Search results for ""springer-verlag new york inc.""

Airbreathing Propulsion covers the physics of combustion, fluid and thermo-dynamics, and structural mechanics of airbreathing engines, including piston, turboprop, turbojet, turbofan, and ramjet engines. End-of-chapter exercises allow the reader to practice the fundamental concepts behind airbreathing propulsion, and the included PAGIC computer code will help the reader to examine the relationships between the performance parameters of different engines. Large amounts of data have on many different piston, turbojet, and turboprop engines have been compiled for this book and are included as an appendix. This textbook is ideal for senior undergraduate and graduate students studying aeronautical engineering, aerospace engineering, and mechanical engineering.

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Mechanical Vibrations: Modeling and Measurement describes essential concepts in vibration analysis of mechanical systems. It incorporates the required mathematics, experimental techniques, fundamentals of model analysis, and beam theory into a unified framework that is written to be accessible to undergraduate students, researchers, and practicing engineers. To unify the various concepts, a single experimental platform is used throughout the text. Engineering drawings for the platform are included in an appendix. Additionally, MATLAB programming solutions are integrated into the content throughout the text.

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Biometric recognition, or simply biometrics, is the science of establishing the identity of a person based on physical or behavioral attributes. It is a rapidly evolving field with applications ranging from securely accessing one’s computer to gaining entry into a country. While the deployment of large-scale biometric systems in both commercial and government applications has increased the public awareness of this technology, "Introduction to Biometrics" is the first textbook to introduce the fundamentals of Biometrics to undergraduate/graduate students. The three commonly used modalities in the biometrics field, namely, fingerprint, face, and iris are covered in detail in this book. Few other modalities like hand geometry, ear, and gait are also discussed briefly along with advanced topics such as multibiometric systems and security of biometric systems. Exercises for each chapter will be available on the book website to help students gain a better understanding of the topics and obtain practical experience in designing computer programs for biometric applications. These can be found at: http://www.csee.wvu.edu/~ross/BiometricsTextBook/.Designed for undergraduate and graduate students in computer science and electrical engineering, "Introduction to Biometrics" is also suitable for researchers and biometric and computer security professionals.

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Proceedings from the first International Symposium on Primo Vascular System 2010 (ISPS 2010) with special topics on cancer and regeneration was held in Jecheon, Korea during September 17-18, 2010. Includes coverage of new study results that have better revealed the functional aspects of PVS, including its roles in the areas of regenerative medicine and cancer.

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The second edition of Gesser’s classic Applied Chemistry includes updated versions of the original 16 chapters plus two new chapters on semiconductors and nanotechnology. This textbook introduces chemistry students to the applications of their field to engineering design and function across a wide range of subjects, from fuels and polymers to electrochemistry and water treatment. Each chapter concludes with a reading list of relevant books and articles as well as a set of exercises which include problems that extend the topics beyond the text. Other supplements to the text include a laboratory section with step-by-step experiments and a solutions manual for instructors.

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107 with treatments that affect the arousal of the animals is also implied on the basis of the behavioral changes induced in the lesioned animals by amphetamine administration and by changes in the motivational circumstances under which the animals are tested. Studies of the effects of cingulate lesions in the rat have involved the production of midline cortical damage. Unfortunately, as reported in the previous chapter, the midline cortex of the rat is not comparable to the midline cortex of other animals as defined on the basis of the fibers it receives from the thalamus. In addition, lesions of the midline cortex, whether in the rat or in other species, are likely to interfere with fibers of the neural systems in or near it. These include the cingulum bundle and the supracallosal fibers of the fornix. Norepi­ nephrine-containing fibers also pass through this region in or near the cingulum bundle. These fibers ascend through the anterior dor­ solateral septal area and turn up and back to pass through the midline regions and innervate the entire medial cortex (Morrison, Molliver, & Grzanna, 1979). Lesions in this area reduce the norepinephrine distribution throughout the rostrocaudal extent of the medial cortex. A similar problem results from destruction to the anterior cortical regions. Lesions in that region could reduce the norepinephrine sup­ plies of the entire dorsolateral cortex.

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The book starts with dissecting mechanisms underlying viral immune evasion via exploiting the host complement system by vaccinia virus, and by modulating the type 1 interferon response by RNA viruses. Yet another chapter looks into how viroporins expressed by different families of viruses causing influenza A virus, SARS, hepatitis C and HIV interact with several cellular pathways. Understanding of these mechanisms can aid the development of novel potential anti‑viral targets. The chapter on tuberculosis discusses the emerging importance of the innate immune mechanisms against Mycobacterium tuberculosis infection and latency. This book has a strong focus on fungal pathogenesis and immunity, starting with virulence and host factors that attain great importance in candidiasis and associated escape tricks of seriously opportunistic fungi. Two chapters on Aspergillus fumigatus elaborate on the pathogenic mechanisms: first discussing A. fumigatus‑airway epithelium interaction, followed by fungal and host factors that are paramount in the development of allergic and invasive aspergillosis. In the subsequent chapter, there is a general discussion on the innate and adaptive immune responses against primary and opportunistic fungal pathogens.

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The contents of The R Software are presented so as to be both comprehensive and easy for the reader to use. Besides its application as a self-learning text, this book can support lectures on R at any level from beginner to advanced. This book can serve as a textbook on R for beginners as well as more advanced users, working on Windows, MacOs or Linux OSes. The first part of the book deals with the heart of the R language and its fundamental concepts, including data organization, import and export, various manipulations, documentation, plots, programming and maintenance. The last chapter in this part deals with oriented object programming as well as interfacing R with C/C++ or Fortran, and contains a section on debugging techniques. This is followed by the second part of the book, which provides detailed explanations on how to perform many standard statistical analyses, mainly in the Biostatistics field. Topics from mathematical and statistical settings that are included are matrix operations, integration, optimization, descriptive statistics, simulations, confidence intervals and hypothesis testing, simple and multiple linear regression, and analysis of variance. Each statistical chapter in the second part relies on one or more real biomedical data sets, kindly made available by the Bordeaux School of Public Health (Institut de Santé Publique, d'Épidémiologie et de Développement - ISPED) and described at the beginning of the book. Each chapter ends with an assessment section: memorandum of most important terms, followed by a section of theoretical exercises (to be done on paper), which can be used as questions for a test. Moreover, worksheets enable the reader to check his new abilities in R. Solutions to all exercises and worksheets are included in this book.

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The Handbook of Olive Oil presents an up-to-date view of all aspects of olive oil. It is written from an inter-disciplinary point of view and will be of use in research and development as well as in routine laboratory and process operations. This second edition includes new chapters devoted to genetic studies and agronomic aspects of new orchards and cultivars, which, in combination with the most recent biochemical studies and technological developments, explain the unique chemical composition of olive oil. The analytical aspects of the first edition are now described in six new chapters focused on the chemical compounds responsible for olive oil traceability and sensory perceptions (odor, color, and taste) utilizing chromatographic, spectroscopic, and in-tandem techniques. Nutritional and sensory aspects are the basis for the current success of virgin olive oil among consumers, and this new edition re-analyzes in two new chapters the role of lipids, in general, and olive oil, in particular, in nutrition and health. In addition, the methodologies developed for determining sensory quality, olive oil oxidation, and deep-frying are extensively described and discussed. The role of consumers in olive oil studies of marketing and acceptability is covered in a new chapter.This second edition has not ignored the fact that the popularity of olive oil has made it a preferred target for fraudsters. Deliberate mislabeling or mixtures containing less expensive edible oils are topics described in depth in two chapters devoted to traceability and adulteration. There is also a new chapter focused on the olive refining process, which is a relevant activity in the olive oil world, and another chapter displaying tables of chemical and sensory information from olive oils produced all over the world.The book is written at two levels: the main level is structured as a tutorial on the practical aspects of olive oil. A second, more methodological level, is intended for specialists in the different sciences that contribute to olive oil studies (biochemistry, chemistry, physics, statistics etc).This edition also details changes that are needed in different disciplines in order to overcome current problems and challenges.

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Over the last 50 years there have been an increasing number of applications of algebraic tools to solve problems in communications, in particular in the fields of error-control codes and cryptography. More recently, broader applications have emerged, requiring quite sophisticated algebra - for example, the Alamouti scheme in MIMO communications is just Hamilton's quaternions in disguise and has spawned the use of PhD-level algebra to produce generalizations. Likewise, in the absence of credible alternatives, the industry has in many cases been forced to adopt elliptic curve cryptography. In addition, algebra has been successfully applied to problems in signal processing such as face recognition, biometrics, control design, and signal design for radar. This book introduces the reader to the algebra they need to appreciate these developments and to various problems solved by these techniques.

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​​​​In the spring of 1976, George Andrews of Pennsylvania State University visited the library at Trinity College, Cambridge, to examine the papers of the late G.N. Watson. Among these papers, Andrews discovered a sheaf of 138 pages in the handwriting of Srinivasa Ramanujan. This manuscript was soon designated, "Ramanujan's lost notebook." Its discovery has frequently been deemed the mathematical equivalent of finding Beethoven's tenth symphony.This volume is the fourth of five volumes that the authors plan to write on Ramanujan’s lost notebook.​ In contrast to the first three books on Ramanujan's Lost Notebook, the fourth book does not focus on q-series. Most of the entries examined in this volume fall under the purviews of number theory and classical analysis. Several incomplete manuscripts of Ramanujan published by Narosa with the lost notebook are discussed. Three of the partial manuscripts are on diophantine approximation, and others are in classical Fourier analysis and prime number theory. Most of the entries in number theory fall under the umbrella of classical analytic number theory. Perhaps the most intriguing entries are connected with the classical, unsolved circle and divisor problems.Review from the second volume:"Fans of Ramanujan's mathematics are sure to be delighted by this book. While some of the content is taken directly from published papers, most chapters contain new material and some previously published proofs have been improved. Many entries are just begging for further study and will undoubtedly be inspiring research for decades to come. The next installment in this series is eagerly awaited."- MathSciNetReview from the first volume:"Andrews and Berndt are to be congratulated on the job they are doing. This is the first step...on the way to an understanding of the work of the genius Ramanujan. It should act as an inspiration to future generations of mathematicians to tackle a job that will never be complete."- Gazette of the Australian Mathematical Society​

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The Economics of Immigration is written as a both a reference for researchers and as a textbook on the economics of immigration. It is aimed at two audiences: (1) researchers who are interested in learning more about how economists approach the study of human migration flows; and (2) graduate students taking a course on migration or a labor economics course where immigration is one of the subfields studied. The book covers the economic theory of immigration, which explains why people move across borders and details the consequences of such movements for the source and destination economies. The book also describes immigration policy, providing both a history of immigration policy in a variety of countries and using the economic theory of immigration to explain the determinants and consequences of the policies. The timing of this book coincides with the emergence of immigration as a major political and economic issue in the USA, Japan Europe and many developing countries.

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An excellent introduction for all those coming to the subject for the first time.New material has been added to the second edition and the original six chapters have been modified.The previous edition sold 9500 copies world wide since its release in 1996.Based on numerous courses given by the author to students and researchers in the health sciences and is written with such readers in mind. Provides a "user-friendly" layout and includes numerous illustrations and exercises. Written in such a way so as to enable readers learn directly without the assistance of a classroom instructor. Throughout, there is an emphasis on presenting each new topic backed by real examples of a survival analysis investigation, followed up with thorough analyses of real data sets.

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The ?eld of sensory science has grown exponentially since the publication of the p- vious version of this work. Fifteen years ago the journal Food Quality and Preference was fairly new. Now it holds an eminent position as a venue for research on sensory test methods (among many other topics). Hundreds of articles relevant to sensory testing have appeared in that and in other journals such as the Journal of Sensory Studies. Knowledge of the intricate cellular processes in chemoreception, as well as their genetic basis, has undergone nothing less than a revolution, culminating in the award of the Nobel Prize to Buck and Axel in 2004 for their discovery of the olfactory receptor gene super family. Advances in statistical methodology have accelerated as well. Sensometrics meetings are now vigorous and well-attended annual events. Ideas like Thurstonian modeling were not widely embraced 15 years ago, but now seem to be part of the everyday thought process of many sensory scientists. And yet, some things stay the same. Sensory testing will always involve human participants. Humans are tough measuring instruments to work with. They come with varying degrees of acumen, training, experiences, differing genetic equipment, sensory capabilities, and of course, different preferences. Human foibles and their associated error variance will continue to place a limitation on sensory tests and actionable results. Reducing, controlling, partitioning, and explaining error variance are all at the heart of good test methods and practices.

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From a review of the second edition:"This book covers many interesting topics not usually covered in a present day undergraduate course, as well as certain basic topics such as the development of the calculus and the solution of polynomial equations. The fact that the topics are introduced in their historical contexts will enable students to better appreciate and understand the mathematical ideas involved...If one constructs a list of topics central to a history course, then they would closely resemble those chosen here."(David Parrott, Australian Mathematical Society)This book offers a collection of historical essays detailing a large variety of mathematical disciplines and issues; it’s accessible to a broad audience. This third edition includes new chapters on simple groups and new sections on alternating groups and the Poincare conjecture. Many more exercises have been added as well as commentary that helps place the exercises in context.

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Plant biotechnology applies to three major areas of plants and their uses: (1) control of plant growth and development; (2) protection of plants against biotic and abiotic stresses; and (3) expansion of ways by which specialty foods, biochemicals, and pharmaceuticals are produced. The topic of recent advances in plant biotechnology is ripe for consideration because of the rapid developments in this ?eld that have revolutionized our concepts of sustainable food production, cost-effective alt- native energy strategies, environmental bioremediation, and production of pla- derived medicines through plant cell biotechnology. Many of the more traditional approaches to plant biotechnology are woefully out of date and even obsolete. Fresh approaches are therefore required. To this end, we have brought together a group of contributors who address the most recent advances in plant biotechnology and what they mean for human progress, and hopefully, a more sustainable future. Achievements today in plant biotechnology have already surpassed all previous expectations. These are based on promising accomplishments in the last several decades and the fact that plant biotechnology has emerged as an exciting area of research by creating unprecedented opportunities for the manipulation of biological systems. In connection with its recent advances, plant biotechnology now allows for the transfer of a greater variety of genetic information in a more precise, controlled manner. The potential for improving plant productivity and its proper use in agric- ture relies largely on newly developed DNA biotechnology and molecular markers.

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Stratospheric processes play a signi?cant role in regulating the weather and c- mate of the Earth system. Solar radiation, which is the primary source of energy for the tropospheric weather systems, is absorbed by ozone when it passes through the stratosphere, thereby modulating the solar-forcing energy reaching into the t- posphere. The concentrations of the radiatively sensitive greenhouse gases present in the lower atmosphere, such as water vapor, carbon dioxide, and ozone, control the radiation balance of the atmosphere by the two-way interaction between the stratosphere and troposphere. The stratosphere is the transition region which interacts with the weather s- tems in the lower atmosphere and the richly ionized upper atmosphere. Therefore, this part of the atmosphere provides a long list of challenging scienti?c problems of basic nature involving its thermal structure, energetics, composition, dynamics, chemistry, and modeling. The lower stratosphere is very much linked dynamically, radiatively,and chemically with the upper troposphere,even though the temperature characteristics of these regions are different. The stratosphere is a region of high stability, rich in ozone and poor in water - por and temperature increases with altitude. The lower stratospheric ozone absorbs the harmful ultraviolet (UV) radiation from the sun and protects life on the Earth. On the other hand, the troposphere has high concentrations of water vapor, is low in ozone, and temperature decreases with altitude. The convective activity is more in the troposphere than in the stratosphere.

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This volume is the fifth volume of A Corpus of Rembrandt Paintings, a project devoted to all Rembrandt’s paintings. This is the work of ‘The Rembrandt Research Project’, consisting of a group of scholars led since 1993 by Professor Ernst van de Wetering. The project began in 1968 with the aim of separating Rembrandt’s own paintings from the vast number of Rembrandtesque paintings made by his many apprentices and followers. Having opted for a chronological approach to the cataloguing of Rembrandt’s paintings (from 1625 till 1642) in the first three volumes, it was decided in 1993 to adopt a thematic approach for further volumes. This was largely to facilitate the recognition of different hands. The new approach yielded much more information not only about Rembrandt’s working methods but also about the function and meaning of his works. This expanded field of view meant that etchings and drawings with similar themes also needed to be included. In 2005 Volume IV appeared, devoted to Rembrandt’s self-portraits, in painting, etching and drawing. Volume V consists of a catalogue and analysis of the so-called small-scale history and genre paintings. That theme was chosen because this type of complex work shows a variety of full-length protagonists acting in different narrative settings. For this reason, in the 17th century, painting, etching or drawing biblical and mythological scenes was looked upon as an artist’s greatest challenge. The choice of this theme proved to be highly fruitful in several ways. Small-scale history pieces reveal Rembrandt’s artistic ambitions most clearly. They also offer the authors a much more accurate view of the daily routine in Rembrandt’s studio; his apprentices mostly copied this type of work or used it as a starting point for their own. As a result it was easier to distinguish the works by the master himself from those of his pupils. All aspects of the skills necessary to create a pictorial illusion play a part in the creation of small-figured history paintings. These aspects were referred to as ‘the basis of the noble art of painting’ in Rembrandt’s days. Two seventeenth century painter/theoreticians discussed these principles systematically in two books which up till now have only sporadically been consulted in the context of 17th century studio practice. Karel van Mander wrote his Grond der edel vry schilder-const [Basis of the Art of Painting] in 1604 and Samuel van Hoogstraten produced his Inleyding tot de hooge schoole der schilderkonst [Academy of Painting] in 1678. Van Hoogstraten was a pupil of Rembrandt between 1642 and ’48. Comparing the two books and considering them in relation to Rembrandt’s oeuvre, gradually reveals his original views on painting and how these had developed during his career. Thus, the authors of this new Volume of A Corpus have gained an unexpected and profound insight into Rembrandt’s ideas and approach to his art. The ‘basic aspects’ of painting included the following topics: function and methods of drawing; human proportions; various positions, poses and gestures of figures; ways of arranging a scene’s protagonists in a composition; facial expressions of a variety of emotions; light, shadows and reflected light; landscape and animals; draperies and articles of clothing; methods of painting, and various characteristics and uses of colours. The way these ‘basic aspects’ were selected and dealt with presumed that the more practical side to the art of painting would be learned by the apprentice in the daily routine of his master’s studio. With the development of art history in the nineteenth century the ‘basic aspects’ of the art of painting listed above acquired the vague label of ‘style’. However, the seventeenth century categorization of the ‘basic aspects’ provides a much more acute means of probing the views and criteria for judging a painting by Rembrandt and his contemporaries than the concept of ‘style’. Volume V in the series A Corpus of Rembrandt Paintings breaks new ground from the point of view of art history, not only in its approach to Rembrandt as an artist, but more particularly to his thinking about painting. Moreover, a detailed comparison of Rembrandt’s works and those by his apprentices who based their works on his, led to a profound and detailed understanding of Rembrandt’s views on pictorial quality. In art historical literature quality usually does not feature prominently since it is regarded as being too subjective. This comparative approach, together with the analysis of seventeenth century categories of thought about painting, have given the research on Rembrandt a new impetus, at the same time allowing us to see more clearly through seventeenth century eyes. That is why the new volume of the ‘Corpus’ is an important publication – not only for art historians but also for all who want to fully enjoy the numerous works of art that date back to the Dutch Golden Age, now scattered in museums around the world.

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This book is an important account of the state of the art of both theoretical and practical issues in the present-day research on conceptual change. Unique in its complete treatment of the questions that should be considered to further current understanding of knowledge construction and change, this book is useful for psychologists, cognitive scientists, educational researchers, curriculum developers, teachers and educators at all levels and in all disciplines.

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This volume provides detailed protocols for the isolation, enumeration, characterization of diverse bacteriophages, including both small and jumbo bacteriophages, from soil, fecal, municipal wastewater, and from food niche samples. Chapters highlight the diversity of bacteriophages in different environments, quantifications using culture and molecular techniques, protocols for isolation, interaction of bacteriophage proteins with host cells, and how to use bacteriophages to transfer foreign genetic elements to bacterial strains. In addition to the above, chapters feature the application of bacteriophages/bacteriophage-derived products. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips (in the Notes section) on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacteriophages: Methods and Protocols aims to ensure successful results in further study of this vital field.

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This detailed volume explores the development of technologies and protocols that are currently being used to understand the nature and activities of the plant cytoskeleton. A focus for many of the chapters is on sample preparation, as the quality of plant organ/tissue preparation, from single to multicellular samples, determines the quality of the data. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, The Plant Cytoskeleton: Methods and Protocols serves as an ideal guide for researchers interested in or starting to be interested in plant cell and molecular biology research.

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This volume looks at a collection of the latest techniques used to quantify the genome-by-environment-by-management (GxExM) interactions in a variety of model and plant crops. The chapters in this book are organized into five parts. Part One discusses high-throughput plant phenotyping (HTPP) protocols for plants growing under controlled conditions. Part Two present novel algorithms for extracting data from seed images, color analysis from fruits, and other digital readouts from 2D objects. Part Three covers molecular imaging protocols using PET and X-ray approaches, and Part Four presents a collection of HTPP techniques for crops growing under field conditions. The last part focuses on molecular analysis, metabolomics, network analysis, and statistical methods for the quantitative genetic analysis of HTP data. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, High-Throughput Plant Phenotyping: Review and Protocols is a valuable resource for both novice and expert researchers looking to learn more about this important field.Chapter 21 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

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This volume details methods on several aspects of circadian research. Chapters guide readers through the latest techniques and a wide variety of daily rhythmic processes, model organisms, circadian rhythms in the SCN and in peripheral organs, and describing in vitro systems and in silico methods. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Circadian Regulation: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field. Chapters 3, 4, 8, and 17 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

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This collection explores the latest advances in riboregulators, such as RNA-only systems and ribonucleoprotein systems, and provides detailed techniques to study, evolve, and design them. Beginning with a set of chapters focused on the design and application of small RNA (sRNA) regulator systems, the book continues with sections on techniques to create switchable riboregulator systems known as riboswitches, technologies that leverage RNA-guided CRISPR-Cas systems to edit the epigenome, control gene expression, and create diagnostics, as well as computational and experimental techniques to investigate the sequence-structure-function relationship of RNA systems that can both advance fundamental understanding and rational design of riboregulators. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Riboregulator Design and Analysis is an ideal guide for scientists and engineers interested in the design and application of riboregulators and driving further innovation in the field.

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The Bulletin of Mathematical Biology, the official journal of the Society for Mathematical Biology, disseminates original research findings and other information relevant to the interface of biology and the mathematical sciences. Contributions should have relevance to both fields. In order to accommodate the broad scope of new developments, the journal accepts a variety of contributions, including: Original research articles focused on new biological insights gained with the help of tools from the mathematical sciences or new mathematical tools and methods with demonstrated applicability to biological investigations Research in mathematical biology education Reviews Commentaries Perspectives, and contributions that discuss issues important to the profession All contributions are peer-reviewed.

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This detailed volume provides an overview of recent advances in the application of genomic technologies in several domains of marine biology, raising awareness of various DNA- and RNA-based technologies. Genomic methods are essential in identifying previously undetected taxonomic (e.g. DNA barcoding), genetic (e.g. sequencing), and functional (e.g. gene expression, analysis of metabolites) diversity, as shown in the chapters of this book, with sections focusing on next generation sequencing (NGS) technologies, bioinformatics in marine genomics research, marine biotechnology, as well as a variety of methods successfully applied in fish. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Marine Genomics: Methods and Protocols highlights the utility of numerous lab protocols and their potential to provide deeper insight into physiological and ecological mechanisms in marine life.

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This second edition volume expands on the previous edition by exploring the latest advancements in high throughput screening (HTS) in toxicity studies by using in vitro, ex vivo, and in vivo models. This volume also covers the application of artificial intelligence (AI) and data science to curate, manage, and use HTS data. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, High Throughput Screening Assays in Modern Toxicology, Second Edition is a valuable resource for scientists pursuing chemical toxicology research. This book will aid scientists and researchers in translating new HTS techniques into standardized chemical toxicology assessment tools that can refine, reduce, and replace animal testing.

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This volume explores the latest technological advances and covers all facets of systems medicine with respect to precision medicine. The chapters in this book are organized into four parts. Part One highlights the recent achievements in proteomics for biomarkers identification, integration of omics and phenotypic data for precision medicine, and medicine-guided treatment of drug-induced Stevens-Johnson syndrome. Part Two covers systems-based computational approaches for pharmaceutical research and drug development, the principle of optimizing systemic exposure of drugs, and Animal Rule for drug repurposing. Part Three looks at computational tools and methodologies of network biology, quantitative systems toxicology, and modeling and stimulating patient response variabilities. Part Four talks about how systems medicine can address unmet medical and health needs, and identify educational needs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Systems Medicine: Methods and Protocols is a valuable resource for the scientific community that will help researchers work together toward the further advancement of achieving the goal of promoting global health.Chapter 8 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com

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This volume discusses the latest techniques used by researchers to measure cAMP activity at the cell population, whole cell, and subcellular level. The techniques covered in the book address questions related to cAMP compartmentalization, which look at relevant protein-protein interactions that increase the spatial and temporal resolution of cAMP signals detection, and that can help in the integration of the increasingly complex information that is becoming available in this field. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, cAMP Signaling: Methods and Protocols, Second Edition is a valuable resource for scientists and researchers who are interested in learning more about this important and developing field. Chapter 7 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

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This second edition provides detailed practical information on important methods employed in the engineering of plant secondary metabolism pathways. New and updated chapters guide readers through extraction, quantification, purification, localization, characterization, data mining and processing, biosynthesis modulation, and pathway engineering of representative classes of plant specialized metabolites. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, list of necessary materials and reagents, tips on troubleshooting and known pitfalls, and step-by-step descriptions of readily reproducible protocols. Authoritative and cutting-edge, Plant Secondary Metabolism Engineering: Methods and Protocols, Second Edition aims to be a useful practical guide to help researchers working in this exciting field.

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This volume details methods and protocols covering multiple aspects of Medulloblastoma. Divided into four parts, chapters guide readers through nucleic acids detection and analysis, cell-based analysis methodologies, and applications of patient-information on designing better experimental strategies for future drug development efforts in Medulloblastoma. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Medulloblastoma: Methods and Protocols aims to deliver a clear-cut and standardized set of protocols to a broad scientific community.

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This detailed book explores new molecular biological techniques for the detection of both antigens and antibodies of porcine diseases. Assays examined within this collection include improved methods of nucleic acid extraction, polymerase chain reaction (PCR), droplet digital PCR (ddPCR), polymerase spiral reaction (PSR), cross-priming amplification (CPA), enzyme-linked immunosorbent assay (ELISA), as well as peptide nucleic acid (PNA) based tools, aptamer-based tools, and lateral flow assays and different immune assay-based diagnostics for porcine diseases. As part of the Springer Protocols Handbooks series, the present book contains the type of in-depth knowledge on important diagnostics tools that provide a vital source of information for scientists, researchers, and students from different fields. Authoritative and practical, Protocols for the Diagnosis of Pig Viral Diseases aims to guide researchers toward developing new technologies for the diagnosis of pig pathogens.

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This volume provides detailed methods and key approaches used to mechanistically study DNA damage, as well as the factors involved in the damage response. Chapters guide readers through proteomics and biophysical approaches, analyzing protein function, quantifying DNA replication dynamics and nucleic acid base damage, as well as biochemical reconstitution of key pathways involved in DNA repair. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, DNA Damage Responses: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.

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This volume offers a comprehensive collection of experimental approaches to study Solanum tuberosum (potato). Chapters are divided into five sections covering a general overview of potato, the research fields of molecular biology, omics approaches, and bioinformatics, and finally, the application of the generated knowledge for crop improvement. Written in the format of the highly successful Methods in Molecular Biology series, each wet-lab chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Solanum tuberosum: Methods and Protocols aims to provide a collection of methods for the potato research community that will enable scientists gain insight into the world of the potato.Chapter 2 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

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This detailed book explores examples of current in vitro and in silico techniques that are at the forefront of lipid membrane research today. Beginning with methods and strategies associated with the creation and use of lipid membrane models in various research settings, the volume continues with electrical impedance spectroscopy strategies and methods to identify how ions and proteins interact with model lipid bilayers, guidance on lipid bilayer in silico molecular dynamics modeling, novel techniques to explore lipid bilayer characteristics using neutron scattering, IR spectroscopy, and atomic force microscopy (AFM), as well as unique fluorescence techniques. Written in the highly successful Methods in Molecular Biology series style, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Membrane Lipids: Methods and Protocols serves as an ideal guide for researchers seeking to further investigate the often complicated world of lipid membrane biophysics.

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This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume II guides readers through chapters on mitochondrial dysfunction, functional’ mitochondria, mitochondrial retrograde, mitochondrial dNTP pool quantification, mitochondrial ADP-ribosylation, blue-native gel approach, 3D optical cryo-imaging method, mitochondrial ATP and ROS production, protocol for untargeted metabolomic analysis, and methods for analysis of nitrotyrosine-containing proteins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 2: Assessing Mitochondria aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.

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This volume provides readers with essential protocols for dissecting the host-fungus interaction, and engages researchers in study of mammalian disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Host-Fungal Interactions: Methods and Protocols aims to ensure successful results in the further study of this vital field.

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This book addresses the major periodontal pathogens implicated as causal agents in periodontal disease, including Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans, and Prevotella spp. Beginning with methods for bacterial genetic manipulation, the volume continues with sections on experimental methods to examine virulence factors, interactions with other pathogenic microorganism and host cells, as well as a chapter on an animal model of periodontitis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Periodontal Pathogens: Methods and Protocols serves as an extensive and useful reference for researchers studying periodontal pathogens and will help elucidate the causes of periodontal disease and the systemic diseases related to it.

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This volume explores the latest methods used by researchers to study the detection, characterization, and various aspects of viroids. The chapters in this book are organized into seven parts and cover topics such as detection methods based on the biology of viroids; detection techniques based on electrophoresis and hybridization techniques; PCR-based techniques that provide high degrees of sensitivity; emerging area of nucleic acid sequence-based technology; and emerging techniques in viroid research such as RNA silencing, splicing, and viroid structure. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Viroids: Methods and Protocols is a valuable resource for researchers and graduate students who are working with viroid diseases.

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This book is an introductory text in functional analysis. Unlike many modern treatments, it begins with the particular and works its way to the more general. From the reviews: "This book is an excellent text for a first graduate course in functional analysis....Many interesting and important applications are included....It includes an abundance of exercises, and is written in the engaging and lucid style which we have come to expect from the author." --MATHEMATICAL REVIEWS

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Designed for students preparing to engage in their first struggles to understand and write proofs and to read mathematics independently, this is well suited as a supplementary text in courses on introductory real analysis, advanced calculus, abstract algebra, or topology. The book teaches in detail how to construct examples and non-examples to help understand a new theorem or definition; it shows how to discover the outline of a proof in the form of the theorem and how logical structures determine the forms that proofs may take. Throughout, the text asks the reader to pause and work on an example or a problem before continuing, and encourages the student to engage the topic at hand and to learn from failed attempts at solving problems. The book may also be used as the main text for a "transitions" course bridging the gap between calculus and higher mathematics. The whole concludes with a set of "Laboratories" in which students can practice the skills learned in the earlier chapters on set theory and function theory.

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A concise treatment of topics from group theory and representation theory for use in a one-term course. Focussing on the non-commutative side of the field, this advanced textbook emphasizes the general linear group as the most important group and example.Readers are expected to be familiar with groups, rings, and fields, and to have a solid knowledge of linear algebra. Close to 200 exercises of varying difficulty serve both to reinforce the main concept of the text and to introduce the reader to additional topics.

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Functional Equations and Inequalities with Applications presents a comprehensive, nearly encyclopedic, study of the classical topic of functional equations. This self-contained monograph explores all aspects of functional equations and their applications to related topics, such as differential equations, integral equations, the Laplace transformation, the calculus of finite differences, and many other basic tools in analysis. Each chapter examines a particular family of equations and gives an in-depth study of its applications as well as examples and exercises to support the material.

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This self-contained text provides a solid introduction to global and nonlinear optimization, providing students of mathematics and interdisciplinary sciences with a strong foundation in applied optimization techniques. The book offers a unique hands-on and critical approach to applied optimization which includes the presentation of numerous algorithms, examples, and illustrations, designed to improve the reader’s intuition and develop the analytical skills needed to identify optimization problems, classify the structure of a model, and determine whether a solution fulfills optimality conditions.

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These notes were first used in an introductory course team taught by the authors at Appalachian State University to advanced undergraduates and beginning graduates. The text was written with four pedagogical goals in mind: offer a variety of topics in one course, get to the main themes and tools as efficiently as possible, show the relationships between the different topics, and include recent results to convince students that mathematics is a living discipline.

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In recent years, the fixed point theory of Lipschitzian-type mappings has rapidly grown into an important field of study in both pure and applied mathematics. It has become one of the most essential tools in nonlinear functional analysis. This self-contained book provides the first systematic presentation of Lipschitzian-type mappings in metric and Banach spaces. The first chapter covers some basic properties of metric and Banach spaces. Geometric considerations of underlying spaces play a prominent role in developing and understanding the theory. The next two chapters provide background in terms of convexity, smoothness and geometric coefficients of Banach spaces including duality mappings and metric projection mappings. This is followed by results on existence of fixed points, approximation of fixed points by iterative methods and strong convergence theorems. The final chapter explores several applicable problems arising in related fields. This book can be used as a textbook and as a reference for graduate students, researchers and applied mathematicians working in nonlinear functional analysis, operator theory, approximations by iteration theory, convexity and related geometric topics, and best approximation theory.

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