Search results for ""Author Leon V. Berhardt""

This volume includes five chapters dealing with some of the latest advances in medicine and biology. Chapter One pontificates on the impact of the sequencing of the human genome on the search for life in the universe. Chapter Two summarizes current understanding of how to assess endothelial dysfunction, main risk factors, mechanisms underlying its development, prognostic implications, and biomarkers. Chapter Three assesses the effects of the hormone irisin on glucose metabolism. Chapter Four highlights the common disorders that need to be considered as a differential diagnosis for neuromyelitis optica spectrum disorder and features that help in their differentiation. Finally, Chapter Five deals with tapered modular femoral components in revision total hip arthroplasty.

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This edited manuscript includes six chapters, each describing recent advancements in medicine and biology. Chapter One investigates the impact on psychopathology of adding lurasidone to clozapine for people with treatment-resistant schizophrenia. Chapter Two reviews some intestinal protozoa and their diseases in immunodeficient patients. Chapter Three addresses the general role of inflammasomes and reviews current knowledge of potential therapeutic application of inflammasomes in neurological disorders. Chapter Four looks at the role of ion channel activation and downstream signal transduction in modulating Sertoli cell behaviour to a final physiological response and its potential impact on spermatogenesis. Chapter Five includes a comprehensive view on sulphur-containing saponins and their mode of actions. Lastly, Chapter Six assesses the pathophysiological impacts of Spironucleus salmonis infection on the seawater adaptability of juvenile chum salmon.

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This monograph consists of six chapters, each describing recent advancements in medicine and biology. Chapter One details the use of radiology as an imaging method in diagnosis and risk-assessment of osteoporosis. Chapter Two describes research that aims to better understand the mechanisms involved in the onset of extrapyramidal side effects following treatment with antipsychotics. Chapter Three deals with issues related to endoscopic submucosal dissection (ESD), including diagnosis, endoknives, procedure, traction method, management of complications, and more. Chapter Four discusses ESD in the context of colorectal neoplasia. Chapter Five discusses estrogen receptor mutations that have been described in the ligand binding domain as well as the proposed treatments for patients with breast cancer ESR1 mutant-bearing tumors. Finally, Chapter Six discusses the role of estradiol in the regulation of the immune response of the host during parasitic infections and how estradiol affects parasite physiology.

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This monograph contains six chapters, each of which provides details about recent advancements in the field of medicine and biology. Chapter One describes the discovery of AZQ, a drug specifically designed to shut off genes that cause brain cancer. Chapter Two analyses the structure, stability, adaptation to extreme environments and the catalytic mechanism of α-helical membrane proteins. Chapter Three provides an up-to-date overview of artificial intelligence (AI) in assisted reproductive treatment (ART) clinics and explores how AI learns and develops a dataset to provide clinical guidance. Chapter Four consists of a study focused on the etiopathogenesis of primary open angle glaucoma using laboratory mice. Chapter Five presents and comments on the current evidence regarding diagnostics in patients with metastatic breast cancer based on circulating tumour cells (CTCs). Lastly, Chapter Six reviews the pathogenetic and clinical features of inner ear involvement in congenital cytomegalovirus (cCMV), the most frequent non-genetic cause of permanent sensorineural hearing loss in childhood.

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Advances in Medicine and Biology. Volume 170 begins by presenting the latest evidence that Alzheimer's disease-related proteins and their genes play a role in post-ischemic brain damage, and that an ischemic episode is an essential and leading provider of Alzheimer's disease development. The authors go on to review the pathophysiology, symptoms, epidemiology, analysis, and treatment of Alzheimer's disease. Important issues when appraising and interpreting studies on fertility awareness methods used for avoiding pregnancy are described, and correct clinical applications of fertility awareness methods for contraception are also discussed. The basic molecular pathology of human cancers is discussed, as well as rising technologies for tumour characterization and the role of molecular profiling in identifying potential targets for individualised treatment. Additionally, an overview of the various modalities for assessing the liver functional reserve in patients undergoing hepatic resection is provided. Lastly, data on the linearization of somatic growth plots in humans and rats is discussed, showing the existence of at least two ontogenetic transitions: juvenile and pubertal.

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This compilation opens with a review of the current knowledge regarding the impact of endocrine disruptors on human health, as well as the mechanisms contributing to it. The authors emphasize the evidence of aquaporin modulation by hypoxia and erythropoietin, as these water channels are increasingly valued as potential biomarkers of disease, as well as pharmacological targets for the treatment of brain and renal injuries, cardiovascular disorders and cancer. Later, the safety and tolerability of adalimumab demonstrated in pivotal phase III clinical trials is examined, along with long-term follow up data from open-label extensions and the ESPRIT registry. Adalimumab for the treatment of ankylosing spondylitis and peripheral spondyloarthritis is also discussed. The authors go on to study the types, causes, effect and problems related to polycystic ovary syndrome. The closing study deals with the relationship between reactive oxygen species and male fertility, providing some futuristic approaches for better research in the field.

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Volume 165 first presents promising information about the essential goal of effective and safe medication for target patients with the appropriate genotypes. The authors explore the diverse causes of neonatal leukemoid reaction in premature infants proposed by Hill and Duncan in 1941, such as intrauterine infection and maternal steroid administration. This compilation also explores hjypoxia-inducible factor-1, a key gene regulator for cellular adaptation to hypoxia which leads to a transcriptional response under physiological as well as pathological conditions. From a historical perspective, Wilms' tumor treatment is assessed, focusing on the different approaches of the two main groups, the Children's Oncology Group and the International Society of Paediatric Oncology. The genetics and genomics of Plasmodium, which include multiple parameters and factors affecting disease transmission, are assessed in an effort to enhance our knowledge about the disease. Following this, whole slide imaging or virtual microscopy is used for the quantitative evaluation of liver biopsy specimens of patients with chronic hepatitis. The closing study examines data which reveals changes in the functioning of the ceruloplasmin/transferrin system, decreasing the content of toxic ions of Fe2+ in the plasma of patients with Parkinson's disease. These changes are a pathogenetically significant factor of Parkinson's disease at all stages.

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Advances in Medicine and Biology. Volume 157 opens with a study wherein the authors use guinea pig airway smooth muscle to demonstrate that testosterone blocks L type voltage dependent Ca2+ channels. Furthermore, in vivo experiments with sensitized guinea pigs show that bronchospasm induced by antigenic challenge was abolished by testosterone and its 5α and 5β-dihydrotestosterone metabolites. Following this, the authors evaluate the structural features of skeletal muscles in children and adults with various pathologies of the musculoskeletal system based on ultrasonography, considering periods of natural growth and involutive changes. An overview of the current state of research on fluoxetine for the treatment of anxiety alone or combined with depression is provided, along with its possible side effects. Also provided is scientific information is regarding the neurobiological bases of depression and therapeutic effects of fluoxetine during the different periods of menopause. This information could be useful in pharmacological strategies for the treatment of depression occurring in the menopausal women. One chapter focuses on how improved direct access to the liver protected inside the rib cage can be obtained in laparoscopic liver resection using its specific "Caudal approach", decreasing the risk of refractory ascites and liver failure, especially in hepatocellular carcinoma patients with chronic liver diseases. The nucleolus is packed with proteins involved in ribosome function and biogenesis, as well as other proteins involved in cell-cycle regulation, senescence and stress response. However, little is known about the molecular mechanism of protein turnover in the nucleolus. As such, the authors discuss the nucleolus-localized protein degradation pathway, which is essential to ribosome production and cell-cycle progression. The concluding chapter focuses on the dye Congo red, which is used as a stain in microscopy to detect an abnormal material called amyloid. Amyloid consists of misfolded proteins that form fibrils which bind molecules of Congo red and orientate the molecules parallel to the long axis of the fibrils.

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This edited monograph includes eight chapters, each discussing recent advancements in the fields of medicine and biology. Chapter One provides information on the mechanisms of polyurethane degradation. Chapter Two reviews the inhibitory effect of chlorogenic acid on metabolic syndrome-related vascular endothelial cell damage, type 2 diabetes, hypertension, and dyslipidemia. Chapter Three investigates the development of fatigue of rat skeletal muscle under the action of water-soluble pristine C60 fullerenes as powerful antioxidants. Chapter Four discusses advances in the generation of immune cells from pluripotent stem cells and the potential of chimeric antigen receptor cells in cancer treatment. Chapter Five describes the targeted delivery of immunosuppressants. Chapter Six focuses on the in vitro degradation of biopolymers using enzymes and microorganisms. Chapter Seven reviews the risk factors for hearing loss in infants admitted to the neonatal intensive care unit and the management of such patients detected with hearing loss. Finally, Chapter Eight describes recently developed methods and tools used in physiological studies of human sensory neurons induced from human pluripotent stem cells.

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