Search results for ""author roy"

New genomic information has revealed the crucial role that protein–protein interactions (PPIs) play in regulating numerous cellular functions. Aberrant forms of these interactions are common in numerous diseases and thus PPIs have emerged as a vast class of critical drug targets. Despite the importance of PPIs in biology, it has been extremely challenging to convert targets into therapeutics and targeting PPIs had long been considered a very difficult task. However, over the past decade the field has advanced with increasing growth in the number of successful PPI regulators. Protein–Protein Interaction Regulators surveys the latest advances in the structural understanding of PPIs as well as recent developments in modulator discovery.

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Three brand new adventures featuring Christopher Eccleston as the Ninth Doctor. Travelling the universe alone, the Doctor can't help running into people. Some are new acquaintances, and some have a much longer history, back through all of his lives. But every one of them knows that in the face of danger, and when the monsters arrive, there's no better friend to have by their side. 4.1 Fond Farewell by David K Barnes. Fond Farewell is the intergalactic funeral parlour with a difference: the deceased attend their own wake! Invited by celebrated naturalist Flynn Beckett to his memorial, the Doctor finds he's not quite the man he was. But who would steal the memories of the dead? 4.2 Way of the Burryman by Roy Gill. Young Sam Bishop is at a crossroads with girlfriend Fiona: she's staying in Scotland, he wants to travel the world. As the Burryman celebrations begin, ghosts haunt the Forth Bridge. Brigadier Lethbridge-Stewart arrives to investigate - and so does the Doctor... 4.3 The Forth Generation by Roy Gill. The Forth Generation have emerged. The Doctor, the Brigadier, Sam and Fiona are at their mercy. Is there a way to defeat them? Has UNIT learned from the past? And can the enemy's nature be changed for the future? Cast: Christopher Eccleston (The Doctor), Jon Culshaw (Brigadier Lethbridge-Stewart), Warren Brown (Sam Bishop), Elinor Lawless (Fiona McCall) Alexander Cobb (Foreman/UNIT Courier/Sergeant Lowe), James Doherty (Professor Flynn Beckett/Other Flynn), Amanda Drew (Commander Jane Wardie), Sienna Guillory (Idara Beckett), Charlie Hamblett (Thomas/Attendants), Martin Quinn (Cameron Lawther), Juliet Stevenson (Winifred Whitby), Emily Taaffe (Sasha Yan), Nicholas Briggs (The Cybermen). Other parts played by members of the cast.

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From "the Kid" on the Varsity Blues football team to "the Chief" at Osgoode Hall, R. Roy McMurtry has had a remarkably varied and influential career. As reformist attorney general of Ontario, one of the architects of the agreement that brought about the patriation of the Canadian Constitution, high commissioner to the United Kingdom, and chief justice of Ontario, he made a large and enduring contribution to Canadian law, politics, and life. These memoirs cover all these facets of his remarkable career, as well as his law practice, his work on various commissions of inquiry, and his reflections on family, sport, and art. This volume is both an account of his life in public service and a portrait of a humane, humorous, still optimistic, and always decent man.

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Christopher Eccleston makes his long-awaited, much-anticipated debut with Big Finish as the Ninth Doctor, in this limited vinyl edition set containing three new stories. Travelling the universe alone, the Doctor can’t help running into people. Some are new acquaintances, and some have a much longer history, back through all of his lives. But every one of them knows that in the face of danger, and when the monsters arrive, there’s no better friend to have by their side. 4.1 Fond Farewell by David K Barnes. Fond Farewell is the intergalactic funeral parlour with a difference: the deceased attend their own wake! Invited by celebrated naturalist Flynn Beckett to his memorial, the Doctor finds he’s not quite the man he was. But who would steal the memories of the dead? 4.2 Way of the Burryman by Roy Gill. Young Sam Bishop is at a crossroads with girlfriend Fiona: she’s staying in Scotland, he wants to travel the world. As the Burryman celebrations begin, ghosts haunt the Forth Bridge. Brigadier Lethbridge-Stewart arrives to investigate – and so does the Doctor… 4.3 The Forth Generation by Roy Gill. The Forth Generation have emerged. The Doctor, the Brigadier, Sam and Fiona are at their mercy. Is there a way to defeat them? Has UNIT learned from the past? And can the enemy’s nature be changed for the future? CAST: Christopher Eccleston (The Doctor), Jon Culshaw (Brigadier Lethbridge-Stewart), Warren Brown (Sam Bishop), Elinor Lawless (Fiona McCall) Alexander Cobb (Foreman/UNIT Courier/Sergeant Lowe), James Doherty (Professor Flynn Beckett/Other Flynn), Amanda Drew (Commander Jane Wardie), Sienna Guillory (Idara Beckett), Charlie Hamblett (Thomas/Attendants), Martin Quinn (Cameron Lawther), Juliet Stevenson (Winifred Whitby), Emily Taaffe (Sasha Yan), Nicholas Briggs (The Cybermen). Other parts played by members of the cast.

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Serial winners and glorious losers, heroes and villains, trailblazing women, role models and rogues, all are here; so too are audacious sporting founders, enduring legends and forgotten or overlooked greats. Through a selection of sixty lives from the Dictionary of Irish Biography, this book celebrates the diversity of Irish sporting history. The Dictionary of Irish Biography is a project of the Royal Irish Academy. It tells the island’s life story through the biographies, at home and overseas, of prominent men and women born in Ireland, north and south, and the noteworthy Irish careers of those born outside Ireland. The online edition of the Dictionary of Irish Biography now features nearly 11,000 lives and continues to grow. dib.ie

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An abduction in London and the discovery of a body on the west coast of Sweden lead criminal profiler Emily Roys and true-crime writer Alexis Castells back to Jack the Ripper’s Whitechapel, as they hunt a serial killer. Book two in the explosive, award-winning Roy & Castells series. ‘A terrific, original duo’ Marcel Berlins, The Times ‘Gritty, bone-chilling, and harrowing – it’s not for the faint of heart, and not to be missed’ Crime by the Book ‘A relentless heart-stopping masterpiece, filled with nightmarish situations that will keep you awake long into the dark nights of winter’ New York Journal of Books ___________________Whitechapel, 1888: London is bowed under Jack the Ripper’s reign of terror.London 2015: Actress Julianne Bell is abducted in a case similar to the terrible Tower Hamlets murders of some ten years earlier, and harking back to the Ripper killings of a century before.Falkenberg, Sweden, 2015: A woman’s body is found mutilated in a forest, her wounds identical to those of the Tower Hamlets victims. With the man arrested for the Tower Hamlets crimes already locked up, do the new killings mean he has a dangerous accomplice, or is a copy-cat serial killer on the loose? Profiler Emily Roy and true-crime writer Alexis Castells again find themselves drawn into an intriguing case, with personal links that turn their world upside down. Following the highly acclaimed Block 46 and guaranteed to disturb and enthral, Keeper is a breathless thriller from the new queen of French Noir. ___________________ ‘A bold and intelligent read’ Guardian ‘A satisfying, full-fat mystery’ The Times ‘Assured telling of a complex story’ Sunday Times ‘Dark, oppressive and bloody but also thought-provoking, compelling and very moving’ Metro ‘A real page-turner, I loved it’ Martina Cole ‘Cleverly plotted, simply excellent’ Ragnar Jónasson ‘A must-read’ Daily Express ‘Gustawsson’s writing is so vivid, it’s electrifying. Utterly compelling’ Peter James ‘Bold and audacious’ R. J. Ellory ‘A great serial-killer thriller with a nice twist … first rate’ James Oswald ‘Thought-provoking, challenging, and an absolute knock-out … I’m still in shock’ LoveReading ‘A great addition to the world of noir novels, and lives alongside the best...’ TripFiction

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Providing up-to-date coverage of green nanomaterials and systems, this book provides comprehensive information on nanostructured materials, including their applications in energy and environmental sciences. The book focusses on photo-active nanostructured materials, from the basic understanding of solar energy activation to their sustainable preparation and applications in environmental remediation and fuel production from biomass and carbon dioxide. It also examines the health and environmental impacts of photo-catalyst nanomaterials. This book is an important reference for researchers and industrial chemists working in the fields of energy and environmental remediation.

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Dendrimers are important molecules that are currently undergoing investigation for use in a variety of different biomedical applications. This book explores the use of dendrimers for a variety of potential functions, including antiamyloidogenic agents, drug delivery systems, nucleic acid and RNA delivery vectors and to produce hybrid fibre platforms for nantechnology. Following the work of COST action TD0802, the main objective of which is to improve existing therapies and find new drugs based on dendrimers, the book will provide comprehensive coverage of dendrimer applications. Coverage includes modelling and molecular dynamic studies of dendrimers and dendrons, anionic dendrimer polymers, cationic carbosilane dendrimers and self-assembled multivalent dendrimers. Providing clear indications for future research and applications, this text will appeal to chemists, biologists and materials scientists, working in both academia and industry.

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Isoflavones remain the subject of many scientific studies most of which reveal them to have some health benefits. Coverage within this book begins with an overview of phytoestrogens in health and plants with specific reference to isoflavones, how isoflavones are found in the diet and novel compounds in nuts. Expert accounts of the chemical and biochemical research on this topic are provided followed by analytical and bioanalytical assessments. Rounding up the book are the chapters on function and effects of isoflavones which provide details on isoflavones in beverages, soy and soy products and other food delivery systems and how their function effects the thyroid, menopause, prostate, breast, bone and cardiovascular disease to name but a few. Delivering high quality information, this extensive and detailed book provides a fascinating insight into this area of health and nutritional science. It will bridge scientific disciplines so that the information is more meaningful and applicable to health in general. Part of a series of books, it is specifically designed for chemists, analytical scientists, forensic scientists, food scientists, dieticians and health care workers, nutritionists, toxicologists and research academics. Due to its interdisciplinary nature it could also be suitable for lecturers and teachers in food and nutritional sciences and as a college or university library reference guide.

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The Ghanian plant Cryptolepis sanguinolenta is the source of a series of fascinating indoloquinoline alkaloids. The most unusual member of this alkaloid series was initially proposed to be a spiro nonacyclic structure, named cryptospirolepine, and was elucidated in 1993 based on the technologies available at that time. There were, however, several annoying attributes to the structure that bothered analysts for the ensuing 22 years. During the two decades that followed the initial work there have been enormous developments in NMR technology. Using new experimental approaches, specifically homodecoupled 1,1- and 1,n-HD-ADEQUATE NMR experiments developed in 2014, the structure of only a 700 µg sample of cryptospirolepine has been revised and is shown on the cover of this volume. The confluence of the NMR technological and methodological advances that allowed the revision of the structure of cryptospirolepine using a submilligram sample seems a fitting example for this book, which is dedicated to the NMR characterization of various classes of natural products. Volume 2 considers data processing and algorithmic based analyses tailored to natural product structure elucidation and reviews the application of NMR to the analysis of a series of different natural product families including marine natural products, terpenes, steroids, alkaloids and carbohydrates. Volume 1 discusses contemporary NMR approaches including optimized and future hardware and experimental approaches to obtain both the highest quality and most appropriate spectral data for analysis. These books, bringing together acknowledged experts, uniquely focus on the combination of experimental approaches and modern hardware and software applied to the structure elucidation of natural products. The volumes will be an essential resource for NMR spectroscopists, natural product chemists and industrial researchers working on natural product analysis or the characterization of impurities and degradation products of pharmaceuticals that can be as scarce as natural product samples.

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Strychnine’s poisonous nature was known in 16th century Europe, and the alkaloid was isolated in pure form for the first time in 1818. Then began a more than century-long quest to unravel the structure of strychnine that led to two Nobel prizes, clearly without the assistance of the modern spectroscopic methods to which we now have access. In his 1963 report of the synthesis, Woodward said, "The tangled skein of atoms which constitutes its molecule provided a fascinating structural problem that was pursued intensively during the century just past, and was solved finally only within the last decade." The structure elucidation of complex natural products is facilitated today by access to modern instrumentation and experimental techniques. Using a modern 600 MHz NMR spectrometer equipped with a 1.7 mm cryogenic probe and a 1 mg sample, it is now possible to acquire a comprehensive suite of 2D NMR spectra that rigorously characterizes the complex structure of strychnine in a scant 24 hours. When the 2D NMR data are combined with Computer-Assisted Structure Elucidation methods, the structure can be solved in mere seconds. It is against this historical backdrop that these two volumes regarding the Structure Elucidation of Natural Products by NMR is set. Volume 1 discusses contemporary NMR approaches including optimized and future hardware and experimental approaches to obtain both the highest quality and most appropriate spectral data for analysis. Volume 2 considers data processing and algorithmic based analyses tailored to natural product structure elucidation and reviews the application of NMR to the analysis of a series of different natural product families including marine natural products, terpenes, steroids, and carbohydrates. These books, bringing together acknowledged experts, uniquely focus on the combination of experimental approaches and modern hardware and software applied to the structure elucidation of natural products. The volumes will be an essential resource for NMR spectroscopists, natural product chemists and industrial researchers working on natural product analysis or the characterization of impurities and degradation products of pharmaceuticals that can be scarce as natural product samples.

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Dementia and neurodegenerative diseases such as Parkinson’s and Alzheimer’s are becoming an increasingly important cause of medical and social concern due to the growth in the ageing population. Mechanisms and Metal Involvement in Neurodegenerative Diseases delivers in one volume a streamlined source of information on each of the main neurodegenerative diseases including mild cognitive impairment, Parkinson's, Alzheimer's, Freiderich's ataxia, prion disease, multiple sclerosis and alcoholic brain damage. Each chapter is structured to give the definition of disease, proteins involved with structure of normal protein and abnormal proteins, pathology associated with the abnormal proteins, oxidative stress and inflammation, iron homeostatic mechanisms, primary neurotransmitter involved, other metal involvement and therapeutic strategies. Structures of the adherent protein involved in the disease process are also presented with emphasis on the chemical structures used in the treatment of each neurodegenerative disease together with their biochemical mode of action. Written by acknowledged experts in their respective areas this new book provides readers with readily accessible information on each of the neurodegenerative diseases.

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Controlled/living radical polymerization (CRP) has revolutionized and revitalized the field of synthetic polymer chemistry over the last twenty years as it is now possible to prepare a wide variety of previously inaccessible macromolecules under relatively mild conditions. Fundamentals of Controlled/Living Radical Polymerization provides an in-depth coverage of the essential chemical principles that enable and govern each of the CRP methods. The book starts with a brief historical overview of the major findings in polymer science which eventually led to the development of living ionic and living radical systems. It then goes on to introduce the main CRP techniques including their mechanistic understanding. The book also provides the information needed to select the appropriate reagents and conditions to conduct various CRP methods in a practical setting. Therefore, in addition to a newcomer gaining an appreciation for what has already been accomplished, the reader will be armed with the tools needed to begin independent research. Fundamentals of Controlled/Living Radical Polymerization provides essential insight into a rapidly growing field that goes beyond a simple literature review of the area. Written by leading experts in the field, the book is an indispensible resource for all researchers, instructors, and students in polymer chemistry.

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The ultra-bright femtosecond X-ray pulses provided by X-ray free electron lasers (XFELs) open up opportunities to study the structure and dynamics of a wide variety of systems beyond what is possible with synchrotron sources. This book introduces the principles and properties of currently operating and future XFELs, before outlining applications in materials science, chemistry and biology. Edited by pioneers in this exciting field, and featuring contributions from leading researchers, this book is ideal for researchers working with XFELs, synchrotron radiation, ultrafast and femtosecond crystallography and femtosecond spectroscopy.

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Ayurvedic Medicine, or Ayurveda, is a traditional Indian health care system. Research into the medicinal plants utilised in Ayurveda is becoming a global endeavour, and large pharmaceutical companies are investing in novel drug discovery from Ayurvedic sources as a number of clinical studies have demonstrated efficacy of natural products from Ayurvedic plant extracts against common ailments such as arthritis and diabetes. Ayurvedic medicine and its components have been well described in the past, but this book represents a comprehensive source on the biochemistry and mechanisms of the pharmacological effects of natural products from Ayurvedic sources. This book is a valuable resource for researchers in natural products and alternative sources of bioactive compounds in drug discovery, as well as pharmaceutical experts and those in industry.

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Many projects in recent years have applied context-based learning and engagement tools to the fostering of long-term student engagement with chemistry. While empirical evidence shows the positive effects of context-based learning approaches on students’ interest, the long-term effects on student engagement have not been sufficiently highlighted up to now. Edited by respected chemistry education researchers, and with contributions from practitioners across the world, Engaging Learners with Chemistry sets out the approaches that have been successfully tested and implemented according to different criteria, including informative, interactive, and participatory engagement, while also considering citizenship and career perspectives. Bringing together the latest research in one volume, this book will be useful for chemistry teachers, researchers in chemistry education and professionals in the chemical industry seeking to attract students to careers in the chemical sector.

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The considerable interest in graphene and 2D materials is sparking intense research on layered materials due to their unexpected physical, electronic, chemical, and optical properties. This book will provide a comprehensive overview of the recent and state-of-the-art research progress on layered materials for energy storage and other applications. With a brief introduction to layered materials, the chapters of this book gather various fascinating topics such as electrocatalysis for fuel cells, lithium-ion batteries, sodium-ion batteries, photovoltaic devices, thermoelectric devices, supercapacitors and water splitting. Unique aspects of layered materials in these fields, including novel synthesis and functionalization methods, particular physicochemical properties and consequently enhanced performance are addressed. Challenges and perspectives for layered materials in these fields will also be presented. With contributions from key researchers, Layered Materials for Energy Storage and Conversion will be of interest to students, researchers and engineers worldwide who want a basic overview of the latest progress and future directions.

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To thrive, every living cell must continuously gauge and respond to changes in its environment. These changes are ultimately implemented by modulating gene expression, a process that relies on transcription by Nature’s most multivalent molecular machine, the RNA polymerase. This book covers progress made over the past decade understanding how this machine functions to compute the cellular state, from the atomistic structural level responsible for chemistry to the integrative level at which RNA polymerase interacts with the other key molecular machineries of the cell.

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The most useful properties of food, i.e. the ones that are detected through look, touch and taste, are a manifestation of the food’s structure. Studies about how this structure develops or can be manipulated during food production and processing are a vital part of research in food science. This book provides the status of research on food structure and how it develops through the interplay between processing routes and formulation elements. It covers food structure development across a range of food settings and consider how this alters in order to design food with specific functionalities and performance. Food structure has to be considered across a range of length scales and the book includes a section focusing on analytical and theoretical approaches that can be taken to analyse/characterise food structure from the nano- to the macro-scale. The book concludes by outlining the main challenges arising within the field and the opportunities that these create in terms of establishing or growing future research activities. Edited and written by world class contributors, this book brings the literature up-to-date by detailing how the technology and applications have moved on over the past 10 years. It serves as a reference for researchers in food science and chemistry, food processing and food texture and structure.

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The food supply chain needs to reassure consumers and businesses about the safety and standards of food. Global estimates of the cost of food fraud to economies run into billions of dollars hence a huge surge in interest in food authenticity and means of detecting and preventing food fraud and food crime. Approaches targeting DNA markers have assumed a pre-eminence. This book is the most comprehensive and timely collection of material from those working at the forefront of DNA techniques applied to food authenticity. Addressing the new field of analytical molecular biology as it combines the quality assurance rigour of analytical chemistry with DNA techniques, it introduces the science behind DNA as a target analyte, its extraction, amplification, detection and quantitation as applied to the detection of food fraud and food crime. Making the link with traditional forensic DNA profiling and describing emerging and cutting-edge techniques such as next generation sequencing, this book presents real-world case studies from a wide perspective including from analytical service providers, industry, enforcement agencies and academics. It will appeal to food testing laboratories worldwide, who are just starting to use these techniques and students of molecular biology, food science and food integrity. Food policy professionals and regulatory organisations who will be using these techniques to back up legislation and regulation will find the text invaluable. Those in the food industry in regulatory and technical roles will want to have this book on their desks.

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Synthetic biology combines science and engineering in order to design, build and test novel biological functions and systems. As with any multi-disciplinary field, there is a rapidly-growing body of literature concerning synthetic biology and locating the best information or identifying the hottest topics can be time-consuming. This volume captures the expanding primary literature in the form of critical and comprehensive reviews providing the reader with an authoritative digest of the latest developments in this emerging field. Each chapter strives to highlight the most recent findings in specific sub-areas and reviews research reports that were published over the last two to three years. Leading researchers draw material from both dedicated journals and broader sources, revising traditional concepts in light of emerging discoveries while keeping up with recent progress, making this an essential reference to any library supporting this research.

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The Lammermuir Hills have been an important trade route between Scotland and England for generations, as well as an effective barrier when necessary. Drawn by the long history of south-eastern Scotland and the many conflicting elements in play in its natural environment – among them wind farms, pylons, forestry plantations, grouse moors and sheep – the distinguished Scottish painter and printmaker Barbara Rae CBE RA has made numerous studies of these wild expanses. This handsome volume reproduces a wide selection of her intensely colourful images with accompanying photographs and maps, and texts by the art critic Duncan Macmillan, Emeritus Professor of the History of Scottish Art at the University of Edinburgh, and Maureen Barrie, who worked for many years at National Museums Scotland.

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The new edition of the bestselling book for real estate agents, loan officers, SaaS and small businesses. In this revision, The Conversion Code: A Step-by-Step Guide to Marketing and Sales that Will Grow Your Business Faster, Second Edition, digital marketing and lead conversion expert Chris Smith delivers the ultimate exploration of the marketing and advertising tactics that are successfully generating higher quality leads that are easier for salespeople to convert. Smith researches and tests the latest and most popular platforms, including TikTok, YouTube and Instagram, while also studying the most effective sales techniques, tools, and scripts. In this book, you'll learn to: Increase your lead conversion rate, reduce your cost per lead and improve your overall ROI from marketing and sales Generate an endless supply of high-quality leads from social media that are easy to convert into closed sales Stop chasing leads and start attracting clients with amazing marketing and clever ads Adapt to the consumer privacy changes that have made targeting ads and getting leads to answer the phone harder than ever Differentiate your brand in a way that positions you as the authority and gets people contacting you who are already sold An invaluable reference and easy to follow guide for real estate agents, loan officers, SaaS and small businessescompeting in the hyper-competitive online environment. The Conversion Code, Second Edition, is also a fantastic resource for sales leaders, marketing managers, business owners and anyone else with a team who is responsible for growing revenue.

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Covering the breadth of zeolite chemistry and catalysis, this book provides the reader with a complete introduction to field, covering synthesis, structure, characterisation and applications. Beginning with the history of natural and synthetic zeolites, the reader will learn how zeolite structures are formed, synthetic routes, and experimental and theoretical structure determination techniques. Their industrial applications are covered in-depth, from their use in the petrochemical industry, through to fine chemicals and more specialised clinical applications. Novel zeolite materials are covered, including hierarchical zeolites and two-dimensional zeolites, showcasing modern developments in the field. This book is ideal for newcomers who need to get up to speed with zeolite chemistry, and also experienced researchers who will find this a modern, up-to-date guide.

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Photovoltaic systems enable the sun’s energy to be converted directly into electricity using semiconductor solar cells. The ultimate goal of photovoltaic research and development is to reduce the cost of solar power to reach or even become lower than the cost of electricity generated from fossil and nuclear fuels. The power conversion efficiency and the cost per unit area of the phototvoltaic system are critical factors that determine the cost of photovoltaic electricity. Until recently, the power conversion efficiency of single-junction photovoltaic cells has been limited to approximately 33% - the socalled Shockley-Queisser limit. This book presents the latest developments in photovoltaics which seek to either reach or surpass the Shockley-Queisser limit, and to lower the cell cost per unit area. Progress toward this ultimate goal is presented for the three generations of photovoltaic cells: the 1st generation based on crystalline silicon semiconductors; the 2nd generation based on thin film silicon, compound semiconductors, amorphous silicon, and various mesoscopic structures; and the 3rd generation based on the unique properties of nanoscale materials, new inorganic and organic photoconversion materials, highly efficient multi-junction cells with low cost solar concentration, and novel photovoltaic processes. The extent to which photovoltaic materials and processes can meet the expectations of efficient and cost effective solar energy conversion to electricity is discussed. Written by an international team of expert contributors, and with researchers in academia, national research laboratories, and industry in mind, this book is a comprehensive guide to recent progress in photovoltaics and essential for any library or laboratory in the field.

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The binding of small ligands to biological molecules is central to most aspects of biological function. The past twenty years has seen the development of an increasing armoury of biophysical methods that not only detect such binding, but also provide varying degrees of information about the kinetics, thermodynamics and structural aspects of the process. These methods have received increasing attention with the growth in more rational approaches to drug discovery and design. This book reviews the latest advances in the application of biophysics to the study of ligand binding. It provides a complete overview of current techniques to identify ligands, characterise their binding sites and understand their binding mechanisms. Particular emphasis is given to the combined use of different techniques and their relative strengths and weaknesses. Consistency in the way each technique is described makes it easy for readers to select the most suitable protocol for their research. The introduction explains why some techniques are more suitable than others and emphasizes the possible synergies between them. The following chapters, all written by a specialist in the particular technique, focus on each method individually. The book finishes by describing how several complimentary techniques can be used together for maximum effectiveness. This book is suitable for biomolecular scientists at graduate or post-doctoral level in academia and industry. Biologists and chemists will also find it a useful introduction to the techniques available.

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International interest in nanoscience research has flourished in recent years, as it becomes an integral part in the development of future technologies. The diverse, interdisciplinary nature of nanoscience means effective communication between disciplines is pivotal in the successful utilization of the science. Nanochemistry: A Chemical Approach to Nanomaterials is the first textbook for teaching nanochemistry and adopts an interdisciplinary and comprehensive approach to the subject. It presents a basic chemical strategy for making nanomaterials and describes some of the principles of materials self-assembly over 'all' scales. It demonstrates how nanometre and micrometre scale building blocks (with a wide range of shapes, compositions and surface functionalities) can be coerced through chemistry to organize spontaneously into unprecedented structures, which can serve as tailored functional materials. Suggestions of new ways to tackle research problems and speculations on how to think about assembling the future of nanotechnology are given. Primarily designed for teaching, this book will appeal to graduate and advanced undergraduate students. It is well illustrated with graphical representations of the structure and form of nanomaterials and contains problem sets as well as other pedagogical features such as further reading, case studies and a comprehensive bibliography.

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Chemometrics, or the application of multivariate statistics to chemical data, provides informative and statistically valid analyses within a forensic context and there has been an increase in the use of chemometrics to characterise forensic exhibits. Introducing chemometric methods suitable for forensic practitioners, this book fills a gap in the literature outlining how such methods are applied to forensic casework, what limitations to these approaches exist, and future trends emerging in the field. The book highlights how chemometric methods may be applied to different areas of forensic science, enabling more confident and transparent decision-making based on quantitative approaches. It is divided into various sections which include a background to chemometrics, types of chemometric methods, their applications in various disciplines of forensic science, and emerging trends in the field. The detailed discussion of chemometric methods used for the examination of forensic exhibits outlines their advantages, limitations, and efficiency. Providing a centralised source of information addressing the above aspects, and suitable for forensic practitioners, researchers and stakeholders, this book is written for MSc Forensic Science courses and more broadly applications in the biological, chemical and physical sciences.

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Silk proteins show excellent biocompatibility, controllable biodegradability and non-immunogenicity, and as such are studied extensively worldwide for biomedical applications. In particular, there is increasing interest in their use for drug delivery systems. This focussed book on silk proteins for drug delivery systems, delves into a key emerging area to outline the concepts and define the field. Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin. Showing how these proteins are employed in micro and nano drug delivery systems, their use in pre-clinical and clinical trials, and closing with chapter on sustainability- driven innovation in the pharma industry, this book is ideal for graduates and researchers in biomaterials science and pharmaceutical science.

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Immunosensors are widely used and are particularly important for fast diagnosis of diseases in remote environments as well as point-of-care devices. In this book, expert scientists are covering a selection of high quality representative examples from the past five years explaining how this area has developed. It is a compilation of recent advances in several areas of immunosensors for multiple target analysis using laboratory based or point-of-care set-up, for example graphene-, ISFET- and nanostructure-based immunosensors, electrochemical magneto immunosensors and nanoimprinted immunosensors. Filling a gap in the literature, it showcases the multidisciplinary, innovative developments in this highly important area and provides pointers towards commercialisation. Delivering a single, comprehensive work, it appeals to graduate students and professional researchers across academia and industry.

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Nanogel-based systems have gained tremendous attention due to their diverse range of applications in tissue engineering, regenerative medicine, biosensors, orthopaedics, wound healing and drug delivery. Nanogels for Biomedical Applications provides a comprehensive overview of nanogels and their use in nanomedicine. The book starts with the synthesis, methods and characterization techniques for nanogel-based smart materials followed by individual chapters demonstrating the different uses of the materials. Applications covered include anticancer therapy, tuberculosis diagnosis and treatment, tissue engineering, gene delivery and targeted drug delivery. The book will appeal to biologists, chemists, and nanotechnologists interested in translation research for personalized nanomedicine for health care.

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Polymer science faces the challenge of meeting growing market demand for polymers whilst achieving sustainability through environmentally friendly processes. Microwave heating has emerged as a greener technique that accelerates a variety of chemical reactions, including polymerization. Microwave-assisted reactions can be cleaner and more rapid and economic analyses suggest that the cost of curing polymers may be reduced by switching over to the use of microwaves. This book provides comprehensive coverage of microwave-assisted polymerization. The first chapter introduces readers to the theory behind the accelerating effects of microwaves on chemical reactions and covers the types of commercial microwave reactors being used for synthesis and processing of polymers that are available on the market. Subsequent chapters are organised by type of reaction, including radical homo and co-polymerizations, step growth polymerization and peptide synthesis. Importantly, analysis of processes and product properties in comparison with conventional methods is also detailed. This book will be a valuable resource for green chemists and polymer scientists and engineers who want to develop sustainable processes.

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This second volume chronicles the later stages of the outbreak of SARS-Cov-2 (COVID-19) and delineates the role of several disciplines in therapeutic and control measures highliting the response from specific coutries of note and efforts to repurpose and produce new therapeutics and vaccines. By addressing considerations of efficacy and safety of drugs and chemicals used to combat COVID-19, virtually in real-time, this book documents and highlights the advances in science and place the toxicology, pharmaceutical science, public health and medical community in a better position to advise in future epidemics.

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The Irish struck out across America’s frontiers, built its railroads, fought on both sides of the civil war, captured its major historic moments in print, paint and bronze, led many of its religious denominations, policed its streets, set up its banks, educated its masses, entertained America on its stages and screens and in its sporting arenas, and made ground-breaking contributions in science and engineering. This collection documents fifty Irish people who made an indelible mark on American society, politics and culture. People like the pirate Anne Bonney and Gertrude Brice Kelly, one of New York City's first surgeons, feature alongside more familiar names such as Maureen O'Hara, Maeve Brennan, Rex Ingram and the architect of the White House James Hoban. About the Dictionary of Irish Biography: The Dictionary of Irish Biography, a research project of the Royal Irish Academy, is the most comprehensive and authoritative biographical dictionary yet published for Ireland. It comprises over 10,000 lives, which describe and assess the careers of subjects in all fields of endeavour, including politics, law, religion, literature, journalism, architecture, music and the arts, the sciences, medicine, entertainment and sport.

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Presenting a systematic approach to the chemistry of the p Block elements and hydrogen, this book also introduces some basic topics concerning chemical bonding, such as oxidation numbers, bond strengths, dipole moments and intermolecular forces. The chemistry is illustrated by coverage of the biological role of nitric oxide and of hydrogen bonding, and the new chemistry of carbon nanotubes. Applied aspects of the topic are developed in the two Case Studies, which examine the causes and prevention of acid rain and the inorganic chemical industry. The accompanying CD-ROMs cover silicate mineral structures, the inert pair effect and a database of chemical reactions of the p Block elements. The Molecular World series provides an integrated introduction to all branches of chemistry for both students wishing to specialise and those wishing to gain a broad understanding of chemistry and its relevance to the everyday world and to other areas of science. The books, with their Case Studies and accompanying multi-media interactive CD-ROMs, will also provide valuable resource material for teachers and lecturers. (The CD-ROMs are designed for use on a PC running Windows 95, 98, ME or 2000.)

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This book is divided into two parts. The first covers biomass modification to facilitate the industrial degradation processing and other characteristics of feedstocks. These include reduction in the general recalcitrance of plant cell wall and downstream processing costs. The second focuses on cutting edge technologies for the conversion of lignocelluloses into biofuels and other products. It describes the most up-to-date advances in natural biomass utilization systems, such as wood-feeding termites and animals that efficiently degrade lignocellulosic substrates. Consolidated bioprocessing (CBP) integrates cellulase production and cellulose hydrolysis, with pentose and hexose fermentation in a single step. This replicates what happens in the digestive systems of animals, such as termites and cows, that effectively degrade lignocellulosic substrates. CBP has the potential to reduce production costs and lower capital investment whilst increasing conversion efficiency. Currently, there are no CBP-enabling micro-organisms suitable for industrial applications. Consequently, this book presents technologies which integrate the lignocellulolytic systems of insects and other animals to advance CBP strategy for cellulosic biofuels. It covers the progress made, and challenges faced, with the utilisation of gene, catalyst, and other unique mechanisms from cellulose-eating animals, as well as cutting-edge technologies developed to reduce the general recalcitrance of feedstocks for processing. This volume makes essential reading for academics and industrial groups concerned with overcoming the challenges inherent in the biological conversion of biomass into fuels and chemicals.

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Corrosion affects every industry in which metal is involved, from manufacturing machinery to transport pipelines, and it is estimated to cost the global economy trillions of dollars per year. Many of the traditional methods for inhibiting corrosion are highly toxic (such as hexavalent chromium) or do not degrade readily in the environment (such as Benzotriazole) meaning they pose a risk to human and environmental health. Much recent work in the area has gone into searching for greener alternatives that will be both safe and effective. Beginning with a look at the fundamentals of corrosion inhibition and an explanation of the concepts of green chemistry, this book discusses various types of chemical that have been tested for their potential as greener corrosion inhibitors with reference to industrial applications. Green Corrosion Inhibition is a valuable reference for chemists and chemical engineers working in both research and design and academia who want to learn more about green corrosion inhibitors, their synthesis, design, and industrial scale applications.

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Modern research in biology increasingly relies on multiple techniques for describing structures and mechanisms. This book provides an overview of the contemporary integrated biology approaches for solving structures and understanding mechanisms of complex biological systems. It includes several methodology chapters discussing the current developments in the areas of cryo-electron microscopy (EM) and cryo-electron tomography (ET), computational biophysics, solution NMR spectroscopy, solid-state NMR spectroscopy and dynamic nuclear polarization (DNP), electron paramagnetic resonance (EPR), (photo-)chemically induced dynamic nuclear polarization (CIDNP), X-ray crystallography and small-angle X-ray and neutron scattering (SAXS/SANS). Several subsequent chapters demonstrate how these methods are used in synergy to address problems at the forefront of structural biology, with particular emphasis on examples where individual techniques are insufficient. Examples of biological systems include membrane proteins, viral protein assemblies, cytoskeleton protein assemblies, photosynthetic reaction centers, large enzyme complexes and whole cells. The book is targeted to both the current practitioners of structural biology and scientists who are interested in entering the fields of structural biology or biophysical chemistry.

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Since the early 20th century, X-ray and electron scattering has provided a powerful means by which the location of atoms can be identified in gas-phase molecules and condensed matter with sub-atomic spatial resolution. Scattering techniques can also provide valuable observables of the fundamental properties of electrons in matter such as an electron’s spin and its energy. In recent years, significant technological developments in both X-ray and electron scattering have paved the way to time-resolved analogues capable of capturing real-time snapshots of transient structures undergoing a photochemical reaction. Structural Dynamics with X-ray and Electron Scattering is a two-part book that firstly introduces the fundamental background to scattering theory and photochemical phenomena of interest. The second part discusses the latest advances and research results from the application of ultrafast scattering techniques to imaging the structure and dynamics of gas-phase molecules and condensed matter. This book aims to provide a unifying platform for X-ray and electron scattering.

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Supercapacitors can both hold large amounts of energy and charge up almost instantly. They have higher energy densities, higher efficiencies and longer lifetimes so can be used in a wide range of energy harvesting and storage systems including portable power and grid applications. Despite offering key performance advantages, many device components pose significant environmental hazards, often containing fluorine, sulfur and cyanide groups which are harmful when discarded. In recent years, there has been increasing research into more sustainable electrode materials for supercapacitor applications. In this book, readers are introduced to the extensive and ongoing research on the rationalization of low-carbon supercapacitor materials, their structures at varying scales and dimensions, the development of effective and low-cost synthesis techniques, design and architecture of green materials, as well as clarification of their electrochemical performance. It is an ideal book for researchers and industry professionals at the energy–environment nexus, searching for new advancements in supercapacitor science and technologies.

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Dynamic soft materials that have the ability to expand and contract, change stiffness, self-heal or dissolve in response to environmental changes, are of great interest in applications ranging from biosensing and drug delivery to soft robotics and tissue engineering. This book covers the state-of-the-art and current trends in the very active and exciting field of bioinspired soft matter, its fundamentals and comprehension from the structural-property point of view, as well as materials and cutting-edge technologies that enable their design, fabrication, advanced characterization and underpin their biomedical applications. The book contents are supported by illustrated examples, schemes, and figures, offering a comprehensive and thorough overview of key aspects of soft matter. The book will provide a trusted resource for undergraduate and graduate students and will extensively benefit researchers and professionals working across the fields of chemistry, biochemistry, polymer chemistry, materials science and engineering, nanosciences, nanotechnologies, nanomedicine, biomedical engineering and medical sciences.

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Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. With contributions from global leaders in the field, this book will serve as a useful reference to established researchers as well as a practical guide to those new to metallodrugs, and postgraduate students of medicinal chemistry and metallobiology.

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New technologies are made possible by new materials, and until recently new materials could only be discovered experimentally. Recent advances in solving the crystal structure prediction problem means that the computational design of materials is now a reality. Computational Materials Discovery provides a comprehensive review of this field covering different computational methodologies as well as specific applications of materials design. The book starts by illustrating how and why first-principle calculations have gained importance in the process of materials discovery. The book is then split into three sections, the first exploring different approaches and ideas including crystal structure prediction from evolutionary approaches, data mining methods and applications of machine learning. Section two then looks at examples of designing specific functional materials with special technological relevance for example photovoltaic materials, superconducting materials, topological insulators and thermoelectric materials. The final section considers recent developments in creating low-dimensional materials. With contributions from pioneers and leaders in the field, this unique and timely book provides a convenient entry point for graduate students, researchers and industrial scientists on both the methodologies and applications of the computational design of materials.

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Food Microbiology by Adams and Moss has been a popular textbook since it was first published in 1995. Now in its fourth edition, Peter McClure joins the highly successful authorship in order to bring the book right up to date. Maintaining its general structure and philosophy to encompass modern food microbiology, this new edition provides updated and revised individual chapters and uses new examples to illustrate incidents with particular attention being paid to images. Thorough and accessible, it is designed for students in the biological sciences, biotechnology and food science as well as a valuable resource for researchers, teachers and practising food microbiologists.

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The most comprehensive listing of the known useful plants for this country. Compiled by a team of Colombian and international botanists from the Royal Botanic Gardens, Kew, the Humboldt Institute and numerous partner institutions, it consolidates expert-generated information linked and accessible through an online portal (ColPlantA). The checklist is accompanied by 11 chapters written by specialists, providing perspectives on the state of knowledge on the useful plants of Colombia, covering a range of topics, from taxonomic, geographic and conservation aspects, to their use in sustainable value chains and contributions to the bioeconomy, specific topics such as medicinal, edible and insecticide plants, and their representation in the Amazon region, and in Kew’s economic botany collection. The catalogue is further enriched by diverse supplementary material.

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On a late summer day, many years ago, a young man set out on a voyage through the mountains. He never reached his destination. When his remains were discovered by three British Columbia hunters, roughly three hundred years after he was caught by a storm or other accident, his story had faded from even the long memory of the region’s people. First Nations elders decided to call the discovery Kwäday Dän Ts’ìnchi—Long Ago Person Found. The discovery of the Kwäday Dän Ts’ìnchi man raised many questions. Who was he and how did he die? Where had he come from? Where was he going, and for what purpose? What did his world look like? But his remains, preserved in glacial ice for centuries, offered answers, too—as did the traditional knowledge and experience of the Indigenous peoples in whose territories he lived and died. In this comprehensive and collaborative account, scientific analysis and cultural knowledge interweave to describe a life that ended just as Europeans were about to arrive in the northwest. What emerges is not only a portrait of an individual and his world, but also a model for how diverse ways of knowing, in both scholarly and oral traditions, can complement each other to provide a new understanding of our complex histories.

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Can scientists and engineers replicate Nature and develop systems that operate in extreme environments? Bio-inspiration is an established concept which is developing to meet the needs of the many challenges we face particularly in defence and security. This book explores the potential of bio-inspired materials and sensing systems together with examples of how they are being implemented. It is not an exhaustive study of the subject but provides an overview of how bio-inspired or -derived approaches can be used to enhance components, systems and systems of systems for defence and security applications. Readers will gain an awareness of the complexity and versatility of bio-inspired components as well as an understanding of how these technologies can be applied in a variety of operational scenarios. Consideration is given to using a conceptual model that can be deployed in distributed or autonomous operations. Using this model, bio-inspiration with behavioural science plays a major role in identification, movement, searching strategies and pattern recognition for chemical and biological detection. Examples focus on both learning new things from nature that have application to the defence and security areas and adapting known discoveries for practical use by these communities. This graduate level monograph provides an increased awareness of the need for more sophisticated, networked sensors and systems in the defence and security communities and will be of interest to both specialists in this area and science and technology generalists.

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