Search results for ""Springer-Verlag New York Inc.""

These volumes represent a comprehensive guide to prodrugs. They guide the reader through the current status of the prodrug concept and its many applications and highlight its many successes in overcoming formulation and delivery of problematic drugs. Replete with examples of approved and marketed prodrugs, these volumes introduce the topic to the novice as well as professional in the design of prodrugs.

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This volume in the Springer Series in Evolutionary Psychology presents a state of the art view of the topic of sexuality and sexual behavior drawing on theoretical constructs and research of noted individuals in the field. Comprehensive and multi-disciplinary, this book seeks to provide a broad overview without sacrificing the complexity of a multi-faceted approach. The book is framed by introductory and closing sections that provide a context for the range of ideas contained within. Ample space is provided in designated sections that focus on key areas of sexuality from both male and female perspectives and that include information from primate studies. This volume can serve as a graduate text in sexual behavior in evolutionary terms and as a guide for further research.

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The vitreous body long has been the most mysterious of all ocular structures, owing perhaps to its seeming simplicity. There have been few concerted, sustained efforts to unravel the mysteries of how vitreous is composed and what role it plays in normal physiology as well as pathology. Over the years, however, many studies have produced important findings concerning vitreous biochemistry, structure, physiology, and pathobiology. Published on the 25th anniversary of Sebag's first book on Vitreous, this second installment is nearly five times longer than its predecessor, reflecting how much has been learned in the past quarter century. This well-constructed compendium not only addresses the most current scientific knowledge, but also reviews clinical perspec­tives in a manner that lends richness to the scope of the book. Written by 90 authors, this book has 56 chapters organized into 7 sections: Biochemistry; Anatomy, Development, and Aging; Pathology/Pathobiology; Physiology and Phamacotherapy; Posterior Vitreo-Retinal Surgery; Peripheral Vitreo-Retinal Surgery; and Pharmacologic Vitreolysis. With a foreword by Coleman & Lincoff and an introduction by Wallace Foulds, Sebag's latest tome on vitreous is destined to be the authoritative text for years to come.

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This volume details the essential role of the spiral ganglion neurons. The volume elucidates and characterizes their development, their environment, their electrophysiological characteristics, their connectivity to their targets in the inner ear and the brain, and discusses the potential for their regeneration. A comprehensive review about the spiral ganglion neurons is important for researchers not only in the inner ear field but also in development, neuroscience, biophysics as well as neural networks researchers. The chapters are authored by leading researchers in the field.

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In this edition, a set of Supplementary Notes and Remarks has been added at the end, grouped according to chapter. Some of these call attention to subsequent developments, others add further explanation or additional remarks. Most of the remarks are accompanied by a briefly indicated proof, which is sometimes different from the one given in the reference cited. The list of references has been expanded to include many recent contributions, but it is still not intended to be exhaustive. John C. Oxtoby Bryn Mawr, April 1980 Preface to the First Edition This book has two main themes: the Baire category theorem as a method for proving existence, and the "duality" between measure and category. The category method is illustrated by a variety of typical applications, and the analogy between measure and category is explored in all of its ramifications. To this end, the elements of metric topology are reviewed and the principal properties of Lebesgue measure are derived. It turns out that Lebesgue integration is not essential for present purposes-the Riemann integral is sufficient. Concepts of general measure theory and topology are introduced, but not just for the sake of generality. Needless to say, the term "category" refers always to Baire category; it has nothing to do with the term as it is used in homological algebra.

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In the last decade, the areas of quadratic and higher degree forms have witnessed dramatic advances. This volume is an outgrowth of three seminal conferences on these topics held in 2009, two at the University of Florida and one at the Arizona Winter School. The volume also includes papers from the two focused weeks on quadratic forms and integral lattices at the University of Florida in 2010.Topics discussed include the links between quadratic forms and automorphic forms, representation of integers and forms by quadratic forms, connections between quadratic forms and lattices, and algorithms for quaternion algebras and quadratic forms. The book will be of interest to graduate students and mathematicians wishing to study quadratic and higher degree forms, as well as to established researchers in these areas. Quadratic and Higher Degree Forms contains research and semi-expository papers that stem from the presentations at conferences at the University of Florida as well as survey lectures on quadratic forms based on the instructional workshop for graduate students held at the Arizona Winter School. The survey papers in the volume provide an excellent introduction to various aspects of the theory of quadratic forms starting from the basic concepts and provide a glimpse of some of the exciting questions currently being investigated. The research and expository papers present the latest advances on quadratic and higher degree forms and their connections with various branches of mathematics.

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This book is the first comprehensive, full-scale treatment of the law, politics and economics with regard to the policies and policy instruments for budget stabilization at the state level. Covering the period from 1946 through 2008 in the United States, it provides details on the methods and results of empirical tests of the effects of budget stabilization instruments on government operations, public service provision, and some other aspects of social and economic life. With the lingering effects of the most recent financial crisis and economic downturn, and the subsequent Tea Party movement advocating smaller government and deficit reduction, this book carries timely and important theoretical as well as practical implications, particularly in regard to the potential for counter-cyclical fiscal policy in mitigating negative impacts during a recession. The first contribution of the book is in public finance theory: it provides insights into the applications of the stabilization function in the context of strong government, thereby refining Keynesianism. The second aspect is in Public Choice: the creation and functioning of budget stabilization funds offer extra evidence to demonstrate that the general public provides input and voice in more than the conventional ways when it comes to policy making, even in an area dominated by strong government. The third aspect is in policy making, exploring the opportunities for refining policy tools in preparation for future downturns.

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Is red wine good for you? And if so, why? How much? And what are the actual benefits? This addition to the SpringerBriefs in Cell Biology series thoroughly but succinctly answers these questions. It covers the biochemistry, health benefits and therapeutic potential of wine grapes. It begins with an overview of phytoalexin production in Vitis vinifera (Common Grape Vine), detailing the relationship of resveratrol to analogues such as pterostilbene, piceid and the viniferins (resveratrol oligomers). The discussion then turns to the hundreds of reports linking resveratrol and related grape vine polyphenols to various beneficial health effects especially cardio- and cerebro- vascular, metabolic, anti-inflammatory and more. Also addressed are the numerous intracellular mechanisms that have been shown to mediate the effects of these compounds in mammalian cells and tissues. Finally, the authors discuss aspects of polyphenol bioavailability and how this will influence choices taken for delivering these compounds as nutritional supplements. A brief chapter containing general conclusions and prospectus rounds out the information. ​

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In this book, we have attempted to produce a reference on high resolution focused ion beams (FIBs) that will be useful for both the user and the designer of FIB instrumentation. We have included a mix of theory and applications that seemed most useful to us. The field of FIBs has advanced rapidly since the application of the first field emission ion sources in the early 1970s. The development of the liquid metal ion source (LMIS) in the late 1960s and early 1970s and its application for FIBs in the late 1970s have resulted in a powerful tool for research and for industry. There have been hundreds of papers written on many aspects of LMIS and FIBs, and a useful and informative book on these subjects was published in 1991 by Phil Prewett and Grame Mair. Because there have been so many new applications and uses found for FIBs in the last ten years we felt that it was time for another book on the subject.

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"The IMO Compendium" is the ultimate collection of challenging high-school-level mathematics problems and is an invaluable resource not only for high-school students preparing for mathematics competitions, but for anyone who loves and appreciates mathematics.The International Mathematical Olympiad (IMO), nearing its 50th anniversary, has become the most popular and prestigious competition for high-school students interested in mathematics. Only six students from each participating country are given the honor of participating in this competition every year. The IMO represents not only a great opportunity to tackle interesting and challenging mathematics problems, it also offers a way for high school students to measure up with students from the rest of the world.Until the first edition of this book appearing in 2006, it has been almost impossible to obtain a complete collection of the problems proposed at the IMO in book form. "The IMO Compendium" is the result of a collaboration between four former IMO participants from Yugoslavia, now Serbia and Montenegro, to rescue these problems from old and scattered manuscripts, and produce the ultimate source of IMO practice problems. This book attempts to gather all the problems and solutions appearing on the IMO through 2009. This second edition contains 143 new problems, picking up where the 1959-2004 edition has left off.

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This multidisciplinary textbook is designed to be the standard on the subject and is geared for use by physicians who are involved in the care and/or diagnosis of cancer patients. Comprehensive coverage is provided on all aspects of radioguided surgery. Practical information is readily accessible and throughout there is an emphasis on improved decision making. Tables present the indications, performance, and interpretation of procedures at a glance. A wealth of illustrations, including a full-color insert, enhances the application of new concepts.

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The aim of this book is to bridge the gap between standard textbook models and a range of models where the dynamic structure of the data manifests itself fully. The common denominator of such models is stochastic processes. The authors show how counting processes, martingales, and stochastic integrals fit very nicely with censored data. Beginning with standard analyses such as Kaplan-Meier plots and Cox regression, the presentation progresses to the additive hazard model and recurrent event data. Stochastic processes are also used as natural models for individual frailty; they allow sensible interpretations of a number of surprising artifacts seen in population data. The stochastic process framework is naturally connected to causality. The authors show how dynamic path analyses can incorporate many modern causality ideas in a framework that takes the time aspect seriously. To make the material accessible to the reader, a large number of practical examples, mainly from medicine, are developed in detail. Stochastic processes are introduced in an intuitive and non-technical manner. The book is aimed at investigators who use event history methods and want a better understanding of the statistical concepts. It is suitable as a textbook for graduate courses in statistics and biostatistics.

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The basic problem of deformation theory in algebraic geometry involves watching a small deformation of one member of a family of objects, such as varieties, or subschemes in a fixed space, or vector bundles on a fixed scheme. In this new book, Robin Hartshorne studies first what happens over small infinitesimal deformations, and then gradually builds up to more global situations, using methods pioneered by Kodaira and Spencer in the complex analytic case, and adapted and expanded in algebraic geometry by Grothendieck. The author includes numerous exercises, as well as important examples illustrating various aspects of the theory. This text is based on a graduate course taught by the author at the University of California, Berkeley.

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Surgical robotics is a rapidly evolving field. With roots in academic research, surgical robotic systems are now clinically used across a wide spectrum of surgical procedures. Surgical Robotics: Systems Applications and Visions provides a comprehensive view of the field both from the research and clinical perspectives. This volume takes a look at surgical robotics from four different perspectives, addressing vision, systems, engineering development and clinical applications of these technologies. The book also: -Discusses specific surgical applications of robotics that have already been deployed in operating rooms -Covers specific engineering breakthroughs that have occurred in surgical robotics -Details surgical robotic applications in specific disciplines of surgery including orthopedics, urology, cardiac surgery, neurosurgery, ophthalmology, pediatric surgery and general surgery Surgical Robotics: Systems Applications and Visions is an ideal volume for researchers and engineers working in biomedical engineering.

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The claim once made by philosophers of unique knowledge of the essence of humanity and society has fallen into disrepute. Neither Platonic forms, divine revelation nor metaphysical truth can serve as the ground for legitimating social and political norms. On the political level many seem to agree that democracy doesn’t need foundations. Nor are its citizens expected to discuss the worth of their comprehensive conceptions of the good life. According to Rawls, for example, we have to accept that “politics in a democratic society can never be guided by what we see as the whole truth (…)”. (1993: 243) And yet we still call upon truth when we participate in defining the basic structure our society and argue why our opinions, beliefs and preferences need to be taken seriously. We do not think that our views need to be taken into account by others because they are our views, but because we think they are true. If in a democratic society citizens have to deal with the challenge of affirming their claims as true, we need to analyse the precise relationship between truth and democracy. Does truth matter to democracy and if so, what is the place of truth in democratic politics? How can citizens affirm the truth of their claims and accept - at the same time - that their truth is just one amongst many? Our book centers on the role of the public sphere in these pressing questions. It tries to give a comprehensive answer to these questions from the perspective of the main approaches of contemporary democratic theory: deliberative democracy, political pragmatism and liberalism. A confrontation of these approaches, will result in a more encompassing philosophical understanding of our plural democracy, which – in this era of globalization – is more complex than ever before. Because a good understanding of the function, meaning and shortcomings of the public sphere is essential to answering these questions, a good deal of the book addresses these issues. Historically, after all, the idea that citizens have to engage each other in discussion in order to determine the structure and goals of society, is connected to the rational ideal of a public sphere where conflicting views can be expressed, formed, and transformed. But hasn’t the collective decision making in which everyone participates on an equal footing turned out to be a deceptive ideal or a simple illusion? Not every individual in society has equal access to the podium. Furthermore, power, being an inevitable feature of the public sphere, seems to permanently endanger its democratic value. Moreover, the existence of this sphere depends on a specific ethos and particular public spaces where citizens are called upon to present themselves as citizens, as people taking responsibility for their society. It is not clear whether this ethos and these spaces exist at all, and if so, if they preserved their ascribed capacity for constituting ‘democratic’ truth? By answering these questions we expect to deepen our understanding of the relation between truth and democracy.

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This volume discusses the latest approaches used to investigate molecular biology and physiology in the peripheral and central olfactory system. Understanding both normal function and pathobiology provides readers with insight into understanding human olfactory disorders. The chapters in this book cover topics such as techniques for manipulating and measuring olfactory cilia function; approaches for investigating spatial RNA expression in olfactory mucosa; the use of chromatin immunoprecipitation with olfactory neurons; in vivo methods to label and identify activated olfactory neurons; defining organization in the olfactory bulbs and cortex; and the use of optical recording in the mouse olfactory bulb for acute or chronic experiments. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Thorough and cutting-edge, The Olfactory System: Methods and Protocols is a valuable resource for all researchers who are interested in learning more about this important and developing field.

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This volume explores the latest techniques used by researchers to study directed evolution (DE) at each stage of the Design-Build-Test-Learn cycle. Chapters in this book cover topics such as designing overlap extension PCR primers for protein mutagenesis; antha-guided automation of Darwin assembly for the construction of bespoke gene libraries; rapid cloning of random mutagenesis libraries using PTO-Quickstep; and DE of glycosyltransferases by a single-cell screening method. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Directed Evolution: Methods and Protocols is a valuable resource for scientists and researchers who are interested in learning more about this field and incorporating these studies into new experimental workflows.

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This volume details the inventory and characterizes traditional meat products within each geographic region. Consisting of 21 chapters, chapters guide readers through comprehensive descriptions of the materials and processing conditions used to make each meat product so that it can be manufactured by other researchers or industries. In addition, each book chapter includes explanatory notes and elucidate the possible specific points to take into account for the correct manufacture. Authoritative and cutting-edge, Production of Traditional Mediterranean Meat Products aims to standardize the manufacturing process of the main Mediterranean traditional meat products, since there are several variations between manufacturers or regions.

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This thorough book collects methods and strategies to analyze proteomics data. It is intended to describe how data obtained by gel-based or gel-free proteomics approaches can be inspected, organized, and interpreted to extrapolate biological information. Organized into four sections, the volume explores strategies to analyze proteomics data obtained by gel-based approaches, different data analysis approaches for gel-free proteomics experiments, bioinformatic tools for the interpretation of proteomics data to obtain biological significant information, as well as methods to integrate proteomics data with other omics datasets including genomics, transcriptomics, metabolomics, and other types of data. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detailed implementation advice that will ensure high quality results in the lab. Authoritative and practical, Proteomics Data Analysis serves as an ideal guide to introduce researchers, both experienced and novice, to new tools and approaches for data analysis to encourage the further study of proteomics.Chapter 16 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

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This edition details a collection of specific shotgun proteomics-based laboratory techniques and applications developed in leading laboratories and proteomics units worldwide. Chapters cover a broad range of topics covering, shotgun proteomics of extracellular vesicles and subcellular structures, shotgun proteomics in non-model organisms, clinical proteomics, food proteomics, analysis of post-translational modifications and protein complexes, and data processing and storage. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Shotgun Proteomics: Methods and Protocols aims to be an up-to-date guide for researchers seeking to understand the proteome of any given biological sample.

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A development of the basic theory and applications of mechanics with an emphasis on the role of symmetry. The book includes numerous specific applications, making it beneficial to physicists and engineers. Specific examples and applications show how the theory works, backed by up-to-date techniques, all of which make the text accessible to a wide variety of readers, especially senior undergraduates and graduates in mathematics, physics and engineering. This second edition has been rewritten and updated for clarity throughout, with a major revamping and expansion of the exercises. Internet supplements containing additional material are also available.

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At last: geometry in an exemplary, accessible and attractive form! The authors emphasise both the intellectually stimulating parts of geometry and routine arguments or computations in concrete or classical cases, as well as practical and physical applications. They also show students the fundamental concepts and the difference between important results and minor technical routines. Altogether, the text presents a coherent high school curriculum for the geometry course, naturally backed by numerous examples and exercises.

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Skin cancer is among the most commonly occurring cancers, with incidence rates climbing among patients of all ages. The nose is the most common site for these cases. The vast majority of skin cancers of the nose are treated surgically by plastic surgeons, dermatologists, and otolaryngologists. Surgical excision requires reconstruction to one degree or another and Principles of Nasal Reconstruction will prove extremely helpful to any surgeon contemplating reconstruction of defects resulting from skin cancer removal. This book offers multiple guided surgical techniques and references to provide insight and practical guidance to the surgeon and trainee performing nasal reconstructions

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Electron backscatter diffraction is a very powerful and relatively new materials characterization technique aimed at the determination of crystallographic texture, grain boundary character distributions, lattice strain, phase identification, and much more. The purpose of this book is to provide the fundamental basis for electron backscatter diffraction in materials science, the current state of both hardware and software, and illustrative examples of the applications of electron backscatter diffraction to a wide-range of materials including undeformed and deformed metals and alloys, ceramics, and superconductors. The text has been substantially revised from the first edition, and the authors have kept the format as close as possible to the first edition text. The new developments covered in this book include a more comphrensive coverage of the fundamentals not covered in the first edition or other books in the field, the advances in hardware and software since the first edition was published, and current examples of application of electron backscatter diffraction to solve challenging problems in materials science and condensed-matter physics.

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Biology and Ecology of Earthworms is established as a key valuable text for students of agriculture, soil science, and soil invertebrate zoology and ecology. This is the 4th Edition of the popular textbook which reviews all aspects of earthworm biology and ecology. The book has been fully revised and updated throughout. Particular changes include: new treatments of earthworm taxonomy, diversity, migration and geographical distribution; interactions between earthworms and other soil organisms, especially microorganisms and soil-borne pests and diseases; as well as the importance of earthworms in organic waste management.

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In this well-written presentation, motivated by numerous examples and problems, the authors introduce the basic theory of braid groups, highlighting several definitions that show their equivalence; this is followed by a treatment of the relationship between braids, knots and links. Important results then treat the linearity and orderability of the subject. Relevant additional material is included in five large appendices. Braid Groups will serve graduate students and a number of mathematicians coming from diverse disciplines.

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Neural networks are members of a class of software that have the potential to enable intelligent computational systems capable of simulating characteristics of biological thinking and learning. Currently no standards exist to verify and validate neural network-based systems. NASA Independent Verification and Validation Facility has contracted the Institute for Scientific Research, Inc. to perform research on this topic and develop a comprehensive guide to performing V&V on adaptive systems, with emphasis on neural networks used in safety-critical or mission-critical applications. Methods and Procedures for the Verification and Validation of Artificial Neural Networks is the culmination of the first steps in that research. This volume introduces some of the more promising methods and techniques used for the verification and validation (V&V) of neural networks and adaptive systems. A comprehensive guide to performing V&V on neural network systems, aligned with the IEEE Standard for Software Verification and Validation, will follow this book.

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This book is intended to serve as an introduction to the pests of stored foodstuffs of all types on a worldwide basis, and as a broad reference text. It is aimed at being complementary to the more detailed and more specific texts that are listed in the References. It does presuppose an adequate basic knowledge of entomology and zoology in the user. The stored products mentioned in the text are commercial products in the widest sense, including all types of plant and animal materials in addition to grain and prepared foodstuffs. Storage is viewed very broadly, from one day on a shelf to several years in a silo, or refrigerated store at -20°C. In many publications the produce surveyed has been restricted to stored grains, because of their obvious importance to human society, and because of the great quantities involved. For many different materials, of both plant and animal origin, there is a shortage of specific information, but it is to be hoped that this situation will gradually be rectified. It should be clearly understood that any reference to animal pests is made in the strict zoological sense, and refers to any members of the Kingdom Animalia. There is a regrettable tendency in some circles to use the term ‘animal’ as being synonymous with ‘mammal’ – a habit to be deplored! There is definite emphasis on animal pests in this text, but micro-organisms are included where relevant.

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A self-contained introduction to probability, exchangeability and Bayes’ rule provides a theoretical understanding of the applied material. Numerous examples with R-code that can be run "as-is" allow the reader to perform the data analyses themselves. The development of Monte Carlo and Markov chain Monte Carlo methods in the context of data analysis examples provides motivation for these computational methods.

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From the reviews: "… The notes and problems at the end of each chapter are very helpful. […] In the final analysis, the book is definitely worth owning. […] It is an extremely well written – but unusual – book that I highly recommend for all physicists." The Physics Teacher

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There are many distinct pleasures associated with computer programming. Craftsmanship has its quiet rewards, the satisfaction that comes from building a useful object and making it work. Excitement arrives with the flash of insight that cracks a previously intractable problem. The spiritual quest for elegance can turn the hacker into an artist. There are pleasures in parsimony, in squeezing the last drop of performance out of clever algorithms and tight coding. The games, puzzles, and challenges of problems from international programming competitions are a great way to experience these pleasures while improving your algorithmic and coding skills. This book contains over 100 problems that have appeared in previous programming contests, along with discussions of the theory and ideas necessary to attack them. Instant online grading for all of these problems is available from two WWW robot judging sites. Combining this book with a judge gives an exciting new way to challenge and improve your programming skills. This book can be used for self-study, for teaching innovative courses in algorithms and programming, and in training for international competition. The problems in this book have been selected from over 1,000 programming problems at the Universidad de Valladolid online judge. The judge has ruled on well over one million submissions from 27,000 registered users around the world to date. We have taken only the best of the best, the most fun, exciting, and interesting problems available.

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From a review of the second edition:"This book covers many interesting topics not usually covered in a present day undergraduate course, as well as certain basic topics such as the development of the calculus and the solution of polynomial equations. The fact that the topics are introduced in their historical contexts will enable students to better appreciate and understand the mathematical ideas involved...If one constructs a list of topics central to a history course, then they would closely resemble those chosen here."(David Parrott, Australian Mathematical Society)This book offers a collection of historical essays detailing a large variety of mathematical disciplines and issues; it’s accessible to a broad audience. This third edition includes new chapters on simple groups and new sections on alternating groups and the Poincare conjecture. Many more exercises have been added as well as commentary that helps place the exercises in context.

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In this cleverly conceived book, physicist Robert Gilmore makes accessible some complex concepts in quantum mechanics by sending Alice to Quantumland-a whole new Wonderland, smaller than an atom, where each attraction demonstrates a different aspect of quantum theory. Alice unusual encounters, enhanced by illustrations by Gilmore himself, make the Uncertainty Principle, wave functions, the Pauli Principle, and other elusive concepts easier to grasp.

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This book describes the important ideas in a variety of fields such as medicine, biology, finance, and marketing in a common conceptual framework. While the approach is statistical, the emphasis is on concepts rather than mathematics. Many examples are given, with a liberal use of colour graphics. It is a valuable resource for statisticians and anyone interested in data mining in science or industry. The book's coverage is broad, from supervised learning (prediction) to unsupervised learning. The many topics include neural networks, support vector machines, classification trees and boosting---the first comprehensive treatment of this topic in any book. This major new edition features many topics not covered in the original, including graphical models, random forests, ensemble methods, least angle regression & path algorithms for the lasso, non-negative matrix factorisation, and spectral clustering. There is also a chapter on methods for "wide'' data (p bigger than n), including multiple testing and false discovery rates.

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Optimization is an important tool used in decision science and for the analysis of physical systems used in engineering. One can trace its roots to the Calculus of Variations and the work of Euler and Lagrange. This natural and reasonable approach to mathematical programming covers numerical methods for finite-dimensional optimization problems. It begins with very simple ideas progressing through more complicated concepts, concentrating on methods for both unconstrained and constrained optimization.

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This book disseminates current information pertaining to the modulatory effects of foods and other food substances on behavior and neurological pathways and, importantly, vice versa. This ranges from the neuroendocrine control of eating to the effects of life-threatening disease on eating behavior. The importance of this contribution to the scientific literature lies in the fact that food and eating are an essential component of cultural heritage but the effects of perturbations in the food/cognitive axis can be profound. The complex interrelationship between neuropsychological processing, diet, and behavioral outcome is explored within the context of the most contemporary psychobiological research in the area. This comprehensive psychobiology- and pathology-themed text examines the broad spectrum of diet, behavioral, and neuropsychological interactions from normative function to occurrences of severe and enduring psychopathological processes.

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This book covers issues of men’s health, including screening, diagnosis and management of common disorders and opportunities for prevention and health maintenance. Each chapter pertains to a component of the physical exam and/or organ system. Examples include appropriate survey and screening of the integument, the significance of buccal/dental integrity, tailoring cardiovascular remedies and balancing prostate cancer screening with quality of life. The book follows the methodical approach of a comprehensive wellness visit, including inventory of psychosocial factors, which significantly impact physical well-being. Justification for often overlooked topics in the review of systems, such as sexual history and satisfaction, relationship issues, and vocational fulfillment are provided. This book is written in the spirit of the rich bedside acumen and the art of healing, we must strive to protect. While informative and stimulating, this text serves to remind us of the specialized diagnostic tools we carry between our ears, and the power of healing we possess in our hands as well as the counsel and education we provide to our patients. Men’s Health: A Head to Toe Guide for Clinicians serves as an important and readily accessible resource for primary care physicians, internists and family doctors, physician’s assistants and nurse practitioners who care for adult males.

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​Fertility preservation has become one of the most important and fast growing fields of reproductive medicine. Although there are several strategies for fertility preservation in female, most of them are still considered experimental. It is important to perfect the existing technologies, but also developing new strategies should be actively sought. The future development of fertility preservation strategies should be based on the sound scientific knowledge and principles. One of the main objectives of fertility preservation in females is prevention of oocyte depletion. The mechanisms of oocyte loss and survival in the ovary are complex, which include genetic control both in germ cells and in somatic cells, DNA damage and repair mechanism, apoptosis and autophagy, and other poorly understood molecular mechanisms. To develop clinically effective and safe strategies for fertility preservation, it is essential to know and understand the fundamentals of oocyte and ovarian biology at the molecular level. Thus, the purpose of this edition is to review the current progress in research related to molecular and genetic control of oocyte development that can be applied to fertility preservation. The main topics that are discussed in this publication include molecular signaling mechanisms of oocyte activation and loss, genomic integrity of oocytes, and epigenetics.​

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This new edition emphasizes the unique contribution of this longstanding text in the integration of mind/body relationships. The concept of stress, as defined and elaborated in Chapter 1, the primary efferent biological mechanisms of the human stress response, as described in Chapter 2, and the link from stress arousal to disease, as defined in Chapter 3, essentially remains the same. However, updates in microanatomy, biochemistry and tomography are added to these chapters. All other chapters will be updated as well, as there has been significant changes in the field over the past eight years.

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Calculus Without Derivatives expounds the foundations and recent advances in nonsmooth analysis, a powerful compound of mathematical tools that obviates the usual smoothness assumptions. This textbook also provides significant tools and methods towards applications, in particular optimization problems. Whereas most books on this subject focus on a particular theory, this text takes a general approach including all main theories. In order to be self-contained, the book includes three chapters of preliminary material, each of which can be used as an independent course if needed. The first chapter deals with metric properties, variational principles, decrease principles, methods of error bounds, calmness and metric regularity. The second one presents the classical tools of differential calculus and includes a section about the calculus of variations. The third contains a clear exposition of convex analysis.

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Certain magnetic materials have optical properties that make them attractive for a wide variety of applications such as optical switches. This book describes the physics of one class of such magnetooptic materials, the insulating antiferromagnets. The authors summarize recent results concerning the structure, optical properties, spectroscopy, and magnetooptical properties of these materials. In particular, they consider magnetic phase transitions, symmetry effects, the linear magnetooptical effect, magnons, spectroscopic study of spin waves, photoinduced magnetic effects, and the effects of impurities.

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Superseding Gardiner's "Combustion Chemistry", this is an updated, comprehensive coverage of those aspects of combustion chemistry relevant to gas-phase combustion of hydrocarbons. The book includes an extended discussion of air pollutant chemistry and aspects of combustion, and reviews elementary reactions of nitrogen, sulfur and chlorine compounds that are relevant to combustion. Methods of combustion modeling and rate coefficient estimation are presented, as well as access to databases for combustion thermochemistry and modeling.

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Talking to patients and their families about end-of-life issues can be difficult and stressful. This book looks at ways different cultures view death and then further explores how health care providers around the world communicate about such sensitive issues as withholding or withdrawing life support and discussing options when the outcome is uncertain. By offering a better understanding of cultural differences in attitudes about death and methods of communications about end-of-life issues, the coverage in this important book helps prepare healthcare practitioners to be better communicators – both within and outside of their own cultures.

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As the Baby Boom generation ages, an increased need for geriatric specialty care becomes particularly important. This shift will especially affect ophthalmology, as the occurrence of common visual disorders such as cataracts, macular degeneration, glaucoma and diabetic retinopathy increases with age. This book anticipates this pending and inevitable demographic shift and fulfills the need for a practical, "bread-and-butter" approach to Geriatric Ophthalmology.

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Almost ?fteen years later, and there is little change in our motivation. Mathem- ical physics of quantum systems remains a lively subject of intrinsic interest with numerous applications, both actual and potential. Intheprefacetothe?rsteditionwehavedescribedtheoriginofthisbookrooted at the beginning in a course of lectures. With this fact in mind, we were naturally pleased to learn that the volume was used as a course text in many points of the world and we gladly accepted the o?er ofSpringer Verlag which inherited the rights from our original publisher, to consider preparation of a second edition. It was our ambition to bring the reader close to the places where real life dwells, and therefore this edition had to be more than a corrected printing. The ?eld is developing rapidly and since the ?rst edition various new subjects have appeared; as a couple of examples let us mention quantum computing or the major progress in theinvestigationofrandomSchr. odingeroperators.Thereare,however,goodsources intheliteraturewherethereadercanlearnabouttheseandothernewdevelopments.

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This book explores the relationship between neo-liberalism, state power and global governance, exploring national differences in the exercise of state power in a variety of industrialized and developing economies. Among the strengths of this volume are its detailed global scope, its range of case studies in diverse policy areas, its analysis and critique of neo-liberalism, in theory and practice, and its impact upon state power and global governance.

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Fatigue of structures and materials covers a wide scope of different topics. The purpose of the present book is to explain these topics, to indicate how they can be analyzed, and how this can contribute to the designing of fatigue resistant structures and to prevent structural fatigue problems in service. Chapter 1 gives a general survey of the topic with brief comments on the signi?cance of the aspects involved. This serves as a kind of a program for the following chapters. The central issues in this book are predictions of fatigue properties and designing against fatigue. These objectives cannot be realized without a physical and mechanical understanding of all relevant conditions. In Chapter 2 the book starts with basic concepts of what happens in the material of a structure under cyclic loads. It illustrates the large number of variables which can affect fatigue properties and it provides the essential background knowledge for subsequent chapters. Different subjects are presented in the following main parts: • Basic chapters on fatigue properties and predictions (Chapters 2–8) • Load spectra and fatigue under variable-amplitude loading (Chapters 9–11) • Fatigue tests and scatter (Chapters 12 and 13) • Special fatigue conditions (Chapters 14–17) • Fatigue of joints and structures (Chapters 18–20) • Fiber-metal laminates (Chapter 21) Each chapter presents a discussion of a speci?c subject.

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This book looks at the sources and composition of the atmosphere and rainfall, with particular attention on acidifying components and those that affect ecosystems. It further widens the subject to look at trace metals. It includes papers on the impact of deposition on soils and forests and the recovery of the natural environment. Work on critical loads makes a contribution to understanding the degree to which deposition must be reduced to limit its impact.

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