Search results for ""Author Owen""

Beverley McLachlin was the first woman to be chief justice of the Supreme Court of Canada. Joining the Court while it was establishing its approach to the Canadian Charter of Rights and Freedoms, McLachlin aided the court in weathering the public backlash against controversial decisions during her tenure. Controversies in the Common Law explores Chief Justice McLachlin’s approach to legal reasoning, examines her remarkable contributions in controversial areas of the common law, and highlights the role of judicial philosophy in shaping the law. Chapters in this book span thirty years, and deal with a variety of topics – including tort, unjust enrichment, administrative law, and criminal law. The contributors show that McLachlin had a philosophical streak that drove her to ensure unity and consistency in the common law, and to prefer incremental change over revolution. Celebrating the career of an influential jurist, Controversies in the Common Law demonstrates how the common law approach taken by Chief Justice McLachlin has been successful in managing criticism and ensuring the legitimacy of the Court.

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An inventive collection of stories by one of the most prominent and acclaimed writers in Hungary today. The Birth of Emma K., a collection of twelve short stories rich with magic, introduces English-language readers to one of the most vibrant and original voices in contemporary Hungarian literature. Zsolt Lang's new collection opens with God sitting on a bench looking over Budapest; later, a Hungarian man who has stumbled into a Romanian music theory class suddenly finds he is able to speak expertly about Hungarian composer Bela Bartok-and in perfect Romanian; and even later, against all odds, the embryo of Emma fights for her future life from within the womb. Drifting between melancholic and witty, in sentences that are winding, subtle, and colloquial, Lang's stories are deeply rooted in Transylvanian culture and history. Reminiscent of the best writings of Irish modernist masters such as Samuel Beckett and Flann O'Brien, The Birth of Emma K. presents an unforgettable collage of human nature.

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The idea that the self is inextricably intertwined with the rest of the world—the “oneness hypothesis”—can be found in many of the world’s philosophical and religious traditions. Oneness provides ways to imagine and achieve a more expansive conception of the self as fundamentally connected with other people, creatures, and things. Such views present profound challenges to Western hyperindividualism and its excessive concern with self-interest and tendency toward self-centered behavior.This anthology presents a wide-ranging, interdisciplinary exploration of the nature and implications of the oneness hypothesis. While fundamentally inspired by East and South Asian traditions, in which such a view is often critical to their philosophical approach, this collection also draws upon religious studies, psychology, and Western philosophy, as well as sociology, evolutionary theory, and cognitive neuroscience. Contributors trace the oneness hypothesis through the works of East Asian and Western schools, including Confucianism, Mohism, Daoism, Buddhism, and Platonism and such thinkers as Zhuangzi, Kant, James, and Dewey. They intervene in debates over ethics, cultural difference, identity, group solidarity, and the positive and negative implications of metaphors of organic unity. Challenging dominant views that presume that the proper scope of the mind stops at the boundaries of skin and skull, The Oneness Hypothesis shows that a more relational conception of the self is not only consistent with contemporary science but has the potential to lead to greater happiness and well-being for both individuals and the larger wholes of which they are parts.

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The award-winning Curiositree: Natural World explores, through 67 exquisitely illustrated charts, the myriad ways in which plants and animals have adapted to survive. Discover the interconnectedness of the natural world and learn why living things look and behave the way they do in a series of visually compelling information charts, maps and cutaways, all illustrated in a nostalgic, vintage style. Packed with incredible facts about the natural world and the animals that populate it, the whole family will enjoy the full-page spreads grouped into the categories of habitats, species and adaptations.The jacket of this large-format book unfolds to a huge wall poster showing the brilliant adaptations of a range of birds. Use the coloured ribbons like a bookmark, or to mark your place so you can return to pages that you found especially interesting. Celebrate the extraordinary resourcefulness and resilience of the natural world with amazing facts about: Habitats, ecosystems and biodiversity Migrations, from the wildebeest of Africa to the red crabs of Christmas Island All types of camouflage, from predator-dazing zebra stripes to the fur of the Artic fox, which changes to white in winter to match the snow Life in the rainforest, the ‘lungs of our planet’ All sorts of seeds and their variety of ingenious designs Life cycles of creatures, from butterflies to the curious axolotl (a type of salamander) As the human species, Homo sapiens, are challenged now to find ways to live and survive in harmony with nature, curiosity will provide the answers. So, set out on your own adventure in this book, and discover why the natural world is worthy of your unending curiosity.

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Erin Hunter's #1 nationally bestselling Warriors series continues in Warriors: Omen of the Stars-now featuring fierce new art. The fourth book in this fourth series, Warriors: Omen of the Stars #4: Sign of the Moon, brings more adventure, intrigue, and thrilling battles to the epic world of the warrior Clans. As the dark forces that have come between the four warrior Clans grow stronger, Jayfeather is summoned to the mountains by a desperate plea-the Tribe of Rushing Water is on the brink of being lost forever.

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Negotiating Boundaries: Identities, Sexualities, Diversities is a collection of essays by contributors from—and/or on—societies across the world: Boznia-Herzogovinia, Croatia, France, Iran, The Netherlands, New Zealand, Poland, South and West Africa, the UK and the USA. They are from a range of academic disciples—English Literature, Islamic and Middle Eastern Studies, Literary and Cultural Studies, Modern Languages, Religious Studies, Social Anthropology, Social Policy, Sociology and Theology. This level of diversity has resulted in the most wide-ranging volume ever published in the social sciences and humanities around the concept of "Boundaries". The book is at the cutting edge of intellectual thinking on personal and social "boundaries" applied to such areas as: Art, Genocidal Rape, Identities, God/Godde, Lesbianism, Literature, Men in "Women's Professions", Muslim women in Muslim and non-Muslim countries, Nationalism and Symbolism, Poetry, Religion, Sexual Harassment, Sexuality, Women in Science, Transgenderism, Virginity Testing and War.This range of contributors, locations and topics could have resulted in an incoherent volume with appeal to only a somewhat esoteric readership. However, the skilful use of the concept of "Boundaries" not only gives this book structured coherence, but makes it important reading for a wide range of academics, theorists and researchers in a diversity of disciplines."This is a lively, engaged, nuanced portrayal of the struggles around identity, inequality and domination. Ambitious in its scope – international, interdisciplinary and multi-dimensional in its social focus, Identities, Sexualities, Diversities offers a powerful picture of struggle and the pursuit of change, through the conceptual lens of boundaries. This collection explores the diverse ways boundaries operate, bringing new insights and questions to an established debate. It also, importantly, explores how boundaries can provide bridges. Thus, through its interweaving of theory and empirical analysis, and through its stories of bodies, texts, work, sexual expression, self-presentation, and changing values, Identities, Sexualities, Diversities offers a text that is reflexive, analytically thoughtful, and, significantly, hopeful.”—Davina Cooper, Professor of Law and Political Theory, Director of AHRC Research Centre for Law, Gender and Sexuality, Kent Law School, University of Kent“This is a fascinating collection of papers that provides new and important insights into the variety and natures of boundaries around ethnicity, identity and sexuality. Using the complex concept of boundaries the writers explore identities, sexualities and diversities through boundary crossings, contested boundaries, oppressive boundaries and creative, resistant boundaries. This provides a wonderful, coherent engagement with some of the key struggles at the present time over contested territory at personal and global levels. The range of articles ensures that these debates are contextualised in particular societies and cultures providing a rich source of theoretical material that helps our understandings of these complex and crucial issues. The theoretical rigour and fascinating insights presented in this edited book deserves a wide readership from those involved in the social sciences, women’s studies, the humanities and all those interested in transgressing conventional boundaries of scholarship”.—Sheila Scraton, Pro-Vice Chancellor, Director of University Research, Professor of Leisure and Feminist Studies, Leeds Metropolitan University.

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“Lark's artwork is fabulous, capturing both the scenes of violence and those of introspection, in which Forever tries to accept who she is and how she feels about it. It's top-notch SF worldbuilding. With an introduction by Warren Ellis.” - Publishers WeeklyThis prestige hardcover collects the first two arcs of the critically acclaimed and New York Times bestselling series; “Family,” which introduces Forever Carlyle and her Family as they are brought to the brink of war in a future of economic collapse; and “Lift,” where Forever uncovers a terrorist plot against her Family while another family altogether, the Barrets, take desperate measures to escape their life of poverty. PLUS! Never-before-seen work by Michael Lark and graphic designer Eric Trautmann, and exclusive world-building content. Collects Lazarus #1-9 with four-page preview and additional content.

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Spring has sprung and the Corps of Discovery is closing in on the Pacific! But new beginnings mean new horrors for Lewis and Clark, and out on the American plains, a sleeping beast has awoken!Collects MANIFEST DESTINY #37-42

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Politics in the European Union is an accessible and comprehensive introduction to the EU. Unique in its in-depth coverage of the history of the EU, the book explores a wide range of topics including institutions and policies, making it a complete guide to understanding the complex nature of the EU. Now in its fifth edition, the text has been fully updated to include coverage of Brexit, the refugee crisis, and political developments within member states. The text is enriched with a wide range of learning features, including end of chapter questions, which are designed to stimulate critical thinking, suggested further reading, EU timelines, and illustrative figures to help students take their learning further.

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With investigations into everything from black holes to exoplanets, the Hubble Telescope has changed not only the face of astronomy but also our very sense of being in the universe. On the 30th anniversary of its launch into low-earth orbit, this updated edition of Expanding Universe presents 30 brand new images, unveiling more hidden gems from the Hubble’s archives. Ultra-high resolution and taken with almost no background light, these pictures have answered some of the most compelling questions of time and space while also revealing new mysteries, like the strange “dark energy” that sees the universe expanding at an ever-accelerating rate. The collection is accompanied by an essay from photography critic Owen Edwards and an interview with Zoltan Levay, who explains how the pictures are composed. Veteran Hubble astronauts Charles F. Bolden, Jr. and John Mace Grunsfeld also offer their insights on Hubble’s legacy and future space exploration.

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Essentials of Chemistry: General, Organic, and Biochemistry, Volume I provides students with a brief yet complete guide to foundational knowledge and concepts in chemistry.The opening chapter discusses the atom, with content on atomic theory, elements and nuclides, substances and mixtures, energy changes, and more. Additional chapters address chemical elements and the periodic table, bonds and compounds, chemical changes, chemical calculations, and aqueous solutions. Students learn about the states of matter; acids, bases, and salts; and nuclear chemistry. The closing chapter presents an introduction to organic chemistry. Each chapter features a Threads from Previous Chapters section that highlights information from previous chapters that is necessary for full comprehension of the present chapter; a Setting the Stage section to prepare students to learn; learning objectives; a chapter summary; skill-check exercises; and end-of-chapter concept reviews. Appendices at the back of the book provide solutions to odd problems for all problem sets throughout the text.Essentials of Chemistry is the first textbook in a two-volume series designed to help students learn and apply critical information and skillsets within the discipline.

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Erin Hunter's #1 nationally bestselling Warriors series continues in Warriors: Omen of the Stars-now featuring fierce new art. The third book in this fourth series, Warriors: Omen of the Stars #3: Night Whispers, brings more adventure, intrigue, and thrilling battles to the epic world of the warrior Clans. As tensions grow between the Clans, Jayfeather, Lionblaze, and Dovepaw realize that evil is sometimes no more than a whisker's length away. Meanwhile, one cat will make a stand for what is right-and another may be lost forever.

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'We build "new into old"': since Chris Dyson set up his own practice in 2004, he has gained a reputation as one of the foremost historic conservation architects, poetically adapting listed buildings for the 21st century. Yet the vigour and originality he brings to his work is far from a conventional conservation approach. Dyson’s is an architecture seemingly with no rules, yet at the same time marked by a recurring interest in the interactions between people and city, culture and community. Dyson’s work is indelibly associated with Spitalfields, having lived and worked there since 1990, and it’s a place that provides a fitting metaphor for his architecture. Over its history Spitalfields has been subject to recurring waves of new people and cultures, which has created somewhere defined by its rich cultural and material layers. And so with Dyson’s architecture, in which, even with new-build projects, there’s an overriding sense of different elements – be they material, temporal or cultural – coming together into coherent wholes. Dyson’s is that rare thing: architecture that feels old and new at the same time. This volume is the first sustained critical analysis of Chris Dyson Architect’s philosophy, approach and body of work, focusing on their particular expertise in being sensitive to a sense of place, history and heritage.

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Erin Hunter's #1 nationally bestselling Warriors series continues in Warriors: Omen of the Stars-now featuring fierce new art. The fifth book in this fourth series, Warriors: Omen of the Stars #5: The Forgotten Warrior, brings more adventure, intrigue, and thrilling battles to the epic world of the warrior Clans. A divided StarClan has driven a deep rift between the warrior Clans, and the spirits of the Dark Forest are gaining strength. Now the warrior cats must decide whose word they can trust-before it's too late.

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The mysterious world of Minecraft is just waiting to be explored. But danger lurks around every corner and survival can prove difficult for even the bravest adventurer. The official Minecraft Guide from Mojang will help you to survive and thrive. You'll learn how to find resources, craft equipment and protect yourself from hostile mobs.

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A haunting Modernist masterpiece and the inspiration for Francis Ford Coppola's Oscar-winning film Apocalypse Now, Heart of Darkness explores the limits of human experience and the nightmarish realities of imperialism. Conrad's narrator Marlow, a seaman and wanderer, recounts his physical and psychological journey in search of the infamous ivory trader Kurtz: dying, insane, and guilty of unspeakable atrocities. Travelling upriver to the heart of the African continent, he gradually becomes obsessed by this enigmatic, wraith-like figure. Marlow's discovery of how Kurtz has gained his position of power over the local people involves him in a radical questioning, not only of his own nature and values, but also those of western civilisation. Part of a major series of new editions of Conrad's most famous works in Penguin Classics, this volume contains Conrad's Congo Diary, a chronology, further reading, notes, a map of the Congo, a glossary and an introduction discussing the author's experiences in Africa, the narrative and symbolic complexities of Heart of Darkness and critical responses to the novel.Edited with an introduction by Owen Knowles'Seems to reach into the heart of Conrad himself' Peter Ackroyd

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This handy, well illustrated guide covers all aspects of patient examination. Carry this practical text with you so you can review the questions you should include as part of your history taking, the examination techniques you should use for different body systems and the presenting signs of common disorders. The new fourth edition includes over 130 colour illustrations as well as text boxes to aid revision and help in daily clinical duties. The history-taking and examination coverage will be invaluable to students faced with real-life patients for the first time by highlighting the most things to remember The signs & symptoms sections describe the most important diseases associated with each body system The various icon boxes highlight and summarise information on a range of issues relevant to history and examination: the elderly, emergency situations, Questions to Ask, etc Colour photographs depict the clinical manifestations as they present in real-life and 'real-life' examination techniques Colour diagrams clarify examination technique . Fully updated in line with the accompanying textbook Clinical Examination . Increased emphasis on patient communication, especially in the general practice setting . Two new authors join the team bringing additional expertise to the Pocket Guide

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In the global North the commoditization of creativity and knowledge under the banner of a creative economy is being posed as the post-industrial answer to dependency on labour and natural resources. Not only does it promise a more stable and sustainable future, but an economy focused on intellectual property is more environmentally friendly, so it is suggested. Contested Powers argues that the fixes being offered by this model are bluffs; development as witnessed in Latin American energy politics and governance remains hindered by a global division of labour and nature that puts the capacity for technological advancement in private hands. The authors call for a multi-layered understanding of sovereignty, arguing that it holds the key to undermining rigid accounts of the relationship between carbon and democracy, energy and development, and energy and political expression. Furthermore, a critical focus on energy politics is crucial to wider debates on development and sustainability. Contested Powers is essential reading for those wondering how energy resources are converted into political power and why we still value the energy we take from our surroundings more than the means of its extraction.

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Is Scottish independence incompatible with ‘Labour values’?Are ‘Labour values’ being realised within the Union?How much really divides Yes campaigners from Labour voters?Why Not? Scotland, Labour and Independence is a passionate and often personal appeal to Labour voters (and other progressive Scots) to consider the social, economic and political gains that could be won with Scottish self-government. Bringing together a range of diverse voices – some from within the Labour Party, some from within the SNP, some from the non-aligned Left – it presents the social justice case for a Yes vote and argues that independence offers the clearest route forward for socialist and centre-left Scotland.Urgent, original and provocative, Why Not? is a vital contribution to the independence debate – and essential reading for all Scots.

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There is now a considerable literature on chemical ecology, which had its beginnings in the study of insect pheromones. This beginning was possible only by combining the disciplines and techniques of biology and chemistry. For a biologist, it is difficult to understand the time­ frames of analytical and synthetic chemistry. A compound may take days to characterize and be available in minutes from a bottle on the shelf, or it may take years to characterize and synthesize. Chemists have a similar frustration: after an intense programme of work, the insect in question may not emerge for many months. study are, however, The rewards of integrated interdisciplinary considerable, because they allow us to understand many facets of insect behaviour and consequently to control that behaviour for our own ends. In this book, we have set out to explain the results of research from chemical and biological perspectives, and see how the knowledge gained has led to novel techniques that can be used in insect pest management and insect control. An important part of understanding insect chemical ecology involves the understanding not only of new concepts but of the vocabularies used by scientists specializing in different fields. It will be clear that the three sections of this book have been written by three different people: an insect behaviourist, an organic chemist and a biologist in industry.

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The “happiness agenda” is a worldwide movement that claims that happiness is the highest good, happiness can be measured, and public policy should promote happiness. Against Happiness is a thorough and powerful critique of this program, revealing the flaws of its concept of happiness and advocating a renewed focus on equality and justice.Written by an interdisciplinary team of authors, this book provides both theoretical and empirical analysis of the limitations of the happiness agenda. The authors emphasize that this movement draws on a parochial, Western-centric philosophical basis and demographic sample. They show that happiness defined as subjective satisfaction or a surplus of positive emotions bears little resemblance to the richer and more nuanced concepts of the good life found in many world traditions. Cross-cultural philosophy, comparative theology, and social and cultural psychology all teach that cultures and subcultures vary in how much value they place on life satisfaction or feeling happy. Furthermore, the ideas promoted by the happiness agenda can compete with rights, justice, sustainability, and equality—and even conceal racial and gender injustice.Against Happiness argues that a better way forward requires integration of cross-cultural philosophical, ethical, and political thought with critical social science. Ultimately, the authors contend, happiness should be a secondary goal—worth pursuing only if it is contingent on the demands of justice.

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Actors fascinate us in part because they live out the truths we cannot - or do not - want to live out ourselves. In his latest book, acclaimed photographer Howard Schatz develops upon his well-received monthly feature for Vanity Fair,"In Character." Schatz' mastery of his craft is demonstrated as he himself acts, taking on the role of a director and giving his subjects detailed situations to explore, which are listed with the resulting image.The actors featured here - including John Malkovich, Pierce Brosnan, Michael Douglas, Colin Firth, Laurence Fishburne, Whoopi Goldberg, Michael C. Hall, Hugh Laurie, Amy Poehler, and Geoffrey Rush, among other illustrious greats - demonstrate their skill for improvisation while Schatz captures the complexity of their emotional and physical range. This inventive collection is a richly entertaining revelation of the fantasy of transformation. Schatz does not simply create characters from these actors - he helps to reveal their humanity.

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Drawing on a trove of previously confidential data, Strained Relations reveals the evolution of US policy regarding currency market intervention, and its interaction with monetary policy. The authors consider how foreign-exchange intervention was affected by changing economic and institutional circumstances - most notably the abandonment of the international gold standard - and how political and bureaucratic factors affected this aspect of public policy.

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The Sustainable Development Goals, adopted by the United Nations in 2015, comprise an ambitious and sweeping agenda that unites economic, social, and environmental aims. What resources do the world’s religious and secular traditions offer in support of these objectives? Which principles do these traditions hold in common, and how can these shared values help advance global goals?This book presents an in-depth and deeply engaged conversation among interfaith religious leaders and interdisciplinary scholars and practitioners in pursuit of an ethical consensus that could ground sustainable development efforts. Drawing on more than two years of close-knit discussions convened by Jeffrey D. Sachs and Marcelo Sánchez Sorondo, it offers an extensive and inclusive vision of how to promote human flourishing. The book features theological, philosophical, and ethical deliberations of great diversity and depth on the challenges of sustainable development, addressing questions of poverty, environmental justice, peace, conflict, and the future of work. It includes consensus statements on the moral imperatives of sustainable development, introductions to seven major religious traditions and their conceptions of the common good, and thematic reflections. Wide-ranging and urgent, this book represents a major contribution to interreligious dialogue and to the articulation of a shared global ethics.The book features a foreword by Pope Francis and Ecumenical Patriarch Bartholomew.

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The revised and updated Third Edition of Bovine Surgery and Lameness offers veterinarians a concise text ideal for use in the field. Offers a fully revised edition of the popular and well-respected book on bovine surgery and lameness Presents a practical quick-reference guide ideal for the field veterinarian Covers both common surgical procedures and the latest information on combating lameness Written by an expert team of international authors Includes access to a companion website offering video clips

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Inspired by the authors’ real lives, this picture book shares what sound means for one young deaf boy as he experiences the world with cochlear implants.Most people either can or cannot hear sound . . . but some people can do both! Meet a deaf boy with cochlear implants as he moves about his day. Sometimes he prefers not to hear, but when he wants to connect with the hearing world, he puts on his cochlear implants. How could he explain to his hearing parents what the absence of sound is like? Suddenly he has an idea—the best way he knows how to share this part of him with those he loves.With whimsical, bright illustrations and lyrical words, Sound Switch Wonder is a sweet and gentle story about sharing and embracing differences.

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This selection of poetry and prose by Ghalib provides an accessible and wide-ranging introduction to the preeminent Urdu poet of the nineteenth century. Ghalib's poems, especially his ghazals, remain beloved throughout South Asia for their arresting intelligence and lively wit. His letters-informal, humorous, and deeply personal-reveal the vigor of his prose style and the warmth of his friendships. These careful translations allow readers with little or no knowledge of Urdu to appreciate the wide range of Ghalib's poetry, from his gift for extreme simplicity to his taste for unresolvable complexities of structure. Beginning with a critical introduction for nonspecialists and specialists alike, Frances Pritchett and Owen Cornwall present a selection of Ghalib's works, carefully annotating details of poetic form. Their translation maintains line-for-line accuracy and thereby preserves complex poetic devices that play upon the tension between the two lines of each verse. The book includes whole ghazals, selected individual verses from other ghazals, poems in other genres, and letters. The book also includes a glossary, the Urdu text of the original poetry, and an appendix containing Ghalib's comments on his own verses.

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Economists are increasingly turning their attention to the measurement and causes of health inequality. This is in response to widespread concern that health disparities reflect social injustices but is also part of the trend away from the narrow focus on inequality in income to the more encompassing analysis of inequality in wellbeing. Researchers interested in the extent and causes of variation in wellbeing cannot but turn their analytical gaze on health inequalities. This volume contains methodological and empirical contributions from leading experts in health economics and economic inequality that add further momentum to a thriving field of research. The focus is on methods for the measurement of health inequalities (income related, multidimensional and inequalities of opportunity) as well as the analysis of their causes. The collection is essential reading for researchers already working on health inequality and provides an immediate reconnaissance of the frontiers for those entering this exciting field.

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Artist, diarist, collector, and writer Peter Beard (1938-2020) fashioned his life into a work of art; the illustrated diaries he kept from a young age evolved into a serious career as an artist and earned him a central position in the international art world. He collaborated with Francis Bacon and Salvador Dalí, he made diaries with Andy Warhol, worked on books with scientists like Dr. Norman Borlaug, Dr. Richard Laws, and Alistair Graham, and toured with Truman Capote, Terry Southern, and the Rolling Stones—all of whom are brought to life, literally and figuratively, in his work. He delved into the world of fashion for its beautiful women, taking Vogue stars like Veruschka to Africa and bringing new ones back to the U.S. with him. After spending time in Kenya and striking up a friendship with the author Isak Dinesen (Karen Blixen) in the early 1960s, Beard bought 50 acres next to her farm with the stipulation that he would film and write about the land and its flora and fauna. He witnessed the dawn of Kenya’s population explosion, which challenged finite resources and stressed animal populations—including the starving elephants of Tsavo dying by the tens of thousands in a wasteland of eaten trees. So he documented what he saw—with diaries, photographs, and collages. He went against the wind in publishing unique and sometimes shocking books of these works, including The End of the Game. The corpses were laid bare; the facts carefully recorded, sometimes in type and often by hand. Beard used his photographs as a canvas onto which he superimposed multi-layered contact sheets, ephemera, found objects, newspaper clippings that are elaborately embellished with meticulous handwriting, old-master inspired drawings, and often swaths of animal blood used as paint.

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Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies A thorough compilation of the many scientific breakthroughs in the ongoing development of precision cancer therapies related to lymphoma Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies: From Concept to Practice focuses on lymphoma, an area which has seen a remarkable number of breakthroughs in the ongoing development of precision cancer therapies. Each section on a specific biology or class of drugs has an introductory chapter written by an authority in the field, exclusively focused on the science and its relevance to cancer biology. This approach addresses the need for scientists, physicians, and the private sector to understand the broader context of the extraordinary advances that have produced such astonishing advances in the disease. The work primarily focuses on how to understand and translate fundamental principles of basic science into information that can be directly applied to patients – hence the subtitle, From Concept to Practice. To aid in readers’ comprehension, the first page of each chapter contains a box entitled ‘Take Home Points’. This short text will highlight the major unique points about the information contained within the chapter. Some of the key topics addressed in the work are as follows: Biological basis of the lymphoid malignancies: fundamental principles of lymphomagenesis and molecular classification of lymphoid malignancies Targeting programmed cell death: principles for understanding the many types of cell death and promising combinations of drugs targeting apoptosis Targeting the PI3K pathway: understanding the intricacies of this complex biology and precisely how targeted drugs can be leveraged therapeutically Targeting the cancer epigenome: pharmacologic features of drugs targeting the epigenome and future prospects for targeting various aspects of epigenetic control Targeting the tumour proteome: understanding the mechanisms of protein degradation in cancer including both older drugs like proteasome inhibitors, and newer PROTAC based approaches Written primarily for scientists and physicians in both the public and private sectors, Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies: From Concept to Practice is a comprehensive reference work for those interested in the growing area of Precision Cancer Therapies. Seamlessly integrating the basic and applied science, this volume will be an indispensable reference for those interested in translating the most important advances in science to innovative novel treatments for patients.

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THE PERIPHERAL T-CELL LYMPHOMAS Provides a comprehensive look at Peripheral T-Cell lymphomas, including the group’s unique geographic distribution, underlying genetics, and novel treatments Peripheral T-Cell lymphomas (PTCL) are a diverse group of lymphoid malignancies that develop from mature T cells and natural killer (NK) cells. PTCL represent 10-15% of all cases of non-Hodgkin lymphoma in the US, and up to 20-25% of cases in South America, Asia, and other regions around the world. The role of different etiologic factors and the variation of geographic distribution makes PTCL one of the most difficult types of cancer to understand and treat. For the first time in a single volume, The Peripheral T-Cell Lymphomas presents a comprehensive survey of this complex and rare group of blood cancers. Featuring contributions from an international team of leading authorities in the various aspects of PTCL, this authoritative text covers biology, epidemiology, classification, approved and emerging drugs, molecular genetics, and more. Detailed clinical chapters address diagnosis, prognosis, and treatment of each of the major PTCL subtypes identified in the 2018 WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. This much-needed resource: Covers the biological basis, epidemiology, classification, and treatment of PTCL Discusses the future of the field, including global collaboration efforts and novel approaches to PCTL Explores the role of biologics in PTCL and autologous and allogeneic stem-cell transplantation Offers new insights on molecular pathogenesis, innovative therapeutics, and novel drug combinations Features contributions from the Chairs The T-Cell Lymphoma Forum: the world’s largest meeting focused on PTCL Reflecting the unique epidemiology and genetic diversity of the PTCL, The Peripheral T-Cell Lymphomas is an indispensable source of data, insight, and references for the medical community, particularly oncologists and hematologists in both training and practice.

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Shoot for the Stars Blast off into a galaxy of adventure with the Starfinder Roleplaying Game! Step into your powered armor and grab your magic-infused laser rifle as you investigate the mysteries of a weird universe with your bold starship crew. Will you delve for lost artifacts in the ruins of alien temples? Strap on rune-enhanced armor and a laser rifle to battle undead empires in fleets of bone ships, or defend colonists from a swarm of ravenous monsters? Maybe you'll hack into the mainframe of a god-run corporation, or search the stars for clues to the secret history of the universe or brand new planets to explore. Whether you're making first contact with new cultures on uncharted worlds or fighting to survive in the neon-lit back alleys of Absalom Station, you and your team will need all your wits, combat skill, and magic to make it through. But most of all, you'll need each other. This massive 528-page hardcover rulebook is the essential centerpiece of the Starfinder Roleplaying Game, with rules for character creation, magic, gear, and more-everything you need to play Starfinder as either a player or Game Master! The next great adventure in science-fantasy roleplaying takes off here, and the Starfinder Core Rulebook is your ticket to a lifetime of adventure amid the stars! Inside this book, you'll find: • All of the rules you need to play or run a game of Starfinder. • Seven character classes, from the elite soldier and stealthy operative to the physics-hacking technomancer and mind-bending mystic. • Character races both new and classic, from androids, insectile shirrens, ratlike ysoki, and reptilian vesk to the dwarves and elves of the distant future. • An in-depth exploration of the Starfinder setting, including its planets, gods, factions, and threats. • Hundreds of weapons, spells, technological gadgets, magic items, and other options to outfit any character. • Complete rules for starships, including customization and starship combat.• Rules and tips on using Pathfinder RPG content with Starfinder.

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R is rapidly becoming the standard software for statistical analyses, graphical presentation of data, and programming in the natural, physical, social, and engineering sciences. Getting Started with R is now the go-to introductory guide for biologists wanting to learn how to use R in their research. It teaches readers how to import, explore, graph, and analyse data, while keeping them focused on their ultimate goals: clearly communicating their data in oral presentations, posters, papers, and reports. It provides a consistent workflow for using R that is simple, efficient, reliable, and reproducible. This second edition has been updated and expanded while retaining the concise and engaging nature of its predecessor, offering an accessible and fun introduction to the packages dplyr and ggplot2 for data manipulation and graphing. It expands the set of basic statistics considered in the first edition to include new examples of a simple regression, a one-way and a two-way ANOVA. Finally, it introduces a new chapter on the generalised linear model. Getting Started with R is suitable for undergraduates, graduate students, professional researchers, and practitioners in the biological sciences.

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This selection of poetry and prose by Ghalib provides an accessible and wide-ranging introduction to the preeminent Urdu poet of the nineteenth century. Ghalib's poems, especially his ghazals, remain beloved throughout South Asia for their arresting intelligence and lively wit. His letters—informal, humorous, and deeply personal—reveal the vigor of his prose style and the warmth of his friendships. These careful translations allow readers with little or no knowledge of Urdu to appreciate the wide range of Ghalib's poetry, from his gift for extreme simplicity to his taste for unresolvable complexities of structure.Beginning with a critical introduction for nonspecialists and specialists alike, Frances Pritchett and Owen Cornwall present a selection of Ghalib's works, carefully annotating details of poetic form. Their translation maintains line-for-line accuracy and thereby preserves complex poetic devices that play upon the tension between the two lines of each verse. The book includes whole ghazals, selected individual verses from other ghazals, poems in other genres, and letters. The book also includes a glossary, the Urdu text of the original poetry, and an appendix containing Ghalib's comments on his own verses.

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