlights the diversity of skills required to translate advancements in various fields of research into practical applications that promise to revolutionize in vivo imaging as a diagnostic

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Studying large sets of genes and their collective function requires tools that can easily handle huge amounts of information. Recent research indicates that engineering approaches for prediction, signal processing, and control are well suited for studying multivariate interactions. A tutorial guide to the current engineering research in genomics, Introduction to Genomic Signal Processing with Control provides a state-of-the-art account of the use of control theory to obtain intervention strategies for gene regulatory networks. The book builds up the necessary molecular biology background with a basic review of organic chemistry and an introduction of DNA, RNA, and proteins, followed by a description of the processes of transcription and translation and the genetic code that is used to carry out the latter. It discusses control of gene expression, introduces genetic engineering tools such as microarrays and PCR, and covers cell cycle control and tissue renewal in multi-cellular organisms.The authors then delineate how the engineering approaches of classification and clustering are appropriate for carrying out gene-based disease classification. This leads naturally to expression prediction, which in turn leads to genetic regulatory networks. The book concludes with a discussion of control approaches that can be used to alter the behavior of such networks in the hope that this alteration will move the network from a diseased state to a disease-free state.Written by recognized leaders in this emerging field, the book provides the exact amount of molecular biology required to understand the engineering applications. It is a self-contained resource that spans the diverse disciplines of molecular biology and electrical engineering.

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Alkali Cation Transport Systems in Prokaryotes is the first book that brings together the physiological, structural, and molecular biological aspects of the transport of sodium, potassium, and ammonium across the bacterial cell membrane. Sodium translocation plays a major role in energy coupling of some prokaryotes, and much of the book is devoted to new and exciting developments in this field. Over 30 experts have contributed to this excellent reference for microbiologists, biochemists, molecular biologists, cell biologists, chemotherapists, and researchers interested in bioenergetics.

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This fascinating work is divided into two main sections. Part I reviews the basic principles of water movement in channels and the mass balance approach common to most models. It also covers the practical usefulness, model peer review, and guidance on model selection and calibration. Part II discusses flow simulation and prediction of time of travel, dye tracing and mixing, heat balance and temperature modeling, and reaeration and volatilization. This interesting, easy-to-read volume includes comprehensive reviews for the use of fluorescent water tracing dyes, longitudinal dispersion, evaporation and wind speed functions, prediction of saturation concentrations of dissolved oxygen, and reaeration coefficients. This book furnishes the reader with appendices which provide a synopsis of available computer models and gives a comprehensive listing of methods used to measure flow rates in rivers, tributaries, and pipes and channels introducing wastewaters into streams. This volume is a valuable, indispensable reference for all researchers, instructors, students in advanced environmental modeling courses, and practicing engineers.

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Soil Solarization describes the principles and technology of soil solarization and the use of soil solarization for different crops and cropping systems. The book evaluates and interprets the extensive amount of literature available on soil solarization in relation to climatic effects and changes in populations of soil-borne microorganisms and weeds. It also compares the advantages and disadvantages of soil solarization with other methods of soil disinfestation, such as soil steaming and fumigation. Soil Solarization explores the effects of soil solarization, covering such points as biological control, changes in soil chemistry involving mineral elements, as well as other changes, such as soil salinity and soil structure. It is suitable for solarizers, researchers working with soil-borne pathogens and soil microbiology, plant protection experts, and other plant researchers and extension specialists.

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Biochemistry and Physiology of Polyamines in Plants provides a comprehensive introduction to commonly used methods in polyamine research and the problems unique to plant studies. Topics discussed include polyamine metabolism in plants, the functions of polyamines in plant growth and development, and an examination of analytical methods for polyamines and enzymes of polyamine metabolism. Agronomists, plant physiologists, and biochemists interested in polyamines in plants will find this book to be a valuable reference resource.

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A comprehensive review of intraoperative radiation therapy, beginning with the rationale for innovative treatment and the radiobiology of single doses. Problems encountered in modifying a linear accelerator and a radiation therapy suite are reviewed in detail along with special problems relating to technology, nursing, anesthesiology, and various surgical subspecialties. Intraoperative radiation therapy applicators and dosimetric considerations are also reviewed. This text is a valuable reference tool for institutions planning to develop or construct intraoperative radiation therapy facilities.

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Critical Analysis of Monoclonal Antibody Therapy in Transplantation provides a critical analysis of monoclonal antibody therapies in transplantation. The book presents diverse approaches to monoclonal antibody therapy in transplantation and addresses some of the serious obstacles that remain both in understanding these mechanisms and in successfully applying them in clinical situations. The background and rationale for OKT3 therapy are examined and an extensive clinical experience with OKT3 induction therapy in cardiac transplantation is reviewed. The book also examines the background and rationale for the use of anti-TcR (??), anti-IL-2R, and anti-LFA-1 monoclonal antibodies in clinical transplantations. Other topics include the use of monclonal antibodies to CD4 and CD8 for the induction of adult transplantation tolerance in rodents and the possibilities for applying anti-idiotypical strategies that have proven useful in autoimmunity models to transplant recipients. Researchers and basic scientists involved in this field will find the book a fascinating and useful resource for their investigations.

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This book presents a wide variety of immuno-gold techniques for use in virus diagnosis and research. Protocols are presented for state-of-the-art techniques, including in situ hybridization, freeze substitution, and the utilization of ultra-small probes and replicas for use by virologists and electron microscopists identifying and studying viruses, their components, and replication in cells. The procedures are described by eminent scientists and are pertinent to both experienced researchers and newcomers to this field who are interested in the localization of low antigenic mass structures.

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The Cytoskeleton of the Algae provides a comprehensive examination of the structural features of the cytoskeleton in phylogenetic branches of algae. The book also analyzes the possible functions of cytoskeletal components using structural, physiological, genetic, and molecular approaches. Many taxa are described in detail, mirroring the dramatic progress that has been made in recent years in this new research field. Many unique structural elements and motility phenomena are described for the first time, and other features common to all plant cells, such as cell polarity, cytoplasmic streaming, mitosis, cell wall deposition, and contractile events are analyzed using algae as experimental model systems. The Cytoskeleton of the Algae reflects the enormous impact that research on the algal cytoskeleton has on both phycology and plant cell biology, and it will serve as an excellent reference volume for researchers in this area.

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This text looks at mineral fibers, their occurrence, production, properties and their uses. The part of this book covering pathogensis and modes of action begins with a chapter on the physicochemical properties of asbestos fibers and a chapter on the deposition and retention of fibers within the lung and their clearance.

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This comprehensive book is a compilation of Professor Lubomir S. Hnilica's twenty years of research experimentally addressing the chemistry and the biological functions of chromosomal proteins. The histones and other nuclear proteins found associated with DNA in a number of tissues and cell types are featured. Lubomir Hnilica played a major role in establishing the extent to which these basic chromosomal polypeptides are conserved and the manner in which they interact with DNA to modify chromatin structure. In addition, non-histone chromosomal protein research is explained, and his technique of applying several biochemical and immunological approaches to the characterization of this complex and heterogeneous class of chromosomal polypeptides is discussed. Highlighted is the use of chemical crosslinking for studying protein/DNA interactions in intact cells. The proteins as well as the structure, organization, and regulation of the genes are also presented.

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This comprehensively written text covers, in-depth, all aspects of bioadhesive systems. Bioadhesive systems are presently playing a major role in the field because of their ability to maintain a dosage form at a precise body-site for a prolonged period of time over which the active principle is progressively released. Included in this book are descriptions of the different mucosae in healthy and pathological situations, a theoretical approach of polymers-mucin interactions, and a comparative description of the methods used to evaluate bioadhesion. Up-to-date reviews of pharmaceutical applications are also given - subdivided according to the route of administration and type of system. It also contains a chapter devoted to the fundamentals of bioadhesion. This reference is an indispensable guide for researchers in the pharmaceutical field as well as academic researchers.

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Attitudes toward long-term care contain a strong residue of negativity in today’s society and current problems with the system augment such perceptions. Unless dealt with now, this will only get worse, as the 85-and-older crowd is the fastest growing part of the population, and the first wave of Baby Boomers is approaching 60. Exploring and delineating the issues from every angle, the Handbook of Long-Term Care Administration and Policy addresses key areas such as history, trends, and outlook for this growing concern.The first part of the handbook provides the context for the rest of the volume. The heart of the text, it covers topics such as public perception, understanding system failure, and the tensions between the social model and the medical model. Part two focuses on recipients and their care givers while part three emphasizes services, exploring models that confront the barriers to achieving coordination of care. Part four addresses issues related to the administration of care such as the context in which governing bodies have evolved, ethical concerns, and the importance and benefits of transparency of information. The book concludes with an examination of policymaking and funding, the challenges inherent in getting long term care on the public agenda, geriatric mental health needs, and future issues that will fuel a national debate. A stand-alone text introducing long-term care administration and policy, this book provides a foundation for understanding the fragmented service delivery system and a guide through the maze of long-term health care.

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Innovative Leukemia and Lymphoma Therapy provides a complete and up-to-date overview of the exciting new treatment modalities in leukemia and lymphoma that are being introduced in the clinic today. Written by international experts in the field, this volume examines clinical studies on topics such as: tyrosine kinase inhibitors, histon deacetylase inhibitors, and farnesyl transferase inhibitors radioimmunotherapy, gene-directed therapy, and immunotherapy by vaccination monoclonal antibodies anti-angiogenesis approaches Within each chapter, this well-illustrated, comprehensive source provides a summary of the rationale for treatment, the pathways that are involved, and the translational research to students, scientists, and clinicians. In addition, this book focuses on the concerns of conventional but novel anticancer agents, modulation of classical multidrug resistance, and modulators of single agent drug resistance.

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Hydroxyoximes and Copper Hydrometallurgy provides a current examination of what is known regarding hydroxyoxime extractants, the chemistry and physicochemistry of extraction, and the potential of applying hydroxyoximes for extraction of copper and other metals in industrial processes. Topics addressed include the development of the hydrometallurgical process, methods of synthesis and structural characteristics, extraction properties, losses of active substances and problems associated with environmental pollution, the potential of metal extraction and separation with hydroxyoximes, methods of extraction and stripping that can improve metal separation and recovery, the applications of hydroxyoximes in various membrane processes, and industrial processes and equipment used for processing oxide ores and tailing. The book will benefit metallurgists, hydrometallurgists, analytical and physical chemists, and researchers in mining industries and solvent extraction.

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This book emphasizes the occurrence of sublethal injury in the indicator and pathogenic bacteria commonly encountered in foods, water and feed and modifications of the currently recommended methods for the effective detection of these bacteria. Chapters include methods for recovering injured "classical" enteric pathogenic bacteria from foods and for recovering injured pathogenic organisms from animal food. Detection and significance of injured indicator and pathogenic bacteria in water are explained, as well as detection of injured sporeforming bacteria from foods. This volume is extremely useful for individuals in the academic institutions, industries, federal and state regulatory agencies, public health service and hospitals who are interested in effective detection of indicator and pathogenic bacteria in food and water.

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The purpose of this monograph is to provide a summary for those who are active in the field of phthalocyanine research. This volume allows the reader to quickly-and at a reasonable cost-determine what is being accomplished so that he may plan his own research programs. It covers such topics as synthesis, reactions, inks, energy systems, coatings, toners, and electrophotographic plates and developers, just to name a few. Packed with over 40 structural drawings of phthalocyanine molecules, this one-of-a-kind reference provides the necessary description and visualization to stimulate further research. This work is an indispensable resource for researchers and practitioners, both novice and experienced, in the field of phthalocyanine science and technology.

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This book covers pathophysiology of fever, the general approach to the febrile patient, and offers a systematic, in-depth discussion regarding the differential diagnosis of unexplained fever. The authors define an unexplained fever as a fever which lasts a minimum of 14 days and whose etiology is not known. This one-of-a-kind publication highlights the main causes of fever, specifically infectious diseases, cancer, connective tissue diseases, various rare disorders, plus etiologies which are often ignored. Also, laboratory and medical imaging techniques for diagnosing fevers are included. Written in a comprehensive, unrepetitious style, this "must-have" resource includes such aspects as the history of the fever, a review of published cases, the approach to the patient, and an analytical review. This up-to-date volume is an indispensable guide that should be read by physicians, surgeons, internists, microbiologists and other medical professionals.

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Recent research has emphasized that socially transmitted information may affect both the gene pool and the phenotypes of individuals and populations, and that an improved understanding of evolutionary issues is beneficial to those working towards the improvement of human health. Equally, an improved awareness of how human behavior influences health and reproductive fitness is starting to shed new light on the processes that shape the evolution of human behavior and the human mind.Focusing directly on these emerging trends, Social Information Transmission and Human Biology bridges the gap between primarily theoretical work undertaken by those with evolutionary interests and biomedical work undertaken by those dealing with practical issues in human health and demographics. Incorporating papers from a symposium organized under the auspices of the UK Society for the Study of Human Biology, this volume merges the perspectives of internationally renowned evolutionary and theoretical biologists, zoologists, anthropologists, archaeologists, psychologists, and medical researchers whose work is linked by common themes addressing how information is transmitted socially and how its transmission influences both immediate and evolutionary biological outcomes. Emphasizes the diverse ways in which socially transmitted information impacts on human biologyTo illustrate these themes, the chapters draw on models and data ranging from observations on chimpanzee populations in the wild and on the human archaeological record, to studies of contemporary humans in both developing and industrialized countries. Taking a broad approach, many of the chapters address areas of behavior that are familiar to scientists in particular fields, but do so using a variety of cross-disciplinary perspectives, which will prove stimulating for researchers in a range of academic subject areas, while helping to facilitate closer collaboration between biological and social scientists.

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Containment and permeable reactive barriers have come full circle as an acceptable environmental control technology during the past 30 years. As interest shifted back toward containment in the 1990s, the industry found itself relying largely on pre-1980s technology. Fortunately, in the past 10 years important advances have occurred in several areas of containment, most notably in the area of permeable barriers. A balanced presentation of what is known and not known, Barrier Systems for Contaminant Containment and Environmental Treatment provides a comprehensive report on the current state of the science and technology of waste containment. Comprehensive and easily read, this book is rich with discussions and references to literature. Setting the stage for how contaminants can get into the subsurface, the authors describe pathways and introduce the essential concepts of risk. They provide details on the current state of the art for performance prediction and clearly delineate the limitations in modeling specific situations. The book addresses the materials used in barriers, defines their properties, and explores how they perform in the field. It describes available technologies and addresses their applications to various types of barriers. Tackling perhaps the most challenging aspect of waste containment technology, the book includes two case studies that demonstrate the value of validating field performance.Subsurface containment and treatment barriers will continue to be a widely used environmental control technology in the years ahead. Representing the collective knowledge and efforts of leading experts from research, industry, and regulatory agencies, this book provides a valuable reference that helps to chart the way to successfully managing many contaminated sites.

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As the limits of electrical performance come within sight, photons are poised to take over for the electron. But the search continues for the materials, topologies, and fabrication technologies capable of producing photonic devices at a reasonable speed and cost. Taking a fundamentallook at the development of photonic technology from the macro- to the microscale, Applied Microphotonics introduces the major principles and technologies underlying the field.Following an overview of historical and commercial driving forces, the authors briefly review the underlying physics, emphasizing the practical and design implications for photonic systems. This general discussion lays the foundation for the remainder of the book, where the authors first introduce the photonic node and then discuss each subsystem in detail, including transmitters, couplers and switches, multiplexers and demultiplexers, receivers, amplifiers, and compensators. The following chapters explore new technologies such as photonic band gap structures, materials and fabrication processes, integration methodologies, and advanced devices such as photonic computers. The book concludes with a brief introduction to quantum photonics and a forward look at potential directions of photonics. Applied Microphotonics encapsulates the recent push toward all-optical networks and devices with an applications-oriented perspective. It is ideal for newcomers to the field as well as anyone curious to know how photonic technology can benefit their own field.

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