Search results for ""author kenneth"

The broad range of G protein-coupled receptors (GPCRs) encompasses all areas of modern medicine and have an enormous impact on the process of drug development. Using disease-oriented methods to cover everything from screening to expression and crystallization, G Protein-Coupled Receptors in Drug Discovery describes the physiological roles of GPCRs and their involvement in various human diseases.The book presents current approaches in drug discovery that include target selection, establishment of screening and functional assays. It also covers recombinant GPCR expression for drug screening and structural biology, different methods for structural characterization of GPCRs, and the importance of bioinformatics. The book has been carefully edited to avoid overlapping information, some duplication has been intentionally permitted so that each chapter can function as an independent unit. Providing in-depth discussions on structure and dynamics of GPCRs, this book outlines the importance of the GPCRs to drug discovery in general and drug targets specifically.Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.

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A timely guide to uncovering financial fraud 2008 and 2009 will be remembered for bear markets, a global credit crunch, and some of the largest investment scams ever. But these scams are nothing new, they've been repeated throughout history, and there will certainly be more to come. But the good news is fraudsters often follow the same basic playbook. Learn the playbook, and know how to ask the right questions, and financial fraud can be easy to detect and simple to avoid. In How to Smell a Rat, trusted financial expert Ken Fisher provides you with an inside's view on how to spot financial disasters before you become a part of them. Filled with in-depth insights and practical advice, this reliable resource takes an engaging look at recent and historic examples of fraudsters, how they operated, and how they can be easily avoided. Fisher also shows you the quick, identifiable features of financial frauds and arms you with the questions to ask when assessing a money manager. Prepares you to identify and avoid financials cams that could instantly destroy your wealth Contains examples that highlight how financial frauds are committed Provides questions everyone should ask before entering any investment endeavor With How to Smell a Rat as your guide, you'll learn how to protect your interests and assets from unnecessary losses.

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Legendary money manager Ken Fisher outlines the most common—and costly—mistakes investors make. Small cap stocks are best for all time. Bunk! A trade deficit is bad for markets. Bunk! Stocks can't rise on high unemployment. Bunk! Many investors think they are safest following widely accepted Wall Street wisdom—but much of Wall Street wisdom isn't so wise. In fact, it can be costly bunk. In Debunkery: Learn It, Do It, and Profit From It—Seeing Through Wall Street's Money-Killing Myths, Ken Fisher—named one of the 30 most influential individuals of the last three decades by Investment Advisor magazine—details why so many investors fail to get the long-term results they desire. The short answer is many investors fail to question if what they believe is true—and are therefore blinded by tradition, biases, ideology, or any number of cognitive errors. Your goal as an investor shouldn't be to be error-free—that's impossible. Rather, to be more successful, you should aim to lower your error rate. Debunkery gets you started by debunking 50 common myths—but that's just the beginning. It also gives you the tools you need to continue to do your own debunkery for the rest of your investing career.

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With its dignified courthouse set among shade trees and lawns dotted with monuments to prominent citizens and fallen veterans, the courthouse square remains the civic center in a majority of the county seats of Texas. Yet the squares themselves vary in form and layout, reflecting the different town-planning traditions that settlers brought from Europe, Mexico, and the United States. In fact, one way to trace settlement patterns and ethnic dispersion in Texas is by mapping the different types of courthouse squares.This book offers the first complete inventory of Texas courthouse squares, drawn from extensive archival research and site visits to 139 of the 254 county seats. Robert Veselka classifies every existing plan by type and origin, including patterns and variants not previously identified. He also explores the social and symbolic functions of these plans as he discusses the historical and modern uses of the squares. He draws interesting new conclusions about why the courthouse square remains the hub of commercial and civic activity in the smaller county seats, when it has lost its prominence in others.

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Since 2000, there has been an exponential amount of research completed in the field of transport modelling thereby creating a need for an expanded and revised edition of this book. National transport models have taken on the new modelling methods and there have been theoretical and empirical advances in performance measurement. Coverage will include current demand methods, data issues, valuation, cost and performance, and updated traffic models. Supplementary case studies will illustrate how modelling can be applied to the study of the different transport modes and the infrastructures that support them.The second edition of this handbook will continue to be an essential reference for researchers and practitioners in the field. All contributions are by leading experts in their fields and there is extensive cross-referencing of subject matter. This book features expanded coverage on emerging trends and updated case studies. It addresses models for specific applications (i.e. parking, national traffic forecasting, public transport, urban freight movements, and logistics management).

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This book discusses transport systems and the implementation of related public policy - a relevant topic with contemporary traffic congestion, environmental intrusion, transport safety, and budget issues. It is a resource for both experienced researchers and those new to the field.

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Approach your exams with confidence using Review Questions in Ophthalmology , Third Edition. You’ll find a concise review of all specialty rotations in ophthalmology, plus key areas such as embryology, anatomy, pediatrics, plastics, and lenses. Real-life clinical cases and more than 1,000 multiple choice questions with answers and explanations in this comprehensive review of ophthalmology provide core knowledge for all residents and fellows in ophthalmology, preparing you for success – both on your exams and in your practice! Test yourself with 1,000+ multiple choice questions, including answers and explanations. Clearly visualize what you’re likely to see on exams and in practice, thanks to more than 400 clinical photographs, fluorescein angiograms, and CT, MRI, and ultrasound images. Focus on common diseases for more useful self-assessment and real-life clinical preparation. LWW’s Online Resources for review content is all housed on ThePoint, which provides flexible learning solutions and resources using Review Questions in Ophthalmology, 3rd Edition. Test yourself with 1,000+ multiple choice questions, including answers and explanations. More than 400 clinical images (including photographs, fluorescein angiograms, and CT, MRI, and ultrasound images) Complete content for easy navigation

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Take papercraft to a new creative level and turn your home into a designer haven with this mindful DIY interiors book by Dutch design duo Studio Snowpuppe. Learn how to create 20 items of functional home decor - using simple, origami-inspired paper folding and manipulation techniques, and then show off your DIY creations at the heart of your home. Step-by-step illustrations will guide you through the projects, which include beautiful lampshades, creative wall art ideas, an ingenious clock, pretty decorations, coasters, vases, picture frames and more - all with a stylish modern aesthetic. Using readily available paper and card stock, you can create some stunning designer accents for your home for a fraction of the cost of store-bought versions.

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Paths to Wealth through Common Stocks contains one original concept after another, each designed to greatly improve the results of those who self-manage their investments -- while helping those who rely on professional investment advice select the right advisor for their needs. Originally written by investment legend Philip A. Fisher in 1960, this timeless classic is now reintroduced by his well-known and respected son, successful money manager Ken Fisher, in a new Foreword. Filled with in-depth insights and expert advice, Paths to Wealth through Common Stocks expands upon the innovative ideas found in Fisher's highly regarded Common Stocks and Uncommon Profits -- summarizing how worthwhile profits have been and will continue to be made through common stock ownership, and revealing why his method can increase profits while reducing risk. Many of the ideas found here may depart from conventional investment wisdom, but the impressive results produced by these concepts -- which are still relevant in today's market environment -- will quickly remind you why Philip Fisher is considered one of the greatest investment minds of our time.

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Volume 13, Advances in Business and Management Forecasting, is a blind refereed serial publication. It presents state-of-the-art studies in the application of forecasting methodologies to such areas as sales forecasting, retailing, service contracts, bankruptcy prediction, executive compensation, and call center staffing. The orientation of this volume is for business applications for both the researcher and the practitioner of forecasting. Volume 13 is divided into three sections: Marketing, Sales and Service Forecasting; Economic, Financial and Insurance Forecasting; and, CEO Compensation and Operations Forecasting. An interdisciplinary group of experts explore wide-ranging topics including omnichannel retailing, growth business cycles, under-resampling methods to detect non-injured passengers within car accidents and regression modeling of CEO compensation.

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Over the past fifteen years, The Spread of Nuclear Weapons has been a staple in International Relations courses because of its brevity and crystal-clear explanations. The new edition, An Enduring Debate, continues the important discussion of nuclear proliferation and the dangers of a nuclear-armed world. With new chapters on the questions surrounding a nuclear North Korea, Iran, and Iraq and the potential for a world free of nuclear weapons, this Third Edition will continue to generate a lively classroom experience.

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This two volume collection of pioneering material includes landmarks and significant contributions to the subjects of global environmental issues. The editors have prepared a new introduction for this authoritative collection.This collection enables the reader, whether an economist or environmentalist, to have access to material published in a wide range of journals, many of which are relatively unavailable. It will be of considerable value to researchers and teachers in all of the disciplines, including: theoretical ecology; resource and environmental economics; industrial ecology and environmental science.

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This outstanding new collection surveys the relationship between the environment and development, and highlights some of the tensions that are implicit in the notion of sustainable development.Environmental Economics and Development is organized into six sections: general aspects; resource utilization and management; valuation and accounting of environmental change; environmental policy instruments; adjustment, trade and the environment; and distributional issues. These areas include general features of environment-development interfaces, operational valuation and accounting methods and economic approaches to environmental policy instruments in developing countries and in the international context.

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75 unique designs for attractive, efficient, environmentally friendly homes. Now available in paperback, this collection of 75 plans for small homes offers more than 500 usable blueprints and other illustrations for a variety of living spaces suitable for every environment and style, from a New England farmhouse to a sophisticated townhouse in the city to a Santa Fe ranch. The designs include site drawings, floor plans, elevation drawings, section drawings, perspective drawings, and exploded views. A brief introduction to each home describes its setting, the philosophy behind the design and its intended use, materials used, recommended landscaping, and more. Many of the homes come with money-saving and environmentally sound features such as solar panels and water heaters, wood stoves, ceiling fans, airlock entries, wind power alternatives, and natural gas heaters.

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This innovative book helps K-6 teachers infuse the entire school day with research-based literacy best practices. Classroom-tested strategies are presented for planning and implementing each component of the "exemplary literacy day"--vocabulary and word study sessions, literacy work stations, differentiated guided reading groups, reading and writing workshops, and interdisciplinary projects. Teachers get tips for organizing a print-rich classroom, supporting students' social–emotional well-being, and using assessment to guide instruction. User-friendly features include vivid vignettes, classroom management tips, questions for discussion and reflection, and 15 reproducible forms, checklists, and lesson templates. Purchasers get access to a Web page where they can download and print the reproducible materials in a convenient 8 1/2" x 11" size. Note: this book is a contemporary follow-up to Morrow's influential earlier title Organizing and Managing the Language Arts Block.

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Aircraft Control Allocation An authoritative work on aircraft control allocation by its pioneers Aircraft Control Allocation addresses the problem of allocating redundant flight controls. It provides introductory material on flight dynamics and control to provide the context, and then describes in detail the geometry of the problem. The book includes a large section on solution methods, including ‘Banks’ method’, a previously unpublished procedure. Generalized inverses are also discussed at length. There is an introductory section on linear programming solutions, as well as an extensive and comprehensive appendix on linear programming formulations and solutions. Discrete-time or ‘frame-wise’ allocation is described, including rate-limiting, nonlinear data, and preferred solutions. Key features: Written by pioneers in the field of control allocation Comprehensive explanation and discussion of the major control-allocation solution methods Extensive treatment of linear programming solutions to control allocation A companion web site contains the code of a MATLAB/Simulink light simulation with modules that incorporate all of the major solution methods Includes examples based on actual aircraft The book is a vital reference for researchers and practitioners working in aircraft control, as well as graduate students in aerospace engineering.

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“We traveled this forenoon over the roughest and most desolate piece of ground that was ever made,” wrote Amelia Knight during her 1853 wagon train journey to Oregon. Some of the parties who traveled with Knight were propelled by religious motives. Hannah King, an Englishwoman and Mormon convert, was headed for Salt Lake City. Her cultured, introspective diary touches on the feelings of sensitive people bound together in a stressful undertaking. Celinda Hines and Rachel Taylor were Methodists seeking their new Canaan in Oregon. Also Oregon-bound in 1853 were Sarah (Sally) Perkins, whose minimalist record cuts deep, and Eliza Butler Ground and Margaret Butler Smith, sisters who wrote revealing letters after arriving. Going to California in 1854 were Elizabeth Myrick, who wrote a no-nonsense diary, and the teenage Mary Burrell, whose wit and exuberance prevail.

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Surdas has been regarded as the epitome of artistry in Old Hindi religious poetry from the end of the sixteenth century, when he lived, to the present day. His fame rests upon his remarkable refashioning of the widely known narrative of the cowherd deity Krishna and his lover Radha into lyrics that are at once elegant and approachable. Surdas’s popularity led to the proliferation, through an energetic oral tradition, of poems ascribed to him, known as the Sūrsāgar.Sur’s Ocean: Poems from the Early Tradition presents a dramatically new edition in Devanagari script and a lyrical English translation. This remarkable volume reconstructs the early tradition of Surdas’s verse—the 433 poems that were known to the singers of Surdas’s own time as his. Here Surdas stands out with a clarity never before achieved.The Murty Classical Library of India makes available original texts and modern English translations of the masterpieces of literature and thought from across the whole spectrum of Indic languages over the past two millennia in the most authoritative and accessible formats on offer anywhere.

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Written for the full year or three term Calculus-based University Physics course for science and engineering majors, the publication of the first edition of Physics in 1960 launched the modern era of Physics textbooks. It was a new paradigm at the time and continues to be the dominant model for all texts. Physics is the most realistic option for schools looking to teach a more demanding course.

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Moscow in the middle of the seventeenth century had a distinctly apocalyptic feel. An outbreak of the plague killed half the population. A solar eclipse and comet appeared in the sky, causing panic. And a religious reform movement intended to purify spiritual life and provide for the needy had become a violent political project that cleaved Russian society and the Orthodox Church in two. The autobiography of Archpriest Avvakum—a leader of the Old Believers, who opposed liturgical and ecclesiastical reforms—provides a vivid account of these cataclysmic events from a figure at their center.Written in the 1660s and ’70s from a cell in an Arctic village where the archpriest had been imprisoned by the tsar, Avvakum’s autobiography is a record of his life, ecclesiastical career, painful exile, religious persecution, and imprisonment. It is also a salvo in a contest about whether to follow the old Russian Orthodox liturgy or import Greek rites and practices. These concerns touched every stratum of Russian society—and for Avvakum, represented an urgent struggle between good and evil.Avvakum’s autobiography has been a cornerstone of Russian literature since it first circulated among religious dissidents. One of the first Russian-language autobiographies and works of any sort to make use of colloquial Russian, its language and style served as a model for writers such as Tolstoy, Dostoevsky, and Gorky. The Life Written by Himself is not only an important historical document but also an emotionally charged and surprisingly conversational self-portrait of a crucial figure in a tumultuous time.

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Alain Badiou is perhaps the world’s most significant living philosopher. In his annual seminars on major topics and pivotal figures, Badiou developed vital aspects of his thinking on a range of subjects that he would go on to explore in his influential works. In this seminar, Badiou offers a tour de force encounter with a lesser-known seventeenth-century philosopher and theologian, Nicolas Malebranche, a contemporary and peer of Spinoza and Leibniz.The seminar is at once a record of Badiou’s thought at a key moment in the years before the publication of his most important work, Being and Event, and a lively interrogation of Malebranche’s key text, the Treatise on Nature and Grace. Badiou develops a rigorous yet novel analysis of Malebranche’s theory of grace, retracing his claims regarding the nature of creation and the relation between God and world and between God and Jesus. Through Malebranche, Badiou develops a radical concept of truth and the subject. This book renders a seemingly obscure post-Cartesian philosopher fascinating and alive, restoring him to the philosophical canon. It occupies a pivotal place in Badiou’s reflections on the nature of being that demonstrates the crucial role of theology in his thinking.

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The Human Tradition in Premodern China is a collection of biographical essays revealing the variety and complexity of human experience in China from the earliest historical times to the dawn of the modern age. China is a vast country with a long history, and one which is by itself as complex as the history of Europe. This broad expanse of time and space in Chinese history has largely been approached in terms of narrative political and cultural history in most books. The reigns of emperors and the thoughts of the great masters such as Confucius or Laozi have been the principal focus. Yet the history of the Chinese, as with any great people, is built up from the lives of individuals, families, groups, and movements. By presenting life stories of individuals ranging from ancient court diviners to late imperial merchants to women in various periods, this engaging anthology highlights aspects of Chinese social, political and intellectual history not usually addressed. Additionally, The Human Tradition in Premodern China broadens the common image and understanding of society based on the dominant elite male discourse. Rich in new perspective and new scholarship, The Human Tradition in Premodern China is an ideal introduction to Chinese history, East Asian history, and world history.

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One of the most important works of twentieth-century British literature, The Good Soldier addresses the lives and interrelationships between two couples: one American, one British. A tragicomic novel of manners, in which John Dowell narrates the disintegration of both his own and another marriage, the work’s depiction of passion and intrigue offers an ironic reading of Edwardian-era values.The Broadview edition features the text of the first edition of the novel published by John Lane and The Bodley Head in 1915. It also includes: other writings by Ford Madox Ford (“On Heaven,” excerpts from Henry James: A Critical Study, “On Impressionism,” and “Techniques”); contemporary reviews; and Ezra Pound’s obituary of Ford Madox Ford.

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Voice and Communication Therapy for the Transgender/Gender Diverse Client: A Comprehensive Clinical Guide, Third Edition is the first resource of it's kind for speech-language pathologists and voice clinicians who assist transgender/gender diverse clients in developing authentic voices, language, and nonverbal communication congruous with their gender identification. Such challenges for both transfeminine and transmasculine people are far from insurmountable with proper training. This third edition builds on the work of the first two editions and provides for a larger and better informed core of speech language pathologists with the specialized skills to train transgender/gender diverse clients. Outstanding features include thorough background information on history, sociology, psychology, and medical terminology relevant to this population and the overall role of the voice therapist and speech-language pathologist in the transition of a transgender client. Chapters cover each aspect of a communication training program, including case studies, summaries, appendices and an extensive bibliography. New to this edition: *A PluralPlus companion website including "before and after" audio files of communication therapy examples *A new co-editor, Jack Pickering, brings a fresh perspective and decades of experience in transgender voice and communication *A chapter addressing the voice and communication needs of transmasculine individuals This text guides clinicians who work with the population in designing and administering a mindful, focused, and efficient treatment plan. Speech-language pathologists, ENT physicians, and professors within the areas of singing, theatre, and voice disorders will find this text to be a necessary resource.

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New insights into Picasso’s Blue Period, through innovative technology that reveals hidden compositions, motifs and alterations, plus hitherto unknown information on the artist's materials and process This lavishly illustrated volume reexamines Pablo Picasso’s famous Blue Period (1901–04) in paintings, works on paper and sculpture. Relying on new information gleaned from technical studies performed on The Blue Room (Le Tub) (1901), Crouching Beggarwoman (La Miséreuse accroupie) (1902) and The Soup (La Soupe) (1903), this multidisciplinary volume combines art history and advanced conservation science in order to show how the young Picasso fashioned a distinct style and a pronounced artistic identity as he adapted the artistic lessons of fin-de-siècle Paris to the social and political climate of an economically struggling Barcelona. Essays, a chronology and a summary of conservation findings contextualize Picasso’s experimental approach to painting during the Blue Period. A major contribution to the burgeoning field of technical art history, Picasso: Painting the Blue Period advances new scholarship on one of the most critical episodes in 20th-century modernism.

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Offering a broad exploration of the cultural history of democracy in the medieval age, this volume claims that, though not generally associated with the term, the Middle Ages deserve to be included in a general history of democracy. The term was never widely employed during this period, the dominant attitude towards democracy was outright hostility, and none of the medieval polities thought of itself as a democracy. Despite this, this study highlights a wide variety of ideas, practices, procedures, and institutions that, although different from their ancient predecessor (direct democracy) or modern successor (liberal representative democracy), played a significant role in the history of democracy. This volume covers almost 1,000 years and a wide range of territories. It deals with different political spheres (ecclesiastical and secular) and socio-political settings (courtly, urban, and rural) and examines the phenomenon from the local level up to the universal realm. This volume adopts a broad cultural approach and is structured thematically. Each chapter takes a theme as its focus: sovereignty; liberty and the rule of law; the common good; economic and social democracy; religion and the principles of political obligation; citizenship and gender; ethnicity, race, and nationalism; democratic crises, revolutions, and civil resistance; international relations; and the scalability of democracy beyond the limits of a single city. These ten themes add up to an extensive, synoptic coverage of the subject.

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A practitioner's guide to finding alpha in fixed income trading in emerging markets Emerging fixed income markets are both large and fast growing. China, currently the second largest economy in the world, is predicted to overtake the United States by 2030. Chinese fixed income markets are worth more than $11 trillion USD and are being added to global fixed income indices starting in 2019. Access for foreigners to the Indian fixed income market, valued at almost 1trn USD, is also becoming easier – a trend repeated in emerging markets around the world. The move to include large Emerging Market (EM) fixed income markets into non-EM benchmarks requires non-EM specialists to understand EM fixed income. Trading Fixed Income in Emerging Markets examines the principle drivers for EM fixed income investing. This timely guide suggests a more systematic approach to EM fixed income trading with a focus on practical trading rules on how to generate alpha, assisting EM practitioners to limit market-share losses to passive investment vehicles. The definitive text on trading EM fixed income, this book is heavily data-driven – every trading rule is thoroughly back-tested over the last 10+ years. Case studies help readers identify and benefit from market regularities, while discussions of the business cycle and typical EM events inform and optimise trading strategies. Topics include portfolio construction, how to apply ESG principles to EM and the future of EM investing in the realm of Big Data and machine learning. Written by practitioners for practitioners, this book: Provides effective, immediately-accessible tools Covers all three fixed income asset classes: EMFX, EM local rates and EM credit Thoroughly analyses the impact of the global macro cycle on EM investing Examines the influence of the financial rise of China and its fixed income markets Includes case studies of trades that illustrate how markets typically behave in certain situations The first book of its kind, Trading Fixed Income in Emerging Markets: A Practitioner’s Guide is an indispensable resource for EM fund managers, analysts and strategists, sell-side professionals in EM and non-EM specialists considering activity in emerging markets.

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A counting book in rhyme presents various marine animals and their children, from a mother manatee and her little calf one to a mother octopus and her little babies ten. Complete with a glossary, musical score, and numbers hidden in the illustrations.

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A newly updated, expanded edition of the most comprehensive one-volume reference work on New York City ever compiled Covering an exhaustive range of information about Manhattan, Brooklyn, Queens, the Bronx, and Staten Island, the first edition of The Encyclopedia of New York City was a success by every measure, earning worldwide acclaim and several awards for reference excellence, and selling out its first printing before it was officially published.But much has changed since the volume first appeared in 1995: the World Trade Center no longer dominates the skyline, a billionaire businessman became an unlikely three-term mayor, and urban regeneration—Chelsea Piers, the High Line, DUMBO, Williamsburg, the South Bronx, the Lower East Side—has become commonplace. To reflect such innovation and change, this definitive, one-volume resource on the city has been completely revised and expanded.The revised edition includes 800 new entries that help complete the story of New York: from Air Train to E-ZPass, from September 11 to public order. The new material includes broader coverage of subject areas previously underserved as well as new maps and illustrations. Virtually all existing entries—spanning architecture, politics, business, sports, the arts, and more—have been updated to reflect the impact of the past two decades.The more than 5,000 alphabetical entries and 700 illustrations of the second edition of The Encyclopedia of New York Cityconvey the richness and diversity of its subject in great breadth and detail, and will continue to serve as an indispensable tool for everyone who has even a passing interest in the American metropolis.

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Covers all the common trees, even nonnative ones that might not be found in other guides Species accounts for 130 trees found in cities, suburbs, small towns, neighborhoods, parks, and empty lots 213 color photos show leaves, flowers, fruits, and seeds Includes information about the history and uses of each tree

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The Story of the Stone (also known as Dream of the Red Chamber) is widely held to be the greatest work of Chinese literature, beloved by readers ever since it was first published in 1791. The story revolves around the young scion of a mighty clan who, instead of studying for the civil service examinations, frolics with his maidservants and girl cousins. The narrative is cast within a mythic framework in which the protagonist’s rebellion against Confucian strictures is guided by a Buddhist monk and a Taoist priest. Embedded in the novel is a biting critique of imperial China’s political and social system.This book is a straightforward guide to a complex classic that was written at a time when readers had plenty of leisure to sort through the hundreds of characters and half a dozen subplots that weave in and out of the book’s 120 chapters. Each chapter of the companion summarizes and comments on each chapter of the novel. The companion provides English-speaking readers—whether they are simply dipping into this novel or intent on a deep analysis of this masterpiece—with the cultural context to enjoy the story and understand its world.The book is keyed to David Hawkes and John Minford’s English translation of The Story of the Stone and includes an index that gives the original Chinese names and terms.

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When William Blackwood, George Eliot’s publisher, first saw the manuscript of Felix Holt in 1866 he could not contain his enthusiasm; in a letter to a friend he described the novel as “a perfect marvel. The time is 1832 just after the passing of the Reform Bill, and surely such a...series of pictures of English Life, manners, and conversation never was drawn. You see and hear the people speaking. Every individual character stands out a distinct figure.”A political radical and a child of the working class, Felix has lost faith in a political system in which candidates never represent the interests of the working class. Harold Transome, the cynical son of wealthy Tory landowners, embraces radical politics for very different reasons. Both Harold and Felix vie for the affections of Esther Lyon, and she must weigh her feelings for them with the social and material goals she has set for herself. Their personal drama unfolds against the broad canvas of social and political upheaval of 1830s England.This edition is based on the text of the first edition of the novel published in three volumes in 1866, and includes a full introduction, a wide range of appendices including reviews, as well as Eliot’s “Address to Working Men, by Felix Holt”; “The Legal Plot of Felix Holt”; and a chronology of Eliot’s life and career.

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A collaboration between some of the leading international experts in the field, AOCMF proudly presents Antiresorptive Drug-related Osteonecrosis of the Jaw (ARONJ)-a Guide to Research, which unravels the many biologic processes and risk factors associated with this debilitating condition. With its unknown pathophysiology, lack of established management regimens, and because of the millions of patients currently taking antiresorptive agents, this important book on ARONJ has been produced to provide the latest in contemporary evidence and insight. The book's key features include: Detailed analysis of the historical definitions, classifications, and clinical features of ARONJ Review of the risk factors and treatment options currently available, and why the jaw bone is predominantly affected Discussion on the use of large and small animals in modelling. With dozens of clinical images to help illustrate the impact of this condition on real patients, Antiresorptive Drug-related Osteonecrosis of the Jaw (ARONJ)-a Guide to Research is an excellent resource for anyone involved or interested in this important medical field.

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Economic Incentives are playing an increasingly important role in pollution control.This authoritative collection - edited by leading contributors to the field - presents the most important published work on the legal and economic instruments and institutions which have been used during the last thirty years to control pollution. The papers focus on issues of instrument design, implementation, enforcement and evaluation, and consider strategies for coping with uncertainty and 'second-best' situations.

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