Search results for ""author seth""

In Crop Rotation and Cover Cropping, you can learn some of the thinking behind—and the actual nuts and bolts of—laying out a rotation for your farm. This volume, part of the NOFA guides, covers: Historical roots of cover-crop techniques Thinking beyond this season's cash crop (disease and pest reduction, weed suppression, cash vs. cover crops) What is a good rotation? (mapping the farm, grouping crops, sample groupings) The economics of rotations and cover cropping (organizing your work, reducing labor inputs, land and cover-crop seed costs) Including on-farm examples and detailed appendices.

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Have you heard about artificial intelligence (AI) and big data but felt they are technologies too big or too complicated for you or your business? Do you imagine AI as a Hollywood science fiction stereotype or something in the far and distant future?Take heart. AI is none of those things. It’s part of our everyday lives, and it has the power to transform your business. This book will put AI, big data, the cloud, robotics, and smart devices in context. It will reveal how these technologies can dramatically multiply any businesses—including yours—by strategically using your data’s latent, transformative potential. Noted business leader, data consultant, and Columbia professor Asha Saxena has distilled her twenty-seven years of experience teaching Fortune 500 leaders in this powerful and insightful book. In The AI Factor, business leaders will learn how to understand the data they already have and how to use it innovatively to grow their businesses using Saxena’s unique methodology.

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At its core, the goal of any basketball team is relatively simple: take and make good shots while preventing the opponent from doing the same. But what is a “good” shot? Are all good shots created equally? And how might one identify players who are more or less likely to make and prevent those shots in the first place? The concept of basketball “analytics,” for lack of a better term, has been lauded, derided, and misunderstood. The incorporation of more data into NBA decision-making has been credited—or blamed—for everything from the death of the traditional center to the proliferation of three-point shooting to the alleged abandonment of the area of the court known as the midrange. What is beyond doubt is that understanding its methods has never been more important to watching and appreciating the NBA. In The Midrange Theory, Seth Partnow, NBA analyst for The Athletic and former Director of Basketball Research for the Milwaukee Bucks, explains how numbers have affected the modern NBA game, and how those numbers seek not to “solve” the game of basketball but instead urge us toward thinking about it in new ways. The relative value of Russell Westbrook’s triple-doubles Why some players succeed in the playoffs while others don’t How NBA teams think about constructing their rosters through the draft and free agency The difficulty in measuring defensive achievement The fallacy of the “quick two” From shot selection to evaluating prospects to considering aesthetics and ethics while analyzing the box scores, Partnow deftly explores where the NBA is now, how it got here, and where it might be going next.

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There is widespread concern today about the “radicalization” of young muslim men, and the deprived areas of Western cities are believed to have become breeding grounds of home-grown extremism. But how do young Muslims growing up in the cities of the West really live? This book takes us beyond the rhetoric and into the housing estates on the outskirts of Paris to meet Adama, Radouane, Hassan, Tarik, Marley, and a shadowy figure whose name suddenly and brutally became known to the world at the time of the Charlie Hebdo shootings: Amédy Coulibaly. Seeing Amédy through the eyes of close friends and other young Muslim men in the neighbourhoods where they grew up, Fabien Truong uncovers a network of competing loyalties and maps the road these youths take to resolve the conflicts they face: becoming Muslim. For these young men, Islam stands, often alone, as a resource, a gateway – as if it were the last route to “escape” without betrayal and to “fight” in a meaningful and noble way. Becoming Muslim does not necessarily lead to the radicalized “other”. It is more like a long-distance race, a powerful reconversion of the self that allows for introspection and change. But it can also lead to a belligerent presentation of the self that transforms a dead-end into a call to arms.

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There is widespread concern today about the “radicalization” of young muslim men, and the deprived areas of Western cities are believed to have become breeding grounds of home-grown extremism. But how do young Muslims growing up in the cities of the West really live? This book takes us beyond the rhetoric and into the housing estates on the outskirts of Paris to meet Adama, Radouane, Hassan, Tarik, Marley, and a shadowy figure whose name suddenly and brutally became known to the world at the time of the Charlie Hebdo shootings: Amédy Coulibaly. Seeing Amédy through the eyes of close friends and other young Muslim men in the neighbourhoods where they grew up, Fabien Truong uncovers a network of competing loyalties and maps the road these youths take to resolve the conflicts they face: becoming Muslim. For these young men, Islam stands, often alone, as a resource, a gateway – as if it were the last route to “escape” without betrayal and to “fight” in a meaningful and noble way. Becoming Muslim does not necessarily lead to the radicalized “other”. It is more like a long-distance race, a powerful reconversion of the self that allows for introspection and change. But it can also lead to a belligerent presentation of the self that transforms a dead-end into a call to arms.

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With all the responsibilities parents have raising children, one key area is often neglected: helping sons and daughters understand and grow in their spiritual gifting--at any age. In this groundbreaking resource, children's pastor Seth Dahl helps parents minister to and with their children, shaping them into the gifted individuals God designed them to be, while simultaneously doing damage to the kingdom of darkness. He covers important topics such as · creating a culture of faith at home · helping your children navigate spiritual realities · guiding your children to live out the kingdom in their everyday lives · and more! By using the practical tools offered here, you will guide your children effectively and confidently. Bring the life-changing power of God into your home--and raise Spirit-led kids.

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The Toll-House has a long and terrible history as a place of death. But Jack Barnes doesn't believe in spirits. His travelling companions, Messrs. Meagle, Lester, and White, wager that he might be convinced otherwise if they all spend a night together in the house. Four men go in, but will four come out?W. W. Jacobs was an English author, well-known for his story "The Monkey's Paw."

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A global security expert draws on psychological insights to help you master the art of social engineering—human hacking. Make friends, influence people, and leave them feeling better for having met you by being more empathetic, generous, and kind.Eroding social conventions, technology, and rapid economic change are making human beings more stressed and socially awkward and isolated than ever. We live in our own bubbles, reluctant to connect, and feeling increasingly powerless, insecure, and apprehensive when communicating with others.A pioneer in the field of social engineering and a master hacker, Christopher Hadnagy specializes in understanding how malicious attackers exploit principles of human communication to access information and resources through manipulation and deceit. Now, he shows you how to use social engineering as a force for good—to help you regain your confidence and control. Human Hacking provides tools that will help you establish rapport with strangers, use body language and verbal cues to your advantage, steer conversations and influence other’s decisions, and protect yourself from manipulators. Ultimately, you’ll become far more self-aware about how you’re presenting yourself—and able to use it to improve your life. Hadnagy includes lessons and interactive “missions”—exercises spread throughout the book to help you learn the skills, practice them, and master them. With Human Hacking, you’ll soon be winning friends, influencing people, and achieving your goals.

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Will and company continue their journey across the apocalyptic wasteland of the midwest with Johnny Eldritch and the Red Mother in hot pursuit. Ben catches up with Redjaw and Bunny and looks to settle old scores. Old friends return and a stunning betrayal leads to bloodshed.Collects issues 11 through 15.

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The Being of the Beautiful collects Plato’s three dialogues, the Theaetetus, Sophist, and Statesmen, in which Socrates formulates his conception of philosophy while preparing for trial. Renowned classicist Seth Benardete’s careful translations clearly illuminate the dramatic and philosophical unity of these dialogues and highlight Plato’s subtle interplay of language and structure. Extensive notes and commentaries, furthermore, underscore the trilogy’s motifs and relationships.“The translations are masterpieces of literalness. . . . They are honest, accurate, and give the reader a wonderful sense of the Greek.”—Drew A. Hyland, Review of Metaphysics

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Theaetetus, the Sophist, and the Statesman are a trilogy of Platonic dialogues that show Socrates formulating his conception of philosophy as he prepares the defense for his trial. Originally published together as The Being of the Beautiful, these translations can be read separately or as a trilogy. Each includes an introduction, extensive notes, and comprehensive commentary that examines the trilogy's motifs and relationships."Seth Benardete is one of the very few contemporary classicists who combine the highest philological competence with a subtlety and taste that approximate that of the ancients. At the same time, he as set himself the entirely modern hermeneutical task of uncovering what the ancients preferred to keep veiled, of making explicit what they indicated, and hence...of showing the naked ugliness of artificial beauty."—Stanley Rose, Graduate Faculty Philosophy JournalSeth Benardete (1930-2001) was professor of classics at New York University. He was the author or translator of many books, most recently The Argument of the Action, Plato's "Laws," and Plato's "Symposium," all published by the University of Chicago Press.

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The poems in Zachariah Wells' second collection range from childhood to dimly foreseen events in the future; they idle on all three of Canada's coasts, travel the open road, take walks in the city and pause on the banks of country streams and ponds. Using an eclectic array of techniques and forms, from haiku to a crown of sonnets, in a voice that is personal but never private, Wells sketches a fragmentary biography of a life in progress, a study of post-industrial nomadic restlessness in a rootless age. Both elegiac and celebratory, "Track & Trace" considers how we live, how we shape our lives, and how we are eroded and drifted by time and circumstance.

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World-renowned illustrator Seth returns with three new Christmas ghost stories for 2020. Retired officer Colonel Mortimer takes a lease on the mansion of Brentwood, the grounds of which share the ruins of an older house, including a strange, vacant doorway, but eerie events begin to unfold and Mortimer’s son falls ill. As the supernatural takes hold, Mortimer resolves to do what he must to save his son even as he ventures further into an increasingly horrifying place.

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After her parents pass away, young Rosamond is raised by her nurse in the ancestral home of her aunt, Miss Furnivall. One day the two uncover an exceptionally beautiful old portrait? A relative, distant or close? And is that the strange sound of a distant organ, or simply the wind?

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From finding common ground with warlords, introducing the Taliban to change, and working with NFL greats such as Marshawn Lynch, this uplifting and inspirational memoir from coach and personal development expert, Tareq Azim, will help you build a relationship with fear and embrace your own power.A descendant of Afghan nobles, Tareq Azim’s family was forced to flee their homeland in 1979. He assimilated in the United States through his love of sports, excelling in wrestling, boxing, and football. In 2004, Azim decided to visit his home country, and upon arriving, he discovered countless children living on the streets, waiting for the inevitable recruitment into terrorist networks and anti-peace militias. Azim’s close encounter with the ravages of a war-torn society taught him how pain can generate the most intense forms of fear, anxiety, and depression. He had found his salvation through sports and physical activity, and he knew these children could, too. He put his method to the test and created the Afghan Women’s Boxing Federation, the official governing body for women’s sports for the National Olympic Committee and the first ever in the history of any Islamic republic, proving that Afghanistan was ready for social change by addressing the harms of accumulated trauma. Now, his remarkable full story is revealed in this book that is both a memoir and a roadmap. Through his own experiences, he effortlessly explains how fear is an invitation to seek a deeper feeling within—a feeling that is achieved when we engage in righteous and sincere struggle. Only then will our choices be guided by values that help us avoid the pitfalls of moral and personal failure. Featuring actionable advice and varied clear-eyed case studies, including MMA star Jake Shields, former congresswoman Tulsi Gabbard, and San Francisco 49ers owner Jed York—Empower is the ultimate guide to living a life understanding that fear is there to help you.

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Defending society against natural hazards is a high-stakes game of chance against nature, involving tough decisions. How should a developing nation allocate its budget between building schools for towns without ones or making existing schools earthquake-resistant? Does it make more sense to build levees to protect against floods, or to prevent development in the areas at risk? Would more lives be saved by making hospitals earthquake-resistant, or using the funds for patient care? What should scientists tell the public when – as occurred in L’Aquila, Italy and Mammoth Lakes, California – there is a real but small risk of an upcoming earthquake or volcanic eruption? Recent hurricanes, earthquakes, and tsunamis show that society often handles such choices poorly. Sometimes nature surprises us, when an earthquake, hurricane, or flood is bigger or has greater effects than expected from detailed hazard assessments. In other cases, nature outsmarts us, doing great damage despite expensive mitigation measures or causing us to divert limited resources to mitigate hazards that are overestimated. Much of the problem comes from the fact that formulating effective natural hazard policy involves combining science, economics, and risk analysis to analyze a problem and explore the costs and benefits of different options, in situations where the future is very uncertain. Because mitigation policies are typically chosen without such analysis, the results are often disappointing. This book uses general principles and case studies to explore how we can do better by taking an integrated view of natural hazards issues, rather than treating the relevant geoscience, engineering, economics, and policy formulation separately. Thought-provoking questions at the end of each chapter invite readers to confront the complex issues involved. Readership: Instructors, researchers, practitioners, and students interested in geoscience, engineering, economics, or policy issues relevant to natural hazards. Suitable for upper-level undergraduate or graduate courses. Additional resources can be found at: http://www.wiley.com/go/Stein/Playingagainstnature

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Aristotle's much-translated On Poetics is the earliest and arguably the best treatment that we possess of tragedy as a literary form. Seth Benardete and Michael Davis have translated it anew with a view to rendering Aristotle’s text into English as precisely as possible. A literal translation has long been needed, for in order to excavate the argument of On Poetics one has to attend not simply to what is said on the surface but also to the various puzzles, questions, and peculiarities that emerge only on the level of how Aristotle says what he says and thereby leads one to revise and deepen one’s initial understanding of the intent of the argument. As On Poetics is about how tragedy ought to be composed, it should not be surprising that it turns out to be a rather artful piece of literature in its own right.Benardete and Davis supplement their edition of On Poetics with extensive notes and appendices. They explain nuances of the original that elude translation, and they provide translations of passages found elsewhere in Aristotle’s works as well as in those of other ancient authors that prove useful in thinking through the argument of On Poetics both in terms of its treatment of tragedy and in terms of its broader concerns. By following the connections Aristotle plots between On Poetics and his other works, readers will be in a position to appreciate the centrality of this little book for his thought on the whole.In an introduction that sketches the overall interpretation of On Poetics presented in his The Poetry of Philosophy (St. Augustine’s Press, 1999), Davis argues that, while On Poetics is certainly about tragedy, it has a further concern extending beyond poetry to the very structure of the human soul in its relation to what is, and that Aristotle reveals in the form of his argument the true character of human action.

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An innovative communication method for making change happen in any organization Getting Change Right presents a new view of leadership communication that says change doesn't flow top-down, bottom-up, or sideways, but inside-out. This is how change spreads through a complex system successfully-the other options are force or failure. Based on years of experience with organizations around the world, change expert Kahan presents a new model of communication, one that moves from a transactional view of information exchange to a collaborative construction of shared understanding. When the right people are having the right conversations and interactions, then they act in concert even though the situations they confront independently are impossible to predict or coordinate. This dynamic practitioner's guide to implementing change Presents the innovative co-creation communication model for creating change Reveals how communicating with a company's most valuable players is at the heart of organizational change Draws on the author's wealth of experience with Fortune 100 companies, leading government agencies, and associations Getting Change Right offers business insights and field-tested, practical techniques that can be put to work immediately.

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Delving into all aspects of designing and maintaining unique interior landscapes, this colorfully illustrated book demonstrates how to realize landscapes for a variety of different interiors, from private homes to corporate office buildings, and in styles ranging from naturalistic to abstract. Photographic examples of the authors’ own designs and the natural materials that inspired them show how to construct an infrastructure and select the right plants for different design themes, including jungles, deserts, gardens, seasonal pieces, and sanctuaries and memorials. A plant index is also included.

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The first major piece of unpublished work by Leo Strauss to appear in more than 30 years, this volume offers the public the unprecedented experience of encountering this renowned scholar as his students did. Given as a course in autumn 1959 under the title "Plato's Political Philosophy" these provocative lectures - until now, never published, but instead passed down from one generation of students to the next - show Strauss at his subtle and insightful best.

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Cosmetic Surgery after Massive Weight Loss provides a comprehensive, practical and timely review of the latest techniques used to help postbariatric patients deal with redundant tissue after weight loss surgery. Bariatric surgery can bring long-term benefits in health and overall quality of life. But it is not without complications, including loss of skin tone, sagging fat and skin, and associated functional problems. This highly illustrated text offers authoritative guidance on the surgical management of these issues. The book opens with a description of surgical options for weight loss before summarizing the psychological evaluation and medical management of the postbariatric patient. Later chapters cover cosmetic surgical options by anatomic area before outlining new approaches to tissue transfer for cancer reconstruction, techniques to avoid unfavorable results, and medicolegal issues. Provides a definitive ‘go to’ reference for trainees and practicing plastic surgeons Covers all aspects of the management of postbariatric patients, from the options for weight loss surgery to the psychological needs of the patient Gives practical advice on the approach to the patient, the formulation of individual treatment plans, and the avoidance of clinical complications

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World-renowned cartoonist Seth returns with three new ghost stories for 2021. When the Lady Gwendolen, age six, drops her doll down a staircase, her ladyship solemnly digs her fractured companion a grave. Luckily Mr Puckler, renowned doll doctor, thinks he can help—but when his daughter Else goes missing, he’s not sure whose voice he hears calling to him in the night.

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Save time and money with in-depth reviews, ratings, and details from the trusted source for a successful Las Vegas vacation. How do some guests always seem to find the best restaurants, the best shows, the best hotels—and still come home with winnings in their pockets? Why do some guests pay full price for their visit when others can save hundreds of dollars? In Las Vegas, every minute and every dollar count. Your vacation is too important to be left to chance, so put the independent guide to Las Vegas in your hands and take control of your trip. The Unofficial Guide to Las Vegas explains how Sin City works and how to use that knowledge to stay ahead of the crowd. Authors Bob Sehlinger and Seth Kubersky know that you want your vacation to be anything but average, so they employ an expert team of researchers to find the secrets, the shortcuts, and the bargains that are sure to make your vacation exceptional! Find out what’s available in every category, ranked from best to worst, and get detailed plans to make the most of your time in Las Vegas. Stay at a top-rated hotel, eat at the most acclaimed restaurants, and experience all the most popular attractions. Inside You’ll Find: Nearly 100 hotels and casinos described, rated, and ranked―the most offered by any guidebook―plus strategies for scoring the best room rate Reviews of more than 100 restaurants―a complete dining guide within the guide, plus the best buffets and brunches The best places to play for every casino game Almost 50 pages of gambling tips, including how to play, recognizing sucker games, and cutting the house advantage to the bone Critical reviews of more than 70 of Las Vegas’s best shows Complete coverage of the Las Vegas nightclub, bar, and lounge scene, with surefire advice on how to get into the most exclusive venues Detailed instructions for avoiding Strip and I-15 traffic gridlock In-depth descriptions and consumer tips on shopping and experiencing attractions Make the right choices to create a vacation you’ll never forget. The Unofficial Guide to Las Vegas is your key to planning a perfect stay. Whether you’re putting together your annual trip or preparing for your first visit, this book gives you the insider scoop on hotels, restaurants, entertainment, and more.

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Dive into the fascinating world of movie make-up effects with this stunning illustrated oral history of the art form. Masters of Make-Up Effects is a celebration of make-up artists and acclaimed make-up effects from the world of film and television. Authors Howard Berger and Marshall Julius have gleaned untold stories from the sets of cult classics (Planet of the Apes, An American Werewolf in London, The Thing), fan-favourite film and TV franchises (Star Trek, Star Wars, Harry Potter and the MCU) and modern blockbusters like Dune to chart the fascinating evolution of an industry.Lavishly illustrated with hundreds of behind-the-scenes photos, many of which have never before been seen in print or on social media, it showcases some of the most iconic make-up effects of all time, while revealing how they came to be in the artists' own words.Featuring a foreword by Guillermo del Toro, an afterword by Seth MacFarlane, and contributions from more than 50 make-up effects legends, as well as iconic actors including Doug Jones, Robert Englund, James McAvoy and Doug Bradley, and directors Mick Garris and John Landis, Masters of Make-Up Effects is the most complete book on movie make-up history ever assembled, and a must read for cinema fans everywhere.

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When you live in an ornamented world where your home is a museum of 1940s design, you don t leave the house without a hat and tie, and your wife owns a barber shop which you designed it s hard to imagine letting a documentary about you go to press with- out constructing an exquisite package for it. In Seth s Dominion, the National Film Board documentary by filmmaker Luc Chamberland about the acclaimed Canadian cartoonist, Seth has done just that. Presented here as an innovative double-spined hardcover that opens in two directions, one side opens with a photo essay narrating Seth s life while the other offers a generous sampling of Seth s art: comics and sketchbook pages, but also puppetry and New Yorker illustrations. Seth also speaks to the experience of making the documentary through a comics diary, constructed from rubber stamp images. Between these two halves lies Seth s Dominion, a masterly portrait that mixes insightful biography with vivid animation in an artful fusion of filmmaking techniques that perfectly captures Seth s manifold creative universe. From his melancholy reflections on childhood to his descriptions of his creative habits, Seth narrates his own life story enchantingly. With special features including two short animations and a taping of Seth speaking at the Drawn and Quarterly bookstore, Seth s Dominion is a triumph.

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Before he wrote 'A Series of Unfortunate Events', before the Baudelaires became orphans, even before the invention of Netflix, Lemony Snicket asked all the wrong questions. Four to be exact.This is the account of the fourth question. There was a town, and there was a train, and there was a murder. Apprentice investigator Lemony Snicket was on the train, and he thought that if he solved the murder he could save the town. In the tradition of great storytellers, from Dickens to Dahl, comes an exquisitely dark comedy that is both literary and irreverent. You’ll laugh only if you find humour in gothic and mysterious things involving detectives and crime solving. Lemony’s other literary outings in ‘A Series of Unfortunate Events’ have sold 60 million copies worldwide and been made into a Hollywood film starring Jim Carrey and a Netflix series starring Neil Patrick Harris. These regrettable developments mean that millions of fans have found out about the dreadful plight of the Baudelaire orphans, but you do not have to. You have been warned. Have you read all four mysterious titles in the Wrong Questions series? ‘Who Could That Be at the This Hour?’ ‘When Did You Last See Her?’ ‘Shouldn’t You Be in School?’ ‘Why is This Night Different from All Other Nights?’ Author Lemony Snicket was born before you were and is likely to die before you as well. He was born in a small town where the inhabitants were suspicious and prone to riot. He grew up near the sea and currently lives beneath it. Until recently, he was living somewhere else. He is a broken man, wracked with misery and despair as a result of writing 'A Series of Unfortunate Events'. He spends his days wandering the countryside weeping and moaning and his evenings eating hastily-prepared meals. Artist Seth has portrayed suspicious circumstances and shady characters in much of his work. He is a multi-award-winning cartoonist, author and artist, whose works include Palookaville and Clyde Fans.

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Theaetetus, the Sophist, and the Statesman are a trilogy of Platonic dialogues that show Socrates formulating his conception of philosophy as he prepares the defense for his trial. Originally published together as The Being of the Beautiful, these translations can be read separately or as a trilogy. Each includes an introduction, extensive notes, and comprehensive commentary that examines the trilogy's motifs and relationships."Seth Benardete is one of the very few contemporary classicists who combine the highest philological competence with a subtlety and taste that approximate that of the ancients. At the same time, he as set himself the entirely modern hermeneutical task of uncovering what the ancients preferred to keep veiled, of making explicit what they indicated, and hence...of showing the naked ugliness of artificial beauty."—Stanley Rose, Graduate Faculty Philosophy JournalSeth Benardete (1930-2001) was professor of classics at New York University. He was the author or translator of many books, most recently The Argument of the Action, Plato's "Laws," and Plato's "Symposium," all published by the University of Chicago Press.

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World-renowned cartoonist Seth returns with three new ghost stories for 2021. When Lady Jane Lynke unexpectedly inherits Bells, a beautiful country estate, she declares she’ll never leave the peaceful grounds and sets about making the house her home. But she hasn’t reckoned on the obstinate Mr Jones, the caretaker she’s told dislikes her changes, yet never seems able to be found.

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While engrossed in an account of the death of a student obsessed with his own hair, a man leans down to absently pet his dog--oblivious of the true nature of the creature crouching beside him. This classic ghost story by M.R. James is a spooky holiday delight.

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One of the titles in an exciting series of beloved, charming and spooky ghost stories, brought to life by legendary illustrator Seth. When Lady Jane Lynke unexpectedly inherits Bells, a beautiful country estate, she declares she'll never leave the peaceful grounds and sets about making the house her home. But she hasn't reckoned on the obstinate Mr Jones, the caretaker she's told dislikes her changes, yet never seems able to be found.

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There's no escaping it: everyone experiences seasons of pain and despair. In 2019, when Amber Haines resigned from her position as church curate and walked out the church doors for the last time, she entered her own season of pain and despair. That season taught her--and her husband, Seth Haines--that the journey toward hope starts with recognizing "the deep down things." In The Deep Down Things, Amber and Seth point to a simple truth: even in the darkest times, there are tangible signs of hope all around us. The authors demonstrate how tasting, touching, feeling, holding, and participating in these tangible acts of hope picks us up, builds our strength, and moves us into beauty, even in times of despair. They invite readers to participate with those signs of hope and thereby experience the divine love of God, even in the struggle of their everyday lives. A lifeline for those who desperately need it, this book helps readers overcome despair, find hope, and spread that hope to an aching world.

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The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries. The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification. Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.

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God created us to be curious. We innately wonder about the world, one another, ourselves, and our Creator. But fear of the unknown, cultural taboos, technology, or even church leaders can smother our curiosity. Popular writer Lore Ferguson Wilbert has belonged to Christian communities that discouraged curiosity. The point of the Christian life was to have the right answers, and asking questions reflected a wavering faith. But Wilbert came to discover that the Bible is a permission slip to anyone who wants to ask questions. Reflecting her own theological trajectory toward a more contemplative, expansive faith, Wilbert invites readers to foster curiosity as a spiritual habit. This book explores questions God asks us, questions we ask God, and questions we ask each other. Christianity is not about knowing good answers, says Wilbert, but about asking good questions--ones that foster deeper intimacy with God and others. A Curious Faith invites readers to go beyond pat answers and embrace curiosity, rather than certainty, as a hallmark of authentic faith. Foreword by Seth Haines.

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Boston National Historical Park is one of America's most popular heritage destinations, drawing in millions of visitors annually. Tourists flock there to see the site of the Boston Massacre, to relive Paul Revere's midnight ride, and to board Old Ironsides—all of these bound together by the iconic Freedom Trail, which traces the city's revolutionary saga.Making sense of the Revolution, however, was never the primary aim for the planners who reimagined Boston's heritage landscape after the Second World War. Seth C. Bruggeman demonstrates that the Freedom Trail was always largely a tourist gimmick, devised to lure affluent white Americans into downtown revival schemes, its success hinging on a narrow vision of the city's history run through with old stories about heroic white men. When Congress pressured the National Park Service to create this historical park for the nation's bicentennial celebration in 1976, these ideas seeped into its organizational logic, precluding the possibility that history might prevail over gentrification and profit.

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Have you ever heard someone say that climate change is simply the result of natural cycles? Or that there can't be global warming because it still gets so cold out? While the claims climate-change deniers make can seem, on their surface, quite plausible, they simply don't hold up against the evidence: Beyond a shadow of a doubt, science proves that climate change is real and primarily human-driven. But the next time a skeptic puts you on the spot, will you know what to say to end the argument?HOW TO CHANGE MINDS ABOUT OUR CHANGING CLIMATE dismantles all the most pernicious misunderstandings using the strongest explanations science has to offer. Armed with airtight arguments, you'll never be at a loss for words again no matter how convincing or unexpected the misconception you're faced with. And with our planet's future in our hands, the time to change minds is now: The sooner we can agree, once and for all, that climate change is a significant threat to our well-being, the sooner we can start to do something about it.

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