Search results for ""taylor francis inc""

A multibillion dollar industry that has tripled in the last ten years, turfgrass management plays an important role in landscaping, golf courses, and other sports surfaces. Proper management and cultural practices are crucial for the performance of these versatile grasses, creating a demand among scientists, researchers, and industry professionals for better quality, hardier grasses. The mounting collection of research into new species, modern cultivars, and stress tolerant genotypes requires a high-quality, accessible resource. Filling a long-empty niche by compiling the most complete, up-to-date collection of contributions from internationally known specialists, Handbook of Turfgrass Management and Physiology is the only single source reference that covers every aspect of turfgrass maintenance and cultivation. Divided into several sections, this all-inclusive volume begins with an introductory chapter on turf related issues. The second section reveals detailed accounts of turfgrass growth, management, and cultural practices such as carbon metabolism and overseeding. Subsequent sections cover sports turf management and growth regulating factors, as well as breeding, genetics, and biotechnology. The text highlights research in turfgrass pathology and disease including nutritional disorders, rapid blight, and fungal diseases. The book reviews several methods of pest control using herbicides, as well as biological, and microbial control agents. It provides extensive information on the physiological responses of turfgrass to acidic soil, salinized water, temperature, light, depleted oxygen, reactive nitrogen use, and other environmental stressors. The final section looks at future and potential grasses requiring minimal maintenance and management. Offering hundreds of figures and tables, thousands of references, and an extensive index, Handbook of Turfgrass Management and Physiology is the definitive reference to the dynamic and growing world of turfgr

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This comprehensive treatise offers an in-depth discussion of natural toxicants in plants, emphasizing their effects as defenses against herbivory. Coevolution of plants and her-bivores are covered with a detailed treatment of toxicant metabolism and systemic effects in mammalian tissues. Con-sideration of the economic importance of plant toxins, modi-fication by plant breeding, management of toxico-sis, and toxicant problems in various geographic areas are in-cluded. Each volume offers an extensive description of chemistry, biosynthesis, analysis, distribution in plants, metabolism in mam-mals and insects, and practical problems in humans and livestock.

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This book provides an updated overview of eicosanoid metabolism. It also presents a timely discussion of eicosanoid metabolism in the process of tumor cell metastasis, in chemoprotection and radioprotection associated with cancer therapy, and in cell differentiation. The book focuses on the role of eicosanoids in the immunology of malignant disease. This includes how various immune cell populations in cancer are affected by the secretion and action of various eicosanoids and metabolites of eicosanoids and how these processes may be affected by various pharmacological manipulations and interventions to augment anti-tumor immunity. Head and neck cancer is covered in great detail to illustrate a cancer in humans where these considerations are particularly relevant. This important volume demonstrates that the principal factor in cancer patient immunologic deficiency is related to excess secretion by monocytes of prostaglandins.

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The objective of this book is to review and summarize recent developments in our understanding of iron transport and storage in living systems. It includes an overview of the evolutionary aspects of iron metabolism and bacterial iron transport, as well as a detailed discussion of molecules with specific roles in iron metabolism in higher organisms. It also presents relationships between intracellular iron metabolism and cell proliferation. Iron Transport and Storage addresses the comparative aspects of iron transport and storage in different tissues. This essential volume is very useful for hematologists, physical and biological chemists, cell and molecular biologists, physiologists, and clinicians with an interest in the biology and metabolism of iron.

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Due to the extensive use of treated wood products throughout urban and agricultural communities, information concerning the environmental and health risks associated with treated wood is very much in demand. Responding to increasing need for a comprehensive and cohesive source on this topic, Environmental Impacts of Treated Wood compiles the latest information concerning regulations, environmental impact studies, new wood preservative formulations, and state-of-the-art disposal technologies available for minimizing environmental impacts caused by treated wood.Beginning with a background of the production of the most common treated wood products, this book discusses how chemical leaching and transport of certain wood preservatives affect the environment, particularly chromated copper arsenate. A separate section is devoted to case studies that evaluate possible links with cancer and other health risks with repeated exposure to treated wood. Several chapters discuss ways to measure exposure and review various approaches to risk assessment and management. Because treated wood products last a long time, the book also considers the disposal of treated wood in terms of human and environmental impact. It explores novel disposal technologies and practical strategies for complying with regulatory phase-outs of certain treated wood products within the U.S., Canada, Europe, Australia, and many Asian countries. These include recycling, bioremediation, thermal treatment, and landfills.Environmental Impacts of Treated Wood provides a timely compilation of perspectives necessary for making informed, conscientious decisions in the production, use, and disposal of treated woods that will minimize the environmental impact and human exposure risks associated with treated wood products today.

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This volume discusses recent advances in research regarding the evolution of specific and nonspecific defense responses in a taxonomically diverse array of species. Topics regarding invertebrates include the protective mechanisms (cellular and molecular) employed by insects, the protective roles of lectins, and the self-nonself discrimination revealed by tissue incompatibility reactions. With vertebrates, the evolution of the immunoglobulin-related superfamily of recognition molecules (including immunoglobulins and the major histocompatibility complex molecules) is examined over several chapters. Other topics reviewed include the evolution of nonimmunoglobulin mediators of defense (e.g., cytokines and eicosanoids), lymphocyte subpopulations (including effects of ambient temperature on function) and the phylogenetic emergence of natural killer cells. Phylogenesis of Immune Functions provides invaluable information for evolutionary biologists, as well as all immunologists and other researchers interested in discovering how inhabitants in our increasingly threatened biosphere protect themselves against environmental pathogens and toxins.

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The latest data on the pathogenesis of ulcer disease is presented in this text, with the emphasis that an understanding of the pathogenesis and etiology of ulcer diseases represents the most rational approach to pharmacology - the prevention and treatment of ulcer disease. Early and late biochemical and functional changes, morphologic stages of the injury and healing phases, as well as vascular factors in ulceration are highlighted. In addition, new pathogenetic elements on neuroendocrine and other endogenous modulators and circadian rhythms in ulcerogenesis are covered. The section on new pharmacology consists of several chapters presenting new animal models of gastric, small intestinal and colonic ulcers because in vivo models represent the basis to test and accurately detect new antiulcer drugs. A large series of chapters cover new drugs for ulcer prevention and treatment. This book is indispensible to investigators in basic and applied research, academic and industrial pharmacologists and clinicians in gastroenterology.

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This monograph will put the topic of Cryopreservation of Plant Cells and Organs in perspective. Originally published in 1985.

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Since the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At least two subtypes of receptors, designated ETA and ETB, have been identified through biochemical and pharmacological techniques. These subtypes are cloned and expressed and additional subtypes appear to exist. The biochemical events involved in the signal transduction processes that ultimately activate the cellular machinery involved in the end-organ responses are presented, as are the mechanisms by which the receptors recognize specific and different G-proteins. Functions mediated by the receptors at the cellular, tissue and, organ level are reviewed in detail, as well as the roles that they may play a part in the physiologic and pathophysiologic processes in animals and in humans.This book is unique in its breadth of scope. The most recent and important advances, from the intracellular level of the nucleus to the functional effect that endothelin receptors mediate in intact organs, are compiled and reviewed.

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The deployment of software patches can be just as challenging as building entirely new workstations. Training and support issues can haunt even the most successful software launch for months. Preparing for the rigors of software deployment includes not just implementing change, but training employees, predicting and mitigating pitfalls, and managing expectations. Software Deployment, Updating, and Patching provides the skills you need to develop a comprehensive strategy for tracking and managing system configurations, as well as for updating and securing systems with the latest packs and patches. Written by two of Microsoft’s top experts, this clear and concise manual demonstrates how to perform inventories of IT assets, test compatibility, target deployment, and evaluate management technologies. It also shows you how to create and implement your own deployment plans with recovery and remediation options, and how to recognize potential vulnerabilities.

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During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors. Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth.This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation. In addition, aspects of the cellular action of these growth factors through their receptors and how this impacts normal cellular function are discussed. The book will provide valuable information for researchers in physiology, biology, endocrinology, and metabolism.

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Cell Interactions in Atherosclerosis covers the scientific foundations of the most important disease inflicting the developed world today. It presents a collection of topical aspects on the general theme of cell interactions in atherosclerosis, providing authoritative, up-to-the-minute accounts of how new developments in cell biology have advanced our understanding of these cellular interactions. The book is amply illustrated with electron micrographs and light micrographs incorporating modern cytochemical procedures. Cell Interactions in Atherosclerosis will interest all medical and scientific professionals dealing with atherosclerosis and heart disease.

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The purpose of this volume is to emphasize the fact that biological trace element research is a multidisciplinary science which requires a prudent combination of biological insight and analytical awareness. The text frequently stresses that accurate measurements on biologically and analytically "valid" samples hold the key for success in future investigations. It reminds the analytical scientists and the life sciences researchers that their perceptions should extend beyond conventional limits - namely, the former as generators of data and the latter as interpreters of those findings. This book enables the reader to understand the intricacies of elemental composition studies in biological systems, and also provides a valuable source of information to biologists, biochemists, physicians, nutritionists and related scientific workers who intend to draw meaningful conclusions from the analytical findings.

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Recognized for their superior strength, corrosion/oxidation resistance, and biocompatibility, titanium alloys are particularly intriguing to engineers, scientists, and metallurgists in aerospace, biomedical, and other industrial applications. Titanium Alloys: An Atlas of Structures and Fracture Features uses award-winning micrographs and fractographs to illustrate how alloy microstructures are affected by various thermomechanical treatments present in real world operating conditions.This book is the first of its kind to compile microstructural and fracture features for titanium alloys and titanium aluminides as well as capture its fractographic features together with the conditions that produced failure. The author discusses the physical metallurgy of titanium alloys as a standard for observing microstructures and their failures. Then she combines the skillful use of scanning electron microscopy in fracture analysis and an eye for detail to deliver a visual presentation of fracture surfaces generated under different loading conditions, including ductile, fatigue, intergranular, and cleavage fractures. Especially helpful to those engaged in failure analysis of titanium components, the book includes a case study applying key criteria to the service failure of a defective titanium alloy component. Supported byadditional background data such as types, compositions, phase transformations, microstructures, and typical fractographs, Titanium Alloys: An Atlas of Structures and Fracture Features offers exceptional insight into the structure-property correlations of titanium alloys.

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The Amphipathic Helix is a comprehensive volume discussing amphipathic helices in systems as diverse as serum lipoproteins, lung surfactant, cytotoxic peptides, ion channels, mitochondrial targeting, peptide hormones, G proteins, T-cell recognition, DNA binding proteins, and antifreeze proteins. The book also includes general introductory material that defines amphipathic helices, discusses methods to identify amphipathic helical segments from the amino acid sequence of a protein, illustrates how amphipathic helices can be used in the de novo design of peptide and protein structures, and describes how these helices stabilize protein structures. There is also a section on techniques to determine helix orientation in a membrane environment using polarized attenuated total reflection infrared spectroscopy or solid state NMR spectroscopy. Recent developments on all these topics have been discussed by leading experts in this reference for researchers and students in biochemistry, biophysics, and pharmacology.

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The current technology and its applications in flow cytometry are presented in this comprehensive reference work. Described in explicit detail are the instrumentation and its components, and applications of the technology in cell biology, immunology, pharmacology, genetics, hematology and clinical medicine. Methods for data analysis, including both hardware and software, and explicit experimental techniques for making specific measurements are presented.Material is divided by topic into two volumes: Volume I covers instrumentation, genetics, and cell structure; Volume II contains material on cell function studies by flow cytometry.This reference is essential for both the novice and the experienced investigator using flow cytometry in research, and for students of cell biology, biomedical engineering, and medical technology.

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Thyroid Diseases: Clinical Fundamentals and Therapy provides a wide-ranging examination of all clinically significant areas of thyroid diseases. Underlying physiological principles are closely linked to the clinical situation and practical therapeutic interventions. The book examines the clinical course, therapy, and final outcome of thyroid diseases, particularly the bimodal and transient evolution of several thyroid diseases. It also discusses the medical, surgical, and radiometabolic therapy of thyroid diseases, stressing the pros and cons of each therapeutic modality. More than 80 acknowledged experts from North America, Europe, and Japan have contributed to this exceptional reference volume, making it essential for physiologists, clinical endocrinologists, radiologists, researchers in nuclear medicine, oncologists, and radiotherapists.

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Brain Slices in Basic and Clinical Research describes advancements in the field of brain function and dysfunction through use of central nervous system slice preparations. Topics are authored by leading scientists and include the following:Mechanisms of synaptic plasticity as the basis of memory processes Chaos and synaptic variability Brain calcium currents Glutamate receptors Pathophysiology of excitotoxins Cerebral hypoxia-ischemia Neuronal injury Free radicals Optical methods of measuring brain metabolism Voltammetry in brain slices Calcium imaging Patch-clamp recording and application of macromolecules through patch-clamp pipettes in brain slices Intracellular double labeling of various neuronal populations Use of brain slices in teaching neurophysiological methodsMost of the topics are published in book format for the first time, and some of the techniques are more fully detailed than in any other book.

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This unique volume contains reviews by some of the most prominent immunologists in the world. The authors present vital facts for each of their areas of expertise and provide individual perspectives on how their own contributions were developed and how these contributions influenced general immunological thinking and development. This impressive collection of personal reviews by these internationally renowned immunologists makes The Immunologic Revolution an important and lasting contribution to the entire biomedical community.

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The cloning of the SRY gene and the attainment of XX mice transgenic for the Sry gene opened a new era in research on sex determination. This book surveys current knowledge of sex chromosomes and sex determination in all vertebrate classes, relying on the restriction of genetic recombination in sex chromosomes as the unifying concept of this subject. The book's interdisciplinary approach integrates contributions from the fields of cytogenetics, molecular biology, developmental biology, and evolutionary genetics. A detailed treatment of the meiotic behavior of sex chromosomes is featured, and the entire text is supplemented by numerous schemes, drawings, and electron micrographs.The book will be valuable to general cytogeneticists, vertebrate zoologists, and veterinarian and medical practitioners interested in the foundations of sex determination and the current knowledge of sex chromosomes. It will also interest students in advanced undergraduate and graduate courses in these areas.

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This up-to-date reference describes how retinoids and carotenoids function in the skin and how they can be utilized to prevent and treat a wide variety of skin diseases, as well as advance biomedical research in relation to cancer treatment and immunology. Providing an in-depth update on the pharmacology, pharmacodynamics, and new applications of retinoid therapy, this source also addresses topics outside of dermatology, such as vitamin A nutrition, and the role of antioxidants in aging, metabolic activation, and cellular signaling. With chapters by internationally recognized authorities in specialties ranging from biochemistry and nutrition to molecular biology and clinical science, this source will stand as the only up-to-date source on the topic.

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After a century of research, several lines of evidence now indicate that the ability of adenosine to directly control inflammatory cells has a major impact on the functions of the inflammatory and immune systems. Consequently, many promising therapeutic approaches are beginning to emerge that focus on the modulation of adenosine, including the development of compounds that interfere with the breakdown of adenosine, as well as specific agonists and antagonists of various adenosine subtypes. Some of these compounds have already entered clinical trials. While information on the role of adenosine is growing rapidly, until now it has remained scattered in the literature.Edited by three pioneering researchers in the field, Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases presents the first single volume compilation of reviews on how adenosine, acting on its cellular receptors, regulates immune responses. The book is organized to provide the reader with a general overview of adenosine receptors, delving into molecular biology, cell biology, and pharmacology. Separate chapters focus on the role of adenosine receptors in regulating the function of the various cell types that are involved in immune responses. Further chapters delineate the role of purinergic signaling in the pathophysiology of a variety of disease states associated with an overzealous or insufficient immune response. These include autoimmune diseases, asthma, atherosclerosis, ischemia-reperfusion injury, and cancer. Much of the methodology and findings documented in this text may well lead to new therapeutic modalities for pathologies such as ischemia and reperfusion, heart disease, wound healing, tumors, pain, and a variety of central nervous system diseases including Parkinson’s, Alzheimer’s, and epilepsy, as well as mood and sleep disorders. This resource provides background and direction for those researchers entering the field of adenosine and inflammatory disease, and provides a comprehensive reference for experienced investigators.

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The increase in private property value, growth of underground and multilevel development, and the emergence of 3D technologies in planning and GIS drives the need to record 3D situations in cadastral registration. 3D Cadastre in an International Context: Legal, Organizational, and Technological Aspects demonstrates how to record 3D scenarios in order to improve insight into overlapping constructions. This book emphasizes the technical aspects of cadastral registration, focusing on four main topics: context (in which 3D situations in seven countries are studied); the framework for modeling 2D and 3D situations; models for a 3D cadastre; and realization of a 3D cadastre. The book presents preliminary solutions for issues related to efficient methods for 3D data collection, 3D data structuring and modeling, organization of 2D and 3D objects in one environment, 3D database creation and 3D analyzing.

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The latest advances in process monitoring, data analysis, and control systems are increasingly useful for maintaining the safety, flexibility, and environmental compliance of industrial manufacturing operations. Focusing on continuous, multivariate processes, Chemical Process Performance Evaluation introduces statistical methods and modeling techniques for process monitoring, performance evaluation, and fault diagnosis.This book introduces practical multivariate statistical methods and empirical modeling development techniques, such as principal components regression, partial least squares regression, input-output modeling, state-space modeling, and modeling process signals for trend analysis. Then the authors examine fault diagnosis techniques based on episodes, hidden Markov models, contribution plots, discriminant analysis, and support vector machines. They address controller process evaluation and sensor failure detection, including methods for differentiating between sensor failures and process upset. The book concludes with an extensive discussion on the use of data analysis techniques for the special case of web and sheet processes. Case studies illustrate the implementation of methods presented throughout the book.Emphasizing the balance between practice and theory, Chemical Process Performance Evaluation is an excellent tool for comparing alternative techniques for process monitoring, signal modeling, and process diagnosis. The unique integration of process and controller monitoring and fault diagnosis facilitates the practical implementation of unified and automated monitoring and diagnosis technologies.

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Offers an intuitive, detailed, and easy to understand practical introduction to fluid mechanics for all disciplines of engineering Provides in-depth and detailed coverage of open channel flow that is especially valuable for civil and environmental engineers Balances theory with real-world applications Uses state-of-the-art mathematical software, Mathcad for teaching and detailed problem solving, making this textbook an exceptional choice for learning fluid mechanics in the 21st century Contains examples with detailed solutions and graphic illustrations using Mathcad, homework problems, computer algorithms, highlighted keywords, and chapter summaries

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The development of parallel synthesis and high-throughput characterization tools offer scientists a time-efficient and cost-effective solution for accelerating traditional synthesis processes and developing the structure-property relationships of multiple materials under variable conditions. Written by renowned contributors to the field, Combinatorial and High-Throughput Discovery and Optimization of Catalysts and Materials documents the impact of combinatorial methods for inorganic, organic, polymeric, and biological materials applications over the last several years.This valuable reference describes techniques for the preparation, formulation, fabrication, optimization, performance testing, and evaluation of catalysts, polymeric materials arrays, sensing materials, fuel cell battery and memory materials, semiconductor nanoclusters, dielectrics, OLED arrays, additives, organic coatings, luminescent materials, and phosphors. The book introduces some of the latest features in the development of combinatorial and high throughput workflows, including new library designs, the scale-up of combinatorially discovered materials, and innovative methods of data storage, data mining and informatics. It also points to active research in the development of intelligent software for data mining including multiparameter modeling and visualization. As combinatorial materials science becomes increasingly applicable to a growing number of materials and problems, Combinatorial and High-Throughput Discovery and Optimization of Catalysts and Materials provides an essential portrait of the success, challenges, and opportunities in this field for the next generation of combinatorial chemists, material scientists, and industrial chemists and academics.

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While the western world has only recently become enamored with the soybean, East Asia has been consuming and enjoying the associated health benefits of this versatile proteinaceous legume for centuries. The Japanese in particular have devoted much energy to unraveling the mysteries and revealing the science of this oil-rich bean. The Fuji Foundation for Protein Research was established to support soybean studies, which have resulted in a considerable amount of profound literature on the soy-wellness connection. Unfortunately for westerners, very little of this information has been presented in English. Soy in Health and Disease Prevention, edited by the highly distinguished Michihiro Sugano, brings the west up to speed on the latest findings concerning this common, yet most powerful health aid. Perhaps, the most authoritative book on the subject available in any language, Soy in Health and Disease Prevention presents the very latest health and nutrition research and findings available on soy products. Functional food experts from Japan, as well as other parts of the world,explore the action and diverse health effects of the common soybean. Included is the latest information with regard to soy’s impact on · Cancer prevention · Immune system function · Osteoporosis · Atherosclerosis · Aging and longevity This book is essential reading for all researchers and students involved with the study and production of functional foods. Dr. Sugano who is the current director of the Fuji Foundation has published over 400 journal articles, as well as 80 book chapters. His primary area of research is in food functional factors, predominantly regulation of lipid metabolism.

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On the job or in the field, when facing a problem with differential equations and boundary conditions, most likely you don’t have time to read through several publications in search of a method that may or may not solve your problem. Organized for quick and easy access to practical solutions, Analytical and Approximate Methods in Transport Phenomena is a reference for the day-to-day problems encountered when working with variables in heat, mass, or momentum transfer.This text is organized differently from usual resources on applied mathematics for engineers. First, it introduces a new classification system of the problem based on just three numbers, so locating the appropriate solution method is quick and easy. Second, the author presents mathematical methods with applications in mind, introducing examples, as well as common or possible solutions, before presenting any mathematical theory or method. This allows you to identify the issue you need to resolve, then apply the appropriate method to the problem at hand. The book also includes practical discussions of the consequences and applications of various solutions. The book highlights mathematical methods as tools for solving practical problems, not as a primary objective. Its structure and focus on application, with just the right amount of mathematical rigor, makes it the most effective manual available for easily finding the analytical methods needed to solve transport problems.

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Cardiovascular Molecular Imaging is based on a groundbreaking NIH symposium sponsored by the American Society of Nuclear Cardiology. The first all-inclusive guide to the targeted molecular imaging of the cardiovascular system, it includes color illustrations throughout and is packaged with a user-friendly CD-ROM with supplemental material.This reference covers new methods for the analysis and management of cardiovascular pathophysiological processes and discusses new technologies for analyzing cardiovascular receptors, gene expression, vascular structures, and biological processes that affect the heart and associated vessels.Bridging the gap between basic science and clinical applications, the contributors: Span the most recent molecular imaging procedures used to stage disease states and assess treatment outcomes for specific cardiovascular ailments Discuss the potential of molecular imaging to provide an improved understanding of the diagnosis and management of critical cardiovascular pathophysiological processes Track the identification of targeted biological markers for molecular and physiological processes and cover their possible impact on the development of new imaging instruments and technologies Consider biochemical processes and signaling events that precede pathophysiological transformations Analyze the latest imaging technologies that enable healthcare practitioners to improve the diagnosis, treatment, and evaluation of patients with cardiovascular conditions

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ATP's powerful impact on the heart and blood vessels was first described in 1929, but it was not until the 1970s that ATP was proposed as the 'purinergic' neurotransmitter in autonomic nerves. The door to this area of research was thrown open when receptors for ATP and its ectoenzymatic breakdown product adenosine were first cloned in the early 1990s. Now, rapidly accelerating research has taken scientists beyond the nervous system, to isolate receptors for purines and pyrimidines in many biological systems. Increasing evidence suggests that research into this area may lead to breakthrough applications in treating many of the most pressing health issues of today, including rheumatoid arthritis, osteoporosis, inflammation, and cancer.Nucleotides and Regulation of Bone Cell Function brings together the most important findings in the field, written by the very pioneers who have energized the research. Covering many aspects of purinergic signaling with regard to osteoblasts, osteoclasts, and chondrocytes, this volume provides an up-to-date exploration of the actions of nucleotides on skeletal cells. Supported by recent studies, this volume describes the distribution of receptors for purines and pyrimidines in skeletal tissue cells. It considers purinergic and P2 nucleotide receptor signaling in osteoclasts and osteoblasts, examines the role of purinergic signaling in regulating cartilage metabolism and chondrocyte function, and details ATP release mechanisms. It also delves into inflammation and immunomodulation, considers the pathophysiologic implications of the findings, and discusses future directions of research, including purine-related therapeutic interventions in a variety of diseases.In providing a compilation of major breakthroughs, Nucleotides and Regulation of Bone Cell Function offers the most definitive account currently available of the role played by purinergic extracellular signaling in both normative and pathologic conditions.

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The ballooning body of research devoted to hyaluronan (HA) reflects its enormous potential for various medical applications. There have been many successes of varying degrees in the development of medical products based on HA, but also some setbacks. While there is obviously ample information available on the chemistry and various properties of this macromolecule, Practical Aspects of Hyaluronan Based Medical Products is the first book devoted to systematically applying this knowledge to product development.Based on the author's extensive experience working with HA, this book explores in detail the chemistry, composition, formulation, testing, safety, effectiveness, quality control, and regulatory approval of HA medical products. It begins with a survey of the historical development and recent products based on hyaluronan. Subsequent chapters detail the rheological properties of the molecule and explore the chemical principles and methods forming the technical basis of product development, illustrated by more than 50 figures of chemical structures, reaction schemes, and rheological properties. Individual chapters then consider standards, tests, and analytical methods; safety of HA-based products for their indicated applications; and clinical performance, mechanism of action, and product characteristics.Practical Aspects of Hyaluronan Based Medical Products surveys FDA review documents as well as peer-reviewed journal articles to identify the elements essential to successful product development, namely, understanding the critical issues in the regulatory path and linking clinical performance of the products to their original design.

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Providing a significant cross-fertilization of ideas across several disciplines, Enhancement in Drug Delivery offers a unique comprehensive review of both theoretical and practical aspects of enhancement agents and techniques used for problematic administration routes. It presents an integrated evaluation of absorption enhancers and modes for promoting absorption that is especially valuable to those involved with the development of pharmaceutical, cosmetic, bioengineered, and medical products, as well as graduate students looking to study this intriguing field and those professionals involved with patents and regulatory issues.Organized by routes of administration, the book is divided into eight major sections: oral, rectal, buccal/sublingual, dermal/transdermal, nasal, vaginal/uterine, ocular, and brain. It offers fundamental as well specialized information including current findings on— · Surfactant use to accelerate macromolecule input · Targeted gastrointestinal delivery and enhanced absorption of lipophilic drugs · Permeation issues in rectal absorption · Chemical means of enhancement · Carriers for enhanced delivery to and across the skin · Methods associated with breaching the skin · Promoted buccal and sublingual absorption · Emerging ocular, nasal, vaginal, and uterine delivery systems · Carriers for overcoming the blood brain barrier Those investigators primarily involved with one specific route of delivery will be able to learn of helpful concepts and find additional stimulat

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Many specialists are not familiar with both drug delivery and the molecular biology of DNA vectors. Liposomes in Gene Delivery covers both-molecular biologists will gain a basic knowledge of lipids, liposomes, and other gene delivery vehicles; lipid and drug delivery scientists will better understand DNA, molecular biology, and DNA manipulation. Topics include an introduction to nucleic acids, a theoretical description of DNA, recombinant technology, lipids and liposomes, stability and interaction properties of lipids and liposomes, complexation of lipids and liposomes with DNA plasmids, gene expression of genosomes in various models, structure-activity relationships, and transfection models. This is an excellent introductory text for graduate students, scientists, and researchers in molecular and cell biology, genetics, biochemistry, physical chemistry, colloid science, pharmacology, molecular science, and medicine.

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Patterns, Models, and Application Development, a new book from two experts in C++, integrates a methodology for program development and covers three main categories: object modeling as a program design tool, design patterns and their modeling in C++ language structures, and a discussion of the implementation of PC hardware-related features. It addresses the gap between the ability to code and the ability to program.

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Reflecting changes in the field in the ten years since the publication of the first edition, The Handbook of Photonics, Second Edition explores recent advances that have affected this technology. In this new, updated second edition editor Mool Gupta is joined by John Ballato, strengthening the handbook with their combined knowledge and the continued contributions of world-class researchers.New in the Second Edition:Information on optical fiber technology and the economic impact of photonics Coverage of emerging technologies in nanotechnology Sections on optical amplifiers, and polymeric optical materialsThe book covers photonics materials, devices, and systems, respectively. An introductory chapter, new to this edition, provides an overview of photonics technology, innovation, and economic development. Resting firmly on the foundation set by the first edition, this new edition continues to serve as a source for introductory material and a collection of published data for research and training in this field, making it the reference of first resort.

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Soy is prized by the food industry for both its versatility and the major role it plays in food functionality. However, only a limited amount of information is available explaining soy's full potential in food applicability. Soy Applications in Food provides insight into the different types of soy ingredients available for consumption and details the processing conditions required for their successful application in food.Comprehensive and complete, the book offers a wealth of information about soy health benefits, the current soy food market, and the processing of soybeans into different soy ingredients. It discusses the use of soy protein in baked goods, pasta, cereal, meat products, and food bars. The book also addresses how to process soybeans into soy milk, soy beverages, and textured soy protein; how to select identity-preserved soybeans for various food applications; how to overcome the "beany" flavor of some soy products; and how soy protein is fulfilling the need for protein in underdeveloped countries. Featuring contributions from industry experts with years of experience in the field, Soy Applications in Food is a valuable resource for obtaining information on the technical and practical applications of soy ingredients.Mian N. Riaz talks about his books on the CRC Press YouTube Channel.

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The engineering community generally accepts that there exists only a small set of closed-form solutions for simple cases of bars, beams, columns, and plates. Despite the advances in powerful computing and advanced numerical techniques, closed-form solutions remain important for engineering; these include uses for preliminary design, for evaluation of the accuracy of approximate and numerical solutions, and for evaluating the role played by various geometric and loading parameters.Eigenvalues of Inhomogeneous Structures: Unusual Closed-Form Solutions offers the first new treatment of closed-form solutions since the works of Leonhard Euler over two centuries ago. It presents simple solutions for vibrating bars, beams, and plates, as well as solutions that can be used to verify finite element solutions. The closed solutions in this book not only have applications that allow for the design of tailored structures, but also transcend mechanical engineering to generalize into other fields of engineering. Also included are polynomial solutions, non-polynomial solutions, and discussions on axial variability of stiffness that offer the possibility of incorporating axial grading into functionally graded materials.This single-package treatment of inhomogeneous structures presents the tools for optimization in many applications. Mechanical, aerospace, civil, and marine engineers will find this to be the most comprehensive book on the subject. In addition, senior undergraduate and graduate students and professors will find this to be a good supplement to other structural design texts, as it can be easily incorporated into the classroom.

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Why a new book on angiogenesis and why now? For the first time concepts proposed over 30 years ago have found clinical validation. In the last two years the first antiangiogenic agents have been approved by the FDA for the treatment of cancer and age-related macular degeneration. Not surprisingly, this clinical success has raised a new set of basic and clinical questions that need to be addressed.Angiogenesis: From Basic Science to Clinical Applications presents the latest advances in basic science and reviews the status of the clinical applications of angiogenic growth factors and inhibitors. It explores current molecular and genetic findings on the regulation of angiogenesis, discusses the results of clinical trials and identifies the pathological conditions that are most likely to benefit from such treatments. Edited by a leading researcher in the field, the book includes contributions from multiple experts in their respective disciplines, supplemented by illustrations and photographs. A unique combination of information on basic science and clinical trials research, this book is truly a state-of-the-art review of the state of the science.

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Once again the National Dairy Council has produced the industry reference on the important role of dairy foods in health. Packed with the latest information from the Council’s notable scientists, the Handbook of Dairy Foods and Nutrition, Third Edition makes the case for the beneficial role of dairy foods in a variety of conditions and disease states. The handbook begins with a comprehensive overview of the nutritional content and benefits of milk and milk products including cheese and yogurt. The authors explain the effects of dairy intake on cardiovascular health and hypertension. The Dairy Council continues its research review by providing the most up-to-date information on the relationship between dairy intake and colon, breast, and prostate cancers. An entirely new chapter is devoted to addressing recent research about the role of dairy foods in weight management. Supporting the age-old advice that milk gives you strong bones and teeth, this handbook has chapters examining the evidentiary relationship between dairy intake and bone and dental health. A full chapter addresses the condition of lactose digestion, distinguishing lactose intolerance from lactose maldigestion, as well as providing research-based strategies to improve milk tolerance. A summary of dairy’s contribution to health throughout the life cycle from childhood and adolescence into adulthood and old age, rounds out this latest installment of the Dairy Council’s authoritative reference on the importance of dairy foods in the American diet. Continuing to provide state-of-the-art information on dairy products and nutrition, the Handbook of Dairy Foods and Nutrition, Third Edition is a useful resource for nutrition scientists, dietitians and other health professionals, educators, dairy researchers, and the food industry.

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This work provides the first comprehensive compendium of the progress made in understanding the process of cell death related to HIV and the potential breakthroughs in treatment that offer much promise. Combining the work of more than two dozen top researchers, this seminal volume provides clinicians and researchers with an excellent reference while also serving as an incubator to stimulate future research. It explains the fundamental biology involved with apoptosis, explains its clinical impact in HIV, and examines the newest therapeutic approaches.

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Studies in the humanities and the social sciences can be enhanced through the use of geographic information systems (GIS). However, this computer-aided method of analysis is worthless unless researchers can devote the time necessary to learn what it is, what it can do, and how to use it.Resulting from a six-year project entitled Spatial Information Science for the Humanities and Social Sciences (SIS for HSS), GIS-Based Studies in the Humanities and Social Sciences details the tools and processes for deploying GIS in economic and social analyses. Through the use of this book, readers can understand how GIS technology can be utilized in advancing studies. This volume will also encourage professionals in humanities and the social sciences to employ new GIS-based methods in their own research.

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This volume provides the origins and meanings of the names of genera and species of extant vascular plants, with the genera arranged alphabetically from A to C.

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Cloning has the potential to be an extremely valuable tool across many fields. In agriculture, the reproductive cloning of farm animals could prove to be advantageous. In clinical medicine, the employment of therapeutic cloning for cell, tissue, and organ replacement appears to be imminent. However, as with any advancement that is poised to touch human lives, the process of cloning must be looked at through the lens of the medical community’s obligation to do no harm.Epigenetic Risks of Cloning includes contributions from 32 leading researchers who are intimately involved with various aspects of cloning. At the frontlines of this science, they are best positioned to explain what is really occurring. With chapters dedicated to each of the animal models being employed for experimentation, the text presents a detailed accounting of cloning methods, an objective review of current findings, and an even-handed discussion of potential concerns. While procedures utilizing a variety of somatic cell types to create cloned animals have proven to be repeatable, efficient consistency has proven to be elusive at best. Less than four percent of reconstructed embryos typically develop to adulthood. This low success rate is the cumulative result of inefficiencies occurring at every stage of development. Epigenetic Risks of Cloning considers the very real consequences of those inefficiencies. In addition to embryonic loss, cloning experiments have experienced very high rates of fetal, perinatal, and neonatal loss, as well as the production of abnormal offspring. At present, there is a legitimate concern that the propensity for epigenetic errors could be paralleled in human embryos. This book offers an excellent opportunity to become acquainted with the current state of cloning, both the methods being utilized, as well as the risks being realized.

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Until now, there has not been any work that systematically presents the subject of acoustic fish reconnaissance, details all major aspects of applying acoustic equipment in commercial fish reconnaissance, and offers sufficient analysis of the effectiveness of fish-finding techniques. Acoustic Fish Reconnaissance responds to this need by providing the first overview of the theoretical and practical aspects of acoustic search, detection, interpretation, and population estimation for commercial benefit.This book pays particular attention to the theory and practice of accounting surveys for quantitative estimation of biological resources and fishing conditions in traditional fishing areas. It also analyzes various applications of acoustic technique, based upon the authors' extensive investigations. The text includes the results of the applicability of fish-finding instruments, and offers recommendations on the development of improved acoustic techniques for commercial fleets.

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You are the first to arrive at the scene. You secure the area, and record what the human eye can see so far. You begin your search. You come across what appears to be physical evidence, and proceed to carefully document, package, and transport it to the lab. You fill out the routine paperwork, and feel secure in the knowledge that you have done everything possible to uncover every piece of crucial evidence - but have you?Co-authored by two seasoned forensic professionals, the Illustrated Guide to Crime Scene Investigation is an essential reference that explains the protocols used in successful crime scene investigation. It presents straightforward and scientifically supported procedures in a vivid pictorial format that explain how to accurately and efficiently document what has been left behind at the scene of a crime. This comprehensive resource presents the concept of SCRIPT: the Searching for and Collection of, Recording, Initializing, Packaging, and Transporting of physical evidence from the scene of a forensic inquiry to a forensic laboratory. It outlines this methodology by providing step-by-step instructions, over 400 photographs, other illustrations, and short narrative segments that guide you through crime scene investigations involving burglary, homicide, robbery, sex crime, and arson or explosion. If you want to be confident that you have uncovered and carefully processed every bit of potential physical evidence on the scene, then the Illustrated Guide to Crime Scene Investigation is the one reference to have with you every time.

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In the search for an effective treatment for Alzheimer's disease, APP is a unique model protein that illustrates the wide array of basic and sophisticated characterization techniques available. Exploring a variety of biological techniques to clarify the structure and function of this transmembrane protein, this text presents each method with detailed, step-by-step protocols to achieve reproducible results and provide a framework for studying other membrane proteins.

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While mice have always been highly popular laboratory subjects, their suitability for genetic engineering has solidified their position as today's lab animal model of choice. However, their increased use in genetic studies has created a demand for input on phenotyping that is not always easily met. To improve the flow of information on the pathology of mice with spontaneous or genetically engineered mutations, prominent researchers organized a series of meetings. Recognizing other needs, the organizers gradually broadened their focus, until finally they expanded to provide an overview of the entire field of genetically engineered models.The Genetically Engineered Mice Handbook is an extension of those meetings. It offers an introduction for those entering into this area of research, while also serving as a resource for those presently employing mice as laboratory models. Highly comprehensive, this volume covers pertinent aspects of genetically engineered mice, including the use of models for developmental biology and the monitoring of laboratory colonies. With contributions from nearly five-dozen leading researchers, the text presents systematic approaches for analyzing mutant mice for specific medical applications, details a variety of methods for creating mutants and includes information that is particularly hard to access dealing with legal responsibilities.This essential reference examines commonly used traditional, as well as emerging, technologiesTo address the purpose of the original meeting, the Genetically Engineered Mice Handbook directs researchers to the best public websites, and offers instruction on how to use them. In the past, as their work dictated, researchers would seek out experts on particular organ systems. Now groups of experts work together to generate these websites, providing the latest data as well as discussions over points of debate. These sites do not eliminate the need for a trained pathologist, but they do provide reference materials for those lacking expertise in particular anatomic structures. They also offer much greater numbers of examples than are available in print, from which biomedical researchers can draw.

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The pharmaceutical industry is on the verge of an exciting and challenging century. Advances in pharmaceutical sciences have dramatically changed the processes of discovery and development of new therapeutic drugs and, in turn, resulted in an extraordinary increase in the potential prophylactic and therapeutic interventions. In this atmosphere, an intimate understanding of the mechanisms of pharmacokinetic and pharmacodynamic activity and the processes of drug evaluation is essential.Clinical Trials of Drugs and Biopharmaceuticals provides an overview of current procedures and major issues involved in drug and biopharmaceutical development. The book examines critical biochemical and pharmaceutical considerations for trials conducted during each phase of clinical development. It also reports information related to early pre-clinical evaluations of pharmacological activities and safety before proceeding with initiation of clinical trials. The sections focus on clinical assessments of drugs and biopharmaceuticals such as cardiovascular, respiratory, central nervous system, gastrointestinal and liver, genitourinary, skin, metabolism, and chemotherapeutic drugs as well as vaccines, biotechnology-derived therapeutics, and plant-based medicines. Practical and informative, this step-by-step guide includes information on all four phases of clinical trials prior to licensure and covers the design of post-marketing studies. The editors examine how recent advances and increased demand for safer and more effective drugs have changed the process by which drugs are developed and approved.

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