Search results for ""Royal Society of Chemistry""

Recent discussions among scientists and policy-makers have highlighted that knowledge generated by many research and demonstration projects is not reaching policymakers in an efficient way. Conversely, the consideration of research results by the policy making community is not straightforward, and difficulties arise in integrating the latest research developments in legislation. The difficulty is enhanced by the fact that the policy-making community is not defining its role as "client" sufficiently well and the dialogue and communication channels are far from ideal to ensure an efficient flow of information. An increasing number of experts consider that improvements could be achieved through the development of a "science-policy interface" so that R&D results are synthesised in a way to efficiently feed policy implementation and that short, medium and long term research needs may be identified. This book examines the issue of integrating science into policy, with an emphasis on water system knowledge and related policies. An important feature of the book is the discussion of science-policy interfacing needs, illustrated by examples from authors from different countries in relation to water system management. This publication is timely in that the science-policy interfacing is now identified as a key challenge worldwide with regard to integrated water resource management, and therefore the book will be of great interest to scientists, water managers and stakeholders. Readers will also benefit from a better understanding of the needs, benefits and drawbacks of an established transfer mechanism of scientific outputs to policies.

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This book explains to the general reader the roles of chemistry in various areas of life ranging from the entirely personal to the worryingly global. These roles are currently not widely appreciated and certainly not well understood. The book is aimed at educated laypeople who want to know more about the world around them but have little chemical knowledge. The themes relate to the importance of chemistry in everyday life, the benefits they currently bring, and how their use can continue on a sustainable basis. Topics include: Health - conquering the diseases and stresses which still threaten us. Food - the role of agrochemicals and food chemists. Water - drinking water; the seas as a resource of raw materials. Fuels - what are they and from what are they made? Plastics - what are the used for and can they be sustainable? Cities - what role has chemistry in modern life? Sport - chemistry has changed the game. The world stands at a crossroads. What route to the future should we take? The road to a sustainable city beckons, but what effect will this have on chemistry, which appears so dependent on fossil resources? Its products are part of everyday living, and without them we could regress to the world of earlier generations when lives were blighted by disease, famines, dirt, and pain. In fact the industries based on chemistry the chemical, agrochemical, and pharmaceutical industries could be sustainable and not only benefit those in the developed world but could be shared by everyone on this planet and for generations to come. This book shows how it might be achieved.

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Polymer nanocomposites revolutionized research in the composites area by achieving the nanoscale dispersion of the inorganic filler (clay platelets) in the polymer matrices after suitable surface modifications of the filler phase. A large number of polymer matrices were tried and nanocomposites with varying degrees of successes were achieved with these polymer systems. The majority of the synthesis are carried out by melt blending which frequently result in the full exfoliation of the filler. However, advanced techniques provide a number of advantages as compared to the melt blending and lead to more uniform composites with enhanced properties. There are a number of recent advances in these methods such as the use of reactive surfactants, modified initiators, advanced clay surface modifications, use of a variety of fillers, inverse polymerization, and miniemulsion polymerization methods which have further led the generation of advanced exfoliated nanocomposites. Until now, most of the published research has been scattered throughout the literature. This book provides a single comprehensive source of information about one of the most important facets of polymer nanocomposites technology: synthesis in emulsion and suspension. These polymerization methods lead to the generation of the well delaminated polymer nanocomposites with a wide range of polymer matrices. This book serves as both a professional reference for experienced researchers and a valuable text for newcomers to the field. It makes the reader aware of the potential commercial use of these recent developments.

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This book will cover all the major ion-battery groups and their electrolytes. It is suitable for all levels of students and researchers who want to understand the fundamentals and future challenges of developing electrolytes.

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Antibiotic resistance is a global health concern. Strains of pathogenic microorganisms that have developed resistance to multiple antibiotics, such as MRSA, are extremely difficult to treat, and alternative methods for tackling pathogenic microorganisms are in demand. One potential target for new therapeutics is inhibition of quorum sensing: how microorganisms communicate and form biofilms in a density-dependent manner. Inhibiting this system via ‘quorum quenching’ (QQ) is a promising route to new pharmaceuticals and for controlling biofilm formation and growth. Quorum sensing also provides interesting possibilities in synthetic biology for producing novel products, biosensors, bioactive molecules, and so on. This book covers the biology of quorum sensing and quenching, and potential sources of QQ enzymes and other inhibitors, as well as an overview of their mechanism and potential biotech applications. The book also covers the potential for new drug development from QQ, covering a range of related topics including protein engineering, imaging and computational studies, and integrated systems. This book is an ideal companion to researchers in chemical biology and medicinal chemistry, particularly those interested in biofilm formation, quorum sensing, novel antimicrobial development, synthetic biology and enzymology.

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Hydrogels are highly hydrated three dimensional networks with the ability to mimic the extracellular matrix of bodily tissues and have thus found application in a wide range of biomedical applications. Unique physiochemical properties such as biocompatibility, water permeability, stimuli responsiveness and self-healing characteristics make them especially useful for use as scaffolds and matrices drug delivery, tissue engineering/regeneration and sensing. Their weak and brittle nature, however, often limits their widespread application where improved mechanical strength is required. To resolve this problem, there has been a significant amount of research into the improvement of their mechanical properties. Among these efforts, versatile multicomponent hydrogels have received much attention as their physiochemical properties can be structurally engineered to provide a wide range of desired properties. These multicomponent formulations also allow for the combination of natural and synthetic polymers, which offers the scope to exploit the advantages of each component, with the synergistic effects resulting from mutual interactions. This book critically discusses the fundamental chemistry, synthesis, characterisation, physiochemical and biological properties of various types of multicomponent hydrogels. It reviews the different strategies employed in designing and synthesizing cutting-edge multicomponent hydrogels and their key applications in biomedical fields. The work is suitable for researchers working in the specific area of multicomponent hydrogels, and also more generally for those working in materials science, biomedical engineering, biomaterials science and tissue engineering.

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Hair analysis is a reliable and widely used tool to evaluate drug exposure in many fields, including workplace testing, drug abuse history and withdrawal control, post-mortem toxicology, doping control, therapeutic drug monitoring of pharmaceuticals and even environmental exposure to toxic agents. Compounds incorporated into the hair structure resist hair growth and regular washing for several months, leading to a potential chronological trace of exposure, with farther periods corresponding to the hair segments more distant from the hair root. The relentless improvement of analytical procedures and instrumental technologies, together with the continuous introduction of new psychoactive substances, have led to an increasing number of studies and practical applications of hair analysis. This book is a comprehensive guide to hair analysis from general concepts, ideal for students and those new to the field, to interpretation and advanced methods for experts working in the area. With contributions from world-leading scientists in each field, this book describes state-of-the-art, emerging issues and recent analytical approaches to hair analysis that will serve as an essential tool to clinical and forensic toxicology laboratories across the globe.

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Discussing the issue of male germline mutagenesis and the effects on developmental defects in the next generation, this book provides analysis of the fundamental mechanisms of mutations covering both clinical and experimental aspects.

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The publications in nanoscience cross conventional boundaries from chemistry to specialised areas of physics and nanomedicine. With such a vast landscape of material, careful distillation of the most important discoveries helps researchers find the key information. Nanoscience provides a critical and comprehensive assessment of the most recent research and opinion from across the globe. Topics covered in this volume include nanomaterials for electro-organic synthesis, porous organic polymers for CO2 reduction, nanoporous carbons and their potential energy storage applications and MOF derived nanostructures for heterogeneous catalysis. Appealing to anyone practising in nano-allied fields or wishing to enter the nano-world, this useful resource provides a succinct reference on recent developments in this area now and looking to the future.

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This book consists of a series of lectures introducing what the author believes to be the theoretical minimum for the understanding of nuclear spin dynamics, the branch of physics underpinning magnetic resonance techniques such as NMR and MRI. Spin dynamics ultimately concern the study of the state and time evolution of systems made by a large collection of particles possessing spin, one of the most subtle and indeed fascinating concepts in relativistic quantum mechanics and whose understanding requires a mix of quantum mechanics, Hamiltonian dynamics and advanced mathematics. Written in the concise and direct style appropriate for university lectures, this book is addressed to both undergraduate and postgraduate students who are approaching magnetic resonance studies and want to reach the theoretical minimum required to understand the wider topic and its main applications. The book is suitable for researchers who work in the field of magnetic resonance and want to know more about its theoretical fundamentals. Finally, built as a complete set of 12 lectures and 4 workshops, the book can act as a solid reference to lecturers of magnetic resonance university modules. Trained in a world-leading research laboratory internationally recognised for its contributions to the NMR field, the author has a track record in theoretical and methodological developments of nuclear spin dynamics. In this book, he tries to merge his passion for the understanding of physics through its mathematical rendering with his personal quest for the elegance of a clean, clear and satisfactory explanation.

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Microalgae are a diverse set of eukaryotic photosynthetic organisms with great potential for being used to produce various high-value molecules. Using synthetic biology to manipulate and control the metabolic processes of microalgae, scientists hope to find economical and sustainable alternatives for commercial production of high value biochemicals and other metabolites for diverse applications. Highlighting the immense potential of microalgae as a renewable and sustainable source of commercially important, high-value biomolecules, this book covers the recent advances in the resources, tools, and techniques used for genetic engineering of microalgae. Also discussed are the legislative challenges associated with genetically engineered microalgae, their derived products and their uses, as well as socio-economic and environmental acceptance. Written to be accessible to a wide audience, this book will be a useful reference to students and researchers from both academia and industry, as well as policy makers, for understanding the current status, trends and future possibilities of using microalgae for biotechnological applications.

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Residual dipolar couplings (RDCs) are NMR measurements widely used to determine structural and dynamic information in small molecules and large macromolecules. This book provides a broad view of RDCs, from basic principles to advanced applications in organic molecules and biomolecules. Exploring the newest developments in RDC measurement and analysis through authoritative accounts written by leaders in the field, this book provides a comprehensive overview on the fundamentals, analysis and applications in one place for the first time. The versatility and accuracy of RDCs have found a large range of applications in NMR, and their measurement and analysis are major research areas. Readers, be they experts or students, will receive a strong understanding of the fundamentals of RDCs and their applications to their research projects.

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There is growing interest in the food, supplements, cosmetics, and pharmaceutical industries in improving the healthiness of their products by incorporating lipophilic bioactive substances like oil-soluble vitamins (A, D and E), omega-3 fatty acids, and nutraceuticals (carotenoids, curcuminoids and flavonoids). However, there are many challenges that need to be overcome due to their poor water-solubility, chemical stability, and bioavailability. For this reason, there is interest in the development of effective encapsulation technologies to increase the efficacy of lipophilic bioactives. This book reviews the encapsulation systems currently available for delivering lipophilic bioactives, including their preparation, functionality, and application range, including nanoemulsions, emulsions, Pickering emulsions, HIPEs, microgels, organogels and liposomes. Chapters 1-2 review the biological activity of delivery systems and lipophilic bioactives. Chapters 3-5 describe the materials and preparation methods used to assemble delivery systems. Chapters 6-17 focus on the formation and application of different kinds of delivery systems. Chapter 18 discusses future trends in the development of bioactive delivery systems. Edited and authored by world renowned scholars, the book provides a state-of-the-art overview of the design, fabrication, and utilization of delivery systems for bioactives that will be useful for academic, government, and industrial scientists in fields such as pharmaceuticals, cosmetics, agriculture, chemical engineering, nutrition, and foods.

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From DNA and RNA to proteins and vitamins the role of nitrogen is central in organismal metabolism. The Chemical Biology of Nitrogen comprehensively examines how the chemistry available to both inorganic and organic nitrogen compounds both enable and conditions the vast array of nitrogen biologies. This book provides a chemocentric approach to both the inorganic and organic chemical biology of nitrogen. Following an introduction to nitrogen trivalency the book progresses through the logic of inorganic nitrogen metabolism and organic nitrogen metabolites to nitrogen proteomics with an integrative approach to understanding the role of nitrogen in its many biologic roles. Authored by a renowned scientist and educator, this book is ideal for researchers in chemical biology and nitrogen metabolism and will be of particular interest to advanced students and postgraduates in biochemistry and chemical biology.

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In many fields, most notably medicine and molecular biology, the understanding of the structure and function of carbohydrates and glycoconjugates remains vital. This new volume contains critical reviews covering the latest findings in both chemical and biological sciences, and demonstrates the interdisciplinary nature of modern carbohydrate research. This book addresses diverse applications that continue to be major challenges for carbohydrate chemists. The book starts with a review of Gérard Descotes contribution to the field as a pioneer of French modern carbohydrate chemistry. Green nanocatalytic oxidation of free sugars, photosensitive glycomacrocycles, the application of disaccharides in supramolecular chemistry, recent advances in the radiation chemistry of polysaccharides, and the cell wall pectic rhamnogalacturonan II, an enigma in plant glycobiology are just some of the diverse topics presented in Volume 45. This set of reports will certainly benefit any researcher who wishes to learn about the latest developments in the carbohydrate field.

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Rapid population growth, urbanisation and industrialisation have caused serious problems in terms of water pollution and the supply of safe water. Solutions for monitoring pollutants in water and for removing them are urgently needed and they must be both efficient and sustainable. Recent advances in emerging environmental nanotechnologies provide promising solutions for these issues. The physical and chemical properties of nanomaterials can be tailored by controlling attributes such as their size, shape, composition, and surface, so that they can be both highly specific and highly efficient. This makes them perfect platforms for a variety of environmental applications including sensing, treatment and remediation. Providing an array of cutting-edge nanotechnology research in water applications, including sensing, treatment, and remediation, as well as a discussion of progress in the rational design and engineering of nanomaterials for environmental applications, this book is a valuable reference for researchers working in applications for nanotechnology, environmental chemistry and environmental engineering as well as those working in the water treatment industry.

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Asymmetric autocatalysis is a reaction in which chiral compound acts as a chiral catalyst for its own production. The process is a catalytic automultiplication of the chiral compound leading to an end product with a high enantiomeric excess. It has advantages over non-autocatalytic reactions because the amount of catalyst increases and no loss or deterioration of the catalyst is observed. Additionally, because the catalyst and product have the same structure, the separation of product from the catalyst is not necessary. Asymmetric Autocatalysis provides a comprehensive introduction to the topic of autocatalysis and an in-depth review of the current state of the research. Edited by a team including Professor Kenso Soai, who first described these types of reaction, and written by experts from around the world this book is a great resource for anyone with an interest in organic synthesis, catalysis and chirality.

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The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.

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Beneficial properties of graphitic carbon nitride (gCN) have been discovered in recent years during the promotion of its visible‐light‐driven photocatalytic activity for water splitting. Applications of gCN have flourished in such fields as renewable energy production and environmental remediation, while gCNs have been explored to serve as electrocatalysts, electronic and photoelectronic devices, non-volatile memory devices, anodes in lithium‐ion batteries, and platinum supports in polymer electrolyte fuel cells. This book covers recent advances in the rational design and characterization of gCN nanostructures for energy and environmental remediation, and discusses achievements in fabrication approaches of gCN nanostructures using various chemical and physical approaches. It highlights recent advances in the theoretical and experimental development of novel multidimensional nanoarchitectonics of gCNs along with insight into catalytic energy production, energy storage, and environmental remediation. Practical applications and utilization of gCN based devices are also discussed. With contributions from leading global researchers, this title will appeal to graduate students and researchers in nanoscience, chemistry, chemical engineering and materials science who are interested in developing new gCN materials or devices.

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Alzheimer’s disease is an increasingly common form of dementia and despite rising interest in discovery of novel treatments and investigation into aetiology, there are no currently approved treatments that directly tackle the causes of the condition. Due to its multifactorial pathogenesis, current treatments are directed against symptoms and even precise diagnosis remains difficult as the majority of cases are diagnosed symptomatically and usually confirmed only by autopsy. Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities provides a comprehensive overview from aetiology and neurochemistry to diagnosis, evaluation and management of Alzheimer's disease, and latest therapeutic approaches. Intended to provide an introduction to all aspects of the disease and latest developments, this book is ideal for students, postgraduates and researchers in neurochemistry, neurological drug discovery and Alzheimer’s disease.

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Functional and structural nanomaterials are emerging materials that display interesting physical and chemical properties because of their size and surface area to volume ratio. Applications for these materials include uses in removing pollutants from the environment. Looking at the current state-of-the-art as well as future trends in the use of nanomaterials for tackling environmental issues this book covers everything from the synthesis and characterisation of these materials to their use in the removal of specific contaminants. Functional Hybrid Nanomaterials for Environmental Remediation is a useful resource both for nanomaterial scientists interested in the real world application of hybrid nanomaterials and for environmental chemists and environmental engineers interested in novel materials for environmental remediation.

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The area of research on the health benefits of berries, their bioactive compounds and their related metabolites has exploded in the last 20 years resulting in new knowledge in the understanding of their metabolism, molecular mode of action as well as their clinical significance in promoting health and preventing chronic disease. Berries and Berry Bioactive Compounds in Promoting Health, reviews state-of-the-art research findings on this exponentially growing area. This comprehensive book brings together international experts in their corresponding fields with cutting-edge reviews. Exploring the effects and mechanisms of action of berry bioactive compounds and their metabolites on different body systems and chronic diseases, including their role on gut microbiota and eventual effect on health is the focus of this book. Unique topics covered, include the chemistry and analytical methods of detection of berry bioactive compounds, bioavailability, metabolism and factors that affect them including individual variability, their interaction with the gut microbiome, and their role and mechanism(s) of action on chronic diseases such as cardiovascular disease, diabetes mellitus, metabolic syndrome and obesity-induced inflammation, and cancer as well as neuroprotection and wound healing. It will be of benefit to scientists conducting research in the area of berries and their bioactive compounds on health and disease and for health care professionals, nutritionists, dietitians and clinical researchers, nutraceutical and natural food product developers (industry) and food regulators.

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Neurotransmitters and Toxicology will be particularly appealing to toxicologists interested in neurotoxicology in various sub-disciplines, as well as neuro-chemists interested in pathology and disease mechanisms associated with neurotoxicants.

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This book contains the latest information on all aspects of the most important chemical thermodynamic properties of Gibbs energy and Helmholtz energy, as related to fluids. Both the Gibbs energy and Helmholtz energy are very important in the fields of thermodynamics and material properties as many other properties are obtained from the temperature or pressure dependence. Bringing all the information into one authoritative survey, the book is written by acknowledged world experts in their respective fields. Each of the chapters will cover theory, experimental methods and techniques and results for all types of liquids and vapours. This book is the fourth in the series of Thermodynamic Properties related to liquids, solutions and vapours, edited by Emmerich Wilhelm and Trevor Letcher. The previous books were: Heat Capacities (2010), Volume Properties (2015), and Enthalpy (2017). This book fills the gap in fundamental thermodynamic properties and is the last in the series.

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Induction of DNA damage by sunlight is a major deleterious event in living organisms. Recent developments have dramatically improved our understanding of the photochemical processes involved at the sub-picosecond time scale and along with next generation sequencing and data processing has generated a need for a complete up-to-date coverage of the field. Written in an accessible and comprehensive manner, DNA Photodamage will appeal to all scientists working in the area whether specialists in the discipline or not and provides a complete coverage of the field, from ultrafast spectroscopy to biomedical research. Bridging the gap between photophysical and photochemical research on model systems, and in vivo and in vitro biological studies, this book aims to identify the most important research trends in the field and review their major findings.

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With the expansion of human settlements and the environmental changes brought on by human activity and pollutants toxicology and risk assessment of mammal species is becoming increasingly of interest to toxicologists involved in environmental research. This book focuses specifically on environmental risk assessment in marsupial and placental mammals. Marsupial ecotoxicology is poorly understood in scientific research and as such environmental risk assessment in marsupials is an area of rapidly growing interest. This book will be an ideal companion to toxicologists and ecologists interested in risk assessment in the environments of mammals. Particularly those with an interest in the impact introduced by human activity. The book will also be of interest to those working in conservation biology, biological invasion, biocontrol and habitat management.

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Porphyrinoids are pyrrole-containing macrocycles with varied core sizes, which have found many applications beyond the original chemical and biological aspects. Porphyrin research has a long history, covering a wide variety of disciplines of natural sciences, including photosynthesis, P450-related biocatalysis, organic photovoltaic cells, photodynamic therapeutic agents, bioimaging probes, chemosensors, conductive organic materials, light-emitting materials, near-infrared dyes, nonlinear optical materials, information storage, molecular wires, and metal ligands. This book gives an overview of the applications and potential applications of porphyrins and related macrocycles as smart or functional materials. Chapters cover applications in fields such as energy storage and transfer, water purification, molecular electronics and imaging. With contributions from leading global researchers, this title will be of interest to graduate students and researchers across materials science, chemistry, physics and medicine.

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The field of antioxidant research has grown rapidly over the last 30 years and shows no sign of slowing down. In order to understand how antioxidants work, it is essential to understand how their activity is measured. However, antioxidant activity measurements are controversial and their value has been challenged. This book addresses a number of the controversies on antioxidant testing methods. Specifically, the book highlights the importance of context, helping the reader to decide what methods are most appropriate for different situations, how the results can be interpreted and what information may be inferred from the data. There are a multiplicity of methods for measuring activity, with no standardized method approved for in vitro or in vivo testing. In order to select an appropriate method, a thorough knowledge of the processes associated with reduction-oxidation is essential, leading to an improved understanding and use of activity measurements and the associated data. The book presents background information, in a unique style, which is designed to assist readers to grasp the fundamentals of redox processes, as well as thermodynamics and kinetics, which are essential to later chapters. Recovery and extraction of antioxidants from diverse matrices are presented in a clear and logical fashion along with methods used to determine antioxidant activity from a mechanistic perspective. Other chapters present current methodologies used for activity testing in different sample types ranging from foods and plants, to body fluids and even to packaging, but always with a strong emphasis on the nature of the sample and the underlying chemistry of the method. A number of emerging techniques for assessing antioxidant behaviour, namely, electrochemical methods, chip technology exploiting microfluidic devices, metabolomics plus studies of gene and protein expression, are examined. Ultimately, these techniques will be involved in generation of "big data" for which an understanding of chemometrics will be essential in drawing valid conclusions. The book is written to appeal to a wide audience, but will be particularly helpful for any researchers who are attempting to make sense of the vast literature and often conflicting messages on antioxidant activity.

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Two-dimensional (2D) materials for photocatalytic applications have attracted attention in recent years due to their unique thickness-dependent physiochemical properties. 2D materials offer enhanced functionality over traditional three-dimensional (3D) photocatalysts due to modified chemical composition and electronic structures, as well as abundant surface active sites. This book reviews the applications of 2D-related nano-materials in solar-driven catalysis, providing an up-to-date introduction to the design and use of 2D-related photo(electro)catalysts. This includes not only application areas such as fine chemicals synthesis, water splitting, CO2 reduction, and N2 fixation, but also catalyst design and preparation. Some typical 2D and 2D-related materials (such as layered double hydroxides (LDHs), layered metal oxides, transition metal dichalcogenide (TMDs), metal–organic frameworks (MOFs), graphene, g-C3N4, etc.) are classified, and relationships between structure and property are demonstrated, with emphasis on how to improve 2D-related materials performance for practical applications. While the focus of this book will primarily be on experimental studies, computational results will serve as a necessary reference. With chapters written by expert researchers in their fields, Photocatalysis Using 2D Nanomaterials will provide advanced undergraduates, postgraduates and other researchers convenient introductions to these topics.

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Forensic science combines analytical science with the requirements of law enforcement agencies and legislation. This can often pose challenges within the development of novel analytical methods, particularly with the drive to have more in-field and in-situ applications to facilitate the investigation of criminal cases. This book will explore the specific challenges encountered by forensic scientists and the developments that are being made to address these within the framework of the legislative requirements. It will provide a critical appraisal of the current challenges facing analytical approaches for the detection of forensic evidence and the state of the art technologies used to address these challenges. Providing an excellent combination of current research and how this pertains to forensic investigations, the book will also highlight key obstacles within this ever-changing environment. Aimed at graduates and forensic professionals, this is a unique oversight of the current work being undertaken within the development of analytical methods and also in the interpretation of complex crime scene samples.

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Organic compounds containing amino groups are one of the most important classes of chemicals in both academia and industry. This class of materials is a very important structural motif in organic synthesis due to its widespread applications in natural products, agrochemicals, pharmaceuticals, and advanced materials. This book is a concise overview of modern approaches to N-alkylation and N-arylation of primary, secondary and tertiary amines using alkylating and arylating reagents with amino sources found in both basic and applied chemical research. The work also discusses key examples of amine synthesis from a sustainable perspective, using deep eutectic solvents and the application of amines in different areas. It is an ideal reference for advanced and postgraduate students as well as academic and industrial chemists working in organic, natural product, catalytic, medicinal, and polymer chemistry.

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With applications across chemistry, physics and medicine, nuclear magnetic resonance is a proven, uniquely versatile and powerful spectroscopic technique. The success of NMR and its constant redevelopment means that the literature is vast and wide-ranging. Each chapter in this volume is a distillation of the key recent literature in different areas, covering the spectrum of NMR theory and practice, and including theory and computation of nuclear shielding, NMR of soft matter, hyperpolarisation techniques and NMR of living systems. These reports are invaluable both for new researchers wishing to engage with literature for the first time, and for seasoned practitioners, particularly service managers, needing to keep in touch with the ever-expanding ways in which NMR is used.

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This book focuses on the application and possibility of field-effect transistors (FETS) as biosensors, for rapid and real time detection of pathogens that affect human life.

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Focusing on recent advances in the areas of feedstocks, production processes and testing and enhancement of the properties of biodiesel this book provides a balance between academic and industrial viewpoints across a range of topics.

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Sensors are significantly relevant to many aspects of life. The advancements in nanotechnology-based sensing systems are giving rise to exciting developments in sensor applications. Recently, nanocomposites have become highly promising candidates for the designing of new chemical sensing and biosensing platforms. Graphene-based nanocomposites have been successfully employed in many sensing applications in view of their excellent physical properties including high surface area, electrical conductivity, flexibility and optical transparency. They provide remarkable advantages such as lower fabrication costs, improved biocompatibility, prominent sensitivity, stability and selectivity for effective real-world implementation. The aim of the book is to give an overview on the properties and novel applications of graphene-based nanocomposites as chemical and biosensors. Chapters highlight various biosensing applications such as diabetes monitoring, cancer cell detection, virus, bacteria, DNA, protein and amino acid sensing, as well as hormone and cholesterol detection. Moreover, chemical sensing applications like gas, alcohol, and food toxin sensing, heavy metal ion detection, and H2O2 sensing are also covered. The book is ideal for postgraduates, analytical chemists, biomedical scientists and researchers in both academic and industrial settings working on materials science, chemical science and nanotechnology.

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Incidents such as nuclear weapon tests, accidents in nuclear power plants, transport accidents and accidental or authorised discharges from nuclear facilities have introduced anthropogenic radionuclides into the environment. Scientists need accurate analysis of these radionuclides in order to estimate the risk to the public from released radioactivity. This book is an authoritative, up-to-date collection from leading scientists across the globe on environmental radiochemistry and radioecology, nuclear industry decommissioning, radiation detection and imaging, medical imaging, radioanalytical techniques and nuclear forensics. The research contributions were first presented at the 14th International Symposium on Nuclear and Environmental Radiochemical Analysis in September 2022. Providing a key reference for graduates and professionals who work across fields involving analytical chemistry, radiochemistry, environmental science and technology, and waste disposal, this book is essential reading to aid risk analysis and protection.

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Carbon dots (CDs) as an emerging carbon nanomaterial have attracted considerable attention and have been widely used in numerous fields. When compared with semiconductor quantum dots and organic dyes, CDs have a low toxicity, good biocompatibility and good anti-photobleaching. These qualities give them the potential to be a greener optical probe than other types of quantum dots and organic dyes. Covering several common synthesis strategies, including biomass synthesis, large-scale synthesis and sustainable synthesis technology, this book focuses on the green synthesis of CDs and their applications in the fields of bioanalytical, catalytic, biomedical, and environmental sciences. It is a useful reference for anyone working in green chemistry, analytical chemistry, biomedical or environmental science.

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The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.

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There is an immense variety of research on polymer functionalized graphene (PFG). Functionalization of graphene is necessary for improvement of the compatibility with polymers. Applications of these graphene polymer hybrids include in chemical and biological sensing, photovoltaic devices, supercapacitors and batteries, dielectric materials and drug/gene delivery vehicles. This book will shed light on the synthesis, properties and applications of these new materials, covering two methods (covalent and noncovalent) for producing polymer functionalized graphene. Chapters cover physical, optical, mechanical and electronic properties, applications of polymer functionalized graphene in energy harvesting and storage, and uses in biomedicine and bioengineering. Written by an expert in the field, Polymer Functionalized Graphene will be of interest to graduate students and researchers in polymer chemistry and nanoscience.

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Quantum tunnelling is one of the strangest phenomena in chemistry, where we see the wave nature of atoms acting in “impossible” ways. By letting molecules pass through the kinetic barrier instead of over it, this effect can lead to chemical reactions even close to the absolute zero, to atypical spectroscopic observations, to bizarre selectivity, or to colossal isotopic effects. Quantum mechanical tunnelling observations might be infrequent in chemistry, but it permeates through all its disciplines producing remarkable chemical outcomes. For that reason, the 21st century has seen a great increase in theoretical and experimental findings involving molecular tunnelling effects, as well as in novel techniques that permit their accurate predictions and analysis. Including experimental, computational and theoretical chapters, from the physical and organic to the biochemistry fields, from the applied to the academic arenas, this new book provides a broad and conceptual perspective on tunnelling reactions and how to study them. Quantum Tunnelling in Molecules is the obligatory stop for both the specialist and those new to this world.

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Hydrogels represent one of the cornerstones in tissue engineering and regenerative medicine, due to their biocompatibility and physiologically relevant properties. These inherent characteristics mean that they can be widely exploited as bioinks in 3D bioprinting for tissue engineering applications as well as injectable gels for cell therapy and drug delivery purposes. The research in these fields is booming and this book provides the reader with a terrific introduction to the burgeoning field of injectable hydrogel design, bioprinting and tissue engineering. Edited by three leaders in the field, users of this book will learn about different classes of hydrogels, properties and synthesis strategies to produce bioinks. A section devoted to the key processing and design challenges at the hydrogel/3D bioprinting/tissue interface is also covered. The final section of the book closes with pertinent clinical applications. Tightly edited, the reader will find this book to be a coherent resource to learn from. It will appeal to those working across biomaterials science, chemical and biomedical engineering, tissue engineering and regenerative medicine.

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Focusing on the complexity of the food digestion process from oral cavity to intestine, this book looks at the anatomical intricacies of the digestive system, techniques currently used to study food digestibility, the glycemic index and bioavailability of food components. It also provides a detailed understanding of various modification techniques critical to any food product development, such as modification of food structure, its composition, and size. Being the first of its kind to provide an in-depth idea of various stages of food digestion, whilst linking it with approaches in modifying foods so as to cater to specific food or functional requirements, the book provides an integrated approach. Existing methods to understand the process of food digestion and advances in artificial systems that have been used for such studies are presented, substantiated with findings from scientific publications. Apart from readers from the field of medicine, this book is highly inter-disciplinary and will attract readers from food science, nutrition and food physics.

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Vanadium is one of the more abundant elements in the Earth’s crust and exhibits a wide range of oxidation states in its compounds making it potentially a more sustainable and more economical choice as a catalyst than the noble metals. A wide variety of reactions have been found to be catalysed by homogeneous, supported and heterogeneous vanadium complexes and the number of applications is growing fast. Bringing together the research on the catalytic uses of this element into one essential resource, including theoretical perspectives on proposed mechanisms for vanadium catalysis and an overview of its relevance in biological processes, this book is a useful reference for industrial and academic chemists alike.

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Energy storage material is a hot topic in material science and chemistry. During the past decade, nuclear magnetic resonance (NMR) has emerged as a powerful tool to aid understanding of the working and failing mechanisms of energy storage materials and devices. The aim of this book is to introduce the use of NMR methods for investigating electrochemical storage materials and devices. Presenting a comprehensive overview of NMR spectroscopy and magnetic resonance imaging (MRI) on energy storage materials, the book will include the theory of paramagnetic interactions and relevant calculation methods, a number of specific NMR approaches developed in the past decade for battery materials (e.g. in situ, ex situ NMR, MRI, DNP, 2D NMR, NMR dynamics) and case studies on a variety of related materials. Helping both NMR spectroscopists entering the field of batteries and battery specialists seeking diagnostic methods for material and device degradation, it is written by leading authorities from international research groups in this field.

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The concept of nanoarchitechtonics was introduced to describe the correct manipulation of nanoscale materials in the creation of nano-devices and applications. Nanoarchitectonics has begun to spread into many fields including nanostructured materials synthesis, supramolecular assembly, nanoscale structural fabrications, materials hybridizations, materials and structures for energy and environmental sciences, device and physical application, and bio- and medical applications. Following on from the 2012 title Manipulation of Nanoscale Materials, Concepts and Design of Materials Nanoarchitectonics covers the introductory features underlying the field, presenting a unifying overview of the theoretical aspects and emerging applications that are changing the capability to understand and design advanced functional materials. Edited by pioneers of the field, this book will appeal to researchers working in nanoscience, materials science, supramolecular chemistry, physical chemistry and organic chemistry, as well as graduate students in these areas.

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The Capsicum genus comprises the botanic species known as chili peppers, the most widely consumed natural product by humankind. Their usage is diverse and varies from food additives to defensive devices and medicines. Providing a comprehensive overview of the great popularization and socioeconomic importance of Capsicum, this book includes a holistic description of the properties of Capsicum and how this correlates with the chemical profile. Several of their specialized metabolites, such as capsaicinoids and carotenoids, are in fact responsible for peppers characterization as a functional food as they provide pungency, deterrent properties and outstanding biological activities such as antioxidant, anti-inflammatory, antimutagenic and chemopreventive. This book shows the big picture behind peppers featuring as functional foods using a biochemistry background to elucidate how the chemical composition of this genus can affect its unique bioactivity and sensorial characteristics. In addition, the state-of-art regarding Capsicum exploitation is also emphasized. Intended for all types of audiences, it is a resource for those curious about peppers pungency, for graduate students aiming to improve their skills and professional who need to update their knowledge regarding peppers chemistry and pharmacology.

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How life originated from the inanimate mixture of organic and inorganic compounds on the priomordial earth remains one of the great unknowns in science. This origin of life, or abiogenesis, continues to be examined in the context of the conditions and materials required for natural life to have begun on Earth both theoretically and experimentally. This book provides a broad but in-depth analysis of the latest discoveries in prebiotic chemsitry from the microscopic to the macroscopic scale; utilising experimental insight to provide a bottom up approach to plausibly explaining how life arose. With contributions from global leaders, this book is an ideal reference for postgraduate students and a single source of comprehensive information on the latest technical and theoretical advancements for researchers in a variety of fields from astrochemistry and astrophysics to organic chemistry and evolution.

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Practicing chemists face a number of ethical considerations, from issues of attribution of authorship through the potential environmental impact of a new process to the decision to work on chemicals that could be weaponised. By keeping ethical considerations in mind when working, chemists can build their own credibility, contribute to public trust in the chemical sciences and do science that benefits the world. Divided into three parts, methodological aspects, research ethics, and social and environmental implications, Good Chemistry introduces tools and concepts to help chemists recognise the ethical and social dimensions of their own work and act appropriately. Written to support chemistry students in their studies this book includes practice questions and examples of relevant situations to help students engage with the subject and prepare for their professional life in academia, industry, or public service.

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