Search results for ""Springer-Verlag New York Inc.""

Not only computer scientists, but also electrical engineers, and others interested in electronics are targeted here, and thus the presentation is directed toward understanding how a computer works, while still providing a broad and effective one-year introduction to classical and modern physics. The first half of the book covers many of the topics found in a standard introductory physics course, but with the selection tailored for use in the second half. This second part then covers the fundamentals of quantum mechanics, multi-electron systems, crystal structure, semiconductor devices, and logic circuits. All the mathematical complexities treated are alleviated by intuitive physical arguments, and students are encouraged to use their own programming to solve problems. The only prerequisite is some knowledge of calculus, and the second part can serve by itself as an introduction to the physics of electronics for students who have had a standard two-semester introductory physics course. In this second edition, much of the material on electronic devices has been brought up to date, and there is a new chapter on integrated circuits and heterostructures.

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Sixteen years have passed since human aquaporin-1 (AQP1) was discovered as the first water channel, facilitating trans-membrane water fluxes. Subsequent years of research showed that the water channel AQP1 was only the tip of an iceberg; the iceberg itself being the ubiquitous super family of membrane intrinsic proteins (MIPs) that facilitate trans-membrane transport of water and an increasing number of small, water-soluble and uncharged compounds. Here we introduce you to the superfamily of MIPs and provide a summary about our gradually refined understanding of the phylogenetic relationship of its members. This volume is dedicated to the metalloids, a recently discovered group of substrates for a number of specific MIPs in a diverse spectrum of organisms. Particular focus is given to the essential boron, the beneficial silicon and the highly toxic arsenic. The respective MIP isoforms that facilitate the transport of these metalloids include members from several clades of the phylogenetic tree, suggesting that metalloid transport is an ancient function within this family of channel proteins. Among all the various substrates that have been shown to be transported by MIPs, metalloids take an outstanding position. While water transport seems to be a common function of many MIPs, single isoforms in plants have been identified as being crucially important for the uptake of boric acid as well as silicic acid. Here, the function seems not to be redundant, as mutations in those genes render plants deficient in boron and silicon, respectively.

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Introduction to Focused Ion Beams is geared towards techniques and applications. This is the only text that discusses and presents the theory directly related to applications and the only one that discusses the vast applications and techniques used in FIBs and dual platform instruments.

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Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.

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The Verilog Hardware Description Language (Verilog-HDL) has long been the most popular language for describing complex digital hardware. It started life as a prop- etary language but was donated by Cadence Design Systems to the design community to serve as the basis of an open standard. That standard was formalized in 1995 by the IEEE in standard 1364-1995. About that same time a group named Analog Verilog International formed with the intent of proposing extensions to Verilog to support analog and mixed-signal simulation. The first fruits of the labor of that group became available in 1996 when the language definition of Verilog-A was released. Verilog-A was not intended to work directly with Verilog-HDL. Rather it was a language with Similar syntax and related semantics that was intended to model analog systems and be compatible with SPICE-class circuit simulation engines. The first implementation of Verilog-A soon followed: a version from Cadence that ran on their Spectre circuit simulator. As more implementations of Verilog-A became available, the group defining the a- log and mixed-signal extensions to Verilog continued their work, releasing the defi- tion of Verilog-AMS in 2000. Verilog-AMS combines both Verilog-HDL and Verilog-A, and adds additional mixed-signal constructs, providing a hardware description language suitable for analog, digital, and mixed-signal systems. Again, Cadence was first to release an implementation of this new language, in a product named AMS Designer that combines their Verilog and Spectre simulation engines.

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This book presents both general and comprehensive observations of unsuccessful and successful experiences in water pollution trading programs within the U.S. These experiences help in understanding the major environmental, economic and regulatory barriers that prevent the application of pollution trading in water media to become successful. This work combines background information with real experience.

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Gerry Stahl Drexel University, Philadelphia, USA The theme of engaged learning with emerging technology is a timely and important one. This book proclaims the global relevance of the topic and sharpens its focus. I would like to open the book by sketching some of the historical context and dimensions of application, before the chapter authors provide the substance. Engagement with the world - To be human is to be engaged with other people in the world. Yet, there has been a dominant strain of thought, at least in the West, that directs attention primarily to the isolated individual as naked mind. From classical Greece to modern times, engagement in the daily activities of human existence has been denigrated. Plato (340 BC/1941) banished worldly engagement to a realm of shadows, removed from the bright light of ideas, and Descartes (1633/1999) even divorced our minds from our own bodies. It can be suggested that this is a particularly Western tendency, supportive of the emphasis on the individual agent in Christianity and capitalism. But the view of people as originally unengaged has spread around the globe to the point where it is now necessary everywhere to take steps to reinstate engagement through explicit efforts. Perhaps the most systematic effort to rethink the nature of human being in terms of engagement in the world was Heidegger’s (1927/1996). He argued that human existence takes place through our concern with other people and things that are meaningful to us.

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The Square Kilometre Array (SKA) Project is a global project to design and c- struct a revolutionary new radio telescope with of order 1 million square meters of collecting area in the wavelength range from3mto1cm.It will have two - ders of magnitude greater sensitivity than current telescopes and an unprecedented large instantaneous ?eld-of-view. These capabilities will ensure the SKA will play a leading role in solving the major astrophysical and cosmological questions of the day (see the science case at www.skatelescope.org/pages/page astronom.htm). The SKA will complement major ground- and space-based astronomical facilities under construction or planned in other parts of the electromagnetic spectrum (e.g. ALMA, JWST, ELT, XEUS,...). The current schedule for the SKA foresees a decision on the SKA site in 2006, a decisiononthedesignconceptin2009,constructionofthe?rstphase(international path?nder)from2010to2013,andconstructionofthefullarrayfrom2014to2020. The cost is estimated to be about 1000 M . TheSKAProjectcurrentlyinvolves45institutesin17countries,manyofwhich are involved in nationally- or regionally-funded state-of-the-art technical devel- ments being pursued ahead of the 2009 selection of design concept. This Special Issue of Experimental Astronomy provides a snapshot of SKA engineering act- ity around the world, and is based on presentations made at the SKA meeting in Penticton,BC,CanadainJuly2004.Topicscoveredincludeantennaconcepts,so- ware, signal transport and processing, radio frequency interference mitigation, and reports on related technologies in other radio telescopes now under construction. Further information on the project can be found at www.skatelescope.org.

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This detailed volume explores methods currently used to investigate the cell wall of various bacterial species and pathogens. By using a combination of genetic, molecular, biochemical, and cytological techniques, the protocols address many fundamental questions involving the composition, biosynthesis, and regulation of bacterial peptidoglycan. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips for troubleshooting and avoiding known pitfalls. Authoritative and practical, The Bacterial Cell Wall: Methods and Protocols provides current and future researchers with a compilation of many of the most important and useful procedures in a single resource.

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This detailed collection explores recent advances in molecular imaging techniques involving bioluminescence, currently employed in biolaboratories around the world. Volume 1 delves into techniques for the establishment of luciferins and luciferases, basic in vitro and in vivo applications, as well as protocols on multiplex imaging platforms. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Bioluminescence: Methods and Protocols, Fourth Edition, Volume 1 presents practical guidance for researchers and technical staff on how to proceed with bioluminescence studies in their laboratories.

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This volume covers the detection of structural variants (SVs), which require different strategies than the ones used for single nucleotide variants (SNVs). This book aims to provide readers with a combination of the latest “wet lab” methods and computational pipelines that target all SV classes. The chapters in this book cover topics such as detection of transposable elements (TEs) from short read data; long read sequencing used for multiple variable number tandem repeat analysis; genomic mosaicism in the nervous system; and optical genome mapping. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Genomic Structural Variants in Nervous System Disorders is a valuable resource for scientists and researchers interested in learning more about this important field.

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This volume provides methods and models for investigating the immunosuppressive subset of CD4+ T-cells, regulatory T-cells (Treg). Chapters guide readers through, basic protocols for analyzing Treg in mice and humans, single-cell analysis for analyzing Treg, and methods for the analysis of Treg in clinical application. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Regulatory T-Cells: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.

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This volume provides state-of-the-art methodology to functionalize microtubules and construct microtubule-based materials. Chapters consists of six sections detailing modification of microtubule structures, observation and control of microtubule movement, material applications of microtubules in vitro, development of microtubule-binding molecules, comprehensive approaches to analyze properties of microtubules, and functionalization of microtubules in living cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Microtubules: Methods and Protocols aims to provide useful information for construction of microtubule-based materials and help to create new ideas for the next-generation of materials and applications through detailed protocols.

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An Introduction to Statistical Learning provides an accessible overview of the field of statistical learning, an essential toolset for making sense of the vast and complex data sets that have emerged in fields ranging from biology to finance to marketing to astrophysics in the past twenty years. This book presents some of the most important modeling and prediction techniques, along with relevant applications. Topics include linear regression, classification, resampling methods, shrinkage approaches, tree-based methods, support vector machines, clustering, deep learning, survival analysis, multiple testing, and more. Color graphics and real-world examples are used to illustrate the methods presented. Since the goal of this textbook is to facilitate the use of these statistical learning techniques by practitioners in science, industry, and other fields, each chapter contains a tutorial on implementing the analyses and methods presented in R, an extremely popular open source statistical software platform.Two of the authors co-wrote The Elements of Statistical Learning (Hastie, Tibshirani and Friedman, 2nd edition 2009), a popular reference book for statistics and machine learning researchers. An Introduction to Statistical Learning covers many of the same topics, but at a level accessible to a much broader audience. This book is targeted at statisticians and non-statisticians alike who wish to use cutting-edge statistical learning techniques to analyze their data. The text assumes only a previous course in linear regression and no knowledge of matrix algebra.This Second Edition features new chapters on deep learning, survival analysis, and multiple testing, as well as expanded treatments of naïve Bayes, generalized linear models, Bayesian additive regression trees, and matrix completion. R code has been updated throughout to ensure compatibility.

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This fourth edition explores fully up-to-date standardly used cryopreservation, vitrification, and freeze-drying protocols for specimens that are used for research purposes, conservation of genetic reserves, and applications in agriculture and medicine. Beginning with a section on the fundamentals as well as the use of mathematical modeling to solve cryobiological problems, the book continues with sections on technological aspects of freezing and drying, analytical methods to study protectant loading of cells and tissues, cell behavior during freezing and drying, and thermodynamic properties of preservation solutions, as well as cryopreservation, vitrification, and freeze-drying protocols for a wide variety of samples and different applications. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and authoritative, Cryopreservation and Freeze-Drying Protocols, Fourth Edition serves as an ideal guide for researchers and technical assistants in academia and industry with a background in life sciences, medicine, or engineering who want to investigate freezing and drying of biological systems or set up methods to safely store biological specimens while maintaining their function upon reconstitution.The chapter “Freezing Technology: Control of Freezing, Thawing, and Ice Nucleation” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

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From the reviews: "The book has a broad and general coverage of both the mathematics and the numerical methods well suited for graduate students." Applied Mechanics Reviews #1 "This is a very well written book. The topics are developed with separate headings making the matter easily understandable. Computer programs are also included for many problems together with a separate chapter dealing with the application of computer programs to heat transfer problems. This enhances the utility of the book." Zentralblatt für Mathematik #1

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This book provides an introduction to probability theory and its applications. The emphasis is on essential probabilistic reasoning, which is illustrated with a large number of samples. The fourth edition adds material related to mathematical finance as well as expansions on stable laws and martingales. From the reviews: "Almost thirty years after its first edition, this charming book continues to be an excellent text for teaching and for self study." -- STATISTICAL PAPERS

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What determines whether complex life will arise on a planet, or even any life at all? Questions such as these are investigated in this groundbreaking book. In doing so, the authors synthesize information from astronomy, biology, and paleontology, and apply it to what we know about the rise of life on Earth and to what could possibly happen elsewhere in the universe. Everyone who has been thrilled by the recent discoveries of extrasolar planets and the indications of life on Mars and the Jovian moon Europa will be fascinated by Rare Earth, and its implications for those who look to the heavens for companionship.

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Most routine motor tasks are complex, involving load transmission through­ out the body, intricate balance, and eye-head-shoulder-hand-torso-leg coor­ dination. The quest toward understanding how we perform such tasks with skill and grace, often in the presence of unpredictable perturbations, has a long history. This book arose from the Ninth Engineering Foundation Con­ ference on Biomechanics and Neural Control of Movement, held in Deer Creek, Ohio, in June 1996. This unique conference, which has met every 2 to 4 years since the late 1960s, is well known for its informal format that promotes high-level, up-to-date discussions on the key issues in the field. The intent is to capture the high quality ofthe knowledge and discourse that is an integral part of this conference series. The book is organized into ten sections. Section I provides a brief intro­ duction to the terminology and conceptual foundations of the field of move­ ment science; it is intended primarily for students. All but two of the re­ maining nine sections share a common format: (l) a designated section editor; (2) an introductory didactic chapter, solicited from recognized lead­ ers; and (3) three to six state-of-the-art perspective chapters. Some per­ spective chapters are followed by commentaries by selected experts that provide balance and insight. Section VI is the largest section, and it con­ sists of nine perspective chapters without commentaries.

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In this comprehensive overview of Man’s relationship with his planet’s nearest neighbor, David Harland opens with a review of the robotic probes, namely the Rangers which returned television before crashing into the Moon, the Surveyors which 'soft landed' in order to investigate the nature of the surface, and the Lunar Orbiters which mapped prospective Apollo landing sites. He then outlines the historic landing by Apollo 11 and the final three missions of comprehensive geological investigations. He concludes with a review of the robotic spacecraft that made remote-sensing observations of the Moon. This Commemorative Edition includes a foreword by one of the original astronauts as well as an extra section reviewing the prospect of renewed exploration there. New graphics and images are also included.

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This book is for RF Engineers and, in particular, those engineers focusing mostly on RF systems and RFIC design. The author develops systematic methods for RF systems design, complete with a comprehensive set of design formulas. Its focus on mobile station transmitter and receiver system design also applies to transceiver design of other wireless systems such as WLAN. This comprehensive reference work covers a wide range of topics from general principles of communication theory, as it applies to digital radio designs to specific examples on implementing multimode mobile systems.

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This unique book contains all topics of importance to the analog designer which are essential to obtain sufficient insights to do a thorough job. The book starts with elementary stages in building up operational amplifiers. The synthesis of opamps is covered in great detail. Many examples are included, operating at low supply voltages. Chapters on noise, distortion, filters, ADC/DACs and oscillators follow. These are all based on the extensive amount of teaching that the author has carried out world-wide.

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This comprehensive and topical volume presents a number of significant advances on many fronts in this area of research, particularly emphasizing current and future biomedical applications of electromagnetic fields.

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A solid introduction to basic continuum mechanics, emphasizing variational formulations and numeric computation. The book offers a complete discussion of numerical method techniques used in the study of structural mechanics.

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This book explains the basic methods of modern cryptography. It is written for readers with only basic mathematical knowledge who are interested in modern cryptographic algorithms and their mathematical foundation. Several exercises are included following each chapter. From the reviews: "Gives a clear and systematic introduction into the subject whose popularity is ever increasing, and can be recommended to all who would like to learn about cryptography." --ZENTRALBLATT MATH

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This second edition of Grune and Jacobs’ brilliant work presents new developments and discoveries that have been made in the field. Parsing, also referred to as syntax analysis, has been and continues to be an essential part of computer science and linguistics. Parsing techniques have grown considerably in importance, both in computer science, ie. advanced compilers often use general CF parsers, and computational linguistics where such parsers are the only option. They are used in a variety of software products including Web browsers, interpreters in computer devices, and data compression programs; and they are used extensively in linguistics.

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The goal of this book is to show how to build and manage a food safety department that is tasked with ensuring food safety within a food retail business. The experiences of the author as the head of Food and Product Safety at Chick-fil-A will be used as the model. Specifically, the book will discuss the specific components of a food safety program, the tactics needed to establish these components (forming the majority of the chapters), how to measure the success of each component, and how to influence the organization to ensure resources to support the program. The book will also focus on how to choose and work with the appropriate partners, validate the value to the business, and initiate the new component throughout the organization, including how to sustain the component within the program. Five features of this book that make it distinctive are: Most current “How to” book on leading a food safety department from the perspective of a respected national brand Provides the proper organization and methods to manage the work necessary to ensure food safety within the organization Provides the means to utilize risk-based decisions linked to business practices that accommodate a business analysis model Demonstrates step-by-step examples that can be used for continuous improvement in sustaining food safety responsibilities Provides examples on how to gain influence and obtain resources to support food safety responsibilities

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Imagine that we had some way to look directly at the molecules in a living organism. An x-ray microscope would do the trick, or since we’re dreaming, perhaps an Asimov-style nanosubmarine (unfortunately, neither is currently feasible). Think of the wonders we could witness firsthand: antibodies atta- ing a virus, electrical signals racing down nerve fibers, proteins building new strands of DNA. Many of the questions puzzling the current cadre of sci- tists would be answered at a glance. But the nanoscale world of molecules is separated from our everyday world of experience by a daunting million-fold difference in size, so the world of molecules is completely invisible. I created the illustrations in this book to help bridge this gulf and allow us to see the molecular structure of cells, if not directly, then in an artistic rendition. I have included two types of illustrations with this goal in mind: watercolor paintings which magnify a small portion of a living cell by one million times, showing the arrangement of molecules inside, and comput- generated pictures, which show the atomic details of individual molecules. In this second edition of The Machinery of Life, these illustrations are presented in full color, and they incorporate many of the exciting scientific advances of the 15 years since the first edition.

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This detailed book provides an exhaustive picture of current methods to detect, isolate, and analyze extracellular vesicles (EVs) from diverse sources, now seen as potential disease biomarkers as well as tools for the development of new therapies. Beginning with a section on detection and isolation of EVs, the volume continues with chapters covering different methods to isolate and quantify EVs from specialized tissues/organs and body fluids, methods devoted to analyzing EV components, as well as cutting-edge methods to engineer EVs. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Extracellular Vesicles in Diagnosis and Therapy serves as an ideal guide for researchers seeking to learn more about the complexities of cell-to-cell communication.

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This lively introductory text exposes the student to the rewards of a rigorous study of functions of a real variable. In each chapter, informal discussions of questions that give analysis its inherent fascination are followed by precise, but not overly formal, developments of the techniques needed to make sense of them. By focusing on the unifying themes of approximation and the resolution of paradoxes that arise in the transition from the finite to the infinite, the text turns what could be a daunting cascade of definitions and theorems into a coherent and engaging progression of ideas. Acutely aware of the need for rigor, the student is much better prepared to understand what constitutes a proper mathematical proof and how to write one.Fifteen years of classroom experience with the first edition of Understanding Analysis have solidified and refined the central narrative of the second edition. Roughly 150 new exercises join a selection of the best exercises from the first edition, and three more project-style sections have been added. Investigations of Euler’s computation of ζ(2), the Weierstrass Approximation ­ Theorem, and the gamma function are now among the book’s cohort of seminal results serving as motivation and payoff for the beginning student to master the methods of analysis.

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From translating the patient’s medical records and test results to providing recommendations, the neuropsychological evaluation incorporates the science and practice of neuropsychology, neurology, and psychological sciences. The Little Black Book of Neuropsychology brings the practice and study of neuropsychology into concise step-by-step focus—without skimping on scientific quality. This one-of-a-kind assessment reference complements standard textbooks by outlining signs, symptoms, and complaints according to neuropsychological domain (such as memory, language, or executive function), with descriptions of possible deficits involved, inpatient and outpatient assessment methods, and possible etiologies. Additional chapters offer a more traditional approach to evaluation, discussing specific neurological disorders and diseases in terms of their clinical features, neuroanatomical correlates, and assessment and treatment considerations. Chapters in psychometrics provide for initial understanding of brain-behavior interpretation as well as more advanced principals for neuropsychology practice including new diagnostic concepts and analysis of change in performance over time. For the trainee, beginning clinician or seasoned expert, this user-friendly presentation incorporating ‘quick reference guides’ throughout which will add to the practice armentarium of beginning and seasoned clinicians alike. Key features of The Black Book of Neuropsychology: Concise framework for understanding the neuropsychological referral. Symptoms/syndromes presented in a handy outline format, with dozens of charts and tables. Review of basic neurobehavioral examination procedure. Attention to professional issues, including advances in psychometrics and diagnoses, including tables for reliable change for many commonly used tests. Special “Writing Reports like You Mean It” section and guidelines for answering referral questions. Includes appendices of practical information, including neuropsychological formulary. The Little Black Book of Neuropsychology is an indispensable resource for the range of practitioners and scientists interested in brain-behavior relationships. Particular emphasis is provided for trainees in neuropsychology and neuropsychologists. However, the easy to use format and concise presentation is likely to be of particular value to interns, residents, and fellows studying neurology, neurological surgery, psychiatry, and nurses. Finally, teachers of neuropsychological and neurological assessment may also find this book useful as a classroom text."There is no other book in the field that covers the scope of material that is inside this comprehensive text. The work might be best summed up as being a clinical neuropsychology postdoctoral residency in a book, with the most up to date information available, so that it is also an indispensible book for practicing neuropsychologists in addition to students and residents…There is really no book like this available today. It skillfully brings together the most important foundationsof clinical neuropsychology with the 'nuts and bolts' of every facet of assessment. It also reminds the more weathered neuropsychologists among us of the essential value of neuropsychological assessment…the impact of the disease on the patient’s cognitive functioning and behavior may only be objectively quantified through a neuropsychological assessment."Arch Clin Neuropsychol (2011) first published online June 13, 2011 Read the full review acn.oxfordjournals.org

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This comprehensive, yet user friendly, volume specifically focuses on cutaneous soft tissue tumors, one of the most challenging areas in dermatopathology. The text is richly illustrated and written in a user friendly fashion, by well-known experts in cutaneous soft tissue tumors, with an emphasis on a practical diagnostic approach. The text opens with a brief introduction on how to approach soft tissue tumors, followed by a guide to ancillary diagnostic tests and a thorough discussion of cutaneous soft tissue tumors and their non-mesenchymal mimics. The entities are described in terms of their clinical and pathologic features and differential diagnoses. Key pathologic features are summarized in a table format. Soft Tissue Tumors of the Skin will be of great value to surgical pathologists and dermatopathologists as well as residents and fellows in pathology and dermatology.

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This comprehensive guide covers the causes, characteristics, and presentations of acute kidney injury (AKI), as well as prevention and treatment. The first part of the book features chapters on the epidemiology and diagnosis of AKI. This is followed by sections on pathophysiology, clinical syndromes and patient management. Authored by leading clinicians, epidemiologists, basic scientists, and clinical trialists, this book captures the latest evidence and best practices for treating patients with AKI.

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This book on NeuroAIDS, a collection of chapters written by experts and specialists from around the world, provides a global perspective on HIV and NeuroAIDS in the field, clinic, and laboratory. The chapters address the comorbidity of HIV and other infectious agents, including Zika virus, Ebola, Chagas disease, TB and HCV. Also discussed are key topics, such as:· Molecular socioepidemiology· Global HIV and NeuroAIDS· Neuropathology· cART and blood-brain barrier penetration· HIV replicative oscillations· HIV and SIV evolution· Psychiatric comorbidities· Neurosyphilis · The examination of current and innovative models of translational research to translational effectiveness

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This book offers ophthalmologists and medical practitioners a concise, data-driven review of the information that is most relevant in guiding the diagnosis and management of thyroid-associated eye diseases (TED). Thyroid-Associated Eye Disease can be read in its entirety to give a perspective of the field, but also considered as a reference as clinical questions arise. The goal is to deliver data- driven guidance and discreet approaches and suggestions useful for clinical practice and decision making. Advances in diagnostic evaluation, including autoantibody assessment, are reviewed, and the diagnostic features of euthyroid TED are also discussed. All relevant aspects of treatment are covered, from the use of radioactive iodine, long-term medical therapy, and surgical thyroidectomy through to the treatment of active TED by steroids and novel biologics and the role of minimally invasive surgery. Numerous supporting images are included, and helpful checklists will aid the practitioner in treatment decision making.

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Since the inaugural publication of Pediatric Dialysis in 2004, a wide range of advances have taken place in dialysis-related care, leading to a wealth of new knowledge in the field. Pediatric Dialysis, Second Edition brings this knowledge together to provide the most comprehensive source of state-of-the-art information on the dialysis of infants, children and adolescents. With new chapters, updated chapters and references, and contemporary, unique perspectives from authors who are leaders in the global pediatric nephrology community, Pediatric Dialysis, Second Edition is, once again, an authoritative reference that will facilitate best practices in both acute and chronic dialysis. Experienced clinicians and trainees alike will find Pediatric Dialysis, Second Edition not only another valuable contribution to the literature but an indispensable guide to managing their pediatric patients on dialysis.

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This volume is the third in a series on depressive illness. The first volume, entitled Phenomenology of Depressive Illness, is devoted to a de­ scription of depressive illness from a variety of perspectives that include those of the patient, the clinician, and the psychiatric researcher. It de­ scribes the major subtypes of depressive illness and places them in the context of the life cycle. The second volume in this series is entitled Models of Depres­ sive Disorders: Psychological, Biological, and Genetic Perspectives. This volume describes several major models of depressive disorders, in­ cluding genetic, cognitive, interpersonal, intrapsychic, and neurobio­ logical models. The third and fourth volumes deal with the biology of affective disorders in detail. These volumes are distinguished by a triaxial ap­ proach. In Volume III the biology of affective disorders is described from the perspective of individual transmitter systems and neurophysi­ ologic and biologic processes. In Volume IV the biology of depression is addressed from the vantage point of symptom components of de­ pression, and similarities and differences in the biology of depression are described compared to other psychiatric disorders with clinically overlapping features such as anxiety disorders or eating disorders. The effects on biology of comorbid conditions such as anxiety, personal­ ity disorders, alcoholism, and eating disorders are reviewed. These ap­ proaches incorporate issues of state versus trait.

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This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those in the pharmaceutical industry. The Fourth Edition will completely update the previous edition, and will also include additional coverage on the newer approaches such as oligonucleotides, siRNA, gene therapy and nanotech.

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Manual of Diagnostic and Therapeutic Techniques for Disorders of Deglutition is the first in class comprehensive multidisciplinary text to encompass the entire field of deglutition. The book is designed to serve as a treasured reference of diagnostics and therapeutics for swallowing clinicians from such diverse backgrounds as gastroenterology, speech language pathology, otolaryngology, rehabilitation medicine, radiology and others.Manual of Diagnostic and Therapeutic Techniques for Disorders of Deglutition brings together up-to-date information on state-of-the–art diagnostic and therapeutic modalities form disciplines of gastroenterology, speech language pathology, otolaryngology and radiology through contributions of 28 innovators, and master clinicians for the benefit of patients and providers alike. It concisely organizes the wealth of knowledge that exists in each of the contributing disciplines into one comprehensive information platform. Manual of Diagnostic and Therapeutic Techniques for Disorders of Deglutition provides a one-stop destination for members of all specialties to obtain state-of-the-knowledge information on advanced diagnostic modalities and management. It is an essential reference for all deglutologists.

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Number theory, spectral geometry, and fractal geometry are interlinked in this in-depth study of the vibrations of fractal strings, that is, one-dimensional drums with fractal boundary.Throughout Geometry, Complex Dimensions and Zeta Functions, Second Edition, new results are examined and a new definition of fractality as the presence of nonreal complex dimensions with positive real parts is presented. The new final chapter discusses several new topics and results obtained since the publication of the first edition.

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Focusing on the nuts and bolts of wireless network access for computers on board vehicles, this volume shows how in-car computerization now does much more than merely act as a glorified map-reader. Wireless communication is transforming road travel in ways previously undreamt of, allowing vehicles to “talk” to a wider network and monitor road conditions, potential delays and traffic congestion, all automatically. Toll payments can be made without opening the driver’s window on a cold day, while vehicles might themselves take active steps to avoid collisions. It is the connection between on-board computers and wireless access points, ubiquitous in most cities now, that is a key area of research. Moving vehicles transfer their communications to new points as they progress, and this causes delays, known as “handover latency”. In this book, new stochastic models are developed to map the disruption when connecting to 802.11 WLAN points. It details the application of stochastic tools to analyzing communication networks, as well as previous literature on handover latency and relevant mathematical modeling. Finally, it presents a scheme for monitoring traffic congestion using WLAN connectivity. This volume will be a useful addition to the libraries both of wireless communication students and those studying probability theory.

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Soils and Foundations for Architects and Engineers, Second Edition is a practical guide to the technology of soil mechanics and foundations, and the application of that technology to the design and construction process. This text provides an up-to-date overview of the classification of soils, the design of foundations, and the behavior of soils under load. Particular emphasis has been given to the subject of piles, piers, and caissons, and to the design and details of construction of basement and retaining walls. New to this edition: Expanded coverage of shear strength of soils, settlement analysis, and expansive soil. Design requirements for prestressed tiebacks, tiedowns, and rock anchors. Expansion of information on pile driving techniques including the use of the Engineering News Formula. A table of British-metric conversions. Many new solved problems and illustrations. In addition to the numerous new improvements, the author also includes: effects of high water tables on architectural and engineering considerations, design of shear keys used in the transfer of lateral earth pressure from a wall to the supporting element, various drainage alternatives to the structural treatment of adjacent footings, and much more. Soils and Foundations for Architects and Engineers, Second Edition can be used in advanced undergraduate and graduate level courses offered in architectural engineering and civil engineering, as well as be used as a reference book by practicing architects, insurance adjusters and attorneys who litigate or adjudicate claims involving soils and foundations.

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R is a powerful and free software system for data analysis and graphics, with over 5,000 add-on packages available. This book introduces R using SAS and SPSS terms with which you are already familiar. It demonstrates which of the add-on packages are most like SAS and SPSS and compares them to R's built-in functions. It steps through over 30 programs written in all three packages, comparing and contrasting the packages' differing approaches. The programs and practice datasets are available for download.The glossary defines over 50 R terms using SAS/SPSS jargon and again using R jargon. The table of contents and the index allow you to find equivalent R functions by looking up both SAS statements and SPSS commands. When finished, you will be able to import data, manage and transform it, create publication quality graphics, and perform basic statistical analyses. This new edition has updated programming, an expanded index, and even more statistical methods covered in over 25 new sections.

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The literature on equilibrium behavior of customers and servers in queuing systems is rich. However, there is no comprehensive survey of this field. Moreover, what has been published lacks continuity and leaves many issues uncovered. One of the main goals of this book is to review the existing literature under one cover. Other goals are to edit the known results in a unified manner, classify them and identify where and how they relate to each other, and fill in some gaps with new results. In some areas we explicitly mention open problems. We hope that this survey will motivate further research and enable researchers to identify important open problems. The models described in this book have numerous applications. Many examples can be found in the cited papers, but we have chosen not to include applications in the book. Many of the ideas described in this book are special cases of general principles in Economics and Game Theory. We often cite references that contain more general treatment of a subject, but we do not go into the details. we have highlighted the results For each topic covered in the book, that, in our opinion, are the most important. We also present a brief discussion of related results. The content of each chapter is briefly de­ scribed below. Chapter 1 is an introduction. It contains basic definitions, models and solution concepts which will be used frequently throughout the book.

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A revolution in working with difficult students began during the 1980s, with a dramatic shift away from dependence on simply punishing bad behavior to reinforcing desired, positive behaviors of children in the classroom. With its foundation in applied behavior analysis (ABA), positive behavior support (PBS) is a social ecology approach that continues to play an increasingly integral role in public education as well as mental health and social services nationwide. The Handbook of Positive Behavior Support gathers into one concise volume the many elements of this burgeoning field and organizes them into a powerful, dynamic knowledge base – theory, research, and applications. Within its chapters, leading experts, including the primary developers and researchers of PBS: (1) Review the origins, history, and ethical foundations of positive behavior support. (2) Report on applications of PBS in early childhood and family contexts, from Head Start to foster care to mental health settings to autism treatment programs. (3) Examine school-based PBS used to benefit all students regardless of ability or conduct. (4) Relate schoolwide PBS to wraparound mental health services and the RTI (response to intervention) movement. (5) Provide data and discussion on a variety of topics salient to PBS, including parenting issues, personnel training, high school use, poorly functioning schools, and more. This volume is an essential resource for school-based practitioners as well as clinicians and researchers in clinical child, school, and educational psychology.

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Driven by counter-terrorism efforts, marketing analysis and an explosion in online social networking in recent years, data mining has moved to the forefront of information science. This proposed Special Issue on Data Mining for Social Network Data will present a broad range of recent studies in social networking analysis. It will focus on emerging trends and needs in discovery and analysis of communities, solitary and social activities, activities in open for a and commercial sites as well. It will also look at network modeling, infrastructure construction, dynamic growth and evolution pattern discovery using machine learning approaches and multi-agent based simulations. Editors are three rising stars in world of data mining, knowledge discovery, social network analysis, and information infrastructures, and are anchored by Springer author/editor Hsinchun Chen (Terrorism Informatics; Medical Informatics; Digital Government), who is one of the most prominent intelligence analysis and data mining experts in the world.

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Taken literally, the title "All of Statistics" is an exaggeration. But in spirit, the title is apt, as the book does cover a much broader range of topics than a typical introductory book on mathematical statistics. This book is for people who want to learn probability and statistics quickly. It is suitable for graduate or advanced undergraduate students in computer science, mathematics, statistics, and related disciplines. The book includes modern topics like non-parametric curve estimation, bootstrapping, and classification, topics that are usually relegated to follow-up courses. The reader is presumed to know calculus and a little linear algebra. No previous knowledge of probability and statistics is required. Statistics, data mining, and machine learning are all concerned with collecting and analysing data.

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This is the only book that gives a rigorous and comprehensive treatment with lots of examples, exercises, remarks on this particular level between the standard first undergraduate course and the first graduate course based on measure theory. There is no competitor to this book. The book can be used in classrooms as well as for self-study.

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