Search results for ""Author Leon""

This edited volume contains seven chapters, each detailing recent advancements in medicine and biology. Chapter One presents an overview of drug-related problems in pediatrics. Chapter Two evaluates the role that Maytenus ilicifolia can play in the treatment of melanoma skin cancer. Chapter Three presents a review of biosensors for lipopolysaccharides and assays for studies of lipopolysaccharide binding interactions. Chapter Four presents a literature review of treatment options for carpal tunnel syndrome. Chapter Five describes the application of metabolomics, a science that quantifies and qualifies metabolites in an organism, in bio-medical research. Chapter Six presents the results of a systematic screening that was performed to identify macromolecules that are able to induce accumulation of ascitic fluid in rodents. Finally, Chapter Seven describes a study wherein the method of gravitational mass spectroscopy was used to study the long-range order in an ensemble of atomic nuclei clusters in chicken egg yolk before and after adsorption by beet sugar on the chromosomes.

Read more less

This edited volume contains six chapters that each describe recent advancements in medicine and biology. Chapter One summarizes recent discoveries regarding the immunomodulatory effects of vitamin D3 on human health with an emphasis on the interplay of transcription factors and reviews the most recent recommendations based on new clinical evidence for vitamin D3 dosages for the prevention and treatment of COVID-19. Chapter Two focuses on idiopathic membranous nephropathy, the most common cause of nephrotic syndrome in adults who do not suffer from diabetes mellitus. Chapter Three details the emerging worldwide prevalence of myopathies, their evolving diagnostic parameters, and the newer therapeutic modalities. Chapter Four includes a review of medroxyprogesterone, which is a type of progestin that is used as a long-lasting injectable contraceptive and for the treatment of hormone-dependent tumours. Chapter Five describes synovial fluid, which lubricates and cushions joints during motion, and the effects of visco-supplements on the function of synovial fluid. Lastly, Chapter Six introduces the properties of dopamine acrylamide and discusses its application potential in detail.

Read more less

This edited volume presents seven chapters detailing recent advancements in the fields of medicine and biology. Chapter One describes the regularities of abzyme production in patients with autoimmune diseases as well as in experimental mice. Chapter Two reviews the partners that assist polytopic membrane proteins in their way to acquiring their final structure. Chapter Three presents an approach for the development of an efficient biological sensor for the detection of biochemicals in large scales. Chapter Four shows the different flavin-based fluorescent proteins and fatty-acid-binding proteins and the advantages and disadvantages of using these anaerobic fluorescent proteins for real-time imaging in complex systems versus aerobic fluorescent proteins. Chapter Five discusses the main benefits of exercise for cirrhotic patients and current exercise prescription guidelines for this population. Chapter Six concerns the role thiamine deficiency plays in causing paediatric lactic acidosis. Finally, Chapter Seven discusses the mechanism of wound healing involving stem cells in IIIa burns and proposes using the state of NC1 conformations as an objective indicator of epidermal restoration and the topology of solenoid chromosome construction as an indicator of dermis restoration.

Read more less

Volume 162 opens with an assessment of the modern available data, as well as the results from the authors' own research, on the neurotropic effects of amino acid L-arginine. The effects of L-arginine and some arginine-containing oligopeptides on pain and pain-induced behavior in rats are examined. Depending on their binding to activate specific receptors, antagonists have selective functions. As such, this compilation details their specificity, mode of interactions and their usefulness and drawbacks for humans. Next, a review on how CD14 interacts with different ligands is discussed, particularly focusing on how CD14 consequently transduces the signaling to induce some relevant diseases. The authors also review some trends in the treatment of anxiety with natural compounds and transition metal-catalyzed couplings for the synthesis of new drugs with anxiolytic properties. Natural products have been widely used in the treatment of anxiety disorders and as a source of bioactive heterocyclic compounds. Methods for improving the perception and attitude of health workers towards generic drugs are proposed, such as putting forward generic drugs as one of the learning topics in college curricula, and conducting scientific discussions and conferences on generic drugs through professional organizations. The penultimate study comprehensively reviews the clinicopathological features of lipoblastomas and emphasizes the importance of accurate diagnosis and the differentiation of lipoblastomas from other histologically similar lipomatous neoplasms. The closing study proposes that the relaxant effects of flavone may be due to the inhibition of enzyme activities and intracellular Ca2+ of the trachealis after increasing these two cyclic nucleotides.

Read more less

This compilation opens with a review of the structure and life cycle of neuraminidase in influenza A, and also discusses the method of developing neuraminidase inhibitors derived from natural products and peptides. Following this, the authors describe the different uses of chlorhexidine in the medical field, focusing on dental use. Particularly, the authors discuss its: properties, chemistry, forms of presentation, substantivity and cytotoxicity; uses in dentistry: cariology, periodontology, oral surgery and endodontics. Additionally, the authors discuss rufinamide, a novel triazole derivative which differs from commercial antiepileptic drugs. It is used as an adjunctive medicine in children, adults and the elder population, and administered orally. One study discusses antiviral treatment for the avian influenza A virus using neuraminidase inhibitors such as oseltamivir and zanamivir. Although both inhibitors show therapeutic and prophylactic activities against the H5N1 strains, it is proposed that treatment should be further developed in order to increase the efficiency of the inhibitors against the strains. Angiogenesis or neovascularization is a global term which indicates the physiological process involving the sprouting of new blood vessels from the pre-existing ones. The development of new blood vessels from differentiating endothelial cells is called vasculogenesis. This collection addresses how these processes are vital for tissue development and wound healing in damaged tissues. The spectrum of spondyloarthritides with inflammatory bowel disease and enteropathic arthritis is examined in an effort to give the reader an insight into the risk factors, treatment and prognosis of this clinically challenging rheumatic disease. Later, the principles of optical coherence tomography-guided femtosecond laser cataract surgery are explored. The combination of femtosecond laser surgery and optical coherence tomography imaging simultaneously guides the development of next-generation femtosecond surgical lasers in cataract surgery and explores femtosecond-laser surgical strategies. The authors present a novel colorimetric method for the assay of XI using a reducing monosaccharide determination. The test solution was mixed with 20-fold volume of the 50 mM Na2SiO3, 600 mM Na2MoO4, and 0.95 M HCl aqueous solution (pH 4.5), in which a yellow molybdosilicate species was formed. The penultimate chapter introduces the origin, preparation, applications of Taiyi Shenzhen (Taiyi Moxa Stick Moxibustion), and reviews the relevant research in the past ten years. The concluding study focuses on the daily foraging of honeybees, which is one of the most well-organized social behaviors that exist among social insects. Honeybees are extensively used model animals in behavioral studies for understanding the time-space learning, landmark use and concept of learning.

Read more less

Advances in Medicine and Biology. Volume 150 first discusses how the emergence of multidrug resistant gram-negative bacteria, along with the lack of development of new antibiotics, led the medical community to look to polymyxins for therapeutical uses in critically ill patients. Next, the authors go on to discuss lenalidomide, a chemical analog of thalidomide and a member of the group of immunomodulatory or cereblon-binding drugs. Lenalidomide has antineoplastic, antiproliferative, antiangiogenic, anti-inflammatory, pro-erythropoieic, and immunomodulatory properties. Lenalidomide binds to a specific hydrophobic pocket in the protein cereblon. This pocket is coded by the exons 10 and 11 on the C-end of cereblon gene. Cereblon interacts with the DNA damage-binding protein-1, cullin 4, and regulator of cullins 1 to form the E3 ubiquitin ligase complex. Lenalidomide also enhances the antitumor effect of chimeric antigen receptor modified T cells in murine models of aggressive B-cell non-Hodgkin lymphoma. Lenalidomide has also been studied in the treatment of cutaneous manifestations of systemic lupus erythematosus and neurodegenerative disorders connected with neuroinflammation, such as amyotrophic lateral sclerosis. Additionally, the authors to discuss the current evidence on the use of troponin as a prognostication biomarker in neonatal encephalopathy, as well as the importance of monitoring cardiac function after hypoxic ischaemic brain damage. The basic science and clinical significance of CD180-negative plasmablasts in various autoimmune and inflammatory diseases is reviewed. In systemic and organ-specific autoimmune diseases, CD180-negative plasmablasts play crucial roles and are useful as a disease marker. Because CD180 has a complex function, the mechanism of the increase of CD180 negative B cells may be different in each disease. In closing, the concept of intensive care rehabilitation was developed with the Federal Rehabilitation Council BAR. Both early rehabilitation for neurological and neurosurgical patients and intensive care rehabilitation for patients with other critical illnesses are detailed.

Read more less

'Trust me: you want to read this. It's the queer horror book of your dreams' Kirsty Logan'The short, twisted tales collected in Leon Craig's Parallel Hells have a laconic elegance that's both chilling and pleasurable' Financial TimesIn this deliciously strange debut collection, Leon Craig draws on folklore and gothic horror in refreshingly inventive ways to explore queer identity, love, power and the complicated nature of being human.In the thirteen darkly audacious stories of Parallel Hells we meet a golem, made of clay, learning that its powers far exceed its Creator's expectations; a ruined mansion which grants the secret wishes of a group of revellers and a notorious murderer who discovers her Viking husband is not what he seems.Asta is an ancient being who feasts on the shame of contemporary Londoners, who now, beyond anything, wishes only to fit in with a group of friends they will long outlive. An Oxford historian, in bitter competition with the rest of her faculty members, discovers an ancient tome whose sinister contents might solve her problems. Livia orchestrates a Satanic mass to distract herself from a recently remembered trauma and two lovers must resolve their differences in order to defy a lethal curse.'A glorious collection of short stories that reads as if Edgar Allan Poe and Shirley Jackson had a little queer baby' Big Issue'Impressive... Read Parallel Hells for a different take on vampires, demons and monsters you never knew existed... Craig's worlds appear effortless' Mslexia

Read more less

Packed with physical facts and healthy hints - find out why healthy kids choose to understand puberty!Find out what happens to a body in puberty and why, and how these changes can affect your mental health. Whatever stage of maturity you''re facing, this book has something for everyone: from hormones and spots to emotional and relational health during puberty. And don''t forget about healthy eating - it is also key to managing puberty!The HEALTHY KIDS series encourages children aged 9-11 to make healthy lifestyle choices with knowledge that will benefit them throughout their lives. Discover positive, practical and to-the-point advice on everything from puberty and fitness, to staying safe and keeping clean.Books in the series:Healthy Kids: Eat Healthy FoodHealthy Kids: Exercise Your Body Healthy Kids: Keep Yourself Clean Healthy Kids: Keep Yourself SafeHealthy Kids: Understand Puberty

Read more less

El Imperio español estaba formado por las piezas sueltas de unrompecabezas. Y muchas de las piezas contiguas estaban ocupadaspor enemigos de todo tipo. Tal dispersión hacía difícil defender a lavez tanto territorio disgregado. A pesar de ello, el Imperio españoltampoco perdió demasiado por la fuerza de las armas enemigas.Desde luego, una parte increíblemente pequeña habida cuenta ladispersión geográfi ca, los muchos frentes abiertos y la multitud deenemigos cuyo objetivo último era justamente ese: arrancar unbocado al gigante. Los territorios hispánicos se perdieron en sumayor parte por tratados, no por ocupación armada enemiga, y elfi nal del Imperio se produjo por la implosión de las guerras deemancipación americana. Solo los restos del Imperio, Cuba, PuertoRico y Filipinas cayeron en una última guerra calamitosa.Este libro se ocupa de naciones, pueblos, colectivos o inclusoindividuos que fueron enemigos del Imperio español, por

Read more less

Drawing upon close to thirty years of teaching experience, Leon Spreyer provides teachers with practical information that is not always taught in teacher education courses. New and veteran teachers alike will find useful advice for managing their work both in and out of the classroom. The book covers eighty-two essential topics, including cooperative learning, managing parents, staff meetings, implementing tests, portfolios, setting rules, and much more.Highlights include:Practical advice on more than eighty subjectsBook suggestions and games for the classroomSuggestions for staying motivated and avoiding burnoutTeaching ability, wisdom, and fervor are not inborn; teachers learn the elements of their art. With that in mind, Spreyer provides information, games, book recommendations, specific lesson plans, and straightforward advice on all aspects of teaching, ranging from Back-to-School Night to power in the classroom, and from homework to substitute teachers. And he does it in a reader-friendly style, with easy-to-follow lists, examples, and suggested resources.

Read more less

A cycle of eleven episodes told in Story Theater form a narrator speaking and life-sized puppets performing simultaneously ÊThe Greek MythsÊ tells the story of Greek mythology from the first moments of creation through its version of the story of the flood the reign of Zeus and the trials tribulations and joys during Zeus's long and continuing reign. It brings to life some of the most memorable episodes and characters in that saga: the Titans the Cyclops Zeus himself Echo and Narcissus Cupid and Psyche Theseus Orpheus and Euridice and many many more. This version of the stories by playwright Leon Katz is based on the Roman poet Ovid's epic poem ÊMetamorphosesÊ the most popular and witty retelling of the tales in Western literature.ÞÊThe Greek MythsÊ has an impressive track record. It ran for ten years in the Vagabond Puppet Company's production and during that time toured throughout the US. Its appeal has been strong with both young audiences and adults alike and was seen by thousands of theatregoers.ÞLois Bohovesky artistic director of the Vagabond Puppet Company explains For life-sized puppets performing Greek myths for children the script had to be exciting humorous and certainly accurate the language crystal clear and the poetry flowing naturally as speech ... We all know people like these gods ä Zeus for instance the consummate politician. The play is full of humor and the characters so well written that the actor's job is an easy one.

Read more less

In the decades following World War II, American liberals had a vision for the world. Their ambitions would not stop at the water’s edge: progressive internationalism, they believed, could help peoples everywhere achieve democracy, prosperity, and freedom. Chastened in part by the failures of these grand aspirations, in recent years liberals and the Left have retreated from such idealism. Today, as a beleaguered United States confronts a series of crises, does the postwar liberal tradition offer any useful lessons for American engagement with the world?The historian Leon Fink examines key cases of progressive influence on postwar U.S. foreign policy, tracing the tension between liberal aspirations and the political realities that stymie them. From the reconstruction of post-Nazi West Germany to the struggle against apartheid, he shows how American liberals joined global allies in pursuit of an expansive political, social, and economic vision. Even as liberal internationalism brought such successes to the world, it also stumbled against domestic politics or was blind to the contradictions in capitalist development and the power of competing nationalist identities. A diplomatic history that emphasizes the roles of social class, labor movements, race, and grassroots activism, Undoing the Liberal World Order suggests new directions for a progressive American foreign policy.

Read more less

Eighteen years have passed since ten countries from Central & Eastern Europe joined the European Union and more than three decades since the Berlin Wall was torn down in 1989 - but ignorance about what is popularly still called Eastern Europe is as widespread as ever. Slovenia still gets mixed up with Slovakia, the Slavs remain a mystery in a Europe apparently dominated by Romanic and Germanic nations and a country like the Czech Republic is labelled as Eastern European, although one needs to travel west to get from Vienna to Prague. First published in 2009 under the title What's so eastern about Eastern Europe?, this book is much more than a revised and updated version of the first edition. Its presentation of the political and cultural history of Central, Eastern and South-Eastern Europe, written in an accessible language is now complemented with recent developments in the region. The new edition digs into the reasons behind the illiberal turn in Poland, Hungary and elsewhere, putting the alleged democratic backslide into the wider context of European populism. Leon Marc offers a new and fresh perspective in explaining the roots of populism and social conservatism in the region, which the book sees in a mixture of historical factors, economic conditions, the heavy burden of Communist legacy, as well as a reaction to contemporary social developments in the West. Drawing on a wide range of literature, the book calls for more sensibility to these underlying causes, critical examination of the true European values, and for a coalition of defenders of Humanism and Judeo-Christian tradition as key pillars of its identity, in order to save Europe and its liberal democracy. This updated and expanded edition contains a brand new chapter bringing this book up to date with recent events, including Covid-19 and the Ukrainian conflict.

Read more less

Touch screens have transformed our modern lives, allowing us to control equipment and communicate with each other through smart devices - all at the touch of a button. Discover how touch screens began as scientific resources, how they were changed into the fun and practical gadgets we use today and what the future of these adaptable and inventive devices could be. High-Tech Science is a series of four books that look at the revolutionary, cutting-edge science that we rely on to run our lives and keep our modern world working.

Read more less