Search results for ""author leonard"

With the increasing use of immune checkpoint inhibitors (ICI) across various cancers, the trends for indication at earlier stages, and the use of combination immunotherapy, the frequency of ICI-induced immune-related adverse events (irAE) is expected to grow substantially. Management of these irAE is challenging as it requires not only consideration of the toxicity but also risk-benefit ratios with respect to the primary cancer. Several rheumatic irAE have been reported with ICI therapy including arthritis, myositis, polymyalgia-like syndromes, sicca/Sjogren-like manifestations, and several other less common systemic autoimmune features commonly associated with connective tissue disease. This handbook provides clinicians with a comprehensive overview of the management of rheumatic irAE that develop from cancer immunotherapy. It focuses on the irAE seen with ICI, the most frequently used agents in treating cancer. It provides an overview of cancer immunology, immunotoxicity, and immunotherapies such as ICI, cytokine-based therapy, and CART. It examines the epidemiology, clinical manifestations, diagnosis, differential diagnosis, and treatment of a variety of rheumatic immune-related adverse events arising from these therapies. Chapters also cover cancer immunotherapy in patients with preexisting rheumatic diseases such as inflammatory arthritis and other connective tissue disorders. The book helps clinicians to distinguish the current types of cancer immunotherapy and general toxicity patterns, recognize and diagnose rheumatic clinical syndromes, understand the pathogenesis of irAE, and consider risk–benefit ratios when managing patients with rheumatic irAE.Rheumatic Diseases and Syndromes Induced by Cancer Immunotherapy is an essential resource for physicians and related professionals, residents, fellows, graduate students and nurses alike in rheumatology, clinical immunology, oncology, and internal medicine.

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This season, add a new classic to your holiday collection with this heartwarming Christmas picture book about a little boy who learns there's more to Christmas than being on the naughty or nice list.Dear Santa, Let me explain…Parker knows he is definitely not perfect. Everyone makes mistakes, and it's tough being a kid! So when Ms. Holly asks the class to write their letters to Santa, Parker gets nervous. Why are all of his friends telling Santa how perfect they are? Santa knows if you've been bad or good… It's best to be honest. Right? Parker hands in his honest letter and hopes that Santa will understand. When Christmas morning arrives, Parker finds a big surprise under the tree—and a letter from Santa!Includes special stationery to write your own letter to Santa. PLUS, get a FREE PERSONALIZED letter from Santa!BONUS: Kids can write a letter to Santa using the festive holiday-themed stationery included in every book. Parents can also visit Put Me In the Story for a FREE downloadable personalized letter from the desk of Santa Claus, or get a letter and official 'Nice List' certificate sent in a magical envelope all the way from the North Pole! It's never been easier to make your child's Christmas wishes come true than with this activity for kids!

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Trust this market-leading text to give you a thorough introduction to mathematics methods and concepts and provide you with a practical resource guide to teaching grade K���6 mathematics. The text contains over 275 detailed lesson activities for easy-to-implement classroom use. Each activity is also linked to related Common Core Content Standards and Mathematical Practice. Other useful features highlight common student misconceptions about math operations and concepts, tips for being inclusive of students from various cultural backgrounds, and excellent math-related children's literature to use in the classroom. The text is available with MindTap, an online learning experience that guides you to learn concepts and skills critical to becoming a great teacher, and includes useful apps and an eportfolio.

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Digital retinal imaging performed by primary care providers and nurses, followed by remote image interpretation (teleretinal imaging), is rapidly acquiring a crucial role in many parts of the world as it permits the detection of major diseases, such as diabetic retinopathy and glaucoma, in patients who would otherwise be beyond the reach of a trained ophthalmologist. In this book, experts from around the world describe how digital teleretinal screening can be set up and optimally utilized. Technical issues are discussed, and the appropriate use of screening for different diseases and in different age groups is explained. The major part of the book draws upon the clinical experience of leading practitioners in a wide range of teleretinal applications. The result is a comprehensive source of high-quality information for clinicians and other health professionals who are involved in eye care delivery, so that they can assess how teleretinal screening might be applied to their working practice.

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This book covers the theory, design and applications of computer networks, distributed computing and information systems. Networks of today are going through a rapid evolution, and there are many emerging areas of information networking and their applications. Heterogeneous networking supported by recent technological advances in low-power wireless communications along with silicon integration of various functionalities such as sensing, communications, intelligence and actuations is emerging as a critically important disruptive computer class based on a new platform, networking structure and interface that enable novel, low-cost and high-volume applications. Several of such applications have been difficult to realize because of many interconnections problems. To fulfill their large range of applications, different kinds of networks need to collaborate, and wired and next generation wireless systems should be integrated in order to develop high-performance computing solutions to problems arising from the complexities of these networks. The aim of the book “Advanced Information Networking and Applications” is to provide the latest research findings, innovative research results, methods and development techniques from both theoretical and practical perspectives related to the emerging areas of information networking and applications.

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"Complex Intelligent Systems and Applications" presents the most up-to-date advances in complex, software intensive and intelligent systems. Each self-contained chapter is the contribution of distinguished experts in areas of research relevant to the study of complex, intelligent, and software intensive systems. These contributions focus on the resolution of complex problems from areas of networking, optimization and artificial intelligence. The book is divided into three parts focusing on complex intelligent network systems, efficient resource management in complex systems, and artificial data mining systems. Through the presentation of these diverse areas of application, the volume provides insights into the multidisciplinary nature of complex problems. Throughout the entire book, special emphasis is placed on optimization and efficiency in resource management, network interaction, and intelligent system design. This book presents the most recent interdisciplinary results in this area of research and can serve as a valuable tool for researchers interested in defining and resolving the types of complex problems that arise in networking, optimization, and artificial intelligence.

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Written for the design professional, this book offers basic concepts for site security design and risk/threat assessment, and their relationship and integration into the overall design/streetscape projects. * This book is the only reference to offer coverage of security design for the site, rather than for the building * It provides landscape architects and other design professionals with the fundamental knowledge they need in order to work with clients and security consultants * It includes guidelines for conducting security/risk assessments as well as case studies that offer a variety of site designs that successfully integrate security

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Heavy Radicals: The FBI's Secret War on America's Maoists is a history of the Revolutionary Union/Revolutionary Communist Party - the largest Maoist organization to arise in the US - from its origins in the explosive year of 1968, its expansion into a national organization in the early '70s, its extension into major industry throughout the early part of that decade, and the devastating schism in the aftermath of the death of Mao Tse-tung to its ultimate decline as the 1970s turned into the 1980s. From its beginnings the grouping was the focus of J. Edgar Hoover and other top FBI officials for an unrelenting array of operations: Informant penetration, setting organizations against each other, setting up phony communist collectives for infiltration and disruption, planting of phone taps and microphones in apartments, break-ins to steal membership lists, the use of FBI ‘friendly journalists’ such as Victor Riesel and Ed Montgomery to undermine the group, and much more. It is the story of a sizable section of the radicalized youth whose radicalism did not disappear at the end of the '60s, and of the FBI’s largest - and, up to now, untold - campaign against it.

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This book offers African, Asian, Latin American, European, and North American perspectives on institutions and regulations promoting sustainable economic growth in the post-2015 development agenda in areas such as environment, labour, risk management, corporate social responsibility, corporate governance, and innovation. The chapters address sustainability issues at the firm, national, regional and international levels from a multidisciplinary perspective. The chapters of this volume address the challenge of enhancing economic competitiveness of the supply side economies while pushing a sustainable development agenda. This work addresses the existing inequalities, environmental degradation, and economic/financial instability under current dynamics of international and domestic power relations in order to meet the set objectives for the post-2015 era. This volume advances the perspectives on the non-compulsory alternative to markets regulations, the United Nations Global Compact, explored in the previous volume 'The UN Global Compact: Fair Competition and Environmental and Labour Justice in International Markets' vol. 16.

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The studies in this collection re-examine the role of the Qing state in the private economy. They show in a variety of cases how the interaction between the two helped the state achieve its goals of social stability and security while enhancing the prosperity of private economic interests.

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From #Gamergate to the 2016 election, to the daily experiences of marginalized perspectives, gaming is entangled with mainstream cultures of systematic exploitation and oppression. Whether visible in the persistent color line that shapes the production, dissemination, and legitimization of dominant stereotypes within the industry itself, or in the dehumanizing representations often found within game spaces, many video games perpetuate injustice and mirror the inequities and violence that permeate society as a whole. Drawing from groundbreaking research on counter and oppositional gaming and from popular games such as World of Warcraft and Tomb Raider, Woke Gaming examines resistance to problematic spaces of violence, discrimination, and microaggressions in gaming culture. The contributors of these essays seek to identify strategies to detox gaming culture and orient players and gamers toward progressive ends. From Anna Anthropy’s Keep Me Occupied to Momo Pixel’s Hair Nah, video games can reveal the power and potential for marginalized communities to resist, and otherwise challenge dehumanizing representations inside and outside of game spaces. In a moment of #MeToo, #BlackLivesMatter, and efforts to transform current political realities, Woke Gaming illustrates the power and potential of video games to foster change and become a catalyst for social justice.

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This book covers the theory, design and applications of computer networks, distributed computing and information systems. Networks of today are going through a rapid evolution, and there are many emerging areas of information networking and their applications. Heterogeneous networking supported by recent technological advances in low-power wireless communications along with silicon integration of various functionalities such as sensing, communications, intelligence and actuations is emerging as a critically important disruptive computer class based on a new platform, networking structure and interface that enable novel, low-cost and high-volume applications. Several of such applications have been difficult to realize because of many interconnections problems. To fulfill their large range of applications, different kinds of networks need to collaborate, and wired and next generation wireless systems should be integrated in order to develop high-performance computing solutions to problems arising from the complexities of these networks. The aim of the book “Advanced Information Networking and Applications” is to provide the latest research findings, innovative research results, methods and development techniques from both theoretical and practical perspectives related to the emerging areas of information networking and applications.

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A Stanford University Press classic.

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Sometime in the late fall/early winter of 1962, a document began circulating among members of the Communist Party USA based in the Chicago area, titled "Whither the Party of Lenin." It was signed "The Ad Hoc Committee for Scientific Socialist Line." This was not the work of factionally inclined CP comrades, but rather something springing from the counter-intelligence imagination of the FBI. A Threat of the First Magnitude tells the story of the FBI's fake Maoist organization and the informants they used to penetrate the highest levels of the Communist Party USA, the Black Panther Party, the Revolutionary Union and other groups labelled threats to the internal security of the United States in the 1960s and 1970s. As once again the FBI is thrust into the spotlight of US politics, A Threat of a First Magnitude offers a view of the historic inner-workings of the Bureau's counterintelligence operations - from generating "fake news" and the utilization of "sensitive intelligence methods" to the handling of "reliable sources" - that matches or exceeds the sophistication of any contenders.

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This is by a large degree the most comprehensive accounting of the games of this brilliant chess player. Presented are 2,543 of Alekhine’s games, in an exhaustive catalog that is the result of many years of digging—an effort unparalleled in the history of chess game collections. Many of the games are annotated by Alekhine and 1,868 diagrams appear overall. The book includes games from his earliest correspondence tournaments in 1902 through his final match with Francisco Lupi at Estoril, Portugal, in January 1946.

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Metal-Organic Frameworks (MOFs) are crystalline compounds consisting of rigid organic molecules held together and organized by metal ions or clusters. Special interests in these materials arise from the fact that many are highly porous and can be used for storage of small molecules, for example H2 or CO2. Consequently, the materials are ideal candidates for a wide range of applications including gas storage, separation technologies and catalysis. Potential applications include the storage of hydrogen for fuel-cell cars, and the removal and storage of carbon dioxide in sustainable technical processes. MOFs offer the inorganic chemist and materials scientist a wide range of new synthetic possibilities and open the doors to new and exciting basic research. Metal-Organic Frameworks Materials provides a solid basis for the understanding of MOFs and insights into new inorganic materials structures and properties. The volume also reflects progress that has been made in recent years, presenting a wide range of new applications including state-of-the art developments in the promising technology for alternative fuels. The comprehensive volume investigates structures, symmetry, supramolecular chemistry, surface engineering, recognition, properties, and reactions. The content from this book will be added online to the Encyclopedia of Inorganic and Bioinorganic Chemistry: http://www.wileyonlinelibrary.com/ref/eibc

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First published in 1982, this text is widely regarded as a leading general history of the country. This new and revised edition brings the story of this fascinating country up to date, incorporating the latest scholarship on every period of Malaysian history, including recent research into pre-modern times. This text thus provides a historical framework that helps explain the roots of the issues dominating Malaysian life today, and the difficulties of creating a multicultural state where resources are equitably shared and the rights of all citizens are acknowledged. This book is a key text for courses on Southeast Asian history and politics. Covering a range of disciplinary subjects in the humanities and social sciences, it is also useful for anyone interested in the assessment of young, modernizing nations. New to this Edition: - A new chapter provides insights into Malaysian history of the last 15 years, including the growing influence of the internet and social media in the political sphere - Greater attention is paid to the strengthening of civil society movements that have arisen in light of perceived government failures - Fresh analysis of Islam's historical role in the Malay world and how it links with the growing Islamization of Malaysia today

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System wide health reform has become the norm across the globe, forcing health care delivery organizations to critically examine the ways in which they are structured and operate on a day to day basis. Resource scarcity has become common while at the same time, quality and clinical outcomes become the basis upon which these organizations are measured and compared with one another. This volume of "Advances in Health Care Management" includes contributions from key academic thought leaders from around the world who critically examine how health reform impacts the macro, meso and micro level strategy and policy decisions of healthcare organizations.

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This book is a specially published section of the larger work ICE Manual of Construction Materials, an invaluable resource for practising civil and structural engineers in consulting firms, government agencies, research institutes, universities and colleges. Its highly practical approach will guide and train readers towards achieving expertise in the use of major and emerging construction materials. The Polymers and Polymer Fibre Composite section of the two-volume manual is edited by Christopher Hall, Jian-Fei Chen and Len Hollaway.

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NEW! Case studies for the Next Generation NCLEX®. NEW! Content on COVID-19 includes current recommendations from professional organizations related to vaccines and the care of pregnant women and newborns. UPDATED! Increased coverage of the needs of nontraditional families. UPDATED! Coverage of legislative changes that affect health care delivery in the United States. UPDATED! Current recommendations and practice changes from professional organizations, such as the American College of Obstetricians and Gynecologists (ACOG), the Association for Women's Health, Obstetric and Neonatal Nurses (AWHONN), and the American Academy of Pediatrics (AAP). UPDATED! Enhanced content on client- and family-centered care focuses on diversity and cultural assessment. UPDATED! Added emphasis on racial disparities in relation to women's health and childbearing. UPDATED! Cutting-edge content on treatments for breast cancer.

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