Search results for ""Author Leon""

Take a virtual tour of picturesque Havre de Grace, Maryland, a charming town on the Chesapeake Bay. Local history and charm are preserved through Victorian homes, waterfowl, festivals, and antique shops. Also stroll through Susquehanna State Park. Over 200 color photographs will help you experience the unique character and natural beauty of Havre de Grace.

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A collection of stories meant to be read while dining and drinking, the Dinner Pieces, or Intercenales, are among Alberti's most innovative works. They constitute an important monument in the history of comic writing and cover topics from politics to the arts to love. This edition presents a new translation and an authoritative Latin text.

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Since November 8, 1942, when American troops in Operation Torch first landed on the beaches of North Africa, almost a million Americans—military personnel and their dependents—have lived in Morocco. Their impact on the political and social evolution of Morocco has been significant, but historians and political scientists before this book had made little effort to chart its course or to assess its outcome. The naval base at Port Lyautey in Morocco was the first foreign base captured by American troops in World War II, and United States objectives in Morocco continued to be primarily military. In 1942, as the price for French support against the Axis, the United States pledged its support for the restoration of the prewar French colonial empire. In 1950, faced with the threat of Soviet aggression, the United States negotiated an agreement with France and built four United States Air Force bases in Morocco without consultation with or notification of the Moroccan government. In spite of its sterile diplomatic policy and both Communist and Moroccan nationalist demands for evacuation of United States military bases, the United States retained essential military facilities in Morocco for many years. Leon Blair concludes that American military personnel and their dependents favorably conditioned Moroccan public opinion. By their egalitarianism, humanitarianism, and evident interest, they reinforced the idealistic image of the United States that was held by the majority of Moroccans. These Americans were neither individually nor collectively conscious agents in a campaign to modify Moroccan public opinion; they were simply a Western window in the Arab world, through which two civilizations might view one another. In the long run, they made a greater contribution in peace than in war.

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As Multilateral Development Banks increasingly gained influence in shaping global development, transnational social movements pushed to hold them accountable for their human rights impact towards communities. Leon Valentin Schettler presents a novel causal mechanism of movement advocacy towards MDBs, combining disruptive and conventional tactics. Systematically comparing the evolution of human rights standards and complaint mechanisms over the last three decades, he reveals how the combination of 1) declining US hegemony, 2) counter-mobilization by China and 3) movement cooptation by the World Bank bureaucracy led to a dilution of human rights accountability in the 2010s.

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This edited monograph includes eight chapters, each discussing recent advancements in the fields of medicine and biology. Chapter One provides information on the mechanisms of polyurethane degradation. Chapter Two reviews the inhibitory effect of chlorogenic acid on metabolic syndrome-related vascular endothelial cell damage, type 2 diabetes, hypertension, and dyslipidemia. Chapter Three investigates the development of fatigue of rat skeletal muscle under the action of water-soluble pristine C60 fullerenes as powerful antioxidants. Chapter Four discusses advances in the generation of immune cells from pluripotent stem cells and the potential of chimeric antigen receptor cells in cancer treatment. Chapter Five describes the targeted delivery of immunosuppressants. Chapter Six focuses on the in vitro degradation of biopolymers using enzymes and microorganisms. Chapter Seven reviews the risk factors for hearing loss in infants admitted to the neonatal intensive care unit and the management of such patients detected with hearing loss. Finally, Chapter Eight describes recently developed methods and tools used in physiological studies of human sensory neurons induced from human pluripotent stem cells.

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Most American young people, like their ancestors, harbor desires for a worthy life: a life of meaning, a life that makes sense. But they are increasingly confused about what such a life might look like, and how they might, in the present age, be able to live one. With a once confident culture no longer offering authoritative guidance, the young are now at sea—regarding work, family, religion, and civic identity. The true, the good, and the beautiful have few defenders, and the higher cynicism mocks any innocent love of wisdom or love of country. We are supercompetent regarding efficiency and convenience; we are at a loss regarding what it’s all for.Yet because the old orthodoxies have crumbled, our “interesting time” paradoxically offers genuine opportunities for renewal and growth. The old Socratic question “How to live?” suddenly commands serious attention. Young Americans, if liberated from the prevailing cynicism, will readily embrace weighty questions and undertake serious quests for a flourishing life. All they (and we) need is encouragement.This book provides that necessary encouragement by illuminating crucial—and still available—aspects of a worthy life, and by defending them against their enemies. With chapters on love, family, and friendship; human excellence and human dignity; teaching, learning, and truth; and the great human aspirations of Western civilization, it offers help to both secular and religious readers, to people who are looking on their own for meaning and to people who are looking to deepen what they have been taught or to square it with the spirit of our times.

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This book includes five chapters, each representing a recent advancement in medicine and biology. Chapter One discusses future aspects of sports medicine and their applications. Chapter Two deals with clinical visual impairment in the elderly population resulting from neurodegenerative diseases such as Alzheimer's disease. Chapter Three reviews recent promising alternatives to protamine, which is currently used as a heparin antagonist but can cause dangerous side effects. Chapter Four describes the factors responsible for the development of diseases such as SARS, MERS, and Ebola. Finally, Chapter Five discusses the future applications of Drosophila melanogaster in neurobehavioural studies.

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In the first chapter, the authors intend to carry on a critical review of the different methods and approaches to determine the biomechanical output of joint stiffness, designated as dynamic joint stiffness by the authors. The second chapter summarizes several preceding articles on invasive procedures applied with questionable clinical indications in the former Soviet Union. The aim of the third chapter is to give information about how to use tacrolimus, in which type of glomerulonephritis and what are the treatment results, especially remission and relapse rates. In the fourth chapter, a ten-week experiment was conducted to assess the effect of supplementing Synechococcus sp. and Synechocystis sp. on the growth performance, haematology, serology and disease resistance in Oreochromis mossambicus. In the final chapter, discussions of the special properties of endothelial cells and their ability to generate the thrombotic microangiopathic syndrome and ARDS are undertaken based upon current knowledge of the capillary endothelial cells. Attempts are made to address the current pathophysiology of non-idiopathic thrombotic microangiopathy.

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Advances in Medicine and Biology. Volume 164 begins by proposing that first-line chemotherapy of metastatic colorectal cancer consensus molecular subtypes appears to be a prognostic factor that is able to provide information about growth rate. The authors go on to review the current and future applications of bioartificial grafts and conduits in the bridging of peripheral nerve defects. Ginsenoside Rb1 and phosphoramidon are studied in the zebrafish model of diabetic retinopathy, a progressive proliferative and non-proliferative disorder of retina with alterations of the blood-retinal barrier. Basic knowledge on the events from follicle development to implantation crucial to achieve successful conception as well as contraception is presented, describing the mechanism of contraceptive action of Chhaya. Hydroxydaunorubicin, also known as doxorubicin, a metabolite of Streptomyces peucetius and a prominent family member of anthracycline antibiotics is studied. The authors also review the possible mechanisms by which doxorubicin provokes concomitant side effects and clinical disorders, as well as the damage-assaying biochemical markers and the metabolites in these conditions. Updated data with a systematic search through the largest medical information databases is used to assess the therapeutic and preventive role in urinary incontinence of pelvic floor rehabilitation in pregnancy and postpartum. In closing, recent studies on the host and lactic acid bacteria as well as probiotic interactions in terms of molecular and cellular mechanisms of action via signaling pathways, apoptosis, and heat shock proteins are reviewed.

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Advances in Medicine and Biology. Volume 156 first defines endovascular aortic aneurysm repair as the treating of an abdominal aortic aneurysm by placing a stent graft device over guide wires inside the aneurysmal aorta, with the aim of achieving secure fixation and sealing at non-diseased proximal and distal landing zones. Abdominal aortic aneurysm has an atherosclerotic origin; however, rare cases are immune-related, such as those from IgG4 or infections. Among the infectious agents, the authors discuss tuberculosis bacillus, the Salmonella typhi, but also Streptococcus sp., Staphylococcus sp., Escherichia coli, Pseudomonas aeruginosa, and Treponema pallidum. Next, the authors discuss fentanyl, a piperidine derivative opioid analgesic agent that has clinical uses worldwide, originally developed by Janssen and his collegues (Janssen 1959, 309). The systematic name is N-(1-(2-phenethyl)-4-piperidinyl-N-phenylpropanamide. Since its discovery in the heroin supply in 1979, fentanyl and fentanyl analogs have been linked with epidemics of accidental overdose and death. More recently, the increased contamination of heroin with fentanyl and fentanyl analogs has been associated with accelerated national opioid overdose death rates in the United States. Following this, an overview of the systemic and topical corticosteroids used in dermatology is provided, and new classification methods to improve efficacy and minimize side effects are discussed. The authors go on to discuss prostatitis, an infectious disease caused by several bacteria. Approximately 8.2% of men have been affected by prostatitis which damages the ejaculatory ducts, causing infertility. The silver tree, Abies alba Mill. is a monoecious tree from the Pinaceae family. The fir has several uses in food and cosmetic industry, as well as in phototherapy and traditional medicine. As such, the antimicrobial activities of the essential oils of Abies species against some gram-positive and gram-negative bacteria and yeasts are explored. The penultimate chapter focuses on arthrosis or osteoarthritis of the knee, a local disease of the knee joint, and presents a clinical manifestation of degenerative changes in affected joints. The authors explore how procedures of physical therapy and rehabilitation alone or in combination with pharmacologic treatment can relieve pain and improve function in patients with knee osteoarthritis. The concluding chapter describes current concepts regarding the correlation between tinnitus and cochlear implants. Possible physiopathological mechanisms of tinnitus reduction after cochlear implant may involve several aspects, such as habituation, acoustic masking, direct electrical nerve stimulation and cortical reorganization.

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This collection begins by discussing bendamustine, a nitrogen mustard derivative that consists of a meclorethamine group, butyric acid and a benzimidazole ring. Bendamustine has been synthesized in 1963, but in recent years it has been shown to be effective in treating lymphoproliferative diseases and solid tumors. Additionally, the authors present the efficacy of structure variation of bendamustine for the enhancement of the lipid membrane partitioning and tissue penetration, as well as drug-likeness. A total of 10 novel compounds are presented, wherein seven have higher Log P values and three have lower Log P values than that of bendamustine. Advances in Medicine and Biology. Volume 149 also discusses metabolic syndrome, a growing major clinical challenge for global health resultant from over-consumption of energy and obesity. Following this, the authors address the importance of antimicrobial resistance in human and veterinary medicine, focusing on antimicrobial peptides such as nisin as therapeutic alternatives. A study is presented wherein it is concluded that oligodendrocyte dysfunction in multiple system atrophy significantly affects subcortical anatomical pathways. Moreover, the spatial patterns of the glial cytoplasmic inclusions in multiple system atrophy contrast with those reported for filamentous neuronal inclusions in other neurodegenerative diseases. Next, the authors summarize the recent discoveries expounding how β-cell identity and heterogeneity evolve in diabetes mellitus, discussing a new perspective of β-cell function salvage in diabetes mellitus development. Yeast cell cycle arrest and its consequences are analyzed in the subsequent chapter. Cell cycle arrest results in programmed cell death, such as apoptosis, wherein cells are made to commit suicide. The penultimate study evaluates the effect of anodal transcranial direct current stimulation on cognitive and neurophysiological functions in patients with moderate cognitive impairment. Lastly, to investigate the role of CD44 in the development of allergic respiratory inflammation, a mouse model of airway allergic inflammation induced by transnasal administration of helminthic and mite allergens is used to analyze bronchoalveolar lavage fluid and airway hyper responsiveness.

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