Search results for ""author roy"

Nanogel-based systems have gained tremendous attention due to their diverse range of applications in tissue engineering, regenerative medicine, biosensors, orthopaedics, wound healing and drug delivery. Nanogels for Biomedical Applications provides a comprehensive overview of nanogels and their use in nanomedicine. The book starts with the synthesis, methods and characterization techniques for nanogel-based smart materials followed by individual chapters demonstrating the different uses of the materials. Applications covered include anticancer therapy, tuberculosis diagnosis and treatment, tissue engineering, gene delivery and targeted drug delivery. The book will appeal to biologists, chemists, and nanotechnologists interested in translation research for personalized nanomedicine for health care.

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Polymer science faces the challenge of meeting growing market demand for polymers whilst achieving sustainability through environmentally friendly processes. Microwave heating has emerged as a greener technique that accelerates a variety of chemical reactions, including polymerization. Microwave-assisted reactions can be cleaner and more rapid and economic analyses suggest that the cost of curing polymers may be reduced by switching over to the use of microwaves. This book provides comprehensive coverage of microwave-assisted polymerization. The first chapter introduces readers to the theory behind the accelerating effects of microwaves on chemical reactions and covers the types of commercial microwave reactors being used for synthesis and processing of polymers that are available on the market. Subsequent chapters are organised by type of reaction, including radical homo and co-polymerizations, step growth polymerization and peptide synthesis. Importantly, analysis of processes and product properties in comparison with conventional methods is also detailed. This book will be a valuable resource for green chemists and polymer scientists and engineers who want to develop sustainable processes.

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This second volume chronicles the later stages of the outbreak of SARS-Cov-2 (COVID-19) and delineates the role of several disciplines in therapeutic and control measures highliting the response from specific coutries of note and efforts to repurpose and produce new therapeutics and vaccines. By addressing considerations of efficacy and safety of drugs and chemicals used to combat COVID-19, virtually in real-time, this book documents and highlights the advances in science and place the toxicology, pharmaceutical science, public health and medical community in a better position to advise in future epidemics.

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The most comprehensive listing of the known useful plants for this country. Compiled by a team of Colombian and international botanists from the Royal Botanic Gardens, Kew, the Humboldt Institute and numerous partner institutions, it consolidates expert-generated information linked and accessible through an online portal (ColPlantA). The checklist is accompanied by 11 chapters written by specialists, providing perspectives on the state of knowledge on the useful plants of Colombia, covering a range of topics, from taxonomic, geographic and conservation aspects, to their use in sustainable value chains and contributions to the bioeconomy, specific topics such as medicinal, edible and insecticide plants, and their representation in the Amazon region, and in Kew’s economic botany collection. The catalogue is further enriched by diverse supplementary material.

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Presenting a systematic approach to the chemistry of the p Block elements and hydrogen, this book also introduces some basic topics concerning chemical bonding, such as oxidation numbers, bond strengths, dipole moments and intermolecular forces. The chemistry is illustrated by coverage of the biological role of nitric oxide and of hydrogen bonding, and the new chemistry of carbon nanotubes. Applied aspects of the topic are developed in the two Case Studies, which examine the causes and prevention of acid rain and the inorganic chemical industry. The accompanying CD-ROMs cover silicate mineral structures, the inert pair effect and a database of chemical reactions of the p Block elements. The Molecular World series provides an integrated introduction to all branches of chemistry for both students wishing to specialise and those wishing to gain a broad understanding of chemistry and its relevance to the everyday world and to other areas of science. The books, with their Case Studies and accompanying multi-media interactive CD-ROMs, will also provide valuable resource material for teachers and lecturers. (The CD-ROMs are designed for use on a PC running Windows 95, 98, ME or 2000.)

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This book is divided into two parts. The first covers biomass modification to facilitate the industrial degradation processing and other characteristics of feedstocks. These include reduction in the general recalcitrance of plant cell wall and downstream processing costs. The second focuses on cutting edge technologies for the conversion of lignocelluloses into biofuels and other products. It describes the most up-to-date advances in natural biomass utilization systems, such as wood-feeding termites and animals that efficiently degrade lignocellulosic substrates. Consolidated bioprocessing (CBP) integrates cellulase production and cellulose hydrolysis, with pentose and hexose fermentation in a single step. This replicates what happens in the digestive systems of animals, such as termites and cows, that effectively degrade lignocellulosic substrates. CBP has the potential to reduce production costs and lower capital investment whilst increasing conversion efficiency. Currently, there are no CBP-enabling micro-organisms suitable for industrial applications. Consequently, this book presents technologies which integrate the lignocellulolytic systems of insects and other animals to advance CBP strategy for cellulosic biofuels. It covers the progress made, and challenges faced, with the utilisation of gene, catalyst, and other unique mechanisms from cellulose-eating animals, as well as cutting-edge technologies developed to reduce the general recalcitrance of feedstocks for processing. This volume makes essential reading for academics and industrial groups concerned with overcoming the challenges inherent in the biological conversion of biomass into fuels and chemicals.

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Corrosion affects every industry in which metal is involved, from manufacturing machinery to transport pipelines, and it is estimated to cost the global economy trillions of dollars per year. Many of the traditional methods for inhibiting corrosion are highly toxic (such as hexavalent chromium) or do not degrade readily in the environment (such as Benzotriazole) meaning they pose a risk to human and environmental health. Much recent work in the area has gone into searching for greener alternatives that will be both safe and effective. Beginning with a look at the fundamentals of corrosion inhibition and an explanation of the concepts of green chemistry, this book discusses various types of chemical that have been tested for their potential as greener corrosion inhibitors with reference to industrial applications. Green Corrosion Inhibition is a valuable reference for chemists and chemical engineers working in both research and design and academia who want to learn more about green corrosion inhibitors, their synthesis, design, and industrial scale applications.

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Modern research in biology increasingly relies on multiple techniques for describing structures and mechanisms. This book provides an overview of the contemporary integrated biology approaches for solving structures and understanding mechanisms of complex biological systems. It includes several methodology chapters discussing the current developments in the areas of cryo-electron microscopy (EM) and cryo-electron tomography (ET), computational biophysics, solution NMR spectroscopy, solid-state NMR spectroscopy and dynamic nuclear polarization (DNP), electron paramagnetic resonance (EPR), (photo-)chemically induced dynamic nuclear polarization (CIDNP), X-ray crystallography and small-angle X-ray and neutron scattering (SAXS/SANS). Several subsequent chapters demonstrate how these methods are used in synergy to address problems at the forefront of structural biology, with particular emphasis on examples where individual techniques are insufficient. Examples of biological systems include membrane proteins, viral protein assemblies, cytoskeleton protein assemblies, photosynthetic reaction centers, large enzyme complexes and whole cells. The book is targeted to both the current practitioners of structural biology and scientists who are interested in entering the fields of structural biology or biophysical chemistry.

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Since the early 20th century, X-ray and electron scattering has provided a powerful means by which the location of atoms can be identified in gas-phase molecules and condensed matter with sub-atomic spatial resolution. Scattering techniques can also provide valuable observables of the fundamental properties of electrons in matter such as an electron’s spin and its energy. In recent years, significant technological developments in both X-ray and electron scattering have paved the way to time-resolved analogues capable of capturing real-time snapshots of transient structures undergoing a photochemical reaction. Structural Dynamics with X-ray and Electron Scattering is a two-part book that firstly introduces the fundamental background to scattering theory and photochemical phenomena of interest. The second part discusses the latest advances and research results from the application of ultrafast scattering techniques to imaging the structure and dynamics of gas-phase molecules and condensed matter. This book aims to provide a unifying platform for X-ray and electron scattering.

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Supercapacitors can both hold large amounts of energy and charge up almost instantly. They have higher energy densities, higher efficiencies and longer lifetimes so can be used in a wide range of energy harvesting and storage systems including portable power and grid applications. Despite offering key performance advantages, many device components pose significant environmental hazards, often containing fluorine, sulfur and cyanide groups which are harmful when discarded. In recent years, there has been increasing research into more sustainable electrode materials for supercapacitor applications. In this book, readers are introduced to the extensive and ongoing research on the rationalization of low-carbon supercapacitor materials, their structures at varying scales and dimensions, the development of effective and low-cost synthesis techniques, design and architecture of green materials, as well as clarification of their electrochemical performance. It is an ideal book for researchers and industry professionals at the energy–environment nexus, searching for new advancements in supercapacitor science and technologies.

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Dynamic soft materials that have the ability to expand and contract, change stiffness, self-heal or dissolve in response to environmental changes, are of great interest in applications ranging from biosensing and drug delivery to soft robotics and tissue engineering. This book covers the state-of-the-art and current trends in the very active and exciting field of bioinspired soft matter, its fundamentals and comprehension from the structural-property point of view, as well as materials and cutting-edge technologies that enable their design, fabrication, advanced characterization and underpin their biomedical applications. The book contents are supported by illustrated examples, schemes, and figures, offering a comprehensive and thorough overview of key aspects of soft matter. The book will provide a trusted resource for undergraduate and graduate students and will extensively benefit researchers and professionals working across the fields of chemistry, biochemistry, polymer chemistry, materials science and engineering, nanosciences, nanotechnologies, nanomedicine, biomedical engineering and medical sciences.

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Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. With contributions from global leaders in the field, this book will serve as a useful reference to established researchers as well as a practical guide to those new to metallodrugs, and postgraduate students of medicinal chemistry and metallobiology.

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New technologies are made possible by new materials, and until recently new materials could only be discovered experimentally. Recent advances in solving the crystal structure prediction problem means that the computational design of materials is now a reality. Computational Materials Discovery provides a comprehensive review of this field covering different computational methodologies as well as specific applications of materials design. The book starts by illustrating how and why first-principle calculations have gained importance in the process of materials discovery. The book is then split into three sections, the first exploring different approaches and ideas including crystal structure prediction from evolutionary approaches, data mining methods and applications of machine learning. Section two then looks at examples of designing specific functional materials with special technological relevance for example photovoltaic materials, superconducting materials, topological insulators and thermoelectric materials. The final section considers recent developments in creating low-dimensional materials. With contributions from pioneers and leaders in the field, this unique and timely book provides a convenient entry point for graduate students, researchers and industrial scientists on both the methodologies and applications of the computational design of materials.

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Food Microbiology by Adams and Moss has been a popular textbook since it was first published in 1995. Now in its fourth edition, Peter McClure joins the highly successful authorship in order to bring the book right up to date. Maintaining its general structure and philosophy to encompass modern food microbiology, this new edition provides updated and revised individual chapters and uses new examples to illustrate incidents with particular attention being paid to images. Thorough and accessible, it is designed for students in the biological sciences, biotechnology and food science as well as a valuable resource for researchers, teachers and practising food microbiologists.

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On a late summer day, many years ago, a young man set out on a voyage through the mountains. He never reached his destination. When his remains were discovered by three British Columbia hunters, roughly three hundred years after he was caught by a storm or other accident, his story had faded from even the long memory of the region’s people. First Nations elders decided to call the discovery Kwäday Dän Ts’ìnchi—Long Ago Person Found. The discovery of the Kwäday Dän Ts’ìnchi man raised many questions. Who was he and how did he die? Where had he come from? Where was he going, and for what purpose? What did his world look like? But his remains, preserved in glacial ice for centuries, offered answers, too—as did the traditional knowledge and experience of the Indigenous peoples in whose territories he lived and died. In this comprehensive and collaborative account, scientific analysis and cultural knowledge interweave to describe a life that ended just as Europeans were about to arrive in the northwest. What emerges is not only a portrait of an individual and his world, but also a model for how diverse ways of knowing, in both scholarly and oral traditions, can complement each other to provide a new understanding of our complex histories.

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Can scientists and engineers replicate Nature and develop systems that operate in extreme environments? Bio-inspiration is an established concept which is developing to meet the needs of the many challenges we face particularly in defence and security. This book explores the potential of bio-inspired materials and sensing systems together with examples of how they are being implemented. It is not an exhaustive study of the subject but provides an overview of how bio-inspired or -derived approaches can be used to enhance components, systems and systems of systems for defence and security applications. Readers will gain an awareness of the complexity and versatility of bio-inspired components as well as an understanding of how these technologies can be applied in a variety of operational scenarios. Consideration is given to using a conceptual model that can be deployed in distributed or autonomous operations. Using this model, bio-inspiration with behavioural science plays a major role in identification, movement, searching strategies and pattern recognition for chemical and biological detection. Examples focus on both learning new things from nature that have application to the defence and security areas and adapting known discoveries for practical use by these communities. This graduate level monograph provides an increased awareness of the need for more sophisticated, networked sensors and systems in the defence and security communities and will be of interest to both specialists in this area and science and technology generalists.

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The Handbook of Chalcogen Chemistry: New Perspectives in Sulfur, Selenium and Tellurium provides an overview of recent developments, particularly from the last decade, on the chemistry of the chalcogen group elements (S, Se and Te). While up to a few decades ago, chalcogen chemistry was mainly centred on sulphur, in recent years the research based on Se and Te has increased dramatically, and has created huge scope for the use of compounds based on this type of chemistry. The Handbook is organised into two parts, the first of which deals systematically with the chemistry of chalcogens in relation to other group elements in the periodic table. It also includes an overview of metal-chalcogenides and metal-polychalcogenides. The second part reflects the interdisciplinary nature of chalcogen chemistry and focuses on biological, materials and supramolecular aspects of the field. This Handbook gives a comprehensive overview on recent developments over the last decade and is ideal for researchers in the field.

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Understanding how simple molecules have given rise to the complex biochemical systems and processes of contemporary biology is widely regarded as one of chemistry’s great unsolved questions. There are numerous theories as to the origins of life, the majority of which draw on the idea that DNA and nucleic acids are the central dogma of biology. The Singularity of Nature: A Convergence of Biology, Chemistry and Physics takes a systems-based approach to the origin and evolution of complex life. Readers will gain a novel understanding of physiologic evolution and the limits to our current understanding: why biology remains descriptive and non-predictive, as well as offering new opportunities for understanding relationships between physics and biology in the origins of biological life at the cellular-molecular level.

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Nanotubes (both of carbon and inorganic materials) can be made in a variety of ways, demonstrating a wide range of fascinating properties. Many of these, such as high mechanical strength and interesting electronic properties relate directly to potential applications. Nanowires have been made from a vast array of inorganic materials and provide great scope for further research into their properties and possible applications. Chapters in this book systematically describe the fundamentals and applications of nanotubes and nanowires, providing a comprehensive and up-to-date survey of the research area, including synthesis, characterisation, properties and applications. This new edition of Nanotubes and Nanowires includes an extensive list of references and is ideal both for graduates needing an introduction to the field of nanomaterials as well as for professionals and researchers in academia and industry. Review of Nanotubes and Nanowires 1st Edition: "This book does a truly admirable job of summarizing the literature in this rapidly changing field." Journal of the American Chemical Society, 2006, 128, 4163-4164 Review of Nanotubes and Nanowires 2nd Edition: "Rao and Govindaraj do a superb job of distilling the huge literature on inorganic nanotubes and nanowires." Chemistry & Industry, 2011, 24, 27

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Fatty alcohols are mainly used in the production of detergents and surfactants. They are also components of cosmetics, foods and as industrial solvents. The 2008 edition originated from a multi-year review of the occurrence, behaviour and use of fatty alcohols to inform the registration of such chemicals through the REACH process in the EU. This review highlighted areas requiring further research. In this expanded edition, new information regarding products containing fatty alcohol derivatives, the fate of these down-the-drain products in wastewater systems and the use of compound specific stable isotope methods has been published. This work has been amalgamated with a number of aspects relating to the inclusion of these compounds in the EU bio-based economy drive. Significant advances have been made since the first edition. No other book brings together all the disparate information regarding this group of chemicals that are of great interest to environmental scientist (as biomarkers), industry (as surfactants) and to regulators.

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Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning. Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques.

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This book pursues possible strategies for synthesising mainly organic compounds, particularly those of interest to the health sector and related industries. Topics covered include addition reactions of aldehydes and ketones; the use of organometallic reagents to form carbon-carbon bonds (eg Grignard reagents); and radical reactions, including selectivity and chain reactions. Retrosynthetic analysis is introduced as a strategy for developing syntheses, along with biochemical pathways. Mechanism and Synthesis concludes with a Case Study on polymers, which demonstrates how chain reactions can be used to build up useful materials with specific properties, such as contact lenses. The Molecular World series provides an integrated introduction to all branches of chemistry for both students wishing to specialise and those wishing to gain a broad understanding of chemistry and its relevance to the everyday world and to other areas of science. The books, with their Case Studies and accompanying multi-media interactive CD-ROMs, will also provide valuable resource material for teachers and lecturers. (The CD-ROMs are designed for use on a PC running Windows 95, 98, ME or 2000.)

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This new historical atlas of Cork will explore the city from its origins to the present day. The emergence of Cork from a monastic settlement on a marshland site through to the thriving city we know today is explained in a thoroughly researched text, illustrated with newly created thematic maps, early views and photographs. Historic maps are reproduced on large-format pages showing how the topography transformed through time. A gazetteer of over 13,000 sites and accompanying essay gives the detailed topographical history of the city up to c. 1900. The Irish Historic Towns Atlas is a long-term research project of the Royal Irish Academy. Since publication began in 1986, thirty atlases of Irish towns and cities, north and south, have been published. The atlases are produced following basic principles making it possible to compare and contrast places with one another. Cork will join the cities of Dublin, Belfast, Galway and Limerick; and regional towns of Bandon and Youghal already cove

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England has more ancient native oak trees than the rest of Europe combined. How did that come about? The reasons are all historical, and nothing to do with climate or soil factors. This story goes back to the Norman conquest of England in 1066. They created Royal Forests, chases and deer parks, where only the nobility could hunt or keep deer and it was forbidden to cut the trees. This was, if you like, an early form of nature conservation, but for the sake of privileged hunting. Preservation of these oaks further continued through a combination of private ownership of thousands of parks, conservatism of the landowners, overseas timber availability and the absence of ruining wars on the English landscape; the majority of which had been confined to the continent. Modernisation of forestry in England only took hold after 1920, and by that stage too late to destroy all of the old and worthless hollow trees. In contrast, modern forestry was introduced on the continent at least 200 years earlier, with devastating results for ancient trees. We owe the ancient oaks to all these circumstances which created a unique ‘population’ of ancient oaks, highly important for biodiversity and an asset unique to England.

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This anthology collates 16 unique and powerful perspectives from occupational therapists around the globe, each highlighting the culture that they are a part of and how it informs their work and care. Ranging across almost every continent in the world including stories from Aotearoa to the Gaza Strip to Dhaka and beyond, Occupational Therapy Disruptors offers a decolonised re-examination of occupational therapy through a poignant, global lens.Based on a series of interviews conducted by Sheela Roy Ivlev, each account provides candid and personal reflections and challenges found in occupational therapy in different cultural and political contexts and inspires occupational therapists to enrich their own practice with cultural awareness and reflexivity.With reflection prompts and calls to action at the end of each chapter, this is an invaluable resource for occupational therapists looking to develop a more diverse, culturally-informed understanding of their practice.

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The three-dimensional aspects of molecular shape can be crucial to both properties and reactions. The Third Dimension explores the arrangements of atoms in molecules and in different types of solids. Initial chapters describe the common crystal structures and how they are related to close-packed arrangements of ions. Metallic, ionic, molecular and extended covalent crystals are covered; major types of crystal defects are also discussed. The book then introduces isomerism, and explores the stereochemical consequences of the tetrahedral carbon atom. Chirality is also investigated. The book concludes with a Case Study on Liquid Crystals, which describes structures, properties and applications. As visualisation in 3D is an important part of this book, the accompanying CD-ROMs provide video material, interactive questions and exercises using models to aid understanding of crystals, organic molecules and stereochemistry. All necessary programs are provided. The Molecular World series provides an integrated introduction to all branches of chemistry for both students wishing to specialise and those wishing to gain a broad understanding of chemistry and its relevance to the everyday world and to other areas of science. The books, with their Case Studies and accompanying multi-media interactive CD-ROMs, will also provide valuable resource material for teachers and lecturers. (The CD-ROMs are designed for use on a PC running Windows 95, 98, ME or 2000.)

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Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects. This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles). Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance. This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS.

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In recent years bioprocessing has increased in popularity and importance, however, bioprocessing still poses various important techno-economic and environmental challenges, such as product yields, excessive energy consumption for separations in highly watery systems, batch operation or the downstream processing bottlenecks in the production of biopharmaceutical products. Many of those challenges can be addressed by application of different process intensification technologies discussed in the present book. The first book dedicated entirely to this area, Intensification of Biobased Processes provides a comprehensive overview of modern process intensification technologies used in bioprocessing. The book focusses on four different categories of biobased products: bio-fuels and platform chemicals; cosmeceuticals; food products; and polymers and advanced materials. It will cover various intensification aspects of the processes concerned, including (bio)reactor intensification; intensification of separation, recovery and formulation operations; and process integration. This is an invaluable source of information for researchers and industrialists working in chemical engineering, biotechnology and process engineering.

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The Franco-Swiss photographer Hélène Binet (b. 1959) is renowned for making images that express an intimate experience of architecture. Using a combination of analogue and digital techniques, her photographs are both a representation and a discovery of her subjects, all of them buildings that break the mould, pushing daringly at the boundaries of their time. In this selection of some ninety of her photographs – ranging from the baroque London churches of Nicholas Hawksmoor and the Jantar Mantar Observatory in Jaipur through to buildings of contemporary architects Le Corbusier, Peter Zumthor, John Hejduk, Daniel Libeskind and Zaha Hadid – her work is revealed in all its subtlety and quiet sensitivity.

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The manipulation of cells and microparticles within microfluidic systems using external forces is valuable for many microscale analytical and bioanalytical applications. Acoustofluidics is the ultrasound-based external forcing of microparticles with microfluidic systems. It has gained much interest because it allows for the simple label-free separation of microparticles based on their mechanical properties without affecting the microparticles themselves. Microscale Acoustofluidics provides an introduction to the field providing the background to the fundamental physics including chapters on governing equations in microfluidics and perturbation theory and ultrasound resonances, acoustic radiation force on small particles, continuum mechanics for ultrasonic particle manipulation, and piezoelectricity and application to the excitation of acoustic fields for ultrasonic particle manipulation. The book also provides information on the design and characterization of ultrasonic particle manipulation devices as well as applications in acoustic trapping and immunoassays. Written by leading experts in the field, the book will appeal to postgraduate students and researchers interested in microfluidics and lab-on-a-chip applications.

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Nanoscale materials and structures have attracted great attention in recent years because of their unique physical and chemical properties and potential use in energy transport and conversion. This book puts the subject into context by first looking at current synthesis methods for nanomaterials, from the bottom-up and top-down methods, followed by enhanced energy conversion efficiency at the nanoscale and then specific applications e.g. photovoltaic cells and nanogenerators. This authoritative and comprehensive book will be of interest to both the existing scientific community in this field, as well as for new people who wish to enter it.

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From crystal structure prediction to totally empirical screening, the quest for new crystal forms has become one of the most challenging issues in the solid state science and particularly in the pharmaceutical world. In this context, multi-component crystalline materials like co-crystals have received renewed interest as they offer the prospect of optimized physical properties. As illustrated in this first book_ entirely dedicated to this emerging class of pharmaceutical compounds_ the outcome of such endeavours into crystal engineering have demonstrated clear impacts on production, marketing and intellectual property protection of active pharmaceutical ingredients (APIs). Indeed, co-crystallization influences relevant physico-chemical parameters (such as solubility, dissolution rate, chemical stability, melting point, hygroscopicity, à) and often offers solids with properties superior to those of the free drug. Combining both reports of the latest research and comprehensive overviews of basic principles, with contributions from selected experts in both academia and industry, this unique book is an essential reference, ideal for pharmaceutical development scientists and graduate students in pharmaceutical science.

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Mass spectrometry is one of the most versatile analytical techniques due to the vast range of analytes that it can detect and quantify and, as such, for its contribution to a significant number of life science fields. The legal and forensics community has certainly benefited from this technique, which has been able to provide reliable evidence in court cases. Liquid Chromatography/Gas Chromatography–Mass Spectrometry (LC/GC–MS) still have a dominant role in the provision of forensic intelligence. However, in the past decade new and exciting MS-based techniques have emerged and are or have evolved to be at an operational deployment maturity, enabling either fast, ambient, non-destructive, or portable screening (or encompass all of these features). In this book, developments of LC–MS and GC–MS based techniques are covered with respect to operational practice and new applications, accompanied by other MS-based techniques that are increasing forensic opportunities and that operate on a variety of evidence types. Whilst the underpinning working principles of each relevant mass spectrometry technique are summarised, each chapter primarily focuses on its implementation in criminal investigation and court cases. In the last chapters, this book additionally covers emerging MS technologies that are at the beginning of their operational implementation journey as well as niche applications outside the fields of traditional forensic science but with a clear potential to impact future investigations (forensics beyond the courtroom). This book provides an up-to-date reference for the mass spectrometry-based tools that are currently available both as established and as emerging methods within forensic practice. It will help casework commissioning managers and forensic providers worldwide to make more informed decisions as to the forensic strategy and workflow when examining exhibits. It is also recommended to postgraduates and early career investigators with reference to the contribution that these techniques and methods could make if applied to classic forensic science practice.

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The agri-food industry creates a vast amount of waste each year. This is not just a problem for waste management, in terms of finding space to store waste and preventing escape of harmful waste into the environment; it also represents a loss of resources: the chemicals and energy which have gone into the production of this waste. If current waste streams can be converted into useful resources this will have multiple benefits by reducing the amount of waste sent to landfill or similar, reducing the need for other feedstocks and removing the pressure from feedstocks that could be used as food. Research into the different types of waste produced by the agri-food industry and approaches to converting them into useful chemicals or chemical feedstocks has advanced rapidly over the last few years. Covering the latest developments in the valorisation of food and agricultural waste, such as valorisation of citrus peel and industrial wastes, this book is a great resource for researchers interested in waste management, sustainability and the circular economy.

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One of the current research lines in analytical chemistry is the design and utilization of novel materials with higher selectivity and improved analytical performance in various steps of chemical analysis. In this sense, Metal–Organic Frameworks (MOFs) have attracted attention as a potential alternative to current commercially available materials. MOFs present an interesting set of properties, such as diverse structural topologies, modifiable pore size, high porosity, tuneable surface area, diverse composition, and versatile functionality. This book covers multipurpose usage MOFs in sample preparation, integration, and detection stages of analytical chemistry. Along with the application of MOFs in green analytical methodologies. It will serve as a reference book for researchers, scientists and engineers who are interested in developing new materials as well as researchers who are interested in new application development.

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The role of carbon dioxide in our changing climate is now hard to ignore, and many countries are making pledges to reduce or eliminate their carbon output. Chemical valorisation of carbon dioxide, as an alternative to sequestration, is likely to play an important part in reaching these targets, and as such is one of the fastest developing areas of green chemistry and chemical reaction engineering. Providing a comprehensive panorama of recent advances in the methods and technologies for chemical valorisation of carbon dioxide, this book is essential reading for anyone with an interest in sustainability and green chemistry. Both the technological improvements in traditional processes and new methods and concepts are discussed, including various (renewable) electricity-based methods, as well as novel catalytic, photocatalytic and biocatalytic approaches.

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Natural products are used by the food, pharmaceutical and cosmetics industries, and extraction technologies and potential applications for plant extracts are of interest to many industrial sectors. Extraction of natural products in an economic and environmentally friendly way is of high importance to all industries involved. The second edition of this book presents an updated, holistic, in-depth view of the more environmentally benign techniques available for the extraction of natural products, along with their newest applications and case studies. Conventional and emerging extraction techniques are discussed in detail. New topics include enzymes, pulsed electric energy, and on-line/in-line analysis. Written for academics and industrialists working in both natural product extraction and green chemistry, this new edition provides a valuable update on current trends in the field.

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The exploration of photothermal nanomaterials with high light-to-heat conversion efficiency has paved the way for practical applications, including in cancer therapy, environmental remediation, catalysis, imaging and biomedicine. Covering the photothermal effect of different categories of light-absorbing nanomaterials, and focusing on metallic nanomaterials, 2D materials, semiconductors, carbon-based nanomaterials, polymeric nanomaterials and their composites, chapters in this book provide a systematic summary of recent advances in the fabrication and application of photothermal nanomaterials, discussing advantages, challenges and potential opportunities. This text will be a valuable resource for scientists working on photothermal nanomaterials, as well as those interested in the applications across chemistry, biomedicine, nanotechnology and materials science.

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Ultrathin metal oxide layers have emerged in recent years as a powerful approach for substantially enhancing the performance of photo, electro, or thermal catalytic systems for energy, in some cases even enabling the use of highly attractive materials previously found unsuitable. This development is due to the confluence of new synthetic preparation methods for ultrathin oxide layers and a more advanced understanding of interfacial phenomena on the nano and atomic scale. This book brings together the fundamentals and applications of ultrathin oxide layers while highlighting connections and future opportunities with the intent of accelerating the use of these materials and techniques for new and emerging applications of catalysis for energy. It comprehensively covers the state-of-the-art synthetic methods of ultrathin oxide layers, their structural and functional characterization, and the broad range of applications in the field of catalysis for energy. Edited by leaders in the field, and with contributions from global experts, this title will be of interest to graduate students and researchers across materials science and chemistry who are interested in ultrathin oxide layers and their applications in solar energy conversion, renewable energy, photocatalysis, electrocatalysis and protective coatings.

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Porphyrin-based Supramolecular Architectures focuses on the most recent developments in the field, emphasizing the cutting-edge research in a diverse range of applications. Designed for readers considering the unprecedented prosperity of porous materials research, chapters will cover both strategies for structure design (such as MOFs and COFs) as well as emerging applications including CO2 fixation, catalysis and photodynamic therapy. With contributions from global experts, this title will be of interest to graduate students and researchers in supramolecular chemistry, organic chemistry, inorganic chemistry, physical chemistry, organometallic chemistry, solid-state chemistry, catalysis and (porous) materials science.

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Providing the reader with an up to date digest of the most important current research carried out in the field, this volume is compiled and written by leading experts from across the globe. It reviews the trends in electrochemical sensing and its applications and touches on research areas from a diverse range including microbial electrosynthesis for bio-based production using renewable electricity and recent advances in inorganic nanostructured materials for electrochemical water splitting. The reviews of established and current interest in the field make this book a key reference for researchers in this exciting and developing area.

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The extracellular matrix (ECM) supports cells and regulates various cellular functions in our body. The native ECM promises to provide an excellent scaffold for regenerative medicine. In order to use the ECM as a scaffold in medicine, its cellular fractions need to be removed while retaining its structural and compositional properties. This process is called decellularization, and the resulting product is known as the decellularized extracellular matrix (dECM). This book focuses on the sources of dECM and its preparation, characterization techniques, fabrication, and applications in regenerative medicine and biological studies. Using this book, the reader will gain a good foundation in the field of ECM decellularization complemented with a broad overview of dECM characterization, ranging from structural observation and compositional assessment to immune responses against dECM and applications, ranging from microfabrication and 3D-printing to the application of tissue-derived dECM in vascular grafts and corneal tissue engineering etc. The book closes with a section dedicated to cultured cell dECM, a complementary technique of tissue-derived dECM preparation, for application in tissue engineering and regenerative medicine, addressing its use in stem cell differentiation and how it can help in the study of the tumor microenvironment as well as in clinical trials of peripheral nerve regeneration.

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Currently the majority of carbon-based feedstocks come from fossil fuels of which there is a finite supply. Methane is an abundantly available carbon-based feedstock, with large amounts now available through fracking and renewable sources available from biogas plants. However, methane is not very chemically reactive. One of the remaining “grand challenges” in chemistry is the development of clean, efficient, affordable processes that allow methane to be converted to other high value molecules. Highlighting the recent advances in methane activation and direct conversion processes this book discusses the progress and current state of the art for a wide variety of alternative methane activation and subsequent conversion processes, including homogeneous- and heterogeneous catalytic, electrocatalytic and pyrolytic systems. It is a useful resource for anyone working in green chemistry, catalysis and chemical engineering.

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Nanoparticles have numerous biomedical applications including drug delivery, bone implants and imaging. A protein corona is formed when proteins existing in a biological system cover the nanoparticle surface. The formation of a nanoparticle–protein corona, changes the behaviour of the nanoparticle, resulting in new biological characteristics and influencing the circulation lifetime, accumulation, toxicity, cellular uptake and agglomeration. This book provides a detailed understanding of nanoparticle–protein corona formation, its biological significance and the factors that govern the formation of coronas. It also explains the impact of nanoparticle–protein interactions on biological assays, ecotoxicity studies and proteomics research. It will be of interest to researchers studying the application of nanoparticles as well as toxicologists and pharmaceutical chemists.

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The synergy between synthetic biology and biocatalysis is emerging as an important trend for future sustainable processes. This book reviews all modern and novel techniques successfully implemented in biocatalysis, in an effort to provide better performing enzymatic systems and novel biosynthetic routes to (non-)natural products. This includes the use of molecular techniques in protein design and engineering, construction of artificial metabolic pathways, and application of computational methods for enzyme discovery and design. Stress is placed on current ‘hot’ topics in biocatalysis, where recent advances in research are defining new grounds in enzyme-catalyzed processes. With contributions from leading academics around the world, this book makes a ground-breaking contribution to this progressive field and is essential reading for graduates and researchers investigating (bio)catalysis, enzyme engineering, chemical biology, and synthetic biology.

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Concerns about the adverse effects of chemicals present in the environment have created a need for better systems to assess their potential consequences on human health. One potential solution is the versatile and state-of-the-art Comet assay. Simple, sensitive, rapid and visual, this modern toxicological method allows quantitative and qualitative assessment of DNA damage in single cells. This assay is used in diverse fields ranging from clinical applications, human monitoring and environmental toxicology through to genetic toxicity testing. This updated and revised edition of The Comet Assay in Toxicology provides the latest information on this important tool. It addresses, in-depth, the different protocols, statistical analyses and applications used worldwide. It also includes the guidelines recommended by the Working Group on Comet Assay. The book begins with a review of the genesis of the assay for those new to the technique and goes on to explain procedures followed to assess different types of DNA damage, various applications of the assay, and guidelines for the conduct of the assay in in vitro and in vivo systems. New chapters written for this edition will provide information on the most contemporary approaches and applications, including in silico approaches, on meta-analysis of data and on the application of the Comet Assay in nanotoxicology. This book will serve as both a reference and a guide to students as well as investigators in the biomedical, biochemical and pharmaceutical sciences fields.

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