Search results for ""Author Leon""

This volume includes eight chapters which describe recent advances in medicine and biology. Chapter One summarises new therapeutics for the treatment of optic neuritis, a condition involving primary inflammation, demyelination, and axonal injury of the optic nerve. Chapter Two uses animal models of viral myocarditis to study the natural history, genetics, pathogenesis, and clinical manifestation of viral myocarditis in humans. Chapter Three evaluates the functions of fibroblast growth factors in physiological mechanisms, their role in maintaining homeostatic balance, their role in signal transduction regulation, metabolism and interactions between organisms, and their relationship with diseases. Chapter Four investigates the potential of antibiotics to fight against the inherently nonspecific adaptation mechanisms of bacteria. Chapter Five deals with new methodologies for drug development to counter the evolution of mechanisms to resist antibiotics such as efflux pumps in bacteria that cause infectious disease. Chapter Six concerns the development of new therapeutic strategies regarding the involvement of brain neuropeptides in alcohol use disorder. Chapter Seven examines growth promotion and changes in functional constituents through arbuscular mycorrhizal fungi symbiosis in Asian ginseng. Finally, Chapter Eight explicates procedures for postoperative care in thoracic surgery.

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This volume discusses the merits and demerits of currently available conventional cholera vaccine delivery systems and therapies, and the potential role of novel nanomaterials-based delivery approaches for the management of cholera. Cholera, the watery diarrhea caused by Vibrio cholerae, is a major public health issue in the developing world. V. cholerae is a gram negative, facultative anaerobic, aquatic bacterium with single polar flagellum and is a member of γ subdivision of the family Proteobacteriaceae. Following this, the structures and functions of human helicases and the 5-upstream regions of the encoding genes are classified for further investigation. Genetic studies have revealed that mutations in some of these genes are associated with certain human diseases, including Xeroderma Pigmentosum, Cockayne Syndrome and Werner Syndrome. The authors describe a practical exercise where the construction of a pharmacophore model is interpreted with the aid of 2-D structures, while the final model is used in a virtual screening to identify potentially active kinase inhibitors. The use of freely available software and web servers makes this exercise a useful and easily implementable resource for almost any undergraduate student. This compilation also addresses how folate intake during pregnancy is essential for adequate fetoplacental development and for the health of the baby. Neural tube defects are a preventable cause of mortality and morbidity, and the prevalence of neural tube defects has significantly decreased worldwide after the fortification of folic acid. Subsequently, the authors describe recent findings in the storage and supply site, localization, and imaging of high-density lipoprotein in human coronary arteries. In an effort to achieve less invasive surgery justified by better outcomes, lower hospital costs, patient recovery time and cosmetic results, the authors also review innovative surgical techniques such as minilaparoscopy, single incision laparoscopic surgery, natural orifice transluminal surgery and others that are being employed or expected to be the future. The concluding chapter describes several cases where Mycoplasma have led to the electronic contamination of prestigious public data stores.

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Advances in Medicine and Biology. Volume 155 reviews whether the non-surgical and non-pharmacological interventions commonly used for knee osteoarthritis patients are effective and, if effective, which ones are the most effective. For this, randomized controlled trials were identified through electronic databases. Following this, the authors discuss how the early identification of target subjects who are at high cardiometabolic risk is important for critical lifestyle interventions and pharmacological management strategies. Additionally, they discuss the diversity, biotechnological applications and sustainable bioproduction of chitinases enzyme from Streptomyces origin, as well as their properties, production and potential applications in the industrial and biotechnological spheres. New strategies such as the use of atomic force microscopy, the isolation of cardiomyocytes, primary culturing in different types of substrates as well as transcriptomic studies are enabling the understanding of how these cells can be affected by different pathologies. As such, in this compilation these issues are updated by analyzing how new approaches to basic aspects of the structure and physiology of cardiomyocytes can be of clinical relevance. This collection also discusses chitotriosidase and acidic mammalian chitinase belonging to the chitinase family. This family includes 18 chitinases united by the features of their molecular structure. Degenerative lumbar spondylolisthesis is a common, multifactorial process also associated with aging, which frequently causes central canal stenosis. Several types of interbody fusion procedures that may treat of degenerative lumbar spondylolisthesis are examined, particularly lateral lumbar interbody fusion. The final chapter explores the role surgical intervention plays in the diagnosis, staging, and treatment of malignant pleural mesothelioma.

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Volume 154 first compares the scleral buckle procedure to pneumatic retinopexy and vitrectomy for the repair of primary rhegmatogenous retinal detachment to evaluate patient outcomes, single surgery reattachment rate, and complications. Following this, the authors review recent advances in liver organoids differentiated from pluripotent stem cells and discuss the future directions of organoid technology. Additionally, the authors compare the efficacy of low-level red and infrared laser irradiation for the correction of adverse side effects in the oral mucosa in patients receiving (chemo)radiotherapy for oral and pharyngeal cancer. In vivo oral mucosa state monitoring is carried out in patients during the course of oral and pharyngeal cancer radiation/chemoradiation therapy using multimodal optical coherence tomography. An overview of the current methods used for diagnosing, classification of fractures, treatment, and prevention of periprosthetic femur fractures following total hip arthroplasty is provided. This collection also investigates the presence of kyphosis in adolescents and the association between the incidence of kyphosis and age, the average duration of the sports training, body mass index, weight, height and pulse in adolescents who have participated in karate, swimming and handball. The authors attempt to describe advancements in the electrochemistry of cytochrome P450 enzymes and study molecular aspects and catalytic behavior of enzymatic electrocatalysis. Moreover, a comprehensive overview of major causes of liver fibrosis, medicinal plants and the role of medicinal plants in combatting liver fibrosis is provided. Lastly, this compilation recapitulates the history of artificial intelligence in Chinese medicine, focusing on the way Chinese medicine is being revolutionized by this state-of-the-art technology, and how healthcare in China is influenced by various artificial intelligence systems.

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As ardent debates over creationism fill the front pages of newspapers, Genesis has never been more timely. And as Leon R. Kass shows in "The Beginning of Wisdom", it's also timeless. Examining Genesis in a philosophical light, Kass presents it not as a story of what happened long ago, but as the enduring story of humanity itself. He asserts that the first half of Genesis contains insights about human nature that "rival anything produced by the great philosophers." Kass here reads these first stories - from Adam and Eve to the tower of Babel - as a mirror for self-discovery that reveals truths about human reason, speech, freedom, sexual desire, pride, shame, anger, and death. Taking a step further in the second half of his book, Kass explores the struggles in Genesis to launch a new way of life that addresses mankind's morally ambiguous nature by promoting righteousness and holiness. Even readers who don't agree with Kass's interpretations will find "The Beginning of Wisdom" a compelling book - a masterful philosophical take on one of the world's seminal religious texts.

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The Plurality of Realities contains four texts by Leon Chwistek that deal with his original philosophical conception called the theory of plurality of realities. This collection is essential not only for understanding the full-fledged version of Chwistek’s conception but also for surveying its development over a span of five years (1916–1921). Reading these essays in chronological order allows us to notice all stages of its development, beginning with its first sketches, drawn in the book Meaning and Reality, where only two realities are considered, and finishing with Chwistek’s most famous essay, The Plurality of Realities, in which he discusses four different realities: the reality of things, the reality of physics, the reality of impressions, and the reality of imaginations. The collection is preceded by two introductory essays by Karol Chrobak. The first presents Leon Chwistek against the background of the intellectual, cultural, and political life of the interwar period in Poland. The second focuses on Chwistek’s conception of the plurality of realities and gives a critical account of its most widespread interpretations.

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"The pleasure of reading the Education is . . . the pleasure of seeing history come alive, of seeing it move, of seeing behind history to the actions and actors. It is the pleasure of seeing revealed the humanity so often concealed in history." -Alfred Kazin Henry Adams was one of the most powerful and original minds to confront the American scene from the Civil War to World War I. Though a man of the modern world, Adams remained in temperament a child of the 18th century, his political ideals shaped by his presidential ancestors, great-grandfather John Adams and grandfather John Quincy Adams. The Education of Henry Adams is both a brilliant memoir and a profound meditation on the extraordinary developments in science, politics, religion, and society that so transformed the world as he knew it. For almost thirty years, The Library of America has presented America's best and most significant writing in acclaimed hardcover editions. Now, a new series, Library of America Paperback Classics, offers attractive and affordable books that bring The Library of America's authoritative texts within easy reach of every reader. Each book features an introductory essay by one of a leading writer, as well as a detailed chronology of the author's life and career, an essay on the choice and history of the text, and notes. The contents of this Paperback Classic are drawn from Henry Adams: Novels, Mont Saint Michel, The Education, volume number 14 in the Library of America series. That volume is joined in the series by two companion volumes, numbers 31 and 32, Henry Adams: History of the United States During the Administrations of Thomas Jefferson and Henry Adams: History of the United States During the Administrations of James Madison.

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Leon "Locksmith" Rolle is one-quarter of the phenomenally successful band Rudimental. In this book, he shares his aspirational story. With chapters on mindset, self-belief and confidence, Leon encourages you to find balance and happiness, no matter what life throws at you.Leon grew up in Hackney, where he played semi-professional football and went on to form Rudimental with three childhood friends. He says: "Things weren’t always easy for me growing up, and I made a lot of mistakes. But I don’t regret any of it, because everything that’s happened has made me Locksmith, and that makes me proud. I want you to be proud of yourself too. You have the power to be great, and successes, mistakes and failures are all just a part of life. It's the journey that counts, because that's what makes you who you are."Let Leon's story inspire you to embrace life and fulfil your incredible potential.

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The assessment of bioequivalence is an important process whereby the bioavailability of a generic drug product is compared with its brand-name counterpart. Generic pharmaceutical products must be approved as therapeutic equivalents to the brand name alternative in order to be interchangeable. The demonstration of bioequivalence is an important component of therapeutic equivalence. Bioequivalence studies are very expensive, time consuming and always have the possibility of failure. The objective of this textbook is to describe some of those specific bioequivalence issues which need to be considered for the design and conduct of bioequivalence studies. By exploring scientific, legal, and international regulatory challenges, Generic Drug Development, discusses the use of alternative approaches to the measurement of plasma drug concentrations for the demonstration of bioequivalence, and covers bioequivalence procedures for drug products that are not easily assessed - based upon the physical and chemical properties of the active drug and the nature of the drug product.

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The Nuremberg Interviews reveals the chilling innermost thoughts of the former Nazi officials under indictment at the famous postwar trial. The architects of one of history's greatest atrocities speak out about their lives, their careers in the Nazi Party and their views on the Holocaust. Their reflections are recorded in a set of interviews conducted by a U.S. Army psychiatrist. Dr Leon Goldensohn was entrusted with monitoring the mental health of the two dozen German leaders charged with carrying out genocide, as well as that of many of the defence and prosecution witnesses. These recorded conversations have gone largely unexamined for more than fifty years.Here are interviews with some of the highest-ranking Nazi officials in the Nuremberg jails, including Hans Frank, Hermann Goering, Ernest Kaltenbrunner, and Joachim von Ribbentrop. Here, too, are interviews with lesser-known officials who were, nonetheless, essential to the workings of the Third Reich. Goldensohn was a particularly astute interviewer, his training as a psychiatrist leading him to probe the motives, the rationales, and the skewing of morality that allowed these men to enact an unfathomable evil. Candid and often shockingly truthful, these interviews are deeply disturbing in their illumination of an ideology gone mad.Each interview is annotated with biographical information and footnotes that place the man and his actions in their historical context and are a profoundly important addition to our understanding of the Nazi mind and mission.

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This collection sets out a range of perspectives on the challenges that the Caribbean is facing today, showing how the arts hold a crucial role in forging a more sustainable Caribbean community. It forcefully attests to the view that visual art in particular has a specific contribution to make and that this in turn means striving to foster a sustainable arts community that can contend with an environment of uneven infrastructure, opportunity and public awareness. Spanning the scholarly, artistic and professional fields of arts and heritage, this book compares two of the Caribbean’s key linguistic regions – the Anglophone and the Dutch – to address the themes of global-local relations, capital, patronage, morality, contestation, sustainability and knowledge exchange. The result is a milestone of collaboration from diverse global settings of the Caribbean and its diaspora, including Jamaica, the Bahamas, Barbados, Suriname, Curaçao, the Netherlands, UK, Germany and the US.

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‘…the free development of each is the condition for the free development of all.’ The Modern South African Edition of the Communist Manifesto Includes: Leon Trotsky’s Afrikaans Introduction to the 1937 edition with an English translation. Neville Alexander’s 2002 Introduction in isiZulu and English to the isiZulu translation of The Communist Manifesto. A new isiZulu translation of The Communist Manifesto. Jeremy Cronin’s Introduction to this edition. As the first in the new series RADICAL PASTS, RADICAL FUTURES, this edition of The Communist Manifesto is a vantage point from where to view the lives, work and creativity of ordinary South Africans in the years 1937, 2002 & 2022, and a prompt to visit and re-visit Marx & Engels’ urgent text.

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An up to date account of renewable sources of electricity generation and their integration into power systems With the growth in installed capacity of renewable energy (RE) generation, many countries such as the UK are relying on higher levels of RE generation to meet targets for reduced greenhouse gas emissions. In the face of this, the integration issue is now of increasing concern, in particular to system operators. This updated text describes the individual renewable technologies and their power generation characteristics alongside an expanded introduction to power systems and the challenges posed by high levels of penetrations from such technologies, together with an account of technologies and changes to system operation that can ease RE integration. Features of this edition: Covers power conditioning, the characteristics of RE generators, with emphasis on their time varying nature, and the use of power electronics in interfacing RE sources to grids Outlines up to date RE integration issues such as power flow in networks supplied from a combination of conventional and renewable energy sources Updated coverage of the economics of power generation and the role of markets in delivering investment in sustainable solutions Considers the challenge of maintaining power balance in a system with increasing RE input, including recent moves toward power system frequency support from RE sources Offers an insightful perspective on the shape of future power systems including offshore networks and demand side management Includes worked examples that enhance this edition’s suitability as a textbook for introductory courses in RE systems technology Firmly established as an essential reference, the Second Edition of Renewable Energy in Power Systems will prove a real asset to engineers and others involved in both the traditional power and fast growing renewables sector. This text should also be of particular benefit to students of electrical power engineering and will additionally appeal to non-specialists through the inclusion of background material covering the basics of electricity generation.

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