Search results for ""Royal Society of Chemistry""

Disposable electrodes have been widely used as a sensing platform in electrical and electrochemical sensors owing to the possibility of quantitative detection using clinical biomarkers with high precision, sensitivity and reproducibility, which are necessary for accurate diagnosis of the health condition of an individual. This book focusses on the emerging disposable electrochemical sensors in the health sector and the advancement of analytical devices to monitor diabetic, cancer and cardiovascular patients using different nanomaterials. It discusses the upcoming strategies, advantages and the limitations of the existing devices using disposable electrodes. Uniquely, it covers in-depth knowledge of mechanistic features of various designs of screen-printing electrodes and the material aspects required of sensors developed for the healthcare field. It also looks at the portable devices using a variety of materials and the future directions for research in this area. Appealing to the health care industry, this book is aimed at academic and research institutes at both the graduate and postgraduate level. The contributors are leading experts in the field and they are providing guidance for the next decade of research in the field of disposable electrochemical biosensors.

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Since the discovery of graphene, two-dimensional nanomaterials including Transition metal dichalcogenides (TMDCs), Hexagonal Boron Nitride (hBN), non-layered compounds, black phosphorous, and Xenes with large lateral dimensions, have emerged as promising candidates for heterogenous electrocatalysis owing to their exceptional physical, chemical, and electronic properties. The tremendous opportunities of using 2D nanomaterials in electrochemical CO2 reduction arises from their unique properties and vast number of applications. Covering the fundamentals, properties, and applications, all aspects of 2D nanomaterial composites within carbon dioxide conversion are discussed. The industrial scale-up and new challenges that exist in the field of electrochemical reduction of carbon dioxide will also be presented. With chapters written by internationally recognized researchers, this state-of-the-art overview will serve the growing interest amongst academic and industrial researchers in understanding 2D nanomaterials composites, their hidden interfaces and nanoscale dispersion of the metal oxide with nanocomposites for specific uses in carbon dioxide conversion to chemicals for fuel applications. This book will be of interest to graduate students and researchers in materials science, energy, and environmental science, as well as those in industry.

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This first volume chronicles the early stages of the outbreak and world-wide spread of SARS-Cov-2 (COVID-19) and delineates the role of several disciplines in therapeutic and control measures. Documenting the epidemiologic response from China, the clinical evaluation, pathology and intial therapeutics that were available during the first 6 months and onwards of the outbreak, this book records how the response to the pandemic was mounted and how various branches of science and research combined to rapidly expand our understanding of the disease.

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Molecular chaperones are critical to control protein quality in all living cells. Understanding chaperone function at the atomic level, and in particular its mode of interaction with client proteins, is crucial to understanding the fundamental roles chaperones play in biology. This book fills a gap in the literature by comprehensively summarizing and discussing new advanced experimental techniques for their analysis. Providing a comprehensive overview of advanced biophysical methods for the characterization of molecular mechanisms of molecular chaperones, the majority of the contributions are NMR methodology. This is the method of choice for atomic resolution studies of such systems. Additional notable biophysical approaches are considered to present all relevant current developments in exploring chaperone function and the transient and dynamic interactions with their client proteins. The book is targeted at both current practitioners of structural biology and biophysical chemistry and scientists who are interested in entering the field. It could be useful for graduate students as supplementary reading.

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Smart materials stimulated by chemical or by logical signals hold promise for many applications, including new sensors and actuators for medicine, environmental and process control. In contrast to other books on responsive materials which are restricted to sensing, this volume not only highlights fundamental chemical and physical principles but also focuses on the use of smart materials for applications such as drug delivery, wound healing, cell adhesion, tuneable vesicles, surface control, smart paints and glasses, separations, oil recovery and artificial muscles. In this completely updated and expanded edition, readers are introduced to the area with chapters reflecting the enormous expansion of the field in recent years. Different responsive material systems will be covered including hydrogels, membranes, thin layers, polymer brushes, chemomechanical and imprinted polymers, nanomaterials and silica particles. With contributions from internationally recognised experts, the book will appeal to graduate students and researchers in academia, healthcare and industry interested in functional materials and their applications.

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Bisphenol A (BPA) is a high production volume endocrine-disrupting chemical present in numerous consumer products. Extensive use of BPA has led to wide-spread contamination in the air, soil, and water, leading to ubiquitous human exposure. Research into BPA has grown exponentially over the past ten years, with numerous modes of action being identified that impact human health and disease development. While BPA has estrogenic effects, emerging literature has identified several non-receptor mediated modes of action, such as epigenetic reprogramming, that can affect the long-term health of the population. This book highlights the multiple modes of action BPA can use to reprogram cells genetically and metabolically. By compiling critical studies in BPA and outlining the connections and disparities in the literature to build a broader understanding of this complex endocrine-disrupting chemical and its impact on the environment and human health, this book is an ideal resource for postgraduates and researchers in a range of disciplines from toxicology to epigenetics and cancer epidemiology.

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The physical properties associated with the saturated and trans fats obtained through partial hydrogenation of vegetable oils (PHVOs) provide the solid fat content, melting and textural properties that consumers require in food products like butter, margarines, vegetable creams, spreads, and confectionary fats. However, saturated and trans fats increase low density lipoprotein, while trans fats also lower high-density lipoprotein serum levels. These indicators increase the risk of developing cardiovascular disease, type II diabetes, stroke, and have recently been associated with metabolic syndrome. Consequently, regulatory agencies worldwide have passed legislation restricting the addition of PHVOs and their derivatives (i.e., shortenings) to food products. This has lead research groups worldwide to investigate different mechanisms to provide structural and physical properties to edible, healthy unsaturated oils. The overall objective is to achieve similar functional properties to those provided by PHVOs and shortenings to food products. This book encompasses the work of leading researchers discussing, from a scientific and technological perspective, the latest and most innovative approaches to structure edible oils without the use of trans fats. Additionally, the authors discuss practical uses and technical limitations associated with the use of "structured edible oils" in different food systems. Appealing to researchers and professionals working in lipid science, food chemistry and fat metabolism, it fills the gap in the literature for a book in this fast-changing field.

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Magnetically responsive soft matter is a colloidal model system where interparticle interactions can be tuned through external magnetic fields. Covering the most recent literature in the field, with special emphasis on the physical mechanisms behind their rheological behaviour, this book aims to demonstrate the controllability of soft matter through an external (magnetic) stimulus. With chapters written by leading experts, fundamental topics are complemented by cutting edge research, in particular, discussions on advances in sedimentation stability, structural characterization using microCT, surface functionalization, bidisperse composites, self-assembly at interfaces and collective dynamics, friction and shear-thickening, dynamics, self-assembly and rheology under unsteady triaxial magnetic fields, theoretical developments and particle level numerical simulations, including contact forces and biomedical and tissue engineering applications. This complete perspective of the field attempts to bridge the gap between fundamentals and applications and is an excellent addition to any soft matter scientist’s library.

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Green toxicology is an integral part of green chemistry. One of the key goals of green chemistry is to design less toxic chemicals. Therefore, an understanding of toxicology and hazard assessment is important for any chemist working in green chemistry, but toxicology is rarely part of most chemists' education. As a consequence, chemists lack the toxicological lens necessary to view chemicals in order to design safer substitutions. This book seeks to fill that gap and demonstrate how a basic understanding of toxicology, as well as the tools of in silico and in vitro toxicology, can be an integral part of green chemistry. R&D chemists, product stewards, and toxicologists who work in the field of sustainability, can all benefit from integrating green toxicology principles into their work. Topics include in silico tools for hazard assessment, toxicity testing, and lifecycle considerations, this book aims to act as a bridge between green toxicologists and green chemists.

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Problem solving is central to the teaching and learning of chemistry at secondary, tertiary and post-tertiary levels of education, opening to students and professional chemists alike a whole new world for analysing data, looking for patterns and making deductions. As an important higher-order thinking skill, problem solving also constitutes a major research field in science education. Relevant education research is an ongoing process, with recent developments occurring not only in the area of quantitative/computational problems, but also in qualitative problem solving. The following situations are considered, some general, others with a focus on specific areas of chemistry: quantitative problems, qualitative reasoning, metacognition and resource activation, deconstructing the problem-solving process, an overview of the working memory hypothesis, reasoning with the electron-pushing formalism, scaffolding organic synthesis skills, spectroscopy for structural characterization in organic chemistry, enzyme kinetics, problem solving in the academic chemistry laboratory, chemistry problem-solving in context, team-based/active learning, technology for molecular representations, IR spectra simulation, and computational quantum chemistry tools. The book concludes with methodological and epistemological issues in problem solving research and other perspectives in problem solving in chemistry. With a foreword by George Bodner.

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Chronobiology and Chronomedicine is an ideal introduction for postgraduates in various fields, reviewing developments and outlining methods to show the depth and breadth of chronobiology, as well as an invaluable companion to researchers with an interest in developing novel therapeutic approaches.

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With the expansion of human settlements and the environmental changes brought about by human activity and pollutants, toxicology and risk assessment of amphibian species has become increasingly of interest to toxicologists involved in environmental research. This book focuses specifically on environmental risk assessment in premetamorphic stages and adults of amphibians. Amphibian ecotoxicology is not totally understood in scientific research and as such environmental risk assessment in these vertebrates is an area of rapidly growing interest. It has the potential to answer some of the questions regarding risks to our environment. An ideal companion, this book will be useful to toxicologists and ecologists investigating risk assessment in the environments of amphibians, while also of interest to those working in conservation biology, biological invasion, biocontrol and habitat management.

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The phytochemical constituents of plants fall into two main categories based on their role in basic metabolic processes: primary and secondary. Primary metabolites are involved in basic life functions and are similar in all living cells, whereas secondary metabolites are derived from subsidiary pathways. Although traditionally referred to as secondary metabolites, more recently these compounds have been termed ‘plant specialized metabolites’, as the exact biochemical boundary between primary and secondary metabolites has not been fully established. Plant specialized metabolites are the main elements in the study and use of ‘medicinal’ plants and herbs, as well as in nutrition and food chemistry. In modern medicine, plant specialized metabolites provide many of the lead compounds in the production of medicines targeted at treating a broad variety of diseases. Such metabolites also play an important role in sessile plants to resist and withstand different biotic and abiotic stresses. Plant specialized metabolites are classified according to their chemical structures and this book will present the different classes in turn, while discussing their sources and distribution in plant families, their biosynthetic pathways, and their important and notable uses in phytochemistry and pharmacology. Chemical Diversity of Plant Specialized Metabolites will be a useful guide and reference point for chemists and students in many disciplines including synthetic organic chemists, medicinal chemists, plant scientists, pharmacognosists, chemical ecologists, bioengineers, and synthetic biologists, in addition to those working in related fields.

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Cellulose nanoparticles (CNP) are a class of bio-based nanoscale materials, which are of interest due to their unique structural features and properties such as biocompatibility, biodegradability, and renewability. They are promising candidates for applications including in biomedicine, pharmaceuticals, electronics, barrier films, nanocomposites, membranes, and supercapacitors. New resources, extraction procedures and treatments are currently under development to satisfy increasing demands for cost-effective and sustainable methods of manufacturing new types of cellulose nanoparticle-based materials on an industrial scale. Cellulose Nanoparticles: Chemistry and Fundamentals covers the synthesis, characterization and processing of cellulose nanomaterials. It aims to address the recent progress in the production methodologies for cellulose nanoparticles, covering principal cellulose resources and the main processes used for isolation. Chapters cover the preparation and characterisation of cellulose nanocrystals and nanofibrils. Together with Volume 2, these books form a useful reference work for graduate students and researchers in chemistry, materials science, nanoscience and green nanotechnology.

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Coffee rings, paint drying, blood splatter are all examples of complex fluids drying. Understanding the phenomena of complex fluid drops with respect to drying is important for technology and a lot of research in academia and industry is poured into this topic. This book addresses this industrially important area and provides a thorough grounding to the field. Addressing the fundamental underpinnings of wetting, spreading and drying, the book then takes the reader through key applications grouped into themes, including colloidal droplets (used in printing) and biological (e.g. bloodstain analysis for forensics). With a section on modelling and simulation to balance experiment with computational tools, this book will appeal to anyone working in complex fluids across classical fluid mechanics, soft matter, and chemical, biological and mechanical engineering

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Droplet microfluidics offers tremendous potential as an enabling technology for high-throughput screening. It promises to yield novel techniques for personalised medicine, drug discovery, disease diagnosis, establishing chemical libraries, and the discovery of new materials. Despite the enormous potential to contribute to a broad range of applications, the expected adoption has not yet been seen, partly due to the interdisciplinary nature and the fact that, up until now, information has been scattered across the literature. This book goes a long way to addressing these issues. Edited by two leaders, this book has drawn together expertise from around the globe to form a unified, cohesive resource for the droplet microfluidics community. Starting with the basic theory of droplet microfluidics before introducing its use as a tool, the reader will be treated to chapters on important techniques, including robust passive and active droplet manipulations and applications such as single cell analysis, which is key for drug discovery. This book is a go-to resource for the community yearning to adopt and promote droplet microfluidics into different applications and will interest researchers and practitioners working across chemistry, biology, physics, materials science, micro- and nano-technology, and engineering.

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Thermoelectric devices convert a heat flux directly into electrical power. They afford opportunities to achieve efficiency savings in a variety of applications, through the conversion of otherwise waste heat into useful electrical energy. Operated in reverse mode, they provide effective thermal management in areas ranging from cooling of electronic components to battery conditioning in electric vehicles. Implementation of thermoelectric technology requires materials with improved performance and stability, containing readily-available and inexpensive elements. A range of thermoelectric materials for use in different temperature regimes has emerged. Knowledge of the complex relationship between composition, structure and physical properties is central to understanding the performance of these advanced materials. This book provides both an introduction to the field of thermoelectrics and a survey of the state-of-the-art. Chapters review the important new families of advanced materials that have emerged and taken the field beyond traditional thermoelectric materials such as Bi2Te3, PbTe and SiGe. The emphasis is on the relationship between chemical composition, structure over a range of length scales and the physical properties that underlie performance. Edited by a leader in the field, and with contributions from global experts, Inorganic Thermoelectric Materials serves as an introduction to thermoelectric materials and is accessible to advanced undergraduates and postgraduates, as well as experienced researchers

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Biomaterials offer the potential to restore and supplement the function of tissues and organs following injury or disease. The use of inorganic materials in the clinic to date has been widespread, in the form of metallic joint replacements and ceramic dental and bone implants. Exciting new medical applications continue to emerge, enabled by innovative materials for neural interfaces and as anti-fouling agents. The Chemistry of Inorganic Biomaterials overviews the underlying chemistry behind the most common and cutting-edge inorganic materials in current use, or approaching use, in vivo. Framed from the context of the overarching material class/application, it provides a balanced and critical overview of the field by bringing together experts in both the fundamental inorganic and material chemistry, as well as key clinical considerations for biomedical applications. Written in an accessible style, this book will be of interest to advanced undergraduates, postgraduates and researchers in biomaterials, inorganic materials and materials chemistry.

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Bringing together expert researchers in the fields of microbiome, metabolism, and nutrition research, this book compiles the current state of knowledge from authorities specifically on how diet regulates microbial function with metabolic implications for the human host. Chapters cover the broad concepts of microbial-host interactions under the dietary influences of specific macronutrients, micronutrients, small molecule generation and bile acid circulation, with inclusion of later clinical chapters encompassing topics like bariatric surgery and our current understanding of probiotics, prebiotics, and synbiotics. Covering a timely topic from a functional standpoint, the book fills a gap in the existing literature. While increased attention is placed on descriptive work, it will importantly highlight emerging functional and mechanistic research findings that illustrate the inner workings of the dietary-microbial-host orchestration of metabolic regulation. Providing an exciting summary of the importance of current microbial function, it will also summarize the next major directions in the field of microbiome research.

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Hydrogenation is a key reaction in both the food and petrochemical industries, where it is used to reduce carbon–carbon double bonds. Without a catalyst, hydrogenation reactions require extreme temperatures to occur, meaning catalysts are essential for the reaction to be industrially useful. During the past decade, the properties of many carbon nanomaterials that are relevant to hydrogenation catalysis have been described, including carbon nanotubes (CNTs), carbon nanofibers (CNFs), carbon nanohorns (CNHs), graphene oxide (GO), reduced graphene oxides (rGO) and fullerenes, that are relevant to hydrogenation catalysis, have been described. For many of these the production methods have advanced to the commercial stage. Numerous studies on the development of catalysts on carbon nano-supports have appeared in the scientific literature and these catalysts have shown remarkable activity and specificity. Carbon Nanomaterials in Hydrogenation Catalysis is a valuable reference for researchers and chemical engineers working on improving hydrogenation processes and those interested in applications for carbon nanomaterials. Covering their production, modification and applications as a catalyst support this book provides an in-depth review of the current state-of-the art in using carbon nanomaterials for hydrogenation reactions.

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Thermal energy storage refers to a collection of technologies that store energy in the forms of heat, cold or their combination, which currently accounts for more than half of global non-pumped hydro installations. The potential market for thermal energy storage on future low-carbon energy systems and associated social and economic impacts are enormous, with significant progress having been made in recent years. Following an introduction to thermal energy and thermal energy storage, the book is organised into four parts comprising the fundamentals, materials, devices, energy storage systems and applications of thermal energy storage. Chapters cover topics including materials properties, formulation and manufacture, as well as modelling at the material and device scale. Edited by a leader in the field, and with contributions from internationally renowned authors, this title will appeal to graduate students and researchers in energy, energy storage, materials engineering, chemical and process engineering, mechanical engineering and manufacture technologies.

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This is the first book for some years that provides a comprehensive overview of food oral processing. It includes fundamental chapters at the beginning of each section to aid the understanding of the later more specific oral processing chapters. The field is rapidly developing, and the systems researched in the context of food oral processing become increasingly complex and therefore the fundamental sections include information on how to build complex food systems. The main coverage includes the biomechanics of swallowing, the biophysics of mouthfeel and texture as well as the biochemistry of flavours and how food microstructures can be manipulated. It contains up-to-date research findings, looking at consumer preferences and the response to these preferences by food process technologists and those developing new foods. The book will be of interest to postgraduate students and researchers in academia and industry who may be from very diverse backgrounds ranging from food process engineers to functional food developers and professionals concerned with swallowing and taste disorders.

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Globally we are being confronted by the depletion of many natural resources as a result of unsustainable use and increasing global population. Although the debate on the bioeconomy has gained momentum in recent decades, the interest in certifications and standards for biobased products is still weak. This book aims to fill this gap by promoting a holistic approach, which covers environmental, social and economic sustainability aspects and pushes forward the development of a circular, biobased economy. This book promotes the development of sustainability schemes (including standards, labels and certifications) for the assessment of biobased products, which are fundamental to the establishment of a cutting-edge sustainable bioeconomy. Chemical-related, globally relevant case studies are used throughout the book. The content covers a range of issues from upstream and downstream environmental, techno-economic and social assessment, to crosscutting issues such as indirect land use change (iLUC) and end-of-life options. The chapters included in this book will provide a comprehensive review of recent works on life cycle assessment (LCA), life cycle costing (LCC) and social life cycle assessment (s-LCA) methodologies. An important resource for researchers, industrial professionals and policy makers involved in the bioeconomy.

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Numerous genetic methods can be utilised to link a phenotype to a single molecular target but annotated small molecule chemical probes and even entire chemogenomic libraries are increasingly being used as a complementary approach. This book will comprehensively cover the state of the art in chemical probes and best practice for use in target discovery, illustrated throughout with examples. Ideal for students and established biochemists, the book will also cover new technologies for probe discovery, new probe modalities, the new field of probes for RNA targets and the mature field of kinase chemical probes.

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Turmeric belongs to the family Zingiberaceae and is a yellow spice of high economic importance due to its medicinal value. Cultivated in tropical and sub-tropical regions around the world, it is used extensively as a colouring, flavouring and preserving agent. In recent years, several drugs derived from natural products have been developed and current drug research is actively investigating the possible therapeutic roles of many Ayurvedic medicines, most notable among those being examined is turmeric. The wide range of pharmacological activities attributed to turmeric come mainly from curcuminoids and two related compounds, demethoxycurcumin and bisdemethoxycurcumin. This comprehensive book brings together the research carried out on constituents obtained from turmeric and highlights their chemical and biological activities. Comprising 17 chapters, each written by experts in their respective field and curated by authorities, it will be invaluable to all those who are involved in the production, processing, marketing, and the use of turmeric. Appealing to researchers and professionals in natural products, nutraceuticals and food chemists, this book is exposing some of the myths and showing areas for possible future use.

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Conversion of light and electricity to chemicals is an important component of a sustainable energy system. The exponential growth in renewable energy generation implies that there will be strong market pull for chemical energy storage technology in the near future, and here carbon dioxide utilization must play a central role. The electrochemical conversion of carbon dioxide is key in achieving these goals. Carbon Dioxide Electrochemistry showcases different advances in the field, and bridges the two worlds of homogeneous and heterogeneous catalysis that are often perceived as in competition in research. Chapters cover homogeneous and heterogeneous electrochemical reduction of CO2, nanostructures for CO2 reduction, hybrid systems for CO2 conversion, electrochemical reactors, theoretical approaches to catalytic reduction of CO2, and photoelectrodes for electrochemical conversion. With internationally well-known editors and authors, this book will appeal to graduate students and researchers in energy, catalysis, chemical engineering and chemistry who work on carbon dioxide.

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Nanoparticles exhibit a range of different properties when compared to bulk materials. Their high surface-area to volume ratio makes them particularly attractive for use as catalysts and recent years have seen an explosion of research in this area. The ability to fine-tune the size and structure of nanoparticles means that it is possible to design catalytic materials for improved activity or specificity. As catalysis is one of the key technologies for more sustainable production of both chemicals and energy, the past few years have seen increasing numbers of nanomaterials reported for these applications. Depending on the application, a number of different catalyst synthesis and optimization protocols can be used. This book provides comprehensive links between the design and fabrication method for nanoparticles and their catalytic performance (activity, selectivity and stability) in various applications. Presenting an introduction to the concept of catalyst design and recent developments in the preparation and characterisation of nanomaterials, followed by several chapters on the design of catalysts for specific applications, this book is a valuable resource for researchers working on catalytic reactions, industrial processes and nanomaterial applications.

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Noncovalent interactions often provide the spine of biomolecular and material structures, and can therefore play a key role in biological and catalytic processes. Selectivity in chemical reactions, particularly in catalytic processes, is often an orchestral action of various noncovalent interactions occurring in intermediates and transition states. Although the role of hydrogen bonding is well explored in catalysis, the other types of weak interactions, namely cation–π, anion–π, π–π stacking, pseudo-agostic, halogen, chalcogen, pnictogen, tetrel and icosagen bonds, must also be considered. Naturally, the chemo-, regio- or stereoselectivity of a reaction depends on the stability of such noncovalent-interaction-supported species in catalytic systems. Therefore, an in-depth understanding of these weak interactions may be the key to designing new catalytic materials. Providing an overview of the role of these different types of noncovalent interactions in both homogenous and heterogeneous catalysis, this book is a valuable resource for synthetic chemists who are interested in exploring and further developing noncovalent-interaction-assisted synthesis and catalysis.

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With a foreword from leading organic chemist Professor Paul Wender, this book collects the major developments reported in the past thirty years in the field of enantioselective reactions promoted by chiral cobalt catalysts, illustrating the power of these green catalysts to provide all types of organic reactions from the basic to completely novel methodologies. The search for new methodologies to prepare optically pure products is one of the most active areas of research in organic synthesis. Of the methods available for preparing chiral compounds, catalytic asymmetric synthesis has attracted the most attention. In particular, asymmetric transition-metal catalysis is a powerful tool for performing reactions in a highly enantioselective fashion. Efforts to develop new asymmetric transformations have previously focused on the use of rare metals such as titanium, palladium, iridium and gold. However, the ever-growing need for environmentally friendly catalytic processes has prompted chemists to focus on the more abundant and less toxic first-row transition metals, such as cobalt, to develop new catalytic systems. The ability of cobalt catalysts to adopt unexpected reaction pathways has led to an impressive number of enantioselective cobalt-promoted transformations being developed over the past three decades. These have included the synthesis of many different types of products, often under relatively mild conditions and with remarkable enantioselectivities. This book is a useful reference resource for chemists, both academic and industrial, working in organic synthesis and interested in greener or more economical catalytic alternatives.

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As analysis, in terms of detection limits and technological innovation, in chemical and biological fields has developed so computational techniques have advanced enabling greater understanding of the data. Indeed, it is now possible to simulate spectral data to an excellent level of accuracy, allowing chemists and biologists access to robust and reliable analytical methodologies both experimentally and theoretically. This work will serve as a definitive overview of the field of computational simulation as applied to analytical chemistry and biology, drawing on recent advances as well as describing essential, established theory. Computational approaches provide additional depth to biochemical problems, as well as offering alternative explanations to atomic scale phenomena. Highlighting the innovative and wide-ranging breakthroughs made by leaders in computational spectrum prediction and the application of computational methodologies to analytical science, this book is for graduates and postgraduate researchers showing how computational analytical methods have become accessible across disciplines. Contributed chapters originate from a group of internationally-recognised leaders in the field, each applying computational techniques to develop our understanding of and supplement the data obtained from experimental analytical science.

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3D printing has rapidly established itself as an essential enabling technology within research and industrial chemistry laboratories. Since the early 2000s, when the first research papers applying this technique began to emerge, the uptake by the chemistry community has been both diverse and extraordinary, and there is little doubt that this fascinating technology will continue to have a major impact upon the chemical sciences going forward. This book provides a timely and extensive review of the reported applications of 3D Printing techniques across all fields of chemical science. Describing, comparing, and contrasting the capabilities of all the current 3D printing technologies, this book provides both background information and reader inspiration, to enable users to fully exploit this developing technology further to advance their research, materials and products. It will be of interest across the chemical sciences in research and industrial laboratories, for chemists and engineers alike, as well as the wider science community.

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Environmental remediation technologies to control or prevent pollution from hazardous waste material is a growing research area in academia and industry, and is a matter of utmost concern to public health, to improve ecology and to facilitate the redevelopment of a contaminated site. Recently, in situ and ex situ remediation technologies have been developed to rectify the contaminated sites, utilizing various tools and devices through physical, chemical, biological, electrical, and thermal processes to restrain, remove, extract, and immobilize mechanisms to minimize the contamination effects. This handbook brings altogether classical and emerging techniques for hazardous wastes, municipal solid wastes and contaminated water sites, combining chemical, biological and engineering control methods to provide a one-stop reference. This handbook presents a comprehensive and thorough description of several remediation techniques for contaminated sites resulting from both natural processes and anthropogenic activities. Providing critical insights into a range of treatments from chemical oxidation, thermal treatment, air sparging, electrokinetic remediation, stabilization/solidification, permeable reactive barriers, thermal desorption and incineration, phytoremediation, biostimulation and bioaugmentation, bioventing and biosparging through ultrasound-assisted remediation methods, electrochemical remediation methods, and nanoremediation, this handbook provides the reader an inclusive and detailed overview and then discusses future research directions. Closing chapters on green sustainable remediation, economics, health and safety issues, and environmental regulations around site remediation will make this a must-have handbook for those working in the field.

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Since the introduction of FT-NMR spectroscopy around five decades ago, NMR has achieved significant advances in hardware and methodologies, accompanied with the enhancement of spectral resolution and signal sensitivity. Rapid developments in the polymers field mean that accurate and quantitative characterization of polymer structures and dynamics is the keystone for precisely regulating and controlling the physical and chemical properties of the polymer. This book specifically focuses on NMR investigation of complex polymers for the polymer community as well as NMR spectroscopists, and will push the development of both fields. It covers the latest advances, for example high field DNP and ultrafast MAS methodologies, and show how these novel NMR methods characterize various synthetic and natural polymers.

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The concept of a circular economy has been gaining increasing attention in recent years. Many of the sources of chemicals we have become reliant on are dwindling and the accumulation of waste products poses a serious environmental problem. By recovering resources from these waste materials, we can reduce our dependence on virgin feedstocks that may not be sustainable as well as reducing the quantity of material going to landfill sites. Incorporating different perspectives from a global authorship, this book aims to introduce systems thinking to the field of waste and resource management. The topics covered range from the use of biogeochemical processes in resource recovery to the application of engineered nanomaterials, with information relevant to both academia and industry. The broad range and cross-disciplinary nature of the topics in this book make it a valuable resource for those working in circular economy research, green chemistry and waste and resource management.

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Recent decades have seen huge growth in the renewable energy sector, spurred on by concerns about climate change and dwindling supplies of fossil fuels. One of the major difficulties raised by an increasing reliance on renewable resources is the inflexibility when it comes to controlling supply in response to demand. For example, solar energy can only be produced during the day. The development of methods for storing the energy produced by renewable sources is therefore crucial to the continued stability of global energy supplies. However, as with all new technology, it is important to consider the environmental impacts as well as the benefits. This book brings together authors from a variety of different backgrounds to explore the state-of-the-art of large-scale energy storage and examine the environmental impacts of the main categories based on the types of energy stored. A valuable resource, not just for those working and researching in the renewable energy sector, but also for policymakers around the world.

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Amino Acids, Peptides and Proteins comprises a comprehensive and critical review of significant developments at the biology and chemistry interface. Compiled by leading researchers in their subject, this volume incorporates current trends and emerging areas in topics ranging from synthetic polypeptide materials and conjugates to membrane proteins and bioactive peptides implicated in various diseases and exploited for drug design. Appealing broadly to researchers in academia and industry, it will be of great benefit to any researcher wanting a succinct reference on developments in this area now and looking to the future.

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CHEMISTRY STUDENT GUIDES. GUIDED BY STUDENTS Why did the drug thalidomide cause birth defects? What is the chemical difference between sucrose and lactose in your food? Stereochemistry holds the answer and is essential to the understanding of the chemistry of life. Stereochemistry is an important concept that often causes confusion amongst students when they learn it for the first time. Unlike most other areas of chemistry, it requires the chemist to visualise molecules in 3D, which can be difficult. In this book we deal with tricky concepts like conformation and configuration, how to represent them accurately and how to use the correct terms to describe them in both organic and inorganic chemistry. We involved students in the writing process to ensure we deal with areas that you find difficult, in an understandable language. With problems designed to focus on common errors and misconceptions, real life examples, and practical hands-on exercises coupled with visualisation tips, our intention is to give you the tools to become confident in stererochemistry. Complementing mainstream organic textbooks, or self-study, this book is for anyone who has struggled with describing alkenes as E or Z, assigning R and S absolute configurations, drawing Newman projections or chair representations of cyclohexanes, axial chirality, understanding the stereochemistry of octahedral metal complexes and indeed explaining complexities observed in NMR spectra. Chemistry Student Guides are written with current students involved at every stage, guiding the books towards the most challenging aspects of the topic. Student co-authors for Introduction to Stereochemistry are Caroline Akamune, Michael Lloyd and Matthew Taylor.

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Carotenoids are found in some food plants, flowers and animals, in free form and also esterified with fatty acids. Recent research has concentrated on the extent of carotenoid esters in these sources, how to assess their presence and the amount available for potential health effects. Focusing on the occurrence and assembly in foods, biosynthesis, analytical methods for identification and quantification, dietary intake and metabolism, the most recent research is represented and a balanced overview of what is known about carotenoid esters is provided. As the first book to address this topic in a comprehensive way, it ensures a better understanding of the importance of carotenoid esters to both food and health, and provides one source for researchers in food science, nutrition, natural products and the food and pharmaceutical industries. Carotenoid Esters in Foods will be a valued addition to the literature, specifically for those conducting research into carotenoids and carotenoid esters in foods. It is a unique contribution and a must-have source for those in this community.

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The Medicinal Chemist’s Guide to Solving ADMET Challenges summarizes a series of design strategies and tactics that have been successfully employed across pharmaceutical and academic laboratories to solve common ADMET issues. These are exemplified with a curated collection of concrete examples displayed in a highly visual “table-of-contents” style format, allowing readers to rapidly identify the most promising approaches applicable to their own challenges. Each ADMET parameter is introduced in a concise yet comprehensive manner and includes background, relevance and screening strategies. Medicinal chemistry knowledge of how best to modify molecular structure to solve ADMET issues is challenging to retrieve from the literature, public databases and even corporate data warehouses. The Medicinal Chemist’s Guide to Solving ADMET Challenges addresses this gap by presenting state-of-the-art design strategies put together by a global group of experienced medicinal chemists and ADMET experts across academia and the pharmaceutical industry.

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Many studies have highlighted the importance of discourse in scientific understanding. Argumentation is a form of scientific discourse that plays a central role in the building of explanations, models and theories. Scientists use arguments to relate the evidence that they select from their investigations and to justify the claims that they make about their observations. The implication is that argumentation is a scientific habit of mind that needs to be appropriated by students and explicitly taught through suitable instruction. Edited by Sibel Erduran, an internationally recognised expert in chemistry education, this book brings together leading researchers to draw attention to research, policy and practice around the inclusion of argumentation in chemistry education. Split into three sections: Research on Argumentation in Chemistry Education, Resources and Strategies on Argumentation in Chemistry Education, and Argumentation in Context, this book blends practical resources and strategies with research-based evidence. The book contains state of the art research and offers educators a balanced perspective on the theory and practice of argumentation in chemistry education.

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Green chemistry has progressed from being a driver for change in the chemical and allied industries to being a critical part of chemical education at all levels. The future chemist must be able to practice their trade in the light of increasing concerns about waste and resources, the safety of chemicals in consumer products, and increasingly restrictive legislation. While there are green chemistry educational resources available including lectures and experiments as well as numerous books on green chemistry and major green chemical technologies, there is no “green equivalent” of a standard organic chemistry textbook Systematically covering a variety of well-known reactions that commonly feature in standard organic textbooks this book supplements and supports the standard organic chemistry texts. It highlights the main sustainability issues of classical and contemporary organic transformations and critically evaluates them within a metric of established Green Chemistry Principles noting where additional efforts are needed to improve their environmental footprint. Written by a team of expert authors with a multinational advisory board, this book is a fantastic resource for advanced undergraduate and postgraduate students worldwide.

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New genomic information has revealed the crucial role that protein–protein interactions (PPIs) play in regulating numerous cellular functions. Aberrant forms of these interactions are common in numerous diseases and thus PPIs have emerged as a vast class of critical drug targets. Despite the importance of PPIs in biology, it has been extremely challenging to convert targets into therapeutics and targeting PPIs had long been considered a very difficult task. However, over the past decade the field has advanced with increasing growth in the number of successful PPI regulators. Protein–Protein Interaction Regulators surveys the latest advances in the structural understanding of PPIs as well as recent developments in modulator discovery.

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Globally, cereal grains are a staple part of the diet providing primarily carbohydrates and other phytochemical components. Detailed coverage of the composition and functionality of the bulk carbohydrate components, specifically starch, beta-glucans, and arabinoxylans, and the trace phytochemical components, i.e. phenolic compounds such as phenolic acids, anthocyanins, deoxyanthocyanins, and proanthocyanidins in cereal grains and grain products is provided. Considerable attention is paid to the interactions between carbohydrate and non-carbohydrate components in grains including starch–protein and starch–lipid interactions and their effects on starch digestibility. The phenolic constituents bound to grain dietary fiber also receive detailed consideration and the final chapter presents a review that discusses whole grain–gut microbiota interactions identifying new areas of research that may contribute to a better understanding of the underlying mechanisms linked to human health. This book provides researchers, clinicians and students with a comprehensive compendium on aspects of whole grain components and brings the literature up to date.

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Ten years after the first volume, this book highlights the important contribution Raman spectroscopy makes as a non-destructive method for characterising the chemical composition of objects with archaeological and historical importance. The original book was ground-breaking in its concept, but the past ten years have seen some advancement into new areas, consolidation of some of the older ones and novel applications involving portable instrumentation, on site in museums and in the field. This new volume maintains the topic at the cutting edge, the Editors have approached prominent contributors to provide case-studies sorted into themes. Starting with a Foreword from the British Museum Director of Scientific Research and an Introduction from the Editors, which offer general background information and theoretical context, the contributions then provide global perspectives on this powerful analytical tool. Aimed at scientists involved in conservation, conservators and curators who want to better understand their collections at a material level and researchers of cultural heritage.

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Food fraudsters be warned! Sophisticated science was at the centre of detecting and prosecuting this new crime of food fraud. The ground-breaking case, a first of its kind, needed new sentencing guidelines for judges, new working arrangements for prosecutors and police and an EU-wide agreement on techniques and standards used for prosecution, which were agreed on the hoof in response to a crime detected in over 40 countries. In 2013 thousands of consumers, retailers and food businesses were ripped-off by insiders - thieves who substituted and sold horse-meat in place of beef. They used a web of deception that involved unwitting suppliers passing off their fraudulent produce to some of Britain’s largest retailers and international food business. Following so-called Horsegate, the enforcement world had to change. There is now a team focussing on food fraud and a desire to put the perpetrators behind bars. Much tougher sanctions have been introduced with the aim of discouraging such crimes. This book is a timely look at the web of deception and how it can be stopped. Aimed at food enforcement professionals, lay readers with an interest in crime, students studying food fraud, criminology or forensics and anyone who eats food. Once again, life emulated art, this deception mirrors the story of the thief who came to dinner, gained inside knowledge and stole priceless artefacts from the host. So, who will come to dinner next time? This is the second book by the author, a scientist sharing his inside knowledge on this food crime.

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The increased understanding of molecular aspects associated with chronic diseases, such as cancer and the role of tumor microenvironment, has led to the identification of endogenous and exogenous stimuli that can be exploited to devise “stimuli-responsive” materials for site-specific drug delivery applications. This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials. Setting the scene, the editors open with a chapter addressing the need for smart materials in delivery applications for therapy, imaging and disease diagnosis. The following chapter describes the key physical and chemical aspects of smart materials, from lipids to polymers to hybrid materials, providing the reader with a springboard to delve into the more application oriented chapters that follow. With in-depth coverage of key drug delivery systems such as pH-responsive, temperature responsive, enzyme-responsive and light responsive systems, this book provides a rigorous foundation to the field. A perfect resource for graduate students and newcomers, the closing chapter on regulatory and commercialization challenges also makes the book ideal for those wanting to take the next step towards clinical translation.

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Inorganic solid adsorbents/sorbents are attractive materials for capturing carbon dioxide (CO2) from flue gases after fossil fuel combustion. Post-combustion Carbon Dioxide Capture Materials introduces the key inorganic materials used as adsorbents/sorbents with specific emphasis on their design, synthesis, characterization, performance, and mechanism. Dedicated chapters cover carbon-based adsorbents, zeolite- and silica-based adsorbents, metal–organic framework (MOF)-based adsorbents, and alkali-metal-carbonate-based adsorbents. The final chapter discusses the practical application aspects of these adsorbents used in carbon dioxide capture from flue gases. Edited and written by world-renowned scientists in each class of the specific material, this book will provide a comprehensive introduction for advanced undergraduates, postgraduates and researchers from both academic and industrial fields wishing to learn about the topic.

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Using inorganic solid adsorbents/sorbents is a promising approach for carbon dioxide (CO2) capture and is attracting intense attention from both academic and industrial fields. Pre-combustion Carbon Dioxide Capture Materials presents a range of the different inorganic materials that can be used as pre-combustion CO2 adsorbents/sorbents with specific emphasis on their design, synthesis, characterization, performance, and mechanism. Dedicated chapters cover layered double hydroxide (LDH) derived adsorbents, MgO-based adsorbents, CaO-based sorbents and alkali ceramics based sorbents. Edited and written by world-renowned scientists in each class of CO2 capture material, this book will provide a comprehensive introduction for advanced undergraduates, postgraduates and researchers wishing to learn about the topic.

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