Search results for ""Author Francis"

The volume brings together seventeen studies on Avicenna by Dimitri Gutas, written over the past twenty-five years. They aim to establish Avicenna’s historical and philosophical context as a means to determining his philosophical project and the orientations of his thought. They deal with his life and works, his method, his epistemology, and his later reception in the Islamic world, ending with a programmatic essay on the state of the field of Avicennan studies and future agenda. Occasioned by issues raised in Gutas’s monograph on Avicenna and the Aristotelian Tradition (whose second edition has just appeared), they form a substantive complement to it. For this reprint, a number of the essays have been reset and accordingly revised and updated. Provided with exhaustive indexes of names, places, subjects, and technical terms, the volume constitutes a new and major research tool for the study of Avicenna and his heritage. (CS1050).

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The modern welfare state is indeed one of the greatest achievements of the post-war 20th century. With its key aims of eradicating the five giant social ills of Want, Ignorance, Disease, Squalor and Idleness, it aimed to providing a minimum standard of living, with all people of working age paying a weekly contribution; in return, benefits would be paid to anyone who was sick, unemployed, retired or widowed. The modern welfare state, therefore, is about maintaining a delicate equilibrium between dependent social groups on the one hand and the active working classes on the other. In the case of old-age security, this balance is being achieved (or not) by the so-called Generation Contract. This social pact is more of an implicit, unwritten and unspecified social contract. This ground-breaking book demonstrates how countries are addressing population-ageing challenges in depth, using the case study of Austria to gain the required complexity and differentiation in a comparative European framework of empirical evidence. This is a broad social science study in political economy and sociology, not an economic analysis. Though focusing on pensions, it centres on the (im)balance between work and non-work, issues of health, work ability, employability, and benefit receipt from old-age security to disability allowance. It will be required reading for all sociologists and social policy experts and academics working within this area.

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This book provides a unique, authoritative and detailed examination of the physiological and clinical consequences of human exposure to high G forces. Pilots of military fast jets, civilian aerobatic pilots and astronauts during the launch and re-entry phases of spaceflight are frequently and repetitively exposed to high G forces, for which the human body is not fundamentally designed. The book examines not only the nature of the high G environment, but the physiological effects of exposure to high G on the various systems of the human body. In particular, the susceptibility of the human cardiovascular system to high G is considered in detail, since G-Induced Loss of Consciousness (G-LOC) is a serious hazard for high G pilots. Additionally, the factors that influence tolerance to G and the emerging scientific evidence of physiological adaptation to high G are examined, as are the various countermeasures and techniques that have been developed over the years to protect pilots from the potentially adverse consequences of high G flight, such as the G-suit and positive pressure breathing. The accumulated knowledge of human exposure to high G is drawn together within High G Flight, resulting in a definitive volume on the physiological effects of high G and their countermeasures.

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As a response to real or imagined subordination, popular culture reflects the everyday experience of ordinary people and has the capacity to subvert the hegemonic order. Drawing on central theoretical approaches in the field of critical disability studies, this book examines disability across a number of internationally recognised texts and objects from popular culture, including film, television, magazines and advertising campaigns, children’s toys, music videos, sport and online spaces, to attend to the social and cultural construction of disability. While acknowledging that disability features in popular culture in ways that reinforce stereotypes and stigmatise, Disability and Popular Culture celebrates and complicates the increasing visibility of disability in popular culture, showing how popular culture can focus passion, create community and express defiance in the context of disability and social change. Covering a broad range of concerns that lie at the intersection of disability and cultural studies, including media representation, identity, the beauty myth, aesthetics, ableism, new media and sport, this book will appeal to scholars and students interested in the critical analysis of popular culture, across disciplines such as disability studies, sociology and cultural and media studies.

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This volume brings together a selection of the most important published research articles from the ongoing debate about the moral rights of prisoners. The articles consider the moral underpinnings of the debate and include framework discussions for a theory of prisoners’ rights as well as several international documents which detail the rights of prisoners, including women prisoners. Finally, detailed analysis of the moral bases for particular rights relating to prison conditions covers areas such as: health, solitary confinement, recreation, work, religious observance, library access, the use of prisoners in research and the disenfranchisement of prisoners.

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Cytochromes are proteins that catalyze electron transfer reactions of well-known metabolic pathways and are classified in various superfamilies. The CYP, or P450, superfamily accounts for 90% of the oxidative metabolism of clinical drugs. One member of this superfamily, P450 2D6 (or CYP2D6), singlehandedly metabolizes about 25% of all medications in the human liver. Cytochrome P450 2D6: Structure, Function, Regulation, and Polymorphism reviews the current knowledge of CYP2D6 as well as the maturing body of evidence indicating its significance to clinical and pharmacological researchers and practitioners.This book focuses on the critical role CYP2D6 plays in the human liver. It examines the genetic, epigenetic, physiological, pathological, and structural factors of the gene that govern the highly variable metabolism of a number of drugs in clinical use. It highlights the impact of the functional roles of CYP2D6 on clinical practice and drug development and also discusses implications for precise medicine, strategies to avoid adverse drug reactions, and paths for future research.Cytochrome P450 2D6 is a unique, valuable book focusing on a single but immensely powerful human gene. It provides the first single source of comprehensive information on CYP2D6 that serves as an important reference for medical, biomedical, pharmaceutical, and nursing researchers, practitioners, and students.

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Over time, overemphasis and adherence to the same proven routines that helped your organization achieve success can also lead to its decline resulting from organizational inertia, complacency, and inflexibility. Drawing lessons from one of the best models of success, the evolutionary model, Inverting the Paradox of Excellence explains why your organization must proactively seek out changes or variations on a continuous basis for ensuring excellence by testing out a continuum of opportunities and advantages. In other words, to maintain excellence, the company must be in a constant state of flux!The book introduces the patterns and anti-patterns of excellence and includes detailed case studies based on different dimensions of variations, including shared values variations, structure variations, and staff variations. It presents these case studies through the prism of the "variations" idea to help you visualize the difference of the "case history" approach presented here. The case studies illustrate the different dimensions of business variations available to help your organization in its quest towards achieving and sustaining excellence. The book extends a set of variations inspired by the pioneering McKinsey 7S model, namely shared values, strategy, structure, stuff, style, staff, skills, systems, and sequence. It includes case history segments for Toyota, Acer, eBay, ABB, Cisco, Blackberry, Tata, Samsung, Volvo, Charles Schwab, McDonald's, Scania, Starbucks, Google, Disney, and NUMMI. It also includes detailed case histories of GE, IBM, and UPS.

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Most biometric books are either extraordinarily technical for technophiles or extremely elementary for the lay person. Striking a balance between the two, Biometric Technology: Authentication, Biocryptography, and Cloud-Based Architecture is ideal for business, IT, or security managers that are faced with the task of making purchasing, migration, or adoption decisions. It brings biometrics down to an understandable level, so that you can immediately begin to implement the concepts discussed.Exploring the technological and social implications of widespread biometric use, the book considers the science and technology behind biometrics as well as how it can be made more affordable for small and medium-sized business. It also presents the results of recent research on how the principles of cryptography can make biometrics more secure. Covering biometric technologies in the cloud, including security and privacy concerns, the book includes a chapter that serves as a "how-to manual" on procuring and deploying any type of biometric system. It also includes specific examples and case studies of actual biometric deployments of localized and national implementations in the U.S. and other countries.The book provides readers with a technical background on the various biometric technologies and how they work. Examining optimal application in various settings and their respective strengths and weaknesses, it considers ease of use, false positives and negatives, and privacy and security issues. It also covers emerging applications such as biocryptography.Although the text can be understood by just about anybody, it is an ideal resource for corporate-level executives who are considering implementing biometric technologies in their organizations.

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Catalysis plays a vital role in chemical, petroleum, agriculture, polymer, electronics, pharmaceutical, and other industries. Over 90 percent of chemicals originate from catalytic processes. Toughening economic and environmental constraints have proven to be a challenge for meeting the demand of novel efficient and sustainable regio- and stereoselective catalyst systems. Environmentally Sustainable Catalytic Asymmetric Oxidations provides a comprehensive overview of existing ecologically friendly catalyst systems for various asymmetric oxidation processes.Topics include: A survey of existing transition metal-based catalyst systems for asymmetric epoxidations (AEs) with O2 and H2O2 Asymmetric sulfoxidations with H2O2 on chiral metal complexes An overview of various transition metal-catalyzed oxidative transformations with H2O2 or O2 used as the terminal oxidant Organocatalytic asymmetric oxidations Catalytic processes of stereospecific oxidations of C-H functional groups The role that oxoiron(V) intermediates play in chemo- and stereoselective oxidations catalyzed by non-heme iron complexes The book concludes with a discussion of the opportunities and problems associated with the industrial application of stereoselective processes of catalytic oxidation with H2O2 and O2. It also provides examples of processes with industrial potential.Some of the catalysts presented in this book may serve as promising alternatives for existing catalysts—progressively replacing them in manufacturing processes and ultimately making the chemical industry greener and cleaner.

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Nanoscale techniques and devices have had an explosive influence on research in life sciences and bioengineering. Reflecting this influence, Nanopatterning and Nanoscale Devices for Biological Applications provides valuable insight into the latest developments in nanoscale technologies for the study of biological systems. Written and edited by experts in the field, this first-of-its-kind collection of topics: Covers device fabrication methods targeting the substrate on the nanoscale through surface modification Explores the generation of nanostructured biointerfaces and bioelectronics elements Examines microfluidically generated droplets as reactors enabling nanoscale sample preparation and analysis Gives an overview of key biosensors and integrated devices with nanoscale functionalities Discusses the biological applications of nanoscale devices, including a review of nanotechnology in tissue engineering Readers gain a deep understanding of the cutting-edge applications of nanotechnologies in biological engineering, and learn how to apply the relevant scientific concepts to their own research. Nanopatterning and Nanoscale Devices for Biological Applications is the definitive reference for researchers in engineering, biology, and biomedicine, and for anyone exploring the newest trends in this innovative field.

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Engineering Solutions to America’s Healthcare Challenges covers the technologies, systems, and processes that are emerging in hospitals, clinics, community centers, universities, and the White House to repair healthcare in the United States. Focusing on the importance of individuals being proactive about their own state of health, it presents a systems approach to changing the way healthcare professionals do business and take care of their patients. Written by a leading government and private sector consultant with more than a decade of experience as an industrial engineer, the book features interviews with leading industry experts, both domestic and international. Describing how industrial engineering practices are shaping healthcare, it explains why systems thinking must be the foundation for every aspect of healthcare.The book presents proven Lean and Six Sigma tools that can help any healthcare organization begin making operational improvements that result in a better quality of care for patients—all while reducing and even eliminating the waste of time, money, and human resources. These solutions include implementing Six Sigma in emergency rooms, 5S in accounting for medical inventory, using Theory of Constraints to form a plan for shortening the length of stay in hospitals, how informatics are used to aggregate and benchmark sensitive data, and design of experiments to recruit and retain the best healthcare talent. The book illustrates the most common factors involved with successful Six Sigma projects in healthcare organizations and considers the implications of a rapidly growing medical tourism industry. It addresses the role of insurance on healthcare improvement and also previews some of the most fascinating technological advances currently in development. It also offers examples and analysis of The Institute of Medicine's six aims for healthcare: safety, effectiveness, efficiency, timeliness, family-centered focus, and equity.

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In Crime Prevention: Theory and Practice, Second Edition, Dr. Schneider has updated every chapter in this reliable text using the latest research, the most recently published articles and books, and feedback from professors and students using the first edition. Providing an introduction to dominant approaches, key concepts, theories, and research, the book supplies concrete advice on planning, implementing, and evaluating a crime prevention plan. This edition includes a new chapter applying crime prevention through social development principles to adolescents and young adults. This chapter is a recognition of the disproportionate rate of offending by adolescents and young adults as well as the distinctive risk factors faced by these groups. It also emphasizes the unique nature of applying social problem-solving solutions to adolescents and young adults who have been in formal contact with the criminal justice system. The focus is on recidivism prevention, an often-ignored, but critical aspect of crime prevention. Laying out a systematic blueprint for a successful crime prevention project, the book also updates the extant literature on crime prevention—in particular the addition of research that has been published since the first edition of this book. Updated case studies reflecting new data present real examples of crime prevention programs and organizations and illustrate the conceptual, theoretical, and empirical elements of the book. Learning objectives, discussion questions, and exercises facilitate learning and retention and a companion website provides ancillary material for students and professors.

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The unprecedented potential of nanotechnology for early detection, diagnosis, and personalized treatment of diseases has found application in every biomedical imaging modality. However, with the increasing concern about the ethical and toxicity issues associated with some "nanoplatforms," biomedical researchers are in pursuit of safer, more precise, and effective ways to practice nanomedicine. Designed and written to be accessible to anyone, with or without previous knowledge of nanotechnology, Nanomedicine: A Soft Matter Perspective takes a balanced look at potential pitfalls and challenges faced by the field and how they can be translated into nonomedicine technologies.A multidisciplinary and fast-evolving research area, nanomedicine presents new clinically relevant promises grounded in the disciplines of molecular biology, genomics, chemistry, and nanotechnology. Nanoparticle-based theranostic approaches have emerged as an interdisciplinary area, which shows promise to understand the components, processes, dynamics, and therapies of a disease at a molecular level. This book discusses some of the unique opportunities presented by biomaterials at the nanoscale. The book provides a broad introduction to the areas of nanomedicinal application with an emphasis on imaging and therapeutics. It covers "soft" nanoscopic objects with prerequisite features for different imaging modalities with a potential for image-guided drug delivery. The book also offers a general introduction to the various drug delivery systems and their opportunities from chemistry, materials, biology, and nanomedical standpoints. The chapters provide a comprehensive introduction to the field and the subfield, with a deeper discussion on the individual modalities for molecular imaging and their present status of clinical translation.

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Where end-users once queued up to ask the IT department for permission to buy a new computer or a new version of software, they are now bypassing IT altogether and buying it on their own. From laptops and smartphones to iPads and virtually unlimited software apps, end-users have tasted their freedom and love it. IT will simply never be the same.Bring Your Own Devices (BYOD) Survival Guide explains the psycho-techno phenomenon also known as bring your own technology (BYOT). Providing the guidance necessary for living in this new world, it describes the new end-users (Millennials) and their demands, as well as the strategic and tactical ramifications of these demands.Examining the business aspects of BYOD—selection, purchasing, and corporate culture—the book covers the broad range of technical considerations including selection, connectivity, training, support, and security. It also includes an extensive set of best practices.The book is geared for the small- to medium-size enterprise that needs to integrate BYOD into their environment. It addresses topics such as content and data management, risk assessment, performance measurement, management, and even configuration management.The text includes a set of Quick Start guides that provide tips for such things as assessing costs, cloud integration, and even legal issues. There is also a full set of appendices that supply helpful information on everything from security settings for Apple iOS devices to a sample employee mobile device agreement.

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Security sensitive microbes (viruses, bacteria, fungi, and parasites) and toxins, which are often referred to as the select agents and toxins, have the capacity to cause serious illness and death in humans, animals, and plants. Throughout history, these microbes and toxins have been exploited in one form or another as biowarfare and bioterror agents that create fear and panic well beyond any actual physical damages they might cause.Manual of Security Sensitive Microbes and Toxins provides comprehensive, state-of-the-art coverage of microbes and toxins of biosecurity concern. The ultimate goal is to increase our awareness of these agents and enhance our preparedness against any future bio-emergencies.The book begins with an introduction containing a brief overview of the historical aspects of security sensitive microbes and toxins. This is followed by a concise summary of the current status in relation to the regulation of security sensitive microbes and toxins and a discussion of future development trends.The book is divided into seven parts: Microbes and Toxins Affecting Humans and Animals: Viruses Microbes and Toxins Affecting Human and Animals: Bacteria Microbes and Toxins Affecting Human and Animals: Fungus and Parasite Microbes and Toxins Affecting Human and Animals: Toxins Microbes Affecting Animals: Viruses Microbes Affecting Animals: Bacteria Microbes Affecting Plants Written by experts in the relevant areas of research, the chapters are authoritative reviews, each one covering a single microbe or toxin with respect to its classification, biology, epidemiology, pathogenesis, identification, diagnosis, treatment, and prevention. The chapters also discuss the limitations of our current knowledge and challenges relating to improved detection and control of the microbe or toxin.

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This genuinely pocket-sized guide to being on call is ideal for medical students and newly qualified junior doctors seeking a convenient and concise handbook to refer to in busy clinical settings. Clear, concise and systematic, Pocket on Call contains exactly what you need to make rapid and appropriate decisions without overwhelming or extraneous information.With this book in your pocket, you’ll be equipped to tackle being on call appropriately and with confidence. Answering the questions that are not always addressed in the lecture theatre, with this book as an indispensable companion the inexperienced doctor will be equipped to tackle being on call appropriately and with confidence.

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This essential text provides a readable yet sophisticated overview of the basic concepts of information technologies as they apply in healthcare. Spanning areas as diverse as the electronic medical record, searching, protocols, and communications as well as the Internet, Enrico Coiera has succeeded in making this vast and complex area accessible and understandable to the non-specialist, while providing everything that students of medical informatics need to know to accompany their course. Fully revised, the third edition of Guide to Health Informatics remains essential reading for all health science undergraduates, clinical health professionals, and health service managers who need to appreciate and understand the role of informatics and its associated technologies for optimal practice and service delivery.

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Following on from the highly successful first edition, published in 2006, the second edition of Basic Orthopaedic Sciences has been fully updated and revised, with every chapter rewritten to reflect the latest research and practice. The book encompasses all aspects of musculoskeletal basic sciences that are relevant to the practice of orthopaedics and that are featured and assessed in higher specialty exams. While its emphasis is on revision, the book contains enough information to serve as a concise textbook, making it an invaluable guide for all trainees in orthopaedics and trauma preparing for the FRCS (Tr & Orth) as well as for surgeons at MRCS level, and other clinicians seeking an authoritative guide.The book helps the reader understand the science that underpins the clinical practice of orthopaedics, an often neglected area in orthopaedic training, achieving a balance between readability and comprehensive detail. Topics covered include biomechanics, biomaterials, cell & microbiology, histology, structure & function, immunology, pharmacology, statistics, physics of imaging techniques, and kinesiology.

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The Handbook of Clinical Anaesthesia has been completely updated for this new edition, providing trainee anaesthetists with a concise but comprehensive source of clinical information, and qualified anaesthetists with an indispensable aide. Written and edited by experts in the field, this compact but detailed text provides all the essential practical knowledge required by anaesthetists on co-existing medical conditions, operative procedures, and techniques. The handbook is presented in Parts 1 to 3. The first part covers Patient Conditions; the second part Surgical Procedures; and the third part Anaesthetic Factors. Each part is subdivided into sections on each organ system, and each section is divided into chapters. These chapters are in alphabetical order, and cover all common and rare conditions that anaesthetists will encounter within their practice.Trainees will find this book to be an excellent general guide, but in particular a provider of reliable information in preparation for examination as well as teaching clinical technique and practice.

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With an estimated 3.3 billion ionizing radiation imaging examinations performed worldwide each year, the growing use of x-ray-based diagnostic procedures raises concerns about long-term health risks, especially cancer. In addition, rapid growth in the number of nuclear power plants around the world increases the risk of a nuclear accident similar to that of Fukushima, Japan. Add to this, exposure to non-ionizing radiation from prolonged cell phone use, proton radiation from solar flares, and potential nuclear conflict or a dirty bomb attack, and the need to expand our repertoire of radiation prevention and mitigation strategies becomes increasingly urgent. Radiation Injury Prevention and Mitigation in Humans identifies and examines physical protection strategies as well as non-toxic, cost-effective biological protection strategies. This includes agents that—when administered orally before and/or after irradiation exposures—could be effective in preventing and mitigating acute radiation damage. The book discusses implementing physical and biological protection strategies particularly for first responders, radiation workers, astronauts, and civilians who might be exposed to higher doses of radiation in the course of their activities. The book describes: Physics of ionizing radiation and radiological weapons, principles of nuclear reactors, the types of radiological weapons, and consequences of their explosions Acute and late health effects of high and low doses of radiation The efficacy of FDA-approved and unapproved radioprotective and radiation mitigating agents The efficacy of radioprotective and radiation mitigating agents not requiring FDA approval (antioxidants and herbs) Scientific data and rationale in support of using micronutrient preparations containing dietary and endogenous antioxidants for preventing acute radiation sickness and for mitigating the late adverse health effects among survivors of high and low doses of radiation Examining cutting-edge advances in the research of the effects of non-ionizing radiation on cellular and genetic levels, the book proposes an implementation plan of both physical and biological protection strategies. It covers the full range of potential sources of radiation and includes an up-to-date list of helpful resources and references for the latest research and readings on the topic.

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The Book provides knowledge on the diversity of disease causing microbes including bacteria, viruses, fungi and Protozoans- the major diseases they cause and the environmental factors that influence the occurrence, transmission and spread of microbes along with the epidemiological factors determining the occurrence of disease.

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An Illustrated Introduction to Topology and Homotopy explores the beauty of topology and homotopy theory in a direct and engaging manner while illustrating the power of the theory through many, often surprising, applications. This self-contained book takes a visual and rigorous approach that incorporates both extensive illustrations and full proofs.The first part of the text covers basic topology, ranging from metric spaces and the axioms of topology through subspaces, product spaces, connectedness, compactness, and separation axioms to Urysohn’s lemma, Tietze’s theorems, and Stone-Čech compactification. Focusing on homotopy, the second part starts with the notions of ambient isotopy, homotopy, and the fundamental group. The book then covers basic combinatorial group theory, the Seifert-van Kampen theorem, knots, and low-dimensional manifolds. The last three chapters discuss the theory of covering spaces, the Borsuk-Ulam theorem, and applications in group theory, including various subgroup theorems.Requiring only some familiarity with group theory, the text includes a large number of figures as well as various examples that show how the theory can be applied. Each section starts with brief historical notes that trace the growth of the subject and ends with a set of exercises.

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Applicable to any problem that requires a finite number of solutions, finite state-based models (also called finite state machines or finite state automata) have found wide use in various areas of computer science and engineering. Handbook of Finite State Based Models and Applications provides a complete collection of introductory materials on finite state theories, algorithms, and the latest domain applications. For beginners, the book is a handy reference for quickly looking up model details. For more experienced researchers, it is suitable as a source of in-depth study in this area. The book first introduces the fundamentals of automata theory, including regular expressions, as well as widely used automata, such as transducers, tree automata, quantum automata, and timed automata. It then presents algorithms for the minimization and incremental construction of finite automata and describes Esterel, an automata-based synchronous programming language for embedded system software development.Moving on to applications, the book explores regular path queries on graph-structured data, timed automata in model checking security protocols, pattern matching, compiler design, and XML processing. It also covers other finite state-based modeling approaches and applications, including Petri nets, statecharts, temporal logic, and UML state machine diagrams.

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Until the late 20th century, computational studies of biomolecules and nanomaterials had considered the two subjects separately. A thorough presentation of state-of-the-art simulations for studying the nanoscale behavior of materials, Simulations in Nanobiotechnology discusses computational simulations of biomolecules and nanomaterials together. The book gives readers insight into not only the fundamentals of simulation-based characterizations in nanobiotechnology, but also in how to approach new and interesting problems in nanobiotechnology using basic theoretical and computational frameworks. Presenting the simulation-based nanoscale characterizations in biological science, Part 1: Describes recent efforts in MD simulation-based characterization and CG modeling of DNA and protein transport dynamics in the nanopore and nanochannel Presents recent advances made in continuum mechanics-based modeling of membrane proteins Summarizes theoretical frameworks along with atomistic simulations in single-molecule mechanics Provides the computational simulation-based mechanical characterization of protein materials Discussing advances in modeling techniques and their applications, Part 2: Describes advances in nature-inspired material design; atomistic simulation-based characterization of nanoparticles’ optical properties; and nanoparticle-based applications in therapeutics Overviews of the recent advances made in experiment and simulation-based characterizations of nanoscale adhesive properties Suggests theoretical frameworks with experimental efforts in the development of nanoresonators for future nanoscale device designs Delineates advances in theoretical and computational methods for understanding the mechanical behavior of a graphene monolayer The development of experimental apparatuses has paved the way to observing physics at the nanoscale and opened a new avenue in the fundamental understanding of the physics of various objects such as biological materials and nanomaterials. With expert contributors from around the world, this book addresses topics such as the molecular dynamics of protein translocation, coarse-grained modeling of CNT-DNA interactions, multi-scale modeling of nanowire resonator sensors, and the molecular dynamics simulation of protein mechanics. It demonstrates the broad application of models and simulations that require the use of principles from multiple academic disciplines.

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Although the genomic era is no longer in its infancy, the life sciences are still facing questions about the role of endogenous proteins and peptides in homeostasis and pathologies. Delving into one of the most current fields of interest in biology and medicine, Neuropeptides in Neuroprotection and Neuroregeneration describes the impact of neuropeptides on neuroprotection and neuroregeneration. The book begins with chapters describing important features of the endogenous neuropeptide systems related to their formation, receptor signaling, and inactivation. It includes chapters focused on the design and development of peptide-like drugs (peptidomimetics). In addition, the book covers: General aspects regarding the biosynthesis, structures, and distribution of neuroactive peptides and their receptors Basic mechanisms for neuropeptide action, metabolism, as well as techniques for their detection and aspects essential for the cellular mechanisms underlying brain pathology Neuropeptides known for their impact in neurodegenerative and neuroprotective processes Fundamental aspects as well as recent progress in the development of peptidomimetics of neuroprotective and cognition-enhancing peptides

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The Algebra of Organic Synthesis combines the aims, philosophies, and efforts involved in organic synthesis, reaction optimization, and green chemistry with techniques for determining quantitatively just how "green" synthesis plans are. It provides the first complete quantitative description of synthesis strategy analysis in the context of green chemistry and reaction optimization. Providing what is perhaps the first complete description of synthesis strategy analysis, this book: Explores quantitative material efficiency for synthesizing molecules, including 1,000+ worked out synthesis plans to important target molecules Explains, in simple language, the most useful ideas in graph theory that have direct application in organic synthesis Reinforces the value of simple mathematical analysis in organic synthesis to help any synthetics or process chemist understand presented ideas and apply them to their own work Illustrates concepts with example target plans to classical targets that are considered milestones in synthetic chemistry, from pharmaceuticals, industrial commodity chemicals, dyestuffs, agrichemicals, flavorings, natural products, and molecules of theoretical interest The accompanying additional resources include a reproduction of the tables in the book, with direct electronic links to files for all plans. Files contain a list of references for each plan, including secondary references for the synthesis of starting materials if applicable. Ancillary materials also include a complete synthesis scheme with fully balanced chemical equations, a synthesis tree, a summary of green metrics parameters, a target bond map and list of reagents that end up in the target molecule, and a series of graphs that offer a visual depiction of the plan performance.

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Always interesting and informed, national award-winning journalist Mark Hagland demonstrates how pioneering organizations are combining new tools with a new way of thinking to reinvent the way we deliver health care services in this country. Through exceptionally well-documented case studies, this insightful volume — Puts the current journey towards industry-wide quality transformation into an understandable context for executive, board, and policymaking audiences Explores how performance improvement methodologies borrowed from other industries, including Six Sigma, Lean management, and the Toyota Production System are transforming care delivery processes and administrative operations nationwide Examines the strategic role that information technology will play in the transformation of clinical care quality and patient safety The case studies contained in this book document the surprising strides being made by pioneering hospitals and health systems, advances that have the potential to transform the delivery of health care in the United States. Offered in a context that frames the current state of health care quality in this country, they are indispensable reading for anyone working in the trenches to improve that quality.

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While the science of yogurt is nearly as old as the origin of mankind, there have been rapid changes in yogurt development since the turn of the 19th century, fueled by continuing developments in biological sciences. Development and Manufacture of Yogurt and Other Functional Dairy Products presents a comprehensive review of all aspects of yogurt and other fermented dairy foods, including production, processing, preparation, regulations, and health aspects.Condensing more than 12,000 pages of recently published literature, expert contributors, including several clinicians, address the most recent developments in probiotics and the interaction between yogurt and immunological and intestinal bowel diseases. They explain how beneficial and harmful bacteria are colonized in the human intestinal system and how those bacteria can either strengthen or weaken immunological functions. This resource also explores the little-known varieties of functional dairy products – such as ayran, kefir, koumiss, cacik, and tarator – that are currently only consumed in small parts of the world but that are likely to reach supermarkets worldwide in the not-so-distant future. Development and Manufacture of Yogurt and Other Functional Dairy Products presents the most recent developments in biosciences and their applications in yogurt-human health interactions. The depth and breadth of coverage make this book an indispensable reference for those involved with the research and manufacturing of milk and dairy products.

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Starch is one of the major polysaccharides employed as biopolymers by the food industry, and its wide range of applications has resulted in intense research of starch structure and technology. Written by an outstanding multidisciplinary team with complementary expertise in both academia and industry, Starches: Characterization, Properties, and Applications takes an innovative approach to the trends of starch production.The book provides an up-to-date overview of starch applications in the food, textiles, pharmaceuticals, chemical, agricultural, and plastic industries when used as a substitute for synthetic polymers. Starch nanocomposites properties and starch-based blends biodegradability are also discussed. The book covers the recent advances made in starch characterization using techniques such as atomic force microscopy and nuclear magnetic resonance. It discusses the main modified starches applications and enzymes used on starch industry. It also addresses starch characterization at the granular, macromolecular, and rheological levels. Under the editorial guidance of renowned food scientist, Andréa Curiacos Bertolini, this book to address starch characterization, applications and biodegradation of starch blends, making it an ideal resource for researchers and product developers interested in starch characterization, nanocomposites, and biopolymer degradation.

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Explore Historic Bridge Design through the Perspective of Modern EngineeringHistoric Bridges:Evaluation, Preservation, and Management provides both an admiring and a technical account of bridge engineering through an exploration of several remarkable examples. From ancient China to modern-day Minnesota, the book discusses the history and structural evaluation of bridges, as well as their preservation, and restoration. With chapters written by renowned engineers, this unique resource — Compares the techniques and materials used in building three railroad bridges that traversed the Mississippi at the same site in 1865, 1887, and 1910 Investigates a legendary stone-arch bridge constructed in Ancient China in 606 A.D. Demonstrates how historians and engineers in Milwaukee found an approach to new bridge design that balances modern design standards with aesthetic interpretation Details a collaborative team approach to historic bridge management in Minnesota Considers the design and repair process of rapidly disappearing wrought iron bridges Discusses preservation of stone masonry aqueducts on the Chesapeake and Ohio CanalAn educational treatise for engineers and historical preservationists, this work includes a wealth of illustrations and scientific tables. Demonstrating historic engineering significance beyond their utilitarian function, the bridges encountered in these pages are true landmarks, as worthy of emulation as they are preservation.

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Designed specifically for students of economics, business economics, and allied areas at the undergraduate and postgraduate level, this book includes specially contributed articles by acknowledged experts of the discipline from all over the world. It covers critical areas like theory of externalities and market failure, valuation and accounting of environmental impacts, economic instruments for industrial pollution and environmental resources, poverty and environmental degradation, and corporate environmental management. The book also explores how to make development more sustainable, micro economics for ecological sustainability, and environmental policy in open economies.

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Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology experimentation in mice but, more importantly, a "how to interpret" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity. The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit: baseline anatomic and physiologic traits of developing mice principles of good experimental design and statistical analysis for mouse developmental pathology studies procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, suing conventional autopsy-based or novel non-invasive imaging techniques; methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids; options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., "lesions") during development; and well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta).

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Presenting state-of-the-art research advancements, Porous Media: Applications in Biological Systems and Biotechnology explores innovative approaches to effectively apply existing porous media technologies to biomedical applications. In each peer-reviewed chapter, world-class scientists and engineers collaborate to address significant problems and discuss exciting research in biological systems.The book begins with discussions on bioheat transfer equations for blood flows and surrounding biological tissue, the concept of electroporation, hydrodynamic modeling of tissue-engineered material, and the resistance of microbial biofilms to common modalities of antibiotic treatments. It examines how biofilms influence porous media hydrodynamics, describes the modeling of flow changes in cerebral aneurysms, and highlights recent advances in Lagrangian particles methods. The text also covers passive mass transport processes in cellular membranes and their biophysical implications, the modeling and treatment of mass transport through skin, the use of porous media in marine microbiology, the transport of large biological molecules in deforming tissues, and applications of magnetic stabilized beds for protein purification and adsorption, antibody removal, and more. The final chapters present potential in situ characterization techniques for studying porous media and conductive membranes and explain the development of bioconvection patterns generated by populations of gravitactic microorganisms in porous media.Using a common nomenclature throughout and with contributions from top experts, this cohesive book illustrates the role of porous media in addressing some of the most challenging issues in biomedical engineering and biotechnology. The book contains sophisticated porous media models that can be used to improve the accuracy of modeling a variety of biological processes.

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Finding detailed information on WiMAX, from fundamentals to future directions, is challenging at best. While almost everyone engaged in wireless communications, whether they are academics or professionals, has accumulated a variety of information on WiMAX over time, a comprehensive, single-source would be invaluable to have. The WiMAX Handbook is that resource, presenting what you need to know about this innovative technology.

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Despite a growing literature debating the consequences of neo-liberal political and economic policy in the former Eastern bloc, the idea of neo-liberal personhood has so far received limited attention from scholars of the region. Presenting a range of ethnographic studies, this book lays the groundwork for a new disciplinary agenda by critically examining novel technologies of self-government which have appeared in the wake of political and economic liberalization. Neoliberalism, Personhood, and Postsocialism explores the formation of subjectivities in newly marketized or marketizing societies across the former Eastern Bloc, documenting the rise of the neo-liberal discourse of the ’enterprising’ self in government policy, corporate management and education, as well as examining the shifts in forms of capital amongst marginal capitalists and entrepreneurs working in the grey zone between the formal and informal economies. A rich investigation of the tools of neo-liberal governance and the responses of entrepreneurs and families in changing societies, this book reveals the full complexity of the relationship between historically and socially embedded economic practices, and the increasing influence of libertarian political and economic thought on public policy, institutional reform, and civil society initiatives. As such, it will appeal to anthropologists, sociologists and geographers with interests in political discourse, identity, entrepreneurship and organizations in post-socialist societies.

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In 1853 Robert Schumann identified fully-formed compositional mastery in the young Brahms, who nevertheless in the years following embarked on a period of intensive further study, producing, among other works, the neo-baroque Sarabande and Gavotte. These dances have not been properly recognized as constituting a distinct Brahms work before now, but manuscript evidence and their performance history indicate that Brahms and his friends thought of them as such in the mid-1850s, when they became the first music of his performed publicly in Gdansk, Vienna, Budapest and London. He later suppressed the dances, using them instead as a thematic quarry for three chamber music masterpieces, from different stages in his life and in distinctly different ways: the Second String Sextet, the First String Quintet and the Clarinet Quintet. This book gives an account of the compositional and performance history, stylistic features and re-uses of the dances, setting these in the wider context of Brahms’s developing creative concerns and trajectory. It constitutes therefore a study of a ’lost’ work, of how a fully-formed master opens himself to ’the in-flowing from afar’ (in Martin Heidegger’s terms), and of the transformative reach and concomitant expressive richness of Brahms’s creative thought.

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This student-friendly textbook offers a comprehensive introduction to globalization studies and the European Union within a multipolar world. It provides its readers with critical analysis of the key concepts of multilateral global and regional governance and Europe’s role in the world; and this in an accessible and intelligible fashion. This volume collects contributions by eminent scholars from world class universities from five different continents. As such, this unique exercise in transnational multi-disciplinary cooperation, provides extensive coverage of the main issues pertaining to multilateral cooperation - notably its history, troubles, legitimacy challenges and efficiency questions - from a variety of national perspectives. The book covers the major issues confronting students of European and global studies, amongst which: pressing security challenges, new forms of institutionalized cooperation, shifting international trade flows, the notion of responsibility to protect, social imbalances and environmental emergencies, the need for less contingent forms of legitimacy for global regulation, as well as global public opinion and transnational civil society networks. Each chapter includes a summary of its salient points; methodological indications; illuminating illustrations; and a suggested list for further reading. This textbook strives to help students develop a better and more secure grasp of the innovative balance between interdisciplinary openness and disciplinary rigor when engaging with global governance studies, comparative regionalism, normative studies, international political economy or international law.

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The last fifty years have seen a notable expansion of philosophical scrutiny of the fundamental concepts and structures of Anglo-American criminal law and this volume offers a selection from journal articles and book chapters of significant and influential work in this field. Taken together, these essays illustrate how contemporary philosophical reflection on criminal law has broadened its focus beyond the longstanding and still active debate over the moral legitimacy of punishment. In addition to punishment, the subjects also covered in this collection range from excuse and justification defenses and the conundrums of attempt liability to the bases of culpability and criminal responsibility and the appropriate limits of the criminal law. The introduction clarifies the contexts in which these subjects are discussed, and the volume includes an extensive bibliography.

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As most jurisdictions move away from the death penalty, some remain strongly committed to it, while others hold on to it but use it sparingly. This volume seeks to understand why, by examining the death penalty’s relationship to state governance in the past and present. It also examines how international, transnational and national forces intersect in order to understand the possibilities of future death penalty abolition. The chapters cover the USA - the only western democracy that still uses the death penalty - and Asia - the site of some 90 per cent of all executions. Also included are discussions of the death penalty in Islam and its practice in selected Muslim majority countries. There is also a comparative chapter departing from the response to the mass killings in Norway in 2011. Leading experts in law, criminology and human rights combine theory and empirical research to further our understanding of the relationships between ways of governance, the role of leadership and the death penalty practices. This book questions whether the death penalty in and of itself is a hazard to a sustainable development of criminal justice. It is an invaluable resource for all those researching and campaigning for the global abolition of capital punishment.

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Taking cross-disciplinary and comparative approaches to the volume’s subject, this exciting collection of essays offers a reassessment of Shakespeare’s erotic and Ovidian mythology within classical and continental aesthetic contexts. Through extensive examination of mythological visual and textual material, scholars explore the transmission and reinvention of Ovidian eroticism in Shakespeare’s plays to show how early modern artists and audiences collectively engaged in redefining ways of thinking pleasure. Within the collection’s broad-ranging investigation of erotic mythology in Renaissance culture, each chapter analyses specific instances of textual and pictorial transmission, reception, and adaptation. Through various critical strategies, contributors trace Shakespeare’s use of erotic material to map out the politics and aesthetics of pleasure, unravelling the ways in which mythology informs artistic creation. Received acceptions of neo-platonic love and the Petrarchan tensions of unattainable love are revisited, with a focus on parodic and darker strains of erotic desire, such as Priapic and Dionysian energies, lustful fantasy and violent eros. The dynamics of interacting tales is explored through their structural ability to adapt to the stage. Myth in Renaissance culture ultimately emerges not merely as near-inexhaustible source material for the Elizabethan and Jacobean arts, but as a creative process in and of itself.

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Deterrence is a theory which claims that punishment is justified through preventing future crimes, and is one of the oldest and most powerful theories about punishment. The argument that punishment ought to secure crime reduction occupies a central place in criminal justice policy and is the site for much debate. Should the state deter offenders through the threat of punishment? What available evidence is there about the effectiveness of deterrence? Is deterrence even possible? This volume brings together the leading work on deterrence from the dominant international figures in the field. Deterrence is examined from various critical perspectives, including its diversity, relation with desert, the relation of deterrence with incapacitation and prevention, the role deterrence has played in debates over the death penalty, and deterrence and corporate crime.

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Tackling juvenile offending has become a key part of crime reduction strategies. The articles selected for this volume examine juvenile offending from various critical perspectives and represent the work of the most influential international figures in the field. The issues addressed include: the different needs and perspectives of youth offenders; whether offenders should be treated differently from others because of their age; recommendations of policy changes; identification of risk factors; issues surrounding the sentencing of juvenile offenders; and the relevance of restorative justice.

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The essays selected for this volume focus on issues that arise when attempting to design, review and undertake research involving human participants who are experiencing a private or public emergency. The main themes discussed by the essays are: the distinctive and significant ethical questions as to how research participants can be treated during emergency settings; the ethical challenges raised by emergencies for researchers undertaking research and its effects on the nature of research pursued; and procedural obstacles raised by emergencies which can affect the quality of good research ethics review. The volume is unique in that it is the first collection to exclusively deal with all of the central ethical aspects of conducting human subject research in the context of emergency.

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The essays selected for this volume address topics at the intersection of religion and equality law, including discrimination against religion, discrimination by religious actors and discrimination in favor of religious groups and traditions. The introduction provides a conceptual guide to these types of inequality - which are often misunderstood or conflated - and it offers an analysis of different species of discrimination within each broad category. Each section of the volume contains both theoretical essays, which set out frameworks for thinking about the relevant type of inequality, and essays that examine real-world disputes. For example, the articles address the conflicts over headscarf laws in France and Turkey, the place of so-called traditional religions in Africa, the display of Roman Catholic crucifixes in Italian classrooms, and the ability of American religious organizations to be free of employment laws in their treatment of clergy. This volume brings together classic articles which are otherwise difficult to access, enables students to study key articles side-by-side, and provides instructors with a valuable teaching resource.

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Amongst recent contemporary art and museological publications, there have been relatively few which direct attention to the distinct contributions that twentieth and twenty-first century artists have made to gallery and museum interpretation practices. There are fewer still that recognise the pedagogic potential of interventionist artworks in galleries and museums. This book fills that gap and demonstrates how artists have been making curious but, none-the-less, useful contributions to museum education and curation for some time. Claire Robins investigates in depth the phenomenon of artists' interventions in museums and examines their pedagogic implications. She also brings to light and seeks to resolve many of the contradictions surrounding artists' interventions, where on the one hand contemporary artists have been accused of alienating audiences and, on the other, appear to have played a significant role in orchestrating positive developments to the way that learning is defined and configured in museums. She examines the disruptive and parodic strategies that artists have employed, and argues for that they can be understood as part of a move to re-establish the museum as a discursive forum. This valuable book will be essential reading for students and scholars of museum studies, as well as art and cultural studies.

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This volume collects some of the best recent writings on St. Thomas’s philosophy of law and includes a critical examination of Aquinas’s theory of the relation between law and morality, his natural law theory, as well as the modern reformulation of his approach to natural rights. The volume shows how Aquinas understood the importance of positive law and demonstrates the modern relevance of his writings by including Thomistic critiques of modern jurisprudence and examples of applications of Thomistic jurisprudence to specific modern legal problems such as federalism, environmental policy, abortion and euthanasia. The volume also features an introduction which places Aquinas’s writings in the context of modern jurisprudence as well as an extensive bibliography. The volume is suited to the needs of jurisprudence scholars, teachers and students and is an essential resource for all law libraries.

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Looking past the apparent lack of a sustainable Irish display culture, this book demonstrates that there is a very full story to tell of the way Ireland displayed its art from the late eighteenth to the early twentieth century. Ireland on Show analyzes the impact of the display of art as a significant political and cultural feature in the make-up of nineteenth-century Ireland - and in how Ireland was viewed beyond its own shores, in particular in Great Britain and the United States. Fintan Cullen directs much-needed critical attention and analysis to a subject that has been largely overlooked from an Irish perspective. This study moves beyond museums, to address the range of art institutions in Irish cities that displayed art, from the Royal Hibernian Academy, founded in the 1820s, to Hugh Lane's Municipal Art Gallery, opened in Dublin in 1908. Throughout, the book explores the battle between the display of a unionist ethos and a nationalist point of view, a constant that resurfaces over the period. By highlighting the tension between unionist and nationalist viewpoints, Cullen uses the display of art to investigate the complexities of Irish cultural life before the founding of the Free State.

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Through the analysis of several commemorative acts in space, matter and image, namely museums and memorials, this book reflects on the ways in which architecture as a discipline, a practice and a discourse represents the Holocaust. In doing so, it problematises how one presents an extreme historical case in a contemporary context and integrates the historical into actuality. By examining several cases, the book defines the issues faced by various architects who dealt with this topic and discusses their separate and distinctive approaches. In each case, it analyses the ways in which the cultural and political contexts of commemoration led to a different interpretation of the condition. Focusing on the Ghetto Fighters’ House, the world’s first Holocaust museum; Yad Vashem, Israel’s national Holocaust memorial in Jerusalem; the US Holocaust Memorial Museum in Washington; and the Holocaust Memorial in Berlin, the book discusses how the representation of history by architecture creates a dialectic process in which architecture mediates the past to the present, while at the same time creating a present saturated with historical contexts. It shows how, together, they are incorporated into one another and create a new reality: past and present intertwined.

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